Detailed information for compound 1411983

Basic information

Technical information
  • TDR Targets ID: 1411983
  • Name: 2-(2-chlorophenyl)-5-[4-(furan-2-carbonyl)pip erazin-1-yl]-1,3-oxazole-4-carbonitrile
  • MW: 382.8 | Formula: C19H15ClN4O3
  • H donors: 0 H acceptors: 3 LogP: 3.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1nc(oc1N1CCN(CC1)C(=O)c1ccco1)c1ccccc1Cl
  • InChi: 1S/C19H15ClN4O3/c20-14-5-2-1-4-13(14)17-22-15(12-21)19(27-17)24-9-7-23(8-10-24)18(25)16-6-3-11-26-16/h1-6,11H,7-10H2
  • InChiKey: IHJDIFPQYPITRL-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(2-chlorophenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]oxazole-4-carbonitrile
  • 2-(2-chlorophenyl)-5-[4-(2-furyl-oxomethyl)-1-piperazinyl]-4-oxazolecarbonitrile
  • 2-(2-chlorophenyl)-5-(4-furan-2-ylcarbonylpiperazin-1-yl)-1,3-oxazole-4-carbonitrile
  • ZINC06698108

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) TK/EPH protein kinase 0.0344 0.0903 0.0885
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0153 0.0201 0.0176
Brugia malayi Fibronectin type III domain containing protein 0.0214 0.0426 0.0395
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1199 0.4041 0.4163
Brugia malayi MAP kinase sur-1 0.0221 0.0451 0.042
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0191 0.0341 0.0271
Brugia malayi protein unc-22 0.0124 0.0096 0.0064
Echinococcus multilocularis epidermal growth factor receptor 0.112 0.3751 0.3861
Loa Loa (eye worm) hypothetical protein 0.0254 0.057 0.0551
Entamoeba histolytica protein kinase domain containing protein 0.0164 0.0242 0.022
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0124 0.0096 0.0076
Schistosoma mansoni tyrosine kinase 0.1022 0.3394 0.3491
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0341 0.0315
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0558 0.1688 0.1716
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Loa Loa (eye worm) AGC/PKA protein kinase 0.0191 0.0341 0.0321
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Echinococcus granulosus titin 0.0124 0.0096 0.006
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0164 0.0242 0.0168
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0136 0.0138 0.0058
Schistosoma mansoni growth factor receptor-bound protein 0.0162 0.0234 0.0204
Loa Loa (eye worm) hypothetical protein 0.0202 0.0381 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0757 0.242 0.2508
Giardia lamblia Kinase, CK1 Casein kinase 0.0222 0.0455 0.039
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0663 0.2075 0.2119
Brugia malayi protein kinase C3,putative 0.0331 0.0855 0.0825
Entamoeba histolytica protein kinase domain containing protein 0.0248 0.0548 0.0538
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Echinococcus multilocularis aurora kinase A 0.0296 0.0726 0.0715
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0108 0.0112
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0224 0.0461 0.0396
Schistosoma mansoni protein kinase 0.0136 0.0138 0.0103
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0129 0.0114 0.0078
Onchocerca volvulus 0.0408 0.1136 0.1089
Echinococcus multilocularis Glutaredoxin protein 5 0.0347 0.0914 0.0911
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0093 0.0057
Onchocerca volvulus 0.0357 0.0951 0.0895
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0296 0.0726 0.0715
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0268 0.0625 0.061
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0133 0.0127 0.0107
Echinococcus granulosus casein kinase I alpha 0.0222 0.0455 0.0433
Schistosoma mansoni serine/threonine protein kinase 0.0303 0.0753 0.0743
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0322 0.0822 0.0792
Echinococcus multilocularis rac serine:threonine kinase 0.0433 0.1231 0.124
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0183 0.031 0.029
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0283 0.0254
Brugia malayi Sex muscle abnormal protein 5 0.0162 0.0234 0.0203
Echinococcus granulosus c src tyrosine kinase 0.0259 0.0591 0.0575
Trichomonas vaginalis CAMK family protein kinase 0.2726 0.9652 1
Trypanosoma cruzi casein kinase, putative 0.0222 0.0455 0.039
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0149 0.0187 0.0167
Trichomonas vaginalis AGC family protein kinase 0.0391 0.1076 0.1114
Schistosoma mansoni tyrosine kinase 0.0259 0.0591 0.0575
Schistosoma mansoni cell adhesion molecule 0.0266 0.0616 0.0601
Echinococcus multilocularis Immunoglobulin 0.0202 0.0381 0.0356
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0138 0.0103
Plasmodium falciparum calcium-dependent protein kinase 5 0.0136 0.0138 0.059
Loa Loa (eye worm) hypothetical protein 0.0128 0.011 0.009
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.0357 0.037
Echinococcus multilocularis death associated protein kinase 1 0.1724 0.5973 0.6173
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.0684 0.0671
Echinococcus granulosus casein kinase I alpha 0.0222 0.0455 0.0433
Entamoeba histolytica protein kinase, putative 0.0214 0.0426 0.041
Schistosoma mansoni serine/threonine protein kinase 0.039 0.1073 0.1076
Echinococcus multilocularis serine:threonine protein kinase 38 0.0391 0.1076 0.1079
Echinococcus multilocularis serine:threonine protein kinase N2 0.0138 0.0145 0.0111
Schistosoma mansoni tyrosine kinase 0.0437 0.1243 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0341 0.0315
Trichomonas vaginalis AGC family protein kinase 0.0432 0.1225 0.1269
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0202 0.0381 0.0356
Plasmodium falciparum protein kinase, putative 0.0164 0.0242 0.1553
Trichomonas vaginalis CAMK family protein kinase 0.0313 0.0789 0.0817
Echinococcus granulosus Immunoglobulin 0.0202 0.0381 0.0356
Echinococcus granulosus tyrosine protein kinase Fyn 0.0437 0.1243 0.1253
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0357 0.0951 0.0908
Trichomonas vaginalis AGC family protein kinase 0.0296 0.0726 0.0752
Loa Loa (eye worm) hypothetical protein 0.0129 0.0114 0.0094
Onchocerca volvulus 0.0183 0.031 0.0224
Echinococcus granulosus cGMP dependent protein kinase 1 0.0175 0.0283 0.0254
Loa Loa (eye worm) hypothetical protein 0.0217 0.0437 0.0418
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0129 0.0114 0.0078
Echinococcus granulosus tyrosine protein kinase HCK 0.0275 0.0648 0.0634
Entamoeba histolytica PH domain containing protein kinase, putative 0.0433 0.1231 0.1247
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0345 0.0906 0.0877
Leishmania major protein kinase, putative 0.0224 0.0461 0.0396
Schistosoma mansoni vesicular amine transporter 0.0202 0.0381 0.0356
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0195 0.0355 0.0336
Echinococcus multilocularis calcium activated potassium channel 0.0296 0.0725 0.0714
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0222 0.0455 0.039
Echinococcus multilocularis tyrosine protein kinase shark 0.0183 0.031 0.0283
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0357 0.0951 0.0932
Echinococcus multilocularis N chimaerin 0.0181 0.0304 0.0276
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.0451 0.0429
Schistosoma mansoni ephrin receptor 0.0291 0.0708 0.0696
Echinococcus granulosus roundabout 2 0.0311 0.078 0.0771
Echinococcus granulosus dual specificity 0.0338 0.0879 0.0875
Loa Loa (eye worm) hypothetical protein 0.0162 0.0234 0.0215
Echinococcus granulosus serine:threonine protein kinase PLK1 0.2726 0.9652 1
Schistosoma mansoni tyrosine kinase 0.0259 0.0591 0.0575
Echinococcus multilocularis protein kinase c epsilon type 0.0489 0.1435 0.1453
Echinococcus granulosus tyrosine protein kinase Blk 0.036 0.0963 0.0961
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0107 0.0032 0.0012
Schistosoma mansoni growth factor receptor-bound protein 0.0162 0.0234 0.0204
Plasmodium vivax protein kinase, putative 0.0123 0.0091 0.0158
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0391 0.1076 0.1079
Schistosoma mansoni tyrosine kinase 0.1022 0.3394 0.3491
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.0548 0.053
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0191 0.0341 0.0271
Entamoeba histolytica protein kinase, putative 0.0165 0.0247 0.0224
Echinococcus multilocularis Protein kinase C, brain isozyme 0.057 0.1731 0.1761
Echinococcus multilocularis cyclin dependent kinase 1 0.0285 0.0684 0.0671
Brugia malayi Protein kinase domain containing protein 0.0183 0.031 0.0279
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0136 0.0138 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.2726 0.9652 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0138 0.0103
Entamoeba histolytica PH domain containing protein kinase, putative 0.021 0.041 0.0394
Loa Loa (eye worm) TK/ABL protein kinase 0.0811 0.2618 0.2603
Brugia malayi Protein kinase domain containing protein 0.0551 0.1664 0.1637
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0136 0.0138 0.0118
Plasmodium falciparum calcium-dependent protein kinase 3 0.0136 0.0138 0.059
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0663 0.2075 0.2119
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0204 0.0387 0.2883
Trichomonas vaginalis AGC family protein kinase 0.0191 0.0341 0.0353
Brugia malayi cell division control protein 2 homolog 0.0285 0.0684 0.0654
Loa Loa (eye worm) hypothetical protein 0.0229 0.0478 0.0459
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.0725 0.0714
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0338 0.0879 0.0833
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0093 0.0096
Trichomonas vaginalis AGC family protein kinase 0.038 0.1034 0.1071
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.0568 0.0551
Loa Loa (eye worm) hypothetical protein 0.0427 0.1205 0.1188
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0162 0.0234 0.0204
Echinococcus multilocularis protein tyrosine kinase 0.0635 0.1972 0.2011
Trypanosoma brucei rac serine-threonine kinase, putative 0.0757 0.242 0.2444
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0646 0.2012 0.2052
Schistosoma mansoni serine/threonine protein kinase 0.0391 0.1076 0.1079
Trypanosoma cruzi casein kinase, putative 0.0222 0.0455 0.039
Plasmodium falciparum casein kinase 2, alpha subunit 0.0204 0.0387 0.2883
Trichomonas vaginalis AGC family protein kinase 0.0757 0.242 0.2508
Loa Loa (eye worm) hypothetical protein 0.0183 0.031 0.029
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.036 0.0963 0.0961
Loa Loa (eye worm) CDC7 protein kinase 0.0128 0.0108 0.0088
Echinococcus multilocularis tyrosine protein kinase Blk 0.036 0.0963 0.0961
Leishmania major protein kinase A catalytic subunit 0.0191 0.0341 0.0271
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0345 0.0906 0.0903
Entamoeba histolytica protein kinase domain containing protein 0.0296 0.0726 0.0722
Leishmania major protein kinase, putative 0.0296 0.0726 0.0673
Plasmodium vivax glycogen synthase kinase 3, putative 0.0357 0.0951 0.8066
Trypanosoma cruzi casein kinase, putative 0.0222 0.0455 0.039
Trichomonas vaginalis CAMK family protein kinase 0.2726 0.9652 1
Trichomonas vaginalis CMGC family protein kinase 0.0204 0.0387 0.0401
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0542 0.1628 0.1654
Schistosoma mansoni tyrosine kinase 0.0183 0.031 0.0283
Echinococcus multilocularis serine:threonine protein kinase 0.0313 0.0789 0.0781
Onchocerca volvulus 0.042 0.1183 0.1138
Trypanosoma brucei cdc2-related kinase 3 0.0285 0.0684 0.0629
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0551 0.1664 0.1691
Brugia malayi Kinase associated domain 1 family protein 0.0229 0.0478 0.0447
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0222 0.0455 0.0435
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Schistosoma mansoni protein kinase 0.0635 0.1973 0.2012
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0346 0.0909 0.0941
Brugia malayi Doublecortin family protein 0.0193 0.0346 0.0315
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0488 0.143 0.1412
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0124 0.0094 0.0058
Plasmodium falciparum casein kinase 1 0.0222 0.0455 0.3506
Loa Loa (eye worm) hypothetical protein 0.0105 0.0023 0.0003
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0181 0.0304 0.0276
Echinococcus multilocularis 0.0509 0.1508 0.1529
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Echinococcus multilocularis protein kinase c iota type 0.0655 0.2045 0.2087
Echinococcus multilocularis epidermal growth factor receptor 0.175 0.6067 0.6271
Loa Loa (eye worm) TK/INSR protein kinase 0.1186 0.3995 0.3983
Onchocerca volvulus 0.0128 0.0108 0.0013
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0124 0.0094 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0136 0.0138 0.0143
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Entamoeba histolytica protein kinase, putative 0.0757 0.242 0.2484
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0191 0.0341 0.0271
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0136 0.0138 0.0282
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0127 0.0092
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0437 0.1243 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.0529 0.1582 0.1606
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0296 0.0726 0.5997
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0096 0.006
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.2487 0.8772 0.9085
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0093 0.0096
Schistosoma mansoni nck2/grb4 0.0162 0.0234 0.0204
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0191 0.0341 0.0315
Schistosoma mansoni serine/threonine kinase 0.0391 0.1076 0.1079
Echinococcus granulosus cyclin dependent kinase 5 0.0285 0.0684 0.0671
Brugia malayi P38 map kinase family protein 2 0.0449 0.129 0.1262
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0133 0.0127 0.0132
Schistosoma mansoni nephrin 0.0259 0.059 0.0574
Onchocerca volvulus 0.015 0.0189 0.0098
Entamoeba histolytica protein kinase, putative 0.0338 0.0879 0.0882
Echinococcus granulosus dual specificity 0.0124 0.0093 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.2726 0.9652 1
Trichomonas vaginalis CMGC family protein kinase 0.0357 0.0951 0.0985
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0408 0.1138 0.1144
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0437 0.1243 0.1253
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0191 0.0341 0.0315
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0745 0.2377 0.2361
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0136 0.0138 0.0282
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0646 0.2012 0.2052
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0136 0.0138 0.059
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0414 0.1161 1
Mycobacterium ulcerans hypothetical protein 0.0108 0.0036 0.5
Echinococcus granulosus protein tyrosine kinase 0.0635 0.1972 0.2011
Echinococcus multilocularis 0.0128 0.011 0.0075
Entamoeba histolytica casein kinase, putative 0.0222 0.0455 0.0441
Entamoeba histolytica protein kinase, putative 0.0182 0.0307 0.0287
Echinococcus granulosus Protein kinase C brain isozyme 0.057 0.1731 0.1761
Loa Loa (eye worm) hypothetical protein 0.042 0.1183 0.1165
Echinococcus multilocularis serine threonine protein kinase 0.0474 0.1381 0.1397
Echinococcus granulosus insulin receptor 0.1186 0.3995 0.4116
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0451 0.0467
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0221 0.0451 0.1657
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0338 0.0879 0.0861
Toxoplasma gondii aurora kinase 0.0296 0.0726 0.2864
Schistosoma mansoni tyrosine kinase 0.1186 0.3995 0.4116
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0162 0.0234 0.0215
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.0726 0.0715
Trypanosoma brucei protein kinase, putative 0.0164 0.0242 0.0168
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.067 0.21 0.2084
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0296 0.0726 0.0722
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0347 0.0914 0.0911
Trichomonas vaginalis CK1 family protein kinase 0.0222 0.0455 0.0471
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0224 0.0461 0.0447
Echinococcus granulosus dual specificity protein kinase clk2 0.0196 0.0357 0.0332
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0768 0.246 0.2518
Trichomonas vaginalis CAMK family protein kinase 0.0383 0.1046 0.1084
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0341 0.0315
Brugia malayi Protein kinase domain containing protein 0.0391 0.1076 0.1047
Echinococcus multilocularis neuroglian 0.0247 0.0545 0.0527
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0413 0.1155 0.1138
Brugia malayi protein kinase C II. 0.0489 0.1435 0.1407
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0191 0.0341 0.0315
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0136 0.0138 0.059
Loa Loa (eye worm) hypothetical protein 0.0149 0.0187 0.0167
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0433 0.1228 0.1237
Echinococcus granulosus hypothetical protein 0.0128 0.011 0.0075
Schistosoma mansoni tyrosine kinase 0.0587 0.1794 0.1826
Schistosoma mansoni rap gtpase-activating protein 0.0129 0.0114 0.0078
Loa Loa (eye worm) hypothetical protein 0.0114 0.0058 0.0038
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0285 0.0684 0.0629
Echinococcus granulosus serine threonine protein kinase nrc 0.0414 0.1161 0.1168
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0221 0.0451 0.0386
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0283 0.0254
Loa Loa (eye worm) hypothetical protein 0.0812 0.262 0.2605
Loa Loa (eye worm) TK/ROR protein kinase 0.0142 0.016 0.014
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0982 0.3244 0.323
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0752 0.24 0.2385
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0149 0.0187 0.011
Toxoplasma gondii histone kinase SNF1, putative 0.0149 0.0187 0.0497
Schistosoma mansoni titin 0.0124 0.0096 0.006
Entamoeba histolytica protein kinase, putative 0.0153 0.0201 0.0176
Trypanosoma cruzi polo-like protein kinase, putative 0.2726 0.9652 1
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0212 0.0419 0.0396
Brugia malayi serine/threonine protein kinase 6 0.0296 0.0726 0.0696
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0212 0.0419 0.0396
Trichomonas vaginalis AGC family protein kinase 0.0757 0.242 0.2508
Brugia malayi Variant SH3 domain containing protein 0.0162 0.0234 0.0203
Echinococcus granulosus calcium activated potassium channel 0.0296 0.0725 0.0714
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0357 0.0951 0.0949
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0449 0.129 0.1262
Giardia lamblia Kinase, CDC7 0.0128 0.0108 0.0027
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0142 0.016 0.0126
Loa Loa (eye worm) TK protein kinase 0.036 0.0963 0.0944
Trichomonas vaginalis CK1 family protein kinase 0.0222 0.0455 0.0471
Onchocerca volvulus Tyrosine kinase homolog 0.144 0.4929 0.5058
Echinococcus multilocularis expressed conserved protein 0.0175 0.0283 0.0254
Echinococcus multilocularis mitogen activated protein kinase 3 0.0221 0.0451 0.0429
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.005 0.0012
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0357 0.0951 0.0908
Schistosoma mansoni tyrosine kinase 0.0437 0.1243 0.1253
Trichomonas vaginalis CK1 family protein kinase 0.0222 0.0455 0.0471
Entamoeba histolytica hypothetical protein 0.0338 0.0879 0.0882
Echinococcus multilocularis hypothetical protein 0.0229 0.0478 0.0458
Plasmodium vivax serine/threonine kinase-1, putative 0.0196 0.0357 0.2607
Brugia malayi Protein kinase domain containing protein 0.0183 0.031 0.0279
Schistosoma mansoni protein kinase 0.0635 0.1973 0.2012
Trichomonas vaginalis CAMK family protein kinase 0.0155 0.0207 0.0214
Brugia malayi Protein kinase domain containing protein 0.0413 0.1155 0.1127
Loa Loa (eye worm) TK protein kinase 0.0644 0.2003 0.1986
Echinococcus multilocularis titin 0.0124 0.0096 0.006
Loa Loa (eye worm) TK protein kinase 0.0275 0.0648 0.0629
Trypanosoma cruzi aurora B kinase, putative 0.0296 0.0726 0.0673
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0191 0.0341 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.2726 0.9652 1
Trypanosoma cruzi p21-activated kinase 3, putative 0.0133 0.0127 0.0048
Echinococcus granulosus tyrosine protein kinase Srms 0.0183 0.031 0.0283
Toxoplasma gondii AGC kinase 0.0191 0.0341 0.1175
Schistosoma mansoni protein kinase C mu 0.0475 0.1383 0.1399
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0181 0.0304 0.0276
Giardia lamblia Kinase, CMGC CLK 0.0196 0.0357 0.0288
Echinococcus granulosus tyrosine protein kinase Fyn 0.0437 0.1243 0.1253
Brugia malayi Temporarily assigned gene name protein 59 0.0262 0.0602 0.0571
Plasmodium falciparum calcium-dependent protein kinase 4 0.0136 0.0138 0.059
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0138 0.0103
Loa Loa (eye worm) hypothetical protein 0.0298 0.0734 0.0716
Brugia malayi phosphoinositide-dependent protein kinase I 0.0214 0.0426 0.0395
Echinococcus multilocularis casein kinase I alpha 0.0222 0.0455 0.0433
Echinococcus multilocularis dual specificity 0.0338 0.0879 0.0875
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0127 0.0092
Loa Loa (eye worm) hypothetical protein 0.042 0.1183 0.1165
Onchocerca volvulus 0.0183 0.031 0.0224
Echinococcus multilocularis serine:threonine protein kinase 0.0313 0.0789 0.0781
Echinococcus granulosus tyrosine protein kinase Src42A 0.0263 0.0606 0.059
Echinococcus multilocularis PAK box P21 Rho binding 0.0147 0.0177 0.0145
Echinococcus granulosus tyrosine protein kinase Fyn 0.0437 0.1243 0.1253
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0224 0.0461 0.0396
Toxoplasma gondii casein kinase I 0.0222 0.0455 0.1674
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.0725 0.0714
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0138 0.0103
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0451 0.0467
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0346 0.0319
Plasmodium falciparum serine/threonine protein kinase KIN 0.0149 0.0187 0.104
Trichomonas vaginalis STE family protein kinase 0.0147 0.0177 0.0184
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0313 0.0789 0.077
Brugia malayi Protein kinase domain containing protein 0.067 0.21 0.2075
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0204 0.0387 0.0368
Entamoeba histolytica protein kinase, putative 0.0296 0.0726 0.0722
Entamoeba histolytica protein kinase , putative 0.0296 0.0726 0.0722
Brugia malayi hypothetical protein 0.0268 0.0625 0.0595
Schistosoma mansoni protein kinase 0.0147 0.0177 0.0145
Entamoeba histolytica cell division protein kinase 2, putative 0.0285 0.0684 0.0679
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0646 0.2012 0.1995
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0212 0.0419 0.0396
Schistosoma mansoni tyrosine kinase 0.0176 0.0287 0.0259
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1649 0.5696 0.5687
Brugia malayi RhoGAP domain containing protein 0.0181 0.0304 0.0272
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0121 0.0082 0.0062
Echinococcus multilocularis rho associated protein kinase 0.0952 0.3137 0.3223
Echinococcus granulosus serine:threonine protein kinase 3 0.0745 0.2377 0.2432
Echinococcus multilocularis nervana 2 0.0347 0.0914 0.0911
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0214 0.0426 0.0403
Echinococcus multilocularis mitogen activated protein kinase 11 0.0449 0.129 0.1302
Plasmodium vivax serine/threonine protein kinase, putative 0.0121 0.0082 0.0075
Schistosoma mansoni tyrosine kinase 0.112 0.3751 0.3861
Giardia lamblia Kinase, CMGC GSK 0.0357 0.0951 0.0908
Echinococcus granulosus tyrosine kinase 0.0183 0.031 0.0283
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0433 0.1228 0.121
Echinococcus granulosus epidermal growth factor receptor 0.112 0.3751 0.3861
Echinococcus granulosus activin receptor type 0.0164 0.0242 0.0212
Trypanosoma cruzi cdc2-related kinase 3 0.0285 0.0684 0.0629
Brugia malayi Protein kinase domain containing protein 0.0757 0.242 0.2396
Trypanosoma brucei SNF1-related protein kinases, putative 0.0149 0.0187 0.011
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0202 0.0381 0.0356
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0196 0.0357 0.0288
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0414 0.1161 0.1128
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0133 0.0127 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Loa Loa (eye worm) hypothetical protein 0.0298 0.0734 0.0716
Brugia malayi Temporarily assigned gene name protein 59 0.0129 0.0114 0.0082
Entamoeba histolytica serine/threonine protein kinase, putative 0.0149 0.0187 0.0162
Trichomonas vaginalis AGC family protein kinase 0.0214 0.0426 0.0441
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Leishmania major protein kinase, putative 0.0164 0.0242 0.0168
Echinococcus multilocularis tyrosine protein kinase Abl 0.0499 0.1473 0.1493
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0129 0.0114 0.0034
Onchocerca volvulus 0.0183 0.031 0.0224
Schistosoma mansoni protein kinase 0.0237 0.051 0.0491
Echinococcus granulosus growth factor receptor bound protein 2 0.0162 0.0234 0.0204
Echinococcus granulosus casein kinase ii subunit alpha 0.0204 0.0387 0.0363
Entamoeba histolytica hypothetical protein 0.0404 0.1123 0.1135
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0207 0.0398 0.0374
Echinococcus granulosus myotubularin protein 13 0.0114 0.0058 0.0021
Schistosoma mansoni cell polarity protein 0.014 0.0152 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0338 0.0879 0.0875
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0263 0.0606 0.059
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0129 0.0114 0.0078
Trichomonas vaginalis CMGC family protein kinase 0.0204 0.0387 0.0401
Giardia lamblia Kinase, NEK 0.038 0.1034 0.0995
Loa Loa (eye worm) hypothetical protein 0.0242 0.0527 0.0508
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0414 0.1161 1
Plasmodium falciparum glycogen synthase kinase 3 0.0357 0.0951 0.8066
Onchocerca volvulus Serine\/threonine kinase homolog 0.0207 0.0398 0.0316
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0542 0.1628 0.1654
Echinococcus multilocularis casein kinase I gamma 0.0131 0.0121 0.0085
Plasmodium falciparum serine/threonine protein kinase, putative 0.0296 0.0726 0.5997
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0437 0.1243 0.1253
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0196 0.0357 0.0288
Brugia malayi Protein kinase domain containing protein 0.0237 0.051 0.0479
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0182 0.0307 0.028
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0338 0.0879 0.0833
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Toxoplasma gondii CMGC kinase, CK2 family 0.0204 0.0387 0.1377
Echinococcus granulosus protein kinase shaggy 0.0357 0.0951 0.0949
Schistosoma mansoni serine/threonine-protein kinase 0.0433 0.1231 0.124
Echinococcus multilocularis serine:threonine protein kinase N2 0.0529 0.1582 0.1606
Giardia lamblia Kinase, CMGC MAPK 0.0221 0.0451 0.0386
Loa Loa (eye worm) hypothetical protein 0.0408 0.1136 0.1118
Schistosoma mansoni serine/threonine protein kinase 0.0268 0.0625 0.061
Giardia lamblia Kinase, CMGC CK2 0.0204 0.0387 0.0319
Schistosoma mansoni serine/threonine protein kinase 0.2726 0.9652 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0138 0.0103
Loa Loa (eye worm) AGC/PKA protein kinase 0.0191 0.0341 0.0321
Loa Loa (eye worm) TK/ALK protein kinase 0.0578 0.1761 0.1744
Loa Loa (eye worm) hypothetical protein 0.027 0.0632 0.0613
Entamoeba histolytica p21-activated kinase 0.0231 0.0488 0.0475
Loa Loa (eye worm) GTP-binding protein 0.014 0.0152 0.0132
Echinococcus multilocularis ephrin type A receptor 4 A 0.0291 0.0708 0.0696
Schistosoma mansoni protein kinase 0.0204 0.0387 0.0363
Echinococcus multilocularis dual specificity 0.0124 0.0093 0.0057
Echinococcus granulosus NDR protein kinase 0.0391 0.1076 0.1079
Trypanosoma cruzi cdc2-related kinase 1 0.0285 0.0684 0.0629
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0191 0.0341 0.2459
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0138 0.0103
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0136 0.0138 0.059
Echinococcus granulosus Vam6:Vps39 protein 0.0129 0.0114 0.0078
Trichomonas vaginalis CMGC family protein kinase 0.0204 0.0387 0.0401
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Schistosoma mansoni hypothetical protein 0.0229 0.0478 0.0458
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0196 0.0357 0.0288
Echinococcus multilocularis roundabout 2 0.0311 0.078 0.0771
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0129 0.0114 0.0034
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0259 0.0591 0.0575
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0175 0.0283 0.0254
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0155 0.0207 0.0175
Echinococcus granulosus fibroblast growth factor receptor 4 0.0599 0.1838 0.1872
Entamoeba histolytica protein kinase, putative 0.0391 0.1076 0.1086
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0551 0.1664 0.1641
Schistosoma mansoni protein kinase 0.0222 0.0455 0.0433
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0285 0.0684 0.0629
Brugia malayi Furin-like cysteine rich region family protein 0.175 0.6067 0.6054
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0093 0.0096
Schistosoma mansoni ephrin receptor 0.011 0.0041 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0285 0.0684 0.0709
Trypanosoma cruzi polo-like protein kinase, putative 0.2726 0.9652 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0136 0.0138 0.059
Entamoeba histolytica protein kinase, putative 0.0121 0.0082 0.0053
Echinococcus granulosus protein kinase C gamma type 0.0474 0.1381 0.1397
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0221 0.0451 0.0386
Entamoeba histolytica protein kinase, putative 0.0121 0.0082 0.0053
Echinococcus granulosus titin 0.0124 0.0096 0.006
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.015 0.0191 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.057 0.1731 0.1761
Onchocerca volvulus 0.0952 0.3137 0.3182
Echinococcus multilocularis casein kinase i 0.0222 0.0455 0.0433
Echinococcus granulosus tyrosine kinase 0.036 0.0963 0.0961
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Brugia malayi Protein kinase domain containing protein 0.0131 0.0121 0.0089
Echinococcus granulosus mitogen activated protein kinase 14 0.0449 0.129 0.1302
Schistosoma mansoni kinase 0.1825 0.6342 0.6557
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0449 0.129 0.1262
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0108 0.0112
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0451 0.0467
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0635 0.1973 0.2012
Trichomonas vaginalis AGC family protein kinase 0.0214 0.0426 0.0441
Trichomonas vaginalis STE family protein kinase 0.0212 0.0419 0.0434
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Entamoeba histolytica casein kinase 1, putative 0.0222 0.0455 0.0441
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0285 0.0684 0.0665
Giardia lamblia Kinase, CMGC GSK 0.0357 0.0951 0.0908
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Echinococcus granulosus serine/threonine protein kinase 0.0433 0.1231 0.124
Echinococcus multilocularis dual specificity 0.0124 0.0093 0.0057
Brugia malayi Protein kinase domain containing protein 0.0338 0.0879 0.085
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0391 0.1076 0.1079
Plasmodium vivax calcium-dependent protein kinase, putative 0.0136 0.0138 0.059
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0285 0.0684 0.0665
Entamoeba histolytica protein kinase domain containing protein 0.0357 0.0951 0.0956
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0437 0.1243 0.1253
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2821 1 1
Trichomonas vaginalis AGC family protein kinase 0.0413 0.1155 0.1197
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0191 0.0341 0.031
Echinococcus multilocularis casein kinase I alpha 0.0222 0.0455 0.0433
Schistosoma mansoni tyrosine kinase 0.0599 0.1838 0.1872
Echinococcus granulosus expressed protein 0.0121 0.0082 0.0045
Leishmania major protein kinase, putative 0.0196 0.0357 0.0288
Loa Loa (eye worm) hypothetical protein 0.0129 0.0114 0.0094
Brugia malayi serine/threonine kinase 12 0.0296 0.0726 0.0696
Entamoeba histolytica protein kinase domain containing protein 0.0357 0.0951 0.0956
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0181 0.0304 0.0276
Onchocerca volvulus 0.0194 0.0351 0.0267
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0224 0.0461 0.0447
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0207 0.0398 0.0378
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Trypanosoma brucei protein kinase, putative 0.0221 0.0451 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.2726 0.9652 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0285 0.0684 0.0679
Loa Loa (eye worm) hypothetical protein 0.0312 0.0786 0.0767
Echinococcus multilocularis dual specificity 0.0124 0.0093 0.0057
Loa Loa (eye worm) hypothetical protein 0.0194 0.0351 0.0332
Echinococcus multilocularis CDC7 cell division cycle 7 0.0128 0.0108 0.0072
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0191 0.0341 0.0271
Brugia malayi Protein kinase domain containing protein 0.1186 0.3995 0.3976
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0175 0.0283 0.0254
Echinococcus granulosus cGMP dependent protein kinase 1 0.0175 0.0283 0.0254
Echinococcus multilocularis dual specificity protein kinase clk2 0.0196 0.0357 0.0332
Echinococcus granulosus tyrosine protein kinase Lyn 0.0504 0.149 0.151
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0108 0.0072
Trypanosoma brucei cdc2-related kinase 1 0.0285 0.0684 0.0629
Giardia lamblia Kinase, NEK 0.038 0.1034 0.0995
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0221 0.0451 0.0386
Leishmania major protein kinase, putative 0.0136 0.0138 0.0058
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Brugia malayi Protein kinase domain containing protein 0.0207 0.0398 0.0367
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Trichomonas vaginalis AGC family protein kinase 0.0413 0.1155 0.1197
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0124 0.0093 0.0012
Loa Loa (eye worm) AGC/NDR protein kinase 0.0391 0.1076 0.1058
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0181 0.0304 0.0276
Schistosoma mansoni serine/threonine protein kinase 0.0489 0.1435 0.1453
Trichomonas vaginalis STE family protein kinase 0.0224 0.0461 0.0478
Brugia malayi serine/threonine-protein kinase 6 0.0296 0.0726 0.0696
Echinococcus granulosus Glutaredoxin protein 5 0.0347 0.0914 0.0911
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0475 0.1383 0.1355
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0551 0.1664 0.1637
Echinococcus granulosus casein kinase i 0.0222 0.0455 0.0433
Trichomonas vaginalis CAMK family protein kinase 0.2726 0.9652 1
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.0426 0.0403
Entamoeba histolytica protein kinase, putative 0.0738 0.2351 0.2412
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0124 0.0093 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Echinococcus granulosus nervana 2 0.0347 0.0914 0.0911
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Giardia lamblia Kinase, CMGC CDK 0.0285 0.0684 0.0629
Leishmania major protein kinase A catalytic subunit isoform 2 0.0191 0.0341 0.0271
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0248 0.0548 0.0518
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0449 0.129 0.1262
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0129 0.0114 0.0034
Echinococcus granulosus serine:threonine protein kinase 0.0313 0.0789 0.0781
Loa Loa (eye worm) protein kinase domain-containing protein 0.0131 0.0121 0.01
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.2726 0.9652 1
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0207 0.0398 0.0374
Brugia malayi Immunoglobulin I-set domain containing protein 0.0214 0.0426 0.0395
Onchocerca volvulus 0.0427 0.1205 0.1161
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Schistosoma mansoni adapter molecule crk 0.0162 0.0234 0.0204
Trypanosoma cruzi casein kinase, putative 0.0222 0.0455 0.039
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0183 0.031 0.0283
Entamoeba histolytica serine/threonine protein kinase, putative 0.2726 0.9652 1
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0187 0.0154
Trichomonas vaginalis CMGC family protein kinase 0.0204 0.0387 0.0401
Echinococcus multilocularis nervana 2 0.0347 0.0914 0.0911
Trichomonas vaginalis AGC family protein kinase 0.0214 0.0426 0.0441
Plasmodium falciparum serine/threonine protein kinase 0.0121 0.0082 0.0075
Schistosoma mansoni protein kinase 0.0136 0.0138 0.0103
Echinococcus multilocularis tyrosine protein kinase Srms 0.036 0.0963 0.0961
Entamoeba histolytica protein kinase, putative 0.0138 0.0147 0.0121
Brugia malayi Protein kinase domain containing protein 0.046 0.133 0.1302
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0599 0.1838 0.1872
Schistosoma mansoni protein kinase 0.0324 0.083 0.0823
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0509 0.1509 0.1492
Brugia malayi Protein kinase domain containing protein 0.0578 0.1761 0.1735
Echinococcus granulosus tyrosine protein kinase shark 0.0183 0.031 0.0283
Loa Loa (eye worm) hypothetical protein 0.0313 0.0789 0.077
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0437 0.1243 0.1253
Brugia malayi Egg laying defective protein 4 0.0175 0.0283 0.0251
Loa Loa (eye worm) hypothetical protein 0.0136 0.0138 0.0118
Loa Loa (eye worm) AUR protein kinase 0.0296 0.0726 0.0707
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0082 0.0045
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0136 0.0138 0.0103
Echinococcus multilocularis serine:threonine protein kinase 3 0.0745 0.2377 0.2432
Trichomonas vaginalis CMGC family protein kinase 0.0285 0.0684 0.0709
Entamoeba histolytica protein kinase domain containing protein 0.0338 0.0879 0.0882
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0214 0.0426 0.0406
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.0684 0.0671
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.2726 0.9652 0.9651
Loa Loa (eye worm) hypothetical protein 0.0423 0.1193 0.1175
Plasmodium falciparum protein serine/threonine kinase-1 0.0196 0.0357 0.2607
Brugia malayi Immunoglobulin I-set domain containing protein 0.0109 0.0038 0.0006
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0285 0.0684 0.0671
Giardia lamblia Kinase, AGC PKA 0.0191 0.0341 0.0271
Schistosoma mansoni protein kinase 0.0433 0.1228 0.1237
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0257 0.0583 0.0567
Brugia malayi Immunoglobulin I-set domain containing protein 0.0644 0.2003 0.1977
Brugia malayi GTP-binding protein, identical 0.014 0.0152 0.012
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0149 0.0187 0.011
Entamoeba histolytica protein kinase, putative 0.0296 0.0726 0.0722
Echinococcus granulosus N chimaerin 0.0181 0.0304 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0162 0.0234 0.0215
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0343 0.09 0.0882
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Echinococcus granulosus mitogen activated protein kinase 3 0.0221 0.0451 0.0429
Trypanosoma cruzi casein kinase II, putative 0.0204 0.0387 0.0319
Brugia malayi Protein kinase domain containing protein 0.0196 0.0357 0.0326
Brugia malayi Hr1 repeat family protein 0.0529 0.1582 0.1555
Loa Loa (eye worm) hypothetical protein 0.0363 0.0974 0.0955
Loa Loa (eye worm) hypothetical protein 0.0257 0.0583 0.0564
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Echinococcus granulosus tyrosine protein kinase Src42A 0.0437 0.1243 0.1253
Trichomonas vaginalis AGC family protein kinase 0.0757 0.242 0.2508
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0437 0.1243 0.1253
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Trichomonas vaginalis STE family protein kinase 0.0212 0.0419 0.0434
Echinococcus granulosus casein kinase I gamma 0.0131 0.0121 0.0085
Brugia malayi Stress-activated protein kinase jnk-1 0.0768 0.246 0.2435
Echinococcus multilocularis mitogen activated protein kinase 14 0.0449 0.129 0.1302
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Echinococcus multilocularis tyrosine protein kinase HCK 0.0275 0.0648 0.0634
Trichomonas vaginalis STE family protein kinase 0.038 0.1034 0.1071
Echinococcus granulosus protein kinase c iota type 0.0655 0.2045 0.2087
Brugia malayi Cam kinase protein 1 0.0136 0.0138 0.0106
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0182 0.0307 0.028
Echinococcus granulosus serine:threonine protein kinase N2 0.0138 0.0145 0.0111
Loa Loa (eye worm) hypothetical protein 0.0214 0.0426 0.0407
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0542 0.1628 0.1654
Loa Loa (eye worm) thyroid receptor interactor 0.0153 0.02 0.018
Echinococcus granulosus tyrosine protein kinase ABL1 0.0811 0.2618 0.2683
Brugia malayi casein kinase 1, delta 0.0222 0.0455 0.0424
Trichomonas vaginalis CMGC family protein kinase 0.0204 0.0387 0.0401
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0475 0.1383 0.1366
Brugia malayi protein-tyrosine kinase 0.036 0.0963 0.0933
Trypanosoma brucei polo-like protein kinase 0.2726 0.9652 1
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0383 0.1046 0.1028
Echinococcus multilocularis casein kinase ii subunit alpha 0.0204 0.0387 0.0363
Echinococcus granulosus serine:threonine protein kinase N2 0.0529 0.1582 0.1606
Trichomonas vaginalis AGC family protein kinase 0.0296 0.0726 0.0752
Loa Loa (eye worm) hypothetical protein 0.0214 0.0426 0.0407
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0093 0.0096
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0408 0.1138 0.1144
Brugia malayi intracellular kinase 0.0357 0.0951 0.0922
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0124 0.0093 0.0073
Trypanosoma cruzi cdc2-related kinase 3 0.0285 0.0684 0.0629
Brugia malayi ephrin receptor 1 precursor 0.0188 0.0331 0.03
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0338 0.0879 0.0833
Entamoeba histolytica protein kinase 2, putative 0.0414 0.1161 0.1175
Giardia lamblia Kinase, CMGC CDK 0.0285 0.0684 0.0629
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0345 0.0906 0.0903
Brugia malayi C1-like domain containing protein 0.0475 0.1383 0.1355
Echinococcus multilocularis NCK adaptor protein 0.0162 0.0234 0.0204
Entamoeba histolytica protein kinase, putative 0.0357 0.0951 0.0956
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0254 0.057 0.0553
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0357 0.0951 0.0949
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0155 0.0207 0.0175
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0341 0.0891 0.0846
Echinococcus granulosus serine:threonine kinase SAD 1 0.0149 0.0187 0.0154
Onchocerca volvulus 0.0128 0.0108 0.0013
Brugia malayi GTP-binding protein 0.014 0.0152 0.012
Echinococcus multilocularis casein kinase I delta 0.0222 0.0455 0.0433
Trypanosoma brucei protein kinase, putative 0.0357 0.0951 0.0908
Schistosoma mansoni protein kinase 0.0296 0.0726 0.0715
Schistosoma mansoni serine/threonine protein kinase 0.0768 0.246 0.2518
Leishmania major protein kinase A catalytic subunit isoform 1 0.0191 0.0341 0.0271
Trypanosoma cruzi cdc2-related kinase 1 0.0285 0.0684 0.0629
Schistosoma mansoni tyrosine kinase 0.1186 0.3995 0.4116
Schistosoma mansoni protein kinase 0.0212 0.0419 0.0396
Echinococcus multilocularis tyrosine protein kinase Fyn 0.036 0.0963 0.0961
Brugia malayi Protein kinase domain containing protein 0.0433 0.1228 0.1199
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0108 0.0035 0.0036
Schistosoma mansoni atypical protein kinase C 0.0667 0.209 0.2134
Loa Loa (eye worm) hypothetical protein 0.0203 0.0383 0.0363
Giardia lamblia Kinase, CAMK CAMKL 0.0149 0.0187 0.011
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0268 0.0625 0.061
Echinococcus multilocularis myosin iiia 0.0224 0.0461 0.044
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0196 0.0357 0.1245
Echinococcus granulosus cyclin dependent kinase 1 0.0285 0.0684 0.0671
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0121 0.0082 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0296 0.0726 0.0752
Entamoeba histolytica protein kinase, putative 0.0147 0.0177 0.0152
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0155 0.0208 0.0132
Loa Loa (eye worm) hypothetical protein 0.0312 0.0786 0.0767
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0307 0.028
Trichomonas vaginalis CMGC family protein kinase 0.0204 0.0387 0.0401
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0558 0.1688 0.1716
Echinococcus granulosus cyclin dependent kinase 0.0285 0.0684 0.0671
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0093 0.0096
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0196 0.0357 0.0288
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0197 0.0361 0.0335
Plasmodium falciparum protein kinase 5 0.0285 0.0684 0.5611
Loa Loa (eye worm) hypothetical protein 0.0516 0.1533 0.1516
Onchocerca volvulus 0.0183 0.031 0.0224
Brugia malayi SRC-1 0.0437 0.1243 0.1215
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0196 0.0357 0.0338
Brugia malayi serine/threonine-protein kinase plk-2 0.2726 0.9652 0.9651
Schistosoma mansoni serine/threonine protein kinase 0.0551 0.1664 0.1691
Echinococcus granulosus rho-associated protein kinase 1 0.0952 0.3137 0.3223
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0191 0.0341 0.0315
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0285 0.0684 0.268
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0176 0.0285 0.0266
Trichomonas vaginalis CMGC family protein kinase 0.0221 0.0451 0.0467
Schistosoma mansoni tyrosine kinase 0.0193 0.0349 0.0323
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Echinococcus multilocularis cyclin dependent kinase 5 0.0285 0.0684 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.0172 0.0178
Plasmodium vivax unspecified product 0.0204 0.0387 0.2883
Trichomonas vaginalis CMGC family protein kinase 0.0204 0.0387 0.0401
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0182 0.0307 0.028
Echinococcus granulosus ephrin type A receptor 4 A 0.0291 0.0708 0.0696
Brugia malayi putative serine/threonine kinase SADA gamma 0.0149 0.0187 0.0155
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0357 0.0951 0.0932
Plasmodium falciparum calcium-dependent protein kinase 1 0.0136 0.0138 0.059
Brugia malayi hypothetical protein 0.0129 0.0114 0.0082
Giardia lamblia Kinase, AGC AKT 0.0322 0.0822 0.0773
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0109 0.0038 0.0018
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0738 0.2351 0.2335
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0357 0.0332
Loa Loa (eye worm) hypothetical protein 0.0191 0.0341 0.0321
Loa Loa (eye worm) hypothetical protein 0.0337 0.0878 0.0859
Onchocerca volvulus 0.0222 0.0455 0.0376
Brugia malayi Protein kinase domain containing protein 0.0642 0.1996 0.197
Brugia malayi Protein kinase domain containing protein 0.0576 0.1753 0.1726
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0437 0.1243 0.1253
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0414 0.1161 0.1168
Giardia lamblia Kinase, CMGC DYRK 0.0124 0.0093 0.0012
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.039 0.1073 0.1076
Echinococcus multilocularis cyclin dependent kinase 0.0285 0.0684 0.0671
Entamoeba histolytica protein kinase domain containing protein 0.0124 0.0093 0.0064
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0193 0.0346 0.0327
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0224 0.0461 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.1649 0.5696 0.5682
Echinococcus granulosus NCK adaptor protein 0.0162 0.0234 0.0204
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0124 0.0093 0.0012
Brugia malayi Protein kinase domain containing protein 0.0183 0.031 0.0279
Echinococcus multilocularis insulin receptor 0.1186 0.3995 0.4116
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0433 0.1231 0.12
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.112 0.3751 0.3861
Echinococcus granulosus ras gtpase 0.014 0.0152 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0646 0.2012 0.2052
Entamoeba histolytica protein kinase, putative 0.0124 0.0093 0.0064
Echinococcus granulosus casein kinase I alpha 0.0222 0.0455 0.0433
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0357 0.0951 0.3852
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0133 0.0127 0.0107
Plasmodium falciparum cGMP-dependent protein kinase 0.0175 0.0283 0.1924
Loa Loa (eye worm) hypothetical protein 0.0129 0.0114 0.0094
Schistosoma mansoni tyrosine kinase 0.0635 0.1972 0.2011
Echinococcus granulosus protein kinase 0.0195 0.0355 0.0329
Brugia malayi Protein kinase domain containing protein 0.067 0.21 0.2075
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0296 0.0726 0.0722
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Brugia malayi Protein kinase domain containing protein 0.0509 0.1509 0.1481
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0149 0.0187 0.0154
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0133 0.0127 0.0095
Brugia malayi Tyrosine-protein kinase abl-1 0.0388 0.1064 0.1035
Onchocerca volvulus 0.0312 0.0786 0.0722
Entamoeba histolytica protein kinase domain containing protein 0.0204 0.0387 0.037
Schistosoma mansoni protein kinase 0.0164 0.0242 0.0212
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0164 0.0242 0.0168
Brugia malayi Protein kinase domain 0.0212 0.0419 0.0388
Trichomonas vaginalis AGC family protein kinase 0.0757 0.242 0.2508
Brugia malayi Immunoglobulin I-set domain containing protein 0.0124 0.0096 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.0391 0.1076 0.1079
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0136 0.0138 0.0282
Brugia malayi map kinase activated protein kinase protein 2 0.0982 0.3244 0.3222
Brugia malayi SH2 domain containing protein 0.0183 0.031 0.0279
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0181 0.0304 0.0284
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0214 0.0426 0.0403
Echinococcus multilocularis mitogen activated protein kinase 14 0.0449 0.129 0.1302
Echinococcus multilocularis raf serine:threonine protein kinase 0.0192 0.0346 0.0319
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Leishmania major casein kinase, putative 0.0222 0.0455 0.039
Entamoeba histolytica protein kinase, putative 0.0212 0.0419 0.0403
Brugia malayi SH2 domain containing protein 0.0183 0.031 0.0279
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0345 0.0906 0.0903
Schistosoma mansoni hypothetical protein 0.0129 0.0114 0.0078
Brugia malayi Protein kinase c protein 2 0.0246 0.0541 0.0511
Brugia malayi Variant SH3 domain containing protein 0.0162 0.0234 0.0203
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0357 0.0332
Giardia lamblia Kinase, AGC PKA 0.0414 0.1161 0.1128
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.067 0.21 0.2084
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0149 0.0187 0.011
Echinococcus multilocularis Immunoglobulin 0.0202 0.0381 0.0356
Giardia lamblia Aurora kinase 0.0296 0.0726 0.0673
Schistosoma mansoni vav2 0.02 0.0373 0.0348
Schistosoma mansoni cell polarity protein 0.014 0.0152 0.0118
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0191 0.0341 0.0271
Echinococcus multilocularis casein kinase I alpha 0.0222 0.0455 0.0433
Echinococcus granulosus mitogen activated protein kinase 11 0.0449 0.129 0.1302
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0221 0.0451 0.0386
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0136 0.0138 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.1307 0.4441 0.4601
Entamoeba histolytica protein kinase, putative 0.0182 0.0307 0.0287
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0437 0.1243 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.039 0.1073 0.1076
Echinococcus multilocularis c src tyrosine kinase 0.0259 0.0591 0.0575
Leishmania major casein kinase II, putative 0.0204 0.0387 0.0319
Loa Loa (eye worm) hypothetical protein 0.0491 0.1441 0.1423
Loa Loa (eye worm) TK/EGFR protein kinase 0.175 0.6067 0.6059
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0248 0.0548 0.053
Trypanosoma brucei casein kinase I, isoform 2 0.0222 0.0455 0.039
Schistosoma mansoni serine/threonine protein kinase 0.0542 0.1628 0.1654
Loa Loa (eye worm) AGC/PKN protein kinase 0.0529 0.1582 0.1565
Echinococcus granulosus aurora kinase A 0.0296 0.0726 0.0715
Trypanosoma cruzi Protein kinase B 0.0433 0.1231 0.12
Echinococcus granulosus dual specificity 0.0124 0.0093 0.0057
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0237 0.051 0.0491
Echinococcus multilocularis serine:threonine protein kinase N2 0.0391 0.1076 0.1079
Loa Loa (eye worm) SRC-1 0.0437 0.1243 0.1226
Loa Loa (eye worm) hypothetical protein 0.0145 0.0172 0.0152
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0347 0.0914 0.0911
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0391 0.1076 0.1079
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0212 0.0419 0.0396
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0164 0.0242 0.0742
Echinococcus granulosus c-Jun N-terminal kinases 0.0768 0.246 0.2518
Plasmodium vivax casein kinase 1, putative 0.0222 0.0455 0.3506
Trichomonas vaginalis AGC family protein kinase 0.0296 0.0726 0.0752
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0191 0.0341 0.1175
Loa Loa (eye worm) hypothetical protein 0.0176 0.0285 0.0265
Brugia malayi Protein kinase domain containing protein 0.0183 0.031 0.0279
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0191 0.0341 0.0315
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0414 0.1161 0.1168
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0149 0.0187 0.011
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0296 0.0726 0.0715
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0449 0.129 0.1272
Loa Loa (eye worm) TK/FAK protein kinase 0.0642 0.1996 0.1979
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0191 0.0341 0.0315
Echinococcus granulosus casein kinase I delta 0.0222 0.0455 0.0433
Entamoeba histolytica protein kinase, putative 0.0757 0.242 0.2484
Loa Loa (eye worm) CAMK protein kinase 0.0124 0.0096 0.0076
Echinococcus multilocularis growth factor receptor bound protein 2 0.0162 0.0234 0.0204
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0164 0.0242 0.0168
Echinococcus granulosus mitogen activated protein kinase 0.0221 0.0451 0.0429
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0357 0.0951 0.0949
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0768 0.246 0.2444
Loa Loa (eye worm) CAMK/PKD protein kinase 0.038 0.1033 0.1015
Schistosoma mansoni tyrosine kinase 0.0725 0.2303 0.2356
Brugia malayi Protein kinase domain containing protein 0.0121 0.0082 0.005
Echinococcus multilocularis casein kinase I delta 0.0222 0.0455 0.0433
Echinococcus multilocularis tyrosine kinase 0.0183 0.031 0.0283
Giardia lamblia Kinase, PLK 0.2726 0.9652 1
Echinococcus granulosus dual specificity 0.0124 0.0093 0.0057
Echinococcus multilocularis twitchin 0.0112 0.005 0.0012
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0212 0.0419 0.0396
Brugia malayi Serine/threonine-protein kinase SULU 0.0268 0.0625 0.0595
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0108 0.0035 0.0036
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0196 0.0357 0.0288
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0142 0.016 0.0126
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0124 0.0093 0.0085
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0093 0.0096
Entamoeba histolytica protein kinase, putative 0.0275 0.0648 0.0641
Trichomonas vaginalis CAMK family protein kinase 0.1307 0.4441 0.4601
Onchocerca volvulus 0.1299 0.4408 0.4513
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0437 0.1243 0.1253
Entamoeba histolytica PH domain containing protein kinase, putative 0.0433 0.1231 0.1247
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0187 0.0154
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0433 0.1228 0.1237
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0599 0.1838 0.1872
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0406 0.1131 0.1136
Trichomonas vaginalis STE family protein kinase 0.0212 0.0419 0.0434
Schistosoma mansoni ste20-related kinase 0.0589 0.1802 0.1834
Trichomonas vaginalis AGC family protein kinase 0.0757 0.242 0.2508
Entamoeba histolytica protein kinase, putative 0.0338 0.0879 0.0882
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0345 0.0906 0.0888
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0197 0.0361 0.0335
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0551 0.1664 0.1647
Toxoplasma gondii AGC kinase 0.0738 0.2351 1
Echinococcus granulosus nervana 2 0.0347 0.0914 0.0911
Echinococcus multilocularis activin receptor type 0.0164 0.0242 0.0212
Echinococcus multilocularis mitogen activated protein kinase 11 0.0449 0.129 0.1302
Schistosoma mansoni vam6/vps39 related 0.0129 0.0114 0.0078
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0191 0.0341 0.0271
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0212 0.0419 0.0396
Schistosoma mansoni tyrosine kinase 0.175 0.6067 0.6271
Trichomonas vaginalis CAMK family protein kinase 0.0155 0.0207 0.0214
Echinococcus multilocularis protein kinase shaggy 0.0357 0.0951 0.0949
Onchocerca volvulus 0.0183 0.031 0.0224
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0285 0.0684 0.0665
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0449 0.129 0.1262
Schistosoma mansoni hypothetical protein 0.0229 0.0478 0.0458
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0108 0.0112
Loa Loa (eye worm) hypothetical protein 0.067 0.21 0.2084
Trypanosoma brucei aurora B kinase 0.0296 0.0726 0.0673
Loa Loa (eye worm) AUR protein kinase 0.0296 0.0726 0.0707
Echinococcus multilocularis ras gtpase 0.014 0.0152 0.0118
Giardia lamblia Kinase, CAMK CAMKL 0.0149 0.0187 0.011
Trichomonas vaginalis STE family protein kinase 0.0212 0.0419 0.0434
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0338 0.0879 0.0833
Trypanosoma brucei Casein kinase II 0.0204 0.0387 0.0319
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0296 0.0726 0.0722
Brugia malayi hypothetical protein 0.0183 0.031 0.0279
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0635 0.1973 0.2012
Loa Loa (eye worm) hypothetical protein 0.027 0.0632 0.0613
Entamoeba histolytica protein kinase, putative 0.0136 0.0138 0.0111
Brugia malayi Immunoglobulin I-set domain containing protein 0.0109 0.0038 0.0006
Loa Loa (eye worm) hypothetical protein 0.0202 0.0381 0.0361
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0391 0.1076 0.1079
Schistosoma mansoni protein kinase 0.0212 0.0419 0.0396
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0221 0.0451 0.0386
Trichomonas vaginalis CMGC family protein kinase 0.0357 0.0951 0.0985
Echinococcus granulosus defective proboscis extension response 0.0202 0.0381 0.0356
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0124 0.0093 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0489 0.1435 0.1418
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0221 0.0451 0.0386
Loa Loa (eye worm) TK/FER protein kinase 0.0183 0.031 0.029
Echinococcus multilocularis cyclin dependent kinase 1 0.0285 0.0684 0.0671
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0221 0.0451 0.0386
Brugia malayi hypothetical protein 0.0214 0.0426 0.0395
Echinococcus granulosus neuroglian 0.0247 0.0545 0.0527
Echinococcus multilocularis 0.0195 0.0355 0.0329
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0455 0.0433
Echinococcus granulosus cGMP dependent protein kinase 0.0175 0.0283 0.0254
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0248 0.0548 0.053
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0149 0.0187 0.011
Onchocerca volvulus 0.0885 0.289 0.2924
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.038 0.1034 0.4217
Brugia malayi casein kinase I 0.0222 0.0455 0.0424
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1199 0.4041 0.4163
Brugia malayi serine/threonine-protein kinase PAK 7 0.0488 0.143 0.1402
Plasmodium falciparum NIMA related kinase 1 0.038 0.1034 0.883
Onchocerca volvulus 0.0129 0.0114 0.0019
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0149 0.0187 0.104
Giardia lamblia Kinase, STE STE20 0.0212 0.0419 0.0352
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0248 0.0548 0.0529
Schistosoma mansoni protein kinase 0.0195 0.0355 0.0329
Schistosoma mansoni serine/threonine protein kinase 0.0952 0.3137 0.3223
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0175 0.0283 0.0919
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0406 0.1131 0.1136
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0138 0.0103
Brugia malayi Protein kinase domain containing protein 0.0285 0.0684 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.0725 0.0714
Brugia malayi Fes/CIP4 homology domain containing protein 0.0153 0.02 0.0168
Brugia malayi Protein kinase domain containing protein 0.0313 0.0789 0.0759
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0182 0.0307 0.028
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0187 0.0154
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.2726 0.9652 1
Brugia malayi Variant SH3 domain containing protein 0.0181 0.0304 0.0272
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.0398 0.0374
Trichomonas vaginalis CMGC family protein kinase 0.0285 0.0684 0.0709
Brugia malayi Pleckstrin Homology Domain 0.0114 0.0058 0.0026
Brugia malayi Casein kinase II, alpha chain 0.0204 0.0387 0.0356
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.038 0.1034 0.883
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0138 0.0103
Echinococcus granulosus raf serine:threonine protein kinase 0.0192 0.0346 0.0319
Brugia malayi Protein kinase domain containing protein 0.0404 0.1124 0.1095
Schistosoma mansoni tyrosine kinase 0.1022 0.3394 0.3491
Onchocerca volvulus 0.0155 0.0208 0.0117
Echinococcus granulosus CDC7 cell division cycle 7 0.0128 0.0108 0.0072
Brugia malayi probable protein kinase 0.0324 0.083 0.08
Echinococcus granulosus protein kinase c epsilon type 0.0489 0.1435 0.1453
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0576 0.1753 0.1736
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0551 0.1664 0.1647
Entamoeba histolytica protein kinase, putative 0.0165 0.0247 0.0224
Loa Loa (eye worm) hypothetical protein 0.0109 0.0038 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0757 0.242 0.2508
Brugia malayi Tyrosine-protein kinase abl-1 0.0499 0.1473 0.1446
Echinococcus multilocularis mitogen activated protein kinase 0.0221 0.0451 0.0429
Schistosoma mansoni protein kinase 0.0136 0.0138 0.0103
Brugia malayi Immunoglobulin I-set domain containing protein 0.0109 0.0038 0.0006
Schistosoma mansoni tyrosine kinase 0.112 0.3751 0.3861
Schistosoma mansoni serine/threonine kinase 0.0383 0.1046 0.1048
Echinococcus granulosus tyrosine protein kinase Src64B 0.0437 0.1243 0.1253
Loa Loa (eye worm) AGC/PKG protein kinase 0.0175 0.0283 0.0263
Loa Loa (eye worm) AGC/AKT protein kinase 0.0757 0.242 0.2405
Brugia malayi Protein kinase domain containing protein 0.0128 0.0108 0.0076
Brugia malayi p70 ribosomal S6 kinase beta 0.0738 0.2351 0.2326
Brugia malayi STE20-like kinase MST 0.0745 0.2377 0.2352
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0551 0.1664 0.1691
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0191 0.0341 0.0315
Loa Loa (eye worm) hypothetical protein 0.042 0.1183 0.1165
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0129 0.0114 0.0078
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.039 0.1073 0.1076
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0191 0.0341 0.2459
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0221 0.0451 0.0431
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0437 0.1243 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.0131 0.0121 0.0085
Brugia malayi Protein kinase domain containing protein 0.0214 0.0426 0.0395
Giardia lamblia Kinase, NEK 0.038 0.1034 0.0995
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0437 0.1243 0.1253
Echinococcus granulosus serine:threonine protein kinase 0.0313 0.0789 0.0781
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0187 0.0193
Echinococcus granulosus casein kinase I delta 0.0222 0.0455 0.0433
Onchocerca volvulus Serine\/threonine kinase homolog 0.2726 0.9652 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0196 0.0357 0.0288
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0542 0.1628 0.1654
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0035 0.0036
Plasmodium vivax protein kinase Crk2 0.0285 0.0684 0.5611
Brugia malayi Protein kinase domain containing protein 0.0383 0.1046 0.1017
Echinococcus multilocularis expressed protein 0.0121 0.0082 0.0045
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0183 0.031 0.0283
Brugia malayi Protein kinase domain containing protein 0.0183 0.031 0.0279
Schistosoma mansoni serine/threonine protein kinase 0.0576 0.1753 0.1783
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0187 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.057 0.1731 0.1761
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0268 0.0625 0.0606
Loa Loa (eye worm) AUR protein kinase 0.0296 0.0726 0.0707
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0202 0.0381 0.0356
Toxoplasma gondii AGC kinase 0.0191 0.0341 0.1175
Schistosoma mansoni serine/threonine-protein kinase 0.0433 0.1231 0.124
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0982 0.3244 0.3334
Entamoeba histolytica PH domain containing protein kinase, putative 0.021 0.041 0.0394
Echinococcus granulosus twitchin 0.0314 0.0792 0.0784
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0222 0.0455 0.0435
Giardia lamblia Kinase, STE STE20 0.0224 0.0461 0.0396
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0811 0.2618 0.2683
Onchocerca volvulus 0.0183 0.031 0.0224
Loa Loa (eye worm) hypothetical protein 0.0214 0.0426 0.0407
Leishmania major protein kinase, putative 0.0196 0.0357 0.0288
Echinococcus granulosus epidermal growth factor receptor 0.175 0.6067 0.6271
Trypanosoma cruzi casein kinase, putative 0.0222 0.0455 0.039
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0214 0.0426 0.0406
Schistosoma mansoni serine/threonine protein kinase 0.0982 0.3244 0.3334
Entamoeba histolytica casein kinase, putative 0.0204 0.0387 0.037
Echinococcus multilocularis myotubularin protein 13 0.0114 0.0058 0.0021
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0222 0.0455 0.0435
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0982 0.3244 0.3334
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0599 0.1838 0.1872
Schistosoma mansoni serine/threonine protein kinase 0.0542 0.1628 0.1654

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 23.89 uM PUBCHEM_BIOASSAY: Bacterial Growth Inhibition Counterscreen using BacTiter-Glo Measured in Microorganism System Using Plate Reader - 2093-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488938] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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