Detailed information for compound 1392645

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.485 | Formula: C25H23F3N6O
  • H donors: 2 H acceptors: 3 LogP: 4.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1Cn1ccc(n1)NC(=O)c1cnn2c1NC(CC2C(F)(F)F)c1ccccc1
  • InChi: 1S/C25H23F3N6O/c1-16-7-5-6-10-18(16)15-33-12-11-22(32-33)31-24(35)19-14-29-34-21(25(26,27)28)13-20(30-23(19)34)17-8-3-2-4-9-17/h2-12,14,20-21,30H,13,15H2,1H3,(H,31,32,35)
  • InChiKey: VZZODCGNTWDMEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi topoisomerase 0.001 0.0011 0.0028
Onchocerca volvulus 0.0027 0.0102 0.0396
Echinococcus multilocularis protoporphyrinogen oxidase 0.0129 0.0661 0.2176
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0551 0.2981 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Mycobacterium ulcerans oxidoreductase 0.0129 0.0661 0.0651
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0158 0.051
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0015
Echinococcus granulosus bloom syndrome protein 0.002 0.0063 0.0194
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0173 0.0122
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0085
Trypanosoma cruzi ISWI complex protein 0.0016 0.0041 0.0482
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0011 0.0102
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0061 0.0229
Echinococcus multilocularis 0.0129 0.0661 0.2176
Mycobacterium tuberculosis Conserved protein 0.0043 0.0193 0.0143
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0061 0.0322
Schistosoma mansoni myst-related protein 0.0009 0.0003 0.0009
Echinococcus granulosus acetylcholinesterase 0.0339 0.1819 0.6012
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0193 0.0611
Echinococcus multilocularis musashi 0.0027 0.0102 0.0324
Echinococcus granulosus carboxylesterase 5A 0.0339 0.1819 0.6012
Schistosoma mansoni bromodomain containing protein 0.0069 0.0332 0.1168
Brugia malayi PHD-finger family protein 0.0029 0.0114 0.0444
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0339 0.1819 0.6397
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.096 0.387
Mycobacterium ulcerans lipase LipD 0.0043 0.0193 0.0182
Schistosoma mansoni dep domain containing protein 0.0009 0.0004 0.0015
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0199 1
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.3023 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0061 0.0818
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0057 0.0269 0.187
Echinococcus granulosus replication factor c subunit 1 0.001 0.0011 0.0023
Echinococcus granulosus smad 0.0017 0.0048 0.0143
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0551 0.2981 0.2973
Echinococcus multilocularis BC026374 protein (S09 family) 0.0057 0.0269 0.0877
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0193 0.1317
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0237
Loa Loa (eye worm) hypothetical protein 0.0339 0.1819 0.735
Echinococcus multilocularis lamin dm0 0.0027 0.0102 0.0324
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0214
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0193 0.1317
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0048 0.0143
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0048 0.0175
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.096 0.3166
Echinococcus multilocularis cpg binding protein 0.0064 0.0305 0.0997
Toxoplasma gondii ABC1 family protein 0.0043 0.0193 0.2785
Loa Loa (eye worm) hypothetical protein 0.004 0.0172 0.0679
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0193 0.0763
Schistosoma mansoni hypothetical protein 0.0043 0.0193 0.0677
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0063 0.0914
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.096 0.387
Echinococcus multilocularis geminin 0.0526 0.2844 0.9407
Brugia malayi beta-lactamase 0.0043 0.0193 0.0763
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.148 0.1538
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0063 0.0374
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0193 0.0624
Brugia malayi N-terminal motif family protein 0.0187 0.0981 0.3954
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0063 0.2751
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0011 0.0028
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0048 0.0143
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0063 0.0237
Brugia malayi intermediate filament protein 0.0027 0.0102 0.0396
Mycobacterium ulcerans dehydrogenase 0.0129 0.0661 0.0651
Loa Loa (eye worm) hypothetical protein 0.0155 0.0804 0.3237
Brugia malayi Carboxylesterase family protein 0.0057 0.0269 0.1072
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1828 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0193 0.9671
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Schistosoma mansoni hypothetical protein 0.0058 0.0274 0.0963
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0193 0.0143
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0129 0.0661 0.2325
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0193 0.1317
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Schistosoma mansoni zinc finger protein 0.0016 0.0041 0.0144
Onchocerca volvulus 0.0057 0.0269 0.1072
Schistosoma mansoni gliotactin 0.0057 0.0269 0.0946
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0054 0.0202
Loa Loa (eye worm) beta-lactamase 0.0043 0.0193 0.0763
Brugia malayi beta-lactamase family protein 0.0043 0.0193 0.0763
Entamoeba histolytica recQ family DNA helicase 0.001 0.0009 0.0342
Onchocerca volvulus 0.0043 0.0193 0.0763
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0645 0.0634
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0058 0.0177
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0199 0.1361
Loa Loa (eye worm) runx1 0.0058 0.027 0.1075
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0199 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0865
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0217
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0359
Schistosoma mansoni topbp1 0.001 0.0011 0.004
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0199 0.0188
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0199 0.0645
Trichomonas vaginalis helicase, putative 0.0013 0.0027 0.0113
Echinococcus multilocularis neuroligin 0.0057 0.0269 0.0877
Schistosoma mansoni hypothetical protein 0.0021 0.0071 0.025
Loa Loa (eye worm) hypothetical protein 0.0286 0.1523 0.6151
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0193 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Loa Loa (eye worm) hypothetical protein 0.0458 0.2473 1
Entamoeba histolytica hypothetical protein 0.0043 0.0193 0.9676
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0312 0.1246
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0509 0.0485
Onchocerca volvulus 0.0027 0.0102 0.0396
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0057 0.0269 0.0226
Echinococcus granulosus lysine specific histone demethylase 1A 0.0129 0.0661 0.2176
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0061 0.0187
Echinococcus granulosus muscleblind protein 0.0155 0.0804 0.2648
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0804 0.2648
Echinococcus multilocularis para nitrobenzyl esterase 0.0057 0.0269 0.0877
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0063 0.0194
Leishmania major hypothetical protein, conserved 0.0043 0.0193 0.2449
Onchocerca volvulus 0.0057 0.0269 0.1072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0193 0.0678
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Echinococcus granulosus intermediate filament protein 0.0027 0.0102 0.0324
Mycobacterium tuberculosis Conserved protein 0.0043 0.0193 0.0143
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0193 0.0677
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0101 0.0509 0.7458
Schistosoma mansoni cpg binding protein 0.0064 0.0305 0.1073
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0645 0.9463
Schistosoma mansoni lamin 0.0027 0.0102 0.0359
Loa Loa (eye worm) hypothetical protein 0.0027 0.0099 0.0385
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0048 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Brugia malayi hypothetical protein 0.001 0.0011 0.0028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0007 0.0043
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.0175
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0048 0.0167
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0193 0.0143
Echinococcus granulosus nibrin 0.001 0.0011 0.0023
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0129 0.0661 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0199 0.0632
Onchocerca volvulus 0.0057 0.0269 0.1072
Echinococcus granulosus neuroligin 0.0057 0.0269 0.0877
Loa Loa (eye worm) hypothetical protein 0.0073 0.0356 0.1425
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0173 0.0545
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0051 0.0154
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0053 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Chlamydia trachomatis protoporphyrinogen oxidase 0.0129 0.0661 1
Trypanosoma brucei ISWI complex protein 0.0016 0.0041 0.1576
Brugia malayi amine oxidase, flavin-containing family protein 0.0129 0.0661 0.2661
Echinococcus multilocularis GPCR, family 2 0.0065 0.0312 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.1086 0.4382
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0057 0.0269 0.0877
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0193 0.0143
Loa Loa (eye worm) carboxylesterase 0.0057 0.0269 0.1072
Loa Loa (eye worm) carboxylesterase 0.0339 0.1819 0.735
Echinococcus granulosus zinc finger protein 0.0024 0.0084 0.0262
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0063 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0058 0.0177
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0009 0.0033
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.0981 0.3954
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0645 0.2121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0312 0.1246
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0057 0.0269 0.0946
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0015
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0214
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.2639
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0061 0.0882
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0551 0.2981 0.3164
Mycobacterium ulcerans hypothetical protein 0.0043 0.0193 0.0182
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.0144
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0033 0.0117
Brugia malayi MH1 domain containing protein 0.0009 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0865
Schistosoma mansoni hypothetical protein 0.0065 0.0312 0.1098
Brugia malayi hypothetical protein 0.0286 0.1523 0.6151
Schistosoma mansoni smad 0.0017 0.0048 0.0167
Schistosoma mansoni intermediate filament proteins 0.0027 0.0102 0.0359
Echinococcus multilocularis nibrin 0.001 0.0011 0.0023
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0129 0.0661 0.2189
Loa Loa (eye worm) Smad1 0.0017 0.0048 0.0175
Onchocerca volvulus 0.0057 0.0269 0.1072
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0011 0.0028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0034 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0312 0.102
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0199 0.2907
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0237
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0129 0.0661 1
Toxoplasma gondii histone lysine-specific demethylase 0.0129 0.0661 0.971
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1523 0.5032
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0193 0.1317
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0193 0.0143
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0058 0.0203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.0788
Treponema pallidum DNA ligase (lig) 0.001 0.0011 0.0037
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0011 0.004
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0728 0.2931
Plasmodium vivax hypothetical protein, conserved 0.0129 0.0661 1
Brugia malayi Carboxylesterase family protein 0.0339 0.1819 0.735
Loa Loa (eye worm) hypothetical protein 0.0065 0.0312 0.1246
Trypanosoma cruzi UDP-galactopyranose mutase 0.0129 0.0661 1
Echinococcus granulosus BC026374 protein S09 family 0.0057 0.0269 0.0877
Loa Loa (eye worm) nuclear factor I 0.0009 0.0006 0.0005
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0057 0.0269 0.0946
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0947 0.6786
Schistosoma mansoni hypothetical protein 0.0065 0.0312 0.1098
Mycobacterium ulcerans beta-lactamase 0.0043 0.0193 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Schistosoma mansoni inositol monophosphatase 0.0045 0.0199 0.0699
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0312 0.102
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0551 0.2981 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0509 0.0485
Schistosoma mansoni hypothetical protein 0.0526 0.2844 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0057 0.0269 0.0946
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0011 0.0061
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0199 0.1361
Echinococcus granulosus lamin dm0 0.0027 0.0102 0.0324
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0074
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1699 0.9293 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0193 0.0624
Onchocerca volvulus 0.001 0.0011 0.0028
Schistosoma mansoni acetylcholinesterase 0.0057 0.0269 0.0946
Schistosoma mansoni hypothetical protein 0.0526 0.2844 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.139 0.5611
Leishmania major UDP-galactopyranose mutase 0.0129 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0645 0.2267
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0193 0.0182
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.133 0.5367
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Mycobacterium ulcerans hypothetical protein 0.0101 0.0509 0.0498
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1523 0.5032
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.096 0.3166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0193 0.0678
Schistosoma mansoni cpg binding protein 0.0064 0.0305 0.1073
Trypanosoma cruzi ISWI complex protein 0.0016 0.0041 0.0482
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0947 0.6786
Brugia malayi CXXC zinc finger family protein 0.0059 0.0276 0.11
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0034 0.0098
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0061 0.0187
Schistosoma mansoni hypothetical protein 0.0065 0.0312 0.1098
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0009 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Onchocerca volvulus 0.0043 0.0193 0.0763
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Brugia malayi Bromodomain containing protein 0.0081 0.0399 0.1598
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0274 0.0963
Echinococcus multilocularis Smad4 0.0017 0.0048 0.0143
Brugia malayi beta-lactamase family protein 0.0043 0.0193 0.0763
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.096 0.3166
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0063 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0051 0.0179
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0061 0.2961
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0061 0.0788
Echinococcus granulosus Smad4 0.0017 0.0048 0.0143
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0033 0.0117
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0129 0.0661 0.2325
Mycobacterium ulcerans hypothetical protein 0.0101 0.0509 0.0498
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0158 0.051
Entamoeba histolytica recQ family helicase, putative 0.001 0.0007 0.0234
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0199 0.2548
Loa Loa (eye worm) hypothetical protein 0.0458 0.2473 1
Brugia malayi hypothetical protein 0.0458 0.2473 1
Brugia malayi hypothetical protein 0.0057 0.0269 0.1072
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0063 0.0374
Mycobacterium leprae Probable lipase LipE 0.0043 0.0193 0.0611
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0129 0.0661 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.1086 0.4382
Echinococcus multilocularis bloom syndrome protein 0.002 0.0063 0.0194
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0011 0.013
Schistosoma mansoni myst-related protein 0.0009 0.0003 0.0009
Schistosoma mansoni Smad4 0.0017 0.0048 0.0167
Loa Loa (eye worm) hypothetical protein 0.0042 0.0186 0.0734
Echinococcus multilocularis zinc finger protein 0.0024 0.0084 0.0262
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0011 0.0028
Loa Loa (eye worm) hypothetical protein 0.0155 0.0804 0.3237
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0193 0.0182
Schistosoma mansoni hypothetical protein 0.0065 0.0312 0.1098
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0071 0.0271
Brugia malayi hypothetical protein 0.0043 0.0193 0.0762
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0011 0.0023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0578 0.8474
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0048 0.0175
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0645 0.9731
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0011 0.0028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0312 0.102
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0025 0.007
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0057 0.0269 0.0877
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.096 0.3166
Entamoeba histolytica recQ family helicase, putative 0.002 0.0063 0.3067
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0312 0.1019
Brugia malayi Carboxylesterase family protein 0.0057 0.0269 0.1072
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0129 0.0661 0.0651
Schistosoma mansoni topbp1 0.001 0.0011 0.004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0645 0.0634
Loa Loa (eye worm) hypothetical protein 0.0187 0.0981 0.3954
Schistosoma mansoni BC026374 protein (S09 family) 0.0057 0.0269 0.0946
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0009 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0011 0.0028
Echinococcus granulosus para nitrobenzyl esterase 0.0057 0.0269 0.0877
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0237
Schistosoma mansoni cpg binding protein 0.0059 0.0276 0.0971
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0193 0.0143
Echinococcus multilocularis carboxylesterase 5A 0.0339 0.1819 0.6012
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.3023 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0061 0.9595
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0063 0.0237
Entamoeba histolytica hypothetical protein 0.0043 0.0193 0.9676
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0312 0.1019
Echinococcus multilocularis smad 0.0017 0.0048 0.0143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0061 0.0167
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.0175
Echinococcus granulosus lamin 0.0027 0.0102 0.0324
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0063 0.082
Brugia malayi hypothetical protein 0.0129 0.0661 0.2661
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0004 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.139 0.5611
Schistosoma mansoni amine oxidase 0.0129 0.0661 0.2325
Brugia malayi Smad1 0.0017 0.0048 0.0175
Echinococcus granulosus acetylcholinesterase 0.0339 0.1819 0.6012
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0063 0.0914
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0034 0.0098
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0199 0.2907
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.1086 0.4382
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0645 0.2121
Onchocerca volvulus 0.0058 0.0274 0.1092
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0048 0.0143
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0063 0.0194
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Entamoeba histolytica hypothetical protein 0.001 0.0011 0.0437
Onchocerca volvulus 0.0057 0.0269 0.1072
Onchocerca volvulus 0.0458 0.2473 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0057 0.0269 0.0946
Treponema pallidum licC protein (licC) 0.0101 0.0509 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0359
Trichomonas vaginalis spcc417.12 protein, putative 0.0057 0.0269 0.187
Echinococcus multilocularis muscleblind protein 0.0155 0.0804 0.2648
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0004 0.0015
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0276 0.11
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0645 0.0634
Echinococcus granulosus geminin 0.0526 0.2844 0.9407
Mycobacterium tuberculosis Possible oxidoreductase 0.0129 0.0661 0.065
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.0175
Echinococcus multilocularis acetylcholinesterase 0.0339 0.1819 0.6012
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0102 0.0396
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0053 0.0199
Mycobacterium ulcerans carboxylesterase, LipT 0.0057 0.0269 0.0258
Brugia malayi Carboxylesterase family protein 0.0057 0.0269 0.1072
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0004 0.0015
Schistosoma mansoni DNA helicase recq1 0.002 0.0063 0.0221
Schistosoma mansoni DNA ligase IV 0.001 0.0011 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.096 0.3376
Brugia malayi Muscleblind-like protein 0.0155 0.0804 0.3237
Onchocerca volvulus 0.0059 0.0276 0.11
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0199 0.0645
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0025 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0102 0.0396
Schistosoma mansoni zinc finger protein 0.0024 0.0084 0.0294
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0645 0.0632
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0896 0.3611
Brugia malayi MH1 domain containing protein 0.0009 0.0006 0.0005
Echinococcus multilocularis acetylcholinesterase 0.0339 0.1819 0.6012
Schistosoma mansoni lozenge 0.0058 0.027 0.0949
Mycobacterium tuberculosis Conserved hypothetical protein 0.0129 0.0661 0.065
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0051 0.0154
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0852
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0063 0.0194
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0101 0.0509 0.0498
Loa Loa (eye worm) carboxylesterase 0.0057 0.0269 0.1072
Mycobacterium ulcerans monoamine oxidase 0.0129 0.0661 0.0651
Loa Loa (eye worm) hypothetical protein 0.0206 0.1086 0.4382
Plasmodium falciparum protoporphyrinogen oxidase 0.0129 0.0661 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0193 0.0624
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0193 0.2813
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0063 0.0238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.096 0.3376
Plasmodium vivax hypothetical protein, conserved 0.0129 0.0661 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0193 0.2813
Echinococcus granulosus cpg binding protein 0.0064 0.0305 0.0997
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0051 0.0179
Echinococcus granulosus lysine specific histone demethylase 1A 0.0129 0.0661 0.2176
Entamoeba histolytica hypothetical protein 0.0043 0.0193 0.9676
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.096 0.3376
Brugia malayi DKFZp564C0469 protein 0.001 0.0011 0.0028
Schistosoma mansoni amine oxidase 0.0129 0.0661 0.2325
Loa Loa (eye worm) hypothetical protein 0.0339 0.1819 0.735
Echinococcus granulosus GPCR family 2 0.0065 0.0312 0.102
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0167
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.133 0.5367
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.01 0.0318
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0312 0.102
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0193 0.0143
Brugia malayi SWIRM domain containing protein 0.0129 0.0661 0.2661
Onchocerca volvulus 0.0129 0.0661 0.2661
Echinococcus multilocularis lamin 0.0027 0.0102 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.002
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0129 0.0661 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Mycobacterium tuberculosis Carboxylesterase LipT 0.0057 0.0269 0.0226
Loa Loa (eye worm) hypothetical protein 0.0141 0.0728 0.2931
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0061 0.0229
Trypanosoma cruzi UDP-galactopyranose mutase 0.0129 0.0661 1
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Entamoeba histolytica hypothetical protein 0.0043 0.0193 0.9676
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0193 0.0763
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0199 0.2876
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0129 0.0661 0.2176
Trichomonas vaginalis esterase, putative 0.0043 0.0193 0.1317
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.01 0.0318
Brugia malayi Bromodomain containing protein 0.004 0.0172 0.0678
Schistosoma mansoni hypothetical protein 0.0141 0.0728 0.256
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0312 0.1246
Toxoplasma gondii exonuclease III APE 0.0019 0.0061 0.0834
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0063 0.0194
Brugia malayi hypothetical protein 0.001 0.0011 0.0028
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0167
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0011 0.0028
Echinococcus granulosus neuropeptide s receptor 0.0558 0.3023 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0193 0.1317
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0011 0.0437
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0058 0.0203
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0274 0.1092
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0193 0.2836
Loa Loa (eye worm) RecQ helicase 0.002 0.0063 0.0237
Mycobacterium tuberculosis Conserved protein 0.0043 0.0193 0.0143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0637 0.2241
Onchocerca volvulus 0.0043 0.0193 0.0763
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0396
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0061 0.005
Schistosoma mansoni lamin 0.0027 0.0102 0.0359
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0028
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0132 0.0681 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0053 0.0163
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0061 0.1029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0034 0.0098
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0645 0.2267
Loa Loa (eye worm) inositol-1 0.0045 0.0199 0.0788
Schistosoma mansoni DNA helicase recq5 0.002 0.0063 0.0221
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0199 0.1361
Brugia malayi Carboxylesterase family protein 0.0057 0.0269 0.1072
Brugia malayi Inositol-1 0.0045 0.0199 0.0788
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0896 0.6418
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0034 0.0098
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0193 0.0624
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0763
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0011 0.0102
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.3023 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.0113
Schistosoma mansoni inositol monophosphatase 0.0045 0.0199 0.0699
Echinococcus multilocularis Protein lozenge 0.0058 0.027 0.088
Brugia malayi MH2 domain containing protein 0.025 0.133 0.5367
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0102 0.0396
Loa Loa (eye worm) hypothetical protein 0.0057 0.0269 0.1072
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.01 0.0353
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0063 0.0374
Loa Loa (eye worm) acetylcholinesterase 1 0.0339 0.1819 0.735
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.139 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Loa Loa (eye worm) hypothetical protein 0.0129 0.0661 0.2661
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0113
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0057 0.0269 0.0226
Brugia malayi Carboxylesterase family protein 0.0339 0.1819 0.735
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0113

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0045 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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