Detailed information for compound 1400619

Basic information

Technical information
  • TDR Targets ID: 1400619
  • Name: 1-[2-[[2-(hydroxymethyl)-6-phenyl-3,6-dihydro -2H-pyran-3-yl]oxy]-5-methoxyphenyl]ethanone
  • MW: 354.396 | Formula: C21H22O5
  • H donors: 1 H acceptors: 2 LogP: 2.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C=CC1Oc1ccc(cc1C(=O)C)OC)c1ccccc1
  • InChi: 1S/C21H22O5/c1-14(23)17-12-16(24-2)8-9-19(17)26-20-11-10-18(25-21(20)13-22)15-6-4-3-5-7-15/h3-12,18,20-22H,13H2,1-2H3
  • InChiKey: VZCQXKQDISUSLN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-[[2-(hydroxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl]oxy]-5-methoxy-phenyl]ethanone
  • 1-[5-methoxy-2-[(2-methylol-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy]phenyl]ethanone
  • NCGC00090436-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0065 0.0083 0.0137
Schistosoma mansoni vav2 0.0065 0.0083 0.0083
Schistosoma mansoni protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0065 0.0083 0.0083
Echinococcus granulosus ephrin type A receptor 4 A 0.0056 0.0063 0.0075
Schistosoma mansoni hypothetical protein 0.0162 0.0306 0.0306
Toxoplasma gondii protein kinase domain-containing protein 0.0083 0.0124 1
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0065 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0306 0.1845
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0063 0.0275
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0061 0.0074 0.0089
Loa Loa (eye worm) hypothetical protein 0.0114 0.0197 0.0197
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0065 0.0083 0.0137
Entamoeba histolytica PH domain containing protein kinase, putative 0.0083 0.0124 0.0406
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0114 0.0197 0.0197
Entamoeba histolytica protein kinase, putative 0.0083 0.0124 0.0406
Entamoeba histolytica protein kinase, putative 0.0077 0.011 0.031
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0065 0.0083 0.01
Entamoeba histolytica PH domain containing protein 0.0065 0.0083 0.0137
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Trypanosoma brucei rac serine-threonine kinase, putative 0.0083 0.0124 1
Toxoplasma gondii hypothetical protein 0.0065 0.0083 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0065 0.0083 0.01
Onchocerca volvulus 0.0065 0.0083 0.0432
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0065 0.0083 0.0408
Leishmania major hypothetical protein, conserved 0.0065 0.0083 0.3378
Echinococcus granulosus twitchin 0.0132 0.0237 0.0283
Trichomonas vaginalis kinesin light chain, putative 0.0065 0.0083 0.0408
Trichomonas vaginalis protein tyrosine kinase, putative 0.0056 0.0063 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0711 0.1566 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) TK/EPH protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) cytohesin 3 0.0065 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) TK/ACK protein kinase 0.0056 0.0063 0.0063
Brugia malayi Cytochrome P450 family protein 0.0032 0.0006 0.0006
Echinococcus multilocularis DCC interacting protein 13 beta 0.0065 0.0083 0.01
Loa Loa (eye worm) serine/threonine protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0162 0.0306 0.1615
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0056 0.0063 0.0075
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Brugia malayi Regulator of G protein signaling domain containing protein 0.0711 0.1566 0.1566
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0056 0.0063 0.0075
Schistosoma mansoni protein kinase 0.0056 0.0063 0.0063
Trypanosoma cruzi NIMA-related kinase, putative 0.0083 0.0124 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0077 0.011 0.7655
Echinococcus multilocularis transcription factor collier 0.0162 0.0306 0.0365
Trypanosoma cruzi PH domain containing protein, putative 0.0065 0.0083 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2648 0.6018 0.7191
Echinococcus granulosus semaphorin 5B 0.0369 0.0782 0.0935
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0083 0.0124 0.0669
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0065 0.0083 0.01
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0063 0.0075
Echinococcus granulosus tyrosine protein kinase Src64B 0.0056 0.0063 0.0075
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0065 0.0083 0.3378
Trichomonas vaginalis conserved hypothetical protein 0.0711 0.1566 1
Echinococcus multilocularis FL cytokine receptor 0.0056 0.0063 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0065 0.0083 0.01
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0065 0.0083 0.01
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0056 0.0063 0.0063
Loa Loa (eye worm) oxysterol binding protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0063 0.0275
Brugia malayi Variant SH3 domain containing protein 0.0065 0.0083 0.0083
Echinococcus granulosus protein kinase 0.0056 0.0063 0.0075
Loa Loa (eye worm) hypothetical protein 0.0114 0.0197 0.0197
Onchocerca volvulus 0.0056 0.0063 0.0325
Brugia malayi Pleckstrin Homology Domain 0.0065 0.0083 0.0083
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0711 0.1566 0.1566
Echinococcus granulosus tyrosine kinase 0.0056 0.0063 0.0075
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0056 0.0063 0.0075
Schistosoma mansoni rho gtpase activating protein 0.0065 0.0083 0.0083
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0065 0.0083 0.3378
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0063 0.0275
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Loa Loa (eye worm) AUR protein kinase 0.0077 0.011 0.011
Echinococcus multilocularis aurora kinase A 0.0077 0.011 0.0131
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0056 0.0063 0.0075
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0065 0.0083 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0077 0.011 0.0577
Schistosoma mansoni hypothetical protein 0.0065 0.0083 0.0083
Echinococcus granulosus serine/threonine protein kinase 0.0083 0.0124 0.0148
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0063 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0063 0.0275
Echinococcus multilocularis transfer RNA-Thr 0.0056 0.0063 0.0075
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0065 0.0083 0.0408
Echinococcus granulosus activated cdc42 kinase 1 0.0056 0.0063 0.0075
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.0063 0.0075
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Onchocerca volvulus 0.0056 0.0063 0.0325
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0056 0.0063 0.0075
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0056 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0162 0.0306 0.1615
Loa Loa (eye worm) TK/Met protein kinase 0.0056 0.0063 0.0063
Brugia malayi Dynamin 0.0065 0.0083 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0711 0.1566 0.1566
Onchocerca volvulus 0.0056 0.0063 0.0325
Echinococcus granulosus epidermal growth factor receptor 0.0056 0.0063 0.0075
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0074 0.0103 0.0123
Trichomonas vaginalis centaurin alpha, putative 0.0065 0.0083 0.0408
Trichomonas vaginalis AGC family protein kinase 0.0077 0.011 0.0577
Trichomonas vaginalis protein kinase atn1, putative 0.0056 0.0063 0.0275
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0369 0.0782 0.0782
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni oxysterol-binding protein 1 0.0065 0.0083 0.0083
Onchocerca volvulus 0.0056 0.0063 0.0325
Echinococcus granulosus tyrosine protein kinase HCK 0.0056 0.0063 0.0075
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Trypanosoma cruzi hypothetical protein 0.0065 0.0083 0.3378
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0065 0.0083 0.0137
Echinococcus granulosus receptor type guanylyl cyclase 0.0056 0.0063 0.0075
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0065 0.0083 0.3378
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0065 0.0083 0.01
Schistosoma mansoni zinc finger protein 0.0065 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Trypanosoma cruzi hypothetical protein 0.0065 0.0083 0.3378
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0065 0.0083 0.3378
Loa Loa (eye worm) uncoordinated protein 104 0.0065 0.0083 0.0083
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0056 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0065 0.0083 0.0137
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis actin binding protein anillin 0.0065 0.0083 0.01
Echinococcus multilocularis oxysterol binding protein 9 0.0065 0.0083 0.01
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0056 0.0063 0.0063
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0074 0.0103 0.0123
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0083 0.0124 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0056 0.0063 0.0075
Echinococcus multilocularis cytohesin 1 0.0065 0.0083 0.01
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0056 0.0063 0.0063
Echinococcus granulosus oxysterol binding protein 1 0.0065 0.0083 0.01
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0065 0.0083 0.0083
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0077 0.011 0.031
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis protein transport protein sec7, putative 0.0065 0.0083 0.0408
Echinococcus granulosus retinal guanylyl cyclase 2 0.0056 0.0063 0.0075
Echinococcus multilocularis natriuretic peptide receptor 1 0.0056 0.0063 0.0075
Echinococcus multilocularis Rho GTPase activating protein 24 0.0065 0.0083 0.01
Schistosoma mansoni protein kinase 0.0056 0.0063 0.0063
Brugia malayi protein-tyrosine kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/ABL protein kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0056 0.0063 0.0075
Echinococcus multilocularis tyrosine kinase 0.0056 0.0063 0.0075
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0083 0.0124 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0083 0.0124 1
Schistosoma mansoni plexin 0.0871 0.1934 0.1934
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0065 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0056 0.0063 0.0075
Leishmania major protein kinase, putative 0.0083 0.0124 1
Loa Loa (eye worm) SRC-1 0.0056 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Onchocerca volvulus 0.0056 0.0063 0.0325
Echinococcus granulosus epidermal growth factor receptor 0.0056 0.0063 0.0075
Loa Loa (eye worm) hypothetical protein 0.0114 0.0197 0.0197
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) protein kinase domain-containing protein 0.0056 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase Src42A 0.0056 0.0063 0.0075
Echinococcus granulosus integrin linked protein kinase 0.0056 0.0063 0.0075
Brugia malayi Oxysterol-binding protein 0.0065 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) TK/DDR protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni serine/threonine RGC 0.0056 0.0063 0.0063
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3672 0.8368 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Echinococcus granulosus myotubularin protein 13 0.0065 0.0083 0.01
Echinococcus granulosus tyrosine protein kinase pr2 0.0056 0.0063 0.0075
Echinococcus granulosus tyrosine protein kinase csk 0.0056 0.0063 0.0075
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0056 0.0063 0.0063
Entamoeba histolytica protein kinase domain containing protein 0.0218 0.0435 0.2474
Trichomonas vaginalis centaurin/arf, putative 0.0065 0.0083 0.0408
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0065 0.0083 0.0408
Loa Loa (eye worm) hypothetical protein 0.0711 0.1566 0.1566
Brugia malayi A-kinase anchor protein 10, precursor 0.0711 0.1566 0.1566
Loa Loa (eye worm) hypothetical protein 0.0369 0.0782 0.0782
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0056 0.0063 0.0075
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Echinococcus granulosus raf serine:threonine protein kinase 0.0056 0.0063 0.0075
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0056 0.0063 0.0075
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0074 0.0103 0.6622
Echinococcus granulosus roundabout 2 0.0119 0.0208 0.0249
Plasmodium falciparum calcium-dependent protein kinase 7 0.0083 0.0124 1
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus granulosus dynamin 1 0.0065 0.0083 0.01
Toxoplasma gondii phosphatidylinositol transfer protein 0.0065 0.0083 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0074 0.0103 0.6622
Loa Loa (eye worm) hypothetical protein 0.0162 0.0306 0.0306
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.0063 0.0075
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0065 0.0083 0.0083
Brugia malayi hypothetical protein 0.0056 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0114 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0056 0.0063 0.0275
Brugia malayi Furin-like cysteine rich region family protein 0.0056 0.0063 0.0063
Brugia malayi Cytohesin 3 0.0065 0.0083 0.0083
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0056 0.0063 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0056 0.0063 0.0075
Echinococcus granulosus DCC interacting protein 13 beta 0.0065 0.0083 0.01
Trypanosoma cruzi hypothetical protein 0.0065 0.0083 0.3378
Brugia malayi regulator of G-protein signaling rgs-7 0.0711 0.1566 0.1566
Echinococcus granulosus Rho GTPase activating protein 24 0.0065 0.0083 0.01
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0077 0.011 0.7655
Loa Loa (eye worm) sema domain-containing protein 0.0369 0.0782 0.0782
Onchocerca volvulus 0.0065 0.0083 0.0432
Brugia malayi Receptor family ligand binding region containing protein 0.0056 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0306 0.1845
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0114 0.0197 0.0197
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Entamoeba histolytica cell surface protease gp63, putative 0.0162 0.0306 0.1615
Trypanosoma brucei protein kinase, putative 0.0083 0.0124 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0056 0.0063 0.0063
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0026 0.0026
Echinococcus granulosus calcium dependent secretion activator 1 0.0065 0.0083 0.01
Entamoeba histolytica protein kinase, putative 0.0083 0.0124 0.0406
Leishmania major hypothetical protein, conserved 0.0065 0.0083 0.3378
Leishmania major protein kinase, putative 0.0074 0.0103 0.6622
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis activin receptor type 0.0074 0.0103 0.0123
Brugia malayi Immunoglobulin I-set domain containing protein 0.0171 0.0326 0.0326
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis AGC family protein kinase 0.0077 0.011 0.0577
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Brugia malayi PH domain containing protein 0.0065 0.0083 0.0083
Echinococcus granulosus activin receptor type 0.0074 0.0103 0.0123
Echinococcus multilocularis axis inhibition protein axin 0.0711 0.1566 0.1871
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis Immunoglobulin 0.0114 0.0197 0.0235
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Brugia malayi serine/threonine kinase 12 0.0077 0.011 0.011
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0065 0.0083 0.0137
Echinococcus multilocularis regulator of G protein signaling 0.0711 0.1566 0.1871
Schistosoma mansoni hypothetical protein 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Brugia malayi PH domain containing protein 0.0065 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0063 0.0275
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0026 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Entamoeba histolytica p21-activated kinase 0.0083 0.0124 0.0406
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0077 0.011 0.0131
Trypanosoma brucei protein kinase, putative 0.0074 0.0103 0.6622
Loa Loa (eye worm) hypothetical protein 0.0162 0.0306 0.0306
Brugia malayi PH domain containing protein 0.0065 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0056 0.0063 0.0063
Trypanosoma cruzi PH domain containing protein, putative 0.0065 0.0083 0.3378
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus granulosus neuroglian 0.0114 0.0197 0.0235
Entamoeba histolytica hypothetical protein 0.0065 0.0083 0.0137
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0065 0.0083 0.0432
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis neuroglian 0.0114 0.0197 0.0235
Echinococcus granulosus beta-adrenergic receptor kinase 0.3359 0.765 0.9142
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Schistosoma mansoni ephrin receptor 0.0061 0.0074 0.0074
Trichomonas vaginalis hypothetical protein 0.0065 0.0083 0.0408
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis tyrosine protein kinase Abl 0.0056 0.0063 0.0075
Brugia malayi bone morphogenetic protein type 1 receptor 0.0056 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Entamoeba histolytica ARF GTPase activating protein, putative 0.0065 0.0083 0.0137
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0083 0.0124 1
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0083 0.0124 1
Entamoeba histolytica protein kinase, putative 0.0083 0.0124 0.0406
Echinococcus multilocularis epidermal growth factor receptor 0.0056 0.0063 0.0075
Onchocerca volvulus 0.0065 0.0083 0.0432
Echinococcus multilocularis tyrosine protein kinase Srms 0.0056 0.0063 0.0075
Echinococcus granulosus tyrosine kinase 0.0056 0.0063 0.0075
Brugia malayi hypothetical protein 0.0119 0.0208 0.0208
Echinococcus multilocularis Pleckstrin y 0.0065 0.0083 0.01
Echinococcus granulosus axis inhibition protein axin 0.0711 0.1566 0.1871
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0065 0.0083 0.0137
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0162 0.0306 0.0306
Onchocerca volvulus 0.0056 0.0063 0.0325
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0056 0.0063 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.3359 0.765 0.765
Entamoeba histolytica PH domain containing protein kinase, putative 0.0083 0.0124 0.0406
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Brugia malayi IPT/TIG domain containing protein 0.0162 0.0306 0.0306
Brugia malayi SRC-1 0.0056 0.0063 0.0063
Trichomonas vaginalis centaurin beta, putative 0.0065 0.0083 0.0408
Trypanosoma cruzi hypothetical protein 0.0065 0.0083 0.3378
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.0063 0.0075
Schistosoma mansoni protein kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0056 0.0063 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Onchocerca volvulus 0.0056 0.0063 0.0325
Loa Loa (eye worm) hypothetical protein 0.0119 0.0208 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0711 0.1566 1
Onchocerca volvulus 0.0065 0.0083 0.0432
Echinococcus granulosus Regulator of G protein signaling 20 0.0711 0.1566 0.1871
Onchocerca volvulus 0.0056 0.0063 0.0325
Entamoeba histolytica PH domain containing protein 0.0065 0.0083 0.0137
Onchocerca volvulus 0.0056 0.0063 0.0325
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0074 0.0103 0.6622
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3359 0.765 0.765
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0711 0.1566 0.1871
Trypanosoma cruzi aurora B kinase, putative 0.0077 0.011 0.7655
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Loa Loa (eye worm) rho-GTPase-activating 0.0065 0.0083 0.0083
Plasmodium vivax PH domain containing protein 0.0065 0.0083 0.3378
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Brugia malayi hypothetical protein 0.0065 0.0083 0.0083
Echinococcus granulosus fibroblast growth factor receptor 4 0.0056 0.0063 0.0075
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0711 0.1566 0.1566
Schistosoma mansoni protein kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis protein kinase 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Brugia malayi Protein kinase domain containing protein 0.0083 0.0124 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus granulosus regulator of G protein signaling 7 0.0711 0.1566 0.1871
Loa Loa (eye worm) hypothetical protein 0.0369 0.0782 0.0782
Brugia malayi Regulator of G protein signaling domain containing protein 0.0711 0.1566 0.1566
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0056 0.0063 0.0075
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0063 0.0075
Brugia malayi Protein kinase domain containing protein 0.0297 0.0616 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0711 0.1566 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0077 0.011 0.031
Brugia malayi PXA domain containing protein 0.0711 0.1566 0.1566
Entamoeba histolytica protein kinase, putative 0.0083 0.0124 0.0406
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0065 0.0083 0.0137
Echinococcus granulosus regulator of G protein signaling 7 0.0711 0.1566 0.1871
Echinococcus granulosus Pleckstrin y 0.0065 0.0083 0.01
Echinococcus multilocularis Ras associated and pleckstrin y 0.0065 0.0083 0.01
Entamoeba histolytica protein kinase , putative 0.0077 0.011 0.031
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) AGC/AKT protein kinase 0.0083 0.0124 0.0124
Loa Loa (eye worm) AUR protein kinase 0.0077 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Brugia malayi ephrin receptor 1 precursor 0.0056 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0306 0.1845
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0056 0.0063 0.0075
Echinococcus granulosus retinal guanylyl cyclase 2 0.0056 0.0063 0.0075
Schistosoma mansoni oxysterol-binding protein 1 0.0065 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Schistosoma mansoni ephrin receptor 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/EGFR protein kinase 0.0056 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus granulosus pleckstrin y domain containing family A 0.0065 0.0083 0.01
Loa Loa (eye worm) hypothetical protein 0.0212 0.0421 0.0421
Plasmodium falciparum PH domain-containing protein, putative 0.0065 0.0083 0.3378
Brugia malayi plexin A 0.1033 0.2306 0.2306
Echinococcus multilocularis expressed protein 0.0711 0.1566 0.1871
Schistosoma mansoni zinc finger protein 0.0065 0.0083 0.0083
Brugia malayi Probable exocyst complex component Sec5 0.0162 0.0306 0.0306
Schistosoma mansoni fibrocystin l 0.0162 0.0306 0.0306
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0063 0.0063
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0065 0.0083 0.01
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0063 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Loa Loa (eye worm) Plekhf2 protein 0.0065 0.0083 0.0083
Brugia malayi C-terminal src kinase protein 1 0.0056 0.0063 0.0063
Trypanosoma brucei aurora B kinase 0.0077 0.011 0.7655
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0077 0.011 0.0131
Brugia malayi SH2 domain containing protein 0.0056 0.0063 0.0063
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0056 0.0063 0.0063
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0083 0.0124 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0083 0.0124 0.0406
Loa Loa (eye worm) hypothetical protein 0.0114 0.0197 0.0197
Schistosoma mansoni semaphorin 5-related 0.0369 0.0782 0.0782
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0056 0.0063 0.0075
Brugia malayi serine/threonine-protein kinase 6 0.0077 0.011 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0306 0.1845
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis calcium dependent secretion activator 1 0.0065 0.0083 0.01
Schistosoma mansoni nephrin 0.0119 0.0208 0.0208
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni centaurin alpha 0.0065 0.0083 0.0083
Echinococcus multilocularis beta 1 syntrophin 0.0065 0.0083 0.01
Brugia malayi Tyrosine-protein kinase PR2 0.0056 0.0063 0.0063
Echinococcus multilocularis epidermal growth factor receptor 0.0056 0.0063 0.0075
Loa Loa (eye worm) TK/CSK protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Entamoeba histolytica protein kinase, putative 0.0083 0.0124 0.0406
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0065 0.0083 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0063 0.0075
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3672 0.8368 0.8368
Echinococcus multilocularis oxysterol binding protein 3 0.0065 0.0083 0.01
Schistosoma mansoni protein kinase 0.0074 0.0103 0.0103
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0083 0.3378
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3672 0.8368 0.8368
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0056 0.0063 0.0063
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0083 0.0124 1
Echinococcus multilocularis c src tyrosine kinase 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0083 0.0124 1
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0035 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0065 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0063 0.0275
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis Regulator of G protein signaling 20 0.0711 0.1566 0.1871
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0306 0.1845
Echinococcus granulosus Pleckstrin y 0.0065 0.0083 0.01
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0056 0.0063 0.0075
Echinococcus multilocularis kinase suppressor of Ras 1 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase shark 0.0056 0.0063 0.0075
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.0063 0.0075
Loa Loa (eye worm) hypothetical protein 0.0871 0.1934 0.1934
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis roundabout 2 0.0119 0.0208 0.0249
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Trichomonas vaginalis centaurin gamma, putative 0.0065 0.0083 0.0408
Schistosoma mansoni growth factor receptor-bound protein 0.0065 0.0083 0.0083
Brugia malayi MAX-1A 0.0065 0.0083 0.0083
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0065 0.0083 0.3378
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Entamoeba histolytica hypothetical protein 0.0162 0.0306 0.1615
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0056 0.0063 0.0275
Loa Loa (eye worm) hypothetical protein 0.0501 0.1086 0.1086
Echinococcus multilocularis plexin a4 0.1033 0.2306 0.2756
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Echinococcus granulosus c src tyrosine kinase 0.0056 0.0063 0.0075
Entamoeba histolytica hypothetical protein 0.0162 0.0306 0.1615
Schistosoma mansoni tyrosine protein kinase 0.0056 0.0063 0.0063
Plasmodium falciparum protein kinase, putative 0.0074 0.0103 0.6622
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Brugia malayi Plekhf2 protein 0.0065 0.0083 0.0083
Echinococcus multilocularis tyrosine protein kinase 0.0056 0.0063 0.0075
Schistosoma mansoni protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni cell adhesion molecule 0.0119 0.0208 0.0208
Echinococcus multilocularis dynamin 1 0.0065 0.0083 0.01
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Echinococcus granulosus insulin receptor 0.0056 0.0063 0.0075
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus granulosus tyrosine kinase 0.0056 0.0063 0.0075
Echinococcus multilocularis Oxysterol binding protein 11 0.0065 0.0083 0.01
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis protein tyrosine kinase 0.0056 0.0063 0.0075
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Brugia malayi Sema domain containing protein 0.0369 0.0782 0.0782
Schistosoma mansoni regulator of G protein signaling 0.0711 0.1566 0.1566
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Brugia malayi PXA domain containing protein 0.0711 0.1566 0.1566
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0056 0.0063 0.0075
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0065 0.0083 0.0408
Loa Loa (eye worm) PH domain-containing protein 0.0065 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Schistosoma mansoni myotubularin-related protein 0.0065 0.0083 0.0083
Schistosoma mansoni vesicular amine transporter 0.0117 0.0203 0.0203
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0056 0.0063 0.0075
Giardia lamblia Aurora kinase 0.0077 0.011 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Entamoeba histolytica hypothetical protein 0.0065 0.0083 0.0137
Onchocerca volvulus Putative zinc finger protein 0.0065 0.0083 0.0432
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Onchocerca volvulus 0.0056 0.0063 0.0325
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trypanosoma brucei PH domain containing protein, putative 0.0065 0.0083 0.3378
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0056 0.0063 0.0275
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Echinococcus multilocularis protein KINase family member (kin 25) 0.0056 0.0063 0.0075
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3672 0.8368 1
Echinococcus granulosus semaphorin 1A 0.0369 0.0782 0.0935
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0065 0.0083 0.01
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0065 0.0083 0.0137
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Leishmania major protein kinase, putative 0.0077 0.011 0.7655
Entamoeba histolytica hypothetical protein 0.0065 0.0083 0.0137
Entamoeba histolytica hypothetical protein, conserved 0.0065 0.0083 0.0137
Loa Loa (eye worm) TK/INSR protein kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis protein transport protein sec7, putative 0.0065 0.0083 0.0408
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Entamoeba histolytica PH domain containing protein kinase, putative 0.0083 0.0124 0.0406
Echinococcus granulosus Oxysterol binding protein 11 0.0065 0.0083 0.01
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Trypanosoma cruzi hypothetical protein 0.0065 0.0083 0.3378
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0056 0.0063 0.0325
Schistosoma mansoni axis inhibition protein axin 0.0711 0.1566 0.1566
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0306 0.1845
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0065 0.0083 0.3378
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Onchocerca volvulus outspread protein homolog 0.0065 0.0083 0.0432
Echinococcus granulosus activated cdc42 kinase 1 0.0056 0.0063 0.0075
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0171 0.0326 0.0326
Entamoeba histolytica hypothetical protein 0.0711 0.1566 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0065 0.0083 0.01
Echinococcus multilocularis heat shock protein 70 0.0056 0.0063 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0077 0.011 0.031
Schistosoma mansoni goodpasture antigen-binding protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Onchocerca volvulus 0.0065 0.0083 0.0432
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0114 0.0197 0.0235
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0056 0.0063 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0306 0.1845
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis receptor type guanylyl cyclase 0.0056 0.0063 0.0075
Onchocerca volvulus Protein melted homolog 0.0065 0.0083 0.0432
Schistosoma mansoni axis inhibition protein axin 0.0711 0.1566 0.1566
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0306 0.1845
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Brugia malayi PH domain containing protein 0.0065 0.0083 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Leishmania major folate/biopterin transporter, putative 0.0083 0.0124 1
Onchocerca volvulus 0.0056 0.0063 0.0325
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0035 0.0035
Trichomonas vaginalis alpha chimerin, putative 0.0065 0.0083 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) hypothetical protein 0.0711 0.1566 0.1566
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0056 0.0063 0.0063
Echinococcus granulosus kinase suppressor of Ras 1 0.0056 0.0063 0.0075
Schistosoma mansoni regulator of G protein signaling 0.0711 0.1566 0.1566
Echinococcus multilocularis integrin linked protein kinase 0.0056 0.0063 0.0075
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0711 0.1566 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0056 0.0063 0.0075
Echinococcus granulosus cytohesin 1 0.0065 0.0083 0.01
Echinococcus multilocularis hypothetical protein 0.0369 0.0782 0.0935
Echinococcus granulosus oxysterol binding protein 3 0.0065 0.0083 0.01
Onchocerca volvulus 0.0056 0.0063 0.0325
Echinococcus multilocularis GRB2 associated binding protein 3 0.0065 0.0083 0.01
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0056 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0056 0.0063 0.0075
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0711 0.1566 0.1566
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0065 0.0083 0.0137
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Echinococcus multilocularis regulator of G protein signaling 3 0.0711 0.1566 0.1871
Loa Loa (eye worm) TK/FAK protein kinase 0.0056 0.0063 0.0063
Entamoeba histolytica protein kinase, putative 0.0083 0.0124 0.0406
Onchocerca volvulus 0.0056 0.0063 0.0325
Loa Loa (eye worm) hypothetical protein 0.0162 0.0306 0.0306
Echinococcus multilocularis insulin receptor 0.0056 0.0063 0.0075
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0056 0.0063 0.0075
Brugia malayi Uncoordinated protein 104 0.0065 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0035 0.0014 0.0014
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0065 0.0083 0.0083
Toxoplasma gondii AtPH1 family protein 0.0065 0.0083 0.3378
Loa Loa (eye worm) AUR protein kinase 0.0077 0.011 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Loa Loa (eye worm) syntrophin-1 0.0065 0.0083 0.0083
Brugia malayi Tyrosine-protein kinase abl-1 0.0056 0.0063 0.0063
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3672 0.8368 0.8368
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0056 0.0063 0.0075
Trichomonas vaginalis centaurin/arf, putative 0.0065 0.0083 0.0408
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0056 0.0063 0.0075
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis Pleckstrin y 0.0065 0.0083 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0306 0.1845
Trichomonas vaginalis AGC family protein kinase 0.0077 0.011 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Echinococcus granulosus Pleckstrin y 0.0065 0.0083 0.01
Onchocerca volvulus 0.0871 0.1934 1
Echinococcus granulosus transcription factor collier 0.0162 0.0306 0.0365
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0083 0.0124 0.0669
Brugia malayi SH2 domain containing protein 0.0056 0.0063 0.0063
Loa Loa (eye worm) PXA domain-containing protein 0.0711 0.1566 0.1566
Toxoplasma gondii aurora kinase 0.0077 0.011 0.7655
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0083 0.0124 1
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0306 0.1845
Loa Loa (eye worm) plexin A 0.1033 0.2306 0.2306
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0056 0.0063 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Trypanosoma cruzi PH domain containing protein, putative 0.0065 0.0083 0.3378
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0711 0.1566 0.1871
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0063 0.0275
Loa Loa (eye worm) hypothetical protein 0.0369 0.0782 0.0782
Echinococcus granulosus aurora kinase A 0.0077 0.011 0.0131
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0056 0.0063 0.0075
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0056 0.0063 0.0075
Brugia malayi PH domain containing protein 0.0065 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0063 0.0075
Entamoeba histolytica hypothetical protein 0.0065 0.0083 0.0137
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0065 0.0083 0.0083
Schistosoma mansoni protein kinase 0.0077 0.011 0.011
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus multilocularis regulator of G protein signaling 7 0.0711 0.1566 0.1871
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0065 0.0083 0.3378
Loa Loa (eye worm) hypothetical protein 0.0114 0.0197 0.0197
Brugia malayi Cadps2 protein 0.0065 0.0083 0.0083
Echinococcus granulosus defective proboscis extension response 0.0114 0.0197 0.0235
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0056 0.0063 0.0075
Leishmania major serine/threonine-protein kinase a, putative 0.0083 0.0124 1
Entamoeba histolytica hypothetical protein 0.0711 0.1566 1
Brugia malayi Oxysterol binding protein 0.0065 0.0083 0.0083
Echinococcus granulosus pdz domain containing protein 0.0065 0.0083 0.01
Echinococcus multilocularis tyrosine protein kinase HCK 0.0056 0.0063 0.0075
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0065 0.0083 0.0137
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0065 0.0083 0.0137
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Loa Loa (eye worm) sema domain-containing protein 0.0369 0.0782 0.0782
Echinococcus multilocularis protein kinase 0.0056 0.0063 0.0075
Entamoeba histolytica hypothetical protein 0.0083 0.0124 0.0406
Entamoeba histolytica PH domain containing protein 0.0065 0.0083 0.0137
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0056 0.0063 0.0063
Onchocerca volvulus 0.0056 0.0063 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Entamoeba histolytica hypothetical protein 0.0711 0.1566 1
Trypanosoma cruzi Protein kinase B 0.0083 0.0124 1
Schistosoma mansoni z-protein (S1r protein) 0.0711 0.1566 0.1566
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine kinase 0.0056 0.0063 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0306 0.1845
Schistosoma mansoni protein tyrosine kinase 0.0056 0.0063 0.0063
Toxoplasma gondii Oxysterol-binding protein 0.0065 0.0083 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Brugia malayi Raf kinase 0.0056 0.0063 0.0063
Brugia malayi PH domain containing protein 0.0065 0.0083 0.0083
Echinococcus multilocularis raf serine:threonine protein kinase 0.0056 0.0063 0.0075
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0065 0.0083 0.0408
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0056 0.0063 0.0075
Trichomonas vaginalis TK family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis axis inhibition protein axin 0.0711 0.1566 0.1871
Brugia malayi PH domain containing protein 0.0065 0.0083 0.0083
Onchocerca volvulus 0.0369 0.0782 0.4045
Entamoeba histolytica PH domain containing protein kinase, putative 0.0083 0.0124 0.0406
Echinococcus granulosus G protein coupled receptor kinase 1 0.2648 0.6018 0.7191
Echinococcus multilocularis semaphorin 5B 0.0369 0.0782 0.0935
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0056 0.0063 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Brugia malayi Syntrophin-1 0.0065 0.0083 0.0083
Echinococcus multilocularis beta adrenergic receptor kinase 0.3359 0.765 0.9142
Schistosoma mansoni goodpasture antigen-binding protein 0.0065 0.0083 0.0083
Echinococcus granulosus tyrosine protein kinase Lyn 0.0074 0.0103 0.0123
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0711 0.1566 0.1566
Loa Loa (eye worm) TK/ALK protein kinase 0.0297 0.0616 0.0616
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0065 0.0083 0.3378
Entamoeba histolytica protein kinase, putative 0.0083 0.0124 0.0406
Entamoeba histolytica protein kinase domain containing protein 0.0077 0.011 0.031
Brugia malayi hypothetical protein 0.0369 0.0782 0.0782
Echinococcus granulosus axis inhibition protein axin 0.0711 0.1566 0.1871
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0083 0.0124 1
Brugia malayi hypothetical protein 0.0711 0.1566 0.1566
Schistosoma mansoni dynamin 0.0065 0.0083 0.0083
Brugia malayi hypothetical protein 0.0369 0.0782 0.0782
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.0063 0.0063
Echinococcus granulosus Immunoglobulin 0.0114 0.0197 0.0235
Echinococcus granulosus tyrosine protein kinase ABL1 0.0056 0.0063 0.0075
Echinococcus granulosus GRB2 associated binding protein 3 0.0065 0.0083 0.01
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0083 0.0124 1
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0065 0.0083 0.01
Echinococcus granulosus expressed protein 0.0711 0.1566 0.1871
Echinococcus multilocularis exocyst complex component 2 0.0162 0.0306 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0063 0.0275
Echinococcus granulosus plexin a4 0.1033 0.2306 0.2756
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0065 0.0083 0.01
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0074 0.0103 0.6622
Echinococcus granulosus exocyst complex component 2 0.0162 0.0306 0.0365
Loa Loa (eye worm) hypothetical protein 0.0369 0.0782 0.0782
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0065 0.0083 0.0137
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0065 0.0083 0.0083
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0065 0.0083 0.01
Schistosoma mansoni serine/threonine-protein kinase 0.0083 0.0124 0.0124
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0061 0.0074 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.3359 0.765 0.765
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0065 0.0083 0.01
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Loa Loa (eye worm) RGS-3 protein 0.0711 0.1566 0.1566
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/RYK protein kinase 0.0056 0.0063 0.0063
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0065 0.0083 0.0137
Echinococcus multilocularis regulator of G protein signaling 3 0.0711 0.1566 0.1871
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0083 0.0124 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0056 0.0063 0.0075
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0083 0.0124 1
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0065 0.0083 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trypanosoma cruzi hypothetical protein 0.0065 0.0083 0.3378
Echinococcus multilocularis tyrosine protein kinase Blk 0.0056 0.0063 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Brugia malayi Fibronectin type III domain containing protein 0.0119 0.0208 0.0208
Schistosoma mansoni regulator of G protein signaling 0.0711 0.1566 0.1566
Echinococcus granulosus tyrosine protein kinase csk 0.0056 0.0063 0.0075
Schistosoma mansoni hypothetical protein 0.0369 0.0782 0.0782
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0065 0.0083 0.01
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Entamoeba histolytica tyrosin kinase, putative 0.0218 0.0435 0.2474
Brugia malayi PH domain containing protein 0.0065 0.0083 0.0083
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0065 0.0083 0.01
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Brugia malayi TBC domain containing protein 0.0065 0.0083 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0063 0.0063
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0065 0.0083 0.0137
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0711 0.1566 0.1566
Entamoeba histolytica PH domain containing protein kinase, putative 0.0083 0.0124 0.0406
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Brugia malayi Variant SH3 domain containing protein 0.0065 0.0083 0.0083
Echinococcus granulosus tyrosine protein kinase Blk 0.0056 0.0063 0.0075
Brugia malayi Plexin repeat family protein 0.0871 0.1934 0.1934
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0026 0.0032
Onchocerca volvulus 0.0034 0.0011 0.0059
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Onchocerca volvulus 0.0056 0.0063 0.0325
Onchocerca volvulus 0.0065 0.0083 0.0432
Echinococcus granulosus protein tyrosine kinase 0.0056 0.0063 0.0075
Loa Loa (eye worm) hypothetical protein 0.0119 0.0208 0.0208
Echinococcus multilocularis Immunoglobulin 0.0114 0.0197 0.0235
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0056 0.0063 0.0063
Onchocerca volvulus Tyrosine kinase homolog 0.0056 0.0063 0.0325
Brugia malayi Guanylyl cyclase protein 23 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus granulosus regulator of G protein signaling 3 0.0711 0.1566 0.1871
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0056 0.0063 0.0075
Schistosoma mansoni hypothetical protein 0.0501 0.1086 0.1086
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis activated cdc42 kinase 1 0.0056 0.0063 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0711 0.1566 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0006 0.0006
Echinococcus multilocularis ephrin type A receptor 4 A 0.0056 0.0063 0.0075
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0083 0.0124 1
Brugia malayi serine/threonine protein kinase 6 0.0077 0.011 0.011
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Loa Loa (eye worm) hypothetical protein 0.0369 0.0782 0.0782
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0711 0.1566 0.1566
Schistosoma mansoni regulator of G protein signaling 0.0711 0.1566 0.1566
Brugia malayi integrin-linked kinase 0.0056 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0083 0.0124 0.0406
Trypanosoma cruzi PH domain containing protein, putative 0.0065 0.0083 0.3378
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0083 0.0124 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0711 0.1566 0.1871
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0065 0.0083 0.0432
Schistosoma mansoni dynamin 0.0065 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Schistosoma mansoni protein kinase 0.0056 0.0063 0.0063
Trypanosoma cruzi NIMA-related kinase, putative 0.0083 0.0124 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0083 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0306 0.1845
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0103 0.0269
Schistosoma mansoni serine/threonine-protein kinase 0.0083 0.0124 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0711 0.1566 1
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0083 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0369 0.0782 0.0782
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus granulosus regulator of G protein signaling 3 0.0711 0.1566 0.1871
Schistosoma mansoni syntrophin 0.0065 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Plasmodium falciparum oxysterol-binding protein, putative 0.0065 0.0083 0.3378
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase pr2 0.0056 0.0063 0.0075
Loa Loa (eye worm) hypothetical protein 0.0711 0.1566 0.1566
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0065 0.0083 0.0137
Schistosoma mansoni protein kinase 0.0074 0.0103 0.0103
Echinococcus multilocularis rac serine:threonine kinase 0.0083 0.0124 0.0148
Toxoplasma gondii hypothetical protein 0.0065 0.0083 0.3378
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0056 0.0063 0.0275
Brugia malayi hypothetical protein 0.0711 0.1566 0.1566
Brugia malayi DNA-binding protein LAG-1 0.0162 0.0306 0.0306
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Leishmania major protein kinase, putative 0.0083 0.0124 1
Echinococcus multilocularis pdz domain containing protein 0.0065 0.0083 0.01
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0065 0.0083 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Echinococcus multilocularis myotubularin protein 13 0.0065 0.0083 0.01
Trypanosoma cruzi hypothetical protein 0.0065 0.0083 0.3378
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus granulosus oxysterol binding protein 9 0.0065 0.0083 0.01
Schistosoma mansoni protein kinase 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0065 0.0083 0.01
Echinococcus granulosus tyrosine protein kinase csk 0.0056 0.0063 0.0075
Schistosoma mansoni hypothetical protein 0.0065 0.0083 0.0083
Echinococcus granulosus tyrosine protein kinase 0.0056 0.0063 0.0075
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0065 0.0083 0.0408
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0114 0.0197 0.0235
Entamoeba histolytica protein kinase, putative 0.0077 0.011 0.031
Schistosoma mansoni protein kinase 0.0074 0.0103 0.0103
Echinococcus multilocularis Pleckstrin y 0.0065 0.0083 0.01
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0162 0.0306 0.0306
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0208 0.0208
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0056 0.0063 0.0075
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0083 0.0124 1
Schistosoma mansoni tyrosine kinase 0.0056 0.0063 0.0063
Brugia malayi Dynamin 0.0065 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Loa Loa (eye worm) TK protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Onchocerca volvulus 0.0065 0.0083 0.0432
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0056 0.0063 0.0075
Brugia malayi Protein kinase domain containing protein 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0063 0.0063
Brugia malayi Sema domain containing protein 0.0369 0.0782 0.0782
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0056 0.0063 0.0063
Brugia malayi regulator of G-protein signaling egl-10 0.0711 0.1566 0.1566
Echinococcus granulosus tyrosine protein kinase shark 0.0056 0.0063 0.0075
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0056 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275
Echinococcus multilocularis oxysterol binding protein 1 0.0065 0.0083 0.01
Schistosoma mansoni regulator of G protein signaling 0.0711 0.1566 0.1566
Brugia malayi PH domain containing protein 0.0065 0.0083 0.0083
Brugia malayi hypothetical protein 0.0056 0.0063 0.0063
Echinococcus granulosus beta 1 syntrophin 0.0065 0.0083 0.01
Schistosoma mansoni plexin 0.0501 0.1086 0.1086
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0063 0.0275
Entamoeba histolytica hypothetical protein 0.0065 0.0083 0.0137
Echinococcus multilocularis pleckstrin y domain containing family A 0.0065 0.0083 0.01
Brugia malayi probable spectrin beta chain 0.0065 0.0083 0.0083
Trichomonas vaginalis STE family protein kinase 0.0056 0.0063 0.0275
Brugia malayi hypothetical protein 0.0056 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0124 0.0669
Loa Loa (eye worm) hypothetical protein 0.0119 0.0208 0.0208
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0063 0.0275

Activities

Activity type Activity value Assay description Source Reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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