TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.479 | Formula: C20H13N5O3S2
H donors: 1 H acceptors: 6 LogP: 2.96 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cc(ccc1Oc1ccccc1c1cncnc1)S(=O)(=O)Nc1nccs1
InChi: 1S/C20H13N5O3S2/c21-10-14-9-16(30(26,27)25-20-24-7-8-29-20)5-6-18(14)28-19-4-2-1-3-17(19)15-11-22-13-23-12-15/h1-9,11-13H,(H,24,25)
InChiKey: MLYRCRIJAXPEOA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sodium channel, voltage-gated, type IX, alpha subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania infantum	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania braziliensis	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania major	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania donovani	calcium channel protein, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania mexicana	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	orexin receptor type 2	0.0054	0.0116	0.0116
Schistosoma mansoni	amine GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.001	0.0011	0.0012
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.001	0.0012	0.0012
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0049	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	RUN	0.0019	0.0034	0.0034
Echinococcus granulosus	vesicular acetylcholine transporter	0.2319	0.5485	0.5504
Brugia malayi	G-protein coupled receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0165	0.0378	0.0379
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0009	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Brugia malayi	Cytochrome P450 family protein	0.001	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0011
Echinococcus granulosus	sodium and chloride dependent glycine	0.0715	0.1681	0.1687
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0008	0.0008
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0054	0.0116	0.0116
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.001	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.001	0.0012	0.1393
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0003	0.00000000081715
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0031	0.0031
Schistosoma mansoni	ap endonuclease	0.0018	0.0031	0.0031
Onchocerca volvulus		0.0054	0.0116	0.0116
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0048	0.0102	0.0102
Schistosoma mansoni	vesicular amine transporter	0.0007	0.0005	0.0005
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.001	0.0012	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0034	0.0034
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0011	0.0012
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0105	1
Schistosoma mansoni	DNA helicase recq5	0.0009	0.0008	0.0008
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0008	0.0008
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0054	0.0116	0.0116
Schistosoma mansoni	lipoxygenase	0.0081	0.018	0.018
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0054	0.0116	0.0116
Brugia malayi	sulfakinin receptor protein	0.0054	0.0116	0.0116
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0054	0.0116	0.0116
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.001	0.0012	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0116	0.0116
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0054	0.0116	0.0116
Plasmodium falciparum	transporter, putative	0.0715	0.1681	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0116	0.0116
Echinococcus multilocularis	transient receptor potential cation channel	0.0005	0.0001	0.0001
Brugia malayi	follicle stimulating hormone receptor	0.0054	0.0116	0.0116
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0715	0.1681	1
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0116	0.0116
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0003	0.00000000081715
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0012	0.0012
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.001	0.0011	0.0011
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0008	0.0008
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0116	0.0116
Brugia malayi	Dopamine receptor	0.0054	0.0116	0.0116
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.001	0.0012	0.1213
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0715	0.1681	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0009	0.0008	0.0008
Brugia malayi	Serotonin receptor	0.0054	0.0116	0.0116
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.001	0.0012	0.1213
Echinococcus multilocularis	serotonin receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.001	0.0011	0.0012
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0715	0.1681	0.1687
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0715	0.1681	0.1687
Schistosoma mansoni	opsin-like receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0116	0.0116
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0008	0.0048
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	sodium/chloride dependent transporter	0.0715	0.1682	0.1688
Brugia malayi	Cyclic-nucleotide gated cation channel	0.001	0.0011	0.0011
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0014	0.0014
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0113	0.0672
Schistosoma mansoni	amine GPCR	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Schistosoma mansoni	hypothetical protein	0.0014	0.0021	0.0021
Treponema pallidum	sodium- and chloride- dependent transporter	0.4209	0.9965	1
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus granulosus	sodium channel protein	0.0048	0.0101	0.0101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0021	0.0021
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0715	0.1681	1
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.001	0.0012	0.1213
Brugia malayi	Serotonin receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0037	0.0037
Echinococcus granulosus	short transient receptor potential channel 6	0.0005	0.0001	0.0001
Brugia malayi	RE15519p	0.0054	0.0116	0.0116
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0054	0.0116	0.0116
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0715	0.1681	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0031	0.0031
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0034	0.0034
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0003	0.00000000081715
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.0157	0.0158
Brugia malayi	Dopamine receptor protein 1	0.0054	0.0116	0.0116
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.4209	0.9965	1
Echinococcus granulosus	RUN	0.0019	0.0034	0.0034
Trichomonas vaginalis	ferritin, putative	0.0008	0.0007	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Leishmania major	cytochrome p450-like protein	0.001	0.0012	0.0012
Echinococcus granulosus	hypothetical protein	0.0054	0.0116	0.0116
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.001	0.0012	0.1213
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.001	0.0011	0.0011
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0031	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0715	0.1681	0.1681
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.001	0.0012	0.1393
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0116	0.0116
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.001	0.0012	0.1213
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	hypothetical protein	0.0054	0.0116	0.0116
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0014	0.0014
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0715	0.1681	0.1681
Schistosoma mansoni	vesicular acetylcholine transporter	0.2319	0.5485	0.5504
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.0001
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0116	0.0116
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0048	0.0101	0.0101
Schistosoma mansoni	apoferritin-2	0.0008	0.0007	0.0007
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0101	0.0101
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.001	0.0012	0.1213
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.001	0.0012	0.1393
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	amine GPCR	0.0054	0.0116	0.0116
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.2159	0.5105	0.5105
Echinococcus granulosus	fmrfamide receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	hyperpolarization activated cyclic	0.001	0.0011	0.0012
Schistosoma mansoni	hypothetical protein	0.0165	0.0378	0.0379
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0021	0.0021
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.001	0.0011	0.0857
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0021	0.0021
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0021	0.0021
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0054	0.0116	0.0116
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.001	0.0012	0.1393
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0074	0.0074
Brugia malayi	Doublecortin family protein	0.0019	0.0034	0.0034
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0037	0.3337
Echinococcus granulosus	neuropeptide receptor A26	0.0501	0.1175	0.1179
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0031	0.0031
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0054	0.0116	0.0116
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0074	0.0073
Brugia malayi	ORL1-like opioid receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	mitogen activated protein kinase 3	0.0049	0.0105	0.0105
Onchocerca volvulus		0.0054	0.0116	0.0116
Echinococcus multilocularis	hyperpolarization activated cyclic	0.001	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0715	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.008	0.008
Brugia malayi	neuropeptide F receptor	0.0054	0.0116	0.0116
Brugia malayi	Cytochrome P450 family protein	0.001	0.0012	0.0012
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0049	0.0105	0.0105
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.001	0.0012	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	sex peptide receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	TYRA-2 protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	Ankyrin	0.0014	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Brugia malayi	putative neuropeptide receptor NPR1	0.0054	0.0116	0.0116
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0074	0.0073
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0116	0.0116
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.001	0.0012	0.1393
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	DNA helicase recq1	0.0009	0.0008	0.0008
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0031	0.0031
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.001	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0068	0.0068
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.001	0.0012	0.1213
Echinococcus granulosus	7TM GPCR rhodopsin	0.0054	0.0116	0.0116
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.001	0.0012	0.0012
Brugia malayi	Melatonin receptor type 1A	0.0054	0.0116	0.0116
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0022	0.0022
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0067	0.6289
Brugia malayi	hypothetical protein	0.0019	0.0034	0.0034
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0715	0.1681	0.1681
Brugia malayi	AKH receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	dro:myosuppressin receptor	0.0054	0.0116	0.0116
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0074	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0715	0.1681	0.1681
Onchocerca volvulus		0.0054	0.0116	0.0116
Echinococcus granulosus	ferritin	0.0008	0.0007	0.0007
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0003	0.00000000081715
Schistosoma mansoni	opsin-like receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.001	0.0011	0.0012
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0054	0.0116	0.0116
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.2319	0.5485	0.5485
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus granulosus	G protein coupled receptor 139	0.0054	0.0116	0.0116
Schistosoma mansoni	histamine h1 receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0102	0.0102
Schistosoma mansoni	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0028	0.0054	0.0054
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0715	0.1681	0.1681
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0715	0.1681	0.1687
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0014	0.0014
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.001	0.0012	0.1213
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0054	0.0116	0.0116
Schistosoma mansoni	cytochrome P450	0.001	0.0012	0.0012
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0128	0.0128
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0065	1
Brugia malayi	G-protein coupled receptor	0.0054	0.0116	0.0116
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0037	0.0037
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0009	0.0008	0.0008
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0031	0.0031
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.001	0.0012	0.1393
Echinococcus multilocularis	orexin receptor type 2	0.0054	0.0116	0.0116
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.4209	0.9965	0.9965
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0004	0.0004
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0049	0.0105	0.0105
Schistosoma mansoni	ferritin light chain	0.0008	0.0007	0.0007
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0054	0.0116	0.0116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0116	0.0116
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0116	0.0116
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	somatostatin receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.001	0.0011	0.0012
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0021	0.0021
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0054	0.0054
Echinococcus granulosus	dro:myosuppressin receptor	0.0054	0.0116	0.0116
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0034	0.02
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0116	0.0116
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.001	0.0012	0.1213
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0003	0.00000000081715
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0715	0.1681	0.1687
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0019	0.0019
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0031	0.2372
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0116	0.0116
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus granulosus	tumor protein p63	0.0328	0.0766	0.0768
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.001	0.0012	0.1213
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.001	0.0012	0.1213
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0031	0.0031
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0034	0.0034
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0074	0.6937
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0074	0.6937
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Schistosoma mansoni	growth hormone secretagogue receptor	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0054	0.0116	0.0116
Schistosoma mansoni	ferritin light chain	0.0008	0.0007	0.0007
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0715	0.1681	0.1687
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.001	0.0012	0.1393
Schistosoma mansoni	polycystin 1-related	0.0019	0.0034	0.0034
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0074	0.0074
Schistosoma mansoni	sodium/chloride dependent transporter	0.0715	0.1681	0.1687
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0054	0.0116	0.0116
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0715	0.1681	0.1687
Loa Loa (eye worm)	hypothetical protein	0.0715	0.1681	0.1681
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0003	0.00000000081715
Schistosoma mansoni	loxhd1	0.0019	0.0034	0.0034
Onchocerca volvulus		0.0054	0.0116	0.0116
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0715	0.1681	0.1681
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.0008
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0008	0.0007	0.0538
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0715	0.1681	0.1687
Onchocerca volvulus		0.0019	0.0034	0.0033
Loa Loa (eye worm)	solute carrier family 6 member 4	0.4209	0.9965	0.9965
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Schistosoma mansoni	myosin xvIII	0.0054	0.0116	0.0116
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0715	0.1681	0.1687
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0021	0.0021
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0048	0.0101	0.0101
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0116	0.0262	0.0263
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0037	0.0037
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.001	0.0012	0.1213
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0054	0.0116	0.0116
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0116	0.0116
Brugia malayi	GnHR receptor homolog	0.0054	0.0116	0.0116
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0116	0.0116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0116	0.0116
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	calcium activated potassium channel	0.0006	0.0001	0.0001
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.0105	0.0105
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0049	0.0105	0.0105
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0116	0.0116
Trypanosoma cruzi	cytochrome P450, putative	0.001	0.0012	0.0012
Echinococcus multilocularis	geminin	0.0165	0.0378	0.0379
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0715	0.1681	0.1687
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0031	0.3879
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0031	0.0031
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0116	0.0116
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0009	0.0008	0.0008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus granulosus	sex peptide receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	G protein coupled receptor 139	0.0054	0.0116	0.0116
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0074	1
Schistosoma mansoni	hypothetical protein	0.001	0.0012	0.0012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.001	0.0011	0.0012
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0003	0.00000000081715
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	ferritin	0.0008	0.0007	0.0007
Trypanosoma cruzi	cytochrome P450, putative	0.001	0.0012	0.0012
Plasmodium vivax	hypothetical protein, conserved	0.0715	0.1681	1
Echinococcus granulosus	cytochrome P450 2K1	0.001	0.0012	0.0012
Leishmania major	cytochrome p450-like protein	0.001	0.0012	0.0012
Echinococcus granulosus	neuropeptide FF receptor 2	0.0054	0.0116	0.0116
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0019	0.0019
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Echinococcus multilocularis	dnaJ subfamily B	0.0397	0.0929	0.0933
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0031	0.2855
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	allatostatin A receptor	0.0054	0.0116	0.0116
Brugia malayi	vesicular acetylcholine transporter unc-17	0.2319	0.5485	0.5485
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	serotonin receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0054	0.0116	0.0116
Schistosoma mansoni	hypothetical protein	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.001	0.0012	0.1213
Onchocerca volvulus		0.0054	0.0116	0.0116
Schistosoma mansoni	hypothetical protein	0.0397	0.0929	0.0933
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.001	0.0012	0.1213
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0049	0.0105	0.0105
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.001	0.0012	0.1213
Echinococcus multilocularis	sodium channel protein	0.0048	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0102	0.0102
Echinococcus multilocularis	ferritin	0.0008	0.0007	0.0007
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.001	0.0012	0.1213
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0034	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.008	0.008
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0116	0.0116
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.001	0.0012	0.1393
Schistosoma mansoni	amine GPCR	0.0054	0.0116	0.0116
Mycobacterium ulcerans	bacterioferritin BfrB	0.0008	0.0007	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	ferritin	0.0008	0.0007	0.0007
Schistosoma mansoni	adenoreceptor	0.0054	0.0116	0.0116
Brugia malayi	G protein-coupled receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	cpg binding protein	0.0029	0.0058	0.0058
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.001	0.0012	0.1393
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0004	0.0004
Schistosoma mansoni	ap endonuclease	0.0018	0.0031	0.0031
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0034	0.0034
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0116	0.0116
Echinococcus multilocularis	serotonin transporter	0.4209	0.9965	1
Echinococcus multilocularis	tumor protein p63	0.0328	0.0766	0.0768
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.001	0.0011	0.0012
Echinococcus multilocularis	g-protein coupled receptor	0.0054	0.0116	0.0116
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.001	0.0012	0.0012
Schistosoma mansoni	cpg binding protein	0.0029	0.0058	0.0058
Schistosoma mansoni	cpg binding protein	0.0029	0.0058	0.0058
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.001	0.0012	0.1213
Onchocerca volvulus		0.0715	0.1681	0.1687
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0049	0.0105	0.0105
Onchocerca volvulus		0.0715	0.1681	0.1687
Loa Loa (eye worm)	serotonin transporter b	0.4209	0.9965	0.9965
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.001	0.0011	0.0012
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0105	1
Onchocerca volvulus		0.0054	0.0116	0.0116
Brugia malayi	MAP kinase sur-1	0.0049	0.0105	0.0105
Echinococcus granulosus	serotonin transporter	0.4209	0.9965	1
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.001	0.0012	0.1393
Leishmania major	cytochrome p450-like protein	0.001	0.0012	0.0012
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0054	0.0116	0.0116
Brugia malayi	cytochrome P450	0.001	0.0012	0.0012
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0715	0.1681	0.1687
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0054	0.0116	0.0116
Trypanosoma brucei	protein kinase, putative	0.0049	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.4209	0.9965	0.9965
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	cpg binding protein	0.0029	0.0058	0.0058
Schistosoma mansoni	60S ribosomal protein L21	0.0009	0.0008	0.0008
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0116	0.0116
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0018	0.0031	0.0184
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0116	0.0116
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0715	0.1681	0.1687
Schistosoma mansoni	apoferritin-2	0.0008	0.0007	0.0007
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0087	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0019	0.0019
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0031	0.0031
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0116	0.0116
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0009	0.0008	0.0048
Plasmodium falciparum	amino acid transporter, putative	0.0715	0.1681	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0054	0.0116	0.0116
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0074	0.0074
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0715	0.1681	0.1687
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.001	0.0012	0.1213
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0715	0.1681	0.1681
Schistosoma mansoni	cpg binding protein	0.0028	0.0054	0.0054
Echinococcus multilocularis	expressed protein	0.0008	0.0007	0.0007
Schistosoma mansoni	ferritin	0.0008	0.0007	0.0007
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0034	0.0034
Schistosoma mansoni	transient receptor potential channel	0.0005	0.0001	0.0001
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.001	0.0012	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0027
Echinococcus granulosus	calcium activated potassium channel	0.0006	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.4209	0.9965	0.9965
Echinococcus granulosus	g-protein coupled receptor	0.0054	0.0116	0.0116
Trichomonas vaginalis	DNA helicase recq, putative	0.0011	0.0014	0.1101
Brugia malayi	neuropeptide F receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	neuropeptide receptor A26	0.0501	0.1175	0.1179
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Onchocerca volvulus		0.4209	0.9965	1
Echinococcus granulosus	expressed protein	0.0008	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Brugia malayi	larval opioid receptor	0.0054	0.0116	0.0116
Brugia malayi	hypothetical protein	0.0019	0.0034	0.0034
Echinococcus multilocularis	short transient receptor potential channel 6	0.0005	0.0001	0.0001
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0715	0.1681	0.1687
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Schistosoma mansoni	ferritin	0.0008	0.0007	0.0007
Brugia malayi	Cytochrome P450 family protein	0.001	0.0012	0.0012
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0031	0.2767
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0019	0.0019
Giardia lamblia	Kinase, CMGC MAPK	0.0049	0.0105	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0715	0.1681	0.1681
Loa Loa (eye worm)	cytochrome P450	0.001	0.0012	0.0012
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0034	0.0034
Schistosoma mansoni	lipoxygenase	0.0116	0.0262	0.0263
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.001	0.0011	0.0857
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0715	0.1681	0.1687
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0715	0.1681	0.1687
Echinococcus granulosus	death domain containing protein	0.0014	0.0021	0.0021
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.001	0.0011	0.0012
Schistosoma mansoni	rab6-interacting	0.0019	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0087	0.0088
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.001	0.0012	0.1213
Loa Loa (eye worm)	hypothetical protein	0.4209	0.9965	0.9965
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.001	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0019	0.0019
Echinococcus multilocularis	serotonin receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0054	0.0116	0.0116
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0037	0.0037
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0116	0.0116
Schistosoma mansoni	hypothetical protein	0.0019	0.0034	0.0034
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0074	0.0074
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0116	0.0116
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.001	0.0012	0.1393
Mycobacterium ulcerans	bacterioferritin BfrA	0.0008	0.0007	0.0468
Schistosoma mansoni	neuropeptide f receptor 76f	0.0054	0.0116	0.0116
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0074	0.6937
Brugia malayi	G protein-coupled receptor F59B2.13	0.0054	0.0116	0.0116
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0034	0.0034
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0054	0.0116	0.0116
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0021	0.0021
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0019	0.0019
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.001	0.0012	0.1213
Schistosoma mansoni	sodium/chloride dependent transporter	0.4209	0.9965	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0074	0.0074
Brugia malayi	hypothetical protein	0.0715	0.1681	0.1681
Echinococcus granulosus	allatostatin A receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0019	0.0019
Echinococcus granulosus	Ankyrin	0.0014	0.0021	0.0021
Echinococcus multilocularis	transient receptor potential cation channel	0.0005	0.0001	0.0001
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.0157	0.0158
Onchocerca volvulus		0.0054	0.0116	0.0116
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0116	0.0116
Brugia malayi	Inositol-1	0.0036	0.0074	0.0074
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.001	0.0012	0.1393
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0021	0.0021
Echinococcus granulosus	dnaJ subfamily B	0.0397	0.0929	0.0933
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0031	0.3579
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.008	0.008
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0067	0.6289
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.001	0.0011	0.0012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0116	0.0116
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0715	0.1681	0.1681
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0116	0.0116
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0715	0.1681	0.1687
Schistosoma mansoni	blooms syndrome DNA helicase	0.0016	0.0027	0.0027
Mycobacterium leprae	Conserved hypothetical protein	0.001	0.0012	0.0904
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0715	0.1681	0.1687
Trypanosoma brucei	cytochrome P450, putative	0.001	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0031	0.4455
Toxoplasma gondii	hypothetical protein	0.0715	0.1681	1
Onchocerca volvulus		0.0054	0.0116	0.0116
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0116	0.0262	0.0263
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0008	0.0048
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0021	0.0021
Schistosoma mansoni	amine GPCR	0.0054	0.0116	0.0116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Plasmodium vivax	amine transporter, putative	0.0715	0.1681	1
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0116	0.0116
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.001	0.0012	0.0012
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0054	0.0116	0.0116
Brugia malayi	hypothetical protein	0.0054	0.0116	0.0116
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0074	0.0073
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0009	0.0008	0.0008
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0101	0.0101
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0049	0.0105	0.0105
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.2319	0.5485	0.5504
Echinococcus multilocularis	vesicular acetylcholine transporter	0.2319	0.5485	0.5504
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0054	0.0116	0.0116
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.0021	0.0122
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0054	0.0116	0.0116
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0054	0.0116	0.0116
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0054	0.0116	0.0116
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0054	0.0116	0.0116
Brugia malayi	Death domain containing protein	0.0014	0.0021	0.0021
Echinococcus multilocularis	mitogen activated protein kinase	0.0049	0.0105	0.0105
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.001	0.0012	0.1393
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0105	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0054	0.0116	0.0116
Toxoplasma gondii	hypothetical protein	0.0715	0.1681	1
Brugia malayi	putative neuropeptide receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0034	0.0034
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.001	0.0012	0.1213
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0065	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Schistosoma mansoni	rab6-interacting	0.0019	0.0034	0.0034
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0037	0.3337
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0021	0.0021
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0004	0.0004
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.0008
Brugia malayi	olfactory channel protein osm-9	0.0005	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0054	0.0116	0.0116
Onchocerca volvulus		0.0054	0.0116	0.0116
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0116	0.0116
Echinococcus multilocularis	somatostatin receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Toxoplasma gondii	exonuclease III APE	0.0018	0.0031	0.0184
Loa Loa (eye worm)	norepinephrine transporter	0.4209	0.9965	0.9965
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0031	0.0184
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0074	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0019	0.0019
Brugia malayi	Uncoordinated protein 44	0.0014	0.0021	0.0021
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	mitogen activated protein kinase	0.0049	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.001	0.0012	0.1393
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0039	0.008	0.008
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0049	0.0105	0.0625
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0105	0.0105
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0116	0.0116
Loa Loa (eye worm)	CYP4Cod1	0.001	0.0012	0.0012
Echinococcus granulosus	neuropeptide s receptor	0.0501	0.1175	0.1179
Echinococcus multilocularis	hyperpolarization activated cyclic	0.001	0.0011	0.0012
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.001	0.0012	0.1393
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0003	0.00000000081715
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0034	0.0034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0116	0.0116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0116	0.0116
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0715	0.1681	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis		0.001	0.0012	0.0012
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	hyperpolarization activated cyclic	0.001	0.0011	0.0012
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0009	0.0008	0.0008
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.0105	0.0105
Echinococcus granulosus	transient receptor potential cation channel	0.0005	0.0001	0.0001
Echinococcus granulosus	geminin	0.0165	0.0378	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Brugia malayi	Dopamine receptor protein 2	0.0054	0.0116	0.0116
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0004	0.0004
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0715	0.1681	0.1687
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0054	0.0116	0.0116
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0074	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0054	0.0116	0.0116
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0031	0.0024
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0715	0.1681	0.1681
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0008	0.0008
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0008	0.0007	0.0538
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Onchocerca volvulus		0.0054	0.0116	0.0116
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0116	0.0116
Echinococcus granulosus	7tm_1 domain containing protein	0.0054	0.0116	0.0116
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0031	0.2767
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0054	0.0116	0.0116
Mycobacterium leprae	putative cytochrome p450	0.001	0.0012	0.0904
Echinococcus granulosus	sodium and chloride dependent glycine	0.0715	0.1681	0.1687
Schistosoma mansoni	hypothetical protein	0.0054	0.0116	0.0116
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0116	0.0116
Schistosoma mansoni	opsin-like receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0012	0.0012
Toxoplasma gondii	cytochrome p450 superfamily protein	0.001	0.0012	0.0074
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.001	0.0011	0.0012
Echinococcus multilocularis	neuropeptide s receptor	0.0501	0.1175	0.1179
Onchocerca volvulus		0.0019	0.0034	0.0033
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.001	0.0012	0.1393
Loa Loa (eye worm)	inositol-1	0.0036	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0116	0.0116
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0105	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0715	0.1681	0.1687
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0008	0.0008
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0054	0.0116	0.0116
Loa Loa (eye worm)	melatonin receptor type 1A	0.0054	0.0116	0.0116

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.6383	Inhibition of NaV1.7 ion channel (unknown origin)	ChEMBL.	23177785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2326132

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1728086