TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 514.572 | Formula: C29H30N4O5
H donors: 3 H acceptors: 5 LogP: 4.53 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: OCCNC(=O)COc1ccc(cc1)n1nc(cc1NC(=O)C(=O)c1cccc2c1cccc2)C(C)(C)C
InChi: 1S/C29H30N4O5/c1-29(2,3)24-17-25(31-28(37)27(36)23-10-6-8-19-7-4-5-9-22(19)23)33(32-24)20-11-13-21(14-12-20)38-18-26(35)30-15-16-34/h4-14,17,34H,15-16,18H2,1-3H3,(H,30,35)(H,31,37)
InChiKey: CCGONFUHNLRGRE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin-dependent kinase 8	Starlite/ChEMBL	No references
Homo sapiens	Pim-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	No references
Homo sapiens	Bruton agammaglobulinemia tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	anaplastic lymphoma receptor tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	protein tyrosine kinase 2	Starlite/ChEMBL	No references
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	No references
Homo sapiens	TAO kinase 1	Starlite/ChEMBL	No references
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	FYN proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	LIM domain kinase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Onchocerca volvulus	Serine\/threonine protein kinase homolog	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	dual specificity testis specific protein kinase	Get druggable targets OG5_131191	All targets in OG5_131191
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	Cyclin-dependent serine/threonin protein kinase	Get druggable targets OG5_129229	All targets in OG5_129229
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma japonicum	ko:K02208 cyclin-dependent kinase 8/11, putative	Get druggable targets OG5_129229	All targets in OG5_129229
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	Get druggable targets OG5_129521	All targets in OG5_129521
Loa Loa (eye worm)	CMGC/CDK/CDK8 protein kinase	Get druggable targets OG5_129229	All targets in OG5_129229
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Loa Loa (eye worm)	TK/ALK protein kinase	Get druggable targets OG5_132231	All targets in OG5_132231
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129521	All targets in OG5_129521
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132231	All targets in OG5_132231
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus granulosus	protein tyrosine kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K05743 LIM domain kinase 1, putative	Get druggable targets OG5_131191	All targets in OG5_131191
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	protein tyrosine kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	Protein tyrosine kinase 2 beta, putative	Get druggable targets OG5_130513	All targets in OG5_130513
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129229	All targets in OG5_129229
Loa Loa (eye worm)	gastrulation defective protein 1	Get druggable targets OG5_129229	All targets in OG5_129229
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	Cyclin-dependent serine/threonin protein kinase	Get druggable targets OG5_129229	All targets in OG5_129229
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	Serine/threonine-protein kinase SULU	Get druggable targets OG5_129521	All targets in OG5_129521
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Loa Loa (eye worm)	TK/FAK protein kinase	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus multilocularis	serine:threonine protein kinase TAO1	Get druggable targets OG5_129521	All targets in OG5_129521
Schistosoma japonicum	ko:K04429 thousand and one amino acid protein kinase, putative	Get druggable targets OG5_129521	All targets in OG5_129521
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_134863	All targets in OG5_134863
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	serine:threonine protein kinase TAO1	Get druggable targets OG5_129521	All targets in OG5_129521
Brugia malayi	hypothetical protein	Get druggable targets OG5_129521	All targets in OG5_129521
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	dual specificity testis-specific protein kinase	Get druggable targets OG5_131191	All targets in OG5_131191
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	protein kinase	Get druggable targets OG5_131191	All targets in OG5_131191
Brugia malayi	Serine/threonine-protein kinase Pim-3	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129229	All targets in OG5_129229
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_132231	All targets in OG5_132231
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	cyclin dependent kinase 19	Get druggable targets OG5_129229	All targets in OG5_129229
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	cyclin dependent kinase 19	Get druggable targets OG5_129229	All targets in OG5_129229
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_130513	All targets in OG5_130513
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	protein kinase	Get druggable targets OG5_131191	All targets in OG5_131191

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.021	0.0538
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.033	0.085
Echinococcus multilocularis	SH2 motif	0.0012	0.003	0.0029
Echinococcus multilocularis	nostrin	0.0012	0.0026	0.0025
Onchocerca volvulus		0.0035	0.0327	0.1067
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.161	0.1904
Echinococcus granulosus	growth factor receptor bound protein 2	0.0024	0.018	0.0212
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0012	0.003	0.0014
Onchocerca volvulus		0.0034	0.0308	0.1001
Loa Loa (eye worm)	SH2 domain-containing protein	0.0012	0.003	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Schistosoma mansoni	hypothetical protein	0.0675	0.8449	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0257	0.0255
Echinococcus multilocularis	pyruvate kinase	0.0036	0.033	0.0329
Loa Loa (eye worm)	guanylate kinase	0.0014	0.0057	0.0144
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0397	0.0468
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0327	0.085
Echinococcus granulosus	SH2 motif	0.0012	0.003	0.0034
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0327	0.1162
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0066	0.0719	0.0718
Brugia malayi	Pre-SET motif family protein	0.0205	0.2482	0.6409
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0012	0.003	0.0074
Brugia malayi	transcription factor E74 isoform	0.0011	0.0018	0.0046
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Schistosoma mansoni	hypothetical protein	0.0175	0.2105	0.2484
Onchocerca volvulus		0.0019	0.0122	0.034
Echinococcus multilocularis	protein patched	0.0041	0.0397	0.0395
Echinococcus granulosus	lamin dm0	0.0026	0.021	0.0247
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0327	0.1752
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.1089	0.1288
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0012	0.003	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0064
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0012	0.0026	0.0025
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0397	0.0395
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.048	0.1235
Entamoeba histolytica	hypothetical protein	0.0013	0.0047	0.0197
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0012	0.003	0.0074
Brugia malayi	Latrophilin receptor protein 2	0.0081	0.0908	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0327	0.084
Echinococcus granulosus	GPCR family 2	0.0081	0.0908	0.1073
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2082	0.582
Plasmodium vivax	SET domain protein, putative	0.003	0.0257	0.3586
Mycobacterium ulcerans	glutaminase	0.029	0.3558	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0521	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0019	0.0122	0.0121
Onchocerca volvulus		0.0019	0.0122	0.034
Leishmania major	hypothetical protein, conserved	0.0012	0.0026	0.0103
Echinococcus multilocularis	musashi	0.0026	0.021	0.0208
Echinococcus granulosus	nostrin	0.0012	0.0026	0.0029
Echinococcus granulosus	ETS transcription factor Elf 1	0.0011	0.0018	0.0019
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0066	0.0719	0.085
Schistosoma mansoni	cpg binding protein	0.003	0.0257	0.0296
Toxoplasma gondii	pyruvate kinase PyK1	0.0036	0.033	0.5209
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Onchocerca volvulus		0.0028	0.0237	0.0747
Brugia malayi	Variant SH3 domain containing protein	0.0024	0.018	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0327	0.084
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0024	0.018	0.0179
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0012	0.003	0.0027
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.2341	0.6044
Echinococcus multilocularis	NCK adaptor protein	0.0024	0.018	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0204	0.0523
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0265	0.3237	0.8358
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0012	0.0026	0.0029
Echinococcus granulosus	tyrosine protein kinase Srms	0.0019	0.0122	0.0143
Loa Loa (eye worm)	hypothetical protein	0.004	0.038	0.0977
Echinococcus granulosus	cyclin dependent kinase 19	0.016	0.1904	0.2252
Echinococcus granulosus	lamin	0.0026	0.021	0.0247
Schistosoma mansoni	shc transforming protein	0.0012	0.003	0.0027
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0011	0.0014	0.0035
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0066	0.0719	0.0718
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.3237	0.9093
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.038	0.2044
Loa Loa (eye worm)	D-ets-2 protein	0.0011	0.0018	0.0042
Echinococcus granulosus	tyrosine kinase	0.0019	0.0122	0.0143
Echinococcus multilocularis	ubiquitin specific protease 41	0.004	0.038	0.0378
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0081	0.0908	0.234
Loa Loa (eye worm)	glutaminase	0.029	0.3558	0.9185
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.3237	0.9093
Brugia malayi	hypothetical protein	0.0019	0.0122	0.0315
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0327	0.1162
Brugia malayi	SH2 domain containing protein	0.0012	0.003	0.0078
Brugia malayi	hypothetical protein	0.0229	0.279	0.7205
Schistosoma mansoni	pyruvate kinase	0.0036	0.033	0.0382
Schistosoma mansoni	hypothetical protein	0.0081	0.0908	0.1066
Leishmania major	hypothetical protein, conserved	0.0051	0.0521	0.2817
Onchocerca volvulus		0.0035	0.0327	0.1067
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0011	0.0018	0.0016
Brugia malayi	Protein kinase domain containing protein	0.0315	0.3873	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0012	0.003	0.0034
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0012	0.003	0.0078
Loa Loa (eye worm)	TK/ABL protein kinase	0.0019	0.0122	0.0311
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0066	0.0719	0.0718
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.033	0.085
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0327	0.1162
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0012	0.003	0.0029
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0327	0.1162
Brugia malayi	Spectrin alpha chain	0.0012	0.0026	0.0068
Schistosoma mansoni	elf1	0.0011	0.0018	0.0012
Loa Loa (eye worm)	gastrulation defective protein 1	0.0157	0.1876	0.4841
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0521	0.8276
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0189	0.2275	0.2686
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0118	0.0131
Trypanosoma brucei	pyruvate kinase 1, putative	0.0036	0.033	0.1773
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0012	0.003	0.0078
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0229	0.279	0.7204
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0327	0.1162
Brugia malayi	Peripheral plasma membrane protein CASK	0.0014	0.0057	0.0148
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0116	0.0296
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0627	0.0734
Echinococcus multilocularis	expressed protein	0.0012	0.0026	0.0025
Loa Loa (eye worm)	TK protein kinase	0.0055	0.0569	0.1466
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Echinococcus multilocularis	cyclin dependent kinase 19	0.016	0.1904	0.1903
Mycobacterium ulcerans	pyruvate kinase	0.0036	0.033	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0165	0.0194
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0354	0.5947
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0026	0.0068
Onchocerca volvulus		0.0234	0.2841	1
Loa Loa (eye worm)	pyruvate kinase-PB	0.0025	0.0193	0.0495
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0257	0.3136	0.8096
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0908	0.234
Onchocerca volvulus		0.0016	0.0086	0.021
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0397	0.0468
Schistosoma mansoni	growth factor receptor-bound protein	0.0024	0.018	0.0205
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0627	0.2257
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0397	0.1021
Echinococcus multilocularis	GA binding protein alpha chain	0.0077	0.0852	0.085
Echinococcus multilocularis	pyruvate kinase	0.0028	0.0235	0.0233
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0037	0.0042
Brugia malayi	SH3 domain containing protein	0.0012	0.0026	0.0068
Schistosoma mansoni	pyruvate kinase	0.0018	0.0109	0.0121
Echinococcus granulosus	pyruvate kinase	0.0036	0.033	0.0389
Schistosoma mansoni	intermediate filament proteins	0.0026	0.021	0.024
Echinococcus multilocularis	c src tyrosine kinase	0.0031	0.0272	0.0271
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0012	0.003	0.0027
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.004	0.038	0.098
Schistosoma mansoni	hypothetical protein	0.0081	0.0908	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Echinococcus granulosus	tyrosine protein kinase HCK	0.0042	0.0415	0.049
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0194	0.2341	0.8224
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0011	0.0018	0.0016
Loa Loa (eye worm)	protein-tyrosine kinase	0.0012	0.0026	0.0064
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0024	0.018	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0327	0.084
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0191	0.2306	0.2728
Echinococcus granulosus	ETS transcription factor Elf 2	0.0011	0.0018	0.0019
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.2841	0.7971
Schistosoma mansoni	tyrosine kinase	0.018	0.2156	0.2545
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0154	0.1828	1
Loa Loa (eye worm)	thyroid receptor interactor	0.0012	0.0026	0.0064
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0012	0.003	0.0029
Echinococcus granulosus	tyrosine kinase	0.0055	0.0569	0.0672
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0012	0.003	0.0027
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0012	0.003	0.0029
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0189	0.2275	0.2686
Loa Loa (eye worm)	hypothetical protein	0.0066	0.071	0.183
Schistosoma mansoni	ap endonuclease	0.0038	0.0354	0.041
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0077
Echinococcus multilocularis	transfer RNA-Ala	0.0012	0.0026	0.0025
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.3237	0.9093
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0354	0.5947
Brugia malayi	Protein kinase domain containing protein	0.0291	0.3576	0.9232
Echinococcus granulosus	Spectrin alpha actinin	0.0012	0.0026	0.0029
Onchocerca volvulus		0.0012	0.003	0.0014
Onchocerca volvulus		0.0026	0.021	0.0652
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0026	0.0103
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0354	0.1902
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0012	0.0026	0.0029
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0191	0.2306	0.2305
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0327	0.084
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0327	0.0325
Schistosoma mansoni	tyrosine kinase	0.0066	0.0719	0.0843
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0154	0.1828	0.1827
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0627	0.1746
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0026	0.0068
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0012	0.003	0.0034
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0012	0.003	0.0034
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2082	0.582
Loa Loa (eye worm)	hypothetical protein	0.0175	0.2105	0.5432
Schistosoma mansoni	glutaminase	0.029	0.3558	0.4206
Schistosoma mansoni	hypothetical protein	0.004	0.0378	0.0439
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0354	0.5
Brugia malayi	Cytochrome P450 family protein	0.0048	0.048	0.1238
Schistosoma mansoni	tyrosine kinase	0.0019	0.0122	0.0136
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0066	0.0719	0.085
Brugia malayi	SH2 domain containing protein	0.0012	0.003	0.0078
Mycobacterium ulcerans	lipase LipD	0.0035	0.0327	0.0899
Echinococcus granulosus	pyruvate kinase	0.0018	0.0109	0.0128
Brugia malayi	MH2 domain containing protein	0.0116	0.1347	0.3479
Onchocerca volvulus		0.0019	0.0122	0.034
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0019	0.0122	0.0143
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0327	0.1162
Schistosoma mansoni	suppressor of cytokine signaling	0.0012	0.003	0.0027
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0194	0.2341	0.234
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0012	0.003	0.0034
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0012	0.003	0.0034
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.004	0.038	0.0448
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0154	0.1828	0.1827
Echinococcus granulosus	c src tyrosine kinase	0.0031	0.0272	0.032
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0064
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.004	0.038	0.1001
Schistosoma mansoni	serine/threonine protein kinase	0.016	0.1904	0.2247
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0154	0.1828	1
Trichomonas vaginalis	glutaminase, putative	0.029	0.3558	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0012	0.003	0.0078
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0012	0.003	0.0029
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0194	0.2341	0.277
Brugia malayi	RhoGAP domain containing protein	0.0012	0.003	0.0078
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2082	0.582
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0116	0.0595
Brugia malayi	Sex muscle abnormal protein 5	0.0024	0.018	0.0465
Echinococcus multilocularis	ets variant gene 4	0.0011	0.0018	0.0016
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0066	0.0719	0.0718
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0012	0.0028	0.0004
Brugia malayi	beta-lactamase	0.0035	0.0327	0.0843
Toxoplasma gondii	exonuclease III APE	0.0038	0.0354	0.5587
Echinococcus multilocularis	protein C ets 2	0.0011	0.0018	0.0016
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.22	0.6156
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.004	0.038	0.0441
Toxoplasma gondii	ABC1 family protein	0.0035	0.0327	0.5148
Brugia malayi	Src substrate cortactin	0.0012	0.0026	0.0068
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.004	0.038	1
Loa Loa (eye worm)	glutaminase 2	0.029	0.3558	0.9185
Echinococcus multilocularis	endophilin A3	0.0012	0.0026	0.0025
Schistosoma mansoni	lamin	0.0026	0.021	0.024
Schistosoma mansoni	gabp alpha	0.0077	0.0852	0.1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0189	0.2275	0.5873
Echinococcus multilocularis	Spectrin alpha actinin	0.0012	0.0026	0.0025
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0627	0.0734
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.004	0.038	0.1001
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0077
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1347	0.3476
Brugia malayi	Protein kinase domain containing protein	0.016	0.1904	0.4916
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0154	0.1828	0.1827
Leishmania major	pyruvate kinase	0.0036	0.033	0.1773
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0055	0.0569	0.0568
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0189	0.2275	0.2686
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0019	0.0122	0.09
Schistosoma mansoni	protein kinase	0.0196	0.2367	0.2796
Echinococcus multilocularis	tyrosine protein kinase shark	0.0019	0.0122	0.0121
Echinococcus granulosus	protein tyrosine kinase	0.0311	0.3827	0.4529
Echinococcus multilocularis	SHC transforming protein 3	0.0012	0.003	0.0029
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Brugia malayi	Fli-1 protein	0.0233	0.2837	0.7325
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0327	0.084
Brugia malayi	protein-tyrosine kinase	0.0012	0.0026	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0064
Echinococcus granulosus	NCK adaptor protein	0.0024	0.018	0.0212
Schistosoma mansoni	GTPase activating protein	0.0012	0.003	0.0027
Loa Loa (eye worm)	CMGC/CDK/CDK8 protein kinase	0.016	0.1904	0.4914
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0012	0.0026	0.0022
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2082	0.582
Brugia malayi	Guanylate kinase family protein	0.0014	0.0057	0.0148
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0011	0.0018	0.0019
Brugia malayi	hypothetical protein	0.0051	0.0521	0.1344
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.033	0.085
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0013	0.0047	0.0047
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.021	0.0542
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0627	1
Echinococcus granulosus	GA binding protein alpha chain	0.0077	0.0852	0.1006
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0066	0.0719	0.0718
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0327	0.0899
Echinococcus granulosus	expressed conserved protein	0.0012	0.003	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0122	0.0315
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Trypanosoma brucei	conserved protein	0.0012	0.0026	0.0103
Loa Loa (eye worm)	p53BP2	0.0012	0.0026	0.0064
Brugia malayi	SRC-1	0.0066	0.0719	0.1857
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0042	0.0415	0.0414
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0019	0.0122	0.0143
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0055	0.0138
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.038	0.2044
Onchocerca volvulus		0.0035	0.0327	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0193	0.0495
Onchocerca volvulus	Glucosylceramidase homolog	0.0174	0.2082	0.7301
Brugia malayi	Protein kinase domain containing protein	0.0194	0.2341	0.6045
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0116	0.0296
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0012	0.0026	0.0025
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0012	0.003	0.0034
Echinococcus multilocularis	tyrosine kinase	0.0019	0.0122	0.0121
Schistosoma mansoni	dreadlocks/dock	0.0012	0.0026	0.0022
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0081	0.0908	0.0906
Trichomonas vaginalis	esterase, putative	0.0035	0.0327	0.085
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.004	0.038	0.0441
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0257	0.0295
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0257	0.0295
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0354	0.0914
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.161	0.1609
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2082	0.582
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0354	0.1902
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0026	0.0103
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0011	0.0018	0.0016
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0354	0.5
Echinococcus multilocularis	pyruvate kinase	0.0018	0.0109	0.0108
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0521	0.2817
Loa Loa (eye worm)	hypothetical protein	0.025	0.3051	0.7876
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0327	0.085
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0397	0.1021
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0154	0.1828	1
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0026	0.0068
Schistosoma mansoni	serine/threonine protein kinase	0.0229	0.279	0.3297
Schistosoma mansoni	tensin-related	0.0012	0.003	0.0027
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.2341	0.2765
Echinococcus granulosus	cytochrome P450 2K1	0.001	0.0008	0.0007
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.004	0.038	0.3324
Chlamydia trachomatis	pyruvate kinase	0.0036	0.033	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2082	0.582
Echinococcus granulosus	protein C ets 2	0.0011	0.0018	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0308	0.0792
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0012	0.003	0.0029
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0055	0.0569	0.0672
Onchocerca volvulus		0.003	0.0257	0.0819
Toxoplasma gondii	pyruvate kinase PyKII	0.0018	0.0109	0.1642
Schistosoma mansoni	Dab2-interacting protein-like	0.0012	0.0026	0.0022
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0012	0.003	0.0029
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0521	0.2817
Onchocerca volvulus		0.0012	0.003	0.0014
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0327	0.0843
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0397	0.1049
Brugia malayi	Variant SH3 domain containing protein	0.0024	0.018	0.0465
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0081	0.0908	0.1073
Echinococcus granulosus	serine:threonine protein kinase TAO1	0.0229	0.279	0.3302
Echinococcus multilocularis	pyruvate kinase	0.0018	0.0109	0.0108
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0189	0.2275	0.2274
Onchocerca volvulus		0.0012	0.003	0.0014
Schistosoma mansoni	tensin	0.0012	0.003	0.0027
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.2341	0.6044
Echinococcus granulosus	ETS transcription factor Elf 2	0.0011	0.0018	0.0019
Loa Loa (eye worm)	SH2 domain-containing protein	0.0012	0.003	0.0074
Schistosoma mansoni	ets-related	0.0233	0.2837	0.3352
Brugia malayi	SH2 domain containing protein	0.0019	0.0122	0.0315
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0026	0.0103
Onchocerca volvulus		0.0012	0.003	0.0014
Schistosoma mansoni	sorting nexin	0.0012	0.0026	0.0022
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0031	0.0272	0.0271
Echinococcus granulosus	expressed protein	0.0012	0.0026	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0122	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0654	0.0766
Echinococcus multilocularis	MAM	0.0034	0.0308	0.0307
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0026	0.0068
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0122	0.0315
Schistosoma mansoni	cpg binding protein	0.003	0.0257	0.0296
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0012	0.003	0.0029
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0014	0.0058	0.0302
Echinococcus multilocularis	pyruvate kinase	0.0036	0.033	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Leishmania major	pyruvate kinase	0.0036	0.033	0.1773
Schistosoma mansoni	protein kinase	0.0196	0.2367	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0327	0.084
Loa Loa (eye worm)	hypothetical protein	0.0024	0.018	0.0462
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0012	0.003	0.0034
Echinococcus granulosus	expressed conserved protein	0.009	0.1016	0.1201
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0012	0.0026	0.0064
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0237	0.0607
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.0116	0.0305
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0036	0.033	0.0853
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Brugia malayi	CHE-14 protein	0.0041	0.0397	0.1025
Schistosoma mansoni	hypothetical protein	0.0011	0.0018	0.0012
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.033	0.108
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0327	0.9883
Echinococcus granulosus	ETS transcription factor Elf 5	0.0011	0.0018	0.0019
Echinococcus granulosus	pyruvate kinase	0.0036	0.033	0.0389
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0116	0.0296
Schistosoma mansoni	patched 1	0.0041	0.0397	0.0461
Trichomonas vaginalis	pyruvate kinase, putative	0.0036	0.033	0.0861
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0012	0.003	0.0074
Brugia malayi	intermediate filament protein	0.0026	0.021	0.0542
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0165	0.0164
Echinococcus multilocularis	signal transduction protein lnk realted	0.0012	0.003	0.0029
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0521	0.2817
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0627	0.3404
Schistosoma mansoni	hypothetical protein	0.0012	0.0026	0.0022
Schistosoma mansoni	tyrosine kinase	0.0066	0.0719	0.0843
Echinococcus granulosus	tyrosine protein kinase Blk	0.0055	0.0569	0.0672
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0327	0.1162
Brugia malayi	Ets-domain containing protein	0.0077	0.0852	0.2198
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.038	0.2044
Echinococcus multilocularis	pyruvate kinase	0.0018	0.0109	0.0108
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0066	0.0719	0.085
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0014	0.0051	0.0128
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0327	0.1752
Echinococcus granulosus	pyruvate kinase	0.0018	0.0109	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.038	0.1001
Schistosoma mansoni	tyrosine kinase	0.0031	0.0272	0.0313
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0265	0.3237	0.8358
Brugia malayi	beta-lactamase family protein	0.0035	0.0327	0.0843
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.2754	1
Brugia malayi	Tensin	0.0012	0.003	0.0078
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0012	0.0026	0.0022
Echinococcus multilocularis	expressed conserved protein	0.009	0.1016	0.1015
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Echinococcus granulosus	mitogen activated protein kinase 11	0.0154	0.1828	0.2163
Loa Loa (eye worm)	TK/ALK protein kinase	0.0291	0.3575	0.9229
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0354	0.0353
Schistosoma mansoni	pyruvate kinase	0.0036	0.033	0.0382
Schistosoma mansoni	hypothetical protein	0.0081	0.0908	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0018	0.0042
Schistosoma mansoni	tensin-related	0.0012	0.003	0.0027
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0189	0.2275	0.2692
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0019	0.0122	0.0121
Echinococcus granulosus	hypothetical protein	0.0012	0.003	0.0034
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0012	0.003	0.0027
Loa Loa (eye worm)	hypothetical protein	0.003	0.0257	0.066
Onchocerca volvulus		0.0034	0.0308	0.1001
Echinococcus granulosus	cpg binding protein	0.003	0.0257	0.0303
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0066	0.0719	0.0718
Brugia malayi	hypothetical protein	0.0012	0.003	0.0078
Echinococcus granulosus	intermediate filament protein	0.0026	0.021	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0026	0.021	0.0538
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0012	0.003	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0354	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0064
Leishmania major	hypothetical protein, conserved	0.0035	0.0327	0.1752
Entamoeba histolytica	protein kinase, putative	0.0042	0.0415	0.3658
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0066	0.0719	0.0718
Brugia malayi	Pre-SET motif family protein	0.003	0.0257	0.0663
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0116	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Brugia malayi	Ets-domain containing protein	0.0011	0.0018	0.0046
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.1108	0.1304
Schistosoma mansoni	growth factor receptor-bound protein	0.0024	0.018	0.0205
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0026	0.0068
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0257	0.3136	0.8096
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0154	0.1828	0.1827
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0196	0.2367	0.2366
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0327	0.0899
Schistosoma mansoni	SH2A	0.0012	0.003	0.0027
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0116	0.0595
Leishmania major	cytochrome p450-like protein	0.0019	0.0116	0.0595
Schistosoma mansoni	hypothetical protein	0.0675	0.8449	1
Schistosoma mansoni	hypothetical protein	0.0081	0.0908	0.1066
Brugia malayi	SH2 domain containing protein	0.0012	0.003	0.0078
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0066	0.0719	0.085
Loa Loa (eye worm)	hypothetical protein	0.005	0.0514	0.1324
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0037	0.0036
Plasmodium falciparum	pyruvate kinase	0.0036	0.033	0.5376
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0154	0.1828	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0327	0.0385
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0012	0.0026	0.0029
Echinococcus multilocularis		0.0012	0.003	0.0029
Echinococcus multilocularis	tensin	0.0012	0.003	0.0029
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0196	0.2367	0.2801
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0257	0.0255
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0627	0.0626
Schistosoma mansoni	formin binding protein and related proteins	0.0012	0.0026	0.0022
Echinococcus granulosus	SH2 motif	0.0012	0.003	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0327	0.084
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0122	0.0315
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0012	0.0026	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0037	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1089	0.281
Schistosoma mansoni	hypothetical protein	0.0011	0.0018	0.0012
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0257	0.4021
Schistosoma mansoni	hypothetical protein	0.0012	0.003	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0327	0.084
Schistosoma mansoni	suppressor of cytokine signaling	0.0012	0.003	0.0027
Schistosoma mansoni	nck2/grb4	0.0024	0.018	0.0205
Brugia malayi	hypothetical protein	0.0034	0.0308	0.0796
Schistosoma mansoni	tensin	0.0012	0.003	0.0027
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0354	0.1261
Echinococcus multilocularis	tensin	0.0012	0.003	0.0029
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0013	0.0047	0.0054
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0011	0.0018	0.0016
Schistosoma mansoni	cpg binding protein	0.0028	0.0237	0.0271
Schistosoma mansoni	run and tbc1 domain containing	0.0012	0.0026	0.0022
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0327	0.5284
Schistosoma mansoni	apoptosis stimulating of P53	0.0012	0.0026	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0272	0.0313
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0012	0.0026	0.0025
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0122	0.0311
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0055	0.0142
Brugia malayi	SH2 domain containing protein	0.0019	0.0122	0.0315
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0327	0.0378
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0012	0.0026	0.0029
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0154	0.1828	0.4719
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0237	0.0611
Brugia malayi	SH2 domain containing protein	0.0012	0.003	0.0078
Onchocerca volvulus		0.0019	0.0122	0.034
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0047	0.0477	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0415	0.1069
Schistosoma mansoni	hypothetical protein	0.0012	0.003	0.0027
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0026	0.0068
Schistosoma mansoni	cell polarity protein	0.0012	0.0026	0.0022
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0627	0.0741
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0327	0.9883
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.3237	0.9093
Echinococcus granulosus	N chimaerin	0.0012	0.003	0.0034
Brugia malayi	SH2 domain containing protein	0.0012	0.003	0.0078
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0012	0.0026	0.0022
Echinococcus granulosus	intersectin 2	0.0012	0.0026	0.0029
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0257	0.0295
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0011	0.0018	0.0016
Echinococcus multilocularis		0.001	0.0008	0.0006
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0055	0.0569	0.0568
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0354	0.1902
Loa Loa (eye worm)	cytochrome P450	0.001	0.0008	0.0016
Schistosoma mansoni	vav2	0.0014	0.0051	0.0052
Echinococcus granulosus	signal transduction protein lnk realted	0.0012	0.003	0.0034
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0327	0.1162
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0036	0.033	1
Brugia malayi	SH2 domain containing protein	0.0012	0.003	0.0078
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0354	0.9045
Echinococcus multilocularis	protein tyrosine kinase	0.0311	0.3827	0.3826
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0069	0.0747	0.0883
Loa Loa (eye worm)	SRC-1	0.0066	0.0719	0.1854
Echinococcus multilocularis	lamin	0.0026	0.021	0.0208
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0189	0.2275	0.5874
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0064
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0081	0.0908	0.1073
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0327	0.085
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0064
Echinococcus granulosus	MAM	0.0034	0.0308	0.0363
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0521	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.004	0.038	0.0448
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0569	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0308	0.0792
Echinococcus multilocularis	protein dispatched 1	0.0047	0.047	0.0469
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0012	0.0026	0.0064
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0031	0.0272	0.0313
Schistosoma mansoni	ap endonuclease	0.0038	0.0354	0.041
Schistosoma mansoni	sorbin	0.0012	0.0026	0.0022
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0627	0.1746
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0327	0.0899
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0308	0.0792
Loa Loa (eye worm)	STAT protein	0.0012	0.003	0.0074
Schistosoma mansoni	dynamin-associated protein	0.0012	0.0026	0.0022
Schistosoma mansoni	tyrosine kinase	0.0311	0.3827	0.4525
Schistosoma mansoni	hypothetical protein	0.0023	0.0165	0.0187
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.003	0.0078
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0011	0.0018	0.0016
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0122	0.0315
Echinococcus multilocularis	lamin dm0	0.0026	0.021	0.0208
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0194	0.2341	0.6045
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0024	0.018	0.0205
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0354	0.091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Onchocerca volvulus		0.0026	0.021	0.0652
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0354	0.0928
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0036	0.033	0.1773
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0012	0.0026	0.0025
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0189	0.2275	0.2274
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0257	0.0295
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0327	0.1162
Loa Loa (eye worm)	TK/FAK protein kinase	0.0315	0.3873	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2082	0.582
Entamoeba histolytica	pyruvate kinase, putative	0.0025	0.0193	0.1568
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0327	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0064
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0012	0.0026	0.0068
Echinococcus granulosus	src region	0.0012	0.0026	0.0029
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0327	0.0378
Echinococcus granulosus	tyrosine protein kinase shark	0.0019	0.0122	0.0143
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0066	0.0719	0.085
Loa Loa (eye worm)	SH2 domain-containing protein	0.0012	0.003	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0257	0.3136	0.8096
Echinococcus multilocularis	SH2 motif	0.0012	0.003	0.0029
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0116	0.0299
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.3237	0.9093
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0012	0.0026	0.0029
Echinococcus granulosus	pyruvate kinase	0.0018	0.0109	0.0128
Brugia malayi	beta-lactamase family protein	0.0035	0.0327	0.0843
Brugia malayi	protein-tyrosine kinase	0.0055	0.0569	0.1469
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0521	0.1341
Giardia lamblia	Pyruvate kinase	0.0036	0.033	0.8176
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.021	0.0538
Onchocerca volvulus		0.0019	0.0122	0.034
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.004	0.038	0.2044
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0327	0.085
Onchocerca volvulus		0.0012	0.003	0.0014
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.1089	0.2813
Trichomonas vaginalis	pyruvate kinase, putative	0.0036	0.033	0.0861
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0354	0.1902
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0521	1
Schistosoma mansoni	lamin	0.0026	0.021	0.024
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.1089	0.1088
Echinococcus multilocularis	N chimaerin	0.0012	0.003	0.0029
Echinococcus granulosus	SH2 domain containing protein 7	0.0012	0.003	0.0034
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0066	0.0719	0.085
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0327	0.1752
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0036	0.033	0.0853
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0013	0.0047	0.0046
Echinococcus granulosus	ewsr:fli fusion protein type	0.0011	0.0018	0.0019
Echinococcus multilocularis	GPCR, family 2	0.0081	0.0908	0.0906
Entamoeba histolytica	protein kinase, putative	0.0014	0.0058	0.0302
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0354	0.0417
Brugia malayi	Tyrosine-protein kinase abl-1	0.0031	0.0272	0.0702
Echinococcus granulosus	tensin	0.0012	0.003	0.0034
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0012	0.0026	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0036	0.033	0.085
Echinococcus multilocularis	serine:threonine protein kinase TAO1	0.0229	0.279	0.2789
Onchocerca volvulus		0.0012	0.003	0.0014
Schistosoma mansoni	hypothetical protein	0.0034	0.0308	0.0356
Echinococcus granulosus	geminin	0.0675	0.8449	1
Echinococcus granulosus	SHC transforming protein 3	0.0012	0.003	0.0034
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0327	0.0899
Schistosoma mansoni	hypothetical protein	0.004	0.0378	0.0439
Schistosoma mansoni	signal transduction protein lnk-related	0.0012	0.003	0.0027
Echinococcus multilocularis	geminin	0.0675	0.8449	0.8449
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0573	0.9116
Onchocerca volvulus		0.0019	0.0122	0.034
Schistosoma mansoni	ets	0.0011	0.0018	0.0012
Brugia malayi	DNA-binding protein D-ETS-3	0.0011	0.0018	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0028	0.0068
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0354	0.3081
Entamoeba histolytica	SH2 domain containing protein	0.0012	0.003	0.0036
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0354	0.0975
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0066	0.0719	0.085
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0012	0.003	0.0078
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0024	0.018	0.0462
Echinococcus multilocularis	intersectin 2	0.0012	0.0026	0.0025
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0066	0.0719	0.0718
Plasmodium vivax	pyruvate kinase, putative	0.0036	0.033	0.5376
Schistosoma mansoni	hypothetical protein	0.0034	0.0308	0.0356
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.3237	0.9093
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0074
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0011	0.0018	0.0042
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0066	0.0719	0.0718
Schistosoma mansoni	tensin	0.0012	0.003	0.0027
Schistosoma mansoni	ets-related	0.0011	0.0018	0.0012
Brugia malayi	Ets-domain containing protein	0.0077	0.0852	0.2198
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0012	0.003	0.0029
Schistosoma mansoni	C-fyn	0.0012	0.0026	0.0022
Loa Loa (eye worm)	ets-domain-containing protein	0.0011	0.0018	0.0042
Echinococcus multilocularis	SH2 domain containing protein 7	0.0012	0.003	0.0029
Brugia malayi	hypothetical protein	0.0033	0.0292	0.0754
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0257	0.3136	0.8096
Schistosoma mansoni	hypothetical protein	0.004	0.0378	0.0439
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0081	0.0908	0.0906
Schistosoma mansoni	adapter molecule crk	0.0024	0.018	0.0205
Echinococcus granulosus	endophilin A3	0.0012	0.0026	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0051	0.0128
Echinococcus multilocularis	cpg binding protein	0.003	0.0257	0.0256
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0327	0.085
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.22	0.6156
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0012	0.0026	0.0025
Brugia malayi	SH2 domain containing protein	0.0012	0.003	0.0078
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0257	0.0302
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.033	0.108
Echinococcus granulosus	ubiquitin specific protease 41	0.004	0.038	0.0448
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0012	0.0026	0.0029
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0036	0.033	0.1176
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0047	0.0477	0.0476
Brugia malayi	Serine/threonine-protein kinase SULU	0.0229	0.279	0.7205
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.033	0.108
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0018	0.0042
Brugia malayi	P38 map kinase family protein 2	0.0154	0.1828	0.4721
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.2482	0.6408
Brugia malayi	Myosin tail family protein	0.0012	0.0026	0.0068
Brugia malayi	latrophilin 2 splice variant baaae	0.0175	0.2105	0.5433
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0189	0.2275	0.2692
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1347	0.3476
Echinococcus granulosus	mitogen activated protein kinase 14	0.0154	0.1828	0.2163
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0627	0.1746
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0036	0.033	0.1773
Schistosoma mansoni	eps8-related protein	0.0012	0.0026	0.0022
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0011	0.0018	0.0042
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.004	0.038	0.0378
Schistosoma mansoni	hypothetical protein	0.004	0.0378	0.0439
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0122	0.0315
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.004	0.038	0.0378
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0011	0.0018	0.0012
Brugia malayi	cytochrome P450	0.001	0.0008	0.002
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0077	0.0852	0.2196
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0081	0.0908	0.2343
Trypanosoma brucei	pyruvate kinase 1	0.0036	0.033	0.1773
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0235	0.0277
Brugia malayi	Cytochrome P450 family protein	0.001	0.0008	0.002
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0116	0.0595
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.1089	1
Echinococcus multilocularis	SH2 motif	0.0012	0.003	0.0029
Schistosoma mansoni	hypothetical protein	0.0012	0.0026	0.0022
Brugia malayi	Variant SH3 domain containing protein	0.0014	0.0051	0.0132
Brugia malayi	glutaminase DH11.1	0.029	0.3558	0.9186
Loa Loa (eye worm)	fli-1 protein	0.0233	0.2837	0.7324

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ALK	ChEMBL.	No reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LCK	ChEMBL.	No reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TAO1	ChEMBL.	No reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PTK2	ChEMBL.	No reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: BTK	ChEMBL.	No reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1	ChEMBL.	No reference
Ki (functional)	> 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FYN	ChEMBL.	No reference
Ki (functional)	= 5.8	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK8	ChEMBL.	No reference
Ki (functional)	= 6.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPK14	ChEMBL.	No reference
Ki (functional)	= 6.3	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LIMK1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2006149

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1649386