Detailed information for compound 1577818

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.53 | Formula: C25H29N5O2
  • H donors: 1 H acceptors: 2 LogP: 2.82 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CN(C(=O)c1cn(c2c1ccc(c2)c1c[nH]nc1)CCN(C)C)C
  • InChi: 1S/C25H29N5O2/c1-28(2)10-11-30-17-23(22-9-8-19(13-24(22)30)20-14-26-27-15-20)25(31)29(3)16-18-6-5-7-21(12-18)32-4/h5-9,12-15,17H,10-11,16H2,1-4H3,(H,26,27)
  • InChiKey: OCYSOXLZJBAKGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens Rho-associated, coiled-coil containing protein kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/PKA protein kinase 0.0109 0.0499 0.0499
Echinococcus multilocularis casein kinase I delta 0.0105 0.0459 0.0636
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0152 0.0897 0.4126
Brugia malayi Protein kinase domain containing protein 0.0547 0.4606 0.4606
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0113 0.0536 0.0536
Echinococcus multilocularis ephrin type A receptor 4 A 0.0111 0.0514 0.0713
Echinococcus multilocularis serine:threonine protein kinase 3 0.0249 0.1812 0.2512
Echinococcus granulosus Vam6:Vps39 protein 0.0109 0.0497 0.0565
Brugia malayi ephrin receptor 1 precursor 0.0078 0.0205 0.0205
Entamoeba histolytica protein kinase, putative 0.0062 0.0054 0.0184
Echinococcus multilocularis tyrosine protein kinase Src64B 0.023 0.1631 0.2261
Schistosoma mansoni protein kinase 0.0105 0.0459 0.0902
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.023 0.1631 0.2261
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0086 0.0283 0.0336
Schistosoma mansoni rap gtpase-activating protein 0.0109 0.0497 0.0977
Leishmania major protein kinase, putative 0.0149 0.087 0.3787
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0096 0.0375 0.0375
Brugia malayi hypothetical protein 0.0109 0.0497 0.0497
Echinococcus granulosus protein kinase C gamma type 0.0189 0.1246 0.1416
Brugia malayi Protein kinase domain containing protein 0.008 0.0226 0.0226
Schistosoma mansoni sterol O-acyltransferase 1 0.0121 0.061 0.1198
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0115 0.0552 0.0552
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0231 0.164 0.164
Mycobacterium ulcerans hypothetical protein 0.0099 0.0405 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.1414 0.2779
Schistosoma mansoni growth factor receptor-bound protein 0.0098 0.0393 0.0773
Trypanosoma cruzi casein kinase II, putative 0.0096 0.0381 0.1205
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0282 0.112
Echinococcus granulosus ephrin type A receptor 4 A 0.0111 0.0514 0.0584
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0149 0.0872 0.0872
Loa Loa (eye worm) TK/FER protein kinase 0.0104 0.0453 0.0453
Schistosoma mansoni protein kinase 0.0083 0.0252 0.0496
Brugia malayi Cam kinase protein 1 0.0097 0.0388 0.0388
Echinococcus granulosus twitchin 0.0146 0.0843 0.0958
Toxoplasma gondii AGC kinase 0.0109 0.0499 0.1629
Echinococcus multilocularis mitogen activated protein kinase 11 0.0154 0.092 0.1275
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0109 0.0497 0.0565
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0583 0.1146
Echinococcus granulosus Glutaredoxin protein 5 0.012 0.0606 0.0689
Echinococcus multilocularis CDC7 cell division cycle 7 0.0086 0.0287 0.0397
Onchocerca volvulus 0.0104 0.0453 0.0761
Echinococcus granulosus Immunoglobulin 0.0091 0.0331 0.0376
Brugia malayi Protein kinase domain containing protein 0.0149 0.087 0.087
Toxoplasma gondii AGC kinase 0.0109 0.0499 0.1629
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0196 0.1317 0.1826
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0109 0.0499 0.1873
Trichomonas vaginalis AGC family protein kinase 0.0149 0.0872 0.4032
Schistosoma mansoni serine/threonine-protein kinase 0.016 0.0979 0.1923
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0078 0.0211 0.024
Entamoeba histolytica protein kinase domain containing protein 0.0134 0.0736 0.2497
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0109 0.0499 0.0499
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0459 0.0902
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0381 0.1611
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0124 0.0642 0.1261
Echinococcus multilocularis serine:threonine protein kinase 0.011 0.0509 0.0706
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0146 0.0844 0.0844
Loa Loa (eye worm) TK protein kinase 0.0282 0.2119 0.2119
Schistosoma mansoni cell adhesion molecule 0.006 0.0039 0.0076
Echinococcus granulosus hypothetical protein 0.0118 0.0579 0.0658
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0096 0.0375 0.0375
Onchocerca volvulus 0.0086 0.0287 0.0481
Echinococcus granulosus sterol O acyltransferase 1 0.0121 0.061 0.0693
Schistosoma mansoni nephrin 0.013 0.0696 0.1367
Brugia malayi Temporarily assigned gene name protein 59 0.0126 0.0655 0.0655
Echinococcus multilocularis mitogen activated protein kinase 14 0.0154 0.092 0.1275
Echinococcus granulosus NDR protein kinase 0.0149 0.0872 0.0991
Schistosoma mansoni serine/threonine protein kinase 0.018 0.1163 0.2286
Loa Loa (eye worm) TK/ABL protein kinase 0.0306 0.2347 0.2347
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0149 0.087 0.3972
Brugia malayi Protein kinase domain containing protein 0.0118 0.0583 0.0583
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0552 0.2452
Echinococcus granulosus tyrosine protein kinase Fps85D 0.04 0.3223 0.3662
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0118 0.0583 0.0583
Echinococcus granulosus tyrosine protein kinase Fyn 0.023 0.1631 0.1854
Echinococcus multilocularis growth factor receptor bound protein 2 0.0096 0.0375 0.052
Echinococcus granulosus nervana 2 0.012 0.0606 0.0689
Schistosoma mansoni tyrosine kinase 0.0093 0.0349 0.0685
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0256 0.188 0.188
Echinococcus multilocularis protein kinase c iota type 0.027 0.2011 0.2788
Echinococcus multilocularis casein kinase i 0.0105 0.0459 0.0636
Echinococcus multilocularis nervana 2 0.012 0.0606 0.084
Echinococcus multilocularis NCK adaptor protein 0.0098 0.0393 0.0545
Trichomonas vaginalis AGC family protein kinase 0.0278 0.2083 1
Loa Loa (eye worm) TK/FER protein kinase 0.0104 0.0453 0.0453
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0159 0.0965 0.1338
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0081 0.0232 0.0063
Entamoeba histolytica PH domain containing protein kinase, putative 0.0118 0.0581 0.197
Plasmodium falciparum glycogen synthase kinase 3 0.0124 0.0642 0.6303
Echinococcus granulosus N chimaerin 0.0097 0.0382 0.0434
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0499 0.0981
Schistosoma mansoni vam6/vps39 related 0.0109 0.0497 0.0977
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0114 0.0224
Echinococcus granulosus NCK adaptor protein 0.0096 0.0375 0.0426
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0149 0.087 0.087
Echinococcus granulosus fibroblast growth factor receptor 4 0.0241 0.174 0.1977
Toxoplasma gondii aurora kinase 0.0086 0.0282 0.0418
Giardia lamblia Kinase, STE STE20 0.0083 0.0252 0.0155
Loa Loa (eye worm) hypothetical protein 0.006 0.0039 0.0039
Trypanosoma cruzi casein kinase, putative 0.0105 0.0459 0.1647
Loa Loa (eye worm) AGC/NDR protein kinase 0.0149 0.0872 0.0872
Echinococcus multilocularis serine:threonine protein kinase N2 0.0126 0.0661 0.0916
Echinococcus granulosus defective proboscis extension response 0.0091 0.0331 0.0376
Brugia malayi Protein kinase domain containing protein 0.0104 0.0453 0.0453
Brugia malayi Fibronectin type III domain containing protein 0.0106 0.0474 0.0474
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0209 0.1439 0.1635
Trichomonas vaginalis CAMK family protein kinase 0.0262 0.1935 0.9269
Loa Loa (eye worm) CAMK/PKD protein kinase 0.017 0.1072 0.1072
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.023 0.1631 0.2261
Loa Loa (eye worm) hypothetical protein 0.0106 0.0474 0.0474
Loa Loa (eye worm) thyroid receptor interactor 0.0114 0.0545 0.0545
Echinococcus multilocularis calcium activated potassium channel 0.013 0.0698 0.0968
Entamoeba histolytica protein kinase , putative 0.0086 0.0282 0.0956
Giardia lamblia Kinase, CAMK CAMKL 0.0086 0.0283 0.0337
Echinococcus multilocularis death associated protein kinase 1 0.0825 0.7214 1
Trichomonas vaginalis STE family protein kinase 0.0132 0.071 0.3232
Loa Loa (eye worm) hypothetical protein 0.0097 0.0388 0.0388
Plasmodium falciparum serine/threonine protein kinase, putative 0.0086 0.0282 0.1086
Brugia malayi serine/threonine protein kinase 6 0.0086 0.0282 0.0282
Echinococcus multilocularis casein kinase ii subunit alpha 0.0096 0.0381 0.0528
Schistosoma mansoni serine/threonine protein kinase 0.0464 0.3822 0.7511
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.006 0.0039 0.0054
Brugia malayi Protein kinase domain containing protein 0.0282 0.2119 0.2119
Brugia malayi SH2 domain containing protein 0.04 0.3223 0.3223
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0154 0.092 0.4255
Leishmania major protein kinase A catalytic subunit 0.0109 0.0499 0.1624
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0134 0.0736 0.0736
Entamoeba histolytica protein kinase, putative 0.0278 0.2083 0.7068
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0068 0.0114 0.0129
Echinococcus granulosus contactin 0.006 0.0039 0.0044
Toxoplasma gondii histone kinase SNF1, putative 0.0086 0.0283 0.0427
Echinococcus multilocularis casein kinase I alpha 0.0105 0.0459 0.0636
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0086 0.0282 0.2581
Schistosoma mansoni cell adhesion molecule 0.0127 0.0671 0.1318
Giardia lamblia Kinase, CMGC MAPK 0.0081 0.0232 0.0034
Loa Loa (eye worm) TK/EGFR protein kinase 0.0599 0.5089 0.5089
Schistosoma mansoni tyrosine kinase 0.0312 0.2402 0.4721
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0195 0.13 0.13
Brugia malayi Immunoglobulin I-set domain containing protein 0.0265 0.1962 0.1962
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0187 0.1228 0.1228
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0097 0.0382 0.0529
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0422 0.3429 0.4754
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0109 0.0497 0.1863
Trichomonas vaginalis CMGC family protein kinase 0.0086 0.0287 0.1145
Loa Loa (eye worm) hypothetical protein 0.0106 0.0474 0.0474
Trichomonas vaginalis AGC family protein kinase 0.0278 0.2083 1
Entamoeba histolytica protein kinase, putative 0.0087 0.0291 0.0987
Entamoeba histolytica protein kinase, putative 0.0149 0.0872 0.296
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0283 0.0557
Echinococcus multilocularis activin receptor type 0.0079 0.0221 0.0306
Plasmodium falciparum protein serine/threonine kinase-1 0.0149 0.087 0.9605
Echinococcus granulosus tyrosine protein kinase Srms 0.0501 0.4176 0.4745
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0215 0.1496 0.2074
Loa Loa (eye worm) hypothetical protein 0.0135 0.0744 0.0744
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0097 0.0382 0.075
Trichomonas vaginalis CAMK family protein kinase 0.0262 0.1935 0.9269
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.014 0.0789 0.1094
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0552 0.2452
Echinococcus multilocularis dual specificity 0.0134 0.0736 0.102
Schistosoma mansoni tyrosine kinase 0.0079 0.0216 0.0425
Schistosoma mansoni protein kinase 0.0148 0.0865 0.17
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0109 0.0499 0.1629
Loa Loa (eye worm) hypothetical protein 0.0112 0.0528 0.0528
Schistosoma mansoni serine/threonine kinase 0.0149 0.0872 0.1714
Echinococcus multilocularis 0.0148 0.0865 0.12
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0282 0.0553
Echinococcus multilocularis tyrosine kinase 0.0104 0.0453 0.0628
Leishmania major protein kinase A catalytic subunit isoform 2 0.0109 0.0499 0.1624
Schistosoma mansoni protein kinase 0.0356 0.2816 0.5533
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0231 0.164 0.1864
Schistosoma mansoni tyrosine kinase 0.0256 0.1879 0.3693
Echinococcus granulosus roundabout 2 0.0151 0.0893 0.1014
Schistosoma mansoni tyrosine kinase 0.0241 0.174 0.3419
Trichomonas vaginalis CMGC family protein kinase 0.0086 0.0287 0.1145
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0115 0.0552 0.0552
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0068 0.0114 0.0129
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0118 0.0583 0.1946
Brugia malayi Casein kinase II, alpha chain 0.0096 0.0381 0.0381
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.014 0.0788 0.0896
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0736 0.336
Entamoeba histolytica cell division protein kinase 2, putative 0.0115 0.0552 0.1872
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0083 0.0252 0.0287
Echinococcus granulosus tyrosine protein kinase Src64B 0.023 0.1631 0.1854
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0078 0.0211 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0698 0.1372
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.1628 0.3199
Onchocerca volvulus 0.0189 0.1245 0.2091
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0097 0.0388 0.386
Echinococcus granulosus protein kinase shaggy 0.0124 0.0642 0.0729
Entamoeba histolytica protein kinase, putative 0.0086 0.0282 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0152 0.0897 0.1019
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0124 0.0642 0.0642
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0388 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0262 0.1935 0.9269
Brugia malayi Variant SH3 domain containing protein 0.0097 0.0382 0.0382
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0209 0.1439 0.1635
Trypanosoma cruzi polo-like protein kinase, putative 0.0262 0.1935 1
Entamoeba histolytica protein kinase domain containing protein 0.0124 0.0642 0.2178
Trichomonas vaginalis AGC family protein kinase 0.0278 0.2083 1
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0078 0.0211 0.0211
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Echinococcus granulosus casein kinase I alpha 0.0105 0.0459 0.0522
Loa Loa (eye worm) AUR protein kinase 0.0086 0.0282 0.0282
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0071 0.0142 0.0142
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0083 0.0252 0.0287
Plasmodium falciparum calcium-dependent protein kinase 4 0.0097 0.0388 0.2623
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0509 0.2241
Echinococcus multilocularis raf serine:threonine protein kinase 0.0089 0.0312 0.0432
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0097 0.0388 0.386
Loa Loa (eye worm) hypothetical protein 0.0087 0.0292 0.0292
Echinococcus multilocularis protein kinase c epsilon type 0.0191 0.1266 0.1755
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.008 0.0226 0.0106
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.018 0.1163 0.1613
Trichomonas vaginalis CK1 family protein kinase 0.0105 0.0459 0.1995
Loa Loa (eye worm) TK/FER protein kinase 0.04 0.3223 0.3223
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0091 0.0331 0.065
Echinococcus multilocularis roundabout 2 0.006 0.0039 0.0054
Schistosoma mansoni ephrin receptor 0.0064 0.0073 0.0143
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0736 0.336
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0159 0.0965 0.1097
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0621 0.2793
Loa Loa (eye worm) hypothetical protein 0.0104 0.0453 0.0453
Echinococcus multilocularis tyrosine protein kinase Srms 0.019 0.1256 0.1741
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0096 0.0381 0.378
Brugia malayi Protein kinase domain containing protein 0.0188 0.1241 0.1241
Echinococcus multilocularis mitogen activated protein kinase 11 0.0154 0.092 0.1275
Echinococcus multilocularis dual specificity 0.0134 0.0736 0.102
Loa Loa (eye worm) hypothetical protein 0.0091 0.0331 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.1613 0.3169
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0097 0.0388 0.0441
Brugia malayi SH2 domain containing protein 0.0104 0.0453 0.0453
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.1266 0.2487
Plasmodium vivax glycogen synthase kinase 3, putative 0.0124 0.0642 0.6923
Schistosoma mansoni tyrosine kinase 0.0144 0.0828 0.1627
Schistosoma mansoni titin 0.007 0.0133 0.0261
Echinococcus multilocularis 0.0118 0.0579 0.0803
Trypanosoma cruzi cdc2-related kinase 1 0.0115 0.0552 0.2171
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0109 0.0499 0.0567
Brugia malayi hypothetical protein 0.0106 0.0474 0.0474
Echinococcus multilocularis cGMP dependent protein kinase 1 0.013 0.0696 0.0965
Loa Loa (eye worm) TK/INSR protein kinase 0.044 0.3605 0.3605
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0091 0.0331 0.0459
Brugia malayi RhoGAP domain containing protein 0.0097 0.0382 0.0382
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0097 0.0382 0.0382
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0081 0.0232 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0552 0.2452
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0081 0.0232 0.0359
Loa Loa (eye worm) hypothetical protein 0.0109 0.0499 0.0499
Giardia lamblia Kinase, NEK 0.0132 0.071 0.2834
Trichomonas vaginalis AGC family protein kinase 0.0149 0.0872 0.4032
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0081 0.024 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0698 0.1372
Plasmodium vivax casein kinase 1, putative 0.0105 0.0459 0.4721
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0256 0.188 0.2606
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0086 0.0283 0.0365
Brugia malayi Protein kinase domain containing protein 0.0149 0.0872 0.0872
Brugia malayi Protein kinase domain 0.0083 0.0252 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0872 0.1714
Echinococcus multilocularis serine:threonine protein kinase 0.011 0.0509 0.0706
Onchocerca volvulus 0.0073 0.0162 0.0272
Schistosoma mansoni serine/threonine kinase 0.021 0.1448 0.2846
Brugia malayi Protein kinase domain containing protein 0.0104 0.0453 0.0453
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.021 0.1448 0.1448
Brugia malayi Protein kinase domain containing protein 0.0187 0.1228 0.1228
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0109 0.0499 0.1873
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0081 0.0232 0.0359
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0306 0.2347 0.3253
Schistosoma mansoni serine/threonine protein kinase 0.0247 0.1796 0.3528
Echinococcus multilocularis sterol O acyltransferase 1 0.0121 0.061 0.0845
Brugia malayi Protein kinase domain containing protein 0.0583 0.4946 0.4946
Echinococcus granulosus insulin receptor 0.044 0.3605 0.4096
Trichomonas vaginalis AGC family protein kinase 0.0278 0.2083 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0128 0.0675 0.0675
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0115 0.0552 0.1931
Giardia lamblia Kinase, STE STE20 0.0081 0.024 0.0083
Entamoeba histolytica serine/threonine protein kinase, putative 0.0086 0.0283 0.0961
Entamoeba histolytica protein kinase, putative 0.0068 0.0114 0.0386
Giardia lamblia Kinase, AGC PKA 0.0109 0.0499 0.1599
Entamoeba histolytica protein kinase, putative 0.007 0.0136 0.0461
Echinococcus multilocularis serine threonine protein kinase 0.0189 0.1246 0.1727
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0144 0.0828 0.1627
Echinococcus granulosus growth factor receptor bound protein 2 0.0098 0.0393 0.0447
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0211 0.1454 0.1454
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0132 0.071 0.2805
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0104 0.0453 0.1536
Echinococcus granulosus calcium dependent protein kinase 0.0066 0.0097 0.011
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0039 0.0039
Echinococcus multilocularis hypothetical protein 0.0099 0.0407 0.0565
Brugia malayi serine/threonine-protein kinase plk-2 0.0262 0.1935 0.1935
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0269 0.2002 0.2002
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0381 0.1611
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0111 0.0518 0.0588
Giardia lamblia Kinase, AGC AKT 0.0113 0.0536 0.1815
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0149 0.0872 0.1209
Brugia malayi Protein kinase domain containing protein 0.0188 0.1236 0.1236
Brugia malayi C1-like domain containing protein 0.0211 0.1454 0.1454
Echinococcus granulosus titin 0.007 0.0133 0.0151
Loa Loa (eye worm) hypothetical protein 0.018 0.1163 0.1163
Onchocerca volvulus 0.0074 0.0168 0.0283
Trichomonas vaginalis AGC family protein kinase 0.0149 0.0872 0.4032
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0158 0.0962 0.0962
Trypanosoma brucei cdc2-related kinase 3 0.0115 0.0552 0.1778
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0356 0.2816 0.2816
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0621 0.2793
Echinococcus granulosus mitogen activated protein kinase 0.0081 0.0232 0.0263
Schistosoma mansoni protein kinase 0.0086 0.0282 0.0553
Echinococcus granulosus tyrosine protein kinase HCK 0.0134 0.0733 0.0833
Toxoplasma gondii AGC kinase 0.0269 0.2002 1
Trypanosoma brucei aurora B kinase 0.0086 0.0282 0.0327
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0109 0.0499 0.4234
Schistosoma mansoni tyrosine kinase 0.0366 0.2907 0.5712
Trypanosoma brucei rac serine-threonine kinase, putative 0.0278 0.2083 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0097 0.0388 0.2623
Loa Loa (eye worm) TK/FER protein kinase 0.0104 0.0453 0.0453
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0404 0.3264 0.4525
Echinococcus multilocularis tyrosine protein kinase 0.0282 0.2119 0.2938
Leishmania major casein kinase, putative 0.0105 0.0459 0.1391
Onchocerca volvulus 0.0351 0.2766 0.4647
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Echinococcus multilocularis tyrosine protein kinase Fyn 0.019 0.1256 0.1741
Echinococcus multilocularis tyrosine protein kinase Fgr 0.023 0.1631 0.2261
Schistosoma mansoni protein kinase 0.0422 0.3429 0.6738
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0086 0.0283 0.0651
Leishmania major protein kinase, putative 0.0097 0.0388 0.0975
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0068 0.0114 0.0158
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0109 0.0499 0.0567
Schistosoma mansoni hypothetical protein 0.0099 0.0407 0.08
Echinococcus granulosus CDC7 cell division cycle 7 0.0086 0.0287 0.0326
Brugia malayi Protein kinase domain containing protein 0.0104 0.0453 0.0453
Loa Loa (eye worm) TK protein kinase 0.0265 0.1962 0.1962
Loa Loa (eye worm) hypothetical protein 0.0116 0.0563 0.0563
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0262 0.1935 0.1935
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0109 0.0497 0.1863
Loa Loa (eye worm) TK/FAK protein kinase 0.0547 0.4606 0.4606
Giardia lamblia Kinase, CK1 Casein kinase 0.0105 0.0459 0.1365
Loa Loa (eye worm) TK/FER protein kinase 0.0104 0.0453 0.0453
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0086 0.0283 0.0651
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0287 0.0563
Echinococcus multilocularis expressed protein 0.008 0.0226 0.0313
Entamoeba histolytica protein kinase, putative 0.008 0.0226 0.0766
Trichomonas vaginalis CAMK family protein kinase 0.021 0.1448 0.687
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0456 0.3748 0.5195
Echinococcus granulosus expressed protein 0.008 0.0226 0.0257
Giardia lamblia Aurora kinase 0.0086 0.0282 0.0327
Echinococcus multilocularis nervana 2 0.012 0.0606 0.084
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.087 0.1709
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0196 0.1317 0.1497
Echinococcus granulosus casein kinase I delta 0.0105 0.0459 0.0522
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0518 0.2284
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0083 0.0252 0.035
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0231 0.164 0.1864
Brugia malayi Protein kinase domain containing protein 0.0104 0.0453 0.0453
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.013 0.0696 0.2726
Onchocerca volvulus 0.0104 0.0453 0.0761
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0086 0.0283 0.0393
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.008 0.0226 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0109 0.0499 0.2192
Brugia malayi Protein kinase domain containing protein 0.021 0.1448 0.1448
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0081 0.0232 0.0359
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1123 1 1
Trypanosoma brucei cdc2-related kinase 1 0.0115 0.0552 0.1778
Plasmodium vivax serine/threonine kinase-1, putative 0.0149 0.087 0.9671
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0995 0.8801 1
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0499 0.0981
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0965 0.1897
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.087 0.1709
Trichomonas vaginalis CMGC family protein kinase 0.0086 0.0287 0.1145
Entamoeba histolytica protein kinase, putative 0.0097 0.0388 0.1316
Trichomonas vaginalis CAMK family protein kinase 0.0262 0.1935 0.9269
Loa Loa (eye worm) TK protein kinase 0.019 0.1256 0.1256
Echinococcus multilocularis casein kinase I alpha 0.0105 0.0459 0.0636
Entamoeba histolytica protein kinase, putative 0.0134 0.0733 0.2487
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.0591 0.1162
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.13 0.2555
Schistosoma mansoni protein kinase 0.0083 0.0252 0.0496
Echinococcus granulosus tyrosine protein kinase Lyn 0.0261 0.1922 0.2184
Brugia malayi phosphoinositide-dependent protein kinase I 0.0078 0.0211 0.0211
Loa Loa (eye worm) TK/FER protein kinase 0.0104 0.0453 0.0453
Plasmodium falciparum calcium-dependent protein kinase 1 0.0097 0.0388 0.2623
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.012 0.0606 0.084
Schistosoma mansoni atypical protein kinase C 0.0276 0.2067 0.4061
Entamoeba histolytica PH domain containing protein kinase, putative 0.016 0.0979 0.3321
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0191 0.1266 0.1266
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0112 0.0528 0.06
Echinococcus granulosus c-Jun N-terminal kinases 0.0256 0.188 0.2136
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0583 0.2349
Brugia malayi Protein kinase domain containing protein 0.0436 0.3563 0.3563
Trypanosoma brucei Casein kinase II 0.0096 0.0381 0.0861
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0115 0.0552 0.1923
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.018 0.1163 0.1163
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0149 0.0872 0.0991
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0079 0.0221 0.0297
Echinococcus multilocularis casein kinase I gamma 0.0207 0.1414 0.196
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0109 0.0499 0.1494
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0283 0.0557
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0381 0.1611
Trichomonas vaginalis STE family protein kinase 0.0083 0.0252 0.0976
Loa Loa (eye worm) hypothetical protein 0.0121 0.061 0.061
Brugia malayi SRC-1 0.023 0.1631 0.1631
Echinococcus granulosus tyrosine protein kinase Blk 0.019 0.1256 0.1427
Giardia lamblia Kinase, CMGC CK2 0.0096 0.0381 0.0909
Echinococcus multilocularis mitogen activated protein kinase 3 0.0081 0.0232 0.0321
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0241 0.174 0.2412
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Brugia malayi Fes/CIP4 homology domain containing protein 0.0114 0.0545 0.0545
Echinococcus granulosus protein tyrosine kinase 0.0541 0.4551 0.5172
Echinococcus multilocularis mitogen activated protein kinase 0.0081 0.0232 0.0321
Entamoeba histolytica protein kinase domain containing protein 0.0124 0.0642 0.2178
Echinococcus multilocularis myosin iiia 0.0081 0.024 0.0333
Schistosoma mansoni serine/threonine-protein kinase 0.016 0.0979 0.1923
Loa Loa (eye worm) protein kinase domain-containing protein 0.0207 0.1414 0.1414
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Schistosoma mansoni neuroglian 0.006 0.0039 0.0076
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0079 0.0221 0.0297
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0231 0.164 0.2274
Trichomonas vaginalis AGC family protein kinase 0.0278 0.2083 1
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.014 0.0789 0.0897
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Trichomonas vaginalis AGC family protein kinase 0.0278 0.2083 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.1126 0.1126
Trichomonas vaginalis STE family protein kinase 0.0083 0.0252 0.0976
Brugia malayi protein unc-22 0.007 0.0133 0.0133
Echinococcus multilocularis c src tyrosine kinase 0.0144 0.0828 0.1148
Echinococcus granulosus cGMP dependent protein kinase 0.013 0.0696 0.0791
Brugia malayi Serine/threonine-protein kinase SULU 0.0215 0.1496 0.1496
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0159 0.0965 0.0965
Trypanosoma cruzi cdc2-related kinase 3 0.0115 0.0552 0.2171
Loa Loa (eye worm) hypothetical protein 0.0203 0.1378 0.1378
Echinococcus granulosus c src tyrosine kinase 0.0144 0.0828 0.0941
Echinococcus granulosus tyrosine kinase 0.019 0.1256 0.1427
Entamoeba histolytica protein kinase, putative 0.0118 0.0583 0.1978
Brugia malayi Protein kinase domain containing protein 0.0356 0.2816 0.2816
Trypanosoma cruzi aurora B kinase, putative 0.0086 0.0282 0.0642
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0109 0.0499 0.0692
Loa Loa (eye worm) hypothetical protein 0.0065 0.0082 0.0082
Echinococcus multilocularis neuroglian 0.006 0.0039 0.0054
Echinococcus granulosus dual specificity 0.0134 0.0736 0.0836
Brugia malayi Protein kinase domain containing protein 0.0195 0.13 0.13
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0097 0.0388 0.1009
Plasmodium vivax tyrosine kinase-like protein, putative 0.0078 0.0207 0.1678
Echinococcus multilocularis aurora kinase A 0.0086 0.0282 0.039
Brugia malayi Kinase associated domain 1 family protein 0.0099 0.0407 0.0407
Plasmodium vivax calcium-dependent protein kinase, putative 0.0097 0.0388 0.386
Loa Loa (eye worm) hypothetical protein 0.014 0.0788 0.0788
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0124 0.0642 0.2425
Schistosoma mansoni tyrosine kinase 0.0396 0.3188 0.6265
Brugia malayi probable protein kinase 0.0257 0.1886 0.1886
Toxoplasma gondii casein kinase I 0.0105 0.0459 0.1406
Loa Loa (eye worm) hypothetical protein 0.0449 0.369 0.369
Leishmania major casein kinase II, putative 0.0096 0.0381 0.0936
Echinococcus multilocularis dual specificity 0.0134 0.0736 0.102
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0518 0.2284
Trypanosoma brucei casein kinase I, isoform 2 0.0105 0.0459 0.128
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0149 0.087 0.3972
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.011 0.0509 0.0509
Echinococcus multilocularis expressed conserved protein 0.013 0.0696 0.0965
Loa Loa (eye worm) hypothetical protein 0.0109 0.0497 0.0497
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0149 0.0872 0.1209
Echinococcus multilocularis rac serine:threonine kinase 0.016 0.0979 0.1357
Onchocerca volvulus Tyrosine kinase homolog 0.0691 0.5952 1
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0134 0.0736 0.3006
Brugia malayi Protein kinase domain containing protein 0.0342 0.2686 0.2686
Echinococcus multilocularis roundabout 2 0.0151 0.0893 0.1237
Echinococcus granulosus casein kinase I alpha 0.0105 0.0459 0.0522
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0109 0.0499 0.0692
Entamoeba histolytica protein kinase, putative 0.0083 0.0252 0.0856
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0109 0.0497 0.0689
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0086 0.0282 0.0956
Echinococcus granulosus serine:threonine protein kinase N2 0.0275 0.2056 0.2337
Onchocerca volvulus Serine\/threonine kinase homolog 0.0159 0.0965 0.1622
Brugia malayi Protein kinase domain containing protein 0.0149 0.0872 0.0872
Plasmodium falciparum casein kinase 1 0.0105 0.0459 0.3656
Trichomonas vaginalis CAMK family protein kinase 0.0262 0.1935 0.9269
Entamoeba histolytica hypothetical protein 0.037 0.2947 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0781 0.0781
Echinococcus multilocularis casein kinase I delta 0.0105 0.0459 0.0636
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0086 0.0283 0.2601
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.1935 0.3802
Trypanosoma brucei SNF1-related protein kinases, putative 0.0086 0.0283 0.0336
Onchocerca volvulus 0.0619 0.5278 0.8867
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0209 0.1439 0.1995
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0081 0.024 0.0814
Entamoeba histolytica casein kinase, putative 0.0105 0.0459 0.1558
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0388 0.0538
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0109 0.0497 0.0977
Brugia malayi Furin-like cysteine rich region family protein 0.0599 0.5089 0.5089
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0115 0.0552 0.0552
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0736 0.336
Entamoeba histolytica casein kinase, putative 0.0096 0.0381 0.1293
Loa Loa (eye worm) hypothetical protein 0.0109 0.0499 0.0499
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0249 0.1812 0.1812
Trichomonas vaginalis CMGC family protein kinase 0.0081 0.0232 0.0873
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0149 0.087 0.3972
Echinococcus granulosus mitogen activated protein kinase 11 0.0154 0.092 0.1045
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0072 0.0151 0.0172
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.0474 0.0474
Echinococcus granulosus dual specificity protein kinase clk2 0.0149 0.087 0.0988
Schistosoma mansoni ste20-related kinase 0.0199 0.134 0.2633
Schistosoma mansoni tyrosine kinase 0.023 0.1631 0.3205
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.1439 0.2828
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0097 0.0388 0.386
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0149 0.087 0.3972
Echinococcus multilocularis tyrosine protein kinase Fyn 0.023 0.1631 0.2261
Schistosoma mansoni protein kinase 0.0231 0.164 0.3223
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0109 0.0499 0.0692
Loa Loa (eye worm) hypothetical protein 0.0099 0.0407 0.0407
Echinococcus multilocularis N chimaerin 0.0097 0.0382 0.0529
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0039 0.0039
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0086 0.0282 0.0956
Echinococcus multilocularis serine:threonine protein kinase N2 0.0275 0.2056 0.2851
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0211 0.1454 0.1454
Brugia malayi casein kinase I 0.0105 0.0459 0.0459
Echinococcus multilocularis tyrosine protein kinase Fyn 0.023 0.1631 0.2261
Echinococcus granulosus epidermal growth factor receptor 0.0396 0.3188 0.3623
Brugia malayi protein kinase C II. 0.0191 0.1266 0.1266
Giardia lamblia Kinase, CMGC CLK 0.0149 0.087 0.3769
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.014 0.0788 0.1093
Entamoeba histolytica PH domain containing protein kinase, putative 0.0118 0.0581 0.197
Schistosoma mansoni tyrosine kinase 0.0144 0.0828 0.1627
Loa Loa (eye worm) hypothetical protein 0.0106 0.0474 0.0474
Echinococcus granulosus nervana 2 0.012 0.0606 0.0689
Giardia lamblia Kinase, CMGC GSK 0.0124 0.0642 0.2435
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0079 0.0221 0.0078
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0068 0.0114 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0696 0.1368
Echinococcus granulosus tyrosine protein kinase shark 0.0312 0.2402 0.273
Schistosoma mansoni hypothetical protein 0.0099 0.0407 0.08
Plasmodium falciparum serine/threonine protein kinase KIN 0.0086 0.0283 0.111
Schistosoma mansoni tyrosine kinase 0.044 0.3605 0.7083
Loa Loa (eye worm) AUR protein kinase 0.0086 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0351 0.277 0.277
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0388 0.1643
Trichomonas vaginalis AGC family protein kinase 0.0158 0.0954 0.4434
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0081 0.024 0.0814
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0086 0.0283 0.0283
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0383 0.3066 0.3066
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0312 0.0612
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0124 0.0642 0.2681
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0736 0.336
Trypanosoma cruzi casein kinase, putative 0.0105 0.0459 0.1647
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0086 0.0282 0.032
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.006 0.0039 0.0039
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0124 0.0642 0.0642
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0228 0.1613 0.2236
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0081 0.0232 0.0138
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0097 0.0388 0.1009
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0456 0.3748 0.4259
Entamoeba histolytica protein kinase, putative 0.0269 0.2002 0.6791
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0081 0.024 0.0406
Schistosoma mansoni tyrosine kinase 0.044 0.3605 0.7083
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0134 0.0736 0.2766
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.008 0.0226 0.0226
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0736 0.336
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.006 0.0039 0.0044
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0083 0.0252 0.0287
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0105 0.0459 0.0459
Leishmania major protein kinase, putative 0.0081 0.024 0.0112
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0196 0.1317 0.1317
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0228 0.1613 0.1833
Loa Loa (eye worm) CDC7 protein kinase 0.0086 0.0287 0.0287
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Loa Loa (eye worm) hypothetical protein 0.0091 0.0334 0.0334
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0262 0.1935 1
Echinococcus granulosus aurora kinase A 0.0086 0.0282 0.032
Echinococcus granulosus serine:threonine protein kinase 3 0.0249 0.1812 0.2059
Brugia malayi Variant SH3 domain containing protein 0.0066 0.0093 0.0093
Entamoeba histolytica protein kinase, putative 0.0086 0.0282 0.0956
Plasmodium vivax serine/threonine protein kinase, putative 0.008 0.0226 0.1908
Echinococcus multilocularis titin 0.007 0.0133 0.0184
Echinococcus granulosus dual specificity 0.0134 0.0736 0.0836
Trichomonas vaginalis STE family protein kinase 0.0083 0.0252 0.0976
Plasmodium falciparum calcium-dependent protein kinase 5 0.0097 0.0388 0.2623
Echinococcus granulosus tyrosine protein kinase Fyn 0.023 0.1631 0.1854
Echinococcus multilocularis rho associated protein kinase 0.0382 0.3057 0.4238
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0124 0.0642 0.0729
Loa Loa (eye worm) TK/FER protein kinase 0.0104 0.0453 0.0453
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0322 0.2493 0.2493
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0152 0.0897 0.1244
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Echinococcus granulosus casein kinase I alpha 0.0105 0.0459 0.0522
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0152 0.0897 1
Entamoeba histolytica protein kinase, putative 0.0118 0.0583 0.1978
Trichomonas vaginalis CMGC family protein kinase 0.0081 0.0232 0.0873
Trypanosoma cruzi casein kinase, putative 0.0105 0.0459 0.1647
Loa Loa (eye worm) AGC/PKG protein kinase 0.013 0.0696 0.0696
Loa Loa (eye worm) hypothetical protein 0.0091 0.0331 0.0331
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0081 0.024 0.0406
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0324 0.2518 0.2518
Echinococcus multilocularis Immunoglobulin 0.0091 0.0331 0.0459
Brugia malayi protein-tyrosine kinase 0.019 0.1256 0.1256
Brugia malayi STE20-like kinase MST 0.0249 0.1812 0.1812
Echinococcus granulosus cGMP dependent protein kinase 1 0.013 0.0696 0.0791
Echinococcus multilocularis Immunoglobulin 0.0091 0.0331 0.0459
Giardia lamblia Kinase, CMGC CDK 0.0115 0.0552 0.1907
Loa Loa (eye worm) hypothetical protein 0.0234 0.1666 0.1666
Schistosoma mansoni protein kinase 0.0187 0.1228 0.2412
Echinococcus granulosus serine:threonine protein kinase 0.011 0.0509 0.0578
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0436 0.3563 0.3563
Brugia malayi protein kinase C3,putative 0.0153 0.0907 0.0907
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0381 0.1611
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0122 0.0618 0.2315
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0091 0.0331 0.065
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0086 0.0282 0.039
Loa Loa (eye worm) hypothetical protein 0.0583 0.4946 0.4946
Brugia malayi p70 ribosomal S6 kinase beta 0.0269 0.2002 0.2002
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0215 0.1496 0.1496
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0211 0.0414
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0481 0.3981 0.4524
Brugia malayi serine/threonine-protein kinase PAK 7 0.0225 0.1586 0.1586
Loa Loa (eye worm) TK/FER protein kinase 0.0104 0.0453 0.0453
Echinococcus granulosus serine:threonine protein kinase N2 0.0126 0.0661 0.0751
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0039 0.0039
Giardia lamblia Kinase, NEK 0.0132 0.071 0.2834
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.019 0.1256 0.1427
Giardia lamblia Kinase, PLK 0.0262 0.1935 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0097 0.0388 0.0897
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Onchocerca volvulus 0.0104 0.0453 0.0761
Echinococcus granulosus serine threonine protein kinase nrc 0.0152 0.0897 0.1019
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0282 0.112
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0109 0.0499 0.1494
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0779 0.6782 0.6782
Echinococcus multilocularis cyclin dependent kinase 5 0.0115 0.0552 0.0765
Echinococcus multilocularis casein kinase I alpha 0.0105 0.0459 0.0636
Schistosoma mansoni protein kinase 0.0422 0.3429 0.6738
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.018 0.1163 0.1322
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.2056 0.4041
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.023 0.1631 0.1854
Schistosoma mansoni tyrosine kinase 0.0541 0.4551 0.8943
Entamoeba histolytica protein kinase 2, putative 0.0152 0.0897 0.3044
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0124 0.0642 0.2457
Echinococcus granulosus roundabout 2 0.006 0.0039 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0736 0.336
Echinococcus granulosus tyrosine protein kinase Src42A 0.0143 0.0821 0.0933
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0481 0.3981 0.5519
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0097 0.0388 0.1009
Echinococcus granulosus roundabout 2 0.006 0.0039 0.0044
Brugia malayi Temporarily assigned gene name protein 59 0.0109 0.0497 0.0497
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0396 0.3188 0.3623
Brugia malayi Doublecortin family protein 0.0146 0.0844 0.0844
Entamoeba histolytica protein kinase, putative 0.0134 0.0736 0.2497
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0154 0.092 0.4079
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0736 0.1446
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.188 0.3694
Loa Loa (eye worm) TK/FER protein kinase 0.0104 0.0453 0.0453
Echinococcus multilocularis tyrosine protein kinase Blk 0.019 0.1256 0.1741
Echinococcus multilocularis serine:threonine protein kinase N2 0.0149 0.0872 0.1209
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Echinococcus multilocularis cGMP dependent protein kinase 1 0.013 0.0696 0.0965
Plasmodium falciparum serine/threonine protein kinase 0.008 0.0226 0.0277
Loa Loa (eye worm) hypothetical protein 0.0087 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0136 0.075 0.075
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0109 0.0497 0.0977
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0097 0.0382 0.075
Brugia malayi hypothetical protein 0.0104 0.0453 0.0453
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0226 0.0444
Brugia malayi Stress-activated protein kinase jnk-1 0.0256 0.188 0.188
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0324 0.2518 0.2518
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0097 0.0388 0.0388
Schistosoma mansoni ephrin receptor 0.0111 0.0514 0.1011
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0134 0.0736 0.0736
Loa Loa (eye worm) hypothetical protein 0.0226 0.1595 0.1595
Trichomonas vaginalis CMGC family protein kinase 0.0081 0.0232 0.0873
Trypanosoma cruzi rac serine-threonine kinase, putative 0.016 0.0979 0.4588
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.006 0.0039 0.0076
Schistosoma mansoni nck2/grb4 0.0096 0.0375 0.0737
Echinococcus granulosus raf serine:threonine protein kinase 0.0089 0.0312 0.0354
Loa Loa (eye worm) AGC/PKN protein kinase 0.0275 0.2056 0.2056
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0096 0.0375 0.0737
Trichomonas vaginalis CK1 family protein kinase 0.0105 0.0459 0.1995
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0078 0.0211 0.0292
Loa Loa (eye worm) TK/ROR protein kinase 0.0072 0.0151 0.0151
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.012 0.0606 0.0689
Echinococcus multilocularis tyrosine protein kinase Src42A 0.023 0.1631 0.2261
Brugia malayi Egg laying defective protein 4 0.013 0.0696 0.0696
Loa Loa (eye worm) CAMK protein kinase 0.007 0.0133 0.0133
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0583 0.2349
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0698 0.1372
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0111 0.0518 0.0718
Loa Loa (eye worm) hypothetical protein 0.0135 0.0744 0.0744
Schistosoma mansoni tyrosine kinase 0.023 0.1631 0.3205
Brugia malayi Sex muscle abnormal protein 5 0.0096 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0583 0.4946 0.4946
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.087 0.402
Plasmodium vivax unspecified product 0.0096 0.0381 0.378
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0283 0.0557
Schistosoma mansoni serine/threonine protein kinase 0.0342 0.2686 0.5279
Brugia malayi Hr1 repeat family protein 0.0275 0.2056 0.2056
Schistosoma mansoni growth factor receptor-bound protein 0.0096 0.0375 0.0737
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.007 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0079 0.0221 0.0221
Echinococcus granulosus tyrosine kinase 0.0104 0.0453 0.0514
Loa Loa (eye worm) hypothetical protein 0.0351 0.277 0.277
Echinococcus multilocularis tyrosine protein kinase HCK 0.0134 0.0733 0.1016
Giardia lamblia Kinase, NEK 0.0132 0.071 0.2834
Echinococcus granulosus Protein kinase C brain isozyme 0.0229 0.1628 0.185
Onchocerca volvulus 0.0139 0.0781 0.1312
Brugia malayi P38 map kinase family protein 2 0.0154 0.092 0.092
Trichomonas vaginalis AGC family protein kinase 0.0278 0.2083 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0087 0.0291 0.0987
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0149 0.087 0.3485
Trichomonas vaginalis CK1 family protein kinase 0.0105 0.0459 0.1995
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0404 0.3264 0.3709
Trichomonas vaginalis CAMK family protein kinase 0.0262 0.1935 0.9269
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0154 0.092 0.4255
Giardia lamblia Kinase, CAMK CAMKL 0.0086 0.0283 0.0337
Brugia malayi Protein kinase c protein 2 0.0112 0.0523 0.0523
Onchocerca volvulus 0.018 0.1163 0.1954
Onchocerca volvulus 0.0124 0.0642 0.1078
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.1628 0.3199
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0115 0.0552 0.0627
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0081 0.0232 0.0359
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.023 0.1631 0.2261
Trypanosoma cruzi casein kinase, putative 0.0105 0.0459 0.1647
Entamoeba histolytica protein kinase, putative 0.008 0.0226 0.0766
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0081 0.0232 0.0058
Entamoeba histolytica hypothetical protein 0.0118 0.0583 0.1978
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0086 0.0282 0.0956
Echinococcus granulosus neuroglian 0.006 0.0039 0.0044
Giardia lamblia Kinase, AGC PKA 0.0152 0.0897 0.3928
Echinococcus granulosus cyclin dependent kinase 1 0.0115 0.0552 0.0627
Echinococcus granulosus protein kinase c epsilon type 0.0191 0.1266 0.1438
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0552 0.1084
Toxoplasma gondii CMGC kinase, CK2 family 0.0096 0.0381 0.0972
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Loa Loa (eye worm) hypothetical protein 0.0136 0.075 0.075
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0072 0.0151 0.021
Entamoeba histolytica casein kinase 1, putative 0.0105 0.0459 0.1558
Brugia malayi Immunoglobulin I-set domain containing protein 0.0779 0.6782 0.6782
Schistosoma mansoni adapter molecule crk 0.0096 0.0375 0.0737
Echinococcus granulosus protein kinase 0.0148 0.0865 0.0983
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0381 0.1293
Plasmodium vivax protein kinase Crk2 0.0115 0.0552 0.5837
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0078 0.0208 0.0236
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0149 0.087 0.3695
Brugia malayi casein kinase 1, delta 0.0105 0.0459 0.0459
Giardia lamblia Kinase, CMGC DYRK 0.0134 0.0736 0.2985
Loa Loa (eye worm) TK/ALK protein kinase 0.0279 0.2089 0.2089
Giardia lamblia Kinase, CMGC GSK 0.0124 0.0642 0.2435
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.006 0.0039 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0499 0.0981
Echinococcus multilocularis dual specificity protein kinase clk2 0.0149 0.087 0.1206
Brugia malayi serine/threonine-protein kinase 6 0.0086 0.0282 0.0282
Schistosoma mansoni protein kinase 0.0062 0.0054 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0872 0.1714
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0118 0.0583 0.2114
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.164 0.3223
Brugia malayi Immunoglobulin I-set domain containing protein 0.007 0.0133 0.0133
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0211 0.0772
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0097 0.0388 0.0388
Echinococcus multilocularis dual specificity 0.0118 0.0583 0.0808
Brugia malayi map kinase activated protein kinase protein 2 0.0383 0.3066 0.3066
Onchocerca volvulus 0.0104 0.0453 0.0761
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0109 0.0499 0.1873
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0083 0.0252 0.035
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.006 0.0039 0.0054
Entamoeba histolytica protein kinase, putative 0.0078 0.0211 0.0716
Brugia malayi putative serine/threonine kinase SADA gamma 0.0086 0.0283 0.0283
Brugia malayi MAP kinase sur-1 0.0081 0.0232 0.0232
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0356 0.2816 0.32
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0642 0.2896
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0229 0.1628 0.2257
Echinococcus granulosus dual specificity 0.0134 0.0736 0.0836
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0422 0.3429 0.3897
Loa Loa (eye worm) AGC/AKT protein kinase 0.0278 0.2083 0.2083
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0388 0.0441
Loa Loa (eye worm) hypothetical protein 0.0118 0.0579 0.0579
Trichomonas vaginalis STE family protein kinase 0.0083 0.0252 0.0976
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.023 0.1631 0.1854
Echinococcus granulosus cyclin dependent kinase 0.0115 0.0552 0.0627
Echinococcus granulosus serine/threonine protein kinase 0.016 0.0979 0.1112
Schistosoma mansoni cell adhesion molecule 0.006 0.0039 0.0076
Entamoeba histolytica protein kinase, putative 0.0124 0.0642 0.2178
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Echinococcus granulosus tyrosine protein kinase Src42A 0.023 0.1631 0.1854
Brugia malayi Protein kinase domain containing protein 0.044 0.3605 0.3605
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0078 0.0208 0.0288
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0154 0.092 0.092
Echinococcus granulosus neuroglian 0.0115 0.0553 0.0628
Onchocerca volvulus 0.0062 0.0062 0.0103
Entamoeba histolytica protein kinase domain containing protein 0.0079 0.0221 0.0749
Onchocerca volvulus 0.0105 0.0459 0.0771
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0194 0.13 0.1802
Echinococcus multilocularis serine:threonine protein kinase 38 0.0149 0.0872 0.1209
Entamoeba histolytica protein kinase domain containing protein 0.0196 0.1317 0.4469
Brugia malayi Protein kinase domain containing protein 0.0279 0.209 0.209
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0342 0.2686 0.2686
Echinococcus granulosus casein kinase I gamma 0.0207 0.1414 0.1607
Trichomonas vaginalis AGC family protein kinase 0.0132 0.071 0.3232
Echinococcus granulosus serine:threonine kinase SAD 1 0.0086 0.0283 0.0322
Leishmania major protein kinase A catalytic subunit isoform 1 0.0109 0.0499 0.1624
Echinococcus granulosus protein kinase c iota type 0.027 0.2011 0.2285
Brugia malayi Protein kinase domain containing protein 0.0159 0.0965 0.0965
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0133 0.0261
Schistosoma mansoni protein kinase C mu 0.0211 0.1454 0.2857
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0381 0.1611
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0148 0.0865 0.0865
Echinococcus multilocularis tyrosine protein kinase Abl 0.0221 0.1552 0.2152
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.018 0.1163 0.1163
Schistosoma mansoni tyrosine kinase 0.0348 0.2736 0.5375
Onchocerca volvulus 0.0104 0.0453 0.0761
Echinococcus multilocularis calcium dependent protein kinase 0.0066 0.0097 0.0134
Echinococcus granulosus activin receptor type 0.0079 0.0221 0.0251
Loa Loa (eye worm) hypothetical protein 0.0062 0.0062 0.0062
Entamoeba histolytica protein kinase, putative 0.0098 0.0399 0.1355
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0211 0.0772
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0388 0.0441
Entamoeba histolytica protein kinase, putative 0.0068 0.0114 0.0386
Echinococcus multilocularis cyclin dependent kinase 1 0.0115 0.0552 0.0765
Schistosoma mansoni protein kinase 0.0422 0.3429 0.6738
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0109 0.0499 0.0567
Echinococcus multilocularis epidermal growth factor receptor 0.0396 0.3188 0.442
Echinococcus granulosus titin 0.007 0.0133 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.1613 0.3169
Echinococcus granulosus tyrosine protein kinase ABL1 0.0306 0.2347 0.2667
Brugia malayi Variant SH3 domain containing protein 0.0096 0.0375 0.0375
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0132 0.071 0.7746
Trypanosoma brucei protein kinase, putative 0.0081 0.0232 0.0058
Echinococcus multilocularis protein kinase shaggy 0.0124 0.0642 0.089
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.008 0.0226 0.003
Onchocerca volvulus Serine\/threonine kinase homolog 0.0262 0.1935 0.3251
Echinococcus multilocularis tyrosine protein kinase Fyn 0.023 0.1631 0.2261
Brugia malayi Protein kinase domain containing protein 0.0059 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0109 0.0497 0.0497
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0342 0.2686 0.2686
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0696 0.1368
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0383 0.3066 0.3484
Echinococcus multilocularis neuroglian 0.0115 0.0553 0.0766
Entamoeba histolytica cell division protein kinase 2, putative 0.0115 0.0552 0.1872
Onchocerca volvulus 0.0135 0.0744 0.125
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0081 0.0232 0.0063
Trichomonas vaginalis STE family protein kinase 0.0081 0.024 0.0915
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0152 0.0897 1
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0226 0.1595 0.1812
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Entamoeba histolytica protein kinase domain containing protein 0.0086 0.0282 0.0956
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0124 0.0642 0.089
Brugia malayi serine/threonine kinase 12 0.0086 0.0282 0.0282
Onchocerca volvulus 0.0086 0.0287 0.0481
Brugia malayi Protein kinase domain containing protein 0.0104 0.0453 0.0453
Echinococcus granulosus tyrosine protein kinase Fyn 0.023 0.1631 0.1854
Brugia malayi Protein kinase domain containing protein 0.0086 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0084 0.0261 0.0261
Schistosoma mansoni hypothetical protein 0.0109 0.0497 0.0977
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0342 0.2686 0.4513
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0109 0.0499 0.5201
Loa Loa (eye worm) TK protein kinase 0.0344 0.27 0.27
Trypanosoma cruzi casein kinase, putative 0.0105 0.0459 0.1647
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Onchocerca volvulus 0.0109 0.0497 0.0836
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0134 0.0736 0.3214
Leishmania major protein kinase, putative 0.0086 0.0282 0.0356
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0283 0.0557
Trypanosoma brucei protein kinase, putative 0.0124 0.0642 0.2261
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0118 0.0581 0.2598
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0232 0.0455
Trypanosoma cruzi polo-like protein kinase, putative 0.0262 0.1935 1
Brugia malayi Variant SH3 domain containing protein 0.0096 0.0375 0.0375
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0262 0.1935 0.2682
Trypanosoma cruzi Protein kinase B 0.016 0.0979 0.4588
Echinococcus multilocularis roundabout 2 0.006 0.0039 0.0054
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0109 0.0499 0.1494
Plasmodium falciparum NIMA related kinase 1 0.0132 0.071 0.7291
Loa Loa (eye worm) casein kinase 0.0176 0.1123 0.1123
Schistosoma mansoni vesicular amine transporter 0.0091 0.0331 0.065
Echinococcus multilocularis Glutaredoxin protein 5 0.012 0.0606 0.084
Loa Loa (eye worm) hypothetical protein 0.0135 0.0744 0.0744
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0241 0.174 0.1977
Trichomonas vaginalis CMGC family protein kinase 0.0081 0.0232 0.0873
Loa Loa (eye worm) AUR protein kinase 0.0086 0.0282 0.0282
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0091 0.033 0.033
Trypanosoma cruzi cdc2-related kinase 3 0.0115 0.0552 0.2171
Schistosoma mansoni tyrosine kinase 0.025 0.1824 0.3583
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0282 0.112
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0583 0.4946 0.4946
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0115 0.0552 0.1931
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0381 0.1611
Loa Loa (eye worm) hypothetical protein 0.0139 0.0781 0.0781
Onchocerca volvulus 0.0382 0.3057 0.5135
Trypanosoma brucei polo-like protein kinase 0.0262 0.1935 0.9203
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0083 0.0252 0.035
Brugia malayi hypothetical protein 0.0215 0.1496 0.1496
Echinococcus multilocularis insulin receptor 0.044 0.3605 0.4997
Onchocerca volvulus 0.007 0.0133 0.0223
Entamoeba histolytica PH domain containing protein kinase, putative 0.016 0.0979 0.3321
Echinococcus granulosus cGMP dependent protein kinase 1 0.013 0.0696 0.0791
Schistosoma mansoni tyrosine kinase 0.0599 0.5089 1
Trypanosoma cruzi cdc2-related kinase 1 0.0115 0.0552 0.2171
Loa Loa (eye worm) TK protein kinase 0.0134 0.0733 0.0733
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0342 0.2686 0.3724
Loa Loa (eye worm) hypothetical protein 0.0284 0.214 0.214
Schistosoma mansoni protein kinase 0.0231 0.164 0.3223
Echinococcus granulosus rho-associated protein kinase 1 0.0382 0.3057 0.3473
Loa Loa (eye worm) hypothetical protein 0.0189 0.1245 0.1245
Echinococcus granulosus calcium activated potassium channel 0.013 0.0698 0.0793
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.04 0.3223 0.4468
Echinococcus granulosus dual specificity 0.0118 0.0583 0.0663
Brugia malayi Tyrosine-protein kinase abl-1 0.0221 0.1552 0.1552
Brugia malayi Protein kinase domain containing protein 0.0278 0.2083 0.2083
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0552 0.1084
Schistosoma mansoni tyrosine kinase 0.0396 0.3188 0.6265
Schistosoma mansoni protein kinase 0.0096 0.0381 0.0749
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0086 0.0283 0.0365
Echinococcus multilocularis epidermal growth factor receptor 0.0599 0.5089 0.7055
Echinococcus multilocularis tyrosine protein kinase shark 0.0312 0.2402 0.333
Echinococcus granulosus casein kinase I delta 0.0105 0.0459 0.0522
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0342 0.2686 0.2686
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.1496 0.294
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0356 0.2816 0.3904
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.1439 0.2828
Schistosoma mansoni vav2 0.0105 0.0464 0.0911
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0149 0.087 0.3485
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0154 0.092 0.3754
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0381 0.1611
Loa Loa (eye worm) TK/FER protein kinase 0.0104 0.0453 0.0453
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.1317 0.2588
Brugia malayi intracellular kinase 0.0124 0.0642 0.0642
Plasmodium falciparum calcium-dependent protein kinase 3 0.0097 0.0388 0.2623
Onchocerca volvulus 0.0104 0.0453 0.0761
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0134 0.0736 0.2949
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0262 0.1935 0.2199
Plasmodium falciparum protein kinase 5 0.0115 0.0552 0.4998
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0388 0.0762
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0109 0.0499 0.0692
Echinococcus granulosus casein kinase ii subunit alpha 0.0096 0.0381 0.0433
Schistosoma mansoni tyrosine kinase 0.0348 0.2736 0.5375
Giardia lamblia Kinase, CDC7 0.0086 0.0287 0.0356
Trichomonas vaginalis CAMK family protein kinase 0.0262 0.1935 0.9269
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0097 0.0388 0.0388
Echinococcus granulosus mitogen activated protein kinase 14 0.0154 0.092 0.1045
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0105 0.0459 0.0459
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0583 0.4946 0.4946
Schistosoma mansoni protein kinase 0.0079 0.0221 0.0434
Plasmodium falciparum protein kinase, putative 0.0079 0.0221 0.0203
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0225 0.1586 0.1586
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0209 0.1439 0.1995
Plasmodium falciparum cGMP-dependent protein kinase 0.013 0.0696 0.7086
Loa Loa (eye worm) SRC-1 0.023 0.1631 0.1631
Loa Loa (eye worm) hypothetical protein 0.0096 0.0375 0.0375
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0342 0.2686 0.3052
Schistosoma mansoni tyrosine kinase 0.0348 0.2736 0.5375
Entamoeba histolytica p21-activated kinase 0.0091 0.0334 0.1133
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0097 0.0382 0.0434
Echinococcus multilocularis PAK box P21 Rho binding 0.0062 0.0054 0.0075
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0241 0.174 0.2412
Brugia malayi Protein kinase domain containing protein 0.011 0.0509 0.0509
Echinococcus granulosus casein kinase i 0.0105 0.0459 0.0522
Echinococcus multilocularis cyclin dependent kinase 1 0.0115 0.0552 0.0765
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0105 0.0459 0.0459
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0109 0.0497 0.1485
Loa Loa (eye worm) hypothetical protein 0.011 0.0509 0.0509
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0215 0.1496 0.17
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0211 0.0772
Echinococcus granulosus tyrosine protein kinase 0.0282 0.2119 0.2408
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0149 0.0872 0.0991
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0109 0.0499 0.1873
Leishmania major protein kinase, putative 0.0149 0.087 0.3787
Schistosoma mansoni serine/threonine protein kinase 0.0383 0.3066 0.6025
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0066 0.0093 0.0093
Echinococcus granulosus mitogen activated protein kinase 3 0.0081 0.0232 0.0263
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.008 0.0226 0.0326
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0642 0.2896
Entamoeba histolytica protein kinase, putative 0.0278 0.2083 0.7068
Schistosoma mansoni nephrin 0.006 0.0039 0.0076
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.0647 0.0647
Loa Loa (eye worm) hypothetical protein 0.0126 0.0654 0.0654
Brugia malayi Protein kinase domain containing protein 0.0207 0.1414 0.1414
Plasmodium falciparum casein kinase 2, alpha subunit 0.0096 0.0381 0.2526
Loa Loa (eye worm) AGC/PKA protein kinase 0.0109 0.0499 0.0499
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0194 0.13 0.1477
Brugia malayi Protein kinase domain containing protein 0.0115 0.0552 0.0552
Echinococcus multilocularis protein tyrosine kinase 0.0541 0.4551 0.631
Brugia malayi Protein kinase domain containing protein 0.0078 0.0211 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0382 0.3057 0.6006
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0096 0.0381 0.0381
Schistosoma mansoni protein kinase 0.0257 0.1886 0.3705
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0105 0.0459 0.1647
Brugia malayi cell division control protein 2 homolog 0.0115 0.0552 0.0552
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0231 0.164 0.2274
Entamoeba histolytica protein kinase, putative 0.007 0.0136 0.0461
Loa Loa (eye worm) hypothetical protein 0.0109 0.0497 0.0497
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0388 0.0538
Echinococcus granulosus cyclin dependent kinase 5 0.0115 0.0552 0.0627
Echinococcus multilocularis mitogen activated protein kinase 14 0.0154 0.092 0.1275
Entamoeba histolytica serine/threonine protein kinase, putative 0.0262 0.1935 0.6565
Schistosoma mansoni kinase 0.028 0.2103 0.4133
Echinococcus multilocularis 0.0169 0.1063 0.1473
Echinococcus multilocularis contactin neuroglian septate junction protein 0.006 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0086 0.0283 0.0283
Echinococcus granulosus serine:threonine protein kinase 0.011 0.0509 0.0578
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0282 0.112
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0283 0.1129
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0383 0.3066 0.4251
Echinococcus granulosus epidermal growth factor receptor 0.0599 0.5089 0.5783
Echinococcus multilocularis cyclin dependent kinase 0.0115 0.0552 0.0765
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.0583 0.1978
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0143 0.0821 0.1139
Giardia lamblia Kinase, CMGC CDK 0.0115 0.0552 0.1907
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0196 0.1317 0.1317

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9 nM Inhibition of ROCK2 ChEMBL. 22018789
IC50 (binding) = 110 nM Inhibition of ROCK1 ChEMBL. 22018789

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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