Detailed information for compound 1638489

Basic information

Technical information
  • TDR Targets ID: 1638489
  • Name: sodium 5-[3-pyridin-2-yl-6-(5-sulfofuran-2-yl )-1,2,4-triazin-5-yl]furan-2-sulfonate
  • MW: 472.384 | Formula: C16H9N4NaO8S2
  • H donors: 2 H acceptors: 10 LogP: -0.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OS(=O)(=O)c1ccc(o1)c1nc(nnc1c1ccc(o1)S(=O)(=O)[O-])c1ccccn1.[Na+]
  • InChi: 1S/C16H10N4O8S2.Na/c21-29(22,23)12-6-4-10(27-12)14-15(11-5-7-13(28-11)30(24,25)26)19-20-16(18-14)9-3-1-2-8-17-9;/h1-8H,(H,21,22,23)(H,24,25,26);/q;+1/p-1
  • InChiKey: CGAHGMQKUPCZKN-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • sodium 5-[3-(2-pyridyl)-6-(5-sulfo-2-furyl)-1,2,4-triazin-5-yl]furan-2-sulfonate
  • sodium 5-[3-(2-pyridyl)-6-(5-sulfo-2-furyl)-1,2,4-triazin-5-yl]-2-furansulfonate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0114 0.0236 0.0236
Schistosoma mansoni lamin 0.0026 0.0029 0.0026
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0131 0.0128
Echinococcus granulosus ubiquitin specific protease 41 0.0047 0.0077 0.0075
Echinococcus granulosus sex peptide receptor 0.0017 0.0006 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.3332 0.333
Schistosoma mansoni cpg binding protein 0.003 0.0037 0.0035
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1764 0.4134 0.4132
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0006 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.0439 0.0437
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0106 0.0104
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0614 0.0788
Brugia malayi MH2 domain containing protein 0.0034 0.0047 0.0047
Plasmodium falciparum stearoyl-CoA desaturase 0.0122 0.0255 0.4015
Mycobacterium tuberculosis Conserved protein 0.0078 0.0152 0.1268
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0238 0.0235
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0274 0.0614 0.0612
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0047 0.0077 0.0063
Echinococcus granulosus Fatty acid desaturase type 1 0.0032 0.0043 0.0041
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0019 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Leishmania major peptidylprolyl isomerase-like protein 0.0059 0.0106 0.0086
Mycobacterium ulcerans hypothetical protein 0.0078 0.0152 0.3422
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.034 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.0614 0.0612
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0014 0.0012
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0031
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Entamoeba histolytica protein kinase, putative 0.0032 0.0043 0.0029
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0006 0.0004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.02 0.0439 0.0439
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0106 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.0018 0.0009 0.0009
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0076 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 1 1
Schistosoma mansoni ferritin 0.0017 0.0007 0.0005
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0274 0.0614 0.0612
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0188 0.2891
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0152 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0122 0.0255 0.4015
Trichomonas vaginalis esterase, putative 0.0078 0.0152 0.015
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0069 0.0055
Echinococcus granulosus expressed protein 0.0017 0.0007 0.0005
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0006 0.0004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0238 0.0235
Onchocerca volvulus 0.0078 0.0152 0.2448
Trichomonas vaginalis ferritin, putative 0.0017 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0047 0.0077 0.0075
Treponema pallidum NADH oxidase 0.0032 0.0043 0.3679
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0059 0.0449
Echinococcus granulosus geminin 0.053 0.1218 0.1216
Brugia malayi Thioredoxin reductase 0.0094 0.0188 0.0188
Schistosoma mansoni immunophilin 0.0051 0.0087 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Echinococcus multilocularis serotonin receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis serotonin receptor 0.0017 0.0006 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0006 0.0004
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0274 0.0614 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1424 0.3332 0.3329
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0031 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.2289 0.5376 0.5375
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi neuropeptide F receptor 0.0017 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0114 0.0236 0.0234
Echinococcus multilocularis Smad4 0.0034 0.0047 0.0044
Brugia malayi hypothetical protein 0.0178 0.0388 0.0388
Schistosoma mansoni biogenic amine receptor 0.0017 0.0006 0.0004
Brugia malayi hypothetical protein 0.0018 0.0009 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0152 0.015
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0006 0.0004
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0274 0.0614 0.0612
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0019 0.0016
Echinococcus granulosus allatostatin A receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0237 0.0527 0.4546
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0082 0.008
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0006 0.0004
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0006 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0274 0.0614 0.0614
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0047 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0895 0.2081 0.2081
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.0032 0.0043 0.0848
Trichomonas vaginalis PIKK family atypical protein kinase 0.2537 0.5962 0.5961
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0152 0.015
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0015 0.0013
Schistosoma mansoni hypothetical protein 0.053 0.1218 0.1216
Brugia malayi MH2 domain containing protein 0.0015 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0649 0.0647
Loa Loa (eye worm) phosphatidylinositol 3 0.0274 0.0614 0.0614
Schistosoma mansoni smad 0.0034 0.0047 0.0044
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0274 0.0614 0.0612
Brugia malayi intermediate filament protein 0.0026 0.0029 0.0029
Schistosoma mansoni opsin-like receptor 0.0017 0.0006 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.4246 1 1
Onchocerca volvulus 0.0274 0.0614 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0274 0.0614 0.0612
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0059 0.0106 0.0092
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0006 0.0004
Onchocerca volvulus 0.0017 0.0006 0.0059
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0006 0.0006
Schistosoma mansoni apoferritin-2 0.0017 0.0007 0.0005
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0274 0.0614 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.3377 0.7947 0.7947
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0803 0.1865 0.1861
Trichomonas vaginalis PIKK family atypical protein kinase 0.2293 0.5384 0.5383
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma cruzi Protein kinase B 0.0022 0.0019 0.0005
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0002 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.036 0.0818 0.0818
Entamoeba histolytica hypothetical protein 0.0115 0.0238 0.0223
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0032 0.0043 0.0041
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0274 0.0614 0.0611
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0076 0.0146 0.0146
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0047 0.0077 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.3625 0.8533 0.8533
Leishmania major phosphatidylinositol kinase related protein, putative 0.0274 0.0614 0.0595
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0415 0.0412
Onchocerca volvulus 0.0178 0.0388 0.6301
Loa Loa (eye worm) hypothetical protein 0.0865 0.2012 0.2012
Loa Loa (eye worm) hypothetical protein 0.0529 0.1217 0.1217
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0069 0.0055
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0043 0.0029
Echinococcus granulosus tumor protein p63 0.0333 0.0754 0.0752
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0009
Echinococcus multilocularis fk506 binding protein 0.0059 0.0106 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0415 0.0412
Onchocerca volvulus 0.0049 0.0082 0.1302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0043 0.0029
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0006 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0043 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0274 0.0614 0.0614
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0047 0.0077 0.0057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0043 0.585
Onchocerca volvulus 0.0017 0.0006 0.0059
Mycobacterium tuberculosis Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f 0.0032 0.0043 0.0314
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0014 0.0012
Schistosoma mansoni opsin-like receptor 0.0017 0.0006 0.0004
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0006 0.0004
Plasmodium falciparum glutathione reductase 0.0032 0.0043 0.0484
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.2289 0.5376 0.5375
Brugia malayi MH1 domain containing protein 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0154 0.0331 0.5378
Trichomonas vaginalis PIKK family atypical protein kinase 0.2293 0.5384 0.5383
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0043 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Onchocerca volvulus 0.0017 0.0006 0.0059
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1424 0.3332 0.333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0803 0.1865 0.1863
Trichomonas vaginalis PIKK family atypical protein kinase 0.3158 0.7429 0.7428
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0501 0.1151 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0123 0.0121
Loa Loa (eye worm) beta-lactamase 0.0078 0.0152 0.0152
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0059 0.0106 0.0106
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0621 0.1434 0.1432
Loa Loa (eye worm) hypothetical protein 0.0078 0.0152 0.0152
Onchocerca volvulus 0.0032 0.0043 0.0663
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0006 0.0006
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0059 0.0106 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0006 0.0004
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0274 0.0614 0.0601
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0047 0.0077 0.0063
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0006 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0188 0.0174
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.0274 0.0614 0.0614
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.002 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0006 0.0004
Schistosoma mansoni ferritin light chain 0.0017 0.0007 0.0005
Mycobacterium ulcerans transmembrane alkane 1-monooxygenase AlkB 0.0032 0.0043 0.0848
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.002 0.0312
Brugia malayi beta-lactamase family protein 0.0078 0.0152 0.0152
Echinococcus granulosus cpg binding protein 0.003 0.0037 0.0035
Giardia lamblia GTOR 0.4246 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0495 0.1137 0.1137
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0106 0.0092
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0043 0.0043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.036 0.0818 0.0818
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0274 0.0614 0.0612
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.005 0.0035
Trypanosoma brucei trypanothione reductase 0.0094 0.0188 0.0184
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.005 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.3158 0.7429 0.7428
Echinococcus multilocularis expressed protein 0.0017 0.0007 0.0005
Trypanosoma cruzi cytochrome b5-dependent oleate desaturase 0.0032 0.0043 0.0029
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0006 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.0439 0.0437
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0006 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.005 0.0047
Schistosoma mansoni ferritin light chain 0.0017 0.0007 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0274 0.0614 0.0614
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0031 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.2537 0.5962 0.5961
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0032 0.0043 0.0029
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.005 0.0047
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0152 0.1268
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0123 0.0121
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0327 0.074 0.0736
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0041
Mycobacterium leprae Probable lipase LipE 0.0078 0.0152 0.239
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0032 0.0043 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0274 0.0614 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0114 0.0236 0.0234
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0006 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0274 0.0614 0.0612
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0006 0.0004
Schistosoma mansoni smad1 5 8 and 0.0034 0.0047 0.0044
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0274 0.0614 0.0612
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.005 0.0047
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0006 0.0004
Onchocerca volvulus 0.0017 0.0006 0.0059
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0274 0.0614 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0006 0.0006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0123 0.0123
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0614 0.0595
Schistosoma mansoni inositol monophosphatase 0.0043 0.0069 0.0067
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable dehydrogenase 0.0213 0.0471 0.4055
Loa Loa (eye worm) fatty acid desaturase 0.0032 0.0043 0.0043
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0006 0.0004
Leishmania major hypothetical protein, conserved 0.0078 0.0152 0.0132
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0019 0.0017
Schistosoma mansoni cpg binding protein 0.003 0.0037 0.0035
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0043 0.0016
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0006 0.0004
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0006 0.0006
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0076 0.0146 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0043 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0131 0.0128
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0289 0.0649 0.0649
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0059 0.0106 0.0106
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4246 1 1
Schistosoma mansoni amine GPCR 0.0017 0.0006 0.0004
Echinococcus granulosus lamin 0.0026 0.0029 0.0026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0043 0.0029
Trypanosoma brucei fatty acid desaturase, putative 0.0154 0.0331 0.0328
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0274 0.0614 0.0612
Schistosoma mansoni Smad4 0.0034 0.0047 0.0044
Brugia malayi Protein kinase domain containing protein 0.0032 0.0043 0.0043
Schistosoma mansoni immunophilin 0.0059 0.0106 0.0104
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0047 0.0077 0.0073
Trypanosoma brucei unspecified product 0.0023 0.002 0.0017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0114 0.0236 0.0234
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0006 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0041
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0006 0.0004
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma cruzi fatty acid desaturase, putative 0.0154 0.0331 0.0317
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0333 0.0319
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0274 0.0614 0.0612
Echinococcus granulosus tar DNA binding protein 0.0066 0.0123 0.0121
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0246 0.0549 0.0549
Onchocerca volvulus 0.0017 0.0006 0.0059
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.034 0.0338
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma brucei sphingolipid delta 4 desaturase, putative 0.0032 0.0043 0.0039
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4246 1 1
Brugia malayi Delta5 fatty acid desaturase 0.0032 0.0043 0.0043
Plasmodium vivax hypothetical protein 0.0274 0.0614 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0274 0.0614 0.0601
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0069 0.0055
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0043 0.004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.002 0.002
Onchocerca volvulus 0.0017 0.0006 0.0059
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0274 0.0614 0.0612
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0006 0.0004
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0274 0.0614 0.0601
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0274 0.0614 0.0601
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0043 0.0023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0043 0.0043
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0274 0.0614 0.0601
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0059 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0114 0.0236 0.0234
Echinococcus multilocularis dna polymerase kappa 0.0023 0.002 0.0018
Schistosoma mansoni lamin 0.0026 0.0029 0.0026
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.0274 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0803 0.1865 0.1863
Brugia malayi RNA binding protein 0.0066 0.0123 0.0123
Plasmodium falciparum thioredoxin reductase 0.0094 0.0188 0.2891
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni histamine h1 receptor 0.0017 0.0006 0.0004
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0274 0.0614 0.0601
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0019 0.0017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0006 0.0004
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.074 0.0727
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0614 0.0601
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0006 0.0004
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0006 0.0006
Brugia malayi Fatty acid desaturase family protein 0.0032 0.0043 0.0043
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0043 0.0484
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0009
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0076 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0043 0.0029
Echinococcus granulosus smad 0.0034 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0274 0.0614 0.0614
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3381 0.7955 0.7951
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0006 0.0004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0274 0.0614 0.0611
Echinococcus multilocularis smad 0.0034 0.0047 0.0044
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0803 0.1865 0.1863
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.002 0.0018
Toxoplasma gondii ABC1 family protein 0.0078 0.0152 0.0163
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0006 0.0004
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.005 0.0047
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0043 0.0029
Plasmodium falciparum thioredoxin reductase 0.0032 0.0043 0.0484
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0006 0.0004
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0274 0.0614 0.0612
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0076 0.0072
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0032 0.0043 0.0023
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0006 0.0004
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0023 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0114 0.0236 0.0236
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1424 0.3332 0.3329
Onchocerca volvulus 0.0017 0.0006 0.0059
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.002 0.0116
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma brucei rac serine-threonine kinase, putative 0.0032 0.0043 0.0039
Echinococcus granulosus g protein coupled receptor 0.0017 0.0006 0.0004
Brugia malayi Fatty acid desaturase family protein 0.0032 0.0043 0.0043
Mycobacterium tuberculosis Conserved protein 0.0078 0.0152 0.1268
Brugia malayi MH1 domain containing protein 0.0019 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.1434 0.1432
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0614 0.0601
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0019 0.0017
Loa Loa (eye worm) inositol-1 0.0043 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) TK/ALK protein kinase 0.0018 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.2293 0.5384 0.5383
Trichomonas vaginalis PIKK family atypical protein kinase 0.3158 0.7429 0.7428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.04 0.0912 0.091
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0274 0.0614 0.0612
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.02 0.0439 0.0439
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0059 0.0106 0.1524
Loa Loa (eye worm) FAT-3 protein 0.0032 0.0043 0.0043
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0003 0.0003
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.005 0.0047
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0189 0.0187
Brugia malayi FAT domain containing protein 0.0621 0.1434 0.1434
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0006 0.0004
Brugia malayi larval opioid receptor 0.0017 0.0006 0.0006
Trypanosoma cruzi fatty acid desaturase, putative 0.0122 0.0255 0.0241
Schistosoma mansoni ferritin 0.0017 0.0007 0.0005
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0032 0.0043 0.0314
Echinococcus multilocularis somatostatin receptor 0.0017 0.0006 0.0004
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0106 0.0102
Schistosoma mansoni myosin xvIII 0.0017 0.0006 0.0004
Trypanosoma brucei cytochrome b5-dependent oleate desaturase 0.0032 0.0043 0.0039
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0029 0.0029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0131 0.2911
Mycobacterium ulcerans hypothetical protein 0.0032 0.0043 0.0848
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4246 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0614 0.0611
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0274 0.0614 0.0601
Onchocerca volvulus 0.0017 0.0006 0.0059
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0006 0.0004
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0274 0.0614 0.0612
Echinococcus granulosus dna polymerase kappa 0.0023 0.002 0.0018
Giardia lamblia DINP protein human, muc B family 0.0023 0.002 0.0006
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0274 0.0614 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0123 0.0121
Brugia malayi TAR-binding protein 0.0066 0.0123 0.0123
Loa Loa (eye worm) fatty acid desaturase 0.0032 0.0043 0.0043
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0006 0.0004
Brugia malayi AKH receptor 0.0017 0.0006 0.0006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0043 0.0041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0152 0.015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.034 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.1139 0.2659 0.2657
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.0038 0.0038
Leishmania major fatty acid desaturase, putative 0.0032 0.0043 0.0023
Brugia malayi ORL1-like opioid receptor 0.0017 0.0006 0.0006
Brugia malayi Dopamine receptor protein 1 0.0017 0.0006 0.0006
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3_2 0.0032 0.0043 0.0848
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.005 0.0047
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0087 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0614 0.0788
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.002 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0043 0.004
Schistosoma mansoni alpha-glucosidase 0.0136 0.0288 0.0286
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0043 0.0041
Entamoeba histolytica protein kinase, putative 0.0032 0.0043 0.0029
Mycobacterium tuberculosis Probable reductase 0.0213 0.0471 0.4055
Loa Loa (eye worm) hypothetical protein 0.0078 0.0152 0.0152
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0106 0.0092
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0006 0.0004
Onchocerca volvulus 0.0026 0.0029 0.0427
Loa Loa (eye worm) hypothetical protein 0.0621 0.1434 0.1434
Brugia malayi beta-lactamase family protein 0.0078 0.0152 0.0152
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0152 0.1268
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0274 0.0614 0.0612
Trypanosoma cruzi fatty acid desaturase, putative 0.0122 0.0255 0.0241
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0006 0.0004
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0047 0.0077 0.0075
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0274 0.0614 0.0612
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0032 0.0043 0.0023
Echinococcus granulosus somatostatin receptor 0.0017 0.0006 0.0004
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi hypothetical protein 0.0115 0.0238 0.0238
Echinococcus multilocularis serine protein kinase ATM 0.0803 0.1865 0.1863
Schistosoma mansoni hypothetical protein 0.0114 0.0236 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0041
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0274 0.0614 0.0611
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.074 0.0727
Loa Loa (eye worm) hypothetical protein 0.0246 0.0549 0.0549
Leishmania major fatty acid desaturase, putative 0.0032 0.0043 0.0023
Echinococcus granulosus neuropeptide receptor 0.0325 0.0734 0.0732
Brugia malayi Dopamine receptor 0.0017 0.0006 0.0006
Giardia lamblia Phosphatidylinositol 4-kinase 0.0274 0.0614 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.2848 0.6697 0.6696
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0106 0.0092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4246 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.002 0.002
Brugia malayi G-protein coupled receptor 0.0017 0.0006 0.0006
Brugia malayi acyl-CoA desaturase 0.0122 0.0255 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0895 0.2081 0.208
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0274 0.0614 0.0612
Echinococcus granulosus dnaJ subfamily B 0.04 0.0912 0.091
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0069 0.0067
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0803 0.1865 0.1853
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0006 0.0059
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0019 0.0016
Leishmania major hypothetical protein, conserved 0.0027 0.0031 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0043 0.0023
Echinococcus multilocularis nervana 2 0.002 0.0014 0.0012
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0895 0.2081 0.2771
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0069 0.0051
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0047 0.0077 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0115 0.0238 0.0235
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0274 0.0614 0.0601
Toxoplasma gondii target of rapamycin (TOR), putative 0.3158 0.7429 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.002 0.0006
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0614 0.0788
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.005 0.005
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1424 0.3332 0.3318
Schistosoma mansoni neuropeptide receptor 0.0325 0.0734 0.0732
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0043 0.585
Loa Loa (eye worm) phosphatidylinositol 3 0.1424 0.3332 0.3332
Echinococcus granulosus dna polymerase eta 0.0023 0.002 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0043 0.004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0076 0.0061
Trypanosoma brucei delta-6 fatty acid desaturase, putative 0.0032 0.0043 0.0039
Loa Loa (eye worm) glutathione reductase 0.0094 0.0188 0.0188
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.005 0.0025
Onchocerca volvulus 0.0017 0.0006 0.0059
Brugia malayi GnHR receptor homolog 0.0017 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0649 0.0647
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0152 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0031 0.0017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0006 0.0006
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0131 0.0128
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0196 0.0431 0.3707
Onchocerca volvulus 0.0091 0.0183 0.2945
Brugia malayi Serotonin receptor 0.0017 0.0006 0.0006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0069 0.1465
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0043 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.0431 1
Brugia malayi SEA domain containing protein 0.0016 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.0439 0.0437
Brugia malayi hypothetical protein 0.0027 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Brugia malayi Serotonin receptor 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0803 0.1865 0.1865
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0196 0.0431 0.0412
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0006 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.2293 0.5384 0.5383
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0006 0.0004
Toxoplasma gondii FATC domain-containing protein 0.0803 0.1865 0.2478
Toxoplasma gondii thioredoxin reductase 0.0094 0.0188 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0649 0.0647
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0614 0.0788
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0006 0.0004
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma cruzi sphingolipid delta 4 desaturase, putative 0.0032 0.0043 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.0431 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.002 0.0018
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0006 0.0059
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.002 0.0312
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0006 0.0004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0131 0.2911
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium ulcerans hypothetical protein 0.0032 0.0043 0.0848
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0087 0.0085
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0019 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0196 0.0431 0.0429
Brugia malayi Dopamine receptor protein 2 0.0017 0.0006 0.0006
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0032 0.0043 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0006 0.0004
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0614 0.0788
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.3332 0.333
Onchocerca volvulus 0.0017 0.0006 0.0059
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0196 0.0431 0.0429
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0069 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0019 0.0016
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0006 0.0006
Schistosoma mansoni inositol monophosphatase 0.0043 0.0069 0.0067
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0152 0.015
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0006 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0043 0.0029
Echinococcus multilocularis geminin 0.053 0.1218 0.1216
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 1 1
Echinococcus granulosus g protein coupled receptor 0.0017 0.0006 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0043 0.0029
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0274 0.0614 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0289 0.0649 0.0649
Onchocerca volvulus 0.0026 0.0029 0.0427
Leishmania major fk506-binding protein 1-like protein 0.0059 0.0106 0.0086
Schistosoma mansoni ferritin 0.0017 0.0007 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0093 0.0083
Echinococcus granulosus nervana 2 0.002 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus MAM 0.0018 0.0009 0.0006
Onchocerca volvulus 0.0018 0.0009 0.0101
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4246 1 1
Onchocerca volvulus Glucosylceramidase homolog 0.0189 0.0415 0.6736
Onchocerca volvulus 0.0078 0.0152 0.2448
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0152 0.0149
Echinococcus multilocularis GPCR, family 2 0.0114 0.0236 0.0234
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0019 0.0005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0043 0.0857
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0069 0.0065
Schistosoma mansoni DNA polymerase eta 0.0023 0.002 0.0018
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.002 0.0018
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0047 0.0044
Echinococcus granulosus ferritin 0.0017 0.0007 0.0005
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.0032 0.0043 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0162 0.016
Echinococcus multilocularis Fatty acid desaturase, type 1 0.0032 0.0043 0.0041
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0274 0.0614 0.0601
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0006 0.0004
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0006 0.0004
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0274 0.0614 0.0612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.0439 0.0437
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.0439 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.3158 0.7429 0.7428
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0123 0.0123
Mycobacterium ulcerans electron transfer protein FdxB 0.0032 0.0043 0.0848
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0069 0.0067
Schistosoma mansoni amine GPCR 0.0017 0.0006 0.0004
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0106 0.0104
Trichomonas vaginalis fk506-binding protein, putative 0.0059 0.0106 0.0104
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0019 0.0005
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0059 0.0106 0.0104
Schistosoma mansoni opsin-like receptor 0.0017 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0246 0.0549 0.0547
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0803 0.1865 0.1865
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.0014 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0018 0.0009 0.0006
Echinococcus granulosus intermediate filament protein 0.0026 0.0029 0.0026
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0106 0.0104
Loa Loa (eye worm) nuclear factor I 0.0019 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.2537 0.5962 0.5961
Brugia malayi Smad1 0.0034 0.0047 0.0047
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0033 0.0033
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0274 0.0614 0.0612
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0006 0.0004
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0333 0.0313
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0152 0.239
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4246 1 1
Leishmania major delta-12 fatty acid desaturase 0.0032 0.0043 0.0023
Schistosoma mansoni fkbp-rapamycin associated protein 0.0803 0.1865 0.1863
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0043 0.0023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1424 0.3332 0.3322
Entamoeba histolytica protein kinase rad3, putative 0.0803 0.1865 0.1853
Brugia malayi neuropeptide F receptor 0.0017 0.0006 0.0006
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0134 0.0132
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.005 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.3332 0.333
Toxoplasma gondii aldehyde dehydrogenase 0.0196 0.0431 0.054
Mycobacterium tuberculosis Conserved hypothetical protein 0.0274 0.0614 0.5307
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0031 0.0283
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0029 0.0029
Echinococcus multilocularis neuropeptide receptor 0.0325 0.0734 0.0732
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0274 0.0614 0.0612
Loa Loa (eye worm) hypothetical protein 0.0078 0.0152 0.0152
Entamoeba histolytica hypothetical protein 0.0115 0.0238 0.0223
Trypanosoma brucei glucosidase, putative 0.0035 0.005 0.0046
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0006 0.0004
Onchocerca volvulus 0.0018 0.0009 0.0101
Leishmania major trypanothione reductase 0.0094 0.0188 0.0168
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0152 0.2297
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0059 0.0846
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.002 0.0017
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0274 0.0614 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.2512 0.5903 0.5902
Brugia malayi MH1 domain containing protein 0.0034 0.0047 0.0047
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.036 0.0818 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0803 0.1865 0.1863
Brugia malayi MH2 domain containing protein 0.0495 0.1137 0.1137
Plasmodium falciparum glutathione reductase 0.0094 0.0188 0.2891
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni alpha-glucosidase 0.0136 0.0288 0.0286
Giardia lamblia Hypothetical protein 0.0274 0.0614 0.0601
Loa Loa (eye worm) hypothetical protein 0.0026 0.0029 0.0029
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0213 0.0471 0.4055
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0123 0.0121
Schistosoma mansoni hypothetical protein 0.0018 0.0009 0.0006
Echinococcus granulosus fmrfamide receptor 0.0017 0.0006 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0152 0.015
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0274 0.0614 0.0601
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0006 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.002 0.0006
Entamoeba histolytica protein kinase, putative 0.003 0.0038 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0529 0.1217 0.1215
Trichomonas vaginalis PIKK family atypical protein kinase 0.3158 0.7429 0.7428
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0006 0.0004
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0006 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0274 0.0614 0.0614
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.002 0.0017
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0274 0.0614 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.005 0.0035
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0069 0.0049
Toxoplasma gondii sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein 0.0032 0.0043 0.0016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0152 0.1268
Loa Loa (eye worm) phosphatidylinositol 3 0.0274 0.0614 0.0614
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.002 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0152 0.0152
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.0333 0.0329
Schistosoma mansoni hypothetical protein 0.0114 0.0236 0.0234
Brugia malayi CXXC zinc finger family protein 0.0028 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0078 0.0152 0.0152
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0803 0.1865 0.1865
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0213 0.0471 0.4055
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0274 0.0614 0.0614
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0196 0.0431 0.0429
Loa Loa (eye worm) phosphatidylinositol kinase 0.0274 0.0614 0.0614
Mycobacterium ulcerans hypothetical protein 0.0172 0.0374 0.8655
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0114 0.0236 0.0234
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0059 0.0106 0.0092
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0043 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0237 0.0527 0.4546
Echinococcus granulosus orexin receptor type 2 0.0017 0.0006 0.0004
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0021 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0274 0.0614 0.0614
Brugia malayi beta-lactamase 0.0078 0.0152 0.0152
Brugia malayi G protein-coupled receptor 0.0017 0.0006 0.0006
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0131 0.0131
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0803 0.1865 0.1853
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0274 0.0614 0.0612
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0274 0.0614 0.0612
Entamoeba histolytica hypothetical protein 0.0115 0.0238 0.0223
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0019 0.0019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0043 0.0023
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0004
Onchocerca volvulus 0.0017 0.0006 0.0059
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0043 0.0484
Onchocerca volvulus 0.0017 0.0006 0.0059
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0006 0.0004
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0152 0.1268
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0152 0.015
Schistosoma mansoni adenoreceptor 0.0017 0.0006 0.0004
Schistosoma mansoni smad1 5 8 and 0.0034 0.0047 0.0044
Onchocerca volvulus 0.0016 0.0006 0.0053
Brugia malayi Inositol-1 0.0043 0.0069 0.0069
Loa Loa (eye worm) Smad1 0.0034 0.0047 0.0047
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.005 0.0035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0152 0.1268
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0152 0.0138
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0059 0.0106 0.0092
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0274 0.0614 0.0601
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0031 0.0017
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0274 0.0614 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.002 0.0017
Onchocerca volvulus 0.0016 0.0006 0.0053
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Onchocerca volvulus 0.0017 0.0006 0.0059
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.002 0.0116
Brugia malayi G-protein coupled receptor 0.0017 0.0006 0.0006
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0274 0.0614 0.0612
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.034 0.034
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0047 0.0077 0.0075
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0006 0.0004
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.0014 0.0012
Echinococcus multilocularis 0.0274 0.0614 0.0612
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0076 0.0146 0.0143
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.0431 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0019
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0043 0.0857
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0077 0.0075
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4246 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0006 0.0004
Leishmania major stearic acid desaturase, putative 0.0154 0.0331 0.0312
Echinococcus multilocularis dna polymerase eta 0.0023 0.002 0.0018
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.012 0.012
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4246 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0274 0.0614 0.0612
Leishmania major fatty-acid desaturase, putative 0.0154 0.0331 0.0312
Schistosoma mansoni alpha glucosidase 0.0035 0.005 0.0047
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0031 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.0439 0.0437
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0006 0.0004
Schistosoma mansoni amine GPCR 0.0017 0.0006 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0108 0.0106
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0069 0.0067
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0006 0.0004
Onchocerca volvulus 0.0154 0.0331 0.5378
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0032 0.0043 0.0023
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0043 0.0484
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.036 0.0818 0.0818
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0006 0.0004
Brugia malayi Cyclic-nucleotide gated cation channel 0.0015 0.0002 0.0002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0274 0.0614 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.3377 0.7947 0.7947
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.3332 0.333
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0415 0.0412
Echinococcus granulosus serotonin receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi RE15519p 0.0017 0.0006 0.0006
Onchocerca volvulus 0.0016 0.0006 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0649 0.0647
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0006 0.0004
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4246 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0006 0.0004
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0134 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.3377 0.7947 0.7947
Leishmania major mitochondrial DNA polymerase beta 0.0327 0.074 0.0721
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0047 0.0077 0.0075
Trichomonas vaginalis immunophilin, putative 0.0059 0.0106 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Schistosoma mansoni amine GPCR 0.0017 0.0006 0.0004
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0213 0.0471 0.764
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0047 0.0077 0.0063
Schistosoma mansoni neuropeptide receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0274 0.0614 0.0601
Onchocerca volvulus 0.0274 0.0614 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0006 0.0004
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0274 0.0614 0.0601
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0152 0.3422
Entamoeba histolytica hypothetical protein 0.0274 0.0614 0.0601
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0059 0.0106 0.2329
Brugia malayi Muscle positioning protein 4 0.0016 0.0006 0.0006
Onchocerca volvulus 0.0016 0.0006 0.0053
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0114 0.0236 0.0236
Plasmodium vivax hypothetical protein, conserved 0.0274 0.0614 1
Echinococcus granulosus GPCR family 2 0.0114 0.0236 0.0234
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0131 0.011
Echinococcus multilocularis lamin dm0 0.0026 0.0029 0.0026
Mycobacterium ulcerans lipase LipD 0.0078 0.0152 0.3422
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0415 0.0412
Schistosoma mansoni aldehyde dehydrogenase 0.0196 0.0431 0.0429
Schistosoma mansoni fatty acid desaturase 0.0032 0.0043 0.0041
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0274 0.0614 0.0601
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Brugia malayi putative neuropeptide receptor 0.0017 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.1424 0.3332 0.333
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0415 0.0412
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0529 0.1217 0.1204
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0004
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0006 0.0004
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1424 0.3332 0.333
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0106 0.0092
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.002 0.0006
Echinococcus granulosus serine protein kinase ATM 0.0803 0.1865 0.1863
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0006 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0415 0.0412
Schistosoma mansoni ferritin 0.0017 0.0007 0.0005
Brugia malayi MH2 domain containing protein 0.0034 0.0047 0.0047
Trypanosoma cruzi fatty acid desaturase, putative 0.0032 0.0043 0.0029
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0078 0.0152 0.0152
Echinococcus multilocularis MAM 0.0018 0.0009 0.0006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0006 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0123 0.0121
Echinococcus multilocularis ferritin 0.0017 0.0007 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0495 0.1137 0.1137
Loa Loa (eye worm) FKBP5 protein 0.0059 0.0106 0.0106
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0274 0.0614 0.0612
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3381 0.7955 0.7955
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0066 0.0122 0.0122
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0043 0.0318
Brugia malayi Melatonin receptor type 1A 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0152 0.1268
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0162 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0274 0.0614 0.0612
Plasmodium vivax glutathione reductase, putative 0.0094 0.0188 0.2891
Echinococcus multilocularis G protein coupled receptor 139 0.0325 0.0734 0.0732
Loa Loa (eye worm) hypothetical protein 0.0178 0.0388 0.0388
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4246 1 1
Entamoeba histolytica hypothetical protein 0.0115 0.0238 0.0223
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0006 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0006 0.0004
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0274 0.0614 0.0612
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0099 0.0085
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0006 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0189 0.0187
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0123 0.0123
Echinococcus multilocularis cpg binding protein 0.003 0.0037 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0238 0.0235
Loa Loa (eye worm) acyl-CoA desaturase 0.0122 0.0255 0.0255
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0274 0.0614 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0047 0.0077 0.0075
Onchocerca volvulus 0.0017 0.0006 0.0059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0274 0.0614 0.0614
Schistosoma mansoni cpg binding protein 0.0028 0.0033 0.0031
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0621 0.1434 0.1432
Brugia malayi sulfakinin receptor protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0152 0.0152
Echinococcus granulosus neuropeptide receptor 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0049 0.0082 0.0082
Echinococcus multilocularis sex peptide receptor 0.0017 0.0006 0.0004
Brugia malayi hypothetical protein 0.0018 0.0009 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0043 0.0857
Echinococcus multilocularis Zinc finger, PHD finger 0.0274 0.0614 0.0612
Toxoplasma gondii AGC kinase 0.003 0.0038 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0023 0.0023
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0803 0.1865 0.1863
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0213 0.0471 0.4055
Schistosoma mansoni neuropeptide receptor 0.0017 0.0006 0.0004
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0006 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.0439 0.0437
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.0014 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0078 0.0152 0.0152
Schistosoma mansoni amine GPCR 0.0017 0.0006 0.0004
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.034 0.0338
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0006 0.0004
Echinococcus multilocularis dnaJ subfamily B 0.04 0.0912 0.091
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.0032 0.0043 0.0848
Echinococcus granulosus g protein coupled receptor 0.0017 0.0006 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0274 0.0614 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.2289 0.5376 0.5375
Schistosoma mansoni neuropeptide receptor 0.0017 0.0006 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0529 0.1217 0.1215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable conserved membrane protein 0.0032 0.0043 0.0314
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0047 0.0077 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0649 0.0647
Entamoeba histolytica hypothetical protein 0.0274 0.0614 0.0601
Brugia malayi glutathione reductase 0.0094 0.0188 0.0188
Echinococcus granulosus lamin dm0 0.0026 0.0029 0.0026
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0006 0.0004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0043 0.0043
Onchocerca volvulus 0.0078 0.0152 0.2448
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.002 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0019 0.0016
Schistosoma mansoni smad1 5 8 and 0.0034 0.0047 0.0044
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1424 0.3332 0.333
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0076 0.0146 0.0143
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0043 0.0041
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0043 0.0041
Mycobacterium tuberculosis Conserved protein 0.0078 0.0152 0.1268
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0006 0.0006
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0043 0.0484
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium ulcerans beta-lactamase 0.0078 0.0152 0.3422
Schistosoma mansoni apoferritin-2 0.0017 0.0007 0.0005
Schistosoma mansoni immunophilin 0.0059 0.0106 0.0104
Echinococcus multilocularis ubiquitin specific protease 41 0.0047 0.0077 0.0075
Schistosoma mansoni hypothetical protein 0.053 0.1218 0.1216
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.0374 0.3208
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0274 0.0614 0.0612
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0006 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.005 0.0047
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0131 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.2512 0.5903 0.5902
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0114 0.0236 0.0234
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni biogenic amine receptor 0.0017 0.0006 0.0004
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0106 0.0102
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0047 0.0047
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Onchocerca volvulus 0.0017 0.0006 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.005 0.0047
Onchocerca volvulus 0.0016 0.0006 0.0053
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0006 0.0006
Echinococcus multilocularis tumor protein p63 0.0333 0.0754 0.0752
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Schistosoma mansoni biogenic amine receptor 0.0017 0.0006 0.0004
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Leishmania major delta-4 fatty acid desaturase 0.0032 0.0043 0.0023
Loa Loa (eye worm) DOMON domain-containing protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0114 0.0236 0.0236
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0043 0.0029
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.002 0.0018
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0123 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0006
Onchocerca volvulus 0.0028 0.0033 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.3377 0.7947 0.7947
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0188 0.158
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.002 0.0006
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0803 0.1865 0.1863
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0274 0.0614 0.0612
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.3158 0.7429 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.0614 0.0612
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0006 0.0004
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0006 0.0004
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0106 0.1524
Leishmania major delta-6 fatty acid desaturase 0.0032 0.0043 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0006 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0006 0.0006
Brugia malayi MH1 domain containing protein 0.0034 0.0047 0.0047
Echinococcus multilocularis nervana 2 0.002 0.0014 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0415 0.0412
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0621 0.1434 0.1432
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.005 0.0035
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0029 0.0029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0152 0.3422
Echinococcus multilocularis musashi 0.0026 0.0029 0.0026
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0274 0.0614 0.0612
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0152 0.1268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.0439 0.0437
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0274 0.0614 0.0601
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0213 0.0471 0.4055
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0003 0.0003
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0274 0.0614 0.0612
Onchocerca volvulus 0.0017 0.0006 0.0059
Loa Loa (eye worm) hypothetical protein 0.0051 0.0087 0.0087
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0047 0.0077 0.0075
Leishmania major hypothetical protein, unknown function 0.0274 0.0614 0.0595
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0152 0.015
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0106 0.0104
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0032 0.0043 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0274 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.3158 0.7429 0.7428
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.002 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.0439 0.0437
Entamoeba histolytica hypothetical protein 0.0274 0.0614 0.0601
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.005 0.0047
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0006 0.0004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0006 0.0006
Leishmania major phosphatidylinositol 3-kinase, putative 0.0274 0.0614 0.0595
Leishmania major phosphatidylinositol 3-kinase, putative 0.1424 0.3332 0.3318
Loa Loa (eye worm) hypothetical protein 0.0047 0.0077 0.0077
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.3377 0.7947 0.7947
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0274 0.0614 0.0612
Leishmania major delta-5 fatty acid desaturase 0.0032 0.0043 0.0023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1424 0.3332 0.3322
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0649 0.0647
Trypanosoma brucei delta-4 fatty acid desaturase 0.0032 0.0043 0.0039
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0059 0.0106 0.0104
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.002 0.0018
Echinococcus multilocularis lamin 0.0026 0.0029 0.0026
Leishmania major hypothetical protein, conserved 0.0274 0.0614 0.0595
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0006 0.0004
Trypanosoma cruzi target of rapamycin kinase 3 0.3381 0.7955 0.7952
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0047 0.0047
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0274 0.0614 0.0601
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0006 0.0004
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0274 0.0614 0.0601
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0047 0.0044
Leishmania major phosphatidylinositol kinase, putative 0.0274 0.0614 0.0595
Schistosoma mansoni intermediate filament proteins 0.0026 0.0029 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.0274 0.0614 0.0614
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0803 0.1865 0.1853
Entamoeba histolytica hypothetical protein 0.0274 0.0614 0.0601
Entamoeba histolytica hypothetical protein 0.0803 0.1865 0.1853
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0019 0.0016
Echinococcus granulosus nervana 2 0.002 0.0014 0.0012
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0274 0.0614 0.0614
Echinococcus granulosus Smad4 0.0034 0.0047 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0006 0.0004
Leishmania major phosphatidylinositol 4-kinase, putative 0.0274 0.0614 0.0595
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2008 0.4712 0.471
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0006 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0006 0.0004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0237 0.0527 0.8566
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0006 0.0004
Loa Loa (eye worm) RNA binding protein 0.0066 0.0123 0.0123
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0188 0.0188
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4246 1 1
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Trypanosoma cruzi fatty acid desaturase, putative 0.0032 0.0043 0.0029
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0006 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0152 0.015
Onchocerca volvulus 0.0017 0.0006 0.0059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1424 0.3332 0.3332
Mycobacterium tuberculosis Probable oxidoreductase 0.0237 0.0527 0.4546
Echinococcus granulosus hypothetical protein 0.0017 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.2757 0.648 0.6479
Toxoplasma gondii hypothetical protein 0.0053 0.0092 0.0081

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
GI50 (functional) -6.483 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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