Detailed information for compound 1560425

Basic information

Technical information
  • TDR Targets ID: 1560425
  • Name: [2-[(3,4-dimethoxyphenyl)methylamino]-2-oxoet hyl] 2-furan-2-ylquinoline-4-carboxylate
  • MW: 446.452 | Formula: C25H22N2O6
  • H donors: 1 H acceptors: 3 LogP: 3.59 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)CNC(=O)COC(=O)c1cc(nc2c1cccc2)c1ccco1
  • InChi: 1S/C25H22N2O6/c1-30-22-10-9-16(12-23(22)31-2)14-26-24(28)15-33-25(29)18-13-20(21-8-5-11-32-21)27-19-7-4-3-6-17(18)19/h3-13H,14-15H2,1-2H3,(H,26,28)
  • InChiKey: KQFYPWYACRHAHY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(3,4-dimethoxyphenyl)methylamino]-2-oxo-ethyl] 2-(2-furyl)quinoline-4-carboxylate
  • 2-(2-furyl)-4-quinolinecarboxylic acid [2-[(3,4-dimethoxyphenyl)methylamino]-2-oxoethyl] ester
  • 2-(2-furyl)cinchoninic acid [2-[(3,4-dimethoxybenzyl)amino]-2-keto-ethyl] ester
  • [2-[(3,4-dimethoxyphenyl)methylamino]-2-oxo-ethyl] 2-furan-2-ylquinoline-4-carboxylate
  • Oprea1_444690
  • T5428290

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin-conjugating enzyme E2I Starlite/ChEMBL No references
Homo sapiens calcium channel, voltage-dependent, N type, alpha 1B subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i Get druggable targets OG5_127729 All targets in OG5_127729
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Theileria parva ubiquitin-conjugating enzyme, putative Get druggable targets OG5_127729 All targets in OG5_127729
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus ubiquitin conjugating enzyme e2 i Get druggable targets OG5_127729 All targets in OG5_127729
Schistosoma japonicum ko:K10577 ubiquitin-conjugating enzyme E2 I, putative Get druggable targets OG5_127729 All targets in OG5_127729
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Plasmodium knowlesi SUMO-conjugating enzyme UBC9, putative Get druggable targets OG5_127729 All targets in OG5_127729
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Plasmodium berghei SUMO-conjugating enzyme UBC9, putative Get druggable targets OG5_127729 All targets in OG5_127729
Loa Loa (eye worm) ube2i2 protein Get druggable targets OG5_127729 All targets in OG5_127729
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Candida albicans ubiquitin-conjugating enzyme Get druggable targets OG5_127729 All targets in OG5_127729
Leishmania infantum ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127729 All targets in OG5_127729
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127729 All targets in OG5_127729
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127729 All targets in OG5_127729
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative Get druggable targets OG5_127729 All targets in OG5_127729
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative Get druggable targets OG5_127729 All targets in OG5_127729
Leishmania major ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127729 All targets in OG5_127729
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I Get druggable targets OG5_127729 All targets in OG5_127729
Entamoeba histolytica ubiquitin-conjugating enzyme family protein Get druggable targets OG5_127729 All targets in OG5_127729
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein Get druggable targets OG5_127729 All targets in OG5_127729
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Leishmania donovani ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127729 All targets in OG5_127729
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Entamoeba histolytica ubiquitin-conjugating enzyme family protein Get druggable targets OG5_127729 All targets in OG5_127729
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Plasmodium falciparum SUMO-conjugating enzyme UBC9 Get druggable targets OG5_127729 All targets in OG5_127729
Leishmania mexicana ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127729 All targets in OG5_127729
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127729 All targets in OG5_127729
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127729 All targets in OG5_127729
Babesia bovis ubiquitin conjugating enzyme, putative Get druggable targets OG5_127729 All targets in OG5_127729
Brugia malayi ube2i2 protein Get druggable targets OG5_127729 All targets in OG5_127729
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum Ubiquitin carrier protein (EC 6.3.2.-), related Get druggable targets OG5_127729 All targets in OG5_127729
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Babesia bovis ubiquitin conjugating enzyme, putative Get druggable targets OG5_127729 All targets in OG5_127729
Candida albicans ubiquitin-conjugating enzyme Get druggable targets OG5_127729 All targets in OG5_127729
Giardia lamblia UBC3 Get druggable targets OG5_127729 All targets in OG5_127729
Cryptosporidium parvum ubiquitin conjugating enzyme, putative Get druggable targets OG5_127729 All targets in OG5_127729
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Leishmania braziliensis ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127729 All targets in OG5_127729
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin-conjugating enzyme E2, putative ubiquitin-conjugating enzyme E2I 158 aa 154 aa 40.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0287 0.0285
Brugia malayi ecdysteroid receptor 0.0072 0.0477 0.0475
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0071 0.0469 0.0532
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0116 0.0832 0.0946
Schistosoma mansoni zinc finger protein 0.0034 0.017 0.0192
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0203 0.0229
Brugia malayi nicalin 0.0014 0.0009 0.0007
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0418 0.655
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Echinococcus granulosus BC026374 protein S09 family 0.0027 0.0112 0.0126
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0072 0.0477 0.0542
Echinococcus granulosus methionyl aminopeptidase 2 0.0055 0.0342 0.0387
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0072 0.0477 0.0542
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.017 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0187 0.021
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.003 0.0139 0.2161
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0019 0.002
Loa Loa (eye worm) voltage-dependent calcium channel 0.0024 0.0092 0.009
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0017
Echinococcus multilocularis acetylcholinesterase 0.0159 0.1178 0.1341
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0019 0.002
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0047 0.0066
Loa Loa (eye worm) heat shock protein 75 0.0027 0.011 0.0108
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.2086 0.2084
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0422 0.0479
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Toxoplasma gondii methionine aminopeptidase 0.004 0.0217 0.4596
Brugia malayi jmjC domain containing protein 0.0031 0.0145 0.0143
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0027 0.0112 0.0336
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0072 0.0477 0.0542
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0109 0.0122
Brugia malayi TAR-binding protein 0.0065 0.0422 0.042
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0418 0.0609
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.011 0.0158
Onchocerca volvulus 0.0279 0.2146 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0047 0.0045
Onchocerca volvulus 0.0143 0.1049 0.4884
Treponema pallidum fructose-bisphosphate aldolase 0.086 0.683 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0051
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.0145 0.3055
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0147 0.0165
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0071 0.0469 0.1423
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0163 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.001
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0052 0.1062
Schistosoma mansoni hypothetical protein 0.002 0.0054 0.0059
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0014 0.0009 0.001
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.011 0.2307
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0376 0.0427
Brugia malayi hypothetical protein 0.0034 0.017 0.0168
Brugia malayi Uncoordinated protein 44 0.0031 0.0147 0.0145
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0055 0.0342 0.1583
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0312 0.0353
Echinococcus multilocularis para nitrobenzyl esterase 0.0027 0.0112 0.0126
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.042 0.3283 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0072 0.0477 0.0475
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.011 0.2307
Echinococcus granulosus RUN 0.002 0.0054 0.0059
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0637 1
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.5307 0.605
Trichomonas vaginalis Sentrin-specific protease, putative 0.0065 0.0416 0.0607
Brugia malayi Muscleblind-like protein 0.0145 0.1067 0.1065
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.017 0.0168
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.0418 0.6561
Loa Loa (eye worm) calcium channel 0.0116 0.0832 0.083
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.0163 0.0183
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0312 0.0453
Echinococcus granulosus carboxylesterase 5A 0.0159 0.1178 0.1341
Loa Loa (eye worm) hypothetical protein 0.0045 0.0258 0.0256
Brugia malayi hypothetical protein 0.0027 0.0112 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0112 0.011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0203 0.0201
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0019 0.002
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0312 0.4875
Loa Loa (eye worm) hypothetical protein 0.0091 0.0633 0.0632
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0056 0.0348 0.0394
Brugia malayi Carboxylesterase family protein 0.0159 0.1178 0.1176
Brugia malayi hypothetical protein 0.0038 0.0203 0.0201
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0057 0.0063
Loa Loa (eye worm) hypothetical protein 0.0033 0.0163 0.0161
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0187 0.021
Schistosoma mansoni glutaminase 0.0266 0.2039 0.2323
Onchocerca volvulus 0.002 0.0054 0.0243
Schistosoma mansoni nuclear receptor 0.0034 0.017 0.0192
Brugia malayi tailless protein 0.0034 0.017 0.0168
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.11 0.877 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0422 0.0479
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.011 0.2307
Brugia malayi indoleamine 2,3-dioxygenase 0.11 0.877 0.877
Loa Loa (eye worm) hypothetical protein 0.0072 0.0477 0.0475
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0047 0.0066
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0054 0.0059
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.004 0.0217 0.0245
Treponema pallidum heat shock protein 90 0.0052 0.0312 0.0453
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0072 0.0477 0.0542
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0254 0.0252
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0147 0.0165
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0072 0.0477 0.0542
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.0145 0.0163
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0059 0.0373 0.7937
Loa Loa (eye worm) acetylcholinesterase 1 0.0159 0.1178 0.1176
Loa Loa (eye worm) hypothetical protein 0.0072 0.0477 0.0475
Loa Loa (eye worm) hypothetical protein 0.0159 0.1178 0.1176
Brugia malayi PHD-finger family protein 0.0029 0.0131 0.0129
Loa Loa (eye worm) hypothetical protein 0.0072 0.0477 0.0475
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0145 0.2245
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.017 0.0784
Brugia malayi Peptidase family M28 containing protein 0.0014 0.0009 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0145 0.0143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.086 0.683 1
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0477 0.0542
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0054 0.0059
Brugia malayi Death domain containing protein 0.0031 0.0147 0.0145
Schistosoma mansoni nicalin (M28 family) 0.0014 0.0009 0.0008
Schistosoma mansoni zinc finger protein 0.0018 0.004 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0707
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0047 0.0045
Schistosoma mansoni hypothetical protein 0.0031 0.0147 0.0165
Loa Loa (eye worm) heat shock protein 90 0.0065 0.0418 0.0416
Schistosoma mansoni hypothetical protein 0.11 0.877 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0848 0.0846
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.017 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0052 0.078
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0145 0.0143
Schistosoma mansoni nuclear receptor 0.0034 0.017 0.0192
Echinococcus multilocularis RUN 0.002 0.0054 0.0059
Loa Loa (eye worm) Ulp1 protease 0.0065 0.0416 0.0414
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0137
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.004 0.0217 0.0654
Brugia malayi ecdysone receptor 0.0034 0.017 0.0168
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.011 0.2307
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0049 0.0293 0.0332
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0047 0.0051
Schistosoma mansoni jumonji domain containing protein 0.0116 0.083 0.0944
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0072 0.0477 0.0475
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0047 0.0045
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Echinococcus granulosus para nitrobenzyl esterase 0.0027 0.0112 0.0126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0112 0.011
Brugia malayi Protein kinase domain containing protein 0.0092 0.0637 0.0635
Echinococcus granulosus phd:f box containing protein 0.0031 0.0145 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.002
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0109 0.0122
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0059 0.0373 0.5846
Schistosoma mansoni bromodomain containing protein 0.0074 0.0494 0.0561
Trypanosoma brucei glutaminyl cyclase, putative 0.0014 0.0009 0.0142
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0047 0.0066
Echinococcus granulosus dual specificity 0.0092 0.0637 0.0724
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0059 0.0373 0.0423
Loa Loa (eye worm) RNA binding protein 0.0065 0.0422 0.042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0066
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Onchocerca volvulus Protein ultraspiracle homolog 0.0072 0.0477 0.2217
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0422 0.042
Loa Loa (eye worm) steroid hormone receptor 0.0072 0.0477 0.0475
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0047 0.0051
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0072 0.0477 0.2217
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.003 0.0139 0.0157
Loa Loa (eye worm) DEAH box polypeptide 35 0.0065 0.0418 0.0416
Onchocerca volvulus 0.0014 0.0009 0.0033
Trypanosoma cruzi hypothetical protein 0.0065 0.0416 0.6522
Entamoeba histolytica hypothetical protein 0.0077 0.0518 0.0756
Brugia malayi Pre-SET motif family protein 0.0036 0.0187 0.0185
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0072 0.0477 0.0542
Loa Loa (eye worm) hypothetical protein 0.0072 0.0477 0.0475
Echinococcus multilocularis voltage dependent calcium channel 0.0116 0.0832 0.0946
Echinococcus multilocularis dna polymerase eta 0.0019 0.0047 0.0051
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0137
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0182 0.1365 0.1554
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0116 0.0832 0.0946
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0734
Toxoplasma gondii methionine aminopeptidase 0.0059 0.0373 0.7937
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0477 0.0542
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0312 0.0944
Entamoeba histolytica hypothetical protein 0.0077 0.0518 0.0756
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.0418 0.0609
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.1025 0.1023
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.5307 0.605
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0116 0.0832 0.0946
Trypanosoma brucei heat shock protein, putative 0.0065 0.0418 0.6561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.086 0.683 1
Plasmodium falciparum methionine aminopeptidase 2 0.0055 0.0342 0.7273
Brugia malayi MH2 domain containing protein 0.014 0.1025 0.1023
Toxoplasma gondii peptidase, M28 family protein 0.0014 0.0009 0.015
Entamoeba histolytica methionine aminopeptidase, putative 0.0055 0.0342 0.0497
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0055 0.0342 0.0497
Brugia malayi Bromodomain containing protein 0.0045 0.0258 0.0256
Loa Loa (eye worm) hypothetical protein 0.0072 0.0477 0.0475
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0245 0.1872 0.1871
Entamoeba histolytica protein kinase, putative 0.0092 0.0637 0.093
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.001
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0033 0.0163 0.0184
Brugia malayi RNA binding protein 0.0065 0.0422 0.042
Echinococcus multilocularis ecdysone induced protein 78C 0.0072 0.0477 0.0542
Echinococcus multilocularis jun protein 0.0182 0.1365 0.1554
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0065 0.0416 0.0607
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0071 0.0469 0.1423
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0422 0.0479
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0047 0.0051
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.003 0.0139 0.0201
Entamoeba histolytica hypothetical protein 0.0077 0.0518 0.0756
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0477 0.0542
Plasmodium vivax heat shock protein 90, putative 0.0027 0.011 0.2307
Schistosoma mansoni jumonji/arid domain-containing protein 0.0118 0.0848 0.0964
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0116 0.0832 0.0946
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.086 0.683 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.086 0.683 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0116 0.0832 0.0946
Schistosoma mansoni lipoxygenase 0.002 0.0054 0.0059
Brugia malayi nuclear hormone receptor 0.0034 0.017 0.0168
Leishmania major DNA polymerase kappa, putative 0.0019 0.0047 0.0707
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0071 0.0469 0.7357
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.0418 0.655
Onchocerca volvulus Glutaminyl cyclase homolog 0.0014 0.0009 0.0033
Schistosoma mansoni jun-related protein 0.0148 0.1089 0.124
Echinococcus granulosus ecdysone induced protein 78C 0.0072 0.0477 0.0542
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0376 0.0374
Brugia malayi hypothetical protein 0.0143 0.1049 0.1047
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0014 0.0009 0.0008
Echinococcus granulosus jun protein 0.0182 0.1365 0.1554
Echinococcus granulosus Ankyrin 0.0031 0.0149 0.0168
Brugia malayi photoreceptor-specific nuclear receptor 0.0072 0.0477 0.0475
Entamoeba histolytica protein kinase, putative 0.0092 0.0637 0.093
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0312 0.0453
Trypanosoma brucei heat shock protein, putative 0.0065 0.0418 0.6561
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0072 0.0477 0.0542
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0147 0.0677
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Loa Loa (eye worm) methionine aminopeptidase type I 0.0059 0.0373 0.0371
Toxoplasma gondii hypothetical protein 0.0021 0.0068 0.1413
Echinococcus granulosus voltage dependent calcium channel 0.0024 0.0092 0.0102
Trichomonas vaginalis set domain proteins, putative 0.0279 0.2144 0.3137
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0047 0.0066
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0145 0.3055
Trypanosoma brucei heat shock protein, putative 0.0065 0.0418 0.6561
Onchocerca volvulus Fxna peptidase homolog 0.0014 0.0009 0.0033
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0014 0.0009 0.0008
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0071 0.0469 0.0684
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.086 0.683 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0072 0.0477 0.0542
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Schistosoma mansoni heat shock protein 0.0065 0.0418 0.0475
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0047 0.0137
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Echinococcus granulosus proteasome prosome macropain 0.0071 0.0469 0.0532
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.003 0.0139 0.2161
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0047 0.0707
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0477 0.0475
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.017 0.0784
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0059 0.0373 0.5833
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0014 0.0009 0.0008
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0051
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Loa Loa (eye worm) hypothetical protein 0.0048 0.0287 0.0285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0477 0.0542
Loa Loa (eye worm) hypothetical protein 0.0048 0.0281 0.0279
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.042 0.3283 1
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.017 0.0192
Trichomonas vaginalis heat shock protein, putative 0.0027 0.011 0.0158
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0014 0.0009 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0637 0.0724
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0065 0.0416 0.0414
Brugia malayi Carboxylesterase family protein 0.0027 0.0112 0.011
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative 0.003 0.0139 0.2186
Echinococcus multilocularis heat shock protein 90 0.0052 0.0312 0.0353
Onchocerca volvulus 0.0177 0.1325 0.6168
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0052
Mycobacterium ulcerans methionine aminopeptidase 0.004 0.0217 0.0654
Brugia malayi nuclear receptor NHR-88 0.0072 0.0477 0.0475
Brugia malayi jmjC domain containing protein 0.0118 0.0848 0.0846
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.017 0.0192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.1252 1 1
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.003 0.0139 0.0201
Plasmodium falciparum endoplasmin, putative 0.004 0.0216 0.4586
Leishmania major hypothetical protein, conserved 0.0018 0.004 0.0602
Brugia malayi leucyl aminopeptidase 0.0014 0.0009 0.0007
Brugia malayi jmjC domain containing protein 0.0031 0.0145 0.0143
Schistosoma mansoni gliotactin 0.0027 0.0112 0.0126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0112 0.011
Trypanosoma cruzi glutaminyl cyclase, putative 0.0014 0.0009 0.011
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.004 0.0217 0.4596
Schistosoma mansoni hypothetical protein 0.0148 0.1089 0.124
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.011 0.0123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0254 0.0288
Loa Loa (eye worm) hypothetical protein 0.005 0.0299 0.0297
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0047 0.0737
Schistosoma mansoni nuclear hormone receptor 0.0034 0.017 0.0192
Brugia malayi Nuclear hormone receptor E75 0.0034 0.017 0.0168
Mycobacterium tuberculosis Carboxylesterase LipT 0.0027 0.0112 0.0336
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0071 0.0465 0.73
Loa Loa (eye worm) hypothetical protein 0.0177 0.1325 0.1323
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative 0.003 0.0139 0.2941
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0348 0.0394
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0204 0.318
Trichomonas vaginalis glutaminase, putative 0.0266 0.2039 0.2983
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0637 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0116 0.0832 0.0946
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0014 0.0009 0.0008
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0116 0.0832 0.0946
Entamoeba histolytica hypothetical protein 0.0077 0.0518 0.0756
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0055 0.0342 0.536
Onchocerca volvulus 0.002 0.0054 0.0243
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0019 0.0017
Echinococcus granulosus endoplasmin 0.0052 0.0312 0.0353
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0254 0.0288
Echinococcus granulosus tar DNA binding protein 0.0065 0.0422 0.0479
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0065 0.0416 0.0607
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0287 0.0285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0254 0.0288
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0027 0.0112 0.0126
Schistosoma mansoni heat shock protein 0.0027 0.011 0.0123
Brugia malayi Proteasome A-type and B-type family protein 0.0071 0.0469 0.0467
Toxoplasma gondii heat shock protein HSP90 0.0065 0.0418 0.8913
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0002 0.0032
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.046 0.0522
Brugia malayi jmjC domain containing protein 0.0031 0.0145 0.0143
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.0145 0.227
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.003 0.0139 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0737
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.0145 0.0163
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0051
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.003 0.0139 0.2941
Schistosoma mansoni phd/f-box containing protein 0.0031 0.0145 0.0163
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0054 0.0059
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.0145 0.0163
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0047 0.0959
Loa Loa (eye worm) hypothetical protein 0.0027 0.0112 0.011
Echinococcus granulosus heat shock protein 0.0065 0.0418 0.0475
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0059 0.0373 0.5833
Echinococcus granulosus heat shock protein 90 0.0052 0.0312 0.0353
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0055 0.0342 0.0497
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0518 0.0588
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0637 0.093
Giardia lamblia UBC3 0.003 0.0139 0.0201
Giardia lamblia DINP protein human, muc B family 0.0019 0.0047 0.0066
Schistosoma mansoni hypothetical protein 0.0018 0.004 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.086 0.683 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.017 0.0192
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0147 0.0145
Loa Loa (eye worm) hypothetical protein 0.0177 0.1324 0.1323
Trypanosoma brucei heat shock protein, putative 0.0065 0.0418 0.6561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.086 0.683 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0637 1
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0014 0.0009 0.0008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.017 0.0192
Echinococcus multilocularis heat shock protein 0.0065 0.0418 0.0475
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0047 0.0705
Plasmodium falciparum heat shock protein 90 0.0065 0.0418 0.8913
Leishmania major hypothetical protein, conserved 0.0031 0.0145 0.2245
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0203 0.0201
Echinococcus granulosus sentrin specific protease 8 0.0065 0.0416 0.0473
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.086 0.683 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.046 0.0522
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0072 0.0477 0.0542
Giardia lamblia Grp94/Hsp90 0.0052 0.0312 0.0453
Mycobacterium tuberculosis Conserved protein 0.0014 0.0009 0.0021
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.0002 0.0032
Brugia malayi Doublecortin family protein 0.002 0.0054 0.0052
Schistosoma mansoni loxhd1 0.002 0.0054 0.0059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0203 0.0201
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0203 0.0229
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0027 0.0112 0.0336
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.1025 0.1023
Schistosoma mansoni hypothetical protein 0.11 0.877 1
Echinococcus granulosus acetylcholinesterase 0.0159 0.1178 0.1341
Schistosoma mansoni rab6-interacting 0.002 0.0054 0.0059
Echinococcus multilocularis endoplasmin 0.0052 0.0312 0.0353
Loa Loa (eye worm) endoplasmin 0.0065 0.0418 0.0416
Echinococcus multilocularis heat shock protein 90 0.0065 0.0418 0.0475
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.017 0.0168
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.0002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0072 0.0477 0.0475
Schistosoma mansoni acetylcholinesterase 0.0027 0.0112 0.0126
Plasmodium falciparum HP12 protein homolog, putative 0.0019 0.0052 0.1062
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Schistosoma mansoni hypothetical protein 0.0024 0.0091 0.0101
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0312 0.0453
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0057 0.0063
Echinococcus granulosus muscleblind protein 0.0145 0.1067 0.1215
Leishmania major proteasome beta 5 subunit, putative 0.0071 0.0469 0.7349
Plasmodium vivax methionine aminopeptidase 1a, putative 0.004 0.0217 0.4596
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0054 0.0059
Onchocerca volvulus 0.0034 0.017 0.0784
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0159 0.1178 0.1341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0072 0.0477 0.0475
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0014 0.0009 0.0008
Schistosoma mansoni heat shock protein 0.0065 0.0418 0.0475
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0145 0.2245
Schistosoma mansoni coup transcription factor 0.0072 0.0477 0.0542
Brugia malayi nuclear receptor NHR-88 0.0034 0.017 0.0168
Brugia malayi hypothetical protein 0.0177 0.1325 0.1323
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0059 0.0373 0.5833
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.003 0.0139 0.0201
Loa Loa (eye worm) DR-78 0.0034 0.017 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0072 0.0477 0.0475
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1067 0.1215
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0019 0.0017
Echinococcus granulosus GPCR family 2 0.0015 0.0019 0.002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.042 0.3283 1
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Trypanosoma brucei heat shock protein, putative 0.0065 0.0418 0.6561
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0047 0.0066
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.0163 0.0183
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0072 0.0477 0.0542
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0422 0.042
Echinococcus granulosus lysine specific demethylase 5A 0.0118 0.0848 0.0964
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0737
Echinococcus granulosus zinc finger protein 0.0023 0.0081 0.009
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0376 0.0548
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0147 0.0145
Loa Loa (eye worm) carboxylesterase 0.0027 0.0112 0.011
Trypanosoma brucei unspecified product 0.0019 0.0047 0.0737
Leishmania major glutaminyl cyclase, putative 0.0014 0.0009 0.011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0182 0.1365 0.1554
Leishmania major hypothetical protein, conserved 0.0014 0.0009 0.011
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0055 0.0342 0.0497
Brugia malayi DnaJ domain containing protein 0.006 0.0376 0.0374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0254 0.0288
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0063 0.0061
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0055 0.0342 0.7273
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0418 0.655
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0477 0.0475
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0072 0.0477 0.0475
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0052 0.081
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0027 0.0112 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0072 0.0477 0.0475
Plasmodium vivax proteasome subunit beta type-5, putative 0.0071 0.0469 1
Brugia malayi hypothetical protein 0.0034 0.017 0.0168
Trypanosoma cruzi heat shock protein, putative 0.0027 0.011 0.1695
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0071 0.0469 0.7349
Echinococcus multilocularis dual specificity 0.0092 0.0637 0.0724
Onchocerca volvulus 0.0027 0.0112 0.0514
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0145 0.0143
Onchocerca volvulus 0.0027 0.0112 0.0514
Giardia lamblia Fructose-bisphosphate aldolase 0.086 0.683 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0054 0.1115
Echinococcus multilocularis sentrin specific protease 8 0.0065 0.0416 0.0473
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0047 0.0137
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0014 0.0009 0.0008
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0065 0.0416 0.0607
Schistosoma mansoni zinc finger protein 0.0023 0.0081 0.009
Loa Loa (eye worm) hypothetical protein 0.0072 0.0477 0.0475
Brugia malayi Nuclear hormone receptor E75 0.0034 0.017 0.0168
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.003 0.0139 0.0157
Plasmodium vivax SET domain protein, putative 0.0036 0.0187 0.3952
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0055 0.0342 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0422 0.0479
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0287 0.0285
Onchocerca volvulus 0.0027 0.0112 0.0514
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0014 0.0009 0.0008
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0339 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0072 0.0477 0.0475
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0339 0.0385
Toxoplasma gondii hypothetical protein 0.0019 0.0052 0.1062
Echinococcus multilocularis neuroligin 0.0027 0.0112 0.0126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.086 0.683 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.017 0.0168
Schistosoma mansoni netrin receptor unc5 0.0031 0.0147 0.0165
Trichomonas vaginalis heat shock protein, putative 0.004 0.0216 0.0314
Leishmania major DNA polymerase eta, putative 0.0019 0.0047 0.0707
Brugia malayi follicle stimulating hormone receptor 0.0271 0.2086 0.2084
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.0002 0.0032
Trypanosoma cruzi glutaminyl cyclase, putative 0.0014 0.0009 0.011
Schistosoma mansoni BC026374 protein (S09 family) 0.0027 0.0112 0.0126
Schistosoma mansoni RAR-like nuclear receptor 0.0072 0.0477 0.0542
Plasmodium vivax heat shock protein 86, putative 0.0065 0.0418 0.8913
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0072 0.0477 0.0542
Brugia malayi conserved hypotetical protein 0.0034 0.017 0.0168
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0149 0.0168
Brugia malayi Hsp90 protein 0.0027 0.011 0.0108
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0203 0.0229
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0066
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0055 0.0342 0.5345
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.004 0.0217 0.4596
Schistosoma mansoni hypothetical protein 0.0077 0.0518 0.0588
Schistosoma mansoni rab6-interacting 0.002 0.0054 0.0059
Onchocerca volvulus Fxna peptidase homolog 0.0014 0.0009 0.0033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0047 0.0705
Loa Loa (eye worm) hypothetical protein 0.0116 0.0832 0.083
Onchocerca volvulus Bile acid receptor homolog 0.0072 0.0477 0.2217
Echinococcus multilocularis voltage dependent calcium channel 0.0116 0.0832 0.0946
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0109 0.0122
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0203 0.0201
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0047 0.0136
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0312 0.0453
Echinococcus multilocularis zinc finger protein 0.0023 0.0081 0.009
Schistosoma mansoni polycystin 1-related 0.002 0.0054 0.0059
Trypanosoma brucei methionine aminopeptidase, putative 0.0059 0.0373 0.5846
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0254 0.0252
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0235 0.0266
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0737
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0091 0.0089
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0235 0.0266
Schistosoma mansoni Fxna peptidase (M28 family) 0.0014 0.0009 0.0008
Brugia malayi hypothetical protein 0.002 0.0054 0.0052
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0376 0.0427
Schistosoma mansoni neuroligin 3 (S09 family) 0.0027 0.0112 0.0126
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0418 0.6561
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0203 0.0229
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0071 0.0465 0.7291
Loa Loa (eye worm) hypothetical protein 0.0056 0.0348 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0477 0.0475
Leishmania major methionine aminopeptidase 2, putative 0.0055 0.0342 0.5345
Plasmodium falciparum SUMO-conjugating enzyme UBC9 0.003 0.0139 0.2941
Loa Loa (eye worm) hypothetical protein 0.0083 0.0564 0.0562
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.004 0.0217 0.0654
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0027 0.0112 0.0126
Loa Loa (eye worm) initiation factor 2-associated protein 0.0055 0.0342 0.034
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0027 0.0112 0.0161
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0072 0.0477 0.0542
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0066
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0477 0.0542
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0047 0.0959
Schistosoma mansoni steroid hormone receptor ad4bp 0.0072 0.0477 0.0542
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.017 0.0192
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0705
Loa Loa (eye worm) hypothetical protein 0.0038 0.0203 0.0201
Mycobacterium ulcerans glutaminase 0.0266 0.2039 0.6209
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.004 0.0217 0.6929
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Loa Loa (eye worm) carboxylesterase 0.0027 0.0112 0.011
Onchocerca volvulus 0.0036 0.0187 0.086
Brugia malayi nuclear receptor RXR 0.0034 0.017 0.0168
Schistosoma mansoni endoplasmin 0.0065 0.0418 0.0475
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0055 0.0342 0.536
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.017 0.0192
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0477 0.0475
Loa Loa (eye worm) hypothetical protein 0.0072 0.0477 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0477 0.0475
Trypanosoma brucei heat shock protein, putative 0.0065 0.0418 0.6561
Echinococcus granulosus histone lysine methyltransferase setb 0.0056 0.0348 0.0394
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0019 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0187 0.021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0203 0.0201
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Echinococcus granulosus dna polymerase eta 0.0019 0.0047 0.0051
Loa Loa (eye worm) hypothetical protein 0.0027 0.0112 0.011
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0312 0.0944
Echinococcus multilocularis phd:f box containing protein 0.0031 0.0145 0.0163
Trypanosoma cruzi ISWI complex protein 0.0018 0.004 0.0602
Echinococcus multilocularis carboxylesterase 5A 0.0159 0.1178 0.1341
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0059 0.0373 0.7937
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.017 0.0192
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.003 0.0139 0.2161
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0422 0.0479
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0422 0.042
Echinococcus granulosus heat shock protein 90 0.0065 0.0418 0.0475
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0418 0.0609
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0116 0.0832 0.0946
Schistosoma mansoni nuclear hormone receptor 0.0034 0.017 0.0192
Brugia malayi heat shock protein 90 0.0065 0.0418 0.0416
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.004 0.0217 0.0654
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0254 0.0288
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0047 0.0066
Brugia malayi Bromodomain containing protein 0.0088 0.0605 0.0603
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0065 0.0416 0.0473
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0116 0.083 0.0944
Plasmodium vivax heat shock protein, putative 0.0027 0.011 0.2307
Brugia malayi Pre-SET motif family protein 0.0245 0.1872 0.1871
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0518 0.0588
Loa Loa (eye worm) leucyl aminopeptidase 0.0014 0.0009 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0518 0.0588
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.004 0.0217 0.0654
Loa Loa (eye worm) hypothetical protein 0.0159 0.1178 0.1176
Brugia malayi glutaminase DH11.1 0.0266 0.2039 0.2038
Trypanosoma brucei heat shock protein, putative 0.0065 0.0418 0.6561
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Schistosoma mansoni jumonji/arid domain-containing protein 0.0118 0.0848 0.0964
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0038 0.0203 0.0201
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0312 0.4875
Echinococcus multilocularis sodium channel protein 0.0049 0.0293 0.0332
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.017 0.0192
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.6254 0.7131
Echinococcus multilocularis Ankyrin 0.0031 0.0149 0.0168
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0057 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0348 0.0394
Loa Loa (eye worm) hypothetical protein 0.0027 0.0112 0.011
Brugia malayi nuclear hormone receptor 0.0072 0.0477 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0072 0.0477 0.0475
Loa Loa (eye worm) doublecortin family protein 0.002 0.0054 0.0052
Trichomonas vaginalis endoplasmin, putative 0.004 0.0216 0.0314
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0254 0.0288
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0047 0.0707
Schistosoma mansoni SET domain protein 0.0014 0.0007 0.0006
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0057 0.0063
Onchocerca volvulus Fxna peptidase homolog 0.0014 0.0009 0.0033
Schistosoma mansoni protein phosphatase 2C 0.0031 0.0145 0.0163
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0116 0.0832 0.083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0477 0.0542
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0072 0.0477 0.0475
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.017 0.0168
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0033 0.0163 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0072 0.0477 0.0475
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.017 0.0192
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0072 0.0477 0.0542
Echinococcus granulosus microtubule associated protein 2 0.0671 0.5307 0.605
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0312 0.0944
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0045
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0116 0.083 0.0944
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Brugia malayi Endoplasmin precursor 0.0065 0.0418 0.0416
Brugia malayi initiation factor 2-associated protein. 0.0055 0.0342 0.034
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0071 0.0469 0.0467
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.011 0.0123
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0418 0.655
Loa Loa (eye worm) hypothetical protein 0.0145 0.1067 0.1065
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0072 0.0477 0.0542
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.017 0.0168
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.004 0.0217 0.0245
Trichomonas vaginalis spcc417.12 protein, putative 0.0027 0.0112 0.0161
Trypanosoma cruzi ISWI complex protein 0.0018 0.004 0.0602
Echinococcus multilocularis GPCR, family 2 0.0015 0.0019 0.002
Schistosoma mansoni DNA polymerase eta 0.0019 0.0047 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0072 0.0477 0.0475
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0014 0.0009 0.0008
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.0145 0.0163
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.0145 0.0163
Brugia malayi Protein kinase domain containing protein 0.0032 0.0151 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0477 0.0475
Brugia malayi Probable ATP-dependent helicase DHX35 0.0065 0.0418 0.0416
Schistosoma mansoni endoplasmin 0.0065 0.0418 0.0475
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0054 0.0059
Brugia malayi nuclear receptor NHR-67 0.0034 0.017 0.0168
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0054 0.0059
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.0145 0.0163
Echinococcus granulosus voltage dependent calcium channel 0.0116 0.0832 0.0946
Echinococcus multilocularis methionyl aminopeptidase 2 0.0055 0.0342 0.0387
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0045
Brugia malayi bZIP transcription factor family protein 0.0182 0.1365 0.1363
Entamoeba histolytica hypothetical protein 0.0092 0.0637 0.093
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.0418 0.8913
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Toxoplasma gondii transporter, cation channel family protein 0.0024 0.0092 0.192
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0059 0.0373 0.0423
Echinococcus multilocularis thyroid hormone receptor alpha 0.0072 0.0477 0.0542
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.009
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0055 0.0342 0.0497
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0147 0.0165
Brugia malayi Carboxylesterase family protein 0.0027 0.0112 0.011
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0071 0.0469 0.7349
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0027 0.0112 0.0126
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.0418 0.655
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0047 0.0051
Brugia malayi hypothetical protein 0.002 0.0054 0.0052
Onchocerca volvulus 0.0034 0.017 0.0784
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0072 0.0477 0.0475
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Brugia malayi steroid hormone receptor 0.0072 0.0477 0.0475
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0145
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0637 0.0635
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0019 0.0017
Brugia malayi ube2i2 protein 0.003 0.0139 0.0137
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0027 0.0112 0.0126
Echinococcus multilocularis proteasome (prosome, macropain) 0.0071 0.0469 0.0532
Treponema pallidum methionine aminopeptidase (map) 0.004 0.0217 0.0314
Brugia malayi Carboxylesterase family protein 0.0027 0.0112 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0707
Brugia malayi Steroid receptor seven-up type 2 0.0072 0.0477 0.0475
Schistosoma mansoni jumonji domain containing protein 0.0031 0.0145 0.0163
Echinococcus multilocularis FTZ F1 alpha 0.0072 0.0477 0.0542
Brugia malayi hypothetical protein 0.0077 0.0518 0.0516
Chlamydia trachomatis methionine aminopeptidase 0.004 0.0217 1
Onchocerca volvulus 0.0027 0.0112 0.0514
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0072 0.0477 0.0475
Toxoplasma gondii proteasome subunit beta type, putative 0.0071 0.0469 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.016 0.1184 0.1348
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.004 0.0217 0.0245
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.017 0.0168
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.017 0.0168
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0055 0.0342 0.5345
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0254 0.0288
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0168 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0707
Echinococcus multilocularis lysine specific demethylase 5A 0.0116 0.083 0.0944
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0071 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0145 0.1067 0.1065
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0203 0.0201
Plasmodium vivax methionine aminopeptidase 2, putative 0.0055 0.0342 0.7273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.086 0.683 1
Brugia malayi FXNA 0.0014 0.0009 0.0007
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0047 0.0051
Echinococcus granulosus FTZ F1 alpha 0.0072 0.0477 0.0542
Schistosoma mansoni SET domain protein 0.0033 0.0163 0.0184
Trypanosoma brucei ISWI complex protein 0.0018 0.004 0.0632
Loa Loa (eye worm) hypothetical protein 0.0031 0.0149 0.0147
Echinococcus multilocularis BC026374 protein (S09 family) 0.0027 0.0112 0.0126
Plasmodium falciparum proteasome subunit beta type-5 0.0071 0.0469 1
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.11 0.877 1
Loa Loa (eye worm) glutaminase 0.0266 0.2039 0.2038
Mycobacterium ulcerans carboxylesterase, LipT 0.0027 0.0112 0.0336
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0065 0.0416 0.0607
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0047 0.0136
Loa Loa (eye worm) carboxylesterase 0.0159 0.1178 0.1176
Loa Loa (eye worm) glutaminase 2 0.0266 0.2039 0.2038
Plasmodium vivax endoplasmin, putative 0.0065 0.0418 0.8913
Echinococcus granulosus nuclear factor of activated T cells 5 0.016 0.1184 0.1348
Trypanosoma brucei heat shock protein, putative 0.0065 0.0418 0.6561
Loa Loa (eye worm) hypothetical protein 0.0065 0.0418 0.0416
Leishmania major heat shock protein 83-1 0.0065 0.0418 0.655
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0014 0.0009 0.0021
Brugia malayi Methionine aminopeptidase protein type I 0.0059 0.0373 0.0371
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0071 0.0469 0.0684
Giardia lamblia Methionine aminopeptidase 0.0055 0.0342 0.0497
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0116 0.0832 0.0946
Loa Loa (eye worm) hypothetical protein 0.0027 0.0112 0.011
Mycobacterium ulcerans methionine aminopeptidase MapB 0.004 0.0217 0.0654
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.0145 0.0163
Brugia malayi nuclear receptor RXR 0.0038 0.0203 0.0201
Schistosoma mansoni voltage-gated cation channel 0.0116 0.0832 0.0946
Loa Loa (eye worm) ube2i2 protein 0.003 0.0139 0.0137
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.017 0.0192
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.017 0.0192
Brugia malayi jmjC domain containing protein 0.0031 0.0145 0.0143
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.0145 0.0163
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0014 0.0009 0.0021
Echinococcus granulosus acetylcholinesterase 0.0159 0.1178 0.1341
Leishmania major hypothetical protein, conserved 0.0019 0.0052 0.078
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0477 0.0542
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Onchocerca volvulus 0.0027 0.0112 0.0514
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.017 0.0192
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0047 0.1445
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0072 0.0477 0.0475
Plasmodium vivax JmjC domain containing protein 0.0031 0.0145 0.3055
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0187 0.3952
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0477 0.0475
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.011 0.1722
Schistosoma mansoni hypothetical protein 0.006 0.0376 0.0427
Mycobacterium ulcerans hypothetical protein 0.0014 0.0009 0.0021
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.017 0.0192
Toxoplasma gondii exonuclease III APE 0.0019 0.0047 0.0959
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0637 1
Brugia malayi Carboxylesterase family protein 0.0027 0.0112 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0707
Loa Loa (eye worm) hypothetical protein 0.0091 0.0633 0.0632
Echinococcus granulosus dna polymerase kappa 0.0019 0.0047 0.0051
Echinococcus multilocularis acetylcholinesterase 0.0159 0.1178 0.1341
Brugia malayi Carboxylesterase family protein 0.0159 0.1178 0.1176
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0477 0.0542
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.002
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0312 0.4875
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0147 0.0165
Echinococcus granulosus neuroligin 0.0027 0.0112 0.0126
Leishmania major heat shock protein, putative 0.0027 0.011 0.1695
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0052 0.078
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0418 0.0609
Schistosoma mansoni retinoic acid receptor RXR 0.0072 0.0477 0.0542
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0059 0.0373 0.5846
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.0145 0.3055
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.11 0.877 0.877
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0054 0.1115
Schistosoma mansoni lipoxygenase 0.0055 0.0339 0.0385
Brugia malayi hypothetical protein 0.0038 0.0203 0.0201
Toxoplasma gondii hypothetical protein 0.0014 0.0009 0.015
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0147 0.0165
Brugia malayi jmjC domain containing protein 0.0116 0.083 0.0828
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0422 0.0479
Echinococcus granulosus death domain containing protein 0.0031 0.0147 0.0165
Onchocerca volvulus 0.0072 0.0477 0.2217
Mycobacterium ulcerans proteasome PrcB 0.0071 0.0469 0.1423
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0737
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.011 0.0502
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0418 0.6561
Schistosoma mansoni hypothetical protein 0.0033 0.0163 0.0184
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.0002 0.0032
Echinococcus multilocularis muscleblind protein 0.0145 0.1067 0.1215

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.49 uM PUBCHEM_BIOASSAY: SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2073, AID2091, AID2093, AID2489] ChEMBL. No reference
IC50 (functional) = 6.04 uM PUBCHEM_BIOASSAY: SAR analysis of SUMOylation using HTRF in an in-Vitro dose response assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2006, AID2011, AID2018, AID2069, AID2658] ChEMBL. No reference
IC50 (functional) > 56.8 uM PUBCHEM_BIOASSAY: SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2073, AID2091, AID2093, AID434980] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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