Detailed information for compound 223126

Basic information

Technical information
  • TDR Targets ID: 223126
  • Name: 4-(2,4-dichloroanilino)-6-methoxy-7-(3-morpho lin-4-ylpropoxy)quinoline-3-carbonitrile
  • MW: 487.378 | Formula: C24H24Cl2N4O3
  • H donors: 1 H acceptors: 2 LogP: 5.22 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1OCCCN1CCOCC1)ncc(c2Nc1ccc(cc1Cl)Cl)C#N
  • InChi: 1S/C24H24Cl2N4O3/c1-31-22-12-18-21(13-23(22)33-8-2-5-30-6-9-32-10-7-30)28-15-16(14-27)24(18)29-20-4-3-17(25)11-19(20)26/h3-4,11-13,15H,2,5-10H2,1H3,(H,28,29)
  • InChiKey: BRHLUELBKABILP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(2,4-dichloroanilino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile
  • 4-(2,4-dichloroanilino)-6-methoxy-7-(3-morpholinopropoxy)-3-quinolinecarbonitrile
  • 4-[(2,4-dichlorophenyl)amino]-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrile
  • 4-[(2,4-dichlorophenyl)amino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile
  • 4-[(2,4-dichlorophenyl)amino]-6-methoxy-7-(3-morpholinopropoxy)-3-quinolinecarbonitrile
  • 4-Phenylamino-3-quinolinecarbonitrile deriv. 25

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens FYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.002 0.0216
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0066 0.0338 0.0491
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0072 0.0104
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0171 0.1849
Brugia malayi Ets-domain containing protein 0.0085 0.0466 0.0675
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0287 0.0287
Plasmodium falciparum DNA repair protein REV1, putative 0.003 0.0095 0.1309
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Echinococcus granulosus neuropeptide FF receptor 2 0.0151 0.091 0.091
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0155 0.0933 0.1353
Echinococcus multilocularis aldehyde reductase 0.0047 0.0211 0.0211
Brugia malayi Matrixin family protein 0.0127 0.0747 0.1083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0066 0.0338 0.0491
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0288 0.0417
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0104 0.0104
Schistosoma mansoni thyroid hormone receptor 0.0191 0.1176 0.1176
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0179 0.0259
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.002 0.0276
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Echinococcus granulosus sex peptide receptor 0.0151 0.091 0.091
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0462 0.2993 0.2993
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.002 0.002
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0043 0.0187 0.2333
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0924 0.4848
Loa Loa (eye worm) G-protein coupled receptor 0.0151 0.091 0.1319
Mycobacterium ulcerans lipase LipD 0.0042 0.0179 0.0211
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0171 0.2135
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Trypanosoma cruzi DNA polymerase kappa, putative 0.0153 0.0924 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0032 0.0352
Echinococcus multilocularis Smad4 0.0019 0.0025 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0131 0.0773 0.0773
Onchocerca volvulus Protein ultraspiracle homolog 0.0066 0.0338 0.0464
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.019 0.0245
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Schistosoma mansoni opsin-like receptor 0.0151 0.091 0.091
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0019 0.0024 0.0031
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.002 0.0008
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0084 0.0461 0.0571
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0024 0.0024
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.0164 0.0238
Schistosoma mansoni retinoic acid receptor RXR 0.0066 0.0338 0.0338
Brugia malayi Sex muscle abnormal protein 5 0.0018 0.0016 0.0023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0311 0.0311
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0734 0.0734
Loa Loa (eye worm) histone methyltransferase 0.0024 0.0057 0.0082
Onchocerca volvulus 0.0042 0.0179 0.0229
Echinococcus multilocularis neuropeptide Y receptor 0.0151 0.091 0.091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.013 0.013
Plasmodium falciparum histone acetyltransferase GCN5 0.0124 0.0725 1
Echinococcus granulosus aldo keto reductase 0.0066 0.0339 0.0339
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0066 0.0339 0.0339
Schistosoma mansoni hypothetical protein 0.03 0.1906 0.1906
Mycobacterium ulcerans hypothetical protein 0.0019 0.0024 0.0014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0293 0.1535
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0381 0.0381
Schistosoma mansoni tyrosine kinase 0.0091 0.0506 0.0506
Schistosoma mansoni neuroligin 3 (S09 family) 0.0084 0.0461 0.0461
Brugia malayi conserved hypotetical protein 0.0031 0.0104 0.0151
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0127 0.0747 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.019 0.0245
Brugia malayi CHE-14 protein 0.005 0.0228 0.0331
Onchocerca volvulus 0.0151 0.091 0.1308
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0066 0.0339 0.0339
Echinococcus multilocularis G-protein coupled receptor, putative 0.0151 0.091 0.091
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0072 0.0776
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.004 0.0164 0.2265
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.019 0.0245
Echinococcus granulosus tyrosine protein kinase Blk 0.0082 0.0446 0.0446
Echinococcus multilocularis growth factor receptor bound protein 2 0.0018 0.0016 0.0016
Echinococcus multilocularis Protein lozenge 0.0121 0.0709 0.0709
Loa Loa (eye worm) carboxylesterase 0.0498 0.324 0.4696
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus 7tm_1 domain containing protein 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Loa Loa (eye worm) hypothetical protein 0.0155 0.0933 0.1353
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.002 0.002
Echinococcus multilocularis g protein coupled receptor 0.0151 0.091 0.091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0338 0.0338
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0117 0.0683 0.0683
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.091 0.091
Schistosoma mansoni amine GPCR 0.0151 0.091 0.091
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0091 0.0506 0.0506
Schistosoma mansoni peroxidasin 0.0029 0.0088 0.0088
Schistosoma mansoni Smad4 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0287 0.1823 0.2642
Schistosoma mansoni blooms syndrome DNA helicase 0.0049 0.0222 0.0222
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0104 0.0104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.002 0.0029
Loa Loa (eye worm) neuropeptide F receptor 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0066 0.0338 0.0338
Brugia malayi Melatonin receptor type 1A 0.0151 0.091 0.1319
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0019 0.0024 0.0035
Brugia malayi Matrixin family protein 0.0127 0.0747 0.1083
Onchocerca volvulus 0.0066 0.0339 0.0465
Schistosoma mansoni thyroid hormone receptor 0.0191 0.1176 0.1176
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0179 0.0179
Brugia malayi MH2 domain containing protein 0.0282 0.1789 0.2593
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0019 0.0024 0.0035
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0095 0.0498
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0096 0.0538 0.0779
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Trypanosoma brucei DNA polymerase IV, putative 0.0153 0.0924 0.4848
Brugia malayi beta-lactamase 0.0042 0.0179 0.0259
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0179 0.0211
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0104 0.0104
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.011 0.0633 0.0791
Echinococcus granulosus g protein coupled receptor 0.0151 0.091 0.091
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0924 0.4848
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0091 0.0506 0.0506
Echinococcus multilocularis NCK adaptor protein 0.0018 0.0016 0.0016
Onchocerca volvulus 0.0131 0.0773 0.1106
Schistosoma mansoni hypothetical protein 0.0048 0.0216 0.0216
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0104 0.0104
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0262 0.0333
Plasmodium vivax hypothetical protein, conserved 0.0044 0.019 0.2375
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0381 0.0468
Schistosoma mansoni steroid hormone receptor ad4bp 0.0066 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Onchocerca volvulus 0.0151 0.091 0.1308
Loa Loa (eye worm) matrix metalloproteinase 0.0127 0.0747 0.1083
Echinococcus multilocularis expressed conserved protein 0.0108 0.0624 0.0624
Trypanosoma cruzi metacaspase, putative 0.0044 0.019 0.2057
Leishmania major prostaglandin f synthase, putative 0.0066 0.0339 0.5357
Echinococcus granulosus dnaJ subfamily B 0.0886 0.5837 0.5837
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0066 0.0338 0.0338
Trichomonas vaginalis set domain proteins, putative 0.1028 0.6796 1
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.007 0.007
Echinococcus multilocularis g protein coupled receptor 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Schistosoma mansoni biogenic amine receptor 0.0151 0.091 0.091
Mycobacterium tuberculosis Conserved protein 0.0042 0.0179 0.0211
Echinococcus multilocularis neuropeptide receptor A26 0.0151 0.091 0.091
Brugia malayi G-protein coupled receptor 0.0151 0.091 0.1319
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0104 0.0151
Giardia lamblia DINP protein human, muc B family 0.011 0.0633 0.1214
Loa Loa (eye worm) steroid hormone receptor 0.0066 0.0338 0.0491
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0091 0.0506 0.0506
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0151 0.091 0.091
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0104 0.0104
Mycobacterium tuberculosis Conserved protein 0.0042 0.0179 0.0211
Onchocerca volvulus 0.0151 0.091 0.1308
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.002 0.0027 0.0341
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0072 0.0104
Echinococcus granulosus caspase 8 0.0044 0.019 0.019
Schistosoma mansoni smad1 5 8 and 0.0019 0.0025 0.0025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0084 0.0461 0.0461
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0151 0.091 0.091
Trypanosoma cruzi DNA damage repair protein, putative 0.003 0.0095 0.1027
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0055 0.008
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0151 0.091 0.091
Schistosoma mansoni hypothetical protein 0.0151 0.091 0.091
Onchocerca volvulus 0.0967 0.6381 0.9388
Loa Loa (eye worm) hypothetical protein 0.0084 0.0461 0.0668
Trypanosoma brucei aldo/keto reductase, putative 0.0019 0.0024 0.0127
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.0164 0.0238
Onchocerca volvulus 0.0066 0.0338 0.0464
Echinococcus multilocularis neuropeptide Y receptor 0.0151 0.091 0.091
Brugia malayi Carboxylesterase family protein 0.0084 0.0461 0.0668
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0691 0.453 0.6655
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0338 0.0338
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0337 0.216 0.2738
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0104 0.0104
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Plasmodium falciparum flap endonuclease 1 0.0062 0.0309 0.4258
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0066 0.0338 0.0338
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Schistosoma mansoni tyrosine kinase 0.0091 0.0506 0.0506
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0066 0.0339 0.0339
Echinococcus granulosus 7TM GPCR rhodopsin 0.0151 0.091 0.091
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.002 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0066 0.0338 0.0491
Brugia malayi Matrixin family protein 0.0307 0.1955 0.2834
Echinococcus granulosus bloom syndrome protein 0.0069 0.0358 0.0358
Schistosoma mansoni opsin-like receptor 0.0151 0.091 0.091
Treponema pallidum fructose-bisphosphate aldolase 0.0691 0.453 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0151 0.091 0.1319
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0104 0.0151
Schistosoma mansoni hypothetical protein 0.018 0.1103 0.1103
Brugia malayi larval opioid receptor 0.0151 0.091 0.1319
Echinococcus multilocularis tyrosine protein kinase Abl 0.0021 0.0033 0.0033
Mycobacterium ulcerans oxidoreductase 0.0066 0.0339 0.0416
Brugia malayi Cytochrome P450 family protein 0.0026 0.0072 0.0104
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0151 0.091 0.091
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0171 0.1849
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0381 0.0381
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0151 0.091 0.091
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0293 0.0396
Schistosoma mansoni opsin-like receptor 0.0151 0.091 0.091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0381 0.0468
Schistosoma mansoni hypothetical protein 0.0042 0.0179 0.0179
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0151 0.091 0.091
Echinococcus multilocularis thyroid hormone receptor alpha 0.0191 0.1176 0.1176
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0293 0.0293
Trypanosoma brucei DNA polymerase eta, putative 0.0096 0.0538 0.2821
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0104 0.0104
Echinococcus granulosus alpha 1A adrenergic receptor 0.0151 0.091 0.091
Leishmania major DNA polymerase kappa, putative 0.003 0.0095 0.1498
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0458 0.2971 0.2971
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.005 0.0228 0.0331
Echinococcus multilocularis 0.0018 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0041 0.017 0.017
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0019 0.0024 0.0302
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0088 0.0127
Loa Loa (eye worm) matrixin family protein 0.0307 0.1955 0.2834
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0179 0.0259
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0135 0.08 0.1146
Onchocerca volvulus 0.0151 0.091 0.1308
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1186 0.7852 1
Plasmodium falciparum metacaspase 1 0.0044 0.019 0.2622
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0338 0.0491
Brugia malayi polk-prov protein 0.0087 0.0481 0.0698
Echinococcus granulosus acetylcholinesterase 0.0498 0.324 0.324
Brugia malayi MH2 domain containing protein 0.0019 0.0025 0.0036
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0088 0.0127
Echinococcus granulosus tyrosine protein kinase Src42A 0.008 0.0429 0.0429
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0088 0.0127
Schistosoma mansoni DNA polymerase eta 0.0096 0.0538 0.0538
Echinococcus multilocularis caspase 3 0.0072 0.038 0.038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0179 0.0211
Trypanosoma brucei metacaspase MCA3 0.0044 0.019 0.0997
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0338 0.0491
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0151 0.091 0.091
Toxoplasma gondii aldose reductase, putative 0.0066 0.0339 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0924 0.4848
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0104 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0434 0.2279
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Schistosoma mansoni hypothetical protein 0.004 0.0164 0.0164
Loa Loa (eye worm) oxidoreductase 0.0066 0.0339 0.0492
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0691 0.453 0.6655
Leishmania major DNA polymerase eta, putative 0.0096 0.0538 0.8487
Brugia malayi jmjC domain containing protein 0.0062 0.0311 0.0451
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0088 0.0127
Onchocerca volvulus 0.0031 0.0104 0.0119
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0151 0.091 0.091
Schistosoma mansoni cytochrome P450 0.0018 0.0013 0.0013
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.0031 0.0031
Echinococcus multilocularis geminin 0.0199 0.1229 0.1229
Echinococcus multilocularis sex peptide receptor 0.0151 0.091 0.091
Onchocerca volvulus 0.0066 0.0339 0.0465
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0072 0.0074
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.019 0.0245
Schistosoma mansoni tyrosine kinase 0.0021 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.002
Brugia malayi Carboxylesterase family protein 0.0498 0.324 0.4696
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0151 0.091 0.091
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0104 0.0104
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0016 0.0016
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.006 0.006
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Echinococcus multilocularis tyrosine protein kinase HCK 0.0073 0.0385 0.0385
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0288 0.0417
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0169 0.1027 0.1489
Brugia malayi ecdysone receptor 0.0031 0.0104 0.0151
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0082 0.0446 0.0446
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.004 0.0164 0.0164
Schistosoma mansoni nuclear receptor 0.0031 0.0104 0.0104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0338 0.0491
Mycobacterium tuberculosis Conserved hypothetical protein 0.0096 0.0538 0.0669
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.002
Echinococcus granulosus aldo keto reductase 0.0066 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Brugia malayi Blistered cuticle protein 3 0.0029 0.0088 0.0127
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0151 0.091 0.091
Schistosoma mansoni adenoreceptor 0.0151 0.091 0.091
Loa Loa (eye worm) melatonin receptor type 1A 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Onchocerca volvulus Chorion peroxidase homolog 0.0029 0.0088 0.0094
Brugia malayi Matrixin family protein 0.0127 0.0747 0.1083
Echinococcus multilocularis aldo keto reductase 0.0066 0.0339 0.0339
Echinococcus granulosus allatostatin A receptor 0.0151 0.091 0.091
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0204 0.1072
Onchocerca volvulus Matrilysin homolog 0.0127 0.0747 0.1068
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0434 0.2279
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0179 0.0229
Brugia malayi Carboxylesterase family protein 0.0498 0.324 0.4696
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0311 0.0311
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.0016 0.0023
Schistosoma mansoni amine GPCR 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0091 0.0506 0.0506
Schistosoma mansoni nuclear hormone receptor 0.0066 0.0338 0.0338
Schistosoma mansoni growth hormone secretagogue receptor 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0087 0.0481 0.0698
Brugia malayi Dopamine receptor protein 2 0.0151 0.091 0.1319
Schistosoma mansoni gliotactin 0.0084 0.0461 0.0461
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.002 0.0105
Plasmodium vivax SET domain protein, putative 0.0131 0.0773 0.9663
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0337 0.216 0.2738
Brugia malayi Hemopexin family protein 0.018 0.1103 0.1599
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0204 0.3226
Entamoeba histolytica recQ family helicase, putative 0.0046 0.0204 0.04
Echinococcus granulosus ATP dependent DNA helicase Q5 0.004 0.0164 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0066 0.0338 0.0491
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1186 0.7852 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.0812 0.0812
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0066 0.0339 0.0492
Echinococcus granulosus geminin 0.0199 0.1229 0.1229
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0151 0.091 0.1319
Brugia malayi MH2 domain containing protein 0.0019 0.0025 0.0036
Schistosoma mansoni neuropeptide F-like receptor 0.0151 0.091 0.091
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0171 0.0217
Echinococcus multilocularis neuropeptides capa receptor 0.0151 0.091 0.091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0773 0.0773
Echinococcus multilocularis neuroligin 0.0084 0.0461 0.0461
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0095 0.0498
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0066 0.0338 0.0491
Echinococcus granulosus g protein coupled receptor 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0066 0.0338 0.0491
Echinococcus granulosus neuropeptide receptor 0.0151 0.091 0.091
Brugia malayi ORL1-like opioid receptor 0.0151 0.091 0.1319
Schistosoma mansoni lozenge 0.0121 0.0709 0.0709
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0434 0.2279
Loa Loa (eye worm) hypothetical protein 0.0287 0.1823 0.2642
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0153 0.0924 0.1329
Echinococcus multilocularis BC026374 protein (S09 family) 0.0084 0.0461 0.0461
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.017 0.017
Echinococcus granulosus flap endonuclease 1 0.0062 0.0309 0.0309
Loa Loa (eye worm) acetylcholinesterase 1 0.0498 0.324 0.4696
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.091 0.091
Loa Loa (eye worm) TK protein kinase 0.0073 0.0385 0.0558
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0151 0.091 0.091
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0135 0.08 1
Brugia malayi NADH-dependent xylose reductase 0.0019 0.0024 0.0035
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0262 0.3272
Echinococcus multilocularis aldo keto reductase 0.0066 0.0339 0.0339
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0151 0.091 0.1319
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.0671 0.0671
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.091 0.091
Schistosoma mansoni hypothetical protein 0.0048 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.004 0.0164 0.0238
Echinococcus multilocularis allatostatin A receptor 0.0151 0.091 0.091
Echinococcus granulosus neuropeptides capa receptor 0.0151 0.091 0.091
Brugia malayi Muscleblind-like protein 0.0175 0.1071 0.1553
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0924 0.4848
Trypanosoma brucei DNA polymerase IV, putative 0.0153 0.0924 0.4848
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0691 0.453 0.6655
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0164 0.0238
Brugia malayi hypothetical protein 0.0035 0.013 0.0188
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0179 0.0229
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.007 0.007
Onchocerca volvulus 0.0066 0.0339 0.0465
Loa Loa (eye worm) hypothetical protein 0.0066 0.0338 0.0491
Loa Loa (eye worm) hypothetical protein 0.0042 0.0179 0.0259
Brugia malayi Tyrosine-protein kinase abl-1 0.0021 0.0033 0.0048
Onchocerca volvulus Peroxidase homolog 0.0029 0.0088 0.0094
Echinococcus granulosus ATP dependent DNA helicase Q1 0.004 0.0164 0.0164
Echinococcus granulosus histone acetyltransferase KAT2B 0.0135 0.08 0.08
Brugia malayi AKH receptor 0.0151 0.091 0.1319
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0013 0.0145
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0262 0.1374
Echinococcus granulosus neuroligin 0.0084 0.0461 0.0461
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0066 0.0338 0.0338
Echinococcus multilocularis cpg binding protein 0.0066 0.0337 0.0337
Echinococcus granulosus orexin receptor type 2 0.0151 0.091 0.091
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0151 0.091 0.1308
Onchocerca volvulus 0.0084 0.0461 0.0645
Mycobacterium tuberculosis Probable oxidoreductase 0.0066 0.0339 0.0416
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0151 0.091 0.091
Leishmania major cytochrome p450-like protein 0.0018 0.0013 0.0211
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0104 0.0104
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.019 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.091 0.091
Loa Loa (eye worm) fli-1 protein 0.0258 0.1626 0.2357
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0066 0.0338 0.0464
Echinococcus multilocularis transcription factor btf3 0.0041 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.091 0.091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0066 0.0338 0.0491
Echinococcus granulosus histone lysine methyltransferase setb 0.0131 0.0773 0.0773
Trypanosoma brucei DNA polymerase IV, putative 0.0139 0.0828 0.4345
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Schistosoma mansoni hypothetical protein 0.0024 0.006 0.006
Echinococcus granulosus tm gpcr rhodopsin 0.0151 0.091 0.091
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0025 0.0025
Echinococcus granulosus growth factor receptor bound protein 2 0.0018 0.0016 0.0016
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Trichomonas vaginalis esterase, putative 0.0042 0.0179 0.0229
Loa Loa (eye worm) hypothetical protein 0.0967 0.6381 0.925
Brugia malayi steroid hormone receptor 0.0066 0.0338 0.0491
Brugia malayi G protein-coupled receptor F59B2.13 0.0151 0.091 0.1319
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.002 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0924 0.4848
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0066 0.0338 0.0338
Toxoplasma gondii histone lysine methyltransferase SET1 0.0134 0.0793 0.101
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.013 0.0188
Schistosoma mansoni smad1 5 8 and 0.0019 0.0025 0.0025
Schistosoma mansoni potassium channel beta 0.0019 0.0024 0.0024
Brugia malayi nuclear receptor NHR-88 0.0031 0.0104 0.0151
Leishmania major hypothetical protein, conserved 0.0055 0.0262 0.4132
Plasmodium falciparum aldo-keto reductase, putative 0.0019 0.0024 0.0333
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0091 0.0506 0.0506
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0293 0.0396
Brugia malayi RE15519p 0.0151 0.091 0.1319
Brugia malayi beta-lactamase family protein 0.0042 0.0179 0.0259
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0096 0.0538 0.0538
Echinococcus granulosus Smad4 0.0019 0.0025 0.0025
Echinococcus multilocularis aldo keto reductase 0.0066 0.0339 0.0339
Trichomonas vaginalis aldo/keto reductase, putative 0.0066 0.0339 0.0465
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0084 0.0461 0.0461
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0062 0.0309 0.1619
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0293 0.4036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0125 0.0732 0.0732
Onchocerca volvulus 0.0151 0.091 0.1308
Echinococcus multilocularis g-protein coupled receptor 0.0151 0.091 0.091
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0262 0.3612
Loa Loa (eye worm) hypothetical protein 0.1044 0.6898 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0066 0.0339 0.0339
Echinococcus granulosus ecdysone induced protein 78C 0.0066 0.0338 0.0338
Onchocerca volvulus 0.0151 0.091 0.1308
Schistosoma mansoni biogenic amine (5HT) receptor 0.0151 0.091 0.091
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0057 0.0057
Toxoplasma gondii NAC domain-containing protein 0.0041 0.0171 0.0218
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0062 0.0309 0.4871
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0381 0.0468
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0016 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0031 0.0031
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0179 0.0939
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.0671 0.0671
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0691 0.453 0.6655
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Loa Loa (eye worm) carboxylesterase 0.0084 0.0461 0.0668
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0104 0.0119
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0179 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.091 0.091
Schistosoma mansoni nck2/grb4 0.0018 0.0016 0.0016
Echinococcus granulosus tyrosine protein kinase Fyn 0.0091 0.0506 0.0506
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.002 0.002
Toxoplasma gondii exonuclease III APE 0.0059 0.0293 0.0373
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0091 0.0506 0.0506
Brugia malayi Latrophilin receptor protein 2 0.0019 0.002 0.0029
Echinococcus granulosus tyrosine protein kinase Src42A 0.0091 0.0506 0.0506
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0293 0.0356
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0179 0.1937
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0262 0.3612
Schistosoma mansoni hypothetical protein 0.0199 0.1229 0.1229
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0179 0.0179
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0021 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0151 0.091 0.091
Giardia lamblia Sgs1 DNA helicase, putative 0.004 0.0164 0.0156
Entamoeba histolytica protein kinase, putative 0.0073 0.0385 0.0801
Echinococcus granulosus carboxylesterase 5A 0.0498 0.324 0.324
Brugia malayi Smad1 0.0019 0.0025 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0066 0.0338 0.0491
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0091 0.0506 0.0506
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0417
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0072 0.0776
Schistosoma mansoni ap endonuclease 0.0059 0.0293 0.0293
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Giardia lamblia Histone acetyltransferase GCN5 0.0124 0.0725 0.142
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus tm gpcr rhodopsin 0.0151 0.091 0.091
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0164 0.0209
Trypanosoma cruzi DNA polymerase eta, putative 0.0096 0.0538 0.5819
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus g-protein coupled receptor 0.0151 0.091 0.091
Schistosoma mansoni microtubule-associated protein tau 0.1506 1 1
Onchocerca volvulus 0.0084 0.0461 0.0645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0066 0.0338 0.0491
Brugia malayi nuclear hormone receptor 0.0031 0.0104 0.0151
Brugia malayi hypothetical protein 0.0041 0.017 0.0246
Echinococcus multilocularis flap endonuclease 1 0.0062 0.0309 0.0309
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0151 0.091 0.1319
Brugia malayi Carboxylesterase family protein 0.0084 0.0461 0.0668
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0904 0.5959 0.8639
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Onchocerca volvulus 0.0041 0.017 0.0215
Leishmania major cytochrome p450-like protein 0.0018 0.0013 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.019 0.0245
Echinococcus multilocularis para nitrobenzyl esterase 0.0084 0.0461 0.0461
Brugia malayi ImpB/MucB/SamB family protein 0.0096 0.0538 0.0779
Echinococcus multilocularis fmrfamide receptor 0.0151 0.091 0.091
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.002 0.0025
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.019 0.2057
Plasmodium falciparum aldehyde reductase, putative 0.0019 0.0024 0.0333
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Mycobacterium leprae Probable lipase LipE 0.0042 0.0179 0.0211
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0151 0.091 0.091
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0691 0.453 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0044 0.019 0.0275
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0088 0.0127
Entamoeba histolytica recQ family helicase, putative 0.002 0.0027 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0171 0.0217
Echinococcus granulosus dna polymerase kappa 0.0153 0.0924 0.0924
Brugia malayi Cytochrome P450 family protein 0.0018 0.0013 0.0019
Brugia malayi nuclear receptor NHR-88 0.0066 0.0338 0.0491
Trypanosoma brucei prostaglandin f synthase 0.0066 0.0339 0.1781
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.0188
Toxoplasma gondii pantoate-beta-alanine ligase 0.1186 0.7852 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0179 0.0229
Echinococcus multilocularis tyrosine protein kinase Src42A 0.008 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.004 0.0164 0.0238
Schistosoma mansoni hypothetical protein 0.0048 0.0216 0.0216
Loa Loa (eye worm) blistered cuticle protein 3 0.0029 0.0088 0.0127
Brugia malayi neuropeptide F receptor 0.0151 0.091 0.1319
Schistosoma mansoni biogenic amine (5HT) receptor 0.0287 0.1823 0.1823
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Mycobacterium ulcerans beta-lactamase 0.0042 0.0179 0.0211
Onchocerca volvulus 0.0029 0.0088 0.0094
Loa Loa (eye worm) hypothetical protein 0.0042 0.0179 0.0259
Toxoplasma gondii ABC1 family protein 0.0042 0.0179 0.0228
Echinococcus multilocularis caspase 2 0.0085 0.0464 0.0464
Loa Loa (eye worm) SRC-1 0.0091 0.0506 0.0733
Mycobacterium ulcerans DNA polymerase IV 0.0153 0.0924 0.1162
Schistosoma mansoni smad 0.0019 0.0025 0.0025
Loa Loa (eye worm) runx1 0.0121 0.0709 0.1028
Giardia lamblia Fructose-bisphosphate aldolase 0.0691 0.453 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Echinococcus granulosus caspase 2 0.0085 0.0464 0.0464
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0032 0.0026
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0179 0.0211
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0151 0.091 0.1319
Brugia malayi G protein-coupled receptor 0.0151 0.091 0.1319
Brugia malayi Matrixin family protein 0.0127 0.0747 0.1083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.091 0.091
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.002 0.025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Echinococcus granulosus hypothetical protein 0.0151 0.091 0.091
Brugia malayi putative neuropeptide receptor NPR1 0.0151 0.091 0.1319
Echinococcus granulosus G protein coupled receptor 139 0.0151 0.091 0.091
Brugia malayi hypothetical protein 0.0031 0.0104 0.0151
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0088 0.0094
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0151 0.091 0.091
Echinococcus granulosus tyrosine protein kinase Src64B 0.0091 0.0506 0.0506
Schistosoma mansoni coup transcription factor 0.0066 0.0338 0.0338
Loa Loa (eye worm) G-protein coupled receptor 0.0151 0.091 0.1319
Loa Loa (eye worm) TYRA-2 protein 0.0151 0.091 0.1319
Echinococcus granulosus biogenic amine 5HT receptor 0.0151 0.091 0.091
Toxoplasma gondii aldo-keto reductase 0.0019 0.0024 0.0031
Schistosoma mansoni caspase-7 (C14 family) 0.0116 0.0674 0.0674
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.1706 0.216
Echinococcus granulosus dro:myosuppressin receptor 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0179 0.0259
Onchocerca volvulus 0.0151 0.091 0.1308
Trypanosoma brucei metacaspase MCA2 0.0044 0.019 0.0997
Echinococcus multilocularis smad 0.0019 0.0025 0.0025
Onchocerca volvulus 0.0066 0.0339 0.0465
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0019 0.0024 0.0381
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0179 0.0211
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0062 0.0309 0.334
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.002 0.002
Onchocerca volvulus 0.0029 0.0088 0.0094
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0151 0.091 0.091
Brugia malayi nuclear receptor RXR 0.0031 0.0104 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.091 0.091
Echinococcus granulosus g protein coupled receptor 0.0151 0.091 0.091
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0019 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.019 0.0245
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0095 0.1027
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0066 0.0338 0.0491
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0293 0.0356
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Trichomonas vaginalis spcc417.12 protein, putative 0.0084 0.0461 0.0645
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0131 0.0773 0.0985
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0179 0.0179
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0381 0.0485
Onchocerca volvulus 0.0151 0.091 0.1308
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.019 0.0245
Brugia malayi Peroxidasin 0.0029 0.0088 0.0127
Echinococcus granulosus hypothetical protein 0.0066 0.0339 0.0339
Schistosoma mansoni alpha-1 adrenergic receptor 0.0151 0.091 0.091
Loa Loa (eye worm) oxidoreductase 0.0066 0.0339 0.0492
Schistosoma mansoni hypothetical protein 0.0151 0.091 0.091
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0091 0.0506 0.0506
Onchocerca volvulus 0.0151 0.091 0.1308
Brugia malayi Bloom's syndrome protein homolog 0.0069 0.0358 0.052
Echinococcus granulosus tyrosine kinase 0.0082 0.0446 0.0446
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0031 0.0031
Onchocerca volvulus 0.0151 0.091 0.1308
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0088 0.0127
Echinococcus multilocularis FTZ F1 alpha 0.0066 0.0338 0.0338
Echinococcus granulosus sterol regulatory element binding protein 0.005 0.0228 0.0228
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0024 0.0024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0179 0.0259
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0066 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0095 0.1027
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0293 0.0596
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.006 0.006
Plasmodium vivax SET domain containing protein 0.0017 0.0012 0.015
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0018 0.0016 0.0023
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0381 0.0468
Schistosoma mansoni nuclear receptor 0.0031 0.0104 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Onchocerca volvulus Cell death protein 3 homolog 0.0085 0.0464 0.065
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0151 0.091 0.091
Schistosoma mansoni BC026374 protein (S09 family) 0.0084 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0066 0.0338 0.0338
Brugia malayi photoreceptor-specific nuclear receptor 0.0066 0.0338 0.0491
Echinococcus multilocularis g protein coupled receptor 0.0151 0.091 0.091
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0104 0.0119
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0066 0.0339 0.0339
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0066 0.0339 0.0339
Brugia malayi MH1 domain containing protein 0.0019 0.0025 0.0036
Echinococcus multilocularis caspase 8 0.0044 0.019 0.019
Brugia malayi protein-tyrosine kinase 0.0082 0.0446 0.0647
Loa Loa (eye worm) hypothetical protein 0.0042 0.0179 0.0259
Schistosoma mansoni cpg binding protein 0.0066 0.0337 0.0337
Onchocerca volvulus 0.0151 0.091 0.1308
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0287 0.0287
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0066 0.0339 0.0492
Echinococcus multilocularis voltage gated potassium channel subunit 0.0019 0.0024 0.0024
Schistosoma mansoni DNA helicase recq1 0.004 0.0164 0.0164
Echinococcus granulosus histone acetyltransferase KAT2B 0.0446 0.2885 0.2885
Echinococcus multilocularis peroxidasin 0.0029 0.0088 0.0088
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0095 0.0121
Onchocerca volvulus 0.0062 0.0313 0.0426
Loa Loa (eye worm) RecQ helicase 0.0069 0.0358 0.052
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.013 0.0188
Loa Loa (eye worm) hypothetical protein 0.0084 0.0461 0.0668
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0293 0.3166
Echinococcus multilocularis Niemann Pick C1 protein 0.0165 0.1003 0.1003
Onchocerca volvulus 0.0031 0.0104 0.0119
Brugia malayi Serotonin receptor 0.0151 0.091 0.1319
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0924 0.4848
Brugia malayi hypothetical protein 0.0035 0.013 0.0188
Echinococcus granulosus neuropeptide receptor 0.0151 0.091 0.091
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0013 0.0211
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Brugia malayi ImpB/MucB/SamB family protein 0.0096 0.0538 0.0779
Brugia malayi hypothetical protein 0.0035 0.0132 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0691 0.453 0.6655
Brugia malayi Cytochrome P450 family protein 0.0055 0.0267 0.0388
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Echinococcus multilocularis acetylcholinesterase 0.0498 0.324 0.324
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0023
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0104 0.0151
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0066 0.0339 0.0465
Schistosoma mansoni terminal deoxycytidyl transferase 0.0096 0.0538 0.0538
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.019 0.0245
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.002 0.0025
Schistosoma mansoni pol-related 0.0066 0.0339 0.0339
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0013 0.0145
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0204 0.2212
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0151 0.091 0.091
Leishmania major hypothetical protein, conserved 0.0042 0.0179 0.2826
Onchocerca volvulus 0.0151 0.091 0.1308
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0104 0.0104
Echinococcus multilocularis muscleblind protein 1 0.0175 0.1071 0.1071
Trichomonas vaginalis aldo/keto reductase, putative 0.0066 0.0339 0.0465
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Echinococcus multilocularis tyrosine protein kinase Srms 0.0082 0.0446 0.0446
Brugia malayi cytochrome P450 0.0018 0.0013 0.0019
Brugia malayi hypothetical protein 0.0029 0.0088 0.0127
Brugia malayi Serotonin receptor 0.0151 0.091 0.1319
Schistosoma mansoni amine GPCR 0.0151 0.091 0.091
Brugia malayi CXXC zinc finger family protein 0.0062 0.0313 0.0453
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.1186 0.7852 1
Brugia malayi sulfakinin receptor protein 0.0151 0.091 0.1319
Echinococcus multilocularis ecdysone induced protein 78C 0.0066 0.0338 0.0338
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0116 0.0674 0.0674
Leishmania major metacaspase, putative 0.0044 0.019 0.3
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.0671 0.1434
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Trypanosoma brucei DNA damage repair protein, putative 0.003 0.0095 0.0498
Schistosoma mansoni adapter molecule crk 0.0018 0.0016 0.0016
Plasmodium vivax flap endonuclease 1, putative 0.0062 0.0309 0.3857
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0115 0.0671 0.0972
Schistosoma mansoni patched 1 0.005 0.0228 0.0228
Trypanosoma brucei metacaspase 0.0044 0.019 0.0997
Loa Loa (eye worm) matrixin family protein 0.0282 0.1785 0.2587
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Trichomonas vaginalis bromodomain-containing protein, putative 0.0135 0.08 0.1146
Loa Loa (eye worm) hypothetical protein 0.0066 0.0338 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0338 0.0491
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0338 0.0338
Brugia malayi Isocitrate dehydrogenase 0.0019 0.002 0.0029
Brugia malayi nuclear receptor RXR 0.0035 0.013 0.0188
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0151 0.091 0.091
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0095 0.1027
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.0188
Echinococcus granulosus somatostatin receptor 0.0151 0.091 0.091
Leishmania major DNA polymerase kappa, putative 0.011 0.0633 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0267 0.0388
Loa Loa (eye worm) neuropeptide F receptor 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Brugia malayi GnHR receptor homolog 0.0151 0.091 0.1319
Echinococcus granulosus para nitrobenzyl esterase 0.0084 0.0461 0.0461
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0066 0.0338 0.0338
Schistosoma mansoni neuropeptide f receptor 76f 0.0151 0.091 0.091
Echinococcus multilocularis microtubule associated protein 2 0.1506 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0021 0.0033 0.0033
Loa Loa (eye worm) Smad1 0.0019 0.0025 0.0036
Trypanosoma cruzi aldo-keto reductase 0.0066 0.0339 0.3673
Schistosoma mansoni neuropeptide receptor 0.0151 0.091 0.091
Schistosoma mansoni amine GPCR 0.0151 0.091 0.091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0338 0.0491
Schistosoma mansoni biogenic amine receptor 0.0151 0.091 0.091
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0088 0.0127
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0104 0.0104
Entamoeba histolytica Flap nuclease, putative 0.0062 0.0309 0.0631
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0066 0.0339 0.5357
Echinococcus multilocularis aldo keto reductase 0.0066 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0044 0.019 0.0275
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0313 0.0453
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0151 0.091 0.091
Giardia lamblia Aldose reductase 0.0066 0.0339 0.0551
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0091 0.0506 0.0506
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0044 0.019 0.019
Schistosoma mansoni hypothetical protein 0.0151 0.091 0.091
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0293 0.3166
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0179 0.0229
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0104 0.0151
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.0343
Echinococcus granulosus muscleblind protein 0.0175 0.1071 0.1071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0032 0.0041
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.0671 0.0972
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.091 0.091
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.091 0.091
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0262 0.2833
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.002 0.0315
Schistosoma mansoni acetylcholinesterase 0.0084 0.0461 0.0461
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Schistosoma mansoni aldo-keto reductase 0.0066 0.0339 0.0339
Plasmodium vivax aldehyde reductase, putative 0.0019 0.0024 0.0302
Plasmodium falciparum metacaspase-like protein 0.0044 0.019 0.2622
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0013 0.0017
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0066 0.0339 0.5357
Brugia malayi nuclear receptor NHR-67 0.0031 0.0104 0.0151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0179 0.0179
Echinococcus multilocularis dna polymerase kappa 0.0153 0.0924 0.0924
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Schistosoma mansoni amine GPCR 0.0151 0.091 0.091
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0021 0.0033 0.0033
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0179 0.0179
Echinococcus multilocularis dnaJ subfamily B 0.0886 0.5837 0.5837
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0066 0.0338 0.0491
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0381 0.0381
Echinococcus granulosus serotonin receptor 0.0151 0.091 0.091
Onchocerca volvulus 0.0029 0.0088 0.0094
Loa Loa (eye worm) flap endonuclease-1 0.0062 0.0309 0.0447
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0135 0.08 0.1019
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0151 0.091 0.1319
Trichomonas vaginalis DNA helicase recq1, putative 0.0069 0.0358 0.0494
Echinococcus multilocularis muscleblind protein 0.0175 0.1071 0.1071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.002 0.002
Echinococcus multilocularis serotonin receptor 0.0287 0.1823 0.1823
Brugia malayi Flap endonuclease-1 0.0062 0.0309 0.0447
Trypanosoma cruzi aldo/keto reductase, putative 0.0066 0.0339 0.3673
Trypanosoma brucei aldo-keto reductase, putative 0.0066 0.0339 0.1781
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0084 0.0461 0.0461
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0066 0.0338 0.0338
Onchocerca volvulus 0.0084 0.0461 0.0645
Brugia malayi G-protein coupled receptor 0.0151 0.091 0.1319
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0337 0.216 0.2738
Echinococcus multilocularis caspase 0.0116 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus NCK adaptor protein 0.0018 0.0016 0.0016
Brugia malayi hypothetical protein 0.0031 0.0104 0.0151
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0151 0.091 0.1319
Trypanosoma brucei Metacaspase-4 0.0044 0.019 0.0997
Loa Loa (eye worm) hypothetical protein 0.0066 0.0338 0.0491
Loa Loa (eye worm) hypothetical protein 0.0127 0.0747 0.1083
Onchocerca volvulus 0.0151 0.091 0.1308
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0025 0.0025
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0088 0.0127
Onchocerca volvulus 0.0084 0.0461 0.0645
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0151 0.091 0.1319
Echinococcus granulosus peroxidasin 0.0029 0.0088 0.0088
Onchocerca volvulus 0.0151 0.091 0.1308
Trypanosoma cruzi metacaspase, putative 0.0044 0.019 0.2057
Mycobacterium ulcerans carboxylesterase, LipT 0.0084 0.0461 0.0571
Entamoeba histolytica aldose reductase, putative 0.0066 0.0339 0.0699
Entamoeba histolytica recQ family DNA helicase 0.002 0.0032 0.0019
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0032 0.0352
Loa Loa (eye worm) hypothetical protein 0.0175 0.1071 0.1553
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.019 0.2057
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0066 0.0339 0.0492
Mycobacterium ulcerans hypothetical protein 0.0042 0.0179 0.0211
Echinococcus multilocularis neuropeptide FF receptor 2 0.0151 0.091 0.091
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Schistosoma mansoni neuropeptide receptor 0.0151 0.091 0.091
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0199 0.1229 0.1229
Schistosoma mansoni zinc finger protein 0.0031 0.0104 0.0104
Echinococcus multilocularis acetylcholinesterase 0.0498 0.324 0.324
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus transcription factor btf3 0.0041 0.0171 0.0171
Schistosoma mansoni aldo-keto reductase 0.0066 0.0339 0.0339
Brugia malayi tailless protein 0.0031 0.0104 0.0151
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.0343
Echinococcus granulosus smad 0.0019 0.0025 0.0025
Trypanosoma brucei unspecified product 0.0066 0.0338 0.1776
Entamoeba histolytica transcription factor BTF3, putative 0.0041 0.0171 0.0325
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0204 0.0266
Brugia malayi nuclear hormone receptor 0.0066 0.0338 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0481 0.2525
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0088 0.0094
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0293 0.5
Leishmania major DNA damage repair protein, putative 0.003 0.0095 0.1498
Echinococcus granulosus caspase 0.0116 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.005 0.0228 0.0331
Schistosoma mansoni cpg binding protein 0.0062 0.0313 0.0313
Trypanosoma brucei chrX additional, unordered contigs 0.003 0.0095 0.0498
Trichomonas vaginalis flap endonuclease-1, putative 0.0062 0.0309 0.042
Loa Loa (eye worm) hypothetical protein 0.0084 0.0461 0.0668
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0021 0.0009
Schistosoma mansoni ap endonuclease 0.0059 0.0293 0.0293
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0013 0.0145
Echinococcus multilocularis GPCR, family 2 0.0019 0.002 0.002
Mycobacterium leprae Conserved hypothetical protein 0.0047 0.0211 0.0252
Echinococcus granulosus biogenic amine 5HT receptor 0.0287 0.1823 0.1823
Trypanosoma cruzi DNA damage repair protein, putative 0.003 0.0095 0.1027
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.007 0.007
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0084 0.0461 0.0645
Plasmodium vivax metacaspase 1, putative 0.0044 0.019 0.2375
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0151 0.091 0.091
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0016 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.091 0.091
Onchocerca volvulus 0.0066 0.0339 0.0465
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.002 0.002
Onchocerca volvulus 0.0066 0.0339 0.0465
Echinococcus granulosus tyrosine protein kinase HCK 0.0073 0.0385 0.0385
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0086 0.0474 0.0474
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Onchocerca volvulus Neuropeptide F receptor homolog 0.0151 0.091 0.1308
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0155 0.0933 0.1173
Loa Loa (eye worm) hypothetical protein 0.0127 0.0747 0.1083
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0131 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0096 0.0538 0.0779
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.0343
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0338 0.0338
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0066 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0066 0.0338 0.0491
Echinococcus multilocularis c src tyrosine kinase 0.0021 0.0033 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0151 0.091 0.091
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0066 0.0338 0.0338
Echinococcus multilocularis somatostatin receptor 0.0151 0.091 0.091
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0287 0.0287
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0151 0.091 0.091
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0066 0.0339 0.0492
Trypanosoma brucei transcription factor BTF3, putative 0.0041 0.0171 0.0896
Echinococcus granulosus Protein patched homolog 1 0.005 0.0228 0.0228
Schistosoma mansoni biogenic amine receptor 0.0151 0.091 0.091
Echinococcus multilocularis fmrfamide receptor 0.0151 0.091 0.091
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0171 0.0217
Loa Loa (eye worm) hypothetical protein 0.0085 0.0464 0.0673
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus neuropeptide Y receptor 0.0151 0.091 0.091
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0066 0.0338 0.0491
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0151 0.091 0.1319
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0025 0.0036
Echinococcus multilocularis G protein coupled receptor 139 0.0151 0.091 0.091
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0066 0.0339 0.0339
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.002 0.002
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0013 0.007
Loa Loa (eye worm) hypothetical protein 0.0175 0.1071 0.1553
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.002 0.0216
Schistosoma mansoni DNA helicase recq5 0.004 0.0164 0.0164
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0096 0.0538 0.0538
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.013 0.013
Schistosoma mansoni histamine h1 receptor 0.0151 0.091 0.091
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0498 0.324 0.324
Schistosoma mansoni tyrosine kinase 0.0021 0.0033 0.0033
Trypanosoma brucei metacaspase 5, putative 0.0044 0.019 0.0997
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0025 0.0036
Schistosoma mansoni neuropeptide receptor 0.0151 0.091 0.091
Mycobacterium leprae Possible oxidoreductase 0.0019 0.0024 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0153 0.0924 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0461 0.0668
Brugia malayi Fli-1 protein 0.0258 0.1626 0.2357
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.0188
Loa Loa (eye worm) hypothetical protein 0.0055 0.0262 0.0379
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0151 0.091 0.091
Loa Loa (eye worm) transcription factor SMAD2 0.0282 0.1789 0.2593
Onchocerca volvulus 0.1028 0.6796 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0063 0.0318 0.4392
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.0031 0.0031
Echinococcus granulosus GPCR family 2 0.0019 0.002 0.002
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.004 0.0164 0.0164
Echinococcus granulosus GA binding protein alpha chain 0.0085 0.0466 0.0466
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.019 0.0245
Echinococcus multilocularis dro:myosuppressin receptor 0.0151 0.091 0.091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0338 0.0491
Loa Loa (eye worm) MH2 domain-containing protein 0.0282 0.1789 0.2593
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0287 0.0287
Loa Loa (eye worm) carboxylesterase 0.0084 0.0461 0.0668
Schistosoma mansoni peroxidasin 0.0029 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0066 0.0338 0.0491
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0293 0.4617
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Schistosoma mansoni neuropeptide receptor 0.0151 0.091 0.091
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0032 0.0032
Onchocerca volvulus Bile acid receptor homolog 0.0066 0.0338 0.0464
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0691 0.453 0.6655
Brugia malayi hypothetical protein 0.0151 0.091 0.1319
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.019 0.0245
Brugia malayi MH1 domain containing protein 0.0019 0.0025 0.0036
Echinococcus multilocularis sterol regulatory element binding protein 0.005 0.0228 0.0228
Echinococcus multilocularis protein dispatched 1 0.0057 0.0275 0.0275
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0131 0.0773 0.0773
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.019 0.0245
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Brugia malayi hypothetical protein 0.0084 0.0461 0.0668
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0066 0.0339 0.0465
Onchocerca volvulus Matrilysin homolog 0.0282 0.1785 0.26
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.091 0.091
Brugia malayi Cell death protein 3 precursor 0.0085 0.0464 0.0673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.091 0.091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0179 0.0179
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.019 0.0245
Entamoeba histolytica hypothetical protein 0.0041 0.0171 0.0325
Onchocerca volvulus 0.0042 0.0179 0.0229
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0104 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.091 0.091
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0293 0.0424
Echinococcus granulosus neuropeptide Y receptor 0.0151 0.091 0.091
Trypanosoma cruzi aldo/keto reductase, putative 0.0019 0.0024 0.0261
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.002 0.002
Brugia malayi putative neuropeptide receptor 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Echinococcus granulosus tm gpcr rhodopsin 0.0151 0.091 0.091
Echinococcus granulosus caspase 3 0.0072 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0498 0.324 0.4696
Brugia malayi Pre-SET motif family protein 0.0131 0.0773 0.1121
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0293 0.0293
Mycobacterium leprae PROBABLE HYDROLASE 0.0155 0.0933 0.1173
Mycobacterium ulcerans hypothetical protein 0.003 0.0095 0.0104
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0151 0.091 0.091
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0016 0.0023
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0179 0.0211
Echinococcus granulosus tyrosine protein kinase Lyn 0.0091 0.0506 0.0506
Loa Loa (eye worm) cytochrome P450 0.0018 0.0013 0.0019
Brugia malayi Pre-SET motif family protein 0.0904 0.5959 0.8639
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0066 0.0338 0.0491
Brugia malayi isocitrate dehydrogenase 0.0019 0.002 0.0029
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0179 0.0211
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0179 0.2237
Loa Loa (eye worm) hypothetical protein 0.0498 0.324 0.4696
Schistosoma mansoni ets-related 0.0258 0.1626 0.1626
Brugia malayi beta-lactamase family protein 0.0042 0.0179 0.0259
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0151 0.091 0.091
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0691 0.453 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0886 0.5837 0.5837
Brugia malayi Dopamine receptor 0.0151 0.091 0.1319
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0151 0.091 0.1319
Entamoeba histolytica acetyltransferase, GNAT family 0.0124 0.0725 0.1555
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0085 0.0466 0.0675
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Trypanosoma cruzi DNA polymerase kappa, putative 0.0153 0.0924 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0151 0.091 0.091
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0104 0.0151
Loa Loa (eye worm) hypothetical protein 0.0084 0.0461 0.0668
Loa Loa (eye worm) hypothetical protein 0.0061 0.0303 0.0439
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus granulosus voltage gated potassium channel subunit 0.0019 0.0024 0.0024
Leishmania major cytochrome p450-like protein 0.0026 0.0072 0.1132
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0091 0.0506 0.0506
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0262 0.2833
Trichomonas vaginalis DNA polymerase eta, putative 0.0153 0.0924 0.1329
Onchocerca volvulus Matrix metalloproteinase homolog 0.0282 0.1785 0.26
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0924 0.4848
Echinococcus granulosus BC026374 protein S09 family 0.0084 0.0461 0.0461
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0066 0.0339 0.0416
Echinococcus multilocularis serotonin receptor 0.0287 0.1823 0.1823
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0179 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0179 0.1937
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0066 0.0338 0.0338
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0116 0.0674 0.0674
Echinococcus multilocularis GA binding protein alpha chain 0.0085 0.0466 0.0466
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.091 0.091
Loa Loa (eye worm) DR-78 0.0031 0.0104 0.0151
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) acetyltransferase 0.0458 0.2971 0.4307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0066 0.0338 0.0491
Onchocerca volvulus 0.0127 0.0747 0.1068
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0073 0.0383 0.0555
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0057 0.0057
Schistosoma mansoni smad1 5 8 and 0.0019 0.0025 0.0025
Echinococcus granulosus tyrosine protein kinase Fyn 0.0091 0.0506 0.0506
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0151 0.091 0.091
Echinococcus granulosus tachykinin peptides receptor 99D 0.0151 0.091 0.091
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0293 0.0424
Trypanosoma brucei DNA damage repair protein, putative 0.003 0.0095 0.0498
Mycobacterium tuberculosis Conserved protein 0.0019 0.0024 0.0014
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0127 0.0747 0.1083
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0293 0.3656
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0072 0.0104
Echinococcus granulosus dna polymerase eta 0.0096 0.0538 0.0538
Schistosoma mansoni transcription factor btf3 0.0041 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.091 0.091
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.091 0.091
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0084 0.0461 0.0571
Echinococcus granulosus FTZ F1 alpha 0.0066 0.0338 0.0338
Loa Loa (eye worm) beta-lactamase 0.0042 0.0179 0.0259
Echinococcus granulosus cpg binding protein 0.0066 0.0337 0.0337
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0171 0.0248
Echinococcus multilocularis bloom syndrome protein 0.0069 0.0358 0.0358
Loa Loa (eye worm) oxidoreductase 0.0066 0.0339 0.0492
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0151 0.091 0.091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0084 0.0461 0.0668
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0179 0.0211
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0031 0.0031
Echinococcus multilocularis neuropeptide receptor 0.0151 0.091 0.091
Onchocerca volvulus 0.0151 0.091 0.1308
Echinococcus granulosus fmrfamide receptor 0.0151 0.091 0.091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Schistosoma mansoni flap endonuclease-1 0.0056 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0967 0.6381 0.925
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0084 0.0461 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.019 0.0245
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0088 0.0127
Echinococcus granulosus tyrosine protein kinase Fyn 0.0091 0.0506 0.0506
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0104 0.0104
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0104 0.0104
Loa Loa (eye worm) ATP-dependent DNA helicase 0.004 0.0164 0.0238
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0066 0.0339 0.0339
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0084 0.0461 0.0461
Mycobacterium ulcerans hydrolase 0.0155 0.0933 0.1173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.091 0.091
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0481 0.2525
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Schistosoma mansoni hypothetical protein 0.0125 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.0246
Brugia malayi Carboxylesterase family protein 0.0084 0.0461 0.0668
Leishmania major basic transcription factor 3a, putative 0.0041 0.0171 0.2696
Echinococcus multilocularis neuropeptide receptor 0.0151 0.091 0.091
Echinococcus multilocularis neuropeptide s receptor 0.0151 0.091 0.091
Echinococcus multilocularis protein patched 0.005 0.0228 0.0228
Trichomonas vaginalis DNA helicase recq, putative 0.0069 0.0358 0.0494
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0164 0.0209
Brugia malayi acetyltransferase, GNAT family protein 0.0458 0.2971 0.4307
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0458 0.2971 0.2971
Brugia malayi follicle stimulating hormone receptor 0.0151 0.091 0.1319
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.013 0.0188
Loa Loa (eye worm) oxidoreductase 0.0066 0.0339 0.0492
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.019 0.0242
Onchocerca volvulus Dual oxidase homolog 0.0029 0.0088 0.0094
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0293 0.0446
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.091 0.091
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.017 0.017
Echinococcus multilocularis tyrosine protein kinase Blk 0.0082 0.0446 0.0446
Brugia malayi hypothetical protein 0.0042 0.0179 0.0259
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.0338 0.0491
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.019 0.0242
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Chlamydia trachomatis glutamine binding protein 0.0019 0.0021 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0151 0.091 0.091
Mycobacterium ulcerans DNA polymerase IV 0.0153 0.0924 0.1162
Echinococcus granulosus aldo keto reductase 0.0066 0.0339 0.0339
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0135 0.08 0.1019
Trichomonas vaginalis aldo/keto reductase, putative 0.0066 0.0339 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0066 0.0338 0.0491
Trypanosoma cruzi metacaspase, putative 0.0044 0.019 0.2057
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0082 0.0446 0.0446
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0633 0.3324
Onchocerca volvulus 0.0151 0.091 0.1308
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.0188
Loa Loa (eye worm) oxidoreductase 0.0066 0.0339 0.0492
Echinococcus granulosus acetylcholinesterase 0.0498 0.324 0.324
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0044 0.0191 0.0243
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.091 0.091
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0104 0.0151
Echinococcus multilocularis neuropeptides capa receptor 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Schistosoma mansoni hypothetical protein 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0381 0.0381
Echinococcus granulosus expressed conserved protein 0.0108 0.0624 0.0624
Schistosoma mansoni myosin xvIII 0.0151 0.091 0.091
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0104 0.0151
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0104 0.0151
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.002 0.0029
Echinococcus granulosus c src tyrosine kinase 0.0021 0.0033 0.0033
Loa Loa (eye worm) TK protein kinase 0.0082 0.0446 0.0647
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0095 0.0121
Loa Loa (eye worm) hypothetical protein 0.0066 0.0338 0.0491
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0066 0.0338 0.0338
Brugia malayi beta-NAC-like protein 0.0041 0.0171 0.0248
Trypanosoma cruzi metacaspase, putative 0.0044 0.019 0.2057
Giardia lamblia Aldose reductase 0.0066 0.0339 0.0551
Onchocerca volvulus 0.0151 0.091 0.1308
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0179 0.0211
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0293 0.0602
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0228 0.0301
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Brugia malayi neuropeptide F receptor 0.0151 0.091 0.1319
Loa Loa (eye worm) hypothetical protein 0.0084 0.0461 0.0668
Onchocerca volvulus Peroxidase homolog 0.0029 0.0088 0.0094
Brugia malayi Dopamine receptor protein 1 0.1044 0.6898 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0179 0.0179
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0151 0.091 0.1319
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0096 0.0538 0.0538
Schistosoma mansoni cpg binding protein 0.0066 0.0337 0.0337
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.0188
Schistosoma mansoni caspase-3 (C14 family) 0.0116 0.0674 0.0674
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0019 0.0024 0.0031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0151
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0179 0.0211
Entamoeba histolytica aldose reductase, putative 0.0066 0.0339 0.0699
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0311 0.0311
Schistosoma mansoni caspase-7 (C14 family) 0.0085 0.0464 0.0464
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0151 0.091 0.1319
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0066 0.0338 0.0338
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0381 0.6007
Echinococcus granulosus neuropeptide s receptor 0.0151 0.091 0.091
Brugia malayi SRC-1 0.0091 0.0506 0.0733
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0066 0.0338 0.0338
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0066 0.0339 0.0492
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0181 0.0231
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0171 0.2357
Brugia malayi Ets-domain containing protein 0.0085 0.0466 0.0675
Brugia malayi Steroid receptor seven-up type 2 0.0066 0.0338 0.0491
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0025 0.0025
Echinococcus granulosus aldehyde reductase 0.0047 0.0211 0.0211
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0066 0.0339 0.0339
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0025 0.0025
Entamoeba histolytica aldose reductase, putative 0.0066 0.0339 0.0699
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0072 0.0376
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.019 0.0242
Onchocerca volvulus 0.0042 0.0179 0.0229
Schistosoma mansoni DNA polymerase IV / kappa 0.003 0.0095 0.0095
Leishmania major aldo-keto reductase-like protein 0.0066 0.0339 0.5357
Brugia malayi jmjC domain containing protein 0.0058 0.0287 0.0416
Schistosoma mansoni neuropeptide F-like receptor 0.0151 0.091 0.091
Schistosoma mansoni gabp alpha 0.0085 0.0466 0.0466
Brugia malayi hypothetical protein 0.0055 0.0262 0.0379
Schistosoma mansoni RAR-like nuclear receptor 0.0066 0.0338 0.0338
Plasmodium vivax DNA repair protein REV1, putative 0.003 0.0095 0.1186
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0104 0.0151
Trypanosoma brucei RNA helicase, putative 0.03 0.1906 1
Onchocerca volvulus 0.018 0.1103 0.1594
Brugia malayi ecdysteroid receptor 0.0066 0.0338 0.0491
Echinococcus multilocularis carboxylesterase 5A 0.0498 0.324 0.324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.091 0.091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0066 0.0339 0.0339
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0462 0.2993 0.2993
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0288 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0773 0.0773
Echinococcus multilocularis dna polymerase eta 0.0096 0.0538 0.0538
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.011 0.0633 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0924 0.4848
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0691 0.453 0.6655
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0021 0.0009
Giardia lamblia Flap structure-specific endonuclease 0.0062 0.0309 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.019 0.0245
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0091 0.0506 0.0506
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0151 0.091 0.091
Brugia malayi Carboxylesterase family protein 0.0084 0.0461 0.0668
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.002
Trypanosoma brucei unspecified product 0.0066 0.0338 0.1776
Schistosoma mansoni hypothetical protein 0.0048 0.0216 0.0216
Echinococcus granulosus Niemann Pick C1 protein 0.0165 0.1003 0.1003
Loa Loa (eye worm) hypothetical protein 0.0131 0.0773 0.1121
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0311 0.0451
Brugia malayi Cytochrome P450 family protein 0.0026 0.0072 0.0104
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0066 0.0339 0.0465
Mycobacterium tuberculosis Conserved protein 0.0042 0.0179 0.0211
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.0343
Leishmania major DNA polymerase eta, putative 0.003 0.0095 0.1498
Echinococcus multilocularis orexin receptor type 2 0.0151 0.091 0.091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0179 0.0259
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0062 0.0309 0.0393
Echinococcus granulosus peptide allatostatin:somatostatin 0.0151 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0153 0.0924 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0339 0.0465
Echinococcus granulosus neuropeptides capa receptor 0.0151 0.091 0.091
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0924 0.4848
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0025 0.0025
Entamoeba histolytica deoxycytidyl transferase, putative 0.0096 0.0538 0.114
Trypanosoma brucei unspecified product 0.0139 0.0828 0.4345
Brugia malayi hypothetical protein 0.0967 0.6381 0.925
Loa Loa (eye worm) hypothetical protein 0.0066 0.0338 0.0491
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0021 0.0033 0.0033
Mycobacterium tuberculosis Carboxylesterase LipT 0.0084 0.0461 0.0571
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0691 0.453 0.6655
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0018 0.0016 0.0016
Onchocerca volvulus 0.0084 0.0461 0.0645
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0151 0.091 0.091

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.8 nM Inhibition against Src kinase ChEMBL. 11689083
IC50 (binding) = 3.8 nM Inhibitory activity against human c-Src Kinase was measured using ELISA assay ChEMBL. 11262092
IC50 (binding) = 3.8 nM Inhibition against Src kinase ChEMBL. 11689083
IC50 (binding) = 3.8 nM Inhibitory activity against human c-Src Kinase was measured using ELISA assay ChEMBL. 11262092
IC50 (functional) = 940 nM Ability to inhibit the proliferation of c-Src transformed rat fibroblasts growing in suspension ChEMBL. 11689083
IC50 (functional) = 0.94 uM Inhibition of Src-transformed rat fibroblast proliferation in anchorage independent assay ChEMBL. 11262092
IC50 (functional) = 0.94 uM Inhibition of Src-transformed rat fibroblast proliferation in anchorage independent assay ChEMBL. 11262092
IC50 (functional) = 3.2 uM Inhibition of Fyn-transformed rat fibroblast proliferation in anchorage independent assay ChEMBL. 11262092
IC50 (functional) = 3.2 uM Inhibition of Fyn-transformed rat fibroblast proliferation in anchorage independent assay ChEMBL. 11262092

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.