Detailed information for compound 140221

Basic information

Technical information
  • TDR Targets ID: 140221
  • Name: 10b-phenyl-1,2,3,4-tetrahydropyrimido[1,2-b]i soindol-6-one
  • MW: 264.322 | Formula: C17H16N2O
  • H donors: 1 H acceptors: 1 LogP: 2.27 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1c2ccccc2C2(N1CCCN2)c1ccccc1
  • InChi: 1S/C17H16N2O/c20-16-14-9-4-5-10-15(14)17(13-7-2-1-3-8-13)18-11-6-12-19(16)17/h1-5,7-10,18H,6,11-12H2
  • InChiKey: PJMQDIXGYNLHIK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 10b-Phenyl-1,3,4,10b-tetrahydro-2H-pyrimido[2,1-a]isoindol-6-one
  • BAS 10320875
  • SMR000290511
  • ST5290091
  • MLS000718243
  • AIDS-005593
  • AIDS005593
  • Pyrimido[2,1-a]isoindol-6(2H)-one, 1,3,4,10b-tetrahydro-10b-phenyl-
  • Pyrimidoloisoindol-6-one, Ph deriv.
  • Thiazoloisoindol-5-one deriv. 37

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0078 0.0291 0.151
Leishmania major calpain family cysteine protease-like protein 0.0039 0.0077 0.04
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0089 0.152
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0209 0.0347
Schistosoma mansoni neuronal calcium sensor 0.0029 0.002 0.0022
Echinococcus granulosus calpain A 0.0376 0.1942 0.2494
Schistosoma mansoni hypothetical protein 0.0086 0.0335 0.0535
Giardia lamblia Hypothetical protein 0.0041 0.0089 0.0426
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0056 0.0171 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Trichomonas vaginalis calmodulin-2, putative 0.0029 0.002 0.007
Echinococcus multilocularis chromobox protein 1 0.0068 0.0234 0.0292
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0456 0.0456
Entamoeba histolytica cysteine protease, putative 0.0041 0.0089 0.1962
Schistosoma mansoni calmodulin 0.0029 0.002 0.0022
Trichomonas vaginalis fk506-binding protein, putative 0.0052 0.0149 0.0741
Plasmodium vivax vivapain-2 0.0078 0.0291 0.4984
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.067 0.1081
Brugia malayi Cathepsin L-like precursor 0.0078 0.0291 0.0291
Echinococcus granulosus cathepsin L 0.0056 0.0171 0.0211
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0584 0.0968
Trichomonas vaginalis calcium binding protein, putative 0.0035 0.0054 0.0243
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0053 0.0074
Brugia malayi hypothetical protein 0.0035 0.0053 0.0053
Schistosoma mansoni integrin alpha 0.0179 0.0852 0.1377
Trypanosoma cruzi cruzipain precursor, putative 0.0078 0.0291 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.003 0.0023 0.0038
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.0584 0.0968
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Echinococcus multilocularis calpain family protein 1, d 0.0255 0.1273 0.1633
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0039 0.0077 0.0365
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.0089 0.0147
Giardia lamblia Cathepsin B precursor 0.0373 0.1927 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0039 0.0077 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0089 0.0426
Echinococcus granulosus programmed cell death protein 6 0.0035 0.0054 0.006
Loa Loa (eye worm) calpain 5 0.0091 0.0366 0.0366
Giardia lamblia Cathepsin B precursor 0.0041 0.0089 0.0426
Giardia lamblia Tenascin-like 0.0062 0.0203 0.1021
Schistosoma mansoni hypothetical protein 0.0029 0.002 0.0022
Echinococcus granulosus cathepsin L cysteine protease 0.0056 0.0171 0.0211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0888 0.1136
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0089
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0007 0.0012
Echinococcus granulosus centrin 2 0.0029 0.002 0.0017
Schistosoma mansoni intermediate filament proteins 0.0028 0.0015 0.0012
Brugia malayi Neuronal calcium sensor family protein 1 0.0035 0.0054 0.0054
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0089 0.0089
Loa Loa (eye worm) calpain family protein 1 0.0255 0.1273 0.1273
Plasmodium falciparum serine repeat antigen 8 0.0041 0.0089 0.3049
Schistosoma mansoni chromobox protein 0.0068 0.0234 0.037
Plasmodium vivax unspecified product 0.0041 0.0089 0.152
Echinococcus granulosus integrin alpha 3 0.0086 0.0335 0.0423
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0041 0.0089 0.3049
Onchocerca volvulus 0.0028 0.0015 0.0072
Entamoeba histolytica calmodulin, putative 0.0035 0.0054 0.0956
Giardia lamblia Cathepsin B precursor 0.0373 0.1927 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0584 0.303
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0149 0.0183
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0086 0.0335 0.0335
Plasmodium falciparum centrin-4 0.0035 0.0054 0.1847
Trypanosoma cruzi calmodulin, putative 0.0029 0.002 0.0034
Echinococcus multilocularis calbindin 32 0.0029 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0089
Schistosoma mansoni centrin-related 0.0029 0.002 0.0022
Brugia malayi calcium-binding protein 0.0029 0.002 0.002
Trypanosoma brucei hypothetical protein 0.0039 0.0077 0.04
Trypanosoma cruzi cysteine proteinase, putative 0.0056 0.0171 0.0283
Trypanosoma cruzi I/6 autoantigen, putative 0.0029 0.002 0.0034
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Loa Loa (eye worm) integrin alpha pat-2 0.0179 0.0852 0.0852
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0039 0.0077 0.0128
Schistosoma mansoni calpain-7 (C02 family) 0.0134 0.06 0.0967
Loa Loa (eye worm) calpain D 0.0039 0.0077 0.0077
Loa Loa (eye worm) calmodulin-like protein 0.0029 0.002 0.002
Echinococcus granulosus calcium uptake protein 1 0.0029 0.002 0.0017
Toxoplasma gondii ribonuclease HI protein 0.0027 0.0007 0.0036
Giardia lamblia Cysteine protease 0.0041 0.0089 0.0426
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0109 0.0132
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0029 0.002 0.007
Leishmania major calcineurin B subunit, putative 0.0029 0.002 0.0106
Schistosoma mansoni integrin alpha-ps 0.0093 0.0376 0.0602
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0029 0.002 0.0017
Trypanosoma cruzi cysteine protease, putative 0.0056 0.0171 0.0283
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0085 0.0407
Echinococcus multilocularis plexin a4 0.007 0.0248 0.0311
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0052 0.0149 0.0741
Plasmodium falciparum serine repeat antigen 1 0.0041 0.0089 0.3049
Schistosoma mansoni hypothetical protein 0.007 0.0246 0.0389
Mycobacterium ulcerans hypothetical protein 0.0108 0.0456 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.0108 0.0456 0.0456
Brugia malayi intermediate filament protein 0.0028 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0089 0.0426
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0052 0.0149 0.0149
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0039 0.0077 0.0128
Onchocerca volvulus 0.0078 0.0291 0.2708
Mycobacterium ulcerans beta-lactamase 0.0108 0.0456 1
Leishmania major ribonuclease H1, putative 0.0027 0.0007 0.0036
Entamoeba histolytica cysteine proteinase 1, putative 0.0056 0.0171 0.4318
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0089 0.0133
Brugia malayi cathepsin F-like cysteine proteinase 0.0041 0.0089 0.0089
Trypanosoma brucei protein kinase, putative 0.0049 0.0133 0.0691
Loa Loa (eye worm) hypothetical protein 0.0233 0.1151 0.1151
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.067 0.067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Onchocerca volvulus 0.0063 0.0209 0.1926
Echinococcus granulosus calmodulin 0.0029 0.002 0.0017
Brugia malayi hypothetical protein 0.0292 0.1481 0.1481
Echinococcus granulosus EF hand domain containing family member A2 0.0029 0.002 0.0017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0089 0.0133
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0648 0.0826
Onchocerca volvulus 0.0078 0.0291 0.2708
Plasmodium vivax calpain, putative 0.0131 0.0584 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Echinococcus granulosus cathepsin b 0.1113 0.6032 0.7766
Leishmania major cathepsin L-like protease 0.0078 0.0291 0.151
Trichomonas vaginalis caltractin, putative 0.0035 0.0054 0.0243
Echinococcus multilocularis programmed cell death protein 0.0064 0.0215 0.0268
Trichomonas vaginalis calmodulin, putative 0.0029 0.002 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Loa Loa (eye worm) hypothetical protein 0.0062 0.0203 0.0203
Loa Loa (eye worm) ctsf protein 0.0078 0.0291 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0888 0.1436
Trypanosoma brucei unspecified product 0.0029 0.002 0.0102
Echinococcus multilocularis integrin alpha ps 0.0179 0.0852 0.109
Schistosoma mansoni ef hand domain family member A2 0.0029 0.002 0.0022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.0128
Entamoeba histolytica grainin 2 0.0035 0.0054 0.0956
Trichomonas vaginalis calcium binding protein, putative 0.0029 0.002 0.007
Giardia lamblia Hypothetical protein 0.0041 0.0089 0.0426
Brugia malayi beta-lactamase family protein 0.0108 0.0456 0.0456
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Loa Loa (eye worm) myosin regulatory light chain 1 0.0035 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0045 0.0109 0.0109
Trichomonas vaginalis caltractin, putative 0.0035 0.0054 0.0243
Toxoplasma gondii calmodulin CAM1 0.0029 0.002 0.0106
Mycobacterium leprae Probable lipase LipE 0.0108 0.0456 0.5
Trypanosoma brucei protein I/6 0.0029 0.002 0.0106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0089 0.0426
Leishmania major hypothetical protein, conserved 0.0029 0.002 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Schistosoma mansoni lamin 0.0028 0.0015 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0888 0.1136
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0456 0.0578
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0939 0.5066 0.6521
Giardia lamblia Hypothetical protein 0.0029 0.002 0.007
Onchocerca volvulus Cathepsin L homolog 0.0041 0.0089 0.0779
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0052 0.0149 0.5128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0089 0.0426
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0133 0.0691
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1113 0.6032 0.9818
Schistosoma mansoni chromobox protein 0.0068 0.0234 0.037
Trypanosoma brucei cysteine peptidase C (CPC) 0.0373 0.1927 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0584 0.0968
Giardia lamblia Encystation-specific protease 0.0041 0.0089 0.0426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0291 0.1479
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0133 0.0163
Loa Loa (eye worm) hypothetical protein 0.0307 0.1562 0.1562
Onchocerca volvulus 0.0216 0.1056 1
Onchocerca volvulus 0.0078 0.0291 0.2708
Trypanosoma brucei kinesin, putative 0.0091 0.0366 0.19
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0584 0.303
Schistosoma mansoni calpain-7 (C02 family) 0.0134 0.06 0.0967
Echinococcus multilocularis cathepsin L 0.0041 0.0089 0.0105
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0687 0.3671 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0039 0.0077 0.0128
Leishmania major cathepsin L-like protease 0.0078 0.0291 0.151
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0291 0.1479
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0051
Toxoplasma gondii preprocathepsin c precursor, putative 0.0041 0.0089 0.0461
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0039 0.0077 0.0365
Echinococcus multilocularis integrin alpha 3 0.0086 0.0335 0.0423
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0041 0.0089 0.0426
Trypanosoma brucei Calpain-like protein CALP1.3 0.0039 0.0077 0.04
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0456 0.2337
Echinococcus multilocularis centrin 2 0.0029 0.002 0.0017
Brugia malayi hypothetical protein 0.0233 0.1151 0.1151
Echinococcus multilocularis EF hand domain containing family member A2 0.0029 0.002 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0246 0.0246
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0584 0.0968
Loa Loa (eye worm) hypothetical protein 0.0108 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0063 0.0209 0.0209
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0291 0.0366
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0089 0.152
Plasmodium vivax vivapain-1 0.0056 0.0171 0.2924
Giardia lamblia Cathepsin B precursor 0.0041 0.0089 0.0426
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1113 0.6032 0.9818
Schistosoma mansoni cathepsin B (C01 family) 0.0041 0.0089 0.0133
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.002
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1151 0.1475
Schistosoma mansoni neuronal calcium sensor 0.0029 0.002 0.0022
Plasmodium falciparum serine repeat antigen 5 0.0041 0.0089 0.3049
Leishmania major hypothetical protein, conserved 0.0029 0.002 0.0106
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0291 0.7774
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0052 0.0149 0.0247
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0291 0.2708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0291 0.1479
Schistosoma mansoni integrin alpha-4 0.0766 0.4106 0.6681
Trichomonas vaginalis calcium binding protein, putative 0.0064 0.0215 0.1084
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.0128
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0051
Toxoplasma gondii ABC1 family protein 0.0108 0.0456 0.2365
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0089 0.0133
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Brugia malayi cathepsin L precursor 0.0041 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0093 0.0376 0.0376
Schistosoma mansoni calmodulin-related 0.0035 0.0054 0.0076
Echinococcus granulosus integrin alpha ps 0.0179 0.0852 0.109
Trichomonas vaginalis calcium binding proteins, putative 0.0029 0.002 0.007
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.067 0.0855
Echinococcus granulosus fibrillin 1 0.0062 0.0203 0.0253
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.0584 0.0968
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0291 0.1479
Plasmodium falciparum serine repeat antigen 2 0.0041 0.0089 0.3049
Entamoeba histolytica cysteine protease, putative 0.0041 0.0089 0.1962
Trichomonas vaginalis calpain, putative 0.0039 0.0077 0.0365
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0123 0.0123
Onchocerca volvulus 0.0048 0.0123 0.1103
Trypanosoma brucei calpain-like protein, putative 0.0131 0.0584 0.303
Giardia lamblia Cathepsin B precursor 0.0041 0.0089 0.0426
Loa Loa (eye worm) hypothetical protein 0.0255 0.1273 0.1273
Loa Loa (eye worm) hypothetical protein 0.0062 0.0203 0.0203
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0041 0.0089 0.0089
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0456 0.2365
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0376 0.1942 0.3153
Schistosoma mansoni myosin light chain 0.0035 0.0054 0.0076
Brugia malayi RNase H family protein 0.0027 0.0007 0.0007
Onchocerca volvulus 0.0078 0.0291 0.2708
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0041 0.0089 0.0426
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0007 0.0012
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.0128
Onchocerca volvulus 0.0078 0.0291 0.2708
Echinococcus multilocularis lamin dm0 0.0028 0.0015 0.001
Echinococcus multilocularis fk506 binding protein 0.0052 0.0149 0.0183
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0376 0.1942 0.3153
Brugia malayi RNase H family protein 0.0027 0.0007 0.0007
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0029 0.002 0.0034
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0425 0.0425
Trichomonas vaginalis calcineurin B subunit, putative 0.0029 0.002 0.007
Echinococcus granulosus EF hand domain containing family member A2 0.0029 0.002 0.0017
Loa Loa (eye worm) beta-lactamase 0.0108 0.0456 0.0456
Brugia malayi EF hand family protein 0.0029 0.002 0.002
Leishmania major calmodulin-like protein 0.0029 0.002 0.0106
Brugia malayi Cathepsin L-like precursor 0.0078 0.0291 0.0291
Schistosoma mansoni myosin regulatory light chain 0.0035 0.0054 0.0076
Schistosoma mansoni lamin 0.0028 0.0015 0.0012
Leishmania major fk506-binding protein 1-like protein 0.0052 0.0149 0.0775
Loa Loa (eye worm) hypothetical protein 0.0292 0.1481 0.1481
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0078 0.0291 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0291 0.1479
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0456 0.0756
Trypanosoma brucei calpain, putative 0.0039 0.0077 0.04
Leishmania major calmodulin-like protein 0.0029 0.002 0.0106
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0039 0.0077 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0089 0.0426
Leishmania major calpain protease-like protein 0.0039 0.0077 0.04
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0041 0.0089 0.0426
Entamoeba histolytica cysteine proteinase 2 0.0056 0.0171 0.4318
Giardia lamblia Cathepsin L precursor 0.0041 0.0089 0.0426
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Echinococcus multilocularis fibrillin 1 0.0062 0.0203 0.0253
Leishmania major cathepsin L-like protease 0.0078 0.0291 0.151
Entamoeba histolytica hypothetical protein 0.0035 0.0053 0.0924
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0888 0.1136
Trichomonas vaginalis centrin, putative 0.0029 0.002 0.007
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0376 0.1942 0.2494
Trypanosoma brucei centrin, putative 0.0029 0.002 0.0106
Loa Loa (eye worm) myosin Light Chain family member 0.0035 0.0054 0.0054
Echinococcus multilocularis hypothetical protein 0.0131 0.0584 0.0744
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0133 0.0133
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0052 0.0149 0.0183
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0078 0.0369
Trichomonas vaginalis calmodulin, putative 0.0029 0.002 0.007
Schistosoma mansoni immunophilin 0.0045 0.0109 0.0167
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1151 0.1475
Trypanosoma brucei mitochondrial calcium uptake 1 0.0029 0.002 0.0106
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0029 0.002 0.007
Trypanosoma cruzi centrin, putative 0.0064 0.0215 0.0357
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0456 0.0731
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0291 0.1479
Echinococcus multilocularis cathepsin b 0.1113 0.6032 0.7766
Echinococcus multilocularis EF hand domain containing family member A2 0.0029 0.002 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.002 0.007
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0035 0.0054 0.0446
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0133 0.0657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.2346 0.3015
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.0089 0.0147
Echinococcus granulosus cathepsin b 0.1113 0.6032 0.7766
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0089 0.0089
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0029 0.002 0.0102
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0035 0.0054 0.092
Brugia malayi Probable myosin regulatory light chain 0.0035 0.0054 0.0054
Entamoeba histolytica cysteine proteinase, putative 0.0063 0.0209 0.5418
Toxoplasma gondii EFHC1, putative 0.0029 0.002 0.0106
Loa Loa (eye worm) hypothetical protein 0.0108 0.0456 0.0456
Brugia malayi Cathepsin L-like precursor 0.0078 0.0291 0.0291
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0052 0.0149 0.0741
Brugia malayi Cathepsin L-like precursor 0.0063 0.0209 0.0209
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0109 0.0132
Schistosoma mansoni hypothetical protein 0.0688 0.3676 0.5979
Onchocerca volvulus Cathepsin F homolog 0.0078 0.0291 0.2708
Echinococcus multilocularis calpain 0.0131 0.0584 0.0744
Loa Loa (eye worm) hypothetical protein 0.0078 0.0291 0.0291
Loa Loa (eye worm) cathepsin B 0.0373 0.1927 0.1927
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0098 0.0117
Loa Loa (eye worm) hypothetical protein 0.0216 0.1056 0.1056
Onchocerca volvulus 0.0078 0.0291 0.2708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.0209 0.1052
Giardia lamblia Cysteine protease 0.0041 0.0089 0.0426
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.002 0.0102
Brugia malayi EGF-like domain containing protein 0.0062 0.0203 0.0203
Giardia lamblia Calmodulin 0.0035 0.0054 0.0243
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0131 0.0584 0.0968
Leishmania major cathepsin L-like protease 0.0078 0.0291 0.151
Echinococcus granulosus neurocalcin 0.0029 0.002 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.0584 0.0968
Leishmania major phospholipase c-like protein 0.0029 0.002 0.0106
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0133 0.0163
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Echinococcus granulosus neuronal calcium sensor 0.0029 0.002 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0089 0.0426
Brugia malayi cathepsin L-like precursor 0.0063 0.0209 0.0209
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0373 0.1927 0.3194
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0089 0.0089
Leishmania major cathepsin L-like protease 0.0078 0.0291 0.151
Brugia malayi calpain 5 0.0091 0.0366 0.0366
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0041 0.0089 0.152
Schistosoma mansoni mitochondrial solute carrier 0.0029 0.002 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0133 0.0206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0425 0.0425
Echinococcus granulosus EF HAND 1 calcium binding site 0.0029 0.002 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0584 0.303
Leishmania major protein kinase, putative 0.003 0.0023 0.0119
Brugia malayi Heterochromatin protein 1 0.0068 0.0234 0.0234
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0085 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Onchocerca volvulus 0.0029 0.002 0.0128
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0078 0.2676
Loa Loa (eye worm) hypothetical protein 0.003 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0086 0.0335 0.0335
Plasmodium falciparum serine repeat antigen 3 0.0041 0.0089 0.3049
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0171 0.4318
Giardia lamblia Cathepsin L-like protease 0.0041 0.0089 0.0426
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0133 0.0657
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0133 0.0163
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.003 0.0023 0.0119
Trypanosoma brucei calpain-like protein, putative 0.0131 0.0584 0.303
Loa Loa (eye worm) acetyltransferase 0.0146 0.067 0.067
Trichomonas vaginalis calmodulin, putative 0.0029 0.002 0.007
Trichomonas vaginalis calcium binding protein, putative 0.0029 0.002 0.007
Echinococcus multilocularis cathepsin b 0.1113 0.6032 0.7766
Brugia malayi Plexin repeat family protein 0.0059 0.0188 0.0188
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0292 0.1481 0.1481
Plasmodium falciparum serine repeat antigen 9 0.0041 0.0089 0.3049
Toxoplasma gondii centrin family protein 0.0035 0.0054 0.0279
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.2346 0.3015
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0052 0.0149 0.0149
Brugia malayi MAP kinase sur-1 0.0049 0.0133 0.0133
Schistosoma mansoni calmodulin 0.0029 0.002 0.0022
Echinococcus granulosus cysteine protease 0.0056 0.0171 0.0211
Leishmania major cathepsin L-like protease 0.0078 0.0291 0.151
Brugia malayi Myosin regulatory light chain 1 0.0035 0.0054 0.0054
Brugia malayi beta-lactamase 0.0108 0.0456 0.0456
Schistosoma mansoni immunophilin 0.0052 0.0149 0.0232
Trypanosoma brucei centrin-3 0.0064 0.0215 0.1116
Leishmania major peptidylprolyl isomerase-like protein 0.0052 0.0149 0.0775
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0171 0.4318
Onchocerca volvulus 0.0108 0.0456 0.4279
Brugia malayi chromobox protein homolog 3 0.0038 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0035 0.0053 0.0924
Trypanosoma brucei calpain, putative 0.0039 0.0077 0.04
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Trypanosoma brucei calmodulin, putative 0.0029 0.002 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0052 0.0149 1
Toxoplasma gondii cathepsin CPC1 0.0041 0.0089 0.0461
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0038 0.0038
Echinococcus multilocularis calumenin 0.0029 0.002 0.0017
Schistosoma mansoni calpain (C02 family) 0.0131 0.0584 0.094
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.003 0.0023 0.0393
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0089 0.0133
Echinococcus multilocularis cysteine protease 0.0078 0.0291 0.0366
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0089 0.0133
Loa Loa (eye worm) hypothetical protein 0.0063 0.0209 0.0209
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0171 0.0171
Trichomonas vaginalis calmodulin, putative 0.0029 0.002 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Toxoplasma gondii hypothetical protein 0.0062 0.0203 0.1054
Giardia lamblia Cathepsin L precursor 0.0041 0.0089 0.0426
Leishmania major i/6 autoantigen-like protein 0.0029 0.002 0.0106
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Onchocerca volvulus 0.003 0.0024 0.016
Schistosoma mansoni integrin beta subunit 0.1133 0.6143 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0584 0.0968
Loa Loa (eye worm) FKBP5 protein 0.0052 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.0365
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0456 0.7806
Loa Loa (eye worm) hypothetical protein 0.0347 0.178 0.178
Echinococcus granulosus fibrillin 2 0.0062 0.0203 0.0253
Echinococcus multilocularis calpain 7 (C02 family) 0.0131 0.0584 0.0744
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0029 0.002 0.0106
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Echinococcus multilocularis programmed cell death protein 0.0064 0.0215 0.0268
Echinococcus granulosus cathepsin L cysteine proteinase 0.0078 0.0291 0.0366
Echinococcus multilocularis integrin alpha ps 0.0179 0.0852 0.109
Onchocerca volvulus 0.0035 0.0054 0.0446
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0149 0.0247
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0052 0.0149 0.0247
Plasmodium falciparum cysteine proteinase falcipain 3 0.0078 0.0291 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0089 0.0426
Echinococcus granulosus plexin a4 0.007 0.0248 0.0311
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0089 0.0133
Toxoplasma gondii EF hand domain-containing protein 0.0029 0.002 0.0106
Trypanosoma cruzi centrin-3 0.0064 0.0215 0.0357
Echinococcus multilocularis musashi 0.0028 0.0015 0.001
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0078 0.0291 1
Brugia malayi RNase H family protein 0.0027 0.0007 0.0007
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0089 0.0089
Trichomonas vaginalis myosin light chain 1, putative 0.0029 0.002 0.007
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0041 0.0089 0.0426
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.0888 0.0888
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0089 0.0089
Entamoeba histolytica grainin 2 0.0064 0.0215 0.5591
Schistosoma mansoni plexin 0.0059 0.0188 0.0295
Loa Loa (eye worm) fibroinase 0.0078 0.0291 0.0291
Echinococcus multilocularis cathepsin L 0.0056 0.0171 0.0211
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0291 0.1479
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0291 0.0482
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0041 0.0089 0.0133
Trichomonas vaginalis centrin, putative 0.0029 0.002 0.007
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0089 0.152
Plasmodium falciparum serine repeat antigen 7 0.0041 0.0089 0.3049
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0456 0.0756
Brugia malayi EF hand family protein 0.0029 0.002 0.002
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0149 0.0183
Schistosoma mansoni rab 0.0029 0.002 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0089 0.0426
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Trypanosoma brucei calpain-like protein, putative 0.0131 0.0584 0.303
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0054 0.0089
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0347 0.178 0.289
Schistosoma mansoni integrin alpha-ps 0.0179 0.0852 0.1377
Echinococcus granulosus calcyphosin protein 0.0035 0.0054 0.006
Schistosoma mansoni calpain C (C02 family) 0.0131 0.0584 0.094
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0888 0.1136
Trichomonas vaginalis calmodulin, putative 0.0035 0.0054 0.0243
Schistosoma mansoni neuronal calcium sensor 0.0029 0.002 0.0022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0373 0.1927 0.3128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0291 0.0482
Schistosoma mansoni hypothetical protein 0.0029 0.002 0.0022
Entamoeba histolytica hypothetical protein 0.0041 0.0089 0.1962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0069 0.0593
Trypanosoma brucei RNA helicase, putative 0.01 0.0414 0.2146
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0131 0.0584 0.303
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0004
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0039 0.0077 0.04
Plasmodium vivax hypothetical protein, conserved 0.0029 0.002 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0089 0.0426
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0133 0.0221
Brugia malayi calpain 7 0.0131 0.0584 0.0584
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0373 0.1927 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1113 0.6032 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0456 0.2337
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0456 0.2337
Schistosoma mansoni hypothetical protein 0.0035 0.0051 0.0071
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0035 0.0054 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0052 0.0149 0.37
Trichomonas vaginalis kakapo, putative 0.0035 0.0054 0.0243
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0056 0.0171 0.0267
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0291 0.0366
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0029 0.002 0.0034
Echinococcus multilocularis Calcium binding protein 0.0035 0.0054 0.006
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0133 0.0163
Loa Loa (eye worm) hypothetical protein 0.0035 0.0054 0.0054
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0015 0.0015
Leishmania major kinesin, putative 0.0091 0.0366 0.19
Schistosoma mansoni cathepsin S (C01 family) 0.0041 0.0089 0.0133
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0039 0.0077 0.0365
Brugia malayi Cathepsin L-like precursor 0.0078 0.0291 0.0291
Echinococcus granulosus chromobox protein 1 0.0068 0.0234 0.0292
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.0128
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0062 0.0203 0.1021
Echinococcus multilocularis integrin beta 2 0.1426 0.7765 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0089 0.0426
Loa Loa (eye worm) integrin beta-2 0.1829 1 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0039 0.0077 0.0365
Trypanosoma brucei ribonuclease H1 0.0027 0.0007 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0291 0.1479
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0291 0.0366
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0456 0.0578
Toxoplasma gondii calmodulin CAM2 0.0035 0.0054 0.0279
Trichomonas vaginalis calcium binding protein, putative 0.0029 0.002 0.007
Giardia lamblia Tenascin precursor 0.0062 0.0203 0.1021
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0456 1
Echinococcus multilocularis lamin 0.0028 0.0015 0.001
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0078 0.0291 0.0291
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0089 0.0426
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0052 0.0149 0.0149
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0089 0.0426
Leishmania major hypothetical protein, conserved 0.0108 0.0456 0.2365
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0069
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0029 0.002 0.0034
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0053 0.0059
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0039 0.0077 0.0365
Loa Loa (eye worm) hypothetical protein 0.0035 0.0054 0.0054
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.0128
Echinococcus multilocularis geminin 0.0688 0.3676 0.473
Brugia malayi cathepsin L-like cysteine proteinase 0.0041 0.0089 0.0089
Onchocerca volvulus 0.0108 0.0456 0.4279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Schistosoma mansoni centrin 0.0029 0.002 0.0022
Trypanosoma brucei calmodulin, putative 0.0029 0.002 0.0106
Giardia lamblia Tenascin-X 0.0062 0.0203 0.1021
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0089 0.0426
Trichomonas vaginalis calmodulin, putative 0.0029 0.002 0.007
Echinococcus multilocularis calpain A 0.0376 0.1942 0.2494
Leishmania major centrin, putative,caltractin, putative 0.0029 0.002 0.0106
Echinococcus multilocularis cysteine protease 0.0078 0.0291 0.0366
Echinococcus granulosus integrin alpha ps 0.0086 0.0335 0.0423
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0234 0.0234
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0098 0.0473
Schistosoma mansoni cathepsin C 0.0041 0.0089 0.0133
Echinococcus granulosus geminin 0.0688 0.3676 0.473
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.002 0.0102
Entamoeba histolytica protein kinase, putative 0.0092 0.0368 1
Brugia malayi Calmodulin-like protein 0.0029 0.002 0.002
Echinococcus granulosus calpain 5 0.0131 0.0584 0.0744
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Echinococcus multilocularis integrin alpha ps 0.0086 0.0335 0.0423
Trypanosoma cruzi I/6 autoantigen, putative 0.0029 0.002 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Trichomonas vaginalis calmodulin, putative 0.0064 0.0215 0.1084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0089 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0291 0.1479
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0133 0.0657
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0015 0.0015
Brugia malayi plexin A 0.007 0.0248 0.0248
Echinococcus granulosus calpain 0.0131 0.0584 0.0744
Loa Loa (eye worm) cysteine protease 0.0078 0.0291 0.0291
Echinococcus multilocularis chromobox protein 1 0.0068 0.0234 0.0292
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0584 0.303
Toxoplasma gondii EF hand domain-containing protein 0.0035 0.0054 0.0279
Loa Loa (eye worm) hypothetical protein 0.0035 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0089 0.0426
Giardia lamblia Cathepsin L precursor 0.0041 0.0089 0.0426
Mycobacterium ulcerans lipase LipD 0.0108 0.0456 1
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0291 0.0482
Giardia lamblia Cathepsin L precursor 0.0041 0.0089 0.0426
Echinococcus granulosus GPCR family 2 0.0032 0.0038 0.004
Giardia lamblia Cathepsin B precursor 0.0373 0.1927 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0089 0.0089
Leishmania major calmodulin, putative 0.0029 0.002 0.0106
Trypanosoma cruzi caltractin, putative 0.0029 0.002 0.0034
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0041 0.0089 0.1962
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0291 0.1479
Trichomonas vaginalis hypothetical protein 0.0062 0.0203 0.1021
Entamoeba histolytica calpain family cysteine protease, putative 0.0039 0.0077 0.1625
Plasmodium vivax centrin-1, putative 0.0029 0.002 0.035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0888 0.1436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0171 0.0853
Trichomonas vaginalis esterase, putative 0.0108 0.0456 0.2337
Giardia lamblia Neurogenic locus Notch protein precursor 0.0062 0.0203 0.1021
Trypanosoma brucei cysteine peptidase, putative 0.0039 0.0077 0.04
Trypanosoma brucei calpain-like protein, putative 0.0131 0.0584 0.303
Trypanosoma cruzi centrin, putative 0.0064 0.0215 0.0357
Trypanosoma cruzi calmodulin, putative 0.0029 0.002 0.0034
Trichomonas vaginalis calpain, putative 0.0039 0.0077 0.0365
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0015 0.0015
Onchocerca volvulus 0.0078 0.0291 0.2708
Brugia malayi cathepsin B-like cysteine proteinase 0.1113 0.6032 0.6032
Leishmania major calmodulin, putative 0.0029 0.002 0.0106
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0456 0.2337
Giardia lamblia High cysteine protein 0.0062 0.0203 0.1021
Schistosoma mansoni cathepsin F (C01 family) 0.0063 0.0209 0.0329
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0425 0.0425
Brugia malayi calpain 5 0.0039 0.0077 0.0077
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0052 0.0149 0.2556
Leishmania major programmed cell death 6 protein-like protein 0.0029 0.002 0.0106
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0089 0.152
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1113 0.6032 0.9818
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.0128
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.004
Trypanosoma cruzi conserved protein 0.0039 0.0077 0.0128
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0291 0.2708
Trypanosoma cruzi kinesin, putative 0.0091 0.0366 0.0607
Echinococcus granulosus adam 0.0062 0.0203 0.0253
Toxoplasma gondii cathepsin CPL 0.0078 0.0291 0.151
Entamoeba histolytica hypothetical protein 0.0035 0.0053 0.0924
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0086 0.0335 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Giardia lamblia hypothetical protein 0.0062 0.0203 0.1021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0039 0.0077 0.0128
Onchocerca volvulus 0.0029 0.002 0.0128
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.0888 0.0888
Giardia lamblia Cathepsin B precursor 0.0041 0.0089 0.0426
Plasmodium vivax vivapain-3 0.0056 0.0171 0.2924
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0291 0.0291
Plasmodium vivax vivapain-2 0.0078 0.0291 0.4984
Brugia malayi Kelch motif family protein 0.0292 0.1481 0.1481
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0098 0.0473
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0035 0.0054 0.0243
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0171 0.4318
Echinococcus multilocularis Myosin regulatory light chain 0.0035 0.0054 0.006
Trichomonas vaginalis calcineurin B subunit, putative 0.0029 0.002 0.007
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0291 0.0482
Echinococcus granulosus Myosin regulatory light chain 0.0035 0.0054 0.006
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0052 0.0149 0.37
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0133 0.0691
Entamoeba histolytica cysteine protease, putative 0.0041 0.0089 0.1962
Echinococcus multilocularis adam 0.0062 0.0203 0.0253
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0078 0.165
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0041 0.0089 0.3049
Schistosoma mansoni immunophilin 0.0052 0.0149 0.0232
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0038 0.0038
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0376 0.1942 0.2494
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0039 0.0077 0.04
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0456 0.0456
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0039 0.0077 0.0128
Giardia lamblia High cysteine protein 0.0062 0.0203 0.1021
Brugia malayi Integrin alpha pat-2 precursor 0.0179 0.0852 0.0852
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0171 0.0283
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1113 0.6032 0.9818
Echinococcus granulosus chromobox protein 1 0.0068 0.0234 0.0292
Trypanosoma cruzi cysteine proteinase, putative 0.0056 0.0171 0.0283
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.0128
Echinococcus multilocularis programmed cell death protein 6 0.0035 0.0054 0.006
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0029 0.002 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0041 0.0089 0.0426
Giardia lamblia Cathepsin L-like protease 0.0041 0.0089 0.0426
Brugia malayi Cathepsin L-like precursor 0.0063 0.0209 0.0209
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0039 0.0077 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0171 0.0853
Schistosoma mansoni hypothetical protein 0.0039 0.0077 0.0114
Toxoplasma gondii cathepsin CPC2 0.0041 0.0089 0.0461
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0052 0.0149 0.0741
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0234 0.1181
Entamoeba histolytica cysteine protease, putative 0.0041 0.0089 0.1962
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Trichomonas vaginalis calpain, putative 0.0039 0.0077 0.0365
Echinococcus multilocularis neuronal calcium sensor 0.0029 0.002 0.0017
Giardia lamblia Neurogenic locus notch-like protein 0.0062 0.0203 0.1021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.0584 0.0968
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Plasmodium falciparum serine repeat antigen 6 0.0041 0.0089 0.3049
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0098 0.0507
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0029 0.002 0.0022
Trypanosoma brucei Calpain-like protein 1.2 0.0039 0.0077 0.04
Brugia malayi EGF-like domain containing protein 0.0062 0.0203 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.0209 0.1052
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0133 0.0221
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0133 0.0221
Onchocerca volvulus 0.0041 0.0089 0.0779
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.002
Giardia lamblia Cysteine protease 0.0041 0.0089 0.0426
Plasmodium falciparum centrin-1 0.0029 0.002 0.0703
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0041 0.0089 0.0133
Schistosoma mansoni hypothetical protein 0.0688 0.3676 0.5979
Brugia malayi Cathepsin L-like cysteine proteinase 0.0063 0.0209 0.0209
Leishmania major hypothetical protein, unknown function 0.0039 0.0077 0.04
Brugia malayi calpain D 0.0039 0.0077 0.0077
Trypanosoma brucei I/6 autoantigen 0.0029 0.002 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Echinococcus granulosus cathepsin l cysteine peptidase 0.0078 0.0291 0.0366
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0039 0.0077 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Loa Loa (eye worm) hypothetical protein 0.0102 0.0425 0.0425
Toxoplasma gondii hypothetical protein 0.0039 0.0077 0.04
Plasmodium falciparum serine repeat antigen 4 0.0041 0.0089 0.3049
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0041 0.0089 0.0089
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0041 0.0089 0.152
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.004 0.008 0.0415
Leishmania major cathepsin L-like protease 0.0078 0.0291 0.151
Leishmania major centrin, putative 0.0029 0.002 0.0106
Loa Loa (eye worm) hypothetical protein 0.0062 0.0203 0.0203
Trichomonas vaginalis centrin, putative 0.0035 0.0054 0.0243
Schistosoma mansoni reticulocalbin 0.0029 0.002 0.0022
Brugia malayi RasGEF domain containing protein 0.0035 0.0054 0.0054
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Toxoplasma gondii centrin, putative 0.0029 0.002 0.0106
Brugia malayi fibroinase precursor 0.0041 0.0089 0.0089
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0054 0.0243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0291 0.1479
Trypanosoma cruzi kinesin, putative 0.0091 0.0366 0.0607
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0053 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0324
Trichomonas vaginalis calmodulin, putative 0.0029 0.002 0.007
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0039 0.0077 0.04
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0056 0.0171 0.0283
Schistosoma mansoni survival motor neuron protein 0.0048 0.0123 0.0188
Echinococcus granulosus lamin dm0 0.0028 0.0015 0.001
Trypanosoma brucei Component of motile flagella 41 0.0029 0.002 0.0106
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0089 0.0133
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Loa Loa (eye worm) hypothetical protein 0.007 0.0246 0.0246
Echinococcus granulosus cathepsin l1 0.0078 0.0291 0.0366
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0456 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0291 0.0463
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0029 0.002 0.0017
Schistosoma mansoni calmodulin related calcium binding protein 0.0029 0.002 0.0022
Toxoplasma gondii troponin c, isotype gamma, putative 0.0029 0.002 0.0106
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0051
Trichomonas vaginalis immunophilin, putative 0.0052 0.0149 0.0741
Echinococcus granulosus integrin beta 2 0.1426 0.7765 1
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.002 0.0102
Trypanosoma cruzi calmodulin, putative 0.0029 0.002 0.0034
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0133 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.002 0.007
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Echinococcus multilocularis neurocalcin 0.0029 0.002 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0171 0.0886
Echinococcus granulosus calpain A 0.0131 0.0584 0.0744
Echinococcus granulosus programmed cell death protein 0.0064 0.0215 0.0268
Echinococcus granulosus cathepsin L 0.0041 0.0089 0.0105
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.0584 0.0968
Brugia malayi calpain family protein 1 0.0347 0.178 0.178
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.2346 0.3015
Echinococcus multilocularis calmodulin 0.0029 0.002 0.0017
Entamoeba histolytica cysteine protease, putative 0.0041 0.0089 0.1962
Entamoeba histolytica cysteine protease, putative 0.0078 0.0291 0.7774
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0029 0.002 0.0017
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0089 0.0426
Brugia malayi calpain family protein 1 0.0347 0.178 0.178
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0041 0.0089 0.152
Giardia lamblia Cathepsin L precursor 0.0041 0.0089 0.0426
Onchocerca volvulus 0.0062 0.0203 0.187
Leishmania major cysteine peptidase A (CPA) 0.0078 0.0291 0.151
Schistosoma mansoni Mername-AA248 (C02 family) 0.0131 0.0584 0.094
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.04
Loa Loa (eye worm) hypothetical protein 0.0108 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0108 0.0456 0.0456
Giardia lamblia Cathepsin B precursor 0.0041 0.0089 0.0426
Schistosoma mansoni hypothetical protein 0.0048 0.0123 0.0188
Echinococcus granulosus intermediate filament protein 0.0028 0.0015 0.001
Trypanosoma brucei caltractin, putative 0.0064 0.0215 0.1116
Trichomonas vaginalis centrin, putative 0.0035 0.0054 0.0243
Loa Loa (eye worm) calpain 0.0131 0.0584 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0089 0.0426
Schistosoma mansoni hypothetical protein 0.0035 0.0053 0.0074
Loa Loa (eye worm) hypothetical protein 0.0093 0.0376 0.0376
Echinococcus granulosus calumenin 0.0029 0.002 0.0017
Plasmodium vivax unspecified product 0.0056 0.0171 0.2924
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0039 0.0077 0.0128
Toxoplasma gondii calmodulin, putative 0.0035 0.0054 0.0279
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0039 0.0077 0.0128
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0041 0.0089 0.152
Schistosoma mansoni neuronal calcium sensor 0.0029 0.002 0.0022
Schistosoma mansoni hypothetical protein 0.01 0.0414 0.0663
Brugia malayi EGF-like domain containing protein 0.0062 0.0203 0.0203
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0456 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0091 0.0366 0.9929
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Brugia malayi Cathepsin L-like precursor 0.0078 0.0291 0.0291
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0133 0.0657
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0291 0.7774
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0041 0.0089 0.152
Echinococcus granulosus lamin 0.0028 0.0015 0.001
Entamoeba histolytica cysteine protease, putative 0.0056 0.0171 0.4318
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0052 0.0149 0.0741
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.003 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0089
Giardia lamblia Cysteine protease 0.0041 0.0089 0.0426
Echinococcus granulosus cathepsin l1 0.0063 0.0209 0.026
Brugia malayi programmed cell death protein 6 0.0029 0.002 0.002
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0098 0.0507
Schistosoma mansoni myosin regulatory light chain 0.0035 0.0054 0.0076
Giardia lamblia Cathepsin L precursor 0.0041 0.0089 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0456 0.0731
Giardia lamblia Programmed cell death protein-like protein 0.0035 0.0054 0.0243
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0456 0.2337
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0038
Echinococcus granulosus calpain 7 C02 family 0.0131 0.0584 0.0744
Toxoplasma gondii centrin 0.0029 0.002 0.0106
Schistosoma mansoni calpain-2 (C02 family) 0.0039 0.0077 0.0114
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0041 0.0089 0.3049
Echinococcus multilocularis GPCR, family 2 0.0032 0.0038 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0373 0.1927 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Loa Loa (eye worm) hypothetical protein 0.0108 0.0456 0.0456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Echinococcus multilocularis calpain 5 0.0131 0.0584 0.0744
Loa Loa (eye worm) hypothetical protein 0.1113 0.6032 0.6032
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0133 0.0691
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0291 0.1479
Echinococcus granulosus neuropeptide s receptor 0.0448 0.2346 0.3015
Giardia lamblia Tenascin-37 0.0062 0.0203 0.1021
Loa Loa (eye worm) hypothetical protein 0.0062 0.0203 0.0203
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.002 0.0106
Loa Loa (eye worm) programmed cell death protein 6 0.0029 0.002 0.002
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0041 0.0089 0.152
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0171 0.4318
Brugia malayi beta-lactamase family protein 0.0108 0.0456 0.0456
Entamoeba histolytica hypothetical protein 0.0035 0.0053 0.0924
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0171 0.0886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0888 0.1436
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0085 0.0745
Trichomonas vaginalis calmodulin, putative 0.0029 0.002 0.007
Echinococcus multilocularis calcyphosin protein 0.0035 0.0054 0.006
Loa Loa (eye worm) EF hand family protein 0.0029 0.002 0.002
Plasmodium falciparum cysteine proteinase falcipain 1 0.0056 0.0171 0.5867
Echinococcus multilocularis protein jagged 2 0.0062 0.0203 0.0253
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0056 0.0171 0.0267
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0041 0.0089 0.152
Trichomonas vaginalis hypothetical protein 0.0039 0.0077 0.0365
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0149 0.0247
Echinococcus multilocularis calcium uptake protein 1 0.0029 0.002 0.0017
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0133 0.0691
Toxoplasma gondii cathepsin B 0.0373 0.1927 1
Leishmania major hypothetical protein, conserved 0.0039 0.0077 0.04
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0039 0.0077 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0089 0.0426
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0089
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.004
Echinococcus granulosus Calcium binding protein 0.0035 0.0054 0.006
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0052 0.0149 0.0775
Onchocerca volvulus 0.0059 0.0188 0.1725
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0077
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0027 0.0007 0.5
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0041 0.0089 0.152
Entamoeba histolytica cysteine protease, putative 0.0041 0.0089 0.1962
Schistosoma mansoni reticulocalbin 0.0029 0.002 0.0022
Brugia malayi EGF-like domain containing protein 0.0062 0.0203 0.0203
Echinococcus multilocularis fibrillin 2 0.0062 0.0203 0.0253
Onchocerca volvulus 0.0108 0.0456 0.4279
Trypanosoma brucei Calpain-like protein 1.1 0.0039 0.0077 0.04
Trichomonas vaginalis calmodulin, putative 0.0029 0.002 0.007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0133 0.0657
Onchocerca volvulus 0.0029 0.002 0.0128
Toxoplasma gondii calcium binding protein precursor, putative 0.0035 0.0054 0.0279
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0041 0.0089 0.1962
Trypanosoma brucei centrin, putative 0.0029 0.002 0.0106
Onchocerca volvulus 0.0028 0.0015 0.0072
Trichomonas vaginalis centrin, putative 0.0035 0.0054 0.0243
Trypanosoma brucei Calpain-like protein 2 0.0039 0.0077 0.04
Leishmania major centrin, putative 0.0029 0.002 0.0106
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0029 0.002 0.0022
Trypanosoma brucei antigen, putative 0.0131 0.0584 0.303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0089
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0234 0.1181
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0149 0.0775
Loa Loa (eye worm) plexin A 0.007 0.0248 0.0248
Loa Loa (eye worm) calpain family protein 1 0.0347 0.178 0.178
Plasmodium falciparum calpain 0.0039 0.0077 0.2647
Echinococcus multilocularis calmodulin 0.0029 0.002 0.0017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0291 0.0366
Loa Loa (eye worm) hypothetical protein 0.0063 0.0209 0.0209
Brugia malayi Cathepsin L-like precursor 0.0078 0.0291 0.0291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Toxoplasma gondii calcium-dependent protein kinase 0.003 0.0023 0.0119
Onchocerca volvulus 0.0035 0.0054 0.0446
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0171 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0291 0.151
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0098 0.1674
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0324
Schistosoma mansoni plexin 0.0035 0.0051 0.0071
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0291 0.0463
Echinococcus granulosus calbindin 32 0.0029 0.002 0.0017
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0052 0.0149 0.0232

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibitory activity against HIV-1 reverse transcriptase (HIV-RT) ChEMBL. 7689109
IC50 (binding) > 10 uM Inhibitory activity against HIV-1 reverse transcriptase (HIV-RT) ChEMBL. 7689109
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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