Detailed information for compound 1515942

Basic information

Technical information
  • TDR Targets ID: 1515942
  • Name: (3S,7Z,9R,13R)-9,13-dimethyl-3-(2-methylsulfa nylethyl)-1,11-dioxa-4-azacyclotetradec-7-ene -2,5,12-trione
  • MW: 343.438 | Formula: C16H25NO5S
  • H donors: 1 H acceptors: 3 LogP: 2.02 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCC[C@@H]1NC(=O)C/C=C\[C@@H](C)COC(=O)[C@@H](COC1=O)C
  • InChi: 1S/C16H25NO5S/c1-11-5-4-6-14(18)17-13(7-8-23-3)16(20)22-10-12(2)15(19)21-9-11/h4-5,11-13H,6-10H2,1-3H3,(H,17,18)/b5-4-/t11-,12-,13+/m1/s1
  • InChiKey: JCMPDFWMPUSKDF-VAFQMXCQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3S,7Z,9R,13R)-9,13-dimethyl-3-[2-(methylthio)ethyl]-1,11-dioxa-4-azacyclotetradec-7-ene-2,5,12-trione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/NDR protein kinase 0.0164 0.1295 0.1295
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0084 0.0398 0.0801
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.1134 0.2375
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0069 0.0237 0.0237
Brugia malayi serine/threonine kinase 12 0.0085 0.041 0.041
Schistosoma mansoni tyrosine kinase 0.0142 0.1057 0.2214
Echinococcus granulosus tyrosine protein kinase Lyn 0.0171 0.1374 0.2767
Entamoeba histolytica protein kinase, putative 0.0294 0.2755 0.7345
Loa Loa (eye worm) hypothetical protein 0.0064 0.018 0.018
Echinococcus granulosus serine:threonine protein kinase N2 0.0294 0.2753 0.5544
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0077 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0096 0.054 0.054
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0079 0.0348 0.0831
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0062 0.0158 0.0158
Trichomonas vaginalis CAMK family protein kinase 0.011 0.069 0.2484
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0248 0.2241 0.4512
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0081 0.0373 0.0752
Trypanosoma brucei protein kinase, putative 0.0124 0.0853 0.2678
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.008 0.0358 0.0845
Echinococcus multilocularis cyclin dependent kinase 5 0.0114 0.0742 0.1495
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0227 0.0474
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0322 0.1149
Echinococcus granulosus rho-associated protein kinase 1 0.0321 0.3063 0.6167
Trichomonas vaginalis CK1 family protein kinase 0.0104 0.0628 0.2261
Brugia malayi Protein kinase domain containing protein 0.0188 0.1575 0.1575
Echinococcus multilocularis protein tyrosine kinase 0.0291 0.2725 0.5488
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0445 0.4451 0.4451
Leishmania major protein kinase, putative 0.0085 0.041 0.1101
Echinococcus multilocularis tyrosine protein kinase 0.0278 0.2576 0.5186
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0124 0.0851 0.1713
Entamoeba histolytica casein kinase, putative 0.0104 0.0628 0.1577
Echinococcus granulosus epidermal growth factor receptor 0.0454 0.4557 0.9176
Entamoeba histolytica protein kinase, putative 0.0118 0.0781 0.1992
Schistosoma mansoni protein kinase 0.0149 0.1128 0.2364
Brugia malayi Protein kinase domain containing protein 0.0363 0.3531 0.3531
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0112 0.0717 0.1501
Trichomonas vaginalis AGC family protein kinase 0.019 0.1594 0.5776
Loa Loa (eye worm) TK/EPH protein kinase 0.0119 0.0796 0.0796
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0334 0.3206 0.3206
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0213 0.1854 0.1854
Brugia malayi P38 map kinase family protein 2 0.0155 0.1196 0.1196
Loa Loa (eye worm) TK protein kinase 0.0278 0.2576 0.2576
Brugia malayi Protein kinase domain containing protein 0.0294 0.2759 0.2759
Echinococcus multilocularis protein kinase c iota type 0.0289 0.2698 0.5432
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0228 0.2016 0.2016
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0068 0.0227 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0628 0.1315
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0114 0.0237
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0188 0.1575 0.1575
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Brugia malayi STE20-like kinase MST 0.0253 0.2295 0.2295
Loa Loa (eye worm) TK/FAK protein kinase 0.0294 0.2759 0.2759
Brugia malayi Egg laying defective protein 4 0.013 0.092 0.092
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0076 0.0317 0.158
Schistosoma mansoni protein kinase 0.043 0.4286 0.8985
Echinococcus multilocularis serine:threonine protein kinase 0.011 0.069 0.1388
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus granulosus protein kinase 0.0149 0.1128 0.2272
Brugia malayi serine/threonine-protein kinase plk-2 0.0266 0.2446 0.2446
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.2241 0.4696
Echinococcus granulosus tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Loa Loa (eye worm) CAMK/PHK protein kinase 0.016 0.1252 0.1252
Echinococcus granulosus cGMP dependent protein kinase 0.013 0.092 0.1852
Toxoplasma gondii casein kinase I 0.0104 0.0628 0.1861
Echinococcus granulosus Vam6:Vps39 protein 0.0112 0.0717 0.1443
Brugia malayi Furin-like cysteine rich region family protein 0.0454 0.4557 0.4557
Echinococcus granulosus casein kinase I alpha 0.0104 0.0628 0.1265
Loa Loa (eye worm) hypothetical protein 0.0303 0.2856 0.2856
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Mycobacterium ulcerans hypothetical protein 0.0102 0.0603 0.5
Echinococcus granulosus insulin receptor 0.0394 0.3876 0.7805
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Echinococcus granulosus serine/threonine protein kinase 0.0158 0.1237 0.2491
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0096 0.0532 0.0532
Giardia lamblia Kinase, CMGC SRPK 0.0079 0.0341 0.08
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.1295 0.2713
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0348 0.1241
Entamoeba histolytica protein kinase, putative 0.0096 0.0539 0.1335
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0212 0.1835 0.3696
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0492 0.099
Trichomonas vaginalis CK1 family protein kinase 0.0104 0.0628 0.2261
Brugia malayi SH2 domain containing protein 0.0235 0.2099 0.2099
Schistosoma mansoni nephrin 0.0069 0.0236 0.0492
Schistosoma mansoni atypical protein kinase C 0.0295 0.2766 0.5797
Loa Loa (eye worm) hypothetical protein 0.0053 0.0057 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0969 0.203
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0051 0.0027 0.0055
Brugia malayi Protein kinase domain containing protein 0.0278 0.2576 0.2576
Onchocerca volvulus 0.0185 0.1537 0.4516
Loa Loa (eye worm) TK protein kinase 0.0096 0.0539 0.0539
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.041 0.0856
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0781 0.1635
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0742 0.1554
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.0742 0.0742
Trichomonas vaginalis STE family protein kinase 0.006 0.013 0.0447
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0315 0.2996 0.6033
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0142 0.1057 0.2129
Brugia malayi protein kinase C II. 0.0207 0.1779 0.1779
Brugia malayi protein-tyrosine kinase 0.012 0.0808 0.0808
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Schistosoma mansoni serine/threonine kinase 0.0164 0.1295 0.2713
Loa Loa (eye worm) hypothetical protein 0.0191 0.1606 0.1606
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.043 0.4286 0.8631
Loa Loa (eye worm) hypothetical protein 0.0055 0.0075 0.0075
Giardia lamblia Aurora kinase 0.0085 0.041 0.1101
Loa Loa (eye worm) hypothetical protein 0.0143 0.1066 0.1066
Plasmodium falciparum serine/threonine protein kinase 0.0079 0.0341 0.1813
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0236 0.2109 0.4246
Echinococcus multilocularis casein kinase I alpha 0.0104 0.0628 0.1265
Loa Loa (eye worm) AUR protein kinase 0.0085 0.041 0.041
Schistosoma mansoni hypothetical protein 0.0102 0.0606 0.1268
Schistosoma mansoni serine/threonine kinase 0.0213 0.1846 0.3869
Entamoeba histolytica protein kinase, putative 0.0079 0.0341 0.0798
Brugia malayi Protein kinase domain containing protein 0.0294 0.2755 0.2755
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Echinococcus granulosus protein tyrosine kinase 0.0291 0.2725 0.5488
Echinococcus multilocularis mitogen activated protein kinase 3 0.0079 0.0348 0.07
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0052 0.004 0.0081
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.0358 0.1392
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Entamoeba histolytica protein kinase, putative 0.0081 0.0373 0.0887
Loa Loa (eye worm) AGC/PKN protein kinase 0.0294 0.2753 0.2753
Echinococcus granulosus serine threonine protein kinase nrc 0.0152 0.1168 0.2351
Brugia malayi Protein kinase domain containing protein 0.0189 0.1585 0.1585
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0079 0.0341 0.0341
Schistosoma mansoni tyrosine kinase 0.0278 0.2577 0.5401
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1685 0.353
Schistosoma mansoni tyrosine kinase 0.0315 0.2996 0.6279
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0096 0.054 0.4393
Schistosoma mansoni serine/threonine protein kinase 0.0349 0.3371 0.7066
Schistosoma mansoni protein kinase 0.0104 0.0628 0.1315
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0158 0.1237 0.5017
Plasmodium falciparum serine/threonine protein kinase, putative 0.0085 0.041 0.2494
Brugia malayi Fibronectin type III domain containing protein 0.0055 0.0075 0.0075
Plasmodium vivax casein kinase 1, putative 0.0104 0.0628 0.5178
Onchocerca volvulus 0.0143 0.1066 0.311
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0062 0.0158 0.0317
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.039 0.384 0.384
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0021 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.1804 0.3781
Echinococcus granulosus cyclin dependent kinase 0.0114 0.0742 0.1495
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0184 0.1525 0.1525
Schistosoma mansoni vav2 0.0072 0.027 0.0563
Giardia lamblia Kinase, NEK 0.0132 0.0937 0.3407
Echinococcus granulosus c-Jun N-terminal kinases 0.026 0.2378 0.4789
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0066 0.02 0.02
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Giardia lamblia Kinase, CMGC CLK 0.0149 0.1134 0.4267
Loa Loa (eye worm) hypothetical protein 0.0121 0.0817 0.0817
Trypanosoma brucei rac serine-threonine kinase, putative 0.0294 0.2755 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0164 0.1295 0.2607
Echinococcus granulosus dual specificity 0.0135 0.0969 0.1951
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Onchocerca volvulus Serine\/threonine kinase homolog 0.016 0.1252 0.3664
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Echinococcus granulosus cyclin dependent kinase 1 0.0114 0.0742 0.1495
Brugia malayi SH2 domain containing protein 0.0061 0.0149 0.0149
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.004 0.004
Brugia malayi RhoGAP domain containing protein 0.0066 0.02 0.02
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Plasmodium falciparum calcium-dependent protein kinase 4 0.0096 0.054 0.3788
Echinococcus multilocularis epidermal growth factor receptor 0.0315 0.2996 0.6033
Trichomonas vaginalis STE family protein kinase 0.0081 0.0373 0.1334
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0111 0.07 0.141
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0149 0.1134 0.4591
Echinococcus multilocularis casein kinase i 0.0104 0.0628 0.1265
Brugia malayi Protein kinase domain containing protein 0.0209 0.1804 0.1804
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0061 0.0149 0.0277
Brugia malayi Protein kinase c protein 2 0.0111 0.0707 0.0707
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0079 0.0348 0.0831
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0349 0.3371 0.3371
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0266 0.2446 0.4925
Echinococcus granulosus nervana 2 0.0124 0.0851 0.1713
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0198 0.1685 0.3393
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0096 0.054 0.4393
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0742 0.2676
Loa Loa (eye worm) hypothetical protein 0.0051 0.0027 0.0027
Echinococcus multilocularis raf serine:threonine protein kinase 0.0079 0.0349 0.0704
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0213 0.1854 0.1854
Onchocerca volvulus 0.0112 0.0717 0.2065
Entamoeba histolytica protein kinase, putative 0.0135 0.0969 0.2502
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.0196 0.0722
Plasmodium falciparum NIMA related kinase 1 0.0132 0.0937 0.7719
Entamoeba histolytica protein kinase, putative 0.006 0.013 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.07 0.2524
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.0742 0.1495
Echinococcus multilocularis activin receptor type 0.0066 0.0196 0.0394
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0068 0.0227 0.0687
Brugia malayi Serine/threonine-protein kinase SULU 0.0218 0.1905 0.1905
Schistosoma mansoni serine/threonine protein kinase 0.013 0.092 0.1926
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Giardia lamblia Kinase, AGC AKT 0.0113 0.0723 0.247
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0149 0.1134 0.3759
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0532 0.1317
Echinococcus granulosus Glutaredoxin protein 5 0.0124 0.0851 0.1713
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0149 0.1134 0.4591
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0236 0.2109 0.4246
Brugia malayi MAP kinase sur-1 0.0079 0.0348 0.0348
Loa Loa (eye worm) TK protein kinase 0.025 0.227 0.227
Loa Loa (eye worm) TK protein kinase 0.0211 0.1829 0.1829
Schistosoma mansoni tyrosine kinase 0.0084 0.0398 0.0832
Onchocerca volvulus 0.0061 0.0149 0.0367
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0066 0.0196 0.0151
Giardia lamblia Kinase, CMGC CDK 0.0114 0.0742 0.2555
Entamoeba histolytica protein kinase, putative 0.0066 0.0199 0.0414
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Leishmania major casein kinase II, putative 0.0096 0.0532 0.1636
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0124 0.0853 0.1718
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0492 0.1029
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.2753 0.577
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0096 0.054 0.1513
Echinococcus granulosus protein kinase c iota type 0.0289 0.2698 0.5432
Onchocerca volvulus 0.0061 0.0149 0.0367
Schistosoma mansoni protein kinase 0.0066 0.0196 0.0408
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0124 0.0853 0.1718
Echinococcus granulosus casein kinase I delta 0.0104 0.0628 0.1265
Echinococcus granulosus casein kinase i 0.0104 0.0628 0.1265
Schistosoma mansoni tyrosine kinase 0.0315 0.2996 0.6279
Echinococcus multilocularis tyrosine protein kinase Srms 0.012 0.0808 0.1627
Schistosoma mansoni tyrosine kinase 0.0291 0.2725 0.5712
Brugia malayi Protein kinase domain containing protein 0.0196 0.1664 0.1664
Brugia malayi SRC-1 0.0142 0.1057 0.1057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0114 0.0114
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0742 0.2676
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0124 0.0853 0.0853
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0198 0.1685 0.3393
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0235 0.2099 0.4226
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0075 0.0075
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0212 0.1835 0.3696
Brugia malayi Protein kinase domain containing protein 0.0079 0.0341 0.0341
Schistosoma mansoni ephrin receptor 0.0102 0.0599 0.1254
Brugia malayi Temporarily assigned gene name protein 59 0.0129 0.0911 0.0911
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0119 0.0792 0.2774
Brugia malayi hypothetical protein 0.0112 0.0717 0.0717
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.012 0.0808 0.1627
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Trypanosoma brucei polo-like protein kinase 0.0266 0.2446 0.8809
Entamoeba histolytica protein kinase, putative 0.0077 0.0322 0.0748
Onchocerca volvulus 0.0293 0.2746 0.8131
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0077 0.0322 0.0322
Echinococcus multilocularis N chimaerin 0.0066 0.02 0.0403
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0135 0.0969 0.3124
Brugia malayi Protein kinase domain containing protein 0.0445 0.4451 0.4451
Brugia malayi probable protein kinase 0.0261 0.2385 0.2385
Leishmania major protein kinase A catalytic subunit 0.0068 0.0227 0.0303
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0077 0.0322 0.0649
Brugia malayi Protein kinase domain containing protein 0.0149 0.1134 0.1134
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.1779 0.3729
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0113 0.0723 0.0723
Echinococcus multilocularis NCK adaptor protein 0.0048 0.0001 0.0002
Brugia malayi phosphoinositide-dependent protein kinase I 0.0077 0.0322 0.0322
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.005 0.0021 0.0021
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0085 0.041 0.0985
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0233 0.2069 0.4165
Plasmodium vivax serine/threonine protein kinase, putative 0.0079 0.0341 0.261
Entamoeba histolytica protein kinase domain containing protein 0.0085 0.041 0.0985
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0096 0.054 0.1513
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0923 0.1932
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0068 0.0227 0.0851
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Loa Loa (eye worm) CAMK protein kinase 0.0058 0.0114 0.0114
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0196 0.1664 0.335
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0124 0.0853 0.0853
Echinococcus multilocularis casein kinase I alpha 0.0104 0.0628 0.1265
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0341 0.0712
Entamoeba histolytica protein kinase, putative 0.0288 0.2686 0.7156
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus multilocularis rho associated protein kinase 0.0321 0.3063 0.6167
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0096 0.054 0.054
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0348 0.0727
Echinococcus multilocularis insulin receptor 0.0394 0.3876 0.7805
Echinococcus multilocularis serine:threonine protein kinase N2 0.013 0.0918 0.1849
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0124 0.0853 0.3433
Echinococcus granulosus dual specificity 0.0118 0.0781 0.1572
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0062 0.0158 0.0565
Echinococcus multilocularis mitogen activated protein kinase 14 0.0155 0.1196 0.2408
Echinococcus granulosus dual specificity 0.0135 0.0969 0.1951
Echinococcus multilocularis c src tyrosine kinase 0.0084 0.0398 0.0801
Loa Loa (eye worm) hypothetical protein 0.0233 0.2069 0.2069
Echinococcus multilocularis Glutaredoxin protein 5 0.0124 0.0851 0.1713
Echinococcus multilocularis dual specificity protein kinase clk2 0.0149 0.1134 0.2284
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0853 0.308
Trichomonas vaginalis AGC family protein kinase 0.0132 0.0937 0.3385
Loa Loa (eye worm) hypothetical protein 0.009 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0139 0.1021 0.1021
Echinococcus granulosus neuroglian 0.0053 0.006 0.012
Giardia lamblia Kinase, CK1 Casein kinase 0.0104 0.0628 0.2056
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0076 0.0311 0.1199
Giardia lamblia Kinase, NEK 0.0132 0.0937 0.3407
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0322 0.1149
Echinococcus granulosus tyrosine protein kinase Srms 0.047 0.4734 0.9532
Echinococcus multilocularis aurora kinase A 0.0085 0.041 0.0825
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.2446 0.5126
Plasmodium falciparum glycogen synthase kinase 3 0.0124 0.0853 0.6887
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0322 0.0674
Trichomonas vaginalis CK1 family protein kinase 0.0104 0.0628 0.2261
Entamoeba histolytica PH domain containing protein kinase, putative 0.0158 0.1237 0.3229
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0104 0.0628 0.0628
Echinococcus granulosus tyrosine protein kinase Src42A 0.0142 0.1057 0.2129
Plasmodium falciparum cGMP-dependent protein kinase 0.013 0.092 0.7547
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0492 0.1029
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0198 0.1685 0.1685
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0061 0.0149 0.0299
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0104 0.0628 0.0628
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0066 0.0196 0.0394
Loa Loa (eye worm) hypothetical protein 0.0112 0.0717 0.0717
Brugia malayi Protein kinase domain containing protein 0.0349 0.3371 0.3371
Brugia malayi serine/threonine protein kinase 6 0.0085 0.041 0.041
Echinococcus granulosus Protein kinase C brain isozyme 0.0246 0.2225 0.4481
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0142 0.1057 0.2129
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0068 0.0227 0.0274
Trypanosoma cruzi polo-like protein kinase, putative 0.0266 0.2446 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.013 0.092 0.1852
Loa Loa (eye worm) hypothetical protein 0.0144 0.1075 0.1075
Loa Loa (eye worm) hypothetical protein 0.0198 0.1679 0.1679
Echinococcus multilocularis nervana 2 0.0124 0.0851 0.1713
Schistosoma mansoni tyrosine kinase 0.0084 0.0398 0.0832
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0827 0.2986
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0198 0.1685 0.1685
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0742 0.1554
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0149 0.1134 0.4591
Plasmodium falciparum casein kinase 1 0.0104 0.0628 0.4658
Brugia malayi Doublecortin family protein 0.0146 0.1102 0.1102
Schistosoma mansoni tyrosine kinase 0.0063 0.0171 0.0356
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Leishmania major protein kinase, putative 0.0066 0.0196 0.0167
Onchocerca volvulus Tyrosine kinase homolog 0.0226 0.1991 0.5875
Entamoeba histolytica protein kinase domain containing protein 0.0066 0.0196 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.2274 0.4766
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0068 0.0227 0.0267
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0062 0.0158 0.0317
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0196 0.1664 0.335
Loa Loa (eye worm) TK/ABL protein kinase 0.0061 0.0149 0.0149
Echinococcus multilocularis myosin iiia 0.008 0.0358 0.0721
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0853 0.308
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.026 0.2378 0.2378
Echinococcus granulosus MAP kinase activated protein kinase 2 0.039 0.384 0.7731
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0348 0.1349
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0196 0.1664 0.1664
Echinococcus multilocularis cyclin dependent kinase 0.0114 0.0742 0.1495
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Entamoeba histolytica protein kinase, putative 0.0085 0.041 0.0985
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0164 0.1295 0.2607
Onchocerca volvulus 0.0061 0.0149 0.0367
Entamoeba histolytica protein kinase domain containing protein 0.0124 0.0853 0.2188
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Echinococcus multilocularis protein kinase shaggy 0.0124 0.0853 0.1718
Entamoeba histolytica hypothetical protein 0.0381 0.3735 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0149 0.0149
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0079 0.0341 0.0724
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Schistosoma mansoni serine/threonine protein kinase 0.039 0.384 0.8048
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0068 0.0227 0.1593
Trichomonas vaginalis STE family protein kinase 0.0081 0.0373 0.1334
Schistosoma mansoni kinase 0.0285 0.2653 0.5561
Loa Loa (eye worm) TK protein kinase 0.012 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.009 0.0464 0.0464
Giardia lamblia Kinase, CMGC GSK 0.0124 0.0853 0.304
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.0196 0.0722
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.0742 0.1495
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Echinococcus granulosus epidermal growth factor receptor 0.0315 0.2996 0.6033
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus multilocularis PAK box P21 Rho binding 0.006 0.013 0.0261
Leishmania major protein kinase, putative 0.0149 0.1134 0.4267
Schistosoma mansoni serine/threonine protein kinase 0.0321 0.3063 0.6419
Schistosoma mansoni ste20-related kinase 0.0201 0.1713 0.359
Entamoeba histolytica p21-activated kinase 0.0088 0.0443 0.1076
Brugia malayi Protein kinase domain containing protein 0.0181 0.1494 0.1494
Schistosoma mansoni protein kinase 0.0261 0.2385 0.4999
Trypanosoma brucei protein kinase, putative 0.0066 0.0196 0.0147
Giardia lamblia Kinase, CMGC MAPK 0.0079 0.0348 0.0831
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Giardia lamblia Kinase, STE STE20 0.0081 0.0373 0.0943
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.0742 0.1887
Loa Loa (eye worm) hypothetical protein 0.0055 0.0075 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0492 0.099
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.0742 0.0742
Echinococcus granulosus calcium activated potassium channel 0.013 0.0923 0.1858
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.07 0.2524
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Schistosoma mansoni serine/threonine protein kinase 0.013 0.092 0.1926
Entamoeba histolytica PH domain containing protein kinase, putative 0.0158 0.1237 0.3229
Schistosoma mansoni protein kinase 0.0096 0.0532 0.1113
Echinococcus multilocularis casein kinase I alpha 0.0104 0.0628 0.1265
Loa Loa (eye worm) hypothetical protein 0.0463 0.4649 0.4649
Loa Loa (eye worm) hypothetical protein 0.0062 0.0158 0.0158
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0062 0.0158 0.0565
Schistosoma mansoni protein kinase 0.0081 0.0373 0.0781
Giardia lamblia Kinase, STE STE20 0.008 0.0358 0.0876
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0142 0.1057 0.2129
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0156 0.1208 0.4371
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0246 0.2225 0.4481
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0827 0.2986
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0114 0.0742 0.0742
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0142 0.1057 0.2129
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0409 0.4052 0.816
Loa Loa (eye worm) protein kinase domain-containing protein 0.0209 0.1804 0.1804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0262 0.2397 0.2397
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0152 0.1168 1
Entamoeba histolytica protein kinase, putative 0.0085 0.041 0.0985
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0349 0.3371 0.6789
Brugia malayi Stress-activated protein kinase jnk-1 0.026 0.2378 0.2378
Loa Loa (eye worm) hypothetical protein 0.0185 0.1537 0.1537
Schistosoma mansoni protein kinase 0.043 0.4286 0.8985
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0068 0.0227 0.0267
Echinococcus granulosus serine:threonine kinase SAD 1 0.0062 0.0158 0.0317
Brugia malayi Protein kinase domain containing protein 0.0118 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0082 0.0376 0.0376
Onchocerca volvulus 0.0191 0.1606 0.4724
Brugia malayi Protein kinase domain containing protein 0.0394 0.3876 0.3876
Schistosoma mansoni ephrin receptor 0.0053 0.0055 0.0113
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Schistosoma mansoni serine/threonine-protein kinase 0.0158 0.1237 0.2592
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Toxoplasma gondii AGC kinase 0.0288 0.2686 1
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.0781 0.1992
Toxoplasma gondii AGC kinase 0.0068 0.0227 0.0274
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0492 0.099
Onchocerca volvulus 0.0058 0.0114 0.0264
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0297 0.0679
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0742 0.2676
Echinococcus granulosus tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Loa Loa (eye worm) hypothetical protein 0.0102 0.0606 0.0606
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0363 0.3531 0.3531
Giardia lamblia Kinase, AGC PKA 0.0152 0.1168 0.4414
Brugia malayi Protein kinase domain containing protein 0.0213 0.1846 0.1846
Entamoeba histolytica casein kinase 1, putative 0.0104 0.0628 0.1577
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Loa Loa (eye worm) hypothetical protein 0.0119 0.0798 0.0798
Brugia malayi serine/threonine-protein kinase PAK 7 0.0228 0.2016 0.2016
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Brugia malayi cell division control protein 2 homolog 0.0114 0.0742 0.0742
Echinococcus granulosus casein kinase I gamma 0.0209 0.1804 0.3633
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0142 0.1057 0.2129
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0112 0.0717 0.2153
Trichomonas vaginalis AGC family protein kinase 0.0085 0.041 0.1466
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0142 0.1057 0.2129
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0062 0.0158 0.0158
Brugia malayi p70 ribosomal S6 kinase beta 0.0288 0.2686 0.2686
Echinococcus multilocularis tyrosine protein kinase Abl 0.0084 0.0398 0.0801
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0266 0.2446 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.013 0.092 0.1852
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0212 0.1835 0.3696
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.1295 0.2713
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0149 0.1134 0.3862
Echinococcus granulosus casein kinase I delta 0.0104 0.0628 0.1265
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0781 0.3135
Schistosoma mansoni protein kinase 0.0188 0.1575 0.3299
Loa Loa (eye worm) AGC/PKG protein kinase 0.013 0.092 0.092
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0149 0.1134 0.4591
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0266 0.2446 0.2446
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0076 0.0317 0.0631
Echinococcus multilocularis mitogen activated protein kinase 11 0.0155 0.1196 0.2408
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.1835 0.3846
Echinococcus multilocularis 0.0149 0.1128 0.2272
Echinococcus granulosus cyclin dependent kinase 5 0.0114 0.0742 0.1495
Echinococcus multilocularis titin 0.0058 0.0114 0.023
Loa Loa (eye worm) hypothetical protein 0.0055 0.0075 0.0075
Schistosoma mansoni tyrosine kinase 0.0394 0.3876 0.8125
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Brugia malayi Protein kinase domain containing protein 0.0057 0.0102 0.0102
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0213 0.1846 0.1846
Entamoeba histolytica protein kinase 2, putative 0.0152 0.1168 0.304
Echinococcus multilocularis casein kinase I delta 0.0104 0.0628 0.1265
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0348 0.1241
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0363 0.3531 0.711
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Plasmodium vivax protein kinase Crk2 0.0114 0.0742 0.6198
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.007 0.0243 0.0243
Schistosoma mansoni protein kinase 0.0066 0.0196 0.0408
Leishmania major protein kinase, putative 0.0096 0.054 0.1672
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Echinococcus granulosus NDR protein kinase 0.0164 0.1295 0.2607
Echinococcus multilocularis rac serine:threonine kinase 0.0158 0.1237 0.2491
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0149 0.1134 0.1134
Giardia lamblia Kinase, PLK 0.0266 0.2446 1
Trichomonas vaginalis STE family protein kinase 0.008 0.0358 0.1279
Echinococcus multilocularis roundabout 2 0.0081 0.0364 0.0734
Schistosoma mansoni hypothetical protein 0.0112 0.0717 0.1501
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Schistosoma mansoni vam6/vps39 related 0.0112 0.0717 0.1501
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0231 0.2049 0.4126
Leishmania major casein kinase, putative 0.0104 0.0628 0.2056
Echinococcus granulosus growth factor receptor bound protein 2 0.0048 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0143 0.1066 0.1066
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.014 0.1035 0.2084
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0058 0.0114 0.0114
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0218 0.1905 0.3836
Echinococcus multilocularis casein kinase ii subunit alpha 0.0096 0.0532 0.1071
Entamoeba histolytica protein kinase domain containing protein 0.0124 0.0853 0.2188
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Plasmodium vivax tyrosine kinase-like protein, putative 0.0076 0.0317 0.2399
Loa Loa (eye worm) TK/EGFR protein kinase 0.0454 0.4557 0.4557
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Schistosoma mansoni titin 0.0058 0.0114 0.0237
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0085 0.041 0.0825
Echinococcus multilocularis mitogen activated protein kinase 0.0079 0.0348 0.07
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.014 0.1034 0.2081
Schistosoma mansoni protein kinase C mu 0.0213 0.1854 0.3884
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0207 0.1779 0.1779
Echinococcus granulosus expressed protein 0.0079 0.0341 0.0686
Entamoeba histolytica protein kinase, putative 0.0164 0.1295 0.3385
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.1835 0.3846
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0164 0.1295 0.2607
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Brugia malayi Casein kinase II, alpha chain 0.0096 0.0532 0.0532
Trichomonas vaginalis AGC family protein kinase 0.0085 0.041 0.1466
Schistosoma mansoni cell adhesion molecule 0.0066 0.0203 0.0424
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0923 0.1932
Echinococcus granulosus fibroblast growth factor receptor 4 0.0236 0.2109 0.4246
Schistosoma mansoni protein kinase 0.0085 0.041 0.0856
Loa Loa (eye worm) hypothetical protein 0.0139 0.1021 0.1021
Schistosoma mansoni protein kinase 0.0066 0.0196 0.0408
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.1134 0.2375
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0262 0.2397 0.2397
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Echinococcus granulosus tyrosine protein kinase ABL1 0.0061 0.0149 0.0299
Schistosoma mansoni tyrosine kinase 0.0454 0.4557 0.9552
Brugia malayi Protein kinase domain containing protein 0.0164 0.1295 0.1295
Loa Loa (eye worm) hypothetical protein 0.0068 0.0227 0.0227
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0248 0.2241 0.2241
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0118 0.0781 0.0781
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.014 0.1034 0.2081
Brugia malayi Cam kinase protein 1 0.0096 0.054 0.054
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0492 0.0492
Entamoeba histolytica protein kinase, putative 0.0124 0.0853 0.2188
Brugia malayi Kinase associated domain 1 family protein 0.0102 0.0606 0.0606
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0348 0.1241
Brugia malayi map kinase activated protein kinase protein 2 0.039 0.384 0.384
Loa Loa (eye worm) TK/FER protein kinase 0.0235 0.2099 0.2099
Loa Loa (eye worm) hypothetical protein 0.0086 0.0425 0.0425
Echinococcus granulosus tyrosine protein kinase Src64B 0.0142 0.1057 0.2129
Trichomonas vaginalis AGC family protein kinase 0.0085 0.041 0.1466
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0096 0.054 0.054
Echinococcus multilocularis serine:threonine protein kinase N2 0.0294 0.2753 0.5544
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0124 0.0851 0.1713
Giardia lamblia Kinase, NEK 0.0132 0.0937 0.3407
Leishmania major protein kinase, putative 0.0149 0.1134 0.4267
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0455 0.4562 0.9185
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0096 0.054 0.4393
Echinococcus multilocularis tyrosine protein kinase HCK 0.0096 0.0539 0.1085
Entamoeba histolytica protein kinase, putative 0.0066 0.0199 0.0414
Brugia malayi Hr1 repeat family protein 0.0294 0.2753 0.2753
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0112 0.0717 0.1443
Echinococcus multilocularis mitogen activated protein kinase 11 0.0155 0.1196 0.2408
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0164 0.1295 0.2607
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.013 0.092 0.3015
Onchocerca volvulus 0.0321 0.3063 0.9078
Giardia lamblia Kinase, CMGC CDK 0.0114 0.0742 0.2555
Echinococcus multilocularis cGMP dependent protein kinase 1 0.013 0.092 0.1852
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0079 0.0341 0.0705
Brugia malayi Protein kinase domain 0.0081 0.0373 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0057 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0079 0.0348 0.0752
Brugia malayi Protein kinase domain containing protein 0.016 0.1252 0.1252
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0124 0.0853 0.1787
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.3371 0.3371
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Schistosoma mansoni protein kinase 0.0081 0.0373 0.0781
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0492 0.1029
Entamoeba histolytica protein kinase, putative 0.0079 0.0341 0.0798
Onchocerca volvulus Serine\/threonine kinase homolog 0.0266 0.2446 0.7233
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.008 0.0358 0.0845
Echinococcus granulosus calcium dependent protein kinase 0.0068 0.0223 0.045
Echinococcus multilocularis protein kinase c epsilon type 0.0207 0.1779 0.3583
Echinococcus granulosus mitogen activated protein kinase 11 0.0155 0.1196 0.2408
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0349 0.3371 0.6789
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus granulosus serine:threonine protein kinase 0.011 0.069 0.1388
Entamoeba histolytica protein kinase, putative 0.0294 0.2755 0.7345
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.1134 0.4101
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0135 0.0969 0.3911
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0152 0.1168 0.2351
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0021 0.0041
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0155 0.1196 0.4845
Echinococcus multilocularis dual specificity 0.0135 0.0969 0.1951
Brugia malayi Protein kinase domain containing protein 0.0184 0.1525 0.1525
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0104 0.0628 0.0628
Echinococcus multilocularis ephrin type A receptor 4 A 0.0102 0.0599 0.1206
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0297 0.0679
Entamoeba histolytica casein kinase, putative 0.0096 0.0532 0.1317
Echinococcus multilocularis c Jun NH2 terminal kinase 0.026 0.2378 0.4789
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0066 0.02 0.0417
Echinococcus granulosus protein kinase shaggy 0.0124 0.0853 0.1718
Giardia lamblia Kinase, AGC PKA 0.0068 0.0227 0.0303
Schistosoma mansoni protein kinase 0.006 0.013 0.0269
Plasmodium falciparum protein kinase 5 0.0114 0.0742 0.5788
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.054 0.1941
Echinococcus granulosus titin 0.0058 0.0114 0.023
Loa Loa (eye worm) hypothetical protein 0.0065 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.011 0.069 0.069
Entamoeba histolytica serine/threonine protein kinase, putative 0.0266 0.2446 0.6506
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0781 0.3135
Schistosoma mansoni protein kinase 0.0363 0.3531 0.7401
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.043 0.4286 0.8631
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0114 0.0742 0.1495
Echinococcus granulosus roundabout 2 0.0081 0.0364 0.0734
Echinococcus multilocularis serine:threonine protein kinase 3 0.0253 0.2295 0.462
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0248 0.2241 0.4512
Trichomonas vaginalis AGC family protein kinase 0.0184 0.1525 0.5523
Brugia malayi Tyrosine-protein kinase abl-1 0.0084 0.0398 0.0398
Echinococcus granulosus nervana 2 0.0124 0.0851 0.1713
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.0358 0.1392
Echinococcus multilocularis calcium activated potassium channel 0.013 0.0923 0.1858
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0155 0.1196 0.4845
Plasmodium falciparum calcium-dependent protein kinase 1 0.0096 0.054 0.3788
Brugia malayi protein kinase C3,putative 0.0153 0.118 0.118
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0085 0.041 0.3225
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0171 0.1383 0.1383
Loa Loa (eye worm) hypothetical protein 0.0181 0.1491 0.1491
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.005 0.0021 0.0021
Brugia malayi hypothetical protein 0.0218 0.1905 0.1905
Schistosoma mansoni tyrosine kinase 0.0278 0.2577 0.5401
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Echinococcus multilocularis mitogen activated protein kinase 14 0.0155 0.1196 0.2408
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0079 0.0341 0.08
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.2225 0.4664
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0062 0.0158 0.0158
Echinococcus multilocularis dual specificity 0.0135 0.0969 0.1951
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0235 0.2099 0.4226
Schistosoma mansoni tyrosine kinase 0.0061 0.0149 0.0309
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.016 0.1252 0.252
Loa Loa (eye worm) hypothetical protein 0.0112 0.0717 0.0717
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0124 0.0853 0.304
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0085 0.041 0.0825
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0062 0.0158 0.0317
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0081 0.0373 0.0752
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0084 0.0398 0.0801
Echinococcus multilocularis tyrosine protein kinase Fyn 0.012 0.0808 0.1627
Brugia malayi C1-like domain containing protein 0.0213 0.1854 0.1854
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0102 0.0606 0.1268
Schistosoma mansoni serine/threonine protein kinase 0.016 0.1252 0.2622
Trypanosoma cruzi aurora B kinase, putative 0.0085 0.041 0.1604
Plasmodium vivax serine/threonine kinase-1, putative 0.0149 0.1134 0.97
Plasmodium falciparum calcium-dependent protein kinase 2 0.0096 0.054 0.3788
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0491 0.4966 1
Entamoeba histolytica protein kinase domain containing protein 0.0135 0.0969 0.2502
Echinococcus granulosus serine:threonine protein kinase 0.011 0.069 0.1388
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0491 0.4966 1
Loa Loa (eye worm) casein kinase 0.0181 0.1488 0.1488
Trypanosoma cruzi casein kinase II, putative 0.0096 0.0532 0.2109
Echinococcus multilocularis tyrosine kinase 0.0061 0.0149 0.0299
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0055 0.0076 0.0253
Onchocerca volvulus 0.0174 0.1411 0.4141
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Brugia malayi hypothetical protein 0.0055 0.0075 0.0075
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.0196 0.0147
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0068 0.0227 0.0851
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0135 0.0969 0.321
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0112 0.0717 0.1501
Schistosoma mansoni tyrosine kinase 0.0063 0.0169 0.0352
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0055 0.0076 0.0253
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.039 0.384 0.7731
Echinococcus multilocularis serine:threonine protein kinase 0.011 0.069 0.1388
Echinococcus granulosus serine:threonine protein kinase 3 0.0253 0.2295 0.462
Loa Loa (eye worm) AUR protein kinase 0.0085 0.041 0.041
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0066 0.02 0.0403
Trichomonas vaginalis STE family protein kinase 0.0081 0.0373 0.1334
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0081 0.0373 0.0752
Trypanosoma brucei aurora B kinase 0.0085 0.041 0.097
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0409 0.4052 0.816
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0236 0.2109 0.4246
Loa Loa (eye worm) hypothetical protein 0.0065 0.0188 0.0188
Trypanosoma brucei cdc2-related kinase 3 0.0114 0.0742 0.225
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0142 0.1057 0.2129
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.0742 0.2975
Trypanosoma brucei protein kinase, putative 0.0079 0.0348 0.0732
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0114 0.0742 0.2312
Trichomonas vaginalis AGC family protein kinase 0.0164 0.1295 0.4686
Brugia malayi Immunoglobulin I-set domain containing protein 0.025 0.227 0.227
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.2225 0.4664
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0079 0.0348 0.1349
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0349 0.073
Echinococcus multilocularis casein kinase I delta 0.0104 0.0628 0.1265
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.1905 0.3992
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.1846 0.6693
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0231 0.2049 0.4126
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0155 0.1196 0.3996
Loa Loa (eye worm) hypothetical protein 0.0198 0.1679 0.1679
Echinococcus granulosus tyrosine protein kinase Blk 0.012 0.0808 0.1627
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.005 0.0021 0.0021
Echinococcus multilocularis casein kinase I gamma 0.0209 0.1804 0.3633
Echinococcus multilocularis tyrosine protein kinase shark 0.0061 0.0149 0.0299
Brugia malayi casein kinase I 0.0104 0.0628 0.0628
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0124 0.0853 0.2751
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0923 0.1932
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0077 0.0322 0.0649
Schistosoma mansoni rap gtpase-activating protein 0.0112 0.0717 0.1501
Echinococcus multilocularis expressed conserved protein 0.013 0.092 0.1852
Trypanosoma brucei casein kinase I, isoform 2 0.0104 0.0628 0.1811
Loa Loa (eye worm) hypothetical protein 0.024 0.2157 0.2157
Echinococcus multilocularis expressed protein 0.0079 0.0341 0.0686
Echinococcus multilocularis 0.0128 0.0891 0.1794
Loa Loa (eye worm) AGC/AKT protein kinase 0.0294 0.2755 0.2755
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0096 0.0532 0.4319
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0066 0.02 0.0403
Trichomonas vaginalis STE family protein kinase 0.0081 0.0373 0.1334
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0132 0.0937 0.3084
Echinococcus multilocularis dual specificity 0.0135 0.0969 0.1951
Trichomonas vaginalis STE family protein kinase 0.0132 0.0937 0.3385
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0096 0.054 0.1088
Onchocerca volvulus 0.0104 0.0628 0.18
Giardia lamblia Kinase, CMGC GSK 0.0124 0.0853 0.304
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.3371 0.3371
Entamoeba histolytica serine/threonine protein kinase, putative 0.0062 0.0158 0.0302
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0492 0.099
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.054 0.113
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0079 0.0348 0.1349
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0253 0.2295 0.2295
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0152 0.1168 1
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0159 0.1248 0.1248
Echinococcus multilocularis epidermal growth factor receptor 0.0454 0.4557 0.9176
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0288 0.2686 0.2686
Brugia malayi protein unc-22 0.0058 0.0114 0.0114
Entamoeba histolytica protein kinase, putative 0.0118 0.0781 0.1992
Trichomonas vaginalis AGC family protein kinase 0.0184 0.1525 0.5523
Loa Loa (eye worm) TK/INSR protein kinase 0.0394 0.3876 0.3876
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Echinococcus granulosus dual specificity 0.0135 0.0969 0.1951
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Echinococcus granulosus activin receptor type 0.0066 0.0196 0.0394
Leishmania major protein kinase A catalytic subunit isoform 2 0.0068 0.0227 0.0303
Echinococcus granulosus hypothetical protein 0.0121 0.0817 0.1646
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0096 0.054 0.1513
Echinococcus granulosus casein kinase I alpha 0.0104 0.0628 0.1265
Echinococcus granulosus tyrosine protein kinase shark 0.0061 0.0149 0.0299
Echinococcus granulosus tyrosine protein kinase HCK 0.0096 0.0539 0.1085
Onchocerca volvulus 0.0061 0.0149 0.0367
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0135 0.0969 0.0969
Loa Loa (eye worm) hypothetical protein 0.0139 0.1021 0.1021
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.2049 0.4294
Echinococcus granulosus tyrosine protein kinase Src42A 0.0085 0.0412 0.0829
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0068 0.0227 0.0851
Brugia malayi hypothetical protein 0.0061 0.0149 0.0149
Echinococcus granulosus tyrosine kinase 0.012 0.0808 0.1627
Echinococcus multilocularis calcium dependent protein kinase 0.0068 0.0223 0.045
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0363 0.3531 0.711
Entamoeba histolytica hypothetical protein 0.0118 0.0781 0.1992
Loa Loa (eye worm) thyroid receptor interactor 0.0094 0.0516 0.0516
Giardia lamblia Kinase, CMGC CK2 0.0096 0.0532 0.1636
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.011 0.069 0.069
Brugia malayi Protein kinase domain containing protein 0.011 0.069 0.069
Echinococcus granulosus titin 0.0058 0.0114 0.023
Echinococcus granulosus raf serine:threonine protein kinase 0.0079 0.0349 0.0704
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0079 0.0341 0.132
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0142 0.1057 0.2129
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0155 0.1196 0.4537
Echinococcus granulosus mitogen activated protein kinase 14 0.0155 0.1196 0.2408
Brugia malayi Protein kinase domain containing protein 0.0077 0.0322 0.0322
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0084 0.0398 0.0832
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.0742 0.2975
Echinococcus granulosus serine:threonine protein kinase N2 0.013 0.0918 0.1849
Schistosoma mansoni serine/threonine-protein kinase 0.0158 0.1237 0.2592
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0348 0.1349
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0085 0.0412 0.0829
Leishmania major protein kinase A catalytic subunit isoform 1 0.0068 0.0227 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.1664 0.3487
Plasmodium vivax glycogen synthase kinase 3, putative 0.0124 0.0853 0.719
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0068 0.0227 0.0227
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0079 0.0348 0.0732
Entamoeba histolytica protein kinase, putative 0.0098 0.0554 0.1378
Brugia malayi ephrin receptor 1 precursor 0.0068 0.0218 0.0218
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.008 0.0358 0.0772
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Trichomonas vaginalis AGC family protein kinase 0.0085 0.041 0.1466
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.005 0.0021 0.0051
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0266 0.2446 0.4925
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.0742 0.1887
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0149 0.1128 0.1128
Brugia malayi intracellular kinase 0.0124 0.0853 0.0853
Brugia malayi serine/threonine-protein kinase 6 0.0085 0.041 0.041
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0152 0.1168 0.2351
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0334 0.3206 0.3206
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0227 0.0801
Trypanosoma cruzi Protein kinase B 0.0158 0.1237 0.5017
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Echinococcus granulosus cGMP dependent protein kinase 1 0.013 0.092 0.1852
Plasmodium falciparum calcium-dependent protein kinase 3 0.0096 0.054 0.3788
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0114 0.0742 0.2555
Onchocerca volvulus 0.0076 0.0311 0.0854
Entamoeba histolytica protein kinase , putative 0.0085 0.041 0.0985
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0135 0.0969 0.3546
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0118 0.0781 0.2724
Brugia malayi Protein kinase domain containing protein 0.0114 0.0742 0.0742
Echinococcus multilocularis tyrosine protein kinase Blk 0.012 0.0808 0.1627
Onchocerca volvulus 0.0061 0.0149 0.0367
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0112 0.0717 0.287
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0081 0.0373 0.0752
Brugia malayi putative serine/threonine kinase SADA gamma 0.0062 0.0158 0.0158
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.0742 0.2975
Loa Loa (eye worm) hypothetical protein 0.0112 0.0717 0.0717
Loa Loa (eye worm) SRC-1 0.0142 0.1057 0.1057
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Plasmodium falciparum casein kinase 2, alpha subunit 0.0096 0.0532 0.3707
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0132 0.0937 0.7941
Onchocerca volvulus 0.0124 0.0853 0.2473
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0052 0.004 0.0081
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0149 0.1134 0.3759
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0135 0.0969 0.0969
Echinococcus granulosus casein kinase ii subunit alpha 0.0096 0.0532 0.1071
Echinococcus granulosus phosphorylase kinase gamma subunit 0.016 0.1252 0.252
Plasmodium falciparum calcium-dependent protein kinase 5 0.0096 0.054 0.3788
Onchocerca volvulus 0.0139 0.1021 0.2974
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0227 0.0474
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Trypanosoma brucei cdc2-related kinase 1 0.0114 0.0742 0.225
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0155 0.1196 0.1196
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0096 0.054 0.054
Schistosoma mansoni tyrosine kinase 0.0142 0.1057 0.2214
Schistosoma mansoni tyrosine kinase 0.0069 0.0232 0.0484
Echinococcus granulosus mitogen activated protein kinase 0.0079 0.0348 0.07
Onchocerca volvulus 0.0061 0.0149 0.0367
Giardia lamblia Kinase, CMGC DYRK 0.0135 0.0969 0.3546
Echinococcus granulosus twitchin 0.0082 0.0376 0.0758
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus granulosus ephrin type A receptor 4 A 0.0102 0.0599 0.1206
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0348 0.1241
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0081 0.0373 0.0752
Echinococcus multilocularis serine:threonine protein kinase 38 0.0164 0.1295 0.2607
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0081 0.0373 0.0752
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0212 0.1835 0.3696
Echinococcus granulosus casein kinase I alpha 0.0104 0.0628 0.1265
Schistosoma mansoni protein kinase 0.043 0.4286 0.8985
Echinococcus granulosus tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Loa Loa (eye worm) AUR protein kinase 0.0085 0.041 0.041
Entamoeba histolytica protein kinase, putative 0.0096 0.054 0.1339
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0085 0.041 0.0985
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1685 0.4443
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0068 0.0227 0.0851
Plasmodium vivax unspecified product 0.0096 0.0532 0.4319
Echinococcus multilocularis serine threonine protein kinase 0.0205 0.1755 0.3534
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0218 0.1905 0.1905
Echinococcus multilocularis neuroglian 0.0053 0.006 0.012
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0096 0.054 0.1473
Echinococcus multilocularis hypothetical protein 0.0102 0.0606 0.122
Loa Loa (eye worm) AGC/PKA protein kinase 0.0068 0.0227 0.0227
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0066 0.0196 0.0394
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0062 0.0158 0.0973
Echinococcus multilocularis 0.0121 0.0817 0.1646
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0079 0.0348 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0473 0.4771 1
Onchocerca volvulus 0.0064 0.018 0.0461
Echinococcus multilocularis dual specificity 0.0118 0.0781 0.1572
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0066 0.02 0.0417
Brugia malayi Variant SH3 domain containing protein 0.0066 0.02 0.02
Echinococcus granulosus N chimaerin 0.0066 0.02 0.0403
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0085 0.041 0.0985
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Echinococcus multilocularis nervana 2 0.0124 0.0851 0.1713
Plasmodium vivax calcium-dependent protein kinase, putative 0.0096 0.054 0.4393
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0146 0.1102 0.1102
Schistosoma mansoni tyrosine kinase 0.0394 0.3876 0.8125
Echinococcus granulosus tyrosine protein kinase 0.0278 0.2576 0.5186
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0349 0.3371 1
Echinococcus granulosus aurora kinase A 0.0085 0.041 0.0825
Toxoplasma gondii AGC kinase 0.0068 0.0227 0.0274
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0481 0.1006
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0118 0.0781 0.2399
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Echinococcus granulosus tyrosine kinase 0.0061 0.0149 0.0299
Plasmodium falciparum protein kinase, putative 0.0066 0.0196 0.0378
Brugia malayi casein kinase 1, delta 0.0104 0.0628 0.0628
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0492 0.0492
Echinococcus granulosus dual specificity protein kinase clk2 0.0149 0.1134 0.2284
Echinococcus granulosus protein kinase C gamma type 0.0205 0.1755 0.3534
Schistosoma mansoni tyrosine kinase 0.0236 0.2109 0.4419
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0164 0.1295 0.2607
Brugia malayi Fes/CIP4 homology domain containing protein 0.0094 0.0516 0.0516
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0114 0.0742 0.2555
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0112 0.0717 0.1443
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Plasmodium falciparum protein serine/threonine kinase-1 0.0149 0.1134 0.9667
Echinococcus granulosus c src tyrosine kinase 0.0084 0.0398 0.0801
Trypanosoma cruzi polo-like protein kinase, putative 0.0266 0.2446 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0112 0.0717 0.287
Leishmania major protein kinase, putative 0.008 0.0358 0.0876
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0218 0.1905 0.3836
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0322 0.1149
Trypanosoma brucei Casein kinase II 0.0096 0.0532 0.1441
Echinococcus granulosus mitogen activated protein kinase 3 0.0079 0.0348 0.07
Toxoplasma gondii CMGC kinase, CK2 family 0.0096 0.0532 0.1481
Loa Loa (eye worm) AGC/PKA protein kinase 0.0068 0.0227 0.0227
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.0742 0.2975
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0227 0.0474
Echinococcus granulosus protein kinase c epsilon type 0.0207 0.1779 0.3583
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0341 0.3291 0.3291
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0111 0.07 0.141
Brugia malayi Temporarily assigned gene name protein 59 0.0112 0.0717 0.0717
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0104 0.0628 0.2505
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.014 0.1035 0.2084
Schistosoma mansoni tyrosine kinase 0.0278 0.2577 0.5401
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0152 0.1168 0.4729
Toxoplasma gondii aurora kinase 0.0085 0.041 0.0996
Schistosoma mansoni serine/threonine protein kinase 0.026 0.2378 0.4984
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.2049 0.4294

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.