Detailed information for compound 1402310

Basic information

Technical information
  • TDR Targets ID: 1402310
  • Name: 2-amino-6-(5-methylfuran-2-yl)-4-phenylpyridi ne-3-carbonitrile
  • MW: 275.305 | Formula: C17H13N3O
  • H donors: 1 H acceptors: 2 LogP: 3.56 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(N)nc(cc1c1ccccc1)c1ccc(o1)C
  • InChi: 1S/C17H13N3O/c1-11-7-8-16(21-11)15-9-13(12-5-3-2-4-6-12)14(10-18)17(19)20-15/h2-9H,1H3,(H2,19,20)
  • InChiKey: HEHSZSBMWMFSPW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-amino-6-(5-methyl-2-furyl)-4-phenyl-pyridine-3-carbonitrile
  • 2-amino-6-(5-methyl-2-furyl)-4-phenyl-3-pyridinecarbonitrile
  • 2-amino-6-(5-methyl-2-furyl)-4-phenyl-nicotinonitrile
  • 2-amino-6-(5-methylfuran-2-yl)-4-phenyl-pyridine-3-carbonitrile
  • 2-Amino-6-(5-methyl-furan-2-yl)-4-phenyl-nicotinonitrile
  • MLS000030913
  • ST5309459
  • ASN 00758919
  • SMR000001527

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus pyruvate kinase 0.0021 0.0092 0.0109
Brugia malayi Doublecortin family protein 0.0071 0.0617 0.1875
Echinococcus granulosus intermediate filament protein 0.0033 0.0215 0.0254
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0178 0.0542
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0088 0.0267
Brugia malayi Pre-SET motif family protein 0.0036 0.0251 0.0764
Loa Loa (eye worm) hypothetical protein 0.0071 0.0614 0.1865
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1912 0.1912
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0238 0.2336 0.2816
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0366 0.0417
Plasmodium vivax vivapain-2 0.002 0.0088 0.0193
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.033 0.2974
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0074 0.0643 0.0773
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0215 0.0253
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0536 0.0536
Plasmodium vivax metacaspase 1, putative 0.0021 0.01 0.0227
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0675 0.6305
Leishmania major pyruvate kinase 0.004 0.0295 0.2637
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0142 0.0406
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0019 0.0057
Loa Loa (eye worm) hypothetical protein 0.004 0.0295 0.0897
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0022 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0848 0.7974
Loa Loa (eye worm) hypothetical protein 0.0074 0.0646 0.1963
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2472 0.4965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0021 0.01 0.01
Onchocerca volvulus 0.0074 0.0646 0.2227
Onchocerca volvulus 0.0071 0.0617 0.2124
Brugia malayi beta-lactamase family protein 0.0074 0.0646 0.1963
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0045 0.0221
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0366 0.0704
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.1957 0.5948
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0047 0.024
Mycobacterium tuberculosis Conserved protein 0.0074 0.0646 0.0777
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0088 0.0248
Giardia lamblia Pyruvate kinase 0.004 0.0295 0.059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0108 0.0128
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.4781 0.5765
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1912 0.5811
Echinococcus granulosus dna polymerase eta 0.0023 0.012 0.0141
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0092 0.0262
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.01 0.075
Echinococcus multilocularis muscleblind protein 1 0.018 0.1743 0.1743
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0088 0.014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0243 0.0267
Echinococcus multilocularis Polycystic kidney disease protein 0.0071 0.0617 0.0617
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0646 0.0777
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0254 0.2502 0.4868
Giardia lamblia Fructose-bisphosphate aldolase 0.0492 0.4961 1
Brugia malayi nuclear receptor NHR-88 0.0022 0.0108 0.0329
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.0393 0.0463
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0254 0.2502 0.2947
Loa Loa (eye worm) hypothetical protein 0.018 0.1743 0.5297
Trypanosoma brucei unspecified product 0.0016 0.0045 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1058 0.1246
Schistosoma mansoni pyruvate kinase 0.004 0.0295 0.0347
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.012 0.0943
Brugia malayi glutathione reductase 0.0094 0.0848 0.2577
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0092 0.0206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0492 0.4961 1
Brugia malayi RNA binding protein 0.0065 0.0546 0.1658
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0646 0.0755
Loa Loa (eye worm) hypothetical protein 0.0053 0.0431 0.1309
Echinococcus multilocularis RUN 0.0071 0.0617 0.0617
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0546 0.0642
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0254 0.2502 1
Loa Loa (eye worm) RNA binding protein 0.0065 0.0546 0.1658
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0108 0.0329
Loa Loa (eye worm) hypothetical protein 0.0074 0.0646 0.1963
Echinococcus granulosus lamin dm0 0.0033 0.0215 0.0254
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0106
Echinococcus granulosus pyruvate kinase 0.004 0.0295 0.0347
Mycobacterium tuberculosis Probable oxidoreductase 0.0238 0.2336 0.2816
Loa Loa (eye worm) hypothetical protein 0.0047 0.0366 0.1113
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0505 0.466
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0088 0.0088
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0215 0.186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0215 0.186
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.033 0.2974
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0492 0.4961 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1058 1
Mycobacterium ulcerans hypothetical protein 0.0047 0.0366 0.0417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0215 0.186
Trypanosoma brucei unspecified product 0.0016 0.0045 0.0221
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0646 0.0777
Echinococcus multilocularis pyruvate kinase 0.0021 0.0092 0.0092
Leishmania major DNA polymerase eta, putative 0.0023 0.012 0.0943
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0848 0.102
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0646 0.0777
Loa Loa (eye worm) hypothetical protein 0.0201 0.1957 0.5948
Schistosoma mansoni hypothetical protein 0.0037 0.0257 0.0303
Schistosoma mansoni rab6-interacting 0.0071 0.0617 0.0727
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0254 0.2502 0.7256
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0546 0.1658
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0108 0.0128
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0166 0.1599 0.1906
Brugia malayi hypothetical protein 0.0071 0.0617 0.1875
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0243 0.07
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0067
Trypanosoma brucei Metacaspase-4 0.0021 0.01 0.075
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0243 0.0291
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0047 0.024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0108 0.0329
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0171 0.0489
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0646 0.0761
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0366 0.0417
Echinococcus multilocularis pyruvate kinase 0.0032 0.0207 0.0207
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.128 0.3889
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0171 0.1435
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.2472 0.7513
Loa Loa (eye worm) ctsf protein 0.002 0.0088 0.0267
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.012 0.0363
Onchocerca volvulus 0.0036 0.0251 0.0826
Mycobacterium tuberculosis Conserved protein 0.0074 0.0646 0.0777
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0088 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0251 0.0296
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0646 0.0761
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0137 0.13 0.395
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0215 0.0654
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0215 0.0654
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.344 0.4148
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.344 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0022 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0108 0.0329
Giardia lamblia DINP protein human, muc B family 0.0023 0.012 0.0236
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0074 0.0646 0.1963
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0254 0.2502 0.2502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1058 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0215 0.186
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0214 0.2089 0.25
Treponema pallidum fructose-bisphosphate aldolase 0.0492 0.4961 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0646 0.1963
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0022 0.0078
Brugia malayi Cathepsin L-like precursor 0.002 0.0088 0.0267
Loa Loa (eye worm) hypothetical protein 0.0071 0.0617 0.1875
Brugia malayi TAR-binding protein 0.0065 0.0546 0.1658
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0366 0.3326
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1058 1
Leishmania major cathepsin L-like protease 0.0077 0.0675 0.6305
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0164
Mycobacterium ulcerans lipase LipD 0.0074 0.0646 0.0755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Echinococcus granulosus bloom syndrome protein 0.0029 0.0178 0.021
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.012 0.0943
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2472 0.4965
Onchocerca volvulus 0.0014 0.0022 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0108 0.0329
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0646 0.0761
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0646 0.127
Echinococcus multilocularis dna polymerase eta 0.0023 0.012 0.012
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0431 0.0507
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0214 0.2089 0.2518
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.033 0.131
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.033 0.063
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.012 0.0118
Echinococcus multilocularis caspase 8 0.0021 0.01 0.01
Schistosoma mansoni alpha glucosidase 0.0044 0.033 0.0389
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0047 0.0057
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0254 0.2502 0.2999
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0243 0.0311
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.012 0.0363
Echinococcus multilocularis cysteine protease 0.002 0.0088 0.0088
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0295 0.0559
Schistosoma mansoni pyruvate kinase 0.0021 0.0092 0.0109
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.344 0.4133
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0047 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1058 0.2103
Plasmodium falciparum thioredoxin reductase 0.0094 0.0848 0.2459
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0295 0.0982
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0329
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8492 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.012 0.0363
Schistosoma mansoni DNA helicase recq5 0.0012 0.0002 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0215 0.0564
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0039 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0267
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0022 0.0007
Treponema pallidum hypothetical protein 0.0345 0.344 0.6826
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0646 0.0646
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0108 0.0108
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0108 0.0108
Echinococcus granulosus RUN 0.0071 0.0617 0.0727
Toxoplasma gondii ABC1 family protein 0.0074 0.0646 0.2574
Echinococcus multilocularis lamin 0.0033 0.0215 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0251 0.0296
Loa Loa (eye worm) hypothetical protein 0.0047 0.0366 0.1113
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0646 0.0755
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0238 0.2336 0.2798
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0108 0.0329
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2476 0.7525
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.158 0.316
Onchocerca volvulus 0.0022 0.0108 0.0318
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0295 0.0982
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.033 0.063
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0002 0.0002
Schistosoma mansoni lamin 0.0033 0.0215 0.0254
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0171 0.0673
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0411 0.0793
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0492 0.4961 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0257 0.0303
Brugia malayi MH2 domain containing protein 0.0144 0.1369 0.416
Trypanosoma cruzi metacaspase, putative 0.0021 0.01 0.075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0739
Loa Loa (eye worm) hypothetical protein 0.01 0.0916 0.2785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0492 0.4961 1
Toxoplasma gondii cathepsin CPL 0.002 0.0088 0.0341
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0215 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0546 0.0642
Entamoeba histolytica hypothetical protein 0.0037 0.0257 0.0483
Loa Loa (eye worm) glutaminase 0.033 0.3291 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.012 0.0204
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0205 0.0205
Plasmodium falciparum metacaspase 1 0.0021 0.01 0.0283
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0215 0.186
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.033 0.063
Schistosoma mansoni polycystin 1-related 0.0071 0.0617 0.0727
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0022 0.0067
Echinococcus granulosus caspase 2 0.0071 0.0614 0.0723
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0215 0.0617
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0022 0.0067
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0848 0.2416
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0088 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0739
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0108 0.0329
Leishmania major cathepsin L-like protease 0.0077 0.0675 0.6305
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0047 0.024
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0088 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0646 0.127
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0088 0.0103
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.012 0.0943
Trypanosoma brucei metacaspase 5, putative 0.0021 0.01 0.075
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.0643 0.0751
Onchocerca volvulus 0.002 0.0088 0.0245
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0171 0.0435
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0215 0.186
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0171 0.1435
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0108 0.0108
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0108 0.0128
Plasmodium vivax hypothetical protein, conserved 0.0021 0.01 0.0227
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0366 0.0704
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0215 0.0428
Trypanosoma cruzi metacaspase, putative 0.0021 0.01 0.075
Leishmania major cathepsin L-like protease 0.002 0.0088 0.0635
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Trypanosoma brucei metacaspase 0.0021 0.01 0.075
Brugia malayi hypothetical protein 0.0037 0.0257 0.0782
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0178 0.0323
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.158 0.316
Onchocerca volvulus 0.002 0.0088 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0108 0.0329
Loa Loa (eye worm) fibroinase 0.002 0.0088 0.0267
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0636
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0215 0.186
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0108 0.0108
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0215 0.0233
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0366 0.3326
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0295 0.2637
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0646 0.1963
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0215 0.186
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.033 0.063
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0546 0.0546
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.012 0.0204
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.0643 0.0643
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0854 0.0854
Trichomonas vaginalis glutaminase, putative 0.033 0.3291 0.6621
Brugia malayi Cathepsin L-like precursor 0.002 0.0088 0.0267
Schistosoma mansoni hypothetical protein 0.0511 0.5161 0.6077
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0251 0.0996
Brugia malayi Cathepsin L-like precursor 0.002 0.0088 0.0267
Echinococcus granulosus pyruvate kinase 0.004 0.0295 0.0347
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0646 0.127
Echinococcus granulosus Polycystic kidney disease protein 0.0071 0.0617 0.0727
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0164
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0295 0.0982
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0739
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0215 0.186
Brugia malayi Thioredoxin reductase 0.0094 0.0848 0.2577
Schistosoma mansoni thyroid hormone receptor 0.0147 0.1396 0.1644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) doublecortin family protein 0.0071 0.0617 0.1875
Echinococcus multilocularis caspase 2 0.0071 0.0614 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8492 1
Schistosoma mansoni loxhd1 0.0071 0.0617 0.0727
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0106
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.033 0.063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.128 0.1507
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0164
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0205 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0088 0.014
Onchocerca volvulus 0.002 0.0088 0.0245
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0215 0.0256
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0646 0.1826
Onchocerca volvulus 0.0114 0.1055 0.3679
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.01 0.0389
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.5651 0.5651
Loa Loa (eye worm) pyruvate kinase 0.004 0.0295 0.0897
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0223 0.0267
Chlamydia trachomatis pyruvate kinase 0.004 0.0295 0.0534
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2835 0.57
Plasmodium falciparum pyruvate kinase 0.004 0.0295 0.0851
Schistosoma mansoni alpha-glucosidase 0.0169 0.1629 0.1918
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0492 0.4961 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0088 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0223 0.0267
Brugia malayi cathepsin L-like precursor 0.0014 0.0019 0.0057
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1058 0.1246
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0916 0.1079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Onchocerca volvulus 0.0163 0.1565 0.549
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0215 0.186
Brugia malayi Cathepsin L-like precursor 0.0014 0.0019 0.0057
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0254 0.2502 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0366 0.1113
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0783 0.2225
Loa Loa (eye worm) hypothetical protein 0.0028 0.0169 0.0514
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0215 0.0396
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.012 0.0943
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0164
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0108 0.0329
Echinococcus granulosus GPCR family 2 0.0064 0.0536 0.0632
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0108 0.0329
Brugia malayi Muscleblind-like protein 0.018 0.1743 0.5297
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0814 0.8292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.012 0.0943
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.0643 0.0751
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0059 0.0179
Echinococcus granulosus muscleblind protein 0.018 0.1743 0.2053
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0022 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.1396 0.1396
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0215 0.0849
Onchocerca volvulus 0.0014 0.0022 0.0012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0108 0.0128
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0108 0.0318
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0251 0.0251
Brugia malayi hypothetical protein 0.0163 0.1565 0.4756
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0022 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0108 0.0329
Onchocerca volvulus 0.002 0.0088 0.0245
Entamoeba histolytica hypothetical protein 0.0037 0.0257 0.0483
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0024
Loa Loa (eye worm) beta-lactamase 0.0074 0.0646 0.1963
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0092 0.036
Mycobacterium ulcerans glutaminase 0.033 0.3291 0.3952
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0166 0.1599 0.1926
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8492 0.8492
Entamoeba histolytica hypothetical protein 0.0028 0.0171 0.0308
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0108 0.0128
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0257 0.0257
Schistosoma mansoni caspase-7 (C14 family) 0.0071 0.0614 0.0723
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0022 0.0024
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0088 0.0248
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1369 0.416
Echinococcus multilocularis lamin dm0 0.0033 0.0215 0.0215
Echinococcus multilocularis pyruvate kinase 0.0021 0.0092 0.0092
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0215 0.0189
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0002 0.0007
Schistosoma mansoni DNA polymerase eta 0.0023 0.012 0.0141
Plasmodium falciparum glutathione reductase 0.0094 0.0848 0.2459
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0646 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0254 0.2502 0.2999
Mycobacterium tuberculosis Conserved protein 0.0074 0.0646 0.0777
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.012 0.0141
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.01 0.0389
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0108 0.0128
Onchocerca volvulus Cathepsin L homolog 0.002 0.0088 0.0245
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.01 0.0164
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0848 0.2577
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0205 0.0245
Schistosoma mansoni pyruvate kinase 0.004 0.0295 0.0347
Onchocerca volvulus 0.002 0.0088 0.0245
Echinococcus granulosus lipoxygenase domain containing protein 0.0071 0.0617 0.0727
Echinococcus multilocularis musashi 0.0033 0.0215 0.0215
Trypanosoma cruzi metacaspase, putative 0.0021 0.01 0.075
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0047 0.01
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0088 0.0635
Schistosoma mansoni glutaminase 0.033 0.3291 0.3875
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0295 0.0897
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.012 0.012
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1912 0.2252
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0214 0.2089 0.2518
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0546 0.0642
Toxoplasma gondii thioredoxin reductase 0.0094 0.0848 0.3382
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0002 0.0002
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0366 0.044
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0074 0.0643 0.1954
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.01 0.075
Loa Loa (eye worm) hypothetical protein 0.0064 0.0536 0.163
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0169 0.0514
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.012 0.0204
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1058 0.3214
Treponema pallidum NADH oxidase 0.0032 0.0215 0.0092
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0047 0.024
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0214 0.2089 0.2518
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0366 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0045 0.0221
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0366 0.0417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0215 0.186
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.01 0.0164
Echinococcus multilocularis dna polymerase kappa 0.0023 0.012 0.012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0108 0.0128
Schistosoma mansoni hypothetical protein 0.0064 0.0536 0.0632
Onchocerca volvulus 0.0047 0.0366 0.1235
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0088 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0088 0.014
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0295 0.0559
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0329
Plasmodium falciparum glutathione reductase 0.0032 0.0215 0.0617
Brugia malayi hypothetical protein 0.005 0.0393 0.1194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.012 0.0943
Echinococcus granulosus tumor protein p63 0.0365 0.365 0.4298
Trypanosoma brucei unspecified product 0.0023 0.012 0.0943
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0088 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1058 0.2103
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0022 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0088 0.014
Schistosoma mansoni coup transcription factor 0.0022 0.0108 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0164
Loa Loa (eye worm) RecQ helicase 0.0029 0.0178 0.0542
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0492 0.4961 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0108 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0057
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0108 0.0128
Schistosoma mansoni intermediate filament proteins 0.0033 0.0215 0.0254
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0366 0.0704
Echinococcus granulosus lamin 0.0033 0.0215 0.0254
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0171 0.0673
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1167 0.1167
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0411 0.0484
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0047 0.0057
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0366 0.1113
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0047 0.0057
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.033 0.063
Schistosoma mansoni hypothetical protein 0.0511 0.5161 0.6077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0088 0.014
Onchocerca volvulus 0.0033 0.0215 0.0698
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0329
Leishmania major cathepsin L-like protease 0.002 0.0088 0.0635
Loa Loa (eye worm) hypothetical protein 0.0047 0.0366 0.1113
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0814 0.8292 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0039 0.0163
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0303
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0087 0.0783 0.092
Trypanosoma brucei polo-like protein kinase 0.0114 0.1058 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0243 0.0647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0108 0.0329
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0215 0.186
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0295 0.2637
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0171 0.018
Plasmodium vivax pyruvate kinase, putative 0.004 0.0295 0.0799
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0916 0.0916
Loa Loa (eye worm) acetyltransferase 0.0175 0.1688 0.5129
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0276 0.2729 0.3214
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0108 0.0108
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0022 0.0067
Trypanosoma brucei metacaspase MCA2 0.0021 0.01 0.075
Plasmodium falciparum metacaspase-like protein 0.0021 0.01 0.0283
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0854 0.1006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0047 0.0057
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1912 0.1912
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0366 0.0417
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0916 0.1079
Echinococcus multilocularis lipoxygenase domain containing protein 0.0071 0.0617 0.0617
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0205 0.0205
Onchocerca volvulus 0.0053 0.0431 0.1463
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0108 0.0329
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1167 0.1374
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0546 0.0642
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.033 0.0389
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0108 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Toxoplasma gondii hypothetical protein 0.0087 0.0783 0.3121
Loa Loa (eye worm) hypothetical protein 0.005 0.0393 0.1194
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0646 0.1963
Loa Loa (eye worm) glutaminase 2 0.033 0.3291 1
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2472 0.4965
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0536 0.163
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0022 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0108 0.0128
Onchocerca volvulus 0.002 0.0088 0.0245
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.012 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0047 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1058 0.2103
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0492 0.4961 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0088 0.014
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0205 0.081
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0205 0.0205
Schistosoma mansoni alpha-glucosidase 0.0169 0.1629 0.1918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.01 0.0164
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0067
Brugia malayi Cathepsin L-like precursor 0.002 0.0088 0.0267
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0047 0.0057
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0041 0.0041
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0295 0.0897
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.012 0.0943
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0005 0.0014
Echinococcus granulosus neuropeptide s receptor 0.0558 0.5651 0.6654
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0366 0.0417
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0125 0.0381
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0047 0.0057
Entamoeba histolytica hypothetical protein 0.0037 0.0257 0.0483
Schistosoma mansoni lipoxygenase 0.0147 0.14 0.1649
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0205 0.081
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0646 0.6025
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0088 0.0267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.128 0.1507
Onchocerca volvulus Cathepsin L homolog 0.002 0.0088 0.0245
Schistosoma mansoni hypothetical protein 0.0064 0.0536 0.0632
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0088 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.158 0.316
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0814 0.8292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0021 0.01 0.0303
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0074 0.0643 0.0757
Echinococcus multilocularis muscleblind protein 0.018 0.1743 0.1743
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0205 0.0205
Onchocerca volvulus 0.0074 0.0646 0.2227
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0022 0.0007
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0295 0.2637
Leishmania major cathepsin L-like protease 0.002 0.0088 0.0635
Brugia malayi beta-lactamase 0.0074 0.0646 0.1963
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2472 0.4965
Echinococcus multilocularis caspase 0.0021 0.01 0.01
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.033 0.1003
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0164
Schistosoma mansoni kinase 0.0058 0.0478 0.0563
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0238 0.028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0329
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0366 0.0704
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0462 0.0898
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.033 0.063
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.033 0.1003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0214 0.2089 0.2518
Mycobacterium ulcerans beta-lactamase 0.0074 0.0646 0.0755
Loa Loa (eye worm) hypothetical protein 0.0074 0.0646 0.1963
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0178 0.0178
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0205 0.1767
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.5651 0.5651
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.2472 0.7513
Schistosoma mansoni hypothetical protein 0.0064 0.0536 0.0632
Echinococcus multilocularis lipoxygenase domain containing protein 0.0071 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Echinococcus granulosus peptidase Clp S14 family 0.0166 0.1599 0.1882
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1637 0.1928
Onchocerca volvulus 0.0023 0.0118 0.0354
Echinococcus multilocularis pyruvate kinase 0.004 0.0295 0.0295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0546 0.1658
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1688 0.1988
Mycobacterium tuberculosis Probable dehydrogenase 0.0214 0.2089 0.2518
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0057
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0125 0.0381
Mycobacterium ulcerans hypothetical protein 0.0074 0.0646 0.0755
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0108 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0462 0.0898
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0215 0.0849
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0536 0.163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0108 0.0329
Trypanosoma brucei pyruvate kinase 1 0.004 0.0295 0.2637
Echinococcus granulosus cathepsin l1 0.0014 0.0019 0.0022
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0022 0.0078
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0039 0.0041
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0205 0.1767
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1369 0.416
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2472 0.4965
Giardia lamblia Pyruvate kinase 0.0021 0.0092 0.0182
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0067
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.1957 0.5948
Trichomonas vaginalis esterase, putative 0.0074 0.0646 0.127
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0022 0.0024
Leishmania major trypanothione reductase 0.0094 0.0848 0.7974
Echinococcus multilocularis geminin 0.0511 0.5161 0.5161
Schistosoma mansoni hypothetical protein 0.005 0.0393 0.0463
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0546 0.0642
Trypanosoma brucei trypanothione reductase 0.0094 0.0848 0.7974
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0675 0.6305
Schistosoma mansoni thyroid hormone receptor 0.0147 0.1396 0.1644
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0739
Brugia malayi glutaminase DH11.1 0.033 0.3291 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1058 0.2103
Loa Loa (eye worm) pyruvate kinase 0.004 0.0295 0.0897
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0108 0.0329
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.01 0.0164
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.01 0.0164
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0251 0.0251
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0024
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1912 0.5811
Loa Loa (eye worm) hypothetical protein 0.018 0.1743 0.5297
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0039 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0108 0.0329
Schistosoma mansoni hypothetical protein 0.0125 0.1167 0.1374
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0022 0.0024
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0088 0.0267
Schistosoma mansoni rab6-interacting 0.0071 0.0617 0.0727
Echinococcus granulosus dna polymerase kappa 0.0023 0.012 0.0141
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0108 0.0128
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0108 0.0128
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0215 0.0189
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0215 0.0654
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0108 0.0128
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0257 0.0303
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.012 0.0141
Loa Loa (eye worm) hypothetical protein 0.0163 0.1565 0.4756
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0215 0.0652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0254 0.2502 0.2999
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0171 0.018
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0022 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.158 0.316
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0205 0.0205
Brugia malayi steroid hormone receptor 0.0022 0.0108 0.0329
Leishmania major DNA polymerase kappa, putative 0.0023 0.012 0.0943
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0536 0.163
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0606 0.5638
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0251 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1058 0.2103
Brugia malayi beta-lactamase family protein 0.0074 0.0646 0.1963
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.012 0.0142
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0108 0.0329
Schistosoma mansoni caspase-3 (C14 family) 0.0021 0.01 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.128 0.1507
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0002 0.0003
Loa Loa (eye worm) cysteine protease 0.002 0.0088 0.0267
Leishmania major metacaspase, putative 0.0021 0.01 0.075
Brugia malayi isocitrate dehydrogenase 0.0032 0.0205 0.0623
Schistosoma mansoni caspase-7 (C14 family) 0.0021 0.01 0.0117
Onchocerca volvulus Cell death protein 3 homolog 0.0071 0.0614 0.2113
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0088 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.033 0.2974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0169 0.0304
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0215 0.0564
Echinococcus granulosus pyruvate kinase 0.0021 0.0092 0.0109
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0295 0.0354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0108 0.0329
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.01 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.033 0.063
Leishmania major hypothetical protein, conserved 0.0074 0.0646 0.6025
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0108 0.0128
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0215 0.186
Echinococcus multilocularis pyruvate kinase 0.004 0.0295 0.0295
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0411 0.1633
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0276 0.2729 0.2729
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0002 0.0003
Leishmania major pyruvate kinase 0.004 0.0295 0.2637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0215 0.186
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.0643 0.0757
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0223 0.0267
Plasmodium vivax multidomain scavenger receptor, putative 0.0071 0.0617 0.1741
Leishmania major cathepsin L-like protease 0.002 0.0088 0.0635
Onchocerca volvulus 0.0071 0.0617 0.2124
Brugia malayi Cell death protein 3 precursor 0.0071 0.0614 0.1865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0646 0.6025
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.01 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0108 0.0329
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0045 0.0221
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0536 0.0632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0021 0.01 0.0117
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0108 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0088 0.0088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.128 0.128
Echinococcus multilocularis cysteine protease 0.002 0.0088 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0108 0.0128
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0646 0.0777
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.033 0.063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.128 0.1507
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0254 0.2502 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.0393 0.0393
Schistosoma mansoni peptidase Clp (S14 family) 0.0254 0.2502 0.2947
Brugia malayi Cathepsin L-like precursor 0.0014 0.0019 0.0057
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0215 0.0617
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0366 0.044
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0059 0.0179
Leishmania major cathepsin L-like protease 0.0077 0.0675 0.6305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Plasmodium vivax SET domain protein, putative 0.0036 0.0251 0.0671
Plasmodium vivax glutathione reductase, putative 0.0094 0.0848 0.2416
Giardia lamblia Kinase, PLK 0.0114 0.1058 0.2128
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0646 0.0755
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0108 0.0329
Brugia malayi intermediate filament protein 0.0033 0.0215 0.0654
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0205 0.1767
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Echinococcus granulosus caspase 8 0.0021 0.01 0.0117
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.01 0.0164
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0047 0.0142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0108 0.0108
Plasmodium vivax vivapain-2 0.002 0.0088 0.0193
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0215 0.186
Echinococcus granulosus lipoxygenase domain containing protein 0.0071 0.0617 0.0727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0492 0.4961 1
Schistosoma mansoni hypothetical protein 0.0064 0.0536 0.0632
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0108 0.0128
Schistosoma mansoni lamin 0.0033 0.0215 0.0254
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0329
Onchocerca volvulus Cathepsin F homolog 0.002 0.0088 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0205 0.0241
Echinococcus granulosus caspase 0.0021 0.01 0.0117
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0205 0.0589
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0088 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0366 0.1113
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0251 0.0296
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0041 0.0048
Schistosoma mansoni hypothetical protein 0.0071 0.0617 0.0727
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0411 0.0793
Onchocerca volvulus 0.01 0.0916 0.3188
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0646 0.0777
Plasmodium falciparum LCCL domain-containing protein 0.0071 0.0617 0.1788
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0021 0.01 0.0117
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0295 0.033
Loa Loa (eye worm) hypothetical protein 0.0146 0.1387 0.4215
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0646 0.0777
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Brugia malayi ecdysteroid receptor 0.0022 0.0108 0.0329
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0108 0.0128
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.012 0.0141
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0088 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0223 0.0267
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.012 0.0943
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0205 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0108 0.0329
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0329
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0022 0.0026
Echinococcus granulosus cathepsin l1 0.002 0.0088 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0646 0.6025
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0079 0.0306
Echinococcus multilocularis tumor protein p63 0.0365 0.365 0.365
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0916 0.2785
Trypanosoma brucei metacaspase MCA3 0.0021 0.01 0.075
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.012 0.0943
Loa Loa (eye worm) glutathione reductase 0.0094 0.0848 0.2577
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.5651 0.6654
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0215 0.0233
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1058 0.3214
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0254 0.2502 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0215 0.0654
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0171 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.128 0.1507
Schistosoma mansoni hypothetical protein 0.0137 0.13 0.1531
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1058 0.2103
Onchocerca volvulus 0.005 0.0393 0.1329
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0125
Loa Loa (eye worm) hypothetical protein 0.0071 0.0617 0.1875
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0205 0.0623
Trypanosoma brucei glucosidase, putative 0.0044 0.033 0.2974
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0108 0.0329
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0783 0.2269
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.01 0.0389
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.033 0.063
Leishmania major cathepsin L-like protease 0.002 0.0088 0.0635
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.158 0.316
Onchocerca volvulus 0.0014 0.0022 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0088 0.014
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0546 0.1658
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0088 0.0248
Onchocerca volvulus 0.0286 0.2835 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0067
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0205 0.0535
Schistosoma mansoni DNA helicase recq1 0.0012 0.0002 0.0003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0039 0.0163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0251 0.0296
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.033 0.063
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0739
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1058 0.2103
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0002 0.0007
Trypanosoma cruzi metacaspase, putative 0.0021 0.01 0.075
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.012 0.0142
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0178 0.0323
Loa Loa (eye worm) hypothetical protein 0.0254 0.2502 0.7605
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.128 0.128
Plasmodium falciparum thioredoxin reductase 0.0032 0.0215 0.0617
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1672 0.3346
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0215 0.0215
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1672 0.3346
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.1957 0.5948
Mycobacterium ulcerans pyruvate kinase 0.004 0.0295 0.033
Mycobacterium leprae Probable lipase LipE 0.0074 0.0646 0.0755
Brugia malayi Cathepsin L-like precursor 0.002 0.0088 0.0267
Mycobacterium tuberculosis Probable reductase 0.0214 0.2089 0.2518
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0646 0.127
Brugia malayi Probable ClpP-like protease 0.0254 0.2502 0.7605
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2472 0.4965
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0675 0.6305
Echinococcus multilocularis GPCR, family 2 0.0064 0.0536 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0366 0.0417
Echinococcus multilocularis pyruvate kinase 0.0021 0.0092 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Echinococcus granulosus pyruvate kinase 0.0021 0.0092 0.0109
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0088 0.014
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1058 0.2103
Brugia malayi nuclear hormone receptor 0.0022 0.0108 0.0329
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0022 0.0026
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.128 0.3889
Brugia malayi Cathepsin L-like precursor 0.002 0.0088 0.0267
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.012 0.0363
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0002 0.00000000022531
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0108 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.012 0.0943
Leishmania major cysteine peptidase A (CPA) 0.002 0.0088 0.0635
Loa Loa (eye worm) oxidoreductase 0.0014 0.0022 0.0067
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0205 0.1767
Onchocerca volvulus 0.0033 0.0215 0.0698
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0205 0.1767
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0366 0.3326
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0019 0.0022
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0166 0.1599 0.1926
Entamoeba histolytica hypothetical protein 0.0037 0.0257 0.0483
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1058 0.3689
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.344 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0254 0.2502 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0142
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0215 0.0253
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.01 0.0164
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0411 0.1633
Schistosoma mansoni lipoxygenase 0.0276 0.2729 0.3214
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0171 0.018
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0215 0.0189
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.158 0.316
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0108 0.0128
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1058 0.1058
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.158 0.5545
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0366 0.0734
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0366 0.1059
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0074 0.0643 0.5996
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0295 0.1171
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0536 0.0632
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0108 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.158 0.316
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0022 0.0024
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0411 0.1137
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0675 0.6305
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0108 0.0329
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0492 0.4961 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0329
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0088 0.014
Loa Loa (eye worm) hypothetical protein 0.0036 0.0251 0.0764
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1688 0.5129
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0108 0.0329
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0675 0.6305
Echinococcus granulosus tar DNA binding protein 0.0065 0.0546 0.0642
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0022 0.0078
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0047 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.012 0.0943
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0215 0.0396
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0366 0.0417
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0215 0.186
Loa Loa (eye worm) hypothetical protein 0.0074 0.0646 0.1963
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0115 0.0136
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.033 0.033
Brugia malayi Pre-SET motif family protein 0.0251 0.2476 0.7525
Loa Loa (eye worm) pyruvate kinase 0.004 0.0295 0.0897
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.344 0.4133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0081 0.0174
Echinococcus granulosus geminin 0.0511 0.5161 0.6077
Echinococcus multilocularis peptidase Clp (S14 family) 0.0166 0.1599 0.1599
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0783 0.1278
Onchocerca volvulus 0.002 0.0088 0.0245
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.13 0.395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0492 0.4961 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0238 0.2336 0.2816
Brugia malayi hypothetical protein 0.0071 0.0617 0.1875
Onchocerca volvulus 0.0074 0.0646 0.2227
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0329
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0215 0.186
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0254 0.2502 0.7272
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0366 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0088 0.014
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0646 0.127
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0547 0.1661
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1688 0.1688

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (binding) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 17.7407 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 60.1198 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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