Detailed information for compound 1647153

Basic information

Technical information
  • TDR Targets ID: 1647153
  • Name: N-[(1-prop-2-ynylindol-3-yl)methylideneamino] -1H-benzimidazol-2-amine
  • MW: 313.356 | Formula: C19H15N5
  • H donors: 2 H acceptors: 1 LogP: 3.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCn1cc(c2c1cccc2)/C=N/Nc1nc2c([nH]1)cccc2
  • InChi: 1S/C19H15N5/c1-2-11-24-13-14(15-7-3-6-10-18(15)24)12-20-23-19-21-16-8-4-5-9-17(16)22-19/h1,3-10,12-13H,11H2,(H2,21,22,23)/b20-12+
  • InChiKey: NPAVTJZLYJPBCP-UDWIEESQSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(1-prop-2-ynylindol-3-yl)methyleneamino]-1H-benzimidazol-2-amine
  • N-[(1-prop-2-ynyl-3-indolyl)methyleneamino]-1H-benzimidazol-2-amine
  • 1H-benzimidazol-2-yl-[(1-propargylindol-3-yl)methyleneamino]amine
  • 1-prop-2-ynyl-1H-indole-3-carbaldehyde 1H-benzimidazol-2-ylhydrazone
  • MLS000585668
  • SMR000204231
  • STK256916

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0021 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.4161 0.648 0.6478
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0046 0.0043
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0425 0.0637 0.0621
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0447 0.0672 0.0669
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0425 0.0637 0.0637
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0198 0.0198
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0162 0.016
Echinococcus multilocularis lamin 0.0033 0.0024 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.2181 0.3384 0.338
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Giardia lamblia Phosphatidylinositol 4-kinase 0.0425 0.0637 0.0632
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0.0006 0.0005
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0447 0.0672 0.0666
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0017 0.0214
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0003 0.0000048739
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0121 0.0162 0.016
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.0006 0.0004
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0023 0.0017
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6411 1 1
Leishmania major cyclic nucleotide-binding protein-like protein 0.0021 0.0006 0.0004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0017 0.0236
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0021 0.0006 0.0004
Leishmania major protein kinase, putative 0.0021 0.0006 0.0004
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0006 0.0054
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0162 0.016
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.0846 0.0844
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2193 0.3403 0.3401
Leishmania major peptidylprolyl isomerase-like protein 0.0121 0.0162 0.016
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6411 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0021 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.5109 0.7963 0.7962
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3024 0.4702 0.4701
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0447 0.0672 0.0669
Loa Loa (eye worm) hypothetical protein 0.056 0.0849 0.0849
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0162 0.016
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0121 0.0162 0.0146
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0017 0.0235
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.0006 0.0004
Trypanosoma cruzi cAMP binding protein, putative 0.0021 0.0006 0.0004
Mycobacterium tuberculosis Conserved protein 0.0021 0.0006 0.0056
Leishmania major fk506-binding protein 1-like protein 0.0121 0.0162 0.016
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0425 0.0637 0.9484
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.013 0.0127
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1233 0.1901 0.1899
Loa Loa (eye worm) phosphatidylinositol 3 0.2193 0.3403 0.3403
Loa Loa (eye worm) FKBP5 protein 0.0121 0.0162 0.0162
Echinococcus granulosus dnaJ subfamily B 0.0494 0.0745 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.3484 0.5421 0.5418
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1233 0.1901 0.1901
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0447 0.0672 0.0899
Leishmania major hypothetical protein, unknown function 0.0425 0.0637 0.0635
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0516 0.0779 0.0764
Trichomonas vaginalis PIKK family atypical protein kinase 0.6411 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0425 0.0637 0.0637
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0492 0.0742 0.074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0023
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0425 0.0637 0.9484
Echinococcus multilocularis fk506 binding protein 0.0121 0.0162 0.016
Loa Loa (eye worm) glutaminase 2 0.033 0.0489 0.0489
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0638 0.097 0.0965
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.047 0.0707 0.0702
Leishmania major phosphatidylinositol kinase related protein, putative 0.0425 0.0637 0.0635
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1233 0.1901 0.1899
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0425 0.0637 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.5109 0.7963 0.7962
Echinococcus granulosus serine protein kinase ATM 0.1233 0.1901 0.1899
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0121 0.0162 0.0162
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0447 0.0672 0.0669
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0023 0.002
Trypanosoma cruzi target of rapamycin kinase 3 0.5114 0.7972 0.7971
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0023 0.002
Giardia lamblia Hypothetical protein 0.0425 0.0637 0.0632
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0425 0.0637 0.0637
Schistosoma mansoni immunophilin 0.0104 0.0136 0.0134
Loa Loa (eye worm) hypothetical protein 0.0047 0.0046 0.0046
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0021 0.0006 0.0004
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2238 0.3472 0.3471
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0023 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.3832 0.5966 0.5964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0425 0.0637 0.0632
Loa Loa (eye worm) phosphatidylinositol 3 0.6411 1 1
Schistosoma mansoni hypothetical protein 0.0494 0.0745 0.0743
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0021 0.0006 0.0004
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0006 0.0057
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0017 0.0017
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0017 0.0019
Trypanosoma cruzi protein kinase A regulatory subunit 0.0021 0.0006 0.0004
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0524 0.0793 0.0787
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0017 0.0236
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0046 0.0043
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0569 0.0863 0.0857
Entamoeba histolytica hypothetical protein 0.0425 0.0637 0.0621
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0046 0.0043
Giardia lamblia GTOR 0.6411 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0151 0.0209 0.0203
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0021 0.0006 0.0004
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0121 0.0162 0.016
Echinococcus granulosus cGMP dependent protein kinase 0.0021 0.0006 0.0004
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.056 0.0849 0.0847
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2238 0.3472 0.3471
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0151 0.0209 0.0203
Schistosoma mansoni immunophilin 0.0121 0.0162 0.016
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0447 0.0672 0.0669
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2238 0.3472 0.3471
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0104 0.0136 0.0134
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0021 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.5109 0.7963 0.7962
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0003 0.0003
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0447 0.0672 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.2181 0.3384 0.338
Trypanosoma cruzi cAMP response protein 1 0.0021 0.0006 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0017 0.0015
Trypanosoma cruzi Flagellar Member 6 0.0021 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0425 0.0637 0.9484
Trypanosoma cruzi cAMP response protein 1, putative 0.0021 0.0006 0.0004
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0447 0.0672 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0447 0.0672 0.0669
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0004 0.0028
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0023 0.002
Echinococcus multilocularis Zinc finger, PHD finger 0.0447 0.0672 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.4781 0.7449 0.7448
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0021 0.0006 0.0005
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0425 0.0637 0.9484
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0121 0.0162 0.0162
Toxoplasma gondii target of rapamycin (TOR), putative 0.4781 0.7449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4781 0.7449 0.7448
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0425 0.0637 0.0852
Schistosoma mansoni voltage-gated potassium channel 0.0177 0.0249 0.0246
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0021 0.0006 0.0004
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0017 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.1373 0.212 0.2116
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0003 0.0000048739
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0017 0.0015
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6411 1 1
Trichomonas vaginalis immunophilin, putative 0.0121 0.0162 0.0156
Trypanosoma brucei cAMP response protein 1, putative 0.0021 0.0006 0.0004
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0121 0.0162 0.0162
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0425 0.0637 0.0852
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0006 0.0001
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0638 0.097 0.0965
Brugia malayi CXXC zinc finger family protein 0.0035 0.0027 0.0027
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0162 0.0226 0.0226
Loa Loa (eye worm) phosphatidylinositol 3 0.0425 0.0637 0.0637
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0638 0.097 0.0968
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0213 0.0306 0.0289
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0023 0.002
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0021 0.0006 0.0053
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0017
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6411 1 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0948 0.1456 0.1454
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0006 0.0004
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0425 0.0637 0.0852
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.013 0.013
Echinococcus granulosus cpg binding protein 0.0037 0.003 0.0028
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1373 0.212 0.2844
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1245 0.192 0.1906
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0425 0.0637 0.0635
Loa Loa (eye worm) phosphatidylinositol kinase 0.0425 0.0637 0.0637
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0638 0.097 0.0965
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0017 0.0214
Brugia malayi FAT domain containing protein 0.0948 0.1456 0.1456
Onchocerca volvulus 0.0425 0.0637 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0023 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.4781 0.7449 0.7448
Loa Loa (eye worm) phosphatidylinositol 3 0.0425 0.0637 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.4301 0.6699 0.6697
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0021 0.0006 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0017 0.0235
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0021 0.0006 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0003 0.0000048739
Brugia malayi Egg laying defective protein 4 0.0021 0.0006 0.0006
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0425 0.0637 0.9484
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1233 0.1901 0.1899
Trichomonas vaginalis PIKK family atypical protein kinase 0.4781 0.7449 0.7448
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0492 0.0742 0.0736
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0023 0.002
Schistosoma mansoni intermediate filament proteins 0.0033 0.0024 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.0786 0.1202 0.1202
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1233 0.1901 0.1901
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0021 0.0006 0.0004
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0121 0.0162 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0017 0.0001
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0.0006 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.0846 0.0844
Trichomonas vaginalis glutaminase, putative 0.033 0.0489 0.0483
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.056 0.0849 0.0847
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0021 0.0006 0.0004
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0425 0.0637 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.3478 0.5413 0.541
Echinococcus multilocularis cpg binding protein 0.0037 0.003 0.0028
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0021 0.0006 0.0056
Leishmania major phosphatidylinositol kinase, putative 0.0425 0.0637 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.5109 0.7963 0.7962
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0047 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.3484 0.5421 0.5418
Echinococcus multilocularis tumor protein p63 0.0408 0.0611 0.0609
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0425 0.0637 0.0635
Schistosoma mansoni lamin 0.0033 0.0024 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.2193 0.3403 0.3399
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0027 0.0027
Entamoeba histolytica protein kinase rad3, putative 0.1233 0.1901 0.1888
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0006 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0046 0.0043
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0447 0.0672 0.0669
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0121 0.0162 0.2385
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0569 0.0863 0.0857
Echinococcus multilocularis expressed conserved protein 0.0021 0.0006 0.0004
Echinococcus multilocularis geminin 0.0205 0.0293 0.029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0017
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0017 1
Onchocerca volvulus 0.0033 0.0024 0.0278
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0017 0.0236
Leishmania major protein kinase A regulatory subunit, putative 0.0021 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0948 0.1456 0.1454
Trichomonas vaginalis PIKK family atypical protein kinase 0.1245 0.192 0.1915
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0013 0.001
Schistosoma mansoni hypothetical protein 0.0205 0.0293 0.029
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0075 0.0098
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0104 0.0136 0.0134
Loa Loa (eye worm) AGC/PKG protein kinase 0.0021 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0021 0.0006 0.0004
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0021 0.0006 0.0006
Trypanosoma brucei cAMP binding protein, putative 0.0021 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0023
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0425 0.0637 0.0635
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0121 0.0162 0.0146
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0831 0.1272 0.127
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0808 0.1237 0.1234
Loa Loa (eye worm) hypothetical protein 0.1297 0.2001 0.2001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0003 0.0000048739
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0121 0.0162 0.2385
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0593 0.09 0.0885
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0067 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0425 0.0637 0.0637
Leishmania major regulatory subunit of protein kinase a-like protein 0.0021 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.3812 0.5935 0.5932
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0017 0.0236
Onchocerca volvulus 0.006 0.0066 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.1722 0.2666 0.2661
Echinococcus granulosus intermediate filament protein 0.0033 0.0024 0.0021
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0021 0.0006 0.0006
Schistosoma mansoni glutaminase 0.033 0.0489 0.0487
Loa Loa (eye worm) hypothetical protein 0.0104 0.0136 0.0136
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0492 0.0742 0.0736
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0067 0.0067
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0021 0.0006 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0017 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0017 0.018
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0017 0.5
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0017 0.0223
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0021 0.0006 0.0004
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0024 0.0024
Loa Loa (eye worm) phosphatidylinositol 3 0.0067 0.0077 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0004 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.1233 0.1901 0.1896
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0006 0.0054
Loa Loa (eye worm) hypothetical protein 0.01 0.013 0.013
Leishmania major phosphatidylinositol 3-kinase, putative 0.0447 0.0672 0.0669
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0003 0.0003
Leishmania major hypothetical protein, unknown function 0.0021 0.0006 0.0004
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0425 0.0637 0.0621
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0638 0.097 0.097
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0492 0.0742 0.0726
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2193 0.3403 0.3401
Echinococcus granulosus patatin phospholipase domain containing protein 0.0021 0.0006 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0492 0.0742 0.0742
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6411 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0006 0.0004
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0447 0.0672 0.0656
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0447 0.0672 0.0666
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0023 0.002
Schistosoma mansoni hypothetical protein 0.0205 0.0293 0.029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0425 0.0637 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.5463 0.8517 0.8516
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0003 0.0003
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0021 0.0006 0.0004
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0023 0.0023
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0425 0.0637 0.0632
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0447 0.0672 0.0899
Trichomonas vaginalis PIKK family atypical protein kinase 0.5109 0.7963 0.7962
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1504 0.1502
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0017 0.0236
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0023 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0037 0.0037
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1233 0.1901 0.1899
Leishmania major hypothetical protein, conserved 0.0021 0.0006 0.0004
Trypanosoma brucei Flagellar Member 6 0.0021 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.4781 0.7449 0.7448
Trichomonas vaginalis PIKK family atypical protein kinase 0.3484 0.5421 0.5418
Trichomonas vaginalis conserved hypothetical protein 0.0808 0.1237 0.1231
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0712 0.1086 0.1084
Trichomonas vaginalis PIKK family atypical protein kinase 0.3484 0.5421 0.5418
Echinococcus multilocularis serine protein kinase ATM 0.1233 0.1901 0.1899
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6411 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.4781 0.7449 0.7448
Loa Loa (eye worm) phosphatidylinositol 3 0.0425 0.0637 0.0637
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0023 0.002
Plasmodium falciparum cGMP-dependent protein kinase 0.0021 0.0006 0.0053
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0021 0.0006 0.0004
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0425 0.0637 0.9484
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0162 0.0226 0.0223
Plasmodium vivax hypothetical protein 0.0425 0.0637 0.9484
Schistosoma mansoni immunophilin 0.0121 0.0162 0.016
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0021 0.0006 0.0004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0638 0.097 0.0955
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0121 0.0162 0.0156
Leishmania major hypothetical protein, conserved 0.0527 0.0796 0.0794
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0021 0.0006 0.0056
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0017 0.0226
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0447 0.0672 0.0672
Loa Loa (eye worm) hypothetical protein 0.0948 0.1456 0.1456
Trichomonas vaginalis PIKK family atypical protein kinase 0.3832 0.5966 0.5964
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0017
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0948 0.1456 0.1454
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0017 0.0236
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0638 0.097 0.0968
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0066 0.0064
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.3812 0.5935 0.5932
Echinococcus granulosus geminin 0.0205 0.0293 0.029
Leishmania major phosphatidylinositol 4-kinase, putative 0.0425 0.0637 0.0635
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.0745 0.0743
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0193 0.0275 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0808 0.1237 0.1231
Entamoeba histolytica hypothetical protein 0.0593 0.09 0.0885
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0425 0.0637 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.3478 0.5413 0.541
Leishmania major phosphatidylinositol 3-kinase, putative 0.2181 0.3384 0.3383
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2238 0.3472 0.3471
Schistosoma mansoni voltage-gated potassium channel 0.0177 0.0249 0.0246
Leishmania major protein kinase, putative 0.0021 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1233 0.1901 0.1896
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0121 0.0162 0.0156
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0447 0.0672 0.0669
Entamoeba histolytica hypothetical protein 0.0425 0.0637 0.0621
Echinococcus granulosus neuropeptide s receptor 0.0558 0.0846 0.0844
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0121 0.0162 0.016
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0.0006 0.0005
Brugia malayi MH2 domain containing protein 0.0144 0.0198 0.0198
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0162 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.1373 0.212 0.212
Schistosoma mansoni lamin 0.0033 0.0024 0.0021
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0017 0.0223
Onchocerca volvulus 0.0029 0.0017 0.018
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0121 0.0162 0.3232
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0425 0.0637 0.0635
Loa Loa (eye worm) hypothetical protein 0.0077 0.0094 0.0094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0067 0.0067
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0017 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0948 0.1456 0.1451
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0017 0.0001
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1233 0.1901 0.1899
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0162 0.0226 0.0226
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0006 0.0004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0017 0.0236
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6411 1 1
Loa Loa (eye worm) hypothetical protein 0.1233 0.1901 0.1901
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0024 0.0024
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0425 0.0637 0.0635
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2238 0.3472 0.3471
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0004 0.0028
Schistosoma mansoni cpg binding protein 0.0035 0.0027 0.0024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2238 0.3472 0.3472
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0492 0.0742 0.0739
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1233 0.1901 0.1899
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0021 0.0006 0.0006
Schistosoma mansoni cpg binding protein 0.0037 0.003 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.6411 1 1
Echinococcus multilocularis 0.0425 0.0637 0.0635
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0492 0.0742 0.0736
Mycobacterium ulcerans hypothetical protein 0.0029 0.0017 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.3478 0.5413 0.541
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0021 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.3832 0.5966 0.5964
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0447 0.0672 0.0666
Echinococcus granulosus lamin 0.0033 0.0024 0.0021
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0121 0.0162 0.0156
Loa Loa (eye worm) glutaminase 0.033 0.0489 0.0489
Onchocerca volvulus 0.0035 0.0027 0.033
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0021 0.0006 0.0004
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5114 0.7972 0.7971
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0006 0.0004
Brugia malayi N-terminal motif family protein 0.0021 0.0006 0.0006
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0023 0.002
Toxoplasma gondii FATC domain-containing protein 0.1233 0.1901 0.255
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0831 0.1272 0.127
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0425 0.0637 0.0632
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0023 0.0017
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0006 0.0059
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0006 0.0056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.056 0.0849 0.0849
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0021 0.0006 0.0004
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0023 0.002
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0021 0.0006 0.0053
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0447 0.0672 0.0669
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.0846 0.0844
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0425 0.0637 0.0635
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0162 0.016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0088 0.0085
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0003 0.0000048739
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6411 1 1
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0021 0.0006 0.0005
Echinococcus multilocularis lamin dm0 0.0033 0.0024 0.0021
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6411 1 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0017 0.0017
Echinococcus granulosus tumor protein p63 0.0408 0.0611 0.0609
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0023 0.002
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0017 0.0001
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0021 0.0006 0.0004
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0003 0.0000048739
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0004 0.0028
Schistosoma mansoni cpg binding protein 0.0037 0.003 0.0028
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0425 0.0637 0.0635
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5114 0.7972 0.7971
Brugia malayi glutaminase DH11.1 0.033 0.0489 0.0489
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0021 0.0006 0.0053
Entamoeba histolytica hypothetical protein 0.1233 0.1901 0.1888
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0023 0.002
Trichomonas vaginalis fk506-binding protein, putative 0.0121 0.0162 0.0156
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0121 0.0162 0.0156
Echinococcus granulosus cGMP dependent protein kinase 1 0.0021 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.4781 0.7449 0.7448
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0021 0.0006 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0003 0.0000048739
Schistosoma mansoni 60S ribosomal protein L21 0.0025 0.0013 0.001
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0023 0.002
Onchocerca volvulus 0.0425 0.0637 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0425 0.0637 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0024 0.0024
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0447 0.0672 0.0656
Onchocerca volvulus 0.01 0.013 0.1959
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0021 0.0006 0.0004
Echinococcus granulosus lamin dm0 0.0033 0.0024 0.0021
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0017 0.0171
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0067 0.0067
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0017 0.0014
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0425 0.0637 0.0635
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0712 0.1086 0.1084
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0.0006 0.0005
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0023 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0425 0.0637 0.0632
Mycobacterium ulcerans glutaminase 0.033 0.0489 1
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0021 0.0006 0.0056
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0425 0.0637 0.0635
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.6411 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0017 0.018
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0023 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0132 0.0129
Echinococcus granulosus cGMP dependent protein kinase 1 0.0021 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0808 0.1237 0.1237
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0021 0.0006 0.0004
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2181 0.3384 0.3383
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0035
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0425 0.0637 0.0635
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0003 0.0003
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0021 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0425 0.0637 0.0635
Mycobacterium leprae conserved hypothetical protein 0.0425 0.0637 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.1233 0.1901 0.1899
Trypanosoma brucei protein kinase A regulatory subunit 0.0021 0.0006 0.0004
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0492 0.0742 0.0739
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0017 0.0014
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0121 0.0162 0.016
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0447 0.0672 0.0672
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6411 1 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.013 0.0127
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0425 0.0637 0.0635
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2675 0.4157 0.4155
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0162 0.016
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0447 0.0672 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.2181 0.3384 0.338
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0046 0.0043
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0017 0.0015
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0046 0.0043
Onchocerca volvulus 0.0033 0.0024 0.0278
Leishmania major hypothetical protein, conserved 0.0021 0.0006 0.0004
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0021 0.0006 0.0004
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0006 0.0004
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0425 0.0637 0.0635
Brugia malayi intermediate filament protein 0.0033 0.0024 0.0024
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0162 0.0226 0.0223
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0831 0.1272 0.127
Echinococcus multilocularis musashi 0.0033 0.0024 0.0021
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0021 0.0006 0.0004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0492 0.0742 0.0726
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6411 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2181 0.3384 0.338
Loa Loa (eye worm) hypothetical protein 0.014 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.006 0.0067 0.0067

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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