Detailed information for compound 1994846

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 570.689 | Formula: C30H38N10O2
  • H donors: 3 H acceptors: 6 LogP: 3.83 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(cc1Nc1ncnc2c1nc(nc2)N1CCN(CC1)CC1COCC1)C(=O)Nc1[nH]nc(c1)C(C)(C)C
  • InChi: 1S/C30H38N10O2/c1-19-5-6-21(28(41)35-25-14-24(37-38-25)30(2,3)4)13-22(19)34-27-26-23(32-18-33-27)15-31-29(36-26)40-10-8-39(9-11-40)16-20-7-12-42-17-20/h5-6,13-15,18,20H,7-12,16-17H2,1-4H3,(H,32,33,34)(H2,35,37,38,41)
  • InChiKey: LOGKCJOGTUENSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens B-Raf proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus protein kinase 0.0121 0.0929 0.0891
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0063 0.017 0.0128
Loa Loa (eye worm) hypothetical protein 0.0242 0.2536 0.2761
Schistosoma mansoni protein kinase C mu 0.0181 0.1724 0.336
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0094 0.057 0.1795
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.057 0.1723
Echinococcus multilocularis casein kinase I delta 0.0085 0.0464 0.0565
Giardia lamblia Kinase, NEK 0.0107 0.0751 0.2834
Giardia lamblia Kinase, NEK 0.0107 0.0751 0.2834
Loa Loa (eye worm) AGC/AKT protein kinase 0.0237 0.2471 0.269
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0065 0.0196 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0735 0.1432
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0066 0.0205 0.0399
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0311 0.3451 0.3758
Loa Loa (eye worm) thyroid receptor interactor 0.0092 0.0556 0.0604
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0125 0.0992 0.3549
Brugia malayi SRC-1 0.0185 0.1787 0.1913
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0781 0.316
Plasmodium vivax unspecified product 0.0079 0.0374 0.2526
Brugia malayi Protein kinase domain containing protein 0.0171 0.1597 0.1705
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0183 0.1758 0.1723
Entamoeba histolytica protein kinase, putative 0.0064 0.0179 0.0542
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0179 0.035
Echinococcus granulosus tyrosine protein kinase Srms 0.0406 0.4702 0.4679
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0132 0.1084 0.1322
Trypanosoma cruzi casein kinase, putative 0.0085 0.0464 0.1674
Plasmodium vivax calcium-dependent protein kinase, putative 0.0079 0.0382 0.2623
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0213 0.2154 0.2627
Echinococcus multilocularis N chimaerin 0.0087 0.0489 0.0597
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.057 0.2197
Plasmodium falciparum protein kinase 5 0.0094 0.057 0.4998
Brugia malayi STE20-like kinase MST 0.0203 0.2014 0.2161
Entamoeba histolytica protein kinase, putative 0.008 0.0395 0.1195
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0278 0.3015 0.3257
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0079 0.0382 0.0414
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.2728 0.5316
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0068 0.0227 0.0186
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0146 0.1271 0.1549
Trichomonas vaginalis AGC family protein kinase 0.0237 0.2471 1
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.2154 0.8719
Entamoeba histolytica PH domain containing protein kinase, putative 0.013 0.1059 0.3202
Loa Loa (eye worm) protein kinase domain-containing protein 0.0168 0.1558 0.1695
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0115 0.0849 0.1035
Echinococcus multilocularis 0.0095 0.0594 0.0725
Echinococcus granulosus protein kinase shaggy 0.0101 0.0673 0.0634
Giardia lamblia Kinase, CMGC CDK 0.0094 0.057 0.1907
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0474 0.5603 0.6103
Schistosoma mansoni tyrosine kinase 0.0296 0.3249 0.6329
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.007 0.0262 0.0368
Echinococcus multilocularis cyclin dependent kinase 5 0.0094 0.057 0.0695
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Brugia malayi Protein kinase domain containing protein 0.0096 0.0606 0.0621
Echinococcus granulosus epidermal growth factor receptor 0.0367 0.4189 0.4164
Loa Loa (eye worm) hypothetical protein 0.0162 0.1478 0.1608
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0089 0.0509 0.1446
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0382 0.1546
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0171 0.1597 0.1738
Entamoeba histolytica protein kinase, putative 0.0096 0.0606 0.1831
Echinococcus multilocularis NCK adaptor protein 0.0079 0.0382 0.0466
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0089 0.0509 0.0621
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0055 0.0065 0.0079
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0199 0.1964 0.2394
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.0606 0.1866
Loa Loa (eye worm) hypothetical protein 0.0088 0.0501 0.0544
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0213 0.2154 0.2345
Trypanosoma brucei Casein kinase II 0.0079 0.0374 0.0857
Loa Loa (eye worm) raf kinase 0.0293 0.3216 0.3502
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0064 0.0178 0.0015
Onchocerca volvulus 0.0113 0.0826 0.1603
Echinococcus granulosus dual specificity 0.0096 0.0606 0.0566
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0109 0.0781 0.3051
Brugia malayi Protein kinase domain containing protein 0.0474 0.5603 0.6088
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0139 0.1166 0.1268
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0063 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.3722 0.7252
Entamoeba histolytica protein kinase, putative 0.0237 0.2471 0.747
Trypanosoma brucei protein kinase, putative 0.0101 0.0673 0.216
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0183 0.1755 0.191
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0781 0.316
Schistosoma mansoni tyrosine kinase 0.0319 0.3556 0.6928
Loa Loa (eye worm) hypothetical protein 0.0155 0.1384 0.1506
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0289 0.3164 0.3445
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0247 0.2607 0.3178
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.1995 0.3886
Echinococcus granulosus rho-associated protein kinase 1 0.0257 0.2728 0.2697
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0208 0.2091 0.255
Loa Loa (eye worm) hypothetical protein 0.0079 0.0382 0.0414
Echinococcus granulosus nervana 2 0.0098 0.0626 0.0586
Schistosoma mansoni protein kinase 0.0068 0.0227 0.0442
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0203 0.039
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0181 0.1724 0.1877
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0066 0.0203 0.0127
Schistosoma mansoni tyrosine kinase 0.0219 0.2231 0.4347
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0289 0.3164 0.3135
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0115 0.0849 0.2567
Schistosoma mansoni tyrosine kinase 0.0438 0.5132 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0079 0.0382 0.2623
Echinococcus granulosus Glutaredoxin protein 5 0.0098 0.0626 0.0586
Echinococcus granulosus casein kinase I gamma 0.0168 0.1558 0.1522
Trichomonas vaginalis CK1 family protein kinase 0.0085 0.0464 0.1877
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0079 0.0374 0.0406
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0132 0.1084 0.1322
Brugia malayi P38 map kinase family protein 2 0.0125 0.0992 0.1043
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0088 0.0501 0.1409
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0175 0.1652 0.1797
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0278 0.3015 0.2986
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0278 0.3015 0.5858
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0079 0.0382 0.0341
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0509 0.0993
Brugia malayi Protein kinase domain containing protein 0.0083 0.0437 0.0437
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Loa Loa (eye worm) hypothetical protein 0.0098 0.0623 0.0677
Trypanosoma brucei polo-like protein kinase 0.0213 0.2154 0.8619
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0849 0.3436
Echinococcus granulosus casein kinase I alpha 0.0085 0.0464 0.0423
Brugia malayi Protein kinase domain containing protein 0.0083 0.0437 0.0437
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0107 0.0751 0.2618
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.04
Entamoeba histolytica protein kinase, putative 0.0079 0.0382 0.1155
Loa Loa (eye worm) TK/INSR protein kinase 0.0319 0.3556 0.3872
Echinococcus multilocularis dual specificity 0.0096 0.0606 0.0739
Brugia malayi C1-like domain containing protein 0.0181 0.1724 0.1845
Schistosoma mansoni tyrosine kinase 0.0257 0.2737 0.5333
Echinococcus multilocularis tyrosine protein kinase shark 0.0252 0.2671 0.3256
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0087 0.0489 0.0449
Brugia malayi Protein kinase domain containing protein 0.0443 0.5195 0.5641
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0203 0.0822
Brugia malayi serine/threonine kinase 12 0.0115 0.0849 0.0887
Echinococcus granulosus cyclin dependent kinase 0.0094 0.057 0.053
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.0606 0.2165
Echinococcus multilocularis dual specificity 0.0109 0.0781 0.0952
Brugia malayi map kinase activated protein kinase protein 2 0.0311 0.3451 0.3733
Echinococcus granulosus epidermal growth factor receptor 0.0257 0.2737 0.2706
Echinococcus granulosus tyrosine protein kinase Fyn 0.0185 0.1787 0.1752
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0065 0.0196 0.0081
Schistosoma mansoni serine/threonine-protein kinase 0.013 0.1059 0.2063
Echinococcus multilocularis expressed conserved protein 0.0106 0.0735 0.0896
Echinococcus multilocularis mitogen activated protein kinase 3 0.0066 0.0203 0.0248
Echinococcus granulosus roundabout 2 0.011 0.0787 0.0748
Giardia lamblia Kinase, AGC PKA 0.0089 0.0509 0.1599
Echinococcus granulosus tyrosine protein kinase Src64B 0.0185 0.1787 0.1752
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.2154 0.8719
Echinococcus multilocularis expressed protein 0.0065 0.0196 0.0239
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0203 0.0822
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0649 0.2627
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0107 0.0751 0.7291
Brugia malayi Protein kinase domain containing protein 0.0071 0.0266 0.025
Schistosoma mansoni growth factor receptor-bound protein 0.0078 0.0361 0.0703
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.207 0.4033
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0673 0.2724
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0849 0.1654
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0079 0.0382 0.0942
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0148 0.1298 0.1412
Loa Loa (eye worm) hypothetical protein 0.011 0.0784 0.0852
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.057 0.2197
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0146 0.1271 0.1382
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.2154 0.8719
Entamoeba histolytica protein kinase domain containing protein 0.0079 0.0374 0.1132
Schistosoma mansoni tyrosine kinase 0.0219 0.2231 0.4347
Schistosoma mansoni tyrosine kinase 0.0195 0.1912 0.3725
Leishmania major casein kinase, putative 0.0085 0.0464 0.1446
Schistosoma mansoni protein kinase 0.0068 0.0227 0.0442
Giardia lamblia Kinase, CDC7 0.0071 0.0266 0.0356
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Echinococcus granulosus cGMP dependent protein kinase 1 0.0106 0.0735 0.0696
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0089 0.0509 0.0469
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0115 0.0849 0.2567
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Schistosoma mansoni rap gtpase-activating protein 0.0088 0.0501 0.0976
Echinococcus granulosus serine:threonine protein kinase 0.009 0.0521 0.0481
Brugia malayi Protein kinase domain containing protein 0.0278 0.3015 0.3257
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0509 0.2062
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0257 0.2737 0.2706
Trichomonas vaginalis STE family protein kinase 0.0067 0.0213 0.0861
Echinococcus granulosus CDC7 cell division cycle 7 0.0071 0.0266 0.0225
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0106 0.0735 0.0896
Loa Loa (eye worm) hypothetical protein 0.0285 0.3105 0.3381
Brugia malayi MAP kinase sur-1 0.0066 0.0203 0.0181
Schistosoma mansoni protein kinase 0.0064 0.0178 0.0347
Entamoeba histolytica protein kinase, putative 0.0071 0.0271 0.0819
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0066 0.0203 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0531 0.2149
Echinococcus granulosus casein kinase i 0.0085 0.0464 0.0423
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0311 0.3451 0.3423
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0098 0.0626 0.0763
Loa Loa (eye worm) casein kinase 0.0142 0.1218 0.1325
Entamoeba histolytica PH domain containing protein kinase, putative 0.0096 0.0603 0.1823
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0649 0.2627
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0203 0.039
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.1906 0.3714
Brugia malayi Kinase associated domain 1 family protein 0.0081 0.0398 0.0394
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0327 0.3658 0.446
Loa Loa (eye worm) AGC/PKN protein kinase 0.0235 0.244 0.2657
Schistosoma mansoni protein kinase 0.0115 0.0849 0.1654
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0185 0.1787 0.1752
Loa Loa (eye worm) hypothetical protein 0.0089 0.0509 0.0553
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0106 0.0735 0.0896
Schistosoma mansoni tyrosine kinase 0.0063 0.0166 0.0324
Onchocerca volvulus 0.0083 0.0437 0.0847
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0056 0.0068 0.0026
Echinococcus multilocularis serine:threonine protein kinase 3 0.0203 0.2014 0.2455
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0101 0.0673 0.0731
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0123 0.0965 1
Onchocerca volvulus 0.0071 0.0266 0.0514
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0934 0.182
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0063 0.017 0.0207
Loa Loa (eye worm) hypothetical protein 0.008 0.0396 0.043
Echinococcus multilocularis neuroglian 0.0083 0.0432 0.0526
Giardia lamblia Kinase, CK1 Casein kinase 0.0085 0.0464 0.1365
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.0178 0.0538
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.3015 0.5875
Brugia malayi Protein kinase domain containing protein 0.0152 0.1344 0.1429
Loa Loa (eye worm) hypothetical protein 0.0183 0.1758 0.1914
Entamoeba histolytica casein kinase, putative 0.0079 0.0374 0.1132
Schistosoma mansoni tyrosine kinase 0.0252 0.2671 0.5203
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0055 0.0063 0.0067
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0185 0.1787 0.2179
Schistosoma mansoni serine/threonine protein kinase 0.0311 0.3451 0.6723
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0089 0.0509 0.4234
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0327 0.3658 0.3631
Brugia malayi cell division control protein 2 homolog 0.0094 0.057 0.0582
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0063 0.0122
Schistosoma mansoni ste20-related kinase 0.0162 0.1473 0.287
Echinococcus multilocularis casein kinase i 0.0085 0.0464 0.0565
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0179 0.0726
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0606 0.1831
Trypanosoma cruzi Protein kinase B 0.013 0.1059 0.4606
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0342 0.3866 0.384
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.1906 0.3714
Entamoeba histolytica protein kinase, putative 0.0058 0.0094 0.0283
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0068 0.0227 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0738 0.1437
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0079 0.0382 0.0942
Echinococcus granulosus protein kinase c epsilon type 0.0175 0.1655 0.162
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0121 0.0934 0.1016
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0056 0.0068 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0132 0.1084 0.1046
Schistosoma mansoni cell adhesion molecule 0.0093 0.056 0.1091
Brugia malayi p70 ribosomal S6 kinase beta 0.023 0.2377 0.2559
Echinococcus multilocularis dual specificity 0.0109 0.0781 0.0952
Echinococcus granulosus serine:threonine protein kinase MARK2 0.017 0.1587 0.1551
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0263 0.2816 0.3039
Trichomonas vaginalis AGC family protein kinase 0.0237 0.2471 1
Echinococcus multilocularis 0.0121 0.0929 0.1133
Brugia malayi Protein kinase domain containing protein 0.0168 0.1558 0.1662
Loa Loa (eye worm) hypothetical protein 0.0066 0.0205 0.0221
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0064 0.0179 0.0219
Loa Loa (eye worm) hypothetical protein 0.0088 0.0501 0.0544
Echinococcus granulosus tyrosine protein kinase Fyn 0.0185 0.1787 0.1752
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0066 0.0203 0.0129
Entamoeba histolytica protein kinase, putative 0.0096 0.0606 0.1831
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.007 0.0254 0.0275
Plasmodium falciparum glycogen synthase kinase 3 0.0101 0.0673 0.6303
Giardia lamblia Kinase, PLK 0.0213 0.2154 1
Toxoplasma gondii casein kinase I 0.0085 0.0464 0.1313
Loa Loa (eye worm) TK/FER protein kinase 0.0323 0.3611 0.3932
Echinococcus granulosus mitogen activated protein kinase 11 0.0125 0.0992 0.0954
Brugia malayi hypothetical protein 0.0078 0.0369 0.0362
Brugia malayi Protein kinase domain containing protein 0.0237 0.2471 0.2661
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0132 0.1084 0.1046
Trypanosoma cruzi aurora B kinase, putative 0.0115 0.0849 0.3571
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0185 0.1787 0.2179
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0278 0.3015 0.3283
Echinococcus granulosus twitchin 0.0109 0.0772 0.0733
Trypanosoma cruzi casein kinase, putative 0.0085 0.0464 0.1674
Loa Loa (eye worm) hypothetical protein 0.011 0.0784 0.0852
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0185 0.1787 0.2179
Echinococcus granulosus calcium activated potassium channel 0.0106 0.0738 0.0698
Brugia malayi Protein kinase domain containing protein 0.0148 0.1298 0.1378
Echinococcus multilocularis cyclin dependent kinase 0.0094 0.057 0.0695
Entamoeba histolytica serine/threonine protein kinase, putative 0.007 0.0262 0.0793
Echinococcus multilocularis serine:threonine protein kinase N2 0.0132 0.1084 0.1322
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0088 0.0501 0.1857
Giardia lamblia Kinase, AGC PKA 0.0123 0.0965 0.3928
Schistosoma mansoni protein kinase 0.0064 0.0178 0.0347
Entamoeba histolytica PH domain containing protein kinase, putative 0.0096 0.0603 0.1823
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0079 0.0382 0.0942
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0121 0.0934 0.3991
Echinococcus multilocularis casein kinase ii subunit alpha 0.0079 0.0374 0.0456
Brugia malayi Immunoglobulin I-set domain containing protein 0.0502 0.5983 0.6503
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0087 0.0489 0.0597
Trichomonas vaginalis AGC family protein kinase 0.0237 0.2471 1
Entamoeba histolytica protein kinase, putative 0.0115 0.0849 0.2567
Brugia malayi Casein kinase II, alpha chain 0.0079 0.0374 0.0368
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.0606 0.0658
Echinococcus granulosus homeodomain interacting protein kinase 3 0.016 0.1447 0.141
Brugia malayi Protein kinase domain containing protein 0.0129 0.1044 0.11
Entamoeba histolytica hypothetical protein 0.0096 0.0606 0.1831
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0056 0.0068 0.0083
Echinococcus multilocularis serine:threonine kinase SAD 1 0.007 0.0262 0.032
Loa Loa (eye worm) AUR protein kinase 0.0115 0.0849 0.0923
Brugia malayi Immunoglobulin I-set domain containing protein 0.0212 0.2139 0.2298
Entamoeba histolytica protein kinase, putative 0.0065 0.0196 0.0594
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0775
Plasmodium vivax casein kinase 1, putative 0.0085 0.0464 0.3656
Loa Loa (eye worm) AUR protein kinase 0.0115 0.0849 0.0923
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0089 0.0509 0.152
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0078 0.0361 0.0703
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0065 0.0196 0.0212
Echinococcus granulosus defective proboscis extension response 0.0066 0.0205 0.0163
Echinococcus granulosus tyrosine protein kinase Src42A 0.0185 0.1787 0.1752
Loa Loa (eye worm) hypothetical protein 0.0113 0.0826 0.0898
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.057 0.2306
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0374 0.1515
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Schistosoma mansoni tyrosine kinase 0.0257 0.2737 0.5333
Brugia malayi Protein kinase domain containing protein 0.0319 0.3556 0.3848
Echinococcus granulosus serine:threonine protein kinase 0.009 0.0521 0.0481
Onchocerca volvulus 0.0083 0.0437 0.0847
Echinococcus multilocularis epidermal growth factor receptor 0.0367 0.4189 0.5107
Schistosoma mansoni tyrosine kinase 0.0116 0.0867 0.1689
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0114 0.0841 0.0802
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0781 0.1521
Loa Loa (eye worm) hypothetical protein 0.007 0.0262 0.0284
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0158 0.1427 0.1553
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0934 0.182
Echinococcus granulosus casein kinase I alpha 0.0085 0.0464 0.0423
Loa Loa (eye worm) TK protein kinase 0.0212 0.2139 0.2329
Loa Loa (eye worm) AGC/NDR protein kinase 0.0132 0.1084 0.1179
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0115 0.0849 0.081
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.0849 0.2567
Brugia malayi Doublecortin family protein 0.0119 0.0905 0.0948
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0195 0.1912 0.2331
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0079 0.0382 0.2623
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0094 0.057 0.1983
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0849 0.3436
Echinococcus multilocularis 0.0101 0.0663 0.0808
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0781 0.316
Echinococcus granulosus dual specificity 0.0109 0.0781 0.0742
Brugia malayi protein unc-22 0.0055 0.0063 0.0027
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0064 0.0178 0.0266
Echinococcus granulosus titin 0.0055 0.0063 0.0021
Plasmodium falciparum calcium-dependent protein kinase 5 0.0079 0.0382 0.2623
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0263 0.2816 0.3066
Echinococcus multilocularis serine:threonine protein kinase N2 0.0235 0.244 0.2975
Loa Loa (eye worm) hypothetical protein 0.0071 0.0266 0.0288
Echinococcus granulosus growth factor receptor bound protein 2 0.0079 0.0382 0.0341
Plasmodium falciparum protein serine/threonine kinase-1 0.0121 0.0934 0.9605
Onchocerca volvulus Tyrosine kinase homolog 0.0439 0.5146 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0392
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.023 0.2377 0.2588
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0079 0.0374 0.2526
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.1271 0.2476
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0185 0.1785 0.1943
Brugia malayi intracellular kinase 0.0101 0.0673 0.0695
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0068 0.0133
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0058 0.01 0.0107
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0087 0.0489 0.0954
Plasmodium falciparum casein kinase 2, alpha subunit 0.0079 0.0374 0.2526
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.016 0.1447 0.1764
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0078 0.0361 0.0392
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0066 0.0203 0.039
Echinococcus multilocularis rho associated protein kinase 0.0257 0.2728 0.3326
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0079 0.0382 0.0466
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0109 0.0781 0.263
Schistosoma mansoni vam6/vps39 related 0.0088 0.0501 0.0976
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0066 0.0203 0.039
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0079 0.0382 0.0466
Loa Loa (eye worm) TK/EPH protein kinase 0.0103 0.0691 0.0751
Trypanosoma cruzi rac serine-threonine kinase, putative 0.013 0.1059 0.4606
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.057 0.0695
Echinococcus granulosus raf serine:threonine protein kinase 0.0332 0.3722 0.3696
Loa Loa (eye worm) TK protein kinase 0.0153 0.1357 0.1477
Echinococcus granulosus serine:threonine protein kinase 3 0.0203 0.2014 0.198
Loa Loa (eye worm) hypothetical protein 0.0095 0.0594 0.0646
Brugia malayi Variant SH3 domain containing protein 0.0078 0.0361 0.0353
Entamoeba histolytica protein kinase, putative 0.0109 0.0781 0.2361
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0208 0.2091 0.2277
Brugia malayi Protein kinase domain containing protein 0.0289 0.3164 0.3419
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0738 0.1437
Loa Loa (eye worm) hypothetical protein 0.0189 0.184 0.2003
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0087 0.0489 0.0531
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0101 0.0673 0.0821
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0129 0.1044 0.1006
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0125 0.0992 0.1079
Giardia lamblia Kinase, CAMK CAMKL 0.007 0.0262 0.0337
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0085 0.0464 0.0503
Onchocerca volvulus 0.0257 0.2728 0.53
Loa Loa (eye worm) hypothetical protein 0.0094 0.0576 0.0626
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0502 0.5983 0.6517
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.057 0.0619
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.007 0.0262 0.0284
Brugia malayi Protein kinase domain containing protein 0.0083 0.0437 0.0437
Echinococcus granulosus casein kinase I delta 0.0085 0.0464 0.0423
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Onchocerca volvulus Serine\/threonine kinase homolog 0.0129 0.1044 0.2025
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0213 0.2154 1
Entamoeba histolytica protein kinase domain containing protein 0.016 0.1447 0.4374
Echinococcus multilocularis dual specificity 0.0109 0.0781 0.0952
Plasmodium falciparum NIMA related kinase 1 0.0107 0.0751 0.7291
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0129 0.1044 0.1135
Onchocerca volvulus 0.0384 0.4413 0.8575
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0194 0.1906 0.1872
Onchocerca volvulus 0.0231 0.2388 0.4639
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0152 0.1344 0.1462
Trypanosoma cruzi casein kinase, putative 0.0085 0.0464 0.1674
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0331 0.3719 0.3693
Brugia malayi Protein kinase domain containing protein 0.0228 0.2346 0.2525
Brugia malayi Tyrosine-protein kinase abl-1 0.0179 0.1697 0.1814
Echinococcus multilocularis protein tyrosine kinase 0.0438 0.5132 0.6258
Entamoeba histolytica protein kinase, putative 0.0068 0.0227 0.0686
Schistosoma mansoni growth factor receptor-bound protein 0.0079 0.0382 0.0744
Loa Loa (eye worm) TK protein kinase 0.0108 0.0758 0.0824
Echinococcus granulosus casein kinase I alpha 0.0085 0.0464 0.0423
Brugia malayi serine/threonine-protein kinase PAK 7 0.0183 0.1755 0.1878
Brugia malayi Furin-like cysteine rich region family protein 0.0367 0.4189 0.454
Schistosoma mansoni protein kinase 0.0064 0.0178 0.0347
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0278 0.3015 0.3283
Trypanosoma cruzi casein kinase II, putative 0.0079 0.0374 0.1234
Trichomonas vaginalis STE family protein kinase 0.0068 0.0227 0.0918
Schistosoma mansoni protein kinase 0.0342 0.3866 0.7533
Brugia malayi Sex muscle abnormal protein 5 0.0078 0.0361 0.0353
Loa Loa (eye worm) hypothetical protein 0.0083 0.0437 0.0474
Echinococcus granulosus tyrosine protein kinase shark 0.0252 0.2671 0.264
Entamoeba histolytica protein kinase domain containing protein 0.0109 0.0781 0.2361
Loa Loa (eye worm) hypothetical protein 0.0052 0.0025 0.0025
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0114 0.0841 0.1025
Trypanosoma brucei SNF1-related protein kinases, putative 0.007 0.0262 0.0368
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0088 0.0501 0.1857
Trichomonas vaginalis STE family protein kinase 0.0107 0.0751 0.304
Brugia malayi Immunoglobulin I-set domain containing protein 0.0078 0.0369 0.0362
Entamoeba histolytica hypothetical protein 0.03 0.3308 1
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0068 0.0227 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0203 0.0822
Schistosoma mansoni serine/threonine kinase 0.0132 0.1084 0.2112
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0311 0.3451 0.4207
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0185 0.1787 0.2179
Toxoplasma gondii AGC kinase 0.023 0.2377 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0501 0.0544
Brugia malayi protein kinase C II. 0.0175 0.1655 0.1769
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0262 0.0511
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0374 0.1515
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0089 0.0509 0.0621
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0437 0.0474
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0064 0.0179 0.0138
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0106 0.0735 0.2544
Entamoeba histolytica protein kinase, putative 0.0101 0.0673 0.2035
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0089 0.0509 0.0621
Echinococcus granulosus c src tyrosine kinase 0.0116 0.0867 0.0828
Brugia malayi Protein kinase c protein 2 0.01 0.0658 0.0678
Echinococcus granulosus dual specificity protein kinase clk2 0.0121 0.0934 0.0896
Entamoeba histolytica protein kinase, putative 0.0115 0.0849 0.2567
Onchocerca volvulus 0.0162 0.1478 0.287
Echinococcus granulosus titin 0.0055 0.0063 0.0021
Echinococcus granulosus expressed protein 0.0065 0.0196 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Schistosoma mansoni ephrin receptor 0.0051 0.0002 0.0004
Brugia malayi putative serine/threonine kinase SADA gamma 0.007 0.0262 0.0245
Echinococcus granulosus c-Jun N-terminal kinases 0.0208 0.2091 0.2058
Schistosoma mansoni nck2/grb4 0.0078 0.0361 0.0703
Schistosoma mansoni tyrosine kinase 0.0219 0.2231 0.4347
Plasmodium falciparum serine/threonine protein kinase KIN 0.007 0.0262 0.111
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0068 0.0227 0.0186
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0185 0.1787 0.2179
Echinococcus granulosus Immunoglobulin 0.0066 0.0205 0.0163
Brugia malayi SH2 domain containing protein 0.0083 0.0437 0.0437
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0115 0.0849 0.8527
Echinococcus granulosus tyrosine protein kinase 0.0228 0.2346 0.2314
Loa Loa (eye worm) hypothetical protein 0.0365 0.4159 0.4529
Onchocerca volvulus 0.0083 0.0437 0.0847
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0066 0.0205 0.025
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0185 0.1787 0.2179
Echinococcus granulosus cGMP dependent protein kinase 0.0106 0.0735 0.0696
Echinococcus multilocularis casein kinase I alpha 0.0085 0.0464 0.0565
Trypanosoma brucei protein kinase, putative 0.0066 0.0203 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.1558 0.3035
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0067 0.0213 0.0643
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0114 0.0842 0.1027
Plasmodium falciparum protein kinase, putative 0.0064 0.0178 0.0042
Brugia malayi serine/threonine protein kinase 6 0.0115 0.0849 0.0887
Schistosoma mansoni protein kinase 0.0342 0.3866 0.7533
Echinococcus granulosus mitogen activated protein kinase 0.0066 0.0203 0.0162
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0109 0.0781 0.3236
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0125 0.0992 0.4117
Brugia malayi Protein kinase domain containing protein 0.0094 0.057 0.0582
Leishmania major protein kinase A catalytic subunit isoform 2 0.0089 0.0509 0.1677
Loa Loa (eye worm) hypothetical protein 0.011 0.0784 0.0852
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.057 0.2306
Schistosoma mansoni protein kinase 0.0079 0.0374 0.0729
Brugia malayi Protein kinase domain containing protein 0.0354 0.4019 0.4355
Onchocerca volvulus 0.0088 0.0501 0.097
Entamoeba histolytica serine/threonine protein kinase, putative 0.0213 0.2154 0.6513
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0088 0.0501 0.0611
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0509 0.0993
Echinococcus granulosus mitogen activated protein kinase 14 0.0125 0.0992 0.0954
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0273 0.294 0.3202
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0849 0.3436
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0121 0.0934 0.3991
Loa Loa (eye worm) hypothetical protein 0.0474 0.5603 0.6103
Brugia malayi protein kinase C3,putative 0.0133 0.1097 0.1159
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0089 0.0509 0.0469
Toxoplasma gondii AGC kinase 0.0089 0.0509 0.152
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0071 0.0271 0.0819
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0289 0.3164 0.3857
Echinococcus multilocularis protein kinase shaggy 0.0101 0.0673 0.0821
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0158 0.1427 0.174
Echinococcus granulosus serine:threonine protein kinase MARK2 0.017 0.1587 0.1551
Echinococcus multilocularis c src tyrosine kinase 0.0116 0.0867 0.1057
Echinococcus multilocularis insulin receptor 0.0319 0.3556 0.4335
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0437 0.0474
Echinococcus granulosus aurora kinase A 0.0115 0.0849 0.081
Brugia malayi Egg laying defective protein 4 0.0106 0.0735 0.0763
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0437 0.0474
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0179 0.0726
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0068 0.0227 0.0277
Onchocerca volvulus 0.0083 0.0437 0.0847
Echinococcus multilocularis serine threonine protein kinase 0.0165 0.1512 0.1843
Entamoeba histolytica protein kinase , putative 0.0115 0.0849 0.2567
Entamoeba histolytica protein kinase, putative 0.0056 0.0068 0.0206
Schistosoma mansoni serine/threonine-protein kinase 0.013 0.1059 0.2063
Echinococcus multilocularis mitogen activated protein kinase 11 0.0125 0.0992 0.1209
Brugia malayi Stress-activated protein kinase jnk-1 0.0208 0.2091 0.2246
Echinococcus multilocularis Immunoglobulin 0.0066 0.0205 0.025
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0089 0.0509 0.1899
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0114 0.0842 0.0803
Schistosoma mansoni vav2 0.0094 0.0583 0.1136
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0374 0.1515
Brugia malayi Protein kinase domain containing protein 0.0474 0.5603 0.6088
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0089 0.0509 0.0516
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0203 0.0822
Brugia malayi RhoGAP domain containing protein 0.0087 0.0489 0.0494
Plasmodium falciparum calcium-dependent protein kinase 4 0.0079 0.0382 0.2623
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0125 0.0992 0.4274
Schistosoma mansoni tyrosine kinase 0.0185 0.1787 0.3482
Schistosoma mansoni tyrosine kinase 0.0202 0.2008 0.3912
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0175 0.1655 0.1802
Onchocerca volvulus 0.0083 0.0437 0.0847
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0195 0.1912 0.2331
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1587 0.3091
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0934 0.3781
Leishmania major protein kinase A catalytic subunit 0.0089 0.0509 0.1677
Loa Loa (eye worm) hypothetical protein 0.0071 0.0266 0.0288
Echinococcus multilocularis casein kinase I alpha 0.0085 0.0464 0.0565
Brugia malayi Raf kinase 0.0289 0.3164 0.3419
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0115 0.0849 0.2567
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0213 0.2154 0.2121
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0088 0.0501 0.0976
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0123 0.0965 1
Brugia malayi Protein kinase domain containing protein 0.0132 0.1084 0.1144
Entamoeba histolytica protein kinase, putative 0.023 0.2377 0.7188
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0262 0.0511
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0089 0.0509 0.1899
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0067 0.0213 0.0152
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0474 0.5603 0.6103
Trichomonas vaginalis CAMK family protein kinase 0.0171 0.1597 0.6462
Schistosoma mansoni adapter molecule crk 0.0078 0.0361 0.0703
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.2154 0.8719
Echinococcus multilocularis tyrosine protein kinase Blk 0.0153 0.1357 0.1655
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0606 0.118
Echinococcus multilocularis raf serine:threonine protein kinase 0.0332 0.3722 0.4538
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0374 0.1515
Plasmodium vivax glycogen synthase kinase 3, putative 0.0101 0.0673 0.6303
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0066 0.0203 0.0127
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0079 0.0382 0.089
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.057 0.2197
Brugia malayi phosphoinositide-dependent protein kinase I 0.0064 0.0179 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1587 0.3091
Leishmania major protein kinase, putative 0.0121 0.0934 0.3827
Brugia malayi Homeodomain interacting protein kinase protein 1 0.016 0.1447 0.1541
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0138 0.1161 0.1263
Brugia malayi Hr1 repeat family protein 0.0235 0.244 0.2628
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0437 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0464 0.0904
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0101 0.0673 0.1311
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0064 0.0178 0.0136
Giardia lamblia Kinase, CMGC GSK 0.0101 0.0673 0.2435
Schistosoma mansoni protein kinase 0.0209 0.2098 0.4088
Giardia lamblia Kinase, CMGC CDK 0.0094 0.057 0.1907
Echinococcus granulosus serine:threonine kinase SAD 1 0.007 0.0262 0.0221
Trypanosoma brucei rac serine-threonine kinase, putative 0.0237 0.2471 1
Trypanosoma brucei aurora B kinase 0.0115 0.0849 0.2927
Echinococcus granulosus fibroblast growth factor receptor 4 0.0195 0.1912 0.1878
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0064 0.0178 0.0266
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.017 0.1587 0.1935
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Echinococcus granulosus NDR protein kinase 0.0132 0.1084 0.1046
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0606 0.2373
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0181 0.1724 0.1845
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0109 0.0781 0.2752
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0116 0.0867 0.1689
Entamoeba histolytica protein kinase, putative 0.0056 0.0068 0.0206
Trichomonas vaginalis AGC family protein kinase 0.0148 0.1298 0.5252
Echinococcus multilocularis mitogen activated protein kinase 0.0066 0.0203 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0237 0.2471 1
Leishmania major protein kinase, putative 0.0079 0.0382 0.1033
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0158 0.1427 0.139
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0195 0.1912 0.1878
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0146 0.1271 0.1234
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0065 0.0196 0.0094
Plasmodium falciparum cGMP-dependent protein kinase 0.0106 0.0735 0.7086
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0065 0.0196 0.0357
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.057 0.111
Schistosoma mansoni serine/threonine protein kinase 0.0377 0.4316 0.841
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.007 0.0262 0.0682
Brugia malayi Protein kinase domain containing protein 0.0065 0.0196 0.0173
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0203 0.2014 0.2192
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0175 0.1652 0.2014
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0064 0.0179 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0064 0.0179 0.0194
Echinococcus multilocularis CDC7 cell division cycle 7 0.0071 0.0266 0.0324
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0123 0.0965 0.1177
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0101 0.0673 0.0731
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.007 0.0262 0.0427
Echinococcus multilocularis activin receptor type 0.0064 0.0178 0.0217
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0354 0.4019 0.4377
Echinococcus granulosus nervana 2 0.0098 0.0626 0.0586
Brugia malayi Protein kinase domain containing protein 0.0225 0.2313 0.2488
Brugia malayi casein kinase 1, delta 0.0085 0.0464 0.0466
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Echinococcus granulosus tyrosine kinase 0.0083 0.0437 0.0397
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0089 0.0509 0.1899
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0053 0.0038 0.0039
Entamoeba histolytica casein kinase 1, putative 0.0085 0.0464 0.1402
Echinococcus granulosus N chimaerin 0.0087 0.0489 0.0449
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.039 0.4498 0.5485
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0091 0.0531 0.0647
Brugia malayi serine/threonine-protein kinase plk-2 0.0213 0.2154 0.2315
Brugia malayi Protein kinase domain containing protein 0.0158 0.1427 0.152
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.2154 0.8719
Mycobacterium ulcerans hypothetical protein 0.008 0.0395 0.5
Trichomonas vaginalis STE family protein kinase 0.0068 0.0227 0.0918
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0123 0.0965 0.0927
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.2154 0.8719
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0067 0.0213 0.0437
Loa Loa (eye worm) hypothetical protein 0.0164 0.151 0.1643
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0101 0.0673 0.2263
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0849 0.3436
Brugia malayi casein kinase I 0.0085 0.0464 0.0466
Brugia malayi Protein kinase domain 0.0068 0.0227 0.0207
Trichomonas vaginalis CK1 family protein kinase 0.0085 0.0464 0.1877
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0109 0.0781 0.0849
Echinococcus multilocularis casein kinase I delta 0.0085 0.0464 0.0565
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0066 0.0203 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.1964 0.3826
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.057 0.2197
Echinococcus multilocularis casein kinase I gamma 0.0168 0.1558 0.1899
Brugia malayi Variant SH3 domain containing protein 0.0087 0.0489 0.0494
Toxoplasma gondii AGC kinase 0.0089 0.0509 0.152
Trichomonas vaginalis AGC family protein kinase 0.0132 0.1084 0.4386
Brugia malayi Protein kinase domain containing protein 0.0744 0.918 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0123 0.0958 0.3876
Echinococcus multilocularis nervana 2 0.0098 0.0626 0.0763
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0744 0.918 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0089 0.0509 0.0553
Brugia malayi Serine/threonine-protein kinase SULU 0.0175 0.1652 0.1765
Schistosoma mansoni vesicular amine transporter 0.0066 0.0205 0.0399
Plasmodium vivax serine/threonine protein kinase, putative 0.0065 0.0196 0.0277
Schistosoma mansoni ephrin receptor 0.0089 0.0508 0.0989
Echinococcus multilocularis calcium dependent protein kinase 0.0054 0.0042 0.0051
Echinococcus multilocularis Immunoglobulin 0.0066 0.0205 0.025
Trypanosoma cruzi SNF1-related protein kinases, putative 0.007 0.0262 0.0682
Echinococcus multilocularis nervana 2 0.0098 0.0626 0.0763
Entamoeba histolytica protein kinase, putative 0.0108 0.0758 0.2292
Trichomonas vaginalis AGC family protein kinase 0.0237 0.2471 1
Schistosoma mansoni protein kinase 0.0342 0.3866 0.7533
Echinococcus granulosus protein tyrosine kinase 0.0438 0.5132 0.5112
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0673 0.2035
Brugia malayi Protein kinase domain containing protein 0.0083 0.0437 0.0437
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.2154 0.8719
Echinococcus multilocularis tyrosine protein kinase 0.0228 0.2346 0.2861
Trypanosoma brucei casein kinase I, isoform 2 0.0085 0.0464 0.1247
Echinococcus multilocularis roundabout 2 0.011 0.0787 0.096
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1652 0.3218
Brugia malayi hypothetical protein 0.0083 0.0437 0.0437
Schistosoma mansoni tyrosine kinase 0.0116 0.0867 0.1689
Onchocerca volvulus 0.0055 0.0063 0.0119
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0153 0.1357 0.1321
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0092 0.0552 0.0562
Brugia malayi protein-tyrosine kinase 0.0153 0.1357 0.1443
Brugia malayi hypothetical protein 0.0175 0.1652 0.1765
Echinococcus multilocularis protein kinase c epsilon type 0.0175 0.1655 0.2018
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0085 0.0464 0.0503
Onchocerca volvulus 0.0058 0.0102 0.0194
Echinococcus granulosus Protein kinase C brain isozyme 0.0207 0.207 0.2037
Echinococcus granulosus tyrosine protein kinase ABL1 0.0247 0.2607 0.2576
Echinococcus granulosus mitogen activated protein kinase 3 0.0066 0.0203 0.0162
Onchocerca volvulus 0.0085 0.0464 0.0898
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0088 0.0501 0.0976
Echinococcus multilocularis protein kinase c iota type 0.024 0.2509 0.306
Loa Loa (eye worm) TK protein kinase 0.0278 0.3012 0.3279
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0323 0.3611 0.4403
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.008 0.0396 0.0356
Entamoeba histolytica protein kinase, putative 0.0237 0.2471 0.747
Schistosoma mansoni protein kinase 0.0289 0.3164 0.6164
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0437 0.0474
Loa Loa (eye worm) hypothetical protein 0.0074 0.0305 0.0331
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0331 0.3719 0.4535
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0185 0.1787 0.2179
Trichomonas vaginalis AGC family protein kinase 0.0156 0.1391 0.563
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.007 0.0262 0.111
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0278 0.3015 0.3676
Loa Loa (eye worm) hypothetical protein 0.0098 0.0623 0.0677
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.1084 0.2112
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0121 0.0934 0.3299
Entamoeba histolytica protein kinase, putative 0.0058 0.0094 0.0283
Brugia malayi Protein kinase domain containing protein 0.0152 0.134 0.1424
Schistosoma mansoni titin 0.0055 0.0063 0.0122
Trypanosoma brucei cdc2-related kinase 1 0.0094 0.057 0.1709
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0175 0.1652 0.1616
Echinococcus multilocularis tyrosine protein kinase Srms 0.0153 0.1357 0.1655
Leishmania major protein kinase, putative 0.0121 0.0934 0.3827
Echinococcus granulosus cyclin dependent kinase 5 0.0094 0.057 0.053
Toxoplasma gondii CMGC kinase, CK2 family 0.0079 0.0374 0.0907
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.057 0.0695
Giardia lamblia Aurora kinase 0.0115 0.0849 0.3333
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0266 0.1077
Echinococcus multilocularis growth factor receptor bound protein 2 0.0078 0.0361 0.044
Loa Loa (eye worm) TK protein kinase 0.0228 0.2346 0.2554
Loa Loa (eye worm) hypothetical protein 0.0066 0.0205 0.0221
Echinococcus multilocularis serine:threonine protein kinase N2 0.0102 0.0688 0.0839
Echinococcus granulosus serine/threonine protein kinase 0.013 0.1059 0.1021
Echinococcus granulosus tyrosine protein kinase Blk 0.0153 0.1357 0.1321
Giardia lamblia Kinase, CMGC CK2 0.0079 0.0374 0.0909
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.1427 0.2781
Echinococcus granulosus casein kinase I delta 0.0085 0.0464 0.0423
Loa Loa (eye worm) TK/ROR protein kinase 0.0055 0.0065 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0735 0.1432
Schistosoma mansoni serine/threonine protein kinase 0.016 0.1447 0.2819
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0116 0.0872 0.1063
Trypanosoma cruzi casein kinase, putative 0.0085 0.0464 0.1674
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0775
Loa Loa (eye worm) SRC-1 0.0185 0.1787 0.1945
Echinococcus granulosus NCK adaptor protein 0.0078 0.0361 0.032
Loa Loa (eye worm) hypothetical protein 0.0113 0.0826 0.0898
Brugia malayi Fibronectin type III domain containing protein 0.0078 0.0369 0.0362
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0437 0.0474
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0094 0.057 0.053
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0078 0.0361 0.0392
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0083 0.0437 0.1322
Giardia lamblia Kinase, STE STE20 0.0067 0.0213 0.0083
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0056 0.0068 0.0026
Loa Loa (eye worm) hypothetical protein 0.0068 0.023 0.0249
Brugia malayi Temporarily assigned gene name protein 59 0.0088 0.0501 0.0506
Onchocerca volvulus 0.006 0.0124 0.0237
Trichomonas vaginalis STE family protein kinase 0.0068 0.0227 0.0918
Echinococcus granulosus serine:threonine protein kinase N2 0.0235 0.244 0.2408
Brugia malayi Temporarily assigned gene name protein 59 0.0102 0.0681 0.0704
Echinococcus multilocularis serine:threonine protein kinase 38 0.0132 0.1084 0.1322
Brugia malayi serine/threonine-protein kinase 6 0.0115 0.0849 0.0887
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0079 0.0382 0.0466
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0087 0.0489 0.0954
Schistosoma mansoni tyrosine kinase 0.0319 0.3556 0.6928
Schistosoma mansoni protein kinase 0.0152 0.1344 0.2619
Plasmodium falciparum serine/threonine protein kinase 0.0065 0.0196 0.0277
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.016 0.1447 0.1574
Echinococcus granulosus dual specificity 0.0109 0.0781 0.0742
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0121 0.0934 0.3449
Leishmania major protein kinase A catalytic subunit isoform 1 0.0089 0.0509 0.1677
Echinococcus granulosus hypothetical protein 0.0095 0.0594 0.0555
Giardia lamblia Kinase, CMGC MAPK 0.0066 0.0203 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.057 0.111
Echinococcus multilocularis myosin iiia 0.0067 0.0213 0.0259
Schistosoma mansoni protein kinase 0.0121 0.0929 0.181
Echinococcus granulosus serine threonine protein kinase nrc 0.0123 0.0965 0.0927
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0088 0.0501 0.0461
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.2091 0.4075
Entamoeba histolytica p21-activated kinase 0.0075 0.032 0.0969
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0203 0.0396
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0781 0.316
Brugia malayi Variant SH3 domain containing protein 0.0078 0.0361 0.0353
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0109 0.0781 0.0813
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0342 0.3866 0.4714
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0089 0.0509 0.1446
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0089 0.0509 0.0621
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0098 0.0626 0.0586
Echinococcus multilocularis Glutaredoxin protein 5 0.0098 0.0626 0.0763
Entamoeba histolytica protein kinase, putative 0.0065 0.0196 0.0594
Plasmodium falciparum calcium-dependent protein kinase 2 0.0079 0.0382 0.2623
Echinococcus granulosus neuroglian 0.0083 0.0432 0.0391
Echinococcus multilocularis aurora kinase A 0.0115 0.0849 0.1035
Schistosoma mansoni nephrin 0.0095 0.0596 0.116
Trypanosoma cruzi polo-like protein kinase, putative 0.0213 0.2154 1
Echinococcus multilocularis hypothetical protein 0.0081 0.0398 0.0485
Plasmodium falciparum serine/threonine protein kinase, putative 0.0115 0.0849 0.8527
Loa Loa (eye worm) hypothetical protein 0.0285 0.3105 0.3381
Giardia lamblia Kinase, AGC AKT 0.0092 0.0552 0.1815
Entamoeba histolytica casein kinase, putative 0.0085 0.0464 0.1402
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0266 0.1077
Giardia lamblia Kinase, CAMK CAMKL 0.007 0.0262 0.0337
Entamoeba histolytica protein kinase 2, putative 0.0123 0.0965 0.2919
Brugia malayi Protein kinase domain containing protein 0.0121 0.0934 0.098
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0121 0.0934 0.3991
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0094 0.057 0.1983
Brugia malayi Protein kinase domain containing protein 0.009 0.0521 0.0528
Onchocerca volvulus 0.011 0.0784 0.152
Brugia malayi Protein kinase domain containing protein 0.0064 0.0179 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.0235 0.244 0.4754
Schistosoma mansoni tyrosine kinase 0.007 0.0256 0.05
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0079 0.0382 0.0376
Echinococcus multilocularis ephrin type A receptor 4 A 0.0089 0.0508 0.0619
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0091 0.0531 0.0491
Brugia malayi SH2 domain containing protein 0.0323 0.3611 0.3908
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0153 0.1357 0.1655
Loa Loa (eye worm) TK/ALK protein kinase 0.0225 0.2312 0.2517
Brugia malayi Protein kinase domain containing protein 0.0162 0.1474 0.1571
Echinococcus multilocularis epidermal growth factor receptor 0.0257 0.2737 0.3337
Loa Loa (eye worm) TK/FAK protein kinase 0.0443 0.5195 0.5659
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0066 0.0205 0.0399
Echinococcus multilocularis tyrosine protein kinase HCK 0.0108 0.0758 0.0924
Echinococcus multilocularis tyrosine protein kinase Abl 0.0179 0.1697 0.2069
Loa Loa (eye worm) TK/EGFR protein kinase 0.0367 0.4189 0.4562
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0125 0.0992 0.4274
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0064 0.0178 0.0217
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.04
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0121 0.0934 0.3991
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.007 0.0262 0.0427
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0738 0.1437
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.1044 0.2033
Loa Loa (eye worm) AGC/PKG protein kinase 0.0106 0.0735 0.0799
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0437 0.0474
Echinococcus granulosus cGMP dependent protein kinase 1 0.0106 0.0735 0.0696
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1655 0.3225
Onchocerca volvulus Serine\/threonine kinase homolog 0.0213 0.2154 0.4184
Trypanosoma cruzi polo-like protein kinase, putative 0.0213 0.2154 1
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0437 0.0474
Leishmania major casein kinase II, putative 0.0079 0.0374 0.0994
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0094 0.057 0.0619
Loa Loa (eye worm) CAMK protein kinase 0.0055 0.0063 0.0067
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0068 0.0227 0.0277
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0207 0.207 0.2524
Echinococcus multilocularis mitogen activated protein kinase 11 0.0125 0.0992 0.1209
Echinococcus granulosus tyrosine protein kinase Lyn 0.0211 0.2127 0.2094
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0199 0.1964 0.193
Echinococcus granulosus tyrosine kinase 0.0153 0.1357 0.1321
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0185 0.1787 0.2179
Giardia lamblia Kinase, CMGC DYRK 0.0109 0.0781 0.2985
Brugia malayi ephrin receptor 1 precursor 0.0062 0.0154 0.0127
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0194 0.1906 0.2324
Leishmania major protein kinase, putative 0.0067 0.0213 0.0176
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0606 0.2373
Loa Loa (eye worm) hypothetical protein 0.0113 0.0834 0.0907
Leishmania major protein kinase, putative 0.0115 0.0849 0.3395
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0374 0.1515
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0673 0.2724
Loa Loa (eye worm) hypothetical protein 0.0066 0.0208 0.0225
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0101 0.0673 0.0634
Giardia lamblia Kinase, NEK 0.0107 0.0751 0.2834
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.1084 0.2112
Plasmodium falciparum casein kinase 1 0.0085 0.0464 0.3656
Trichomonas vaginalis AGC family protein kinase 0.0237 0.2471 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0668 0.0725
Echinococcus multilocularis tyrosine kinase 0.0083 0.0437 0.0533
Schistosoma mansoni tyrosine kinase 0.0207 0.2071 0.4036
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0079 0.0382 0.2623
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0055 0.0065 0.0023
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0121 0.0929 0.101
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0509 0.0993
Loa Loa (eye worm) hypothetical protein 0.0081 0.0398 0.0432
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0089 0.0509 0.4234
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0374 0.1515
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0101 0.0673 0.2705
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0185 0.1787 0.1752
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0079 0.0382 0.0341
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0099 0.0645 0.2365
Echinococcus granulosus insulin receptor 0.0319 0.3556 0.3528
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0596 0.1161
Giardia lamblia Kinase, CMGC GSK 0.0101 0.0673 0.2435
Echinococcus multilocularis mitogen activated protein kinase 14 0.0125 0.0992 0.1209
Loa Loa (eye worm) hypothetical protein 0.0152 0.1342 0.146
Loa Loa (eye worm) TK/ABL protein kinase 0.0247 0.2607 0.2838
Trypanosoma cruzi casein kinase, putative 0.0085 0.0464 0.1674
Schistosoma mansoni kinase 0.0228 0.2347 0.4573
Brugia malayi probable protein kinase 0.0209 0.2098 0.2253
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0374 0.1515
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0266 0.0518
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0262 0.0511
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0781 0.316
Brugia malayi Cam kinase protein 1 0.0079 0.0382 0.0376
Echinococcus multilocularis death associated protein kinase 1 0.067 0.8201 1
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0262 0.0511
Toxoplasma gondii histone kinase SNF1, putative 0.007 0.0262 0.0398
Echinococcus granulosus dual specificity 0.0109 0.0781 0.0742
Loa Loa (eye worm) CDC7 protein kinase 0.0071 0.0266 0.0288
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0266 0.1077
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0085 0.0464 0.0503
Echinococcus multilocularis titin 0.0055 0.0063 0.0077
Loa Loa (eye worm) AUR protein kinase 0.0115 0.0849 0.0923
Trichomonas vaginalis AGC family protein kinase 0.0237 0.2471 1
Brugia malayi Fes/CIP4 homology domain containing protein 0.0092 0.0556 0.0566
Entamoeba histolytica protein kinase, putative 0.0132 0.1084 0.3277
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0323 0.3611 0.3584
Schistosoma mansoni atypical protein kinase C 0.0245 0.2573 0.5013
Schistosoma mansoni tyrosine kinase 0.0367 0.4189 0.8161
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0085 0.0464 0.1674
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0079 0.0382 0.0414
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0121 0.0934 0.3299
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0751 0.304
Echinococcus granulosus Vam6:Vps39 protein 0.0088 0.0501 0.0461
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0067 0.0213 0.0437
Onchocerca volvulus 0.0071 0.0266 0.0514
Trypanosoma brucei cdc2-related kinase 3 0.0094 0.057 0.1709
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0089 0.0509 0.1446
Schistosoma mansoni tyrosine kinase 0.0185 0.1787 0.3482
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.2154 0.4197
Trichomonas vaginalis AGC family protein kinase 0.0148 0.1298 0.5252
Schistosoma mansoni serine/threonine kinase 0.0171 0.1597 0.3111
Echinococcus granulosus ephrin type A receptor 4 A 0.0089 0.0508 0.0468
Echinococcus granulosus serine:threonine protein kinase N2 0.0102 0.0688 0.0649
Echinococcus granulosus cyclin dependent kinase 1 0.0094 0.057 0.053
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0196 0.0383
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0521 0.2108
Onchocerca volvulus 0.0155 0.1384 0.2688
Echinococcus multilocularis mitogen activated protein kinase 14 0.0125 0.0992 0.1209
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0382 0.0744
Onchocerca volvulus 0.0083 0.0437 0.0847
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0067 0.0213 0.0643
Schistosoma mansoni protein kinase 0.0085 0.0464 0.0904
Giardia lamblia Kinase, CMGC CLK 0.0121 0.0934 0.3769
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0262 0.1062
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.057 0.2306
Plasmodium falciparum calcium-dependent protein kinase 1 0.0079 0.0382 0.2623
Brugia malayi Protein kinase domain containing protein 0.0083 0.0437 0.0437
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.017 0.1587 0.1935
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0199 0.1964 0.2138
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0437 0.0474
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.057 0.0619
Echinococcus granulosus STE20 serine:threonine protein kinase 0.039 0.4498 0.4475
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0129 0.1044 0.1272
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0089 0.0509 0.1899
Echinococcus multilocularis casein kinase I alpha 0.0085 0.0464 0.0565
Echinococcus multilocularis serine:threonine protein kinase 0.009 0.0521 0.0635
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0185 0.1787 0.2179
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.04
Schistosoma mansoni hypothetical protein 0.0088 0.0501 0.0976
Echinococcus granulosus tyrosine protein kinase Fyn 0.0185 0.1787 0.1752
Echinococcus granulosus activin receptor type 0.0064 0.0178 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.207 0.4033
Loa Loa (eye worm) AGC/PKA protein kinase 0.0089 0.0509 0.0553
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.057 0.1723
Echinococcus granulosus protein kinase c iota type 0.024 0.2509 0.2478
Echinococcus granulosus tyrosine protein kinase Src42A 0.0116 0.0872 0.0834
Plasmodium vivax protein kinase Crk2 0.0094 0.057 0.4998
Echinococcus multilocularis calcium activated potassium channel 0.0106 0.0738 0.0899
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0079 0.0382 0.0341
Brugia malayi hypothetical protein 0.0088 0.0501 0.0506
Plasmodium vivax serine/threonine kinase-1, putative 0.0121 0.0934 0.9605
Echinococcus multilocularis rac serine:threonine kinase 0.013 0.1059 0.1291
Echinococcus granulosus tyrosine protein kinase HCK 0.0108 0.0758 0.0719
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0781 0.316
Giardia lamblia Kinase, STE STE20 0.0068 0.0227 0.0155
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0101 0.0673 0.2506
Echinococcus granulosus casein kinase ii subunit alpha 0.0079 0.0374 0.0334
Onchocerca volvulus 0.0101 0.0673 0.1305
Trichomonas vaginalis CK1 family protein kinase 0.0085 0.0464 0.1877
Trichomonas vaginalis STE family protein kinase 0.0068 0.0227 0.0918
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0673 0.2035
Brugia malayi Tyrosine-protein kinase abl-1 0.0101 0.0672 0.0694
Entamoeba histolytica PH domain containing protein kinase, putative 0.013 0.1059 0.3202
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0089 0.0509 0.0469
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.009 0.0521 0.0566
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0119 0.0905 0.0984
Echinococcus multilocularis serine:threonine protein kinase 0.009 0.0521 0.0635
Toxoplasma gondii aurora kinase 0.0115 0.0849 0.3062
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0179 0.0726
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0146 0.1271 0.1348
Echinococcus multilocularis dual specificity protein kinase clk2 0.0121 0.0934 0.1139
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0531 0.2149
Echinococcus granulosus protein kinase C gamma type 0.0165 0.1512 0.1476
Loa Loa (eye worm) hypothetical protein 0.009 0.0521 0.0566
Plasmodium falciparum calcium-dependent protein kinase 3 0.0079 0.0382 0.2623
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0123 0.0965 0.4145

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9 nM BindingDB_Patents: kinase Assay. The final concentration of DMSO is 5%. 10 µL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 mM Tris-HCl pH 7.5, 0.1 mM EDTA, 0.1 mM EGTA, 0.286 mM sodium orthovanadate, 10% glycerol, 1 mg/mL bovine serum albumin, 1 mM dithiothreitol) and the mixture is incubated for 24 h at RT under with shaking. The kinase reaction is started by the addition of 20 µL ATP solution [final concentration: 250 µM ATP, 30 mM Tris-HCl pH 7.5, 0.02% Brij, 0.2 mM sodium orthovanadate, 10 mM magnesium acetate, 0.1 mM EGTA, phosphatase cocktail (Sigma, # P2850, dilution recommended by the manufacturer), 0.1 mM EGTA] and 10 µL MEK1 solution [containing 50 ng biotinylated MEK1 (prepared from purified MEK1 according to standard procedure, e.g. with EZ-Link Sulpho-NHS-LC-Biotin reagent, Pierce, #21335) and carried out for 60 min at RT with constant shaking. ChEMBL. No reference
IC50 (binding) = 9 nM kinase Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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