Detailed information for compound 1537381

Basic information

Technical information
  • TDR Targets ID: 1537381
  • Name: 8-methyl-2-[(4-methyl-6-phenylpyrimidin-2-yl) amino]-1H-quinazolin-4-one
  • MW: 343.382 | Formula: C20H17N5O
  • H donors: 2 H acceptors: 5 LogP: 4.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(Nc2nc(O)c3c(n2)c(C)ccc3)nc(c1)c1ccccc1
  • InChi: 1S/C20H17N5O/c1-12-7-6-10-15-17(12)23-20(24-18(15)26)25-19-21-13(2)11-16(22-19)14-8-4-3-5-9-14/h3-11H,1-2H3,(H2,21,22,23,24,25,26)
  • InChiKey: IGONMWIZMCDFQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-methyl-2-[(4-methyl-6-phenyl-pyrimidin-2-yl)amino]-1H-quinazolin-4-one
  • 8-methyl-2-[(4-methyl-6-phenyl-2-pyrimidinyl)amino]-1H-quinazolin-4-one
  • STOCK3S-14950
  • 8-Methyl-2-(4-methyl-6-phenyl-pyrimidin-2-ylamino)-quinazolin-4-ol
  • ZINC04310941
  • MLS000766647
  • SMR000414622

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0107 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3071 0.8054
Leishmania major cytochrome p450-like protein 0.0023 0.0105 0.0494
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Toxoplasma gondii CAAX amino terminal protease family protein 0.0039 0.0307 0.1085
Echinococcus granulosus cpg binding protein 0.0032 0.0214 0.0252
Echinococcus multilocularis geminin 0.0364 0.4226 0.4226
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0031 0.0146
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0057 0.0517 0.2428
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0044 0.0365 0.0958
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.015 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0097 0.0456
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.008 0.0095
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0348 0.0654
Brugia malayi Hemopexin family protein 0.0051 0.0453 0.1188
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0064 0.0609 0.1598
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0241 0.0849
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0105 0.0494
Leishmania major hexokinase, putative 0.0083 0.0832 0.3903
Schistosoma mansoni hypothetical protein 0.0057 0.0525 0.0619
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0149 0.07
Brugia malayi hypothetical protein 0.0077 0.0766 0.2008
Trichomonas vaginalis esterase, putative 0.0037 0.0284 0.0746
Onchocerca volvulus 0.0021 0.008 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0499 0.0588
Brugia malayi beta-lactamase 0.0037 0.0284 0.0746
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0 0.0001
Mycobacterium ulcerans hypothetical protein 0.0039 0.0307 0.0545
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.005 0.0432 0.1132
Loa Loa (eye worm) hexokinase 0.0083 0.0832 0.2181
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.015 0.0177
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3071 0.8054
Schistosoma mansoni heat shock protein 0.0034 0.0241 0.0283
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0284 0.1004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.245 0.6426
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.015 0.0393
Onchocerca volvulus Matrilysin homolog 0.0036 0.027 0.0948
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0074 0.0345
Echinococcus multilocularis microtubule associated protein 2 0.0718 0.8485 0.8485
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0149 0.0526
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0242 0.0285
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0168 0.1858 0.8719
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0014 0.0038
Leishmania major basic transcription factor 3a, putative 0.0036 0.0271 0.1274
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0107 0.028
Plasmodium falciparum glutathione reductase 0.0066 0.0623 0.2202
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2798 0.3297
Loa Loa (eye worm) matrixin family protein 0.0088 0.089 0.2334
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0284 0.0335
Echinococcus multilocularis hexokinase 0.0083 0.0832 0.0832
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0296 0.1046
Schistosoma mansoni hexokinase 0.0083 0.0832 0.098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.015 0.0393
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0107 0.0378
Schistosoma mansoni hypothetical protein 0.0051 0.0453 0.0534
Echinococcus granulosus lamin 0.0058 0.0532 0.0627
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2798 0.2798
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.0311 0.0816
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0014 0.0017
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.0623 0.0735
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0032 0.0215 0.0564
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0132 0.1422 0.1676
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.015 0.0526
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0071 0.0689 0.0689
Plasmodium vivax endoplasmin, putative 0.0034 0.0241 0.0849
Brugia malayi thymidylate synthase 0.0119 0.1271 0.3334
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0105 0.0124
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.133 0.3487
Brugia malayi glutaminase DH11.1 0.033 0.3813 1
Schistosoma mansoni hypothetical protein 0.0364 0.4226 0.498
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0741 0.0741
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.0311 0.0816
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0031 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2072 0.5434
Echinococcus multilocularis lamin 0.0058 0.0532 0.0532
Loa Loa (eye worm) cytochrome P450 0.0023 0.0105 0.0276
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0014 0.0068
Schistosoma mansoni survival motor neuron protein 0.005 0.0438 0.0516
Brugia malayi follicle stimulating hormone receptor 0.0243 0.2767 0.7256
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0168 0.1858 0.6561
Trypanosoma cruzi hexokinase, putative 0.0083 0.0832 0.3903
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0158 0.0141
Brugia malayi glutathione reductase 0.0066 0.0623 0.1635
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0689 0.3232
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.005 0.0432 0.1524
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0746
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0284 0.0999
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0284 0.0746
Brugia malayi nuclear receptor NHR-88 0.0026 0.015 0.0393
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.0311 0.0816
Treponema pallidum hypothetical protein 0.0039 0.0307 0.2763
Brugia malayi hypothetical protein 0.0021 0.008 0.021
Brugia malayi hypothetical protein 0.0026 0.0149 0.0391
Loa Loa (eye worm) hypothetical protein 0.0107 0.1125 0.2951
Plasmodium vivax hexokinase, putative 0.0083 0.0832 0.2937
Echinococcus granulosus dihydrofolate reductase 0.0049 0.042 0.0494
Loa Loa (eye worm) fli-1 protein 0.0229 0.259 0.6791
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0041 0.0192
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0241 0.1129
Onchocerca volvulus 0.003 0.0193 0.0677
Loa Loa (eye worm) glutaminase 2 0.033 0.3813 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0097 0.0306
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0044 0.0365 0.1299
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Schistosoma mansoni glutaminase 0.033 0.3813 0.4494
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0086 0.0871 0.1027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0746
Plasmodium vivax glutathione reductase, putative 0.0066 0.0623 0.2202
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0499 0.0499
Loa Loa (eye worm) hexokinase 0.0052 0.046 0.1205
Echinococcus multilocularis tumor protein p63 0.0351 0.407 0.407
Brugia malayi Matrixin family protein 0.0036 0.027 0.0709
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0023 0.0105 0.0336
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.004 0.0311 0.1099
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0158 0.0739
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0271 0.0958
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0107 0.028
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0023 0.0105 0.0336
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0031
Mycobacterium ulcerans hypothetical protein 0.0037 0.0284 0.0483
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0191 0.2131 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0107 0.0005
Schistosoma mansoni microtubule-associated protein tau 0.0718 0.8485 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0168 0.1858 0.8719
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.015 0.0393
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0241 0.0574
Schistosoma mansoni hypothetical protein 0.0034 0.0242 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0049 0.042 0.0848
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1958 0.5134
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0271 0.0647
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0149 0.07
Brugia malayi hypothetical protein 0.0014 0 0.0001
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.017 0.017
Schistosoma mansoni coup transcription factor 0.0026 0.015 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0284 0.0746
Plasmodium falciparum glutathione reductase 0.0023 0.0107 0.0378
Mycobacterium tuberculosis Conserved protein 0.0037 0.0284 0.0999
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.015 0.0393
Brugia malayi Matrixin family protein 0.0036 0.027 0.0709
Plasmodium falciparum dihydroorotase, putative 0.0249 0.2832 1
Schistosoma mansoni ets-related 0.0229 0.259 0.3052
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.0393
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0296 0.0349
Schistosoma mansoni endoplasmin 0.0034 0.0241 0.0283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.015 0.0393
Mycobacterium tuberculosis Hypothetical protein 0.0057 0.0517 0.186
Echinococcus granulosus heat shock protein 90 0.0034 0.0241 0.0283
Entamoeba histolytica hexokinase 2 0.0083 0.0832 0.1984
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0014 0.0017
Schistosoma mansoni lipoxygenase 0.0123 0.1312 0.1546
Echinococcus multilocularis thymidylate synthase 0.0119 0.1271 0.1271
Brugia malayi hexokinase 0.0083 0.0832 0.2181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0023 0.0105 0.0336
Mycobacterium tuberculosis Conserved protein 0.0037 0.0284 0.0999
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0023 0.0105 0.0336
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0031 0.0146
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0284 0.0746
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0296 0.0706
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.015 0.0177
Mycobacterium ulcerans lipase LipD 0.0037 0.0284 0.0483
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0284 0.0483
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0158 0.0413
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0158 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0499 0.0588
Echinococcus granulosus dna polymerase kappa 0.0043 0.0348 0.041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.015 0.015
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0532 0.1395
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0107 0.0502
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0158 0.2675
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0149 0.0526
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.015 0.0177
Onchocerca volvulus 0.0021 0.008 0.0281
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0193 0.0506
Loa Loa (eye worm) doublecortin family protein 0.0021 0.008 0.021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.015 0.0393
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0158 0.0739
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0039 0.0307 0.1083
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.015 0.0526
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0014 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.015 0.0393
Onchocerca volvulus 0.0037 0.0284 0.0998
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1958 0.5134
Brugia malayi Endoplasmin precursor 0.0034 0.0241 0.0631
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3071 0.8054
Brugia malayi Hexokinase family protein 0.0083 0.0832 0.2181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0149 0.0526
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0023 0.0105 0.0336
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3071 0.8054
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0689 0.3232
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0284 0.0483
Brugia malayi polk-prov protein 0.0032 0.0223 0.0584
Entamoeba histolytica CAAX prenyl protease family 0.0191 0.2131 0.5083
Brugia malayi beta-lactamase family protein 0.0037 0.0284 0.0746
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.1125 0.2951
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.004 0.0311 0.0743
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0191 0.2131 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0284 0.0335
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0296 0.0515
Trypanosoma brucei hexokinase, putative 0.0083 0.0832 0.3903
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.0393
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0242 0.0242
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0031 0.011
Loa Loa (eye worm) hexokinase 0.0026 0.0142 0.0372
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Plasmodium vivax dihydroorotase, putative 0.0249 0.2832 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.0105 0.0494
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0215 0.0254
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.008 0.0283
Brugia malayi beta-NAC-like protein 0.0036 0.0271 0.0712
Brugia malayi Cytochrome P450 family protein 0.0023 0.0105 0.0276
Schistosoma mansoni hypothetical protein 0.0425 0.4961 0.5847
Schistosoma mansoni thyroid hormone receptor 0.0026 0.015 0.0177
Brugia malayi heat shock protein 90 0.0034 0.0241 0.0631
Echinococcus granulosus dnaJ subfamily B 0.0425 0.4961 0.5847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0499 0.0588
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0105 0.0494
Echinococcus multilocularis hexokinase 0.0083 0.0832 0.0832
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0271 0.0958
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.1312 0.1546
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0284 0.0999
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0716 0.1879
Brugia malayi intermediate filament protein 0.0058 0.0532 0.1395
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0296 1
Echinococcus multilocularis heat shock protein 90 0.0034 0.0241 0.0241
Echinococcus granulosus lamin dm0 0.0058 0.0532 0.0627
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0499 0.1309
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0766 0.0902
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.015 0.0393
Brugia malayi cytochrome P450 0.0023 0.0105 0.0276
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0107 0.0502
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0031 0.011
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0023 0.0105 0.0336
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.1129
Schistosoma mansoni hypothetical protein 0.0034 0.0242 0.0285
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.015 0.0177
Echinococcus multilocularis dihydrofolate reductase 0.0049 0.042 0.042
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.015 0.0177
Onchocerca volvulus 0.025 0.2851 1
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0031 0.0082
Echinococcus multilocularis CAAX prenyl protease 2 0.0191 0.2131 0.2131
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0031 0.0146
Brugia malayi hypothetical protein 0.0021 0.008 0.021
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0284 0.1537
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.015 0.0393
Entamoeba histolytica hypothetical protein 0.0077 0.0766 0.1827
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0105 0.0494
Schistosoma mansoni cpg binding protein 0.0032 0.0214 0.0252
Trypanosoma brucei unspecified product 0.0036 0.0265 0.1245
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0105 0.0494
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1958 0.5134
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.3071 0.8054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.015 0.0393
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0348 0.1633
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0208 0.0544
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0529 0.1868
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0037
Brugia malayi Pre-SET motif family protein 0.0032 0.0215 0.0564
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0158 0.0186
Loa Loa (eye worm) glutaminase 0.033 0.3813 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0105 0.0276
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0023 0.0107 0.0342
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0014 0.0038
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0083 0.0218
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0149 0.0526
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0049 0.042 0.2695
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.015 0.0177
Entamoeba histolytica hypothetical protein 0.0103 0.1073 0.256
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.008 0.0283
Trypanosoma brucei membrane transporter protein, putative 0.0071 0.0689 0.3232
Loa Loa (eye worm) hypothetical protein 0.0127 0.1369 0.359
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.008 0.008
Plasmodium falciparum thioredoxin reductase 0.0023 0.0107 0.0378
Trypanosoma cruzi hexokinase, putative 0.0083 0.0832 0.3903
Plasmodium vivax protease, putative 0.0039 0.0307 0.1085
Entamoeba histolytica CAAX amino terminal protease family 0.0039 0.0307 0.0733
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.015 0.0393
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0023 0.0105 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0041 0.0192
Onchocerca volvulus 0.0083 0.0832 0.2918
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Giardia lamblia Grp94/Hsp90 0.0027 0.0158 0.0147
Onchocerca volvulus 0.0052 0.046 0.1612
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0023 0.0105 0.0336
Brugia malayi Hexokinase family protein 0.0052 0.046 0.1205
Schistosoma mansoni hypothetical protein 0.0073 0.0716 0.0844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.015 0.0393
Leishmania major trypanothione reductase 0.0066 0.0623 0.2926
Loa Loa (eye worm) hypothetical protein 0.0021 0.008 0.021
Trypanosoma brucei trypanothione reductase 0.0066 0.0623 0.2926
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.004 0.0311 0.0367
Entamoeba histolytica hypothetical protein 0.0077 0.0766 0.1827
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.133 0.3487
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.0105 0.0494
Leishmania major hypothetical protein, conserved 0.0071 0.0689 0.3232
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0242 0.0285
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0438 0.1148
Echinococcus granulosus dna polymerase eta 0.0015 0.0014 0.0017
Echinococcus granulosus hexokinase 0.0083 0.0832 0.098
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.0311 0.0816
Entamoeba histolytica hexokinase 1 0.0083 0.0832 0.1984
Entamoeba histolytica CAAX amino terminal protease family 0.0039 0.0307 0.0733
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0584 0.1531
Toxoplasma gondii ABC1 family protein 0.0037 0.0284 0.1004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.2717 1
Onchocerca volvulus Huntingtin homolog 0.0127 0.1369 0.4803
Schistosoma mansoni loxhd1 0.0021 0.008 0.0095
Schistosoma mansoni polycystin 1-related 0.0021 0.008 0.0095
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.3071 0.8054
Onchocerca volvulus Huntingtin homolog 0.0127 0.1369 0.4803
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0168 0.1858 0.8719
Brugia malayi ubiquitin conjugating enzyme protein 13 0.004 0.0311 0.0816
Onchocerca volvulus 0.0037 0.0284 0.0998
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0168 0.1858 0.6561
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0031 0.0031
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0348 0.0912
Giardia lamblia DNA repair protein RAD52 0.0362 0.4192 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0746
Echinococcus multilocularis heat shock protein 90 0.0027 0.0158 0.0158
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0689 0.3232
Mycobacterium tuberculosis Conserved protein 0.0037 0.0284 0.0999
Schistosoma mansoni cpg binding protein 0.003 0.0193 0.0228
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0284 0.0284
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0023 0.0105 0.0336
Schistosoma mansoni transcription factor btf3 0.0036 0.0271 0.032
Chlamydia trachomatis hypothetical protein 0.0039 0.0307 0.6405
Brugia malayi CXXC zinc finger family protein 0.003 0.0193 0.0506
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0741 0.0873
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0766 0.0902
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0191 0.2131 0.2511
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2072 0.5434
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0689 0.3232
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0158 0.0529
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0242 0.0634
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.015 0.0177
Onchocerca volvulus Matrilysin homolog 0.008 0.0803 0.2816
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0023 0.0105 0.0336
Echinococcus granulosus tumor protein p63 0.0351 0.407 0.4796
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0223 0.1045
Brugia malayi nuclear receptor RXR 0.0014 0 0.0001
Plasmodium falciparum endoplasmin, putative 0.0021 0.0083 0.0293
Loa Loa (eye worm) hypothetical protein 0.0026 0.0151 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0041 0.0192
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0107 0.0378
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0413
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0194 0.0228
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.1129
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0107 0.0502
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.4961 0.4961
Brugia malayi hypothetical protein 0.0127 0.1369 0.359
Schistosoma mansoni heat shock protein 0.0034 0.0241 0.0283
Brugia malayi dihydrofolate reductase family protein 0.0049 0.042 0.11
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.015 0.015
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0284 0.0746
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.1129
Onchocerca volvulus Hexokinase homolog 0.0052 0.046 0.1612
Loa Loa (eye worm) hypothetical protein 0.0021 0.008 0.021
Leishmania major cytochrome p450-like protein 0.0023 0.0105 0.0494
Echinococcus granulosus transcription factor btf3 0.0036 0.0271 0.032
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.004 0.0311 0.0816
Leishmania major hexokinase, putative 0.0083 0.0832 0.3903
Schistosoma mansoni cpg binding protein 0.0032 0.0214 0.0252
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.008 0.0095
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.2767 0.7256
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0107 0.0342
Echinococcus granulosus heat shock protein 90 0.0027 0.0158 0.0186
Brugia malayi MH2 domain containing protein 0.0124 0.133 0.3487
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0296 0.139
Plasmodium falciparum heat shock protein 90 0.0034 0.0241 0.0849
Loa Loa (eye worm) hypothetical protein 0.0044 0.0365 0.0958
Schistosoma mansoni cytochrome P450 0.0023 0.0105 0.0124
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0107 0.0502
Toxoplasma gondii hypothetical protein 0.0039 0.0307 0.1085
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0107 0.0126
Brugia malayi Cytochrome P450 family protein 0.0062 0.0584 0.1531
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0038
Brugia malayi Matrixin family protein 0.0088 0.089 0.2334
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0348 0.1633
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0215 0.0254
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0746
Schistosoma mansoni endoplasmin 0.0034 0.0241 0.0283
Onchocerca volvulus 0.0051 0.0453 0.159
Loa Loa (eye worm) dihydrofolate reductase 0.0049 0.042 0.11
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0023 0.0105 0.0336
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0107 0.0502
Trypanosoma brucei hexokinase 0.0083 0.0832 0.3903
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.015 0.0393
Schistosoma mansoni lamin 0.0058 0.0532 0.0627
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0031 0.0061
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0103 0.1073 0.256
Echinococcus granulosus hexokinase type 2 0.0083 0.0832 0.098
Brugia malayi Dihydrofolate reductase 0.0049 0.042 0.11
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0223 0.1045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.015 0.0393
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.008 0.008
Echinococcus multilocularis transcription factor btf3 0.0036 0.0271 0.0271
Brugia malayi hypothetical protein 0.0057 0.0517 0.1357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.015 0.0393
Echinococcus granulosus FTZ F1 alpha 0.0026 0.015 0.0177
Brugia malayi Pre-SET motif family protein 0.0217 0.245 0.6426
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.015 0.0177
Loa Loa (eye worm) hypothetical protein 0.0057 0.0519 0.1362
Loa Loa (eye worm) hypothetical protein 0.0073 0.0716 0.1879
Echinococcus granulosus hexokinase 0.0083 0.0832 0.098
Treponema pallidum heat shock protein 90 0.0027 0.0158 0.0698
Onchocerca volvulus 0.0083 0.0832 0.2918
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0065 0.0614 0.0614
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0265 0.1245
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0241 0.0631
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0215 0.076
Trichomonas vaginalis glutaminase, putative 0.033 0.3813 1
Brugia malayi beta-lactamase family protein 0.0037 0.0284 0.0746
Leishmania major hypothetical protein, conserved 0.0037 0.0284 0.1335
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0271 0.1274
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.0623 0.2926
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.0623 0.1635
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.015 0.015
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0296 0.139
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0107 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0284 0.1335
Brugia malayi Cytochrome P450 family protein 0.0023 0.0105 0.0276
Loa Loa (eye worm) matrix metalloproteinase 0.0036 0.027 0.0709
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0107 0.0502
Loa Loa (eye worm) thymidylate synthase 0.0119 0.1271 0.3334
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0058 0.0532 0.1395
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0241 0.0849
Loa Loa (eye worm) hypothetical protein 0.0032 0.0223 0.0584
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.015 0.0177
Schistosoma mansoni hypothetical protein 0.0023 0.0105 0.0124
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0031
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0014 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0296 0.0777
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.015 0.0393
Schistosoma mansoni intermediate filament proteins 0.0058 0.0532 0.0627
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0453 0.0534
Schistosoma mansoni hypothetical protein 0.005 0.0438 0.0516
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0107 0.0502
Schistosoma mansoni rab6-interacting 0.0021 0.008 0.0095
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0119 0.1271 0.1498
Mycobacterium ulcerans beta-lactamase 0.0037 0.0284 0.0483
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3071 0.8054
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.1129
Trypanosoma brucei membrane transporter protein, putative 0.0071 0.0689 0.3232
Loa Loa (eye worm) hypothetical protein 0.0034 0.0242 0.0634
Brugia malayi Thioredoxin reductase 0.0066 0.0623 0.1635
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1958 0.5134
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0248 0.1221
Loa Loa (eye worm) matrixin family protein 0.008 0.0803 0.2105
Toxoplasma gondii TIM10 family protein, putative 0.005 0.0432 0.1524
Echinococcus multilocularis RUN 0.0021 0.008 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.015 0.0177
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0271 0.1274
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0031 0.011
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0034 0.009
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Onchocerca volvulus 0.0051 0.0453 0.1589
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0248 0.0862
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.017 0.0201
Schistosoma mansoni nuclear hormone receptor 0.0026 0.015 0.0177
Trypanosoma brucei membrane transporter protein, putative 0.0071 0.0689 0.3232
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0107 0.0502
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0107 0.0024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0215 0.0215
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.015 0.015
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0023 0.0105 0.0336
Leishmania major hypothetical protein, conserved 0.0071 0.0689 0.3232
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0191 0.2131 0.2511
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0241 0.1129
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0158 0.0739
Echinococcus multilocularis hexokinase type 2 0.0083 0.0832 0.0832
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0023 0.0105 0.0336
Leishmania major DNA polymerase kappa, putative 0.0022 0.0097 0.0456
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.1125 0.2951
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0307 0.1083
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Plasmodium falciparum hexokinase 0.0083 0.0832 0.2937
Brugia malayi steroid hormone receptor 0.0026 0.015 0.0393
Mycobacterium leprae Probable lipase LipE 0.0037 0.0284 0.1537
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0031 0.0037
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0191 0.2131 0.5588
Brugia malayi CAAX amino terminal protease family protein 0.0191 0.2131 0.5588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0107 0.0502
Plasmodium falciparum thioredoxin reductase 0.0066 0.0623 0.2202
Loa Loa (eye worm) hexokinase type II 0.0083 0.0832 0.2181
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0023 0.0105 0.0336
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.015 0.0393
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0689 0.3232
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.015 0.0393
Brugia malayi Hexokinase family protein 0.0026 0.0142 0.0372
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0023 0.0105 0.0336
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0158 0.0413
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.015 0.015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0499 0.0499
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0119 0.1271 0.4651
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0027 0.0158 0.0448
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0271 0.1274
Brugia malayi isocitrate dehydrogenase 0.0016 0.0031 0.0082
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0284 0.0999
Echinococcus granulosus geminin 0.0364 0.4226 0.498
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0107 0.0502
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0296 0.139
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.0393
Loa Loa (eye worm) hypothetical protein 0.0026 0.0151 0.0395
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0107 0.0502
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0107 0.0378
Toxoplasma gondii thioredoxin reductase 0.0066 0.0623 0.2202
Echinococcus granulosus intermediate filament protein 0.0058 0.0532 0.0627
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1958 0.5134
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.004 0.0311 0.0367
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0215 0.0254
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0014 0.0014
Brugia malayi Matrixin family protein 0.0036 0.027 0.0709
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0241 0.1129
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0296 0.0777
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0119 0.1271 1
Echinococcus multilocularis musashi 0.0058 0.0532 0.0532
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0107 0.0005
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0284 0.0999
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0362 0.4192 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0296 0.0777
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1958 0.5134
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.015 0.0393
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0215 0.0254
Brugia malayi hypothetical protein 0.0017 0.0037 0.0097
Echinococcus multilocularis cpg binding protein 0.0032 0.0214 0.0214
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0766 0.0766
Brugia malayi Doublecortin family protein 0.0021 0.008 0.021
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0191 0.2131 1
Brugia malayi nuclear hormone receptor 0.0026 0.015 0.0393
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.008 0.0095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Echinococcus granulosus microtubule associated protein 2 0.0718 0.8485 1
Onchocerca volvulus 0.0058 0.0532 0.1867
Toxoplasma gondii dihydroorotase 0.0249 0.2832 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0499 0.1309
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.0311 0.1461
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0348 0.0912
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0348 0.0654
Onchocerca volvulus 0.0247 0.2811 0.986
Echinococcus granulosus CAAX prenyl protease 2 0.0191 0.2131 0.2511
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.015 0.0393
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.0709
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.1312 0.1312
Loa Loa (eye worm) hypothetical protein 0.0056 0.0514 0.1348
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0746
Toxoplasma gondii hypothetical protein 0.0039 0.0307 0.1085
Leishmania major DNA polymerase eta, putative 0.0015 0.0014 0.0068
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.1129
Echinococcus multilocularis heat shock protein 0.0034 0.0241 0.0241
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0215 0.0254
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.015 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.015 0.0393
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0242 0.0242
Onchocerca volvulus 0.0119 0.1271 0.446
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0158 0.0413
Brugia malayi hypothetical protein 0.0014 0 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0284 0.1335
Loa Loa (eye worm) hypothetical protein 0.0246 0.2798 0.7337
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Mycobacterium tuberculosis Probable integral membrane protein 0.0039 0.0307 0.1083
Leishmania major hypothetical protein, conserved 0.0026 0.0149 0.07
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.015 0.0393
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0107 0.0378
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.0623 0.2202
Brugia malayi Ets-domain containing protein 0.0075 0.0741 0.1943
Schistosoma mansoni rab6-interacting 0.0021 0.008 0.0095
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0284 0.0335
Chlamydia trachomatis dihydrofolate reductase 0.0049 0.042 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0107 0.0502
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0284 0.0999
Plasmodium falciparum protease, putative 0.0039 0.0307 0.1085
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0028 0.017 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.015 0.0393
Onchocerca volvulus 0.0058 0.0532 0.1867
Schistosoma mansoni lipoxygenase 0.0086 0.0867 0.1022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0532 0.1395
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0241 0.1129
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.015 0.0393
Onchocerca volvulus Matrix metalloproteinase homolog 0.008 0.0803 0.2816
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.005 0.0432 0.1524
Leishmania major cytochrome p450-like protein 0.0023 0.0105 0.0494
Mycobacterium ulcerans glutaminase 0.033 0.3813 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.015 0.0177
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0241 0.035
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0741 0.1943
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0107 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0 0.0001
Echinococcus granulosus RUN 0.0021 0.008 0.0095
Brugia malayi ecdysteroid receptor 0.0026 0.015 0.0393
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.015 0.0177
Schistosoma mansoni DNA polymerase eta 0.0015 0.0014 0.0017
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.004 0.0311 0.1099
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0023 0.0105 0.0336
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0284 0.0746
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0284 0.1335
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0499 0.0588
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0208 0.0544
Echinococcus granulosus GPCR family 2 0.0034 0.0242 0.0285
Echinococcus granulosus endoplasmin 0.0027 0.0158 0.0186
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0271 0.0958
Schistosoma mansoni hypothetical protein 0.0034 0.0242 0.0285
Loa Loa (eye worm) beta-lactamase 0.0037 0.0284 0.0746
Echinococcus multilocularis hexokinase 0.0083 0.0832 0.0832
Brugia malayi Inositol-1 0.0038 0.0296 0.0777
Schistosoma mansoni hypothetical protein 0.0364 0.4226 0.498
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0023 0.0105 0.0336
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.0393
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.015 0.015
Entamoeba histolytica hypothetical protein 0.0077 0.0766 0.1827
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0242 0.0634
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0023 0.0105 0.0336
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0284 0.0746
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.1958 0.6867
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0517 0.1357
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0023 0.0107 0.0342
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0049 0.042 0.1499
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0107 0.0378
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0107 0.0502
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0241 0.1129
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0271 0.0712
Mycobacterium ulcerans hypothetical protein 0.0039 0.0307 0.0545
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0241 0.1129
Brugia malayi Fli-1 protein 0.0229 0.259 0.6791
Schistosoma mansoni hypothetical protein 0.0077 0.0766 0.0902
Echinococcus multilocularis endoplasmin 0.0027 0.0158 0.0158
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0014 0.0017
Mycobacterium ulcerans hydrolase 0.0044 0.0365 0.0702
Entamoeba histolytica hypothetical protein 0.0077 0.0766 0.1827
Loa Loa (eye worm) hypothetical protein 0.0191 0.2131 0.5588
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1958 0.5134
Loa Loa (eye worm) endoplasmin 0.0034 0.0241 0.0631
Echinococcus granulosus hexokinase 0.0083 0.0832 0.098
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0149 0.07
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0241 0.0849
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0105 0.0494
Echinococcus multilocularis expressed protein 0.005 0.0432 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3071 0.8054
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0031 0.0082
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0031 0.0031
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.005 0.0432 0.1132
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0031
Schistosoma mansoni gabp alpha 0.0075 0.0741 0.0873
Onchocerca volvulus 0.0032 0.0215 0.0755
Echinococcus multilocularis 0.0023 0.0105 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0107 0.0502
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0132 0.1422 0.1422
Echinococcus granulosus heat shock protein 0.0034 0.0241 0.0283
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0031 0.011
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.005 0.0432 0.1524
Trypanosoma cruzi membrane transporter protein, putative 0.0071 0.0689 0.3232
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0532 0.1395
Schistosoma mansoni inositol monophosphatase 0.0038 0.0296 0.0349
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Loa Loa (eye worm) glutathione reductase 0.0066 0.0623 0.1635
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.015 0.015
Onchocerca volvulus 0.005 0.0438 0.1536
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0241 0.0631
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0284 0.0999
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.1129
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0271 0.0712
Schistosoma mansoni dihydrofolate reductase 0.0049 0.042 0.0494
Brugia malayi Matrixin family protein 0.0036 0.027 0.0709
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0284 0.0746
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0107 0.0378
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.015 0.0177
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.004 0.0311 0.1461
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0034 0.009
Plasmodium vivax SET domain protein, putative 0.0032 0.0215 0.076
Echinococcus granulosus expressed protein 0.005 0.0432 0.0509
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0391
Mycobacterium ulcerans integral membrane protein 0.0039 0.0307 0.0545
Echinococcus multilocularis GPCR, family 2 0.0034 0.0242 0.0242
Giardia lamblia Hypothetical protein 0.0191 0.2131 0.4966
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0105 0.0276
Onchocerca volvulus 0.0036 0.027 0.0948
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.0709
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0241 0.1129
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.0311 0.1461
Loa Loa (eye worm) hypothetical protein 0.0127 0.1369 0.359
Loa Loa (eye worm) hypothetical protein 0.0051 0.0453 0.1188
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.004 0.0311 0.0311
Trypanosoma brucei ubiquitin-protein ligase, putative 0.004 0.0311 0.1461
Onchocerca volvulus 0.0083 0.0832 0.2918
Echinococcus multilocularis dna polymerase eta 0.0015 0.0014 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.1125 0.2951
Schistosoma mansoni thyroid hormone receptor 0.0026 0.015 0.0177
Brugia malayi hypothetical protein 0.0246 0.2798 0.7337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0499 0.0588
Trypanosoma brucei hexokinase 0.0083 0.0832 0.3903
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.0105 0.0372
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0168 0.1858 0.6561
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0107 0.028
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.1129
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0023 0.0107 0.0015
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0031 0.0146
Loa Loa (eye worm) hexokinase 0.0083 0.0832 0.2181
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0271 0.0712
Trichomonas vaginalis set domain proteins, putative 0.0247 0.2811 0.7371
Trypanosoma brucei CAAX amino terminal protease, putative 0.0191 0.2131 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.0393
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.015 0.0177
Trypanosoma brucei MATE efflux family protein, putative 0.0071 0.0689 0.3232
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.015 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0348 0.1633
Brugia malayi Ets-domain containing protein 0.0075 0.0741 0.1943
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0242 0.0634
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0105 0.0276
Loa Loa (eye worm) pax transcription factor protein 2 0.025 0.2851 0.7475
Echinococcus multilocularis lamin dm0 0.0058 0.0532 0.0532
Mycobacterium ulcerans thymidylate synthase 0.0119 0.1271 0.3145
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0036 0.027 0.0318
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0107 0.0126
Treponema pallidum hexokinase (hxk) 0.0083 0.0832 1
Brugia malayi Cytochrome P450 family protein 0.0023 0.0105 0.0276
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.1129
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0296 0.139
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.008 0.008
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0023 0.0105 0.0336
Brugia malayi hexokinase type II 0.0026 0.0151 0.0395
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0241 0.1129
Echinococcus granulosus thymidylate synthase 0.0119 0.1271 0.1498
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0271 0.0712
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0014 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0107 0.0502
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0284 0.0999
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0039 0.0307 0.1083
Entamoeba histolytica hypothetical protein 0.0036 0.0271 0.0647
Schistosoma mansoni hypothetical protein 0.0021 0.008 0.0095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0107 0.0502
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0107 0.0502
Onchocerca volvulus 0.0037 0.0284 0.0998
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.004 0.0311 0.1099
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.015 0.015
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.0105 0.0494
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0296 0.0296
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0241 0.0574
Schistosoma mansoni lamin 0.0058 0.0532 0.0627
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.005 0.0432 0.0509
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0611 0.072
Onchocerca volvulus 0.0026 0.015 0.0526
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.015 0.0526
Loa Loa (eye worm) inositol-1 0.0038 0.0296 0.0777
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.0393
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.0623 0.2253
Schistosoma mansoni inositol monophosphatase 0.0038 0.0296 0.0349
Mycobacterium leprae PROBABLE HYDROLASE 0.0044 0.0365 0.2232
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.0709
Toxoplasma gondii hexokinase 0.0083 0.0832 0.2937
Schistosoma mansoni hypothetical protein 0.0034 0.0242 0.0285
Brugia malayi Pax transcription factor protein 2 0.025 0.2851 0.7475
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.1129
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0023 0.0105 0.0336
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0083 0.0218
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0071 0.0689 0.0811
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0097 0.0456
Schistosoma mansoni multidrug resistance protein 0.0071 0.0689 0.0811

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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