Detailed information for compound 1392645

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.485 | Formula: C25H23F3N6O
  • H donors: 2 H acceptors: 3 LogP: 4.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1Cn1ccc(n1)NC(=O)c1cnn2c1NC(CC2C(F)(F)F)c1ccccc1
  • InChi: 1S/C25H23F3N6O/c1-16-7-5-6-10-18(16)15-33-12-11-22(32-33)31-24(35)19-14-29-34-21(25(26,27)28)13-20(30-23(19)34)17-8-3-2-4-9-17/h2-12,14,20-21,30H,13,15H2,1H3,(H,31,32,35)
  • InChiKey: VZZODCGNTWDMEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.0175
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.01 0.0318
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0048 0.0143
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0061 0.9595
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0063 0.0194
Loa Loa (eye worm) acetylcholinesterase 1 0.0339 0.1819 0.735
Echinococcus granulosus zinc finger protein 0.0024 0.0084 0.0262
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0852
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Echinococcus multilocularis GPCR, family 2 0.0065 0.0312 0.102
Toxoplasma gondii exonuclease III APE 0.0019 0.0061 0.0834
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Mycobacterium tuberculosis Conserved protein 0.0043 0.0193 0.0143
Brugia malayi Carboxylesterase family protein 0.0339 0.1819 0.735
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0645 0.0634
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0193 0.0143
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0048 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Echinococcus multilocularis geminin 0.0526 0.2844 0.9407
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0359
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.1086 0.4382
Mycobacterium tuberculosis Conserved hypothetical protein 0.0129 0.0661 0.065
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0058 0.0177
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0063 0.0238
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.0144
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0129 0.0661 0.0651
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0061 0.005
Trypanosoma cruzi ISWI complex protein 0.0016 0.0041 0.0482
Echinococcus multilocularis BC026374 protein (S09 family) 0.0057 0.0269 0.0877
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0167
Schistosoma mansoni hypothetical protein 0.0065 0.0312 0.1098
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0054 0.0202
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0051 0.0179
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0509 0.0485
Brugia malayi Carboxylesterase family protein 0.0057 0.0269 0.1072
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0061 0.0322
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0048 0.0175
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0057 0.0269 0.187
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0057 0.0269 0.0877
Echinococcus multilocularis nibrin 0.001 0.0011 0.0023
Loa Loa (eye worm) beta-lactamase 0.0043 0.0193 0.0763
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0025 0.007
Echinococcus multilocularis zinc finger protein 0.0024 0.0084 0.0262
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0193 0.0182
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0274 0.1092
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0312 0.1246
Schistosoma mansoni cpg binding protein 0.0064 0.0305 0.1073
Echinococcus granulosus lysine specific histone demethylase 1A 0.0129 0.0661 0.2176
Echinococcus granulosus geminin 0.0526 0.2844 0.9407
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0063 0.2751
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0101 0.0509 0.7458
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0199 0.2907
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0645 0.0632
Entamoeba histolytica hypothetical protein 0.001 0.0011 0.0437
Brugia malayi hypothetical protein 0.0129 0.0661 0.2661
Echinococcus granulosus muscleblind protein 0.0155 0.0804 0.2648
Brugia malayi topoisomerase 0.001 0.0011 0.0028
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0053 0.0199
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Brugia malayi MH1 domain containing protein 0.0009 0.0006 0.0005
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0011 0.004
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0102 0.0396
Onchocerca volvulus 0.0057 0.0269 0.1072
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.01 0.0318
Brugia malayi MH2 domain containing protein 0.025 0.133 0.5367
Brugia malayi beta-lactamase family protein 0.0043 0.0193 0.0763
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0048 0.0175
Loa Loa (eye worm) hypothetical protein 0.004 0.0172 0.0679
Onchocerca volvulus 0.0043 0.0193 0.0763
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0011 0.0023
Mycobacterium ulcerans hypothetical protein 0.0043 0.0193 0.0182
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0051 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0396
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0129 0.0661 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0034 0.0098
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0034 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Echinococcus granulosus BC026374 protein S09 family 0.0057 0.0269 0.0877
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.139 0.5611
Mycobacterium ulcerans hypothetical protein 0.0101 0.0509 0.0498
Schistosoma mansoni hypothetical protein 0.0021 0.0071 0.025
Brugia malayi Carboxylesterase family protein 0.0057 0.0269 0.1072
Trypanosoma cruzi ISWI complex protein 0.0016 0.0041 0.0482
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0061 0.0788
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0193 0.0143
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0011 0.0028
Brugia malayi Carboxylesterase family protein 0.0057 0.0269 0.1072
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0193 0.1317
Brugia malayi intermediate filament protein 0.0027 0.0102 0.0396
Mycobacterium tuberculosis Conserved protein 0.0043 0.0193 0.0143
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0051 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0099 0.0385
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1523 0.5032
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0193 0.0143
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0063 0.0374
Brugia malayi Smad1 0.0017 0.0048 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0312 0.1019
Mycobacterium tuberculosis Possible oxidoreductase 0.0129 0.0661 0.065
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0063 0.0374
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0061 0.2961
Echinococcus granulosus neuropeptide s receptor 0.0558 0.3023 1
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0063 0.0237
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0033 0.0117
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0865
Echinococcus multilocularis cpg binding protein 0.0064 0.0305 0.0997
Trichomonas vaginalis esterase, putative 0.0043 0.0193 0.1317
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0063 0.0194
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0359
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0007 0.0043
Onchocerca volvulus 0.0057 0.0269 0.1072
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0011 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0058 0.0203
Brugia malayi hypothetical protein 0.0458 0.2473 1
Echinococcus granulosus para nitrobenzyl esterase 0.0057 0.0269 0.0877
Brugia malayi N-terminal motif family protein 0.0187 0.0981 0.3954
Echinococcus granulosus intermediate filament protein 0.0027 0.0102 0.0324
Mycobacterium ulcerans dehydrogenase 0.0129 0.0661 0.0651
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0199 0.1361
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.096 0.387
Loa Loa (eye worm) runx1 0.0058 0.027 0.1075
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0158 0.051
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0199 0.2876
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0865
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0011 0.0028
Echinococcus granulosus smad 0.0017 0.0048 0.0143
Schistosoma mansoni amine oxidase 0.0129 0.0661 0.2325
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0193 0.1317
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0063 0.0194
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0896 0.3611
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Echinococcus granulosus acetylcholinesterase 0.0339 0.1819 0.6012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0193 0.0678
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0167
Entamoeba histolytica recQ family helicase, putative 0.002 0.0063 0.3067
Loa Loa (eye worm) hypothetical protein 0.0286 0.1523 0.6151
Onchocerca volvulus 0.0043 0.0193 0.0763
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0048 0.0143
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0063 0.0914
Entamoeba histolytica hypothetical protein 0.0043 0.0193 0.9676
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0048 0.0143
Echinococcus granulosus replication factor c subunit 1 0.001 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0217
Mycobacterium ulcerans carboxylesterase, LipT 0.0057 0.0269 0.0258
Echinococcus multilocularis lamin 0.0027 0.0102 0.0324
Echinococcus multilocularis carboxylesterase 5A 0.0339 0.1819 0.6012
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0645 0.2267
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0004 0.0015
Entamoeba histolytica recQ family helicase, putative 0.001 0.0007 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Schistosoma mansoni lamin 0.0027 0.0102 0.0359
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Echinococcus granulosus nibrin 0.001 0.0011 0.0023
Echinococcus granulosus Smad4 0.0017 0.0048 0.0143
Schistosoma mansoni DNA helicase recq5 0.002 0.0063 0.0221
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0011 0.0028
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0645 0.9731
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Chlamydia trachomatis protoporphyrinogen oxidase 0.0129 0.0661 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.0788
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0312 0.102
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0312 0.1019
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Schistosoma mansoni intermediate filament proteins 0.0027 0.0102 0.0359
Loa Loa (eye worm) nuclear factor I 0.0009 0.0006 0.0005
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0129 0.0661 1
Onchocerca volvulus 0.0027 0.0102 0.0396
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0004 0.0015
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.133 0.5367
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0193 0.0624
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0129 0.0661 0.2325
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0237
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0011 0.0437
Loa Loa (eye worm) carboxylesterase 0.0057 0.0269 0.1072
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.096 0.3376
Brugia malayi hypothetical protein 0.001 0.0011 0.0028
Brugia malayi CXXC zinc finger family protein 0.0059 0.0276 0.11
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Schistosoma mansoni hypothetical protein 0.0065 0.0312 0.1098
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0102 0.0396
Schistosoma mansoni DNA ligase IV 0.001 0.0011 0.004
Schistosoma mansoni cpg binding protein 0.0064 0.0305 0.1073
Mycobacterium ulcerans beta-lactamase 0.0043 0.0193 0.0182
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0214
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.139 0.5611
Trypanosoma cruzi UDP-galactopyranose mutase 0.0129 0.0661 1
Treponema pallidum DNA ligase (lig) 0.001 0.0011 0.0037
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0129 0.0661 0.2325
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0011 0.013
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Brugia malayi Bromodomain containing protein 0.004 0.0172 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Schistosoma mansoni bromodomain containing protein 0.0069 0.0332 0.1168
Brugia malayi hypothetical protein 0.0043 0.0193 0.0762
Schistosoma mansoni inositol monophosphatase 0.0045 0.0199 0.0699
Schistosoma mansoni BC026374 protein (S09 family) 0.0057 0.0269 0.0946
Brugia malayi DKFZp564C0469 protein 0.001 0.0011 0.0028
Echinococcus multilocularis acetylcholinesterase 0.0339 0.1819 0.6012
Loa Loa (eye worm) hypothetical protein 0.0458 0.2473 1
Schistosoma mansoni gliotactin 0.0057 0.0269 0.0946
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0645 0.2121
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0061 0.0818
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Echinococcus multilocularis musashi 0.0027 0.0102 0.0324
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0057 0.0269 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0129 0.0661 1
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.133 0.5367
Mycobacterium ulcerans lipase LipD 0.0043 0.0193 0.0182
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0339 0.1819 0.6397
Onchocerca volvulus 0.0027 0.0102 0.0396
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Toxoplasma gondii histone lysine-specific demethylase 0.0129 0.0661 0.971
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0048 0.0167
Brugia malayi Carboxylesterase family protein 0.0339 0.1819 0.735
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0033 0.0117
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0193 0.0143
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.3023 1
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0101 0.0509 0.0498
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.3023 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.0113
Echinococcus granulosus lamin 0.0027 0.0102 0.0324
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0053 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0645 0.0634
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.096 0.387
Onchocerca volvulus 0.0458 0.2473 1
Echinococcus granulosus GPCR family 2 0.0065 0.0312 0.102
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0057 0.0269 0.0946
Schistosoma mansoni myst-related protein 0.0009 0.0003 0.0009
Brugia malayi SWIRM domain containing protein 0.0129 0.0661 0.2661
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0011 0.0102
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0312 0.1246
Onchocerca volvulus 0.0043 0.0193 0.0763
Toxoplasma gondii ABC1 family protein 0.0043 0.0193 0.2785
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0063 0.0374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.096 0.3376
Schistosoma mansoni survival motor neuron protein 0.0058 0.0274 0.0963
Leishmania major hypothetical protein, conserved 0.0043 0.0193 0.2449
Schistosoma mansoni amine oxidase 0.0129 0.0661 0.2325
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0193 0.0611
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.1086 0.4382
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0132 0.0681 1
Onchocerca volvulus 0.0129 0.0661 0.2661
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0009 0.0075
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0015
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0057 0.0269 0.0946
Entamoeba histolytica hypothetical protein 0.0043 0.0193 0.9676
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.148 0.1538
Brugia malayi hypothetical protein 0.0286 0.1523 0.6151
Schistosoma mansoni zinc finger protein 0.0016 0.0041 0.0144
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0193 0.0624
Trichomonas vaginalis helicase, putative 0.0013 0.0027 0.0113
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0551 0.2981 0.2973
Plasmodium falciparum protoporphyrinogen oxidase 0.0129 0.0661 1
Schistosoma mansoni hypothetical protein 0.0526 0.2844 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0276 0.11
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0011 0.0028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0193 0.0624
Echinococcus granulosus acetylcholinesterase 0.0339 0.1819 0.6012
Schistosoma mansoni acetylcholinesterase 0.0057 0.0269 0.0946
Loa Loa (eye worm) hypothetical protein 0.0141 0.0728 0.2931
Loa Loa (eye worm) hypothetical protein 0.0206 0.1086 0.4382
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0193 0.1317
Onchocerca volvulus 0.0057 0.0269 0.1072
Treponema pallidum licC protein (licC) 0.0101 0.0509 1
Brugia malayi beta-lactamase family protein 0.0043 0.0193 0.0763
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.002
Schistosoma mansoni smad 0.0017 0.0048 0.0167
Brugia malayi Carboxylesterase family protein 0.0057 0.0269 0.1072
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0804 0.2648
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0173 0.0545
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0061 0.0229
Mycobacterium tuberculosis Carboxylesterase LipT 0.0057 0.0269 0.0226
Echinococcus granulosus lysine specific histone demethylase 1A 0.0129 0.0661 0.2176
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0071 0.0271
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.2639
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0199 0.2907
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Brugia malayi PHD-finger family protein 0.0029 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.0175
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0728 0.2931
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0061 0.0882
Onchocerca volvulus 0.001 0.0011 0.0028
Onchocerca volvulus 0.0059 0.0276 0.11
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.1086 0.4382
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.01 0.0353
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0947 0.6786
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0193 0.0143
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0058 0.0177
Mycobacterium tuberculosis Conserved protein 0.0043 0.0193 0.0143
Brugia malayi Bromodomain containing protein 0.0081 0.0399 0.1598
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0199 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Loa Loa (eye worm) hypothetical protein 0.0458 0.2473 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0057 0.0269 0.0877
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0063 0.0194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.096 0.3166
Schistosoma mansoni Smad4 0.0017 0.0048 0.0167
Loa Loa (eye worm) hypothetical protein 0.0155 0.0804 0.3237
Mycobacterium ulcerans oxidoreductase 0.0129 0.0661 0.0651
Schistosoma mansoni zinc finger protein 0.0024 0.0084 0.0294
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0011 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.002
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.3023 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0061 0.0187
Schistosoma mansoni hypothetical protein 0.0043 0.0193 0.0677
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0009 0.0032
Trypanosoma brucei ISWI complex protein 0.0016 0.0041 0.1576
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0312 0.102
Loa Loa (eye worm) hypothetical protein 0.0339 0.1819 0.735
Loa Loa (eye worm) RecQ helicase 0.002 0.0063 0.0237
Echinococcus multilocularis 0.0129 0.0661 0.2176
Echinococcus granulosus bloom syndrome protein 0.002 0.0063 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0057 0.0269 0.0877
Schistosoma mansoni hypothetical protein 0.0065 0.0312 0.1098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.096 0.3166
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0578 0.8474
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0199 0.0632
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0551 0.2981 1
Schistosoma mansoni hypothetical protein 0.0058 0.0274 0.0963
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0173 0.0122
Brugia malayi amine oxidase, flavin-containing family protein 0.0129 0.0661 0.2661
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0063 0.082
Brugia malayi Inositol-1 0.0045 0.0199 0.0788
Echinococcus granulosus carboxylesterase 5A 0.0339 0.1819 0.6012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0356 0.1425
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.096 0.3376
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0053 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.096 0.3166
Brugia malayi beta-lactamase 0.0043 0.0193 0.0763
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0237
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0058 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0193 0.2813
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0057 0.0269 0.0946
Schistosoma mansoni lozenge 0.0058 0.027 0.0949
Echinococcus multilocularis bloom syndrome protein 0.002 0.0063 0.0194
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0551 0.2981 0.3164
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0057 0.0269 0.0226
Schistosoma mansoni dep domain containing protein 0.0009 0.0004 0.0015
Schistosoma mansoni inositol monophosphatase 0.0045 0.0199 0.0699
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0551 0.2981 1
Mycobacterium ulcerans hypothetical protein 0.0101 0.0509 0.0498
Echinococcus multilocularis smad 0.0017 0.0048 0.0143
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0129 0.0661 1
Echinococcus granulosus lamin dm0 0.0027 0.0102 0.0324
Schistosoma mansoni lamin 0.0027 0.0102 0.0359
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0063 0.0237
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0193 0.0677
Loa Loa (eye worm) hypothetical protein 0.0065 0.0312 0.1246
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0061 0.1029
Echinococcus granulosus cpg binding protein 0.0064 0.0305 0.0997
Echinococcus multilocularis Protein lozenge 0.0058 0.027 0.088
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0063 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0129 0.0661 0.2176
Brugia malayi MH1 domain containing protein 0.0009 0.0006 0.0005
Loa Loa (eye worm) inositol-1 0.0045 0.0199 0.0788
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0199 0.1361
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0193 0.0624
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0061 0.0167
Plasmodium vivax hypothetical protein, conserved 0.0129 0.0661 1
Loa Loa (eye worm) carboxylesterase 0.0057 0.0269 0.1072
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0193 0.9671
Loa Loa (eye worm) Smad1 0.0017 0.0048 0.0175
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0637 0.2241
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0645 0.0634
Entamoeba histolytica hypothetical protein 0.0043 0.0193 0.9676
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0034 0.0098
Echinococcus granulosus neuroligin 0.0057 0.0269 0.0877
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0199 0.0645
Schistosoma mansoni hypothetical protein 0.0526 0.2844 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1523 0.5032
Brugia malayi hypothetical protein 0.001 0.0011 0.0028
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.0981 0.3954
Leishmania major UDP-galactopyranose mutase 0.0129 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Schistosoma mansoni topbp1 0.001 0.0011 0.004
Schistosoma mansoni topbp1 0.001 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0155 0.0804 0.3237
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0199 0.0645
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0193 0.2836
Echinococcus multilocularis protoporphyrinogen oxidase 0.0129 0.0661 0.2176
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0061 0.0187
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0199 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0061 0.0229
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0025 0.007
Mycobacterium ulcerans monoamine oxidase 0.0129 0.0661 0.0651
Entamoeba histolytica hypothetical protein 0.0043 0.0193 0.9676
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0645 0.2267
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.0175
Loa Loa (eye worm) hypothetical protein 0.0339 0.1819 0.735
Onchocerca volvulus 0.0057 0.0269 0.1072
Echinococcus multilocularis lamin dm0 0.0027 0.0102 0.0324
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0193 0.0763
Entamoeba histolytica recQ family DNA helicase 0.001 0.0009 0.0342
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0214
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0199 0.0188
Mycobacterium leprae Probable lipase LipE 0.0043 0.0193 0.0611
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0158 0.051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0193 0.0143
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0063 0.0355
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0193 0.1317
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0057 0.0269 0.187
Loa Loa (eye worm) hypothetical protein 0.0187 0.0981 0.3954
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Onchocerca volvulus 0.0057 0.0269 0.1072
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Echinococcus multilocularis muscleblind protein 0.0155 0.0804 0.2648
Trypanosoma cruzi UDP-galactopyranose mutase 0.0129 0.0661 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0057 0.0269 0.0946
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0193 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0947 0.6786
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Plasmodium vivax hypothetical protein, conserved 0.0129 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0312 0.102
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0312 0.102
Echinococcus multilocularis acetylcholinesterase 0.0339 0.1819 0.6012
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0645 0.9463
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0034 0.0119
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0007 0.0026
Loa Loa (eye worm) carboxylesterase 0.0339 0.1819 0.735
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0102 0.0396
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0237
Echinococcus multilocularis neuroligin 0.0057 0.0269 0.0877
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.096 0.3166
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Schistosoma mansoni hypothetical protein 0.0141 0.0728 0.256
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0199 0.2548
Echinococcus multilocularis Smad4 0.0017 0.0048 0.0143
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0129 0.0661 0.2189
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1828 1 1
Brugia malayi Muscleblind-like protein 0.0155 0.0804 0.3237
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0199 0.1361
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0063 0.0914
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0167
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1699 0.9293 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0186 0.0734
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0193 0.1317
Brugia malayi hypothetical protein 0.0057 0.0269 0.1072
Onchocerca volvulus 0.0058 0.0274 0.1092
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0009 0.0033
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.0113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0193 0.0678
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.0175
Schistosoma mansoni myst-related protein 0.0009 0.0003 0.0009
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0034 0.0098
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0645 0.2121
Schistosoma mansoni hypothetical protein 0.0065 0.0312 0.1098
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0011 0.0102
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0051 0.0179
Schistosoma mansoni cpg binding protein 0.0059 0.0276 0.0971
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0312 0.1246
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0193 0.0763
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0193 0.0143
Schistosoma mansoni DNA helicase recq1 0.002 0.0063 0.0221
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0193 0.2813
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0509 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0011 0.0028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0045 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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