Detailed information for compound 1527829

Basic information

Technical information
  • TDR Targets ID: 1527829
  • Name: (3S,7Z,9R,13S)-9,13-dimethyl-3-(2-methylsulfa nylethyl)-1,11-dioxa-4-azacyclotetradec-7-ene -2,5,12-trione
  • MW: 343.438 | Formula: C16H25NO5S
  • H donors: 1 H acceptors: 3 LogP: 2.02 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCC[C@@H]1NC(=O)C/C=C\[C@@H](C)COC(=O)[C@H](COC1=O)C
  • InChi: 1S/C16H25NO5S/c1-11-5-4-6-14(18)17-13(7-8-23-3)16(20)22-10-12(2)15(19)21-9-11/h4-5,11-13H,6-10H2,1-3H3,(H,17,18)/b5-4-/t11-,12+,13+/m1/s1
  • InChiKey: JCMPDFWMPUSKDF-PWDGOWMUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3S,7Z,9R,13S)-9,13-dimethyl-3-[2-(methylthio)ethyl]-1,11-dioxa-4-azacyclotetradec-7-ene-2,5,12-trione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi phosphoinositide-dependent protein kinase I 0.0077 0.0322 0.0322
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0085 0.041 0.0825
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.005 0.0021 0.0021
Echinococcus granulosus growth factor receptor bound protein 2 0.0048 0.0001 0.0002
Echinococcus multilocularis cyclin dependent kinase 5 0.0114 0.0742 0.1495
Echinococcus multilocularis protein kinase c epsilon type 0.0207 0.1779 0.3583
Leishmania major protein kinase, putative 0.0149 0.1134 0.4267
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0322 0.1149
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Brugia malayi Immunoglobulin I-set domain containing protein 0.0262 0.2397 0.2397
Brugia malayi Protein kinase domain containing protein 0.0445 0.4451 0.4451
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0135 0.0969 0.0969
Loa Loa (eye worm) AGC/PKN protein kinase 0.0294 0.2753 0.2753
Trypanosoma brucei polo-like protein kinase 0.0266 0.2446 0.8809
Entamoeba histolytica protein kinase, putative 0.0077 0.0322 0.0748
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0077 0.0322 0.0649
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0066 0.0196 0.0394
Loa Loa (eye worm) hypothetical protein 0.0055 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0112 0.0717 0.1501
Echinococcus granulosus tyrosine protein kinase Blk 0.012 0.0808 0.1627
Echinococcus multilocularis tyrosine protein kinase Srms 0.012 0.0808 0.1627
Brugia malayi Kinase associated domain 1 family protein 0.0102 0.0606 0.0606
Echinococcus multilocularis cGMP dependent protein kinase 1 0.013 0.092 0.1852
Echinococcus multilocularis mitogen activated protein kinase 3 0.0079 0.0348 0.07
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0212 0.1835 0.3696
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0132 0.0937 0.7941
Echinococcus multilocularis dual specificity protein kinase clk2 0.0149 0.1134 0.2284
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0124 0.0853 0.304
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0124 0.0853 0.0853
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0969 0.203
Echinococcus multilocularis mitogen activated protein kinase 11 0.0155 0.1196 0.2408
Schistosoma mansoni tyrosine kinase 0.0084 0.0398 0.0832
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0233 0.2069 0.4165
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.0781 0.1992
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0062 0.0158 0.0317
Echinococcus granulosus serine:threonine protein kinase N2 0.013 0.0918 0.1849
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0853 0.308
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0079 0.0341 0.0724
Brugia malayi Protein kinase domain containing protein 0.0394 0.3876 0.3876
Plasmodium falciparum calcium-dependent protein kinase 1 0.0096 0.054 0.3788
Echinococcus multilocularis rho associated protein kinase 0.0321 0.3063 0.6167
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus multilocularis protein kinase c iota type 0.0289 0.2698 0.5432
Echinococcus granulosus casein kinase I alpha 0.0104 0.0628 0.1265
Brugia malayi MAP kinase sur-1 0.0079 0.0348 0.0348
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0058 0.0114 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.1664 0.3487
Trypanosoma brucei protein kinase, putative 0.0124 0.0853 0.2678
Loa Loa (eye worm) AGC/PKA protein kinase 0.0068 0.0227 0.0227
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0079 0.0348 0.0831
Giardia lamblia Aurora kinase 0.0085 0.041 0.1101
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Brugia malayi Egg laying defective protein 4 0.013 0.092 0.092
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0096 0.054 0.1088
Brugia malayi SH2 domain containing protein 0.0235 0.2099 0.2099
Schistosoma mansoni serine/threonine protein kinase 0.013 0.092 0.1926
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Echinococcus multilocularis NCK adaptor protein 0.0048 0.0001 0.0002
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0142 0.1057 0.2129
Trichomonas vaginalis CK1 family protein kinase 0.0104 0.0628 0.2261
Schistosoma mansoni serine/threonine-protein kinase 0.0158 0.1237 0.2592
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0322 0.0674
Trichomonas vaginalis CK1 family protein kinase 0.0104 0.0628 0.2261
Entamoeba histolytica protein kinase domain containing protein 0.0124 0.0853 0.2188
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Schistosoma mansoni serine/threonine protein kinase 0.0473 0.4771 1
Trypanosoma cruzi aurora B kinase, putative 0.0085 0.041 0.1604
Giardia lamblia Kinase, NEK 0.0132 0.0937 0.3407
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0322 0.1149
Plasmodium falciparum casein kinase 1 0.0104 0.0628 0.4658
Onchocerca volvulus 0.0076 0.0311 0.0854
Loa Loa (eye worm) hypothetical protein 0.009 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0053 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0139 0.1021 0.1021
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Brugia malayi Doublecortin family protein 0.0146 0.1102 0.1102
Loa Loa (eye worm) hypothetical protein 0.0064 0.018 0.018
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.0742 0.2975
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0152 0.1168 0.2351
Loa Loa (eye worm) hypothetical protein 0.0198 0.1679 0.1679
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0198 0.1685 0.1685
Brugia malayi Hr1 repeat family protein 0.0294 0.2753 0.2753
Echinococcus granulosus Glutaredoxin protein 5 0.0124 0.0851 0.1713
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0124 0.0853 0.1787
Brugia malayi Tyrosine-protein kinase abl-1 0.0084 0.0398 0.0398
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.2446 0.5126
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0068 0.0227 0.0851
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0146 0.1102 0.1102
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0923 0.1932
Schistosoma mansoni tyrosine kinase 0.0142 0.1057 0.2214
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.2225 0.4664
Brugia malayi Protein kinase domain containing protein 0.0349 0.3371 0.3371
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0085 0.041 0.0985
Plasmodium falciparum protein kinase, putative 0.0066 0.0196 0.0378
Echinococcus granulosus Vam6:Vps39 protein 0.0112 0.0717 0.1443
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Echinococcus multilocularis casein kinase i 0.0104 0.0628 0.1265
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0198 0.1685 0.3393
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0492 0.099
Echinococcus multilocularis tyrosine kinase 0.0061 0.0149 0.0299
Schistosoma mansoni serine/threonine protein kinase 0.039 0.384 0.8048
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0061 0.0149 0.0299
Entamoeba histolytica protein kinase domain containing protein 0.0124 0.0853 0.2188
Echinococcus multilocularis Glutaredoxin protein 5 0.0124 0.0851 0.1713
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Trichomonas vaginalis AGC family protein kinase 0.0085 0.041 0.1466
Echinococcus multilocularis serine:threonine protein kinase N2 0.0164 0.1295 0.2607
Onchocerca volvulus 0.0061 0.0149 0.0367
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0196 0.1664 0.1664
Giardia lamblia Kinase, CMGC CDK 0.0114 0.0742 0.2555
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Echinococcus granulosus raf serine:threonine protein kinase 0.0079 0.0349 0.0704
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.026 0.2378 0.2378
Schistosoma mansoni tyrosine kinase 0.0394 0.3876 0.8125
Giardia lamblia Kinase, CMGC GSK 0.0124 0.0853 0.304
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Trichomonas vaginalis STE family protein kinase 0.008 0.0358 0.1279
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Brugia malayi Protein kinase domain containing protein 0.0196 0.1664 0.1664
Brugia malayi STE20-like kinase MST 0.0253 0.2295 0.2295
Toxoplasma gondii AGC kinase 0.0068 0.0227 0.0274
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Schistosoma mansoni protein kinase 0.0066 0.0196 0.0408
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Echinococcus multilocularis activin receptor type 0.0066 0.0196 0.0394
Brugia malayi serine/threonine-protein kinase PAK 7 0.0228 0.2016 0.2016
Entamoeba histolytica protein kinase domain containing protein 0.0135 0.0969 0.2502
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0923 0.1932
Schistosoma mansoni serine/threonine-protein kinase 0.0158 0.1237 0.2592
Onchocerca volvulus 0.0112 0.0717 0.2065
Echinococcus multilocularis serine:threonine protein kinase N2 0.013 0.0918 0.1849
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Trypanosoma brucei cdc2-related kinase 3 0.0114 0.0742 0.225
Brugia malayi Fes/CIP4 homology domain containing protein 0.0094 0.0516 0.0516
Echinococcus granulosus cyclin dependent kinase 0.0114 0.0742 0.1495
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0348 0.1241
Trichomonas vaginalis STE family protein kinase 0.0081 0.0373 0.1334
Entamoeba histolytica casein kinase, putative 0.0096 0.0532 0.1317
Brugia malayi probable protein kinase 0.0261 0.2385 0.2385
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0184 0.1525 0.1525
Loa Loa (eye worm) hypothetical protein 0.009 0.0464 0.0464
Echinococcus multilocularis N chimaerin 0.0066 0.02 0.0403
Schistosoma mansoni serine/threonine protein kinase 0.0321 0.3063 0.6419
Echinococcus granulosus protein kinase C gamma type 0.0205 0.1755 0.3534
Schistosoma mansoni protein kinase 0.006 0.013 0.0269
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0149 0.1134 0.4591
Schistosoma mansoni tyrosine kinase 0.0315 0.2996 0.6279
Loa Loa (eye worm) AGC/PKA protein kinase 0.0068 0.0227 0.0227
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0062 0.0158 0.0158
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0853 0.308
Leishmania major protein kinase, putative 0.0066 0.0196 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0481 0.1006
Trypanosoma brucei cdc2-related kinase 1 0.0114 0.0742 0.225
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0288 0.2686 0.2686
Brugia malayi protein-tyrosine kinase 0.012 0.0808 0.0808
Echinococcus granulosus calcium dependent protein kinase 0.0068 0.0223 0.045
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.039 0.384 0.7731
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0081 0.0373 0.0752
Brugia malayi Protein kinase domain containing protein 0.0079 0.0341 0.0341
Loa Loa (eye worm) TK/FAK protein kinase 0.0294 0.2759 0.2759
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0062 0.0158 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0057 0.0182
Schistosoma mansoni tyrosine kinase 0.0394 0.3876 0.8125
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0118 0.0781 0.2399
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0084 0.0398 0.0832
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0196 0.1664 0.335
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0062 0.0158 0.0317
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Schistosoma mansoni protein kinase 0.043 0.4286 0.8985
Onchocerca volvulus 0.0185 0.1537 0.4516
Echinococcus granulosus c-Jun N-terminal kinases 0.026 0.2378 0.4789
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0152 0.1168 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0363 0.3531 0.711
Entamoeba histolytica protein kinase , putative 0.0085 0.041 0.0985
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Echinococcus granulosus casein kinase I gamma 0.0209 0.1804 0.3633
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0409 0.4052 0.816
Echinococcus granulosus tyrosine protein kinase Src42A 0.0142 0.1057 0.2129
Plasmodium falciparum protein kinase 5 0.0114 0.0742 0.5788
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0248 0.2241 0.2241
Entamoeba histolytica PH domain containing protein kinase, putative 0.0158 0.1237 0.3229
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0827 0.2986
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Echinococcus multilocularis myosin iiia 0.008 0.0358 0.0721
Brugia malayi Protein kinase domain 0.0081 0.0373 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus granulosus casein kinase I delta 0.0104 0.0628 0.1265
Echinococcus multilocularis tyrosine protein kinase HCK 0.0096 0.0539 0.1085
Echinococcus granulosus tyrosine protein kinase Srms 0.047 0.4734 0.9532
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0084 0.0398 0.0801
Entamoeba histolytica protein kinase, putative 0.0288 0.2686 0.7156
Echinococcus granulosus tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0062 0.0158 0.0973
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Trichomonas vaginalis AGC family protein kinase 0.0085 0.041 0.1466
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0112 0.0717 0.1443
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.0742 0.1887
Entamoeba histolytica protein kinase, putative 0.0294 0.2755 0.7345
Echinococcus multilocularis casein kinase I gamma 0.0209 0.1804 0.3633
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0068 0.0227 0.0687
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0228 0.2016 0.2016
Loa Loa (eye worm) hypothetical protein 0.0119 0.0798 0.0798
Brugia malayi Protein kinase domain containing protein 0.0213 0.1846 0.1846
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0104 0.0628 0.0628
Schistosoma mansoni protein kinase 0.0363 0.3531 0.7401
Schistosoma mansoni hypothetical protein 0.0102 0.0606 0.1268
Brugia malayi protein kinase C3,putative 0.0153 0.118 0.118
Echinococcus granulosus cyclin dependent kinase 5 0.0114 0.0742 0.1495
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0076 0.0311 0.1199
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0142 0.1057 0.2129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0492 0.1029
Echinococcus granulosus titin 0.0058 0.0114 0.023
Giardia lamblia Kinase, AGC PKA 0.0068 0.0227 0.0303
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0118 0.0781 0.0781
Entamoeba histolytica PH domain containing protein kinase, putative 0.0158 0.1237 0.3229
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0068 0.0227 0.1593
Toxoplasma gondii AGC kinase 0.0288 0.2686 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0061 0.0149 0.0299
Schistosoma mansoni kinase 0.0285 0.2653 0.5561
Echinococcus multilocularis aurora kinase A 0.0085 0.041 0.0825
Brugia malayi Furin-like cysteine rich region family protein 0.0454 0.4557 0.4557
Echinococcus granulosus protein tyrosine kinase 0.0291 0.2725 0.5488
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0188 0.1575 0.1575
Echinococcus granulosus casein kinase i 0.0104 0.0628 0.1265
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0077 0.0322 0.0322
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0334 0.3206 0.3206
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0068 0.0227 0.0227
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0081 0.0373 0.0752
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0124 0.0853 0.3433
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.008 0.0358 0.0845
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.0742 0.1887
Echinococcus multilocularis mitogen activated protein kinase 0.0079 0.0348 0.07
Loa Loa (eye worm) hypothetical protein 0.011 0.069 0.069
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0248 0.2241 0.4512
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0322 0.1149
Brugia malayi Casein kinase II, alpha chain 0.0096 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0065 0.0188 0.0188
Echinococcus multilocularis serine:threonine protein kinase N2 0.0294 0.2753 0.5544
Echinococcus granulosus tyrosine protein kinase Lyn 0.0171 0.1374 0.2767
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Leishmania major protein kinase, putative 0.0085 0.041 0.1101
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0142 0.1057 0.2129
Echinococcus multilocularis 0.0149 0.1128 0.2272
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.007 0.0243 0.0243
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0084 0.0398 0.0801
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0164 0.1295 0.2607
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.043 0.4286 0.8631
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0076 0.0317 0.158
Brugia malayi Protein kinase domain containing protein 0.011 0.069 0.069
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0253 0.2295 0.2295
Entamoeba histolytica protein kinase, putative 0.0294 0.2755 0.7345
Echinococcus multilocularis expressed conserved protein 0.013 0.092 0.1852
Brugia malayi Protein kinase domain containing protein 0.0189 0.1585 0.1585
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0062 0.0158 0.0565
Brugia malayi protein unc-22 0.0058 0.0114 0.0114
Echinococcus multilocularis serine:threonine protein kinase 0.011 0.069 0.1388
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0068 0.0227 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.2049 0.4294
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Schistosoma mansoni tyrosine kinase 0.0291 0.2725 0.5712
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0334 0.3206 0.3206
Loa Loa (eye worm) TK/EPH protein kinase 0.0119 0.0796 0.0796
Echinococcus granulosus mitogen activated protein kinase 14 0.0155 0.1196 0.2408
Echinococcus multilocularis tyrosine protein kinase 0.0278 0.2576 0.5186
Schistosoma mansoni atypical protein kinase C 0.0295 0.2766 0.5797
Brugia malayi C1-like domain containing protein 0.0213 0.1854 0.1854
Loa Loa (eye worm) hypothetical protein 0.0112 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0191 0.1606 0.1606
Brugia malayi serine/threonine-protein kinase plk-2 0.0266 0.2446 0.2446
Brugia malayi Protein kinase domain containing protein 0.0363 0.3531 0.3531
Giardia lamblia Kinase, CMGC CLK 0.0149 0.1134 0.4267
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0104 0.0628 0.0628
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0119 0.0792 0.2774
Schistosoma mansoni tyrosine kinase 0.0454 0.4557 0.9552
Echinococcus multilocularis nervana 2 0.0124 0.0851 0.1713
Schistosoma mansoni tyrosine kinase 0.0069 0.0232 0.0484
Loa Loa (eye worm) hypothetical protein 0.0303 0.2856 0.2856
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Loa Loa (eye worm) TK/FER protein kinase 0.0235 0.2099 0.2099
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0212 0.1835 0.3696
Entamoeba histolytica casein kinase, putative 0.0104 0.0628 0.1577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0492 0.1029
Plasmodium falciparum serine/threonine protein kinase 0.0079 0.0341 0.1813
Trichomonas vaginalis CK1 family protein kinase 0.0104 0.0628 0.2261
Echinococcus granulosus casein kinase ii subunit alpha 0.0096 0.0532 0.1071
Entamoeba histolytica protein kinase, putative 0.0164 0.1295 0.3385
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0079 0.0348 0.0732
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0096 0.054 0.1513
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0159 0.1248 0.1248
Echinococcus granulosus insulin receptor 0.0394 0.3876 0.7805
Echinococcus multilocularis casein kinase I alpha 0.0104 0.0628 0.1265
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0062 0.0158 0.0158
Echinococcus granulosus ephrin type A receptor 4 A 0.0102 0.0599 0.1206
Echinococcus granulosus epidermal growth factor receptor 0.0315 0.2996 0.6033
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Brugia malayi Temporarily assigned gene name protein 59 0.0112 0.0717 0.0717
Echinococcus granulosus epidermal growth factor receptor 0.0454 0.4557 0.9176
Schistosoma mansoni protein kinase 0.0104 0.0628 0.1315
Echinococcus granulosus phosphorylase kinase gamma subunit 0.016 0.1252 0.252
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Loa Loa (eye worm) AGC/PKG protein kinase 0.013 0.092 0.092
Brugia malayi SRC-1 0.0142 0.1057 0.1057
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.2241 0.4696
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0149 0.1134 0.4591
Brugia malayi putative serine/threonine kinase SADA gamma 0.0062 0.0158 0.0158
Onchocerca volvulus 0.0293 0.2746 0.8131
Toxoplasma gondii AGC kinase 0.0068 0.0227 0.0274
Echinococcus granulosus serine:threonine protein kinase N2 0.0294 0.2753 0.5544
Echinococcus granulosus mitogen activated protein kinase 0.0079 0.0348 0.07
Entamoeba histolytica protein kinase, putative 0.0085 0.041 0.0985
Echinococcus multilocularis ephrin type A receptor 4 A 0.0102 0.0599 0.1206
Echinococcus granulosus casein kinase I delta 0.0104 0.0628 0.1265
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.1905 0.3992
Loa Loa (eye worm) hypothetical protein 0.024 0.2157 0.2157
Giardia lamblia Kinase, CMGC SRPK 0.0079 0.0341 0.08
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0085 0.041 0.3225
Loa Loa (eye worm) hypothetical protein 0.0144 0.1075 0.1075
Onchocerca volvulus 0.0191 0.1606 0.4724
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.043 0.4286 0.8631
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0055 0.0076 0.0253
Echinococcus multilocularis 0.0121 0.0817 0.1646
Echinococcus granulosus protein kinase c epsilon type 0.0207 0.1779 0.3583
Leishmania major protein kinase A catalytic subunit 0.0068 0.0227 0.0303
Loa Loa (eye worm) AGC/NDR protein kinase 0.0164 0.1295 0.1295
Echinococcus multilocularis epidermal growth factor receptor 0.0315 0.2996 0.6033
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0142 0.1057 0.2129
Leishmania major protein kinase, putative 0.0096 0.054 0.1672
Plasmodium vivax protein kinase Crk2 0.0114 0.0742 0.6198
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0075 0.0075
Entamoeba histolytica protein kinase, putative 0.006 0.013 0.0226
Entamoeba histolytica hypothetical protein 0.0118 0.0781 0.1992
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0781 0.3135
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Trichomonas vaginalis AGC family protein kinase 0.0085 0.041 0.1466
Brugia malayi Protein kinase domain containing protein 0.0188 0.1575 0.1575
Leishmania major casein kinase II, putative 0.0096 0.0532 0.1636
Entamoeba histolytica protein kinase, putative 0.0098 0.0554 0.1378
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0135 0.0969 0.3546
Loa Loa (eye worm) hypothetical protein 0.0051 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase 0.0278 0.2576 0.5186
Schistosoma mansoni serine/threonine protein kinase 0.016 0.1252 0.2622
Giardia lamblia Kinase, CMGC DYRK 0.0135 0.0969 0.3546
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Brugia malayi Protein kinase domain containing protein 0.0294 0.2759 0.2759
Brugia malayi Protein kinase domain containing protein 0.0164 0.1295 0.1295
Schistosoma mansoni protein kinase 0.0261 0.2385 0.4999
Schistosoma mansoni protein kinase 0.0066 0.0196 0.0408
Leishmania major protein kinase, putative 0.0149 0.1134 0.4267
Loa Loa (eye worm) TK protein kinase 0.0096 0.0539 0.0539
Echinococcus granulosus hypothetical protein 0.0121 0.0817 0.1646
Brugia malayi Protein kinase domain containing protein 0.0184 0.1525 0.1525
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0132 0.0937 0.3084
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0297 0.0679
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0742 0.1554
Onchocerca volvulus 0.0143 0.1066 0.311
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.039 0.384 0.384
Loa Loa (eye worm) TK protein kinase 0.0211 0.1829 0.1829
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0062 0.0158 0.0158
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.005 0.0021 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.041 0.0856
Loa Loa (eye worm) hypothetical protein 0.0055 0.0075 0.0075
Plasmodium vivax casein kinase 1, putative 0.0104 0.0628 0.5178
Echinococcus multilocularis rac serine:threonine kinase 0.0158 0.1237 0.2491
Echinococcus multilocularis casein kinase I delta 0.0104 0.0628 0.1265
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0349 0.3371 0.6789
Echinococcus granulosus rho-associated protein kinase 1 0.0321 0.3063 0.6167
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.054 0.1941
Schistosoma mansoni tyrosine kinase 0.0278 0.2577 0.5401
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0348 0.1241
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0198 0.1685 0.1685
Entamoeba histolytica protein kinase 2, putative 0.0152 0.1168 0.304
Trichomonas vaginalis AGC family protein kinase 0.019 0.1594 0.5776
Trichomonas vaginalis STE family protein kinase 0.0081 0.0373 0.1334
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.2753 0.577
Leishmania major protein kinase, putative 0.008 0.0358 0.0876
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.004 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0348 0.1241
Schistosoma mansoni protein kinase 0.0066 0.0196 0.0408
Trichomonas vaginalis STE family protein kinase 0.0132 0.0937 0.3385
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0112 0.0717 0.1501
Echinococcus granulosus dual specificity 0.0135 0.0969 0.1951
Entamoeba histolytica protein kinase, putative 0.0079 0.0341 0.0798
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0052 0.004 0.0081
Schistosoma mansoni protein kinase C mu 0.0213 0.1854 0.3884
Giardia lamblia Kinase, CMGC CDK 0.0114 0.0742 0.2555
Brugia malayi Cam kinase protein 1 0.0096 0.054 0.054
Entamoeba histolytica protein kinase, putative 0.0124 0.0853 0.2188
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.1685 0.4443
Giardia lamblia Kinase, CMGC MAPK 0.0079 0.0348 0.0831
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0349 0.3371 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0266 0.2446 1
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0111 0.07 0.141
Brugia malayi Protein kinase domain containing protein 0.0209 0.1804 0.1804
Echinococcus granulosus tyrosine kinase 0.0061 0.0149 0.0299
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0149 0.1134 0.3759
Giardia lamblia Kinase, CK1 Casein kinase 0.0104 0.0628 0.2056
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0315 0.2996 0.6033
Echinococcus multilocularis casein kinase ii subunit alpha 0.0096 0.0532 0.1071
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0081 0.0373 0.0752
Brugia malayi Protein kinase c protein 2 0.0111 0.0707 0.0707
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0066 0.02 0.02
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0052 0.004 0.0081
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.0742 0.2975
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0061 0.0149 0.0277
Schistosoma mansoni tyrosine kinase 0.0061 0.0149 0.0309
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.0196 0.0147
Brugia malayi Protein kinase domain containing protein 0.0294 0.2755 0.2755
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Echinococcus granulosus protein kinase c iota type 0.0289 0.2698 0.5432
Plasmodium vivax unspecified product 0.0096 0.0532 0.4319
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0492 0.0492
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus granulosus nervana 2 0.0124 0.0851 0.1713
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Schistosoma mansoni cell adhesion molecule 0.0066 0.0203 0.0424
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.0742 0.1495
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0066 0.02 0.0417
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0212 0.1835 0.3696
Echinococcus granulosus aurora kinase A 0.0085 0.041 0.0825
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0236 0.2109 0.4246
Entamoeba histolytica protein kinase, putative 0.0079 0.0341 0.0798
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.2274 0.4766
Plasmodium falciparum calcium-dependent protein kinase 4 0.0096 0.054 0.3788
Echinococcus granulosus nervana 2 0.0124 0.0851 0.1713
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0149 0.1134 0.4591
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0149 0.1128 0.1128
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0218 0.1905 0.3836
Echinococcus multilocularis cGMP dependent protein kinase 1 0.013 0.092 0.1852
Giardia lamblia Kinase, AGC AKT 0.0113 0.0723 0.247
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0227 0.0474
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0068 0.0227 0.0851
Brugia malayi Protein kinase domain containing protein 0.0114 0.0742 0.0742
Entamoeba histolytica protein kinase, putative 0.0066 0.0199 0.0414
Onchocerca volvulus 0.0061 0.0149 0.0367
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.07 0.2524
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Schistosoma mansoni tyrosine kinase 0.0236 0.2109 0.4419
Schistosoma mansoni ste20-related kinase 0.0201 0.1713 0.359
Entamoeba histolytica protein kinase, putative 0.0096 0.054 0.1339
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0742 0.1554
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0124 0.0853 0.2751
Loa Loa (eye worm) CAMK protein kinase 0.0058 0.0114 0.0114
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0142 0.1057 0.2129
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0196 0.1664 0.335
Echinococcus multilocularis protein tyrosine kinase 0.0291 0.2725 0.5488
Toxoplasma gondii casein kinase I 0.0104 0.0628 0.1861
Brugia malayi casein kinase I 0.0104 0.0628 0.0628
Schistosoma mansoni tyrosine kinase 0.0315 0.2996 0.6279
Loa Loa (eye worm) TK protein kinase 0.012 0.0808 0.0808
Echinococcus multilocularis 0.0128 0.0891 0.1794
Loa Loa (eye worm) hypothetical protein 0.0061 0.0149 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.013 0.092 0.1926
Echinococcus multilocularis nervana 2 0.0124 0.0851 0.1713
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0112 0.0717 0.287
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0079 0.0348 0.0752
Loa Loa (eye worm) protein kinase domain-containing protein 0.0209 0.1804 0.1804
Entamoeba histolytica casein kinase 1, putative 0.0104 0.0628 0.1577
Loa Loa (eye worm) TK/ABL protein kinase 0.0061 0.0149 0.0149
Echinococcus multilocularis tyrosine protein kinase Fyn 0.012 0.0808 0.1627
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0051 0.0027 0.0055
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0155 0.1196 0.3996
Loa Loa (eye worm) hypothetical protein 0.0198 0.1679 0.1679
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0213 0.1846 0.1846
Loa Loa (eye worm) hypothetical protein 0.0233 0.2069 0.2069
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0142 0.1057 0.2129
Brugia malayi Serine/threonine-protein kinase SULU 0.0218 0.1905 0.1905
Trypanosoma brucei casein kinase I, isoform 2 0.0104 0.0628 0.1811
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0348 0.1349
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.2225 0.4664
Plasmodium vivax serine/threonine protein kinase, putative 0.0079 0.0341 0.261
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.0742 0.0742
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0164 0.1295 0.2607
Brugia malayi Immunoglobulin I-set domain containing protein 0.025 0.227 0.227
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0079 0.0348 0.1349
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.0742 0.0742
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.0742 0.1495
Loa Loa (eye worm) hypothetical protein 0.0065 0.0188 0.0188
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Echinococcus granulosus tyrosine protein kinase Src64B 0.0142 0.1057 0.2129
Loa Loa (eye worm) TK/INSR protein kinase 0.0394 0.3876 0.3876
Leishmania major protein kinase A catalytic subunit isoform 2 0.0068 0.0227 0.0303
Echinococcus granulosus activin receptor type 0.0066 0.0196 0.0394
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Brugia malayi Fibronectin type III domain containing protein 0.0055 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0185 0.1537 0.1537
Brugia malayi p70 ribosomal S6 kinase beta 0.0288 0.2686 0.2686
Loa Loa (eye worm) TK/EGFR protein kinase 0.0454 0.4557 0.4557
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0114 0.0237
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0118 0.0781 0.2724
Echinococcus multilocularis serine:threonine protein kinase 3 0.0253 0.2295 0.462
Giardia lamblia Kinase, AGC PKA 0.0152 0.1168 0.4414
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.016 0.1252 0.252
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0349 0.3371 0.3371
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0341 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0492 0.1029
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0266 0.2446 0.2446
Giardia lamblia Kinase, NEK 0.0132 0.0937 0.3407
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0096 0.054 0.1473
Plasmodium vivax glycogen synthase kinase 3, putative 0.0124 0.0853 0.719
Loa Loa (eye worm) hypothetical protein 0.0055 0.0075 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Giardia lamblia Kinase, NEK 0.0132 0.0937 0.3407
Echinococcus granulosus dual specificity 0.0135 0.0969 0.1951
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Echinococcus multilocularis roundabout 2 0.0081 0.0364 0.0734
Trypanosoma brucei protein kinase, putative 0.0066 0.0196 0.0147
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0348 0.1349
Brugia malayi Temporarily assigned gene name protein 59 0.0129 0.0911 0.0911
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0246 0.2225 0.4481
Echinococcus multilocularis calcium activated potassium channel 0.013 0.0923 0.1858
Echinococcus multilocularis casein kinase I delta 0.0104 0.0628 0.1265
Giardia lamblia Kinase, STE STE20 0.008 0.0358 0.0876
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0114 0.0114
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0079 0.0341 0.0341
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0111 0.07 0.141
Echinococcus granulosus serine:threonine protein kinase 0.011 0.069 0.1388
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0532 0.1317
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0363 0.3531 0.711
Echinococcus granulosus dual specificity 0.0118 0.0781 0.1572
Loa Loa (eye worm) hypothetical protein 0.0068 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0086 0.0425 0.0425
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0231 0.2049 0.4126
Echinococcus multilocularis tyrosine protein kinase Blk 0.012 0.0808 0.1627
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.014 0.1034 0.2081
Onchocerca volvulus 0.0061 0.0149 0.0367
Echinococcus multilocularis dual specificity 0.0135 0.0969 0.1951
Plasmodium falciparum casein kinase 2, alpha subunit 0.0096 0.0532 0.3707
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0104 0.0628 0.0628
Onchocerca volvulus 0.0061 0.0149 0.0367
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0827 0.2986
Entamoeba histolytica protein kinase, putative 0.0096 0.0539 0.1335
Echinococcus granulosus serine/threonine protein kinase 0.0158 0.1237 0.2491
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0149 0.1134 0.3759
Giardia lamblia Kinase, CMGC GSK 0.0124 0.0853 0.304
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0085 0.041 0.0985
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0227 0.0474
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0152 0.1168 0.2351
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0341 0.3291 0.3291
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0114 0.0742 0.2555
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0021 0.0041
Entamoeba histolytica serine/threonine protein kinase, putative 0.0062 0.0158 0.0302
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0266 0.2446 1
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.008 0.0358 0.0772
Brugia malayi hypothetical protein 0.0061 0.0149 0.0149
Trypanosoma brucei aurora B kinase 0.0085 0.041 0.097
Echinococcus granulosus serine:threonine kinase SAD 1 0.0062 0.0158 0.0317
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0348 0.0727
Schistosoma mansoni ephrin receptor 0.0102 0.0599 0.1254
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0068 0.0227 0.0267
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0068 0.0227 0.0851
Plasmodium falciparum glycogen synthase kinase 3 0.0124 0.0853 0.6887
Plasmodium falciparum serine/threonine protein kinase, putative 0.0085 0.041 0.2494
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0079 0.0341 0.08
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1685 0.353
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Trypanosoma cruzi Protein kinase B 0.0158 0.1237 0.5017
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0742 0.2676
Echinococcus granulosus calcium activated potassium channel 0.013 0.0923 0.1858
Echinococcus granulosus c src tyrosine kinase 0.0084 0.0398 0.0801
Echinococcus multilocularis mitogen activated protein kinase 14 0.0155 0.1196 0.2408
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0077 0.0322 0.0322
Brugia malayi P38 map kinase family protein 2 0.0155 0.1196 0.1196
Echinococcus granulosus tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0068 0.0227 0.0267
Loa Loa (eye worm) hypothetical protein 0.0139 0.1021 0.1021
Onchocerca volvulus Serine\/threonine kinase homolog 0.016 0.1252 0.3664
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0149 0.1134 0.4591
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0096 0.054 0.054
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0135 0.0969 0.3911
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0124 0.0853 0.1718
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0096 0.0532 0.0532
Echinococcus granulosus neuroglian 0.0053 0.006 0.012
Plasmodium falciparum calcium-dependent protein kinase 2 0.0096 0.054 0.3788
Echinococcus granulosus tyrosine protein kinase Fyn 0.0142 0.1057 0.2129
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Plasmodium falciparum NIMA related kinase 1 0.0132 0.0937 0.7719
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0114 0.0742 0.1495
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0112 0.0717 0.1501
Entamoeba histolytica protein kinase, putative 0.0081 0.0373 0.0887
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0062 0.0158 0.0317
Loa Loa (eye worm) hypothetical protein 0.0062 0.0158 0.0158
Echinococcus granulosus cyclin dependent kinase 1 0.0114 0.0742 0.1495
Echinococcus granulosus tyrosine kinase 0.012 0.0808 0.1627
Brugia malayi hypothetical protein 0.0112 0.0717 0.0717
Schistosoma mansoni nephrin 0.0069 0.0236 0.0492
Loa Loa (eye worm) hypothetical protein 0.0143 0.1066 0.1066
Echinococcus multilocularis dual specificity 0.0118 0.0781 0.1572
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0135 0.0969 0.321
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0076 0.0317 0.0631
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0085 0.0412 0.0829
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0742 0.2676
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0096 0.054 0.054
Schistosoma mansoni tyrosine kinase 0.0278 0.2577 0.5401
Trichomonas vaginalis AGC family protein kinase 0.0132 0.0937 0.3385
Schistosoma mansoni hypothetical protein 0.0102 0.0606 0.1268
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.054 0.113
Echinococcus multilocularis neuroglian 0.0053 0.006 0.012
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0218 0.1905 0.1905
Loa Loa (eye worm) AUR protein kinase 0.0085 0.041 0.041
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0198 0.1685 0.3393
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0227 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.1779 0.3729
Schistosoma mansoni protein kinase 0.0085 0.041 0.0856
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0142 0.1057 0.2129
Brugia malayi casein kinase 1, delta 0.0104 0.0628 0.0628
Schistosoma mansoni protein kinase 0.043 0.4286 0.8985
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.1295 0.2713
Schistosoma mansoni protein kinase 0.0081 0.0373 0.0781
Schistosoma mansoni serine/threonine kinase 0.0213 0.1846 0.3869
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0079 0.0348 0.0348
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0081 0.0373 0.0752
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus granulosus mitogen activated protein kinase 3 0.0079 0.0348 0.07
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Echinococcus granulosus twitchin 0.0082 0.0376 0.0758
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0069 0.0237 0.0237
Loa Loa (eye worm) SRC-1 0.0142 0.1057 0.1057
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Echinococcus multilocularis mitogen activated protein kinase 11 0.0155 0.1196 0.2408
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0628 0.1315
Echinococcus multilocularis cyclin dependent kinase 0.0114 0.0742 0.1495
Loa Loa (eye worm) thyroid receptor interactor 0.0094 0.0516 0.0516
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.1295 0.2713
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0236 0.2109 0.4246
Echinococcus multilocularis serine threonine protein kinase 0.0205 0.1755 0.3534
Echinococcus granulosus dual specificity protein kinase clk2 0.0149 0.1134 0.2284
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0492 0.099
Echinococcus multilocularis casein kinase I alpha 0.0104 0.0628 0.1265
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0066 0.0196 0.0151
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0068 0.0227 0.0274
Entamoeba histolytica protein kinase, putative 0.0135 0.0969 0.2502
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0492 0.0492
Brugia malayi Protein kinase domain containing protein 0.0118 0.0781 0.0781
Entamoeba histolytica protein kinase domain containing protein 0.0085 0.041 0.0985
Echinococcus multilocularis insulin receptor 0.0394 0.3876 0.7805
Brugia malayi Protein kinase domain containing protein 0.0278 0.2576 0.2576
Schistosoma mansoni serine/threonine protein kinase 0.0349 0.3371 0.7066
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0149 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0096 0.054 0.054
Entamoeba histolytica serine/threonine protein kinase, putative 0.0266 0.2446 0.6506
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0124 0.0851 0.1713
Brugia malayi Variant SH3 domain containing protein 0.0066 0.02 0.02
Echinococcus granulosus N chimaerin 0.0066 0.02 0.0403
Brugia malayi serine/threonine protein kinase 6 0.0085 0.041 0.041
Entamoeba histolytica protein kinase, putative 0.0118 0.0781 0.1992
Entamoeba histolytica protein kinase, putative 0.0066 0.0199 0.0414
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0491 0.4966 1
Onchocerca volvulus 0.0064 0.018 0.0461
Schistosoma mansoni tyrosine kinase 0.0063 0.0169 0.0352
Trypanosoma brucei protein kinase, putative 0.0079 0.0348 0.0732
Loa Loa (eye worm) hypothetical protein 0.0121 0.0817 0.0817
Leishmania major protein kinase A catalytic subunit isoform 1 0.0068 0.0227 0.0303
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0066 0.0196 0.0394
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0231 0.2049 0.4126
Schistosoma mansoni serine/threonine protein kinase 0.026 0.2378 0.4984
Toxoplasma gondii aurora kinase 0.0085 0.041 0.0996
Schistosoma mansoni tyrosine kinase 0.0142 0.1057 0.2214
Schistosoma mansoni tyrosine kinase 0.0278 0.2577 0.5401
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0152 0.1168 0.4729
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.07 0.2524
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0349 0.3371 0.6789
Loa Loa (eye worm) hypothetical protein 0.0112 0.0717 0.0717
Trypanosoma cruzi casein kinase, putative 0.0104 0.0628 0.2505
Echinococcus multilocularis calcium dependent protein kinase 0.0068 0.0223 0.045
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.1804 0.3781
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0114 0.0742 0.2555
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0096 0.054 0.4393
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0349 0.073
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0096 0.054 0.1513
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0077 0.0322 0.0649
Brugia malayi hypothetical protein 0.0218 0.1905 0.1905
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.0358 0.1392
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0112 0.0717 0.287
Schistosoma mansoni tyrosine kinase 0.0084 0.0398 0.0832
Onchocerca volvulus Serine\/threonine kinase homolog 0.0266 0.2446 0.7233
Plasmodium falciparum protein serine/threonine kinase-1 0.0149 0.1134 0.9667
Loa Loa (eye worm) hypothetical protein 0.0112 0.0717 0.0717
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0742 0.2676
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0213 0.1854 0.1854
Echinococcus multilocularis titin 0.0058 0.0114 0.023
Brugia malayi Protein kinase domain containing protein 0.0057 0.0102 0.0102
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0409 0.4052 0.816
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0104 0.0628 0.2505
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0149 0.1134 0.3862
Echinococcus granulosus titin 0.0058 0.0114 0.023
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.0742 0.2975
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.1835 0.3846
Echinococcus granulosus mitogen activated protein kinase 11 0.0155 0.1196 0.2408
Plasmodium vivax tyrosine kinase-like protein, putative 0.0076 0.0317 0.2399
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Onchocerca volvulus 0.0061 0.0149 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.1134 0.2375
Echinococcus granulosus cGMP dependent protein kinase 1 0.013 0.092 0.1852
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.1134 0.2375
Echinococcus multilocularis casein kinase I alpha 0.0104 0.0628 0.1265
Schistosoma mansoni protein kinase 0.0188 0.1575 0.3299
Entamoeba histolytica protein kinase, putative 0.0118 0.0781 0.1992
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus multilocularis serine:threonine protein kinase 38 0.0164 0.1295 0.2607
Plasmodium falciparum cGMP-dependent protein kinase 0.013 0.092 0.7547
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0266 0.2446 0.4925
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.1835 0.3846
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.2049 0.4294
Echinococcus granulosus casein kinase I alpha 0.0104 0.0628 0.1265
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0112 0.0717 0.1443
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.0358 0.1392
Giardia lamblia Kinase, STE STE20 0.0081 0.0373 0.0943
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0113 0.0723 0.0723
Trypanosoma cruzi polo-like protein kinase, putative 0.0266 0.2446 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0149 0.1134 0.97
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0158 0.1237 0.5017
Plasmodium falciparum calcium-dependent protein kinase 3 0.0096 0.054 0.3788
Echinococcus granulosus NDR protein kinase 0.0164 0.1295 0.2607
Echinococcus multilocularis dual specificity 0.0135 0.0969 0.1951
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0066 0.02 0.0417
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0114 0.0742 0.0742
Brugia malayi SH2 domain containing protein 0.0061 0.0149 0.0149
Schistosoma mansoni vav2 0.0072 0.027 0.0563
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0348 0.1241
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0363 0.3531 0.3531
Onchocerca volvulus 0.0104 0.0628 0.18
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0152 0.1168 1
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0248 0.2241 0.4512
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0068 0.0227 0.0851
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0455 0.4562 0.9185
Schistosoma mansoni serine/threonine kinase 0.0164 0.1295 0.2713
Plasmodium vivax calcium-dependent protein kinase, putative 0.0096 0.054 0.4393
Echinococcus granulosus tyrosine protein kinase ABL1 0.0061 0.0149 0.0299
Loa Loa (eye worm) hypothetical protein 0.0139 0.1021 0.1021
Echinococcus granulosus tyrosine protein kinase Src42A 0.0085 0.0412 0.0829
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0262 0.2397 0.2397
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.0196 0.0722
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.1134 0.4101
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Echinococcus granulosus cGMP dependent protein kinase 0.013 0.092 0.1852
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0236 0.2109 0.4246
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0066 0.02 0.0403
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0085 0.041 0.0985
Echinococcus multilocularis dual specificity 0.0135 0.0969 0.1951
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0096 0.054 0.4393
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0164 0.1295 0.2607
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0079 0.0341 0.132
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0171 0.1383 0.1383
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0212 0.1835 0.3696
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.014 0.1035 0.2084
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0207 0.1779 0.1779
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.1846 0.6693
Echinococcus granulosus tyrosine protein kinase HCK 0.0096 0.0539 0.1085
Brugia malayi serine/threonine-protein kinase 6 0.0085 0.041 0.041
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0079 0.0341 0.0705
Echinococcus multilocularis PAK box P21 Rho binding 0.006 0.013 0.0261
Echinococcus multilocularis protein kinase shaggy 0.0124 0.0853 0.1718
Echinococcus granulosus casein kinase I alpha 0.0104 0.0628 0.1265
Brugia malayi Protein kinase domain containing protein 0.0077 0.0322 0.0322
Echinococcus multilocularis epidermal growth factor receptor 0.0454 0.4557 0.9176
Onchocerca volvulus Tyrosine kinase homolog 0.0226 0.1991 0.5875
Onchocerca volvulus 0.0058 0.0114 0.0264
Giardia lamblia Kinase, CMGC CK2 0.0096 0.0532 0.1636
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0021 0.0041
Loa Loa (eye worm) hypothetical protein 0.0143 0.1066 0.1066
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.014 0.1035 0.2084
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0124 0.0853 0.1718
Echinococcus granulosus expressed protein 0.0079 0.0341 0.0686
Loa Loa (eye worm) CAMK/PHK protein kinase 0.016 0.1252 0.1252
Trichomonas vaginalis STE family protein kinase 0.0081 0.0373 0.1334
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Schistosoma mansoni ephrin receptor 0.0053 0.0055 0.0113
Onchocerca volvulus 0.0321 0.3063 0.9078
Brugia malayi cell division control protein 2 homolog 0.0114 0.0742 0.0742
Echinococcus multilocularis expressed protein 0.0079 0.0341 0.0686
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0923 0.1932
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0112 0.0717 0.2153
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0156 0.1208 0.4371
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0164 0.1295 0.2607
Echinococcus granulosus cGMP dependent protein kinase 1 0.013 0.092 0.1852
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Toxoplasma gondii CMGC kinase, CK2 family 0.0096 0.0532 0.1481
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0096 0.054 0.1513
Brugia malayi Protein kinase domain containing protein 0.0149 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0463 0.4649 0.4649
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Loa Loa (eye worm) AUR protein kinase 0.0085 0.041 0.041
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0096 0.054 0.054
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0142 0.1057 0.2129
Brugia malayi intracellular kinase 0.0124 0.0853 0.0853
Trypanosoma brucei rac serine-threonine kinase, putative 0.0294 0.2755 1
Brugia malayi map kinase activated protein kinase protein 2 0.039 0.384 0.384
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0235 0.2099 0.4226
Entamoeba histolytica p21-activated kinase 0.0088 0.0443 0.1076
Onchocerca volvulus 0.0124 0.0853 0.2473
Mycobacterium ulcerans hypothetical protein 0.0102 0.0603 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0079 0.0348 0.1349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0492 0.099
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0781 0.1635
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.014 0.1034 0.2081
Plasmodium falciparum calcium-dependent protein kinase 5 0.0096 0.054 0.3788
Trichomonas vaginalis STE family protein kinase 0.006 0.013 0.0447
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0114 0.0742 0.2312
Brugia malayi ephrin receptor 1 precursor 0.0068 0.0218 0.0218
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0124 0.0853 0.0853
Brugia malayi Stress-activated protein kinase jnk-1 0.026 0.2378 0.2378
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.0196 0.0722
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0532 0.1911
Leishmania major casein kinase, putative 0.0104 0.0628 0.2056
Trichomonas vaginalis AGC family protein kinase 0.0184 0.1525 0.5523
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0155 0.1196 0.4537
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0969 0.3501
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0297 0.0679
Loa Loa (eye worm) hypothetical protein 0.0102 0.0606 0.0606
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.005 0.0021 0.0021
Echinococcus granulosus serine threonine protein kinase nrc 0.0152 0.1168 0.2351
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0135 0.0969 0.3124
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Echinococcus multilocularis serine:threonine protein kinase 0.011 0.069 0.1388
Echinococcus granulosus protein kinase 0.0149 0.1128 0.2272
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0155 0.1196 0.1196
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.3371 0.3371
Brugia malayi protein kinase C II. 0.0207 0.1779 0.1779
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0227 0.0801
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.008 0.0358 0.0845
Trichomonas vaginalis AGC family protein kinase 0.0294 0.2755 1
Trichomonas vaginalis CAMK family protein kinase 0.0266 0.2446 0.8874
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0079 0.0348 0.0831
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0492 0.099
Loa Loa (eye worm) AGC/AKT protein kinase 0.0294 0.2755 0.2755
Loa Loa (eye worm) hypothetical protein 0.0082 0.0376 0.0376
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.3371 0.3371
Giardia lamblia Kinase, PLK 0.0266 0.2446 1
Onchocerca volvulus 0.0061 0.0149 0.0367
Loa Loa (eye worm) TK protein kinase 0.0278 0.2576 0.2576
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0218 0.1905 0.3836
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.005 0.0021 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0085 0.041 0.1466
Loa Loa (eye worm) casein kinase 0.0181 0.1488 0.1488
Onchocerca volvulus 0.0174 0.1411 0.4141
Trypanosoma brucei Casein kinase II 0.0096 0.0532 0.1441
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0155 0.1196 0.4845
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0155 0.1196 0.4845
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0081 0.0373 0.0752
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.013 0.092 0.3015
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0124 0.0851 0.1713
Echinococcus multilocularis tyrosine protein kinase Abl 0.0084 0.0398 0.0801
Trichomonas vaginalis AGC family protein kinase 0.0184 0.1525 0.5523
Loa Loa (eye worm) TK protein kinase 0.025 0.227 0.227
Echinococcus multilocularis c Jun NH2 terminal kinase 0.026 0.2378 0.4789
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0081 0.0373 0.0752
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.0742 0.2975
Entamoeba histolytica hypothetical protein 0.0381 0.3735 1
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0445 0.4451 0.4451
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.011 0.069 0.069
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0781 0.3135
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0266 0.2446 0.4925
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0096 0.054 0.1088
Entamoeba histolytica protein kinase domain containing protein 0.0066 0.0196 0.0405
Schistosoma mansoni titin 0.0058 0.0114 0.0237
Brugia malayi Protein kinase domain containing protein 0.0181 0.1494 0.1494
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0149 0.0149
Schistosoma mansoni protein kinase 0.0096 0.0532 0.1113
Brugia malayi hypothetical protein 0.0055 0.0075 0.0075
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0939 1 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.069 0.2484
Schistosoma mansoni protein kinase 0.0149 0.1128 0.2364
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0096 0.0532 0.4319
Onchocerca volvulus 0.0139 0.1021 0.2974
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0491 0.4966 1
Echinococcus multilocularis hypothetical protein 0.0102 0.0606 0.122
Brugia malayi serine/threonine kinase 12 0.0085 0.041 0.041
Trichomonas vaginalis AGC family protein kinase 0.0164 0.1295 0.4686
Echinococcus multilocularis c src tyrosine kinase 0.0084 0.0398 0.0801
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.012 0.0808 0.1627
Echinococcus granulosus tyrosine protein kinase shark 0.0061 0.0149 0.0299
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0213 0.1854 0.1854
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0158 0.0328
Echinococcus granulosus roundabout 2 0.0081 0.0364 0.0734
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0085 0.041 0.0825
Echinococcus granulosus protein kinase shaggy 0.0124 0.0853 0.1718
Schistosoma mansoni rap gtpase-activating protein 0.0112 0.0717 0.1501
Brugia malayi Protein kinase domain containing protein 0.0061 0.0149 0.0149
Brugia malayi Protein kinase domain containing protein 0.016 0.1252 0.1252
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0235 0.2099 0.4226
Echinococcus granulosus dual specificity 0.0135 0.0969 0.1951
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0158 0.0549
Echinococcus granulosus Protein kinase C brain isozyme 0.0246 0.2225 0.4481
Echinococcus multilocularis raf serine:threonine protein kinase 0.0079 0.0349 0.0704
Echinococcus multilocularis mitogen activated protein kinase 14 0.0155 0.1196 0.2408
Echinococcus granulosus fibroblast growth factor receptor 4 0.0236 0.2109 0.4246
Trypanosoma cruzi casein kinase II, putative 0.0096 0.0532 0.2109
Schistosoma mansoni protein kinase 0.043 0.4286 0.8985
Trichomonas vaginalis STE family protein kinase 0.0081 0.0373 0.1334
Loa Loa (eye worm) AUR protein kinase 0.0085 0.041 0.041
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0096 0.054 0.4393
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0066 0.02 0.0403
Schistosoma mansoni protein kinase 0.0081 0.0373 0.0781
Entamoeba histolytica protein kinase, putative 0.0085 0.041 0.0985
Echinococcus granulosus serine:threonine protein kinase 0.011 0.069 0.1388
Echinococcus granulosus serine:threonine protein kinase 3 0.0253 0.2295 0.462
Echinococcus granulosus MAP kinase activated protein kinase 2 0.039 0.384 0.7731
Schistosoma mansoni tyrosine kinase 0.0063 0.0171 0.0356
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Schistosoma mansoni vam6/vps39 related 0.0112 0.0717 0.1501
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0135 0.0969 0.0969
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0076 0.0253
Brugia malayi RhoGAP domain containing protein 0.0066 0.02 0.02
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0227 0.0457
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0055 0.0076 0.0253
Loa Loa (eye worm) hypothetical protein 0.0181 0.1491 0.1491

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.