Detailed information for compound 23923

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.516 | Formula: C25H30N2O6
  • H donors: 3 H acceptors: 4 LogP: 1.62 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)/C=C\C(=O)N[C@@H]1CCC2(C34[C@H]1Oc1c4c(CC2N(CC3)CC2CC2)ccc1O)O
  • InChi: 1S/C25H30N2O6/c1-32-20(30)7-6-19(29)26-16-8-9-25(31)18-12-15-4-5-17(28)22-21(15)24(25,23(16)33-22)10-11-27(18)13-14-2-3-14/h4-7,14,16,18,23,28,31H,2-3,8-13H2,1H3,(H,26,29)/b7-6+/t16-,18?,23+,24?,25?/m1/s1
  • InChiKey: PQKHESYTSKMWFP-OEUAEKESSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major C-8 sterol isomerase-like protein 0.0662 0.1696 0.1675
Schistosoma mansoni biogenic amine receptor 0.026 0.0627 0.0627
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0059 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.015 0.0334 0.1877
Echinococcus multilocularis importin subunit beta 1 0.0064 0.0103 0.0103
Schistosoma mansoni chromobox protein 0.0069 0.0118 0.0118
Echinococcus granulosus laminin 0.0454 0.1142 0.1142
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Brugia malayi Cadherin domain containing protein 0.0214 0.0505 0.0505
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.015 0.0334 0.4095
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.026 0.0627 0.0627
Echinococcus multilocularis serotonin receptor 0.026 0.0627 0.0627
Echinococcus granulosus 7tm_1 domain containing protein 0.026 0.0627 0.0627
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0051 0.0577
Onchocerca volvulus 0.0047 0.0059 0.008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0219 0.0219
Brugia malayi larval opioid receptor 0.026 0.0627 0.0627
Brugia malayi EGF-like domain containing protein 0.0214 0.0505 0.0505
Onchocerca volvulus 0.0206 0.0483 0.078
Brugia malayi sulfakinin receptor protein 0.026 0.0627 0.0627
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.026 0.0627 0.0627
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0083 0.0082
Onchocerca volvulus 0.026 0.0627 0.1018
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0051 0.0051
Brugia malayi beta-lactamase 0.0107 0.0219 0.0219
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.026 0.0627 0.0627
Echinococcus multilocularis alpha 1A adrenergic receptor 0.026 0.0627 0.0627
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0279 0.0678 0.0662
Schistosoma mansoni transmemberane protein 0.0253 0.0608 0.0607
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.004 0.004
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0044 0.0051 0.0186
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0129 0.0278 0.0278
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0044 0.0051 0.0577
Schistosoma mansoni hypothetical protein 0.0214 0.0505 0.0504
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus granulosus biogenic amine 5HT receptor 0.026 0.0627 0.0627
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0253 0.0608 0.0607
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0045 0.0053 0.0042
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.026 0.0627 0.0627
Trypanosoma cruzi AMP deaminase, putative 0.0085 0.0161 0.0144
Loa Loa (eye worm) N-myristoyltransferase 2 0.3782 1 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0214 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.0107 0.0219 0.0219
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0073 0.0056
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0098 0.0098
Onchocerca volvulus 0.0206 0.0483 0.078
Mycobacterium ulcerans acyl-CoA synthetase 0.015 0.0334 0.4095
Echinococcus multilocularis neurogenic locus protein delta 0.0214 0.0505 0.0504
Echinococcus multilocularis snurportin 1 0.0678 0.1739 0.1738
Schistosoma mansoni hypothetical protein 0.0052 0.0071 0.0071
Echinococcus multilocularis fibropellin Ia 0.0214 0.0505 0.0504
Plasmodium falciparum M17 leucyl aminopeptidase 0.0103 0.0207 0.0196
Echinococcus granulosus neuropeptide receptor A26 0.026 0.0627 0.0627
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0051 0.0264
Plasmodium falciparum AMP deaminase, putative 0.0085 0.0161 0.0151
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.015 0.0334 0.4095
Trichomonas vaginalis glutaminase, putative 0.0318 0.0782 0.0775
Leishmania major calcium-transporting ATPase, putative 0.0049 0.0065 0.004
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0662 0.1696 0.1682
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0058 0.0048
Echinococcus multilocularis nervana 2 0.0253 0.0608 0.0607
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus granulosus neurogenic locus notch protein 0.0214 0.0505 0.0504
Onchocerca volvulus 0.0206 0.0483 0.078
Schistosoma mansoni hypothetical protein 0.0047 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0052 0.0073 0.0073
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0065 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.026 0.0627 0.0627
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0092 0.0092
Brugia malayi Cadherin domain containing protein 0.0214 0.0505 0.0505
Leishmania major hypothetical protein, conserved 0.0052 0.0073 0.0048
Echinococcus multilocularis neuropeptide Y receptor 0.026 0.0627 0.0627
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0303 0.074 0.074
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0085 0.0161 0.0144
Loa Loa (eye worm) hypothetical protein 0.0068 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.023 0.0545 0.0545
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0454 0.1142 0.1142
Loa Loa (eye worm) hypothetical protein 0.0177 0.0404 0.0404
Brugia malayi EGF-like domain containing protein 0.0214 0.0505 0.0505
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0219 0.0202
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0064 0.0064
Brugia malayi calpain family protein 1 0.0059 0.0091 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0216 0.1207
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0045 0.0038
Onchocerca volvulus Alhambra homolog 0.0029 0.0011 0.0001
Plasmodium vivax adenosine/AMP deaminase, putative 0.0085 0.0161 0.0151
Toxoplasma gondii AMP deaminase 0.0085 0.0161 0.0178
Schistosoma mansoni hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.004 0.004
Loa Loa (eye worm) G-protein coupled receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0107 0.0219 0.0219
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0253 0.0608 0.0607
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0097 0.0097
Brugia malayi PHD-finger family protein 0.0029 0.0011 0.0011
Plasmodium falciparum adenosine deaminase 0.0262 0.0632 0.0622
Brugia malayi Inositol-1 0.0045 0.0053 0.0053
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0068 0.0116 0.0116
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0045 0.0058
Echinococcus multilocularis chromobox protein 1 0.0069 0.0118 0.0118
Mycobacterium ulcerans fatty-acid-CoA ligase 0.015 0.0334 0.4095
Schistosoma mansoni neuropeptide F-like receptor 0.026 0.0627 0.0627
Toxoplasma gondii PAN domain-containing protein 0.3204 0.8461 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Brugia malayi GnHR receptor homolog 0.026 0.0627 0.0627
Trichomonas vaginalis cation-transporting ATPase, putative 0.0045 0.0053 0.0045
Onchocerca volvulus 0.0328 0.0807 0.1315
Onchocerca volvulus 0.0044 0.0051 0.0068
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0031 0.0017 0.0017
Brugia malayi AKH receptor 0.026 0.0627 0.0627
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0328 0.0807 0.0807
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0219 0.0219
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.2058 0.2057
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Brugia malayi Delta serrate ligand family protein 0.0214 0.0505 0.0505
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.031 0.076 0.076
Echinococcus multilocularis biogenic amine (5HT) receptor 0.026 0.0627 0.0627
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0303 0.074 0.0724
Trichomonas vaginalis N-myristoyl transferase, putative 0.2485 0.6548 0.6545
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0219 0.1223
Schistosoma mansoni hypothetical protein 0.0214 0.0505 0.0504
Brugia malayi mbt repeat family protein 0.0049 0.0064 0.0064
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0154 0.0343 0.0343
Echinococcus granulosus neuropeptides capa receptor 0.026 0.0627 0.0627
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0053 0.0595
Echinococcus granulosus glycoprotein Antigen 5 0.0328 0.0807 0.0807
Echinococcus multilocularis Tolloid protein 1 0.0454 0.1142 0.1142
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0684 0.1755 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0071 0.0064
Loa Loa (eye worm) hypothetical protein 0.2307 0.6073 0.6073
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.026 0.0627 0.0627
Echinococcus multilocularis chromobox protein 1 0.0069 0.0118 0.0118
Mycobacterium ulcerans lipase LipD 0.0107 0.0219 0.2668
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0044 0.0051 0.0034
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0253 0.0608 0.0607
Schistosoma mansoni biogenic amine (dopamine) receptor 0.026 0.0627 0.0627
Toxoplasma gondii microneme protein, putative 0.0206 0.0483 0.0559
Schistosoma mansoni hypothetical protein 0.0214 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.0454 0.1142 0.1142
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0328 0.0807 0.0807
Echinococcus granulosus neuropeptides capa receptor 0.026 0.0627 0.0627
Schistosoma mansoni opsin-like receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0039 0.0037 0.0037
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0097 0.0097
Trypanosoma brucei AMP deaminase, putative 0.0085 0.0161 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.0453 0.0452
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0051 0.0034
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0025 0.0025
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0103 0.0207 0.2817
Onchocerca volvulus 0.0206 0.0483 0.078
Onchocerca volvulus Matrilysin homolog 0.0038 0.0035 0.0042
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0206 0.0483 0.0559
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0219 0.2668
Brugia malayi EGF-like domain containing protein 0.0214 0.0505 0.0505
Plasmodium falciparum cysteine repeat modular protein 1 0.0303 0.074 0.073
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0219 0.0212
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0214 0.0505 0.0816
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0045 0.0053 0.0035
Toxoplasma gondii PAN/Apple domain-containing protein 0.0206 0.0483 0.0559
Toxoplasma gondii hypothetical protein 0.0206 0.0483 0.0559
Loa Loa (eye worm) hypothetical protein 0.0227 0.0539 0.0539
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0091 0.0091
Loa Loa (eye worm) AMP deaminase 0.0085 0.0161 0.0161
Echinococcus multilocularis rhodopsin orphan GPCR 0.026 0.0627 0.0627
Onchocerca volvulus 0.026 0.0627 0.1018
Loa Loa (eye worm) follicle stimulating hormone receptor 0.026 0.0627 0.0627
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0025 0.0008
Loa Loa (eye worm) hypothetical protein 0.0112 0.0233 0.0233
Trichomonas vaginalis set domain proteins, putative 0.0954 0.2474 0.2469
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0328 0.0807 0.0807
Onchocerca volvulus 0.0214 0.0505 0.0816
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0328 0.0807 0.0807
Toxoplasma gondii calcium binding egf domain-containing protein 0.0454 0.1142 0.1339
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0049 0.0065 0.0064
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0053 0.0036
Trichomonas vaginalis esterase, putative 0.0107 0.0219 0.0212
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0678 0.1739 0.1739
Echinococcus granulosus Na:K ATPase alpha subunit 0.0129 0.0278 0.0277
Echinococcus granulosus tm gpcr rhodopsin 0.026 0.0627 0.0627
Echinococcus multilocularis tumor protein p63 0.0679 0.174 0.174
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.0368 0.0368
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0051 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.023 0.023
Brugia malayi Dopamine receptor 0.026 0.0627 0.0627
Plasmodium falciparum acyl-CoA synthetase 0.0112 0.0233 0.0222
Brugia malayi RNA binding protein 0.0061 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0045 0.0053 0.0035
Schistosoma mansoni importin beta-1 0.0064 0.0103 0.0103
Brugia malayi Heterochromatin protein 1 0.0069 0.0118 0.0118
Brugia malayi EGF-like domain containing protein 0.0214 0.0505 0.0505
Mycobacterium ulcerans adenosine deaminase 0.0262 0.0632 0.7811
Trypanosoma cruzi AMP deaminase 2, putative 0.0085 0.0161 0.0144
Onchocerca volvulus 0.026 0.0627 0.1018
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Entamoeba histolytica hypothetical protein 0.0154 0.0343 0.0343
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0103 0.0207 0.019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.004 0.004
Onchocerca volvulus 0.0954 0.2474 0.4065
Echinococcus granulosus neurogenic locus protein delta 0.0214 0.0505 0.0504
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0044 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus granulosus protein jagged 1 0.0214 0.0505 0.0504
Echinococcus granulosus Protein patched homolog 1 0.0029 0.0012 0.0012
Onchocerca volvulus 0.026 0.0627 0.1018
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0035 0.0171
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0328 0.0807 0.0807
Schistosoma mansoni amine GPCR 0.026 0.0627 0.0627
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0328 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0177 0.0404 0.0404
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0025 0.0008
Schistosoma mansoni hypothetical protein 0.0028 0.0009 0.0009
Trichomonas vaginalis N-myristoyl transferase, putative 0.3782 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.015 0.0334 0.0309
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.0154 0.0343 0.0343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0453 0.0452
Loa Loa (eye worm) hypothetical protein 0.0328 0.0807 0.0807
Schistosoma mansoni rhodopsin-like orphan GPCR 0.026 0.0627 0.0627
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0031 0.0031
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0839 0.2166 0.2166
Entamoeba histolytica acyl-CoA synthetase, putative 0.015 0.0334 0.0334
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0049 0.0065 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.026 0.0627 0.0627
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0094 0.0185 0.8692
Echinococcus granulosus tissue type plasminogen activator 0.0303 0.074 0.0739
Mycobacterium leprae Probable lipase LipE 0.0107 0.0219 0.3024
Schistosoma mansoni neuropeptide F-like receptor 0.026 0.0627 0.0627
Trypanosoma brucei AMP deaminase, putative 0.0085 0.0161 0.0144
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Leishmania major GTP-binding protein, putative 0.0047 0.0058 0.0033
Echinococcus granulosus chromobox protein 1 0.0069 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0056 0.0083 0.0083
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0279 0.0678 0.0677
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0049 0.0065 0.0743
Brugia malayi Membrane calcium atpase protein 3 0.0049 0.0065 0.0065
Brugia malayi G protein-coupled receptor F59B2.13 0.026 0.0627 0.0627
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0085 0.0161 0.0144
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.026 0.0627 0.0627
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0107 0.0218 0.3006
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0045 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) RNA binding protein 0.0061 0.0097 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.0453 0.0452
Brugia malayi jmjC domain containing protein 0.0094 0.0185 0.0185
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0057 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0206 0.0483 0.0483
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.015 0.0334 0.1877
Schistosoma mansoni notch 0.0214 0.0505 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.031 0.076 0.0753
Schistosoma mansoni biogenic amine receptor 0.026 0.0627 0.0627
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0216 0.1207
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0049 0.0065 0.0064
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0049 0.0065 0.0064
Schistosoma mansoni hypothetical protein 0.0279 0.0678 0.0677
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.026 0.0627 0.0627
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0045 0.0053 0.0035
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0049 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0051 0.0044
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0025 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.0453 0.0452
Echinococcus granulosus tar DNA binding protein 0.0061 0.0097 0.0097
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0049 0.0065 0.0064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.004 0.0023
Onchocerca volvulus 0.026 0.0627 0.1018
Loa Loa (eye worm) PAN domain-containing protein 0.0206 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Brugia malayi RE15519p 0.026 0.0627 0.0627
Echinococcus granulosus rhodopsin orphan GPCR 0.026 0.0627 0.0627
Toxoplasma gondii microneme protein MIC17C 0.0206 0.0483 0.0559
Echinococcus granulosus alpha 1A adrenergic receptor 0.026 0.0627 0.0627
Brugia malayi Muscle positioning protein 4 0.0214 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0112 0.0233 0.0233
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.026 0.0627 0.1018
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0328 0.0807 0.0807
Onchocerca volvulus 0.015 0.0334 0.0534
Brugia malayi Importin beta-1 subunit 0.0064 0.0103 0.0103
Schistosoma mansoni N-myristoyltransferase 0.3782 1 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0044 0.0051 0.0264
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0049 0.0065 0.0065
Echinococcus multilocularis neuropeptide s receptor 0.026 0.0627 0.0627
Toxoplasma gondii PAN domain-containing protein 0.0206 0.0483 0.0559
Echinococcus multilocularis neuropeptides capa receptor 0.026 0.0627 0.0627
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0279 0.0678 0.0662
Loa Loa (eye worm) hypothetical protein 0.0206 0.0483 0.0483
Schistosoma mansoni cell polarity protein 0.0214 0.0505 0.0504
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0303 0.074 0.0717
Onchocerca volvulus 0.0214 0.0505 0.0816
Brugia malayi Cytochrome P450 family protein 0.0035 0.0027 0.0027
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0044 0.0051 0.0051
Trypanosoma brucei N-myristoyltransferase 0.3782 1 1
Leishmania major P-type ATPase, putative 0.0049 0.0065 0.004
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0053 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.026 0.0627 0.0627
Echinococcus granulosus neuropeptide s receptor 0.026 0.0627 0.0627
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.004 0.0023
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0071 0.0064
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.026 0.0627 0.0627
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.026 0.0627 0.0627
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0219 0.1223
Echinococcus multilocularis sex peptide receptor 0.026 0.0627 0.0627
Brugia malayi putative neuropeptide receptor NPR1 0.026 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.0111 0.023 0.023
Entamoeba histolytica AMP deaminase, putative 0.0085 0.0161 0.0161
Mycobacterium ulcerans acyl-CoA synthetase 0.015 0.0334 0.4095
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0253 0.0608 0.0607
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0085 0.0161 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.0453 0.0452
Trypanosoma cruzi hypothetical protein, conserved 0.0303 0.074 0.0724
Echinococcus granulosus neuropeptide Y receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0049 0.0066 0.0066
Schistosoma mansoni ATPase 0.0045 0.0053 0.0052
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0262 0.0632 0.0735
Onchocerca volvulus 0.0209 0.0491 0.0794
Loa Loa (eye worm) hypothetical protein 0.0262 0.0632 0.0632
Entamoeba histolytica adenosine deaminase, putative 0.0262 0.0632 0.0632
Onchocerca volvulus 0.0214 0.0505 0.0816
Loa Loa (eye worm) hypothetical protein 0.0112 0.0233 0.0233
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0049 0.0065 0.0064
Schistosoma mansoni calpain-7 (C02 family) 0.0029 0.0011 0.0011
Echinococcus multilocularis neurogenic locus notch protein 0.0214 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.0099 0.0198 0.0198
Schistosoma mansoni ap endonuclease 0.004 0.004 0.004
Loa Loa (eye worm) PAN domain-containing protein 0.0206 0.0483 0.0483
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0129 0.0278 0.0267
Schistosoma mansoni notch 0.0214 0.0505 0.0504
Onchocerca volvulus 0.0044 0.0051 0.0068
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0219 0.2668
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0303 0.074 0.073
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0129 0.0278 0.0277
Loa Loa (eye worm) hypothetical protein 0.0328 0.0807 0.0807
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0107 0.0106
Toxoplasma gondii HEAT repeat-containing protein 0.0064 0.0103 0.0109
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0103 0.0103
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0219 0.0202
Brugia malayi G-protein coupled receptor 0.026 0.0627 0.0627
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.026 0.0627 0.0627
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.026 0.0627 0.0627
Brugia malayi Trypsin family protein 0.0328 0.0807 0.0807
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0111 0.023 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0051 0.0264
Brugia malayi Augmenter of liver regeneration 0.0034 0.0025 0.0025
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Echinococcus multilocularis fat cadherin tumor suppressor 0.0214 0.0505 0.0504
Loa Loa (eye worm) glutaminase 0.0318 0.0782 0.0782
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Brugia malayi Dopamine receptor protein 2 0.026 0.0627 0.0627
Echinococcus multilocularis neurogenic locus protein delta 0.0214 0.0505 0.0504
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2307 0.6073 0.6073
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0025 0.0014
Onchocerca volvulus 0.0214 0.0505 0.0816
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0219 0.0212
Loa Loa (eye worm) G-protein coupled receptor 0.026 0.0627 0.0627
Toxoplasma gondii hypothetical protein 0.0206 0.0483 0.0559
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0062 0.01 0.0099
Echinococcus multilocularis neurogenic locus notch protein 0.0214 0.0505 0.0504
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0111 0.023 0.023
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0045 0.0053 0.0035
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0044 0.0051 0.0041
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0662 0.1696 0.1696
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0071 0.0071
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0058 0.0058
Echinococcus granulosus g protein coupled receptor 0.026 0.0627 0.0627
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0064 0.0064
Echinococcus multilocularis acetylcholinesterase 0.0134 0.0292 0.0292
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0209 0.0491 0.0491
Schistosoma mansoni notch 0.0214 0.0505 0.0504
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0262 0.0632 0.0735
Giardia lamblia High cysteine protein 0.0214 0.0505 0.0495
Entamoeba histolytica AMP deaminase, putative 0.0085 0.0161 0.0161
Loa Loa (eye worm) matrixin family protein 0.0041 0.0044 0.0044
Onchocerca volvulus 0.0206 0.0483 0.078
Onchocerca volvulus 0.0206 0.0483 0.078
Leishmania major importin beta-1 subunit, putative 0.0051 0.0071 0.0046
Schistosoma mansoni biogenic amine receptor 0.026 0.0627 0.0627
Echinococcus multilocularis neuropeptide receptor 0.026 0.0627 0.0627
Brugia malayi Serotonin receptor 0.026 0.0627 0.0627
Entamoeba histolytica hypothetical protein 0.0051 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.0015
Echinococcus granulosus transmembrane protease serine 3 0.0328 0.0807 0.0807
Echinococcus granulosus tumor protein p63 0.0679 0.174 0.174
Onchocerca volvulus 0.0132 0.0286 0.0455
Mycobacterium ulcerans beta-lactamase 0.0107 0.0219 0.2668
Echinococcus multilocularis microtubule associated protein 2 0.1371 0.3583 0.3582
Echinococcus granulosus slit 2 protein 0.0214 0.0505 0.0504
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0071 0.0054
Toxoplasma gondii peptidylprolyl isomerase 0.0303 0.074 0.0863
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Entamoeba histolytica Ran family GTPase 0.0047 0.0058 0.0058
Mycobacterium tuberculosis Conserved protein 0.0107 0.0219 0.1223
Loa Loa (eye worm) inositol-1 0.0045 0.0053 0.0053
Mycobacterium ulcerans glutaminase 0.0318 0.0782 0.9681
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.0368 0.0368
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.3782 1 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0064 0.009
Schistosoma mansoni adenosine deaminase 0.0262 0.0632 0.0631
Brugia malayi Kelch motif family protein 0.0113 0.0234 0.0234
Toxoplasma gondii kringle domain-containing protein 0.0303 0.074 0.0863
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0045 0.0053 0.0049
Schistosoma mansoni patched 1 0.0029 0.0012 0.0012
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.026 0.0627 0.0627
Echinococcus granulosus acetylcholinesterase 0.0134 0.0292 0.0292
Schistosoma mansoni chromobox protein 0.0069 0.0118 0.0118
Echinococcus granulosus peptide allatostatin:somatostatin 0.026 0.0627 0.0627
Brugia malayi CXXC zinc finger family protein 0.0029 0.001 0.001
Echinococcus multilocularis leucine aminopeptidase protein 0.0103 0.0207 0.0206
Toxoplasma gondii microneme protein MIC17B 0.0206 0.0483 0.0559
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.004 0.0023
Onchocerca volvulus 0.026 0.0627 0.1018
Trypanosoma cruzi AMP deaminase, putative 0.0085 0.0161 0.0144
Entamoeba histolytica hypothetical protein 0.0154 0.0343 0.0343
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0049 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0177 0.0404 0.0404
Plasmodium falciparum calcium-transporting ATPase 0.0049 0.0065 0.0054
Schistosoma mansoni hypothetical protein 0.0328 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0209 0.0491 0.0491
Leishmania major 4-coumarate:coa ligase-like protein 0.015 0.0334 0.0309
Loa Loa (eye worm) TYRA-2 protein 0.026 0.0627 0.0627
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0454 0.1142 0.1142
Echinococcus granulosus sex peptide receptor 0.026 0.0627 0.0627
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0194 0.0193
Onchocerca volvulus 0.0107 0.0219 0.0345
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0206 0.0483 0.0483
Echinococcus granulosus peregrin 0.0029 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0028 0.0009 0.0009
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0045 0.0053 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.026 0.0627 0.0627
Brugia malayi RNA, U transporter 1 0.0181 0.0415 0.0415
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0094 0.0185 0.0168
Echinococcus multilocularis neuropeptides capa receptor 0.026 0.0627 0.0627
Schistosoma mansoni glutaminase 0.0318 0.0782 0.0781
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0112 0.0233 0.13
Loa Loa (eye worm) hypothetical protein 0.0134 0.0292 0.0292
Onchocerca volvulus 0.026 0.0627 0.1018
Echinococcus granulosus importin subunit beta 1 0.0064 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.026 0.0627 0.0627
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0328 0.0807 0.0807
Loa Loa (eye worm) neuropeptide F receptor 0.026 0.0627 0.0627
Onchocerca volvulus 0.0206 0.0483 0.078
Echinococcus granulosus serotonin receptor 0.026 0.0627 0.0627
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0051 0.0044
Onchocerca volvulus Putative cubilin 0.0214 0.0505 0.0816
Schistosoma mansoni myosin xvIII 0.026 0.0627 0.0627
Onchocerca volvulus 0.0206 0.0483 0.078
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0129 0.0278 0.0277
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0037 0.0045
Echinococcus granulosus histone lysine methyltransferase setb 0.0121 0.0256 0.0255
Onchocerca volvulus 0.0303 0.074 0.1204
Brugia malayi CHE-14 protein 0.0029 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0028 0.0009 0.0009
Brugia malayi hypothetical protein 0.0154 0.0343 0.0343
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0545 0.0545
Loa Loa (eye worm) notch protein 0.0214 0.0505 0.0505
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0027 0.0027
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0328 0.0807 0.0807
Echinococcus multilocularis nervana 2 0.0209 0.0491 0.0491
Schistosoma mansoni neuropeptide receptor 0.026 0.0627 0.0627
Mycobacterium ulcerans hypothetical protein 0.0328 0.0807 1
Schistosoma mansoni cpg binding protein 0.003 0.0014 0.0014
Brugia malayi hypothetical protein 0.0328 0.0807 0.0807
Schistosoma mansoni rotamase 0.031 0.076 0.0759
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0031 0.0017 0.0017
Onchocerca volvulus 0.0206 0.0483 0.078
Echinococcus granulosus hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0107 0.0219 0.0219
Echinococcus granulosus neuropeptide Y receptor 0.026 0.0627 0.0627
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0073 0.0062
Brugia malayi EGF-like domain containing protein 0.0214 0.0505 0.0505
Echinococcus granulosus tm gpcr rhodopsin 0.026 0.0627 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.0678 0.0671
Onchocerca volvulus 0.0107 0.0219 0.0345
Loa Loa (eye worm) calpain family protein 1 0.0059 0.0091 0.0091
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Plasmodium vivax adenosine deaminase, putative 0.0262 0.0632 0.0622
Loa Loa (eye worm) hypothetical protein 0.0454 0.1142 0.1142
Echinococcus granulosus orexin receptor type 2 0.026 0.0627 0.0627
Mycobacterium tuberculosis Conserved protein 0.0107 0.0219 0.1223
Echinococcus multilocularis fibrillin 1 0.0454 0.1142 0.1142
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0049 0.0065 0.0048
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.004 0.0015
Echinococcus granulosus protein jagged 2 0.0214 0.0505 0.0504
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0328 0.0807 0.0807
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0262 0.0632 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0031 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0051 0.0577
Giardia lamblia CDC72 0.3782 1 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0256 0.0256
Onchocerca volvulus 0.026 0.0627 0.1018
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0049 0.0065 0.0048
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0071 0.0071
Onchocerca volvulus 0.0044 0.0051 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0031 0.0031
Onchocerca volvulus 0.0099 0.0198 0.0311
Plasmodium vivax acetyl-CoA synthetase, putative 0.0044 0.0051 0.0041
Echinococcus granulosus geminin 0.0876 0.2266 0.2266
Brugia malayi ORL1-like opioid receptor 0.026 0.0627 0.0627
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0256 0.0255
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0044 0.0051 0.0577
Brugia malayi Adenosine/AMP deaminase family protein 0.0262 0.0632 0.0632
Brugia malayi Protein kinase domain containing protein 0.0303 0.074 0.074
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.151 0.3954 0.3954
Echinococcus granulosus allatostatin A receptor 0.026 0.0627 0.0627
Brugia malayi adenosine monophosphate deaminase 0.0085 0.0161 0.0161
Brugia malayi GCC2 and GCC3 family protein 0.0214 0.0505 0.0505
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0071 0.0071
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0134 0.0292 0.0292
Entamoeba histolytica acyl-coA synthetase, putative 0.015 0.0334 0.0334
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0219 0.1223
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0045 0.0053 0.0053
Schistosoma mansoni slit 0.0214 0.0505 0.0504
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0219 0.0212
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0454 0.1142 0.1142
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0064 0.0064
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0011 0.0011
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.026 0.0627 0.0627
Echinococcus multilocularis g protein coupled receptor 0.026 0.0627 0.0627
Schistosoma mansoni inositol monophosphatase 0.0045 0.0053 0.0052
Echinococcus granulosus protein jagged 2 0.0214 0.0505 0.0504
Brugia malayi chromobox protein homolog 3 0.0039 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.015 0.0334 0.0334
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.026 0.0627 0.0627
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0194 0.0193
Onchocerca volvulus 0.0328 0.0807 0.1315
Onchocerca volvulus Slit protein homolog 0.0214 0.0505 0.0816
Schistosoma mansoni septate junction protein 0.0214 0.0505 0.0504
Onchocerca volvulus 0.0214 0.0505 0.0816
Loa Loa (eye worm) hypothetical protein 0.0113 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0454 0.1142 0.1142
Echinococcus granulosus integrin beta 2 0.0526 0.1334 0.1334
Echinococcus multilocularis transmembrane protease serine 3 0.0328 0.0807 0.0807
Echinococcus granulosus fibropellin Ia 0.0214 0.0505 0.0504
Toxoplasma gondii microneme protein MIC17A 0.0206 0.0483 0.0559
Brugia malayi Trypsin-like protease protein 5 0.0328 0.0807 0.0807
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.015 0.0334 0.0334
Schistosoma mansoni peptide (allatostatin)-like receptor 0.026 0.0627 0.0627
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0094 0.0185 0.0206
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0045 0.0053 0.0053
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0051 0.0051
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0044 0.0051 0.0577
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0195 0.0453 0.0453
Echinococcus granulosus protein jagged 1 0.0214 0.0505 0.0504
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Plasmodium vivax importin-beta 2, putative 0.0064 0.0103 0.0092
Loa Loa (eye worm) hypothetical protein 0.0037 0.0032 0.0032
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0058 0.0041
Schistosoma mansoni neuropeptide receptor 0.026 0.0627 0.0627
Toxoplasma gondii PAN domain-containing protein 0.0206 0.0483 0.0559
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0064 0.0064
Loa Loa (eye worm) MBCTL1 0.0056 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0154 0.0343 0.0343
Schistosoma mansoni integrin beta subunit 0.0413 0.1034 0.1033
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0049 0.0065 0.0054
Echinococcus multilocularis tissue type plasminogen activator 0.0303 0.074 0.0739
Onchocerca volvulus 0.0328 0.0807 0.1315
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0083 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.026 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.0678 0.1739 0.1738
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0049 0.0065 0.0065
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0103 0.0207 0.0196
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0025 0.0025
Onchocerca volvulus 0.003 0.0015 0.0008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0219 0.0219
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0044 0.0051 0.0577
Schistosoma mansoni hypothetical protein 0.0214 0.0505 0.0504
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0279 0.0678 0.0662
Trypanosoma brucei AMP deaminase, putative 0.0085 0.0161 0.0144
Schistosoma mansoni laminin gamma-3 chain 0.0214 0.0505 0.0504
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0051 0.0034
Schistosoma mansoni hypothetical protein 0.026 0.0627 0.0627
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0045 0.0053 0.0027
Schistosoma mansoni egf-like domain protein 0.0454 0.1142 0.1142
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0044 0.0051 0.0264
Leishmania major hypothetical protein, conserved 0.0107 0.0219 0.0194
Brugia malayi Probable ATP-dependent helicase DHX35 0.016 0.0361 0.0361
Onchocerca volvulus 0.0253 0.0608 0.0986
Loa Loa (eye worm) hypothetical protein 0.01 0.0201 0.0201
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0209 0.0491 0.0491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.026 0.0627 0.0627
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0112 0.0233 0.2836
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0053 0.077
Plasmodium vivax acyl-CoA synthetase, putative 0.0112 0.0233 0.0222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0216 0.1207
Echinococcus multilocularis G-protein coupled receptor, putative 0.026 0.0627 0.0627
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0045 0.0053 0.0035
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0044 0.0051 0.0577
Toxoplasma gondii P-type ATPase4, putative 0.0049 0.0065 0.0064
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0219 0.0219
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.004 0.0029
Echinococcus multilocularis acetylcholinesterase 0.0134 0.0292 0.0292
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0118 0.0111
Onchocerca volvulus 0.026 0.0627 0.1018
Loa Loa (eye worm) matrixin family protein 0.0038 0.0035 0.0035
Brugia malayi glutaminase DH11.1 0.0318 0.0782 0.0782
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0219 0.0209
Echinococcus multilocularis nervana 2 0.0253 0.0608 0.0607
Schistosoma mansoni hypothetical protein 0.0028 0.0009 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0025 0.0017
Loa Loa (eye worm) glutaminase 2 0.0318 0.0782 0.0782
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.004 0.0201
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0098 0.0098
Trypanosoma brucei N-myristoyl transferase, putative 0.3782 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0071 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.004 0.004 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0051 0.0577
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Toxoplasma gondii microneme protein MIC4 0.0206 0.0483 0.0559
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0086
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0051 0.0048
Echinococcus multilocularis adenosine deaminase 0.0262 0.0632 0.0631
Onchocerca volvulus 0.0206 0.0483 0.078
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Onchocerca volvulus 0.0206 0.0483 0.078
Echinococcus multilocularis protein jagged 2 0.0214 0.0505 0.0504
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0242 0.0242
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0219 0.1223
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0256 0.0255
Schistosoma mansoni notch 0.0214 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.016 0.0361 0.0361
Schistosoma mansoni histamine h1 receptor 0.026 0.0627 0.0627
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.3782 1 1
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0219 0.1223
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus multilocularis dro:myosuppressin receptor 0.026 0.0627 0.0627
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0219 0.0202
Brugia malayi jmjC domain containing protein 0.0036 0.0031 0.0031
Schistosoma mansoni calpain-7 (C02 family) 0.0029 0.0011 0.0011
Onchocerca volvulus 0.026 0.0627 0.1018
Onchocerca volvulus 0.026 0.0627 0.1018
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0253 0.0608 0.0607
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0045 0.0038
Schistosoma mansoni hypothetical protein 0.0214 0.0505 0.0504
Echinococcus multilocularis serotonin receptor 0.026 0.0627 0.0627
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.0368 0.0368
Echinococcus granulosus microtubule associated protein 2 0.1371 0.3583 0.3582
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0069 0.0118 0.0118
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0044 0.0051 0.0577
Schistosoma mansoni hypothetical protein 0.0029 0.0011 0.001
Echinococcus granulosus adenosine deaminase 0.0262 0.0632 0.0631
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0134 0.0133
Schistosoma mansoni ran 0.0047 0.0058 0.0058
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.026 0.0627 0.0627
Schistosoma mansoni neuropeptide receptor 0.026 0.0627 0.0627
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.015 0.0334 0.4959
Brugia malayi Pre-SET motif family protein 0.0839 0.2166 0.2166
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Brugia malayi Carboxylesterase family protein 0.0134 0.0292 0.0292
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0027 0.0026
Loa Loa (eye worm) beta-lactamase 0.0107 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0253 0.0608 0.0608
Onchocerca volvulus Arrow homolog 0.0454 0.1142 0.1867
Echinococcus granulosus chromobox protein 1 0.0069 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0107 0.0219 0.0219
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0219 0.0219
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0071 0.0071
Schistosoma mansoni biogenic amine (dopamine) receptor 0.026 0.0627 0.0627
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0031 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0103 0.0086
Echinococcus multilocularis Mastin 0.0328 0.0807 0.0807
Brugia malayi follicle stimulating hormone receptor 0.026 0.0627 0.0627
Mycobacterium ulcerans acyl-CoA synthetase 0.015 0.0334 0.4095
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.015 0.0334 0.4095
Schistosoma mansoni opsin-like receptor 0.026 0.0627 0.0627
Schistosoma mansoni amine GPCR 0.026 0.0627 0.0627
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0058 0.0058
Echinococcus granulosus delta-like protein 1 0.0214 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus granulosus somatostatin receptor 0.026 0.0627 0.0627
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0454 0.1142 0.1142
Loa Loa (eye worm) Notch2 0.0214 0.0505 0.0505
Echinococcus multilocularis rhodopsin orphan GPCR 0.026 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.0406 0.1015 0.1015
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0209 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus granulosus nervana 2 0.0209 0.0491 0.0491
Trypanosoma cruzi N-myristoyl transferase, putative 0.3782 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0073 0.0062
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0103 0.0207 0.1153
Mycobacterium ulcerans leucyl aminopeptidase 0.0103 0.0207 0.2516
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.0908 0.0908
Echinococcus multilocularis integrin beta 2 0.0526 0.1334 0.1334
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0083 0.0082
Giardia lamblia Rrm3p helicase 0.0279 0.0678 0.0668
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0041 0.0042 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.026 0.0627 0.0627
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.026 0.0627 0.0627
Echinococcus granulosus acetylcholinesterase 0.0134 0.0292 0.0292
Schistosoma mansoni hypothetical protein 0.026 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.0328 0.0807 0.0807
Brugia malayi Trypsin family protein 0.0328 0.0807 0.0807
Echinococcus granulosus rhodopsin orphan GPCR 0.026 0.0627 0.0627
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0052 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0103 0.0207 0.019
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0279 0.0678 0.0677
Loa Loa (eye worm) integrin beta-2 0.0718 0.1846 0.1846
Loa Loa (eye worm) hypothetical protein 0.0112 0.0233 0.0233
Brugia malayi hypothetical protein 0.0052 0.0073 0.0073
Echinococcus granulosus notch 0.0214 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.0328 0.0807 0.0807
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0058 0.0041
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0219 0.0219
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.004 0.0029
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus granulosus neurogenic locus notch protein 4 0.0214 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Brugia malayi Dopamine receptor protein 1 0.026 0.0627 0.0627
Brugia malayi Na,K-ATPase alpha subunit 0.0129 0.0278 0.0278
Loa Loa (eye worm) PAN domain-containing protein 0.0206 0.0483 0.0483
Schistosoma mansoni notch 0.0214 0.0505 0.0504
Schistosoma mansoni hypothetical protein 0.0303 0.074 0.0739
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0085 0.0161 0.0136
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0058 0.0058
Echinococcus multilocularis cpg binding protein 0.003 0.0014 0.0014
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0279 0.0678 0.0654
Loa Loa (eye worm) hypothetical protein 0.0129 0.0278 0.0278
Leishmania major 4-coumarate:coa ligase-like protein 0.015 0.0334 0.0309
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0256 0.029
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0044 0.0051 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0103 0.0086
Echinococcus multilocularis GPCR, family 2 0.0052 0.0071 0.0071
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0073 0.0073
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0328 0.0807 0.0807
Schistosoma mansoni microtubule-associated protein tau 0.1371 0.3583 0.3582
Loa Loa (eye worm) hypothetical protein 0.0107 0.0219 0.0219
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0303 0.074 0.0724
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Brugia malayi E1-E2 ATPase family protein 0.0029 0.0011 0.0011
Echinococcus granulosus GPCR family 2 0.0052 0.0071 0.0071
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0044 0.0051 0.0264
Toxoplasma gondii propionate-CoA ligase 0.0044 0.0051 0.0048
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0062 0.0098 0.0098
Brugia malayi neuropeptide F receptor 0.026 0.0627 0.0627
Schistosoma mansoni amine GPCR 0.026 0.0627 0.0627
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0029 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0005
Schistosoma mansoni cpg binding protein 0.003 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Brugia malayi AMP-binding enzyme family protein 0.015 0.0334 0.0334
Echinococcus granulosus thyrotropin releasing hormone receptor 0.026 0.0627 0.0627
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0073 0.0056
Echinococcus multilocularis laminin 0.0454 0.1142 0.1142
Brugia malayi Pre-SET motif family protein 0.0121 0.0256 0.0256
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0051 0.0051
Echinococcus granulosus neuropeptide receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0094 0.0185 0.0168
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus multilocularis calpain A 0.0062 0.0098 0.0098
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0454 0.1142 0.1142
Echinococcus multilocularis rhodopsin orphan GPCR 0.026 0.0627 0.0627
Brugia malayi hypothetical protein 0.0113 0.0234 0.0234
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0097 0.0097
Onchocerca volvulus 0.0044 0.0051 0.0068
Onchocerca volvulus 0.0125 0.0266 0.0422
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0025 0.0025
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0044 0.0051 0.0264
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0049 0.0065 0.0064
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.026 0.0627 0.0627
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.026 0.0627 0.0627
Brugia malayi G protein-coupled receptor 0.026 0.0627 0.0627
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.004 0.004
Schistosoma mansoni amine GPCR 0.026 0.0627 0.0627
Onchocerca volvulus 0.026 0.0627 0.1018
Loa Loa (eye worm) hypothetical protein 0.0206 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Leishmania major calcium-translocating P-type ATPase 0.0045 0.0053 0.0027
Trypanosoma cruzi AMP deaminase, putative 0.0085 0.0161 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0037 0.003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0219 0.1223
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0017
Echinococcus granulosus neuropeptide receptor 0.026 0.0627 0.0627
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0051 0.0264
Onchocerca volvulus 0.0037 0.0032 0.0036
Brugia malayi gonadotropin-releasing hormone receptor 2 0.026 0.0627 0.0627
Plasmodium vivax P-type ATPase4, putative 0.0049 0.0065 0.0054
Schistosoma mansoni adenosine deaminase-related 0.0262 0.0632 0.0631
Entamoeba histolytica adenosine deaminase, putative 0.0262 0.0632 0.0632
Onchocerca volvulus Neuropeptide F receptor homolog 0.026 0.0627 0.1018
Loa Loa (eye worm) hypothetical protein 0.015 0.0334 0.0334
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0279 0.0678 0.0662
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0051 0.0577
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Echinococcus multilocularis protein jagged 1 0.0214 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Echinococcus multilocularis Niemann Pick C1 protein 0.0068 0.0116 0.0115
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Schistosoma mansoni notch 0.0214 0.0505 0.0504
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0045 0.0053 0.0045
Loa Loa (eye worm) hypothetical protein 0.0206 0.0483 0.0483
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0045 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Trypanosoma cruzi AMP deaminase, putative 0.0085 0.0161 0.0144
Echinococcus multilocularis protein patched 0.0029 0.0012 0.0012
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0044 0.0051 0.0186
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0219 0.3024
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0045 0.0053 0.0027
Brugia malayi EGF-like domain containing protein 0.0214 0.0505 0.0505
Echinococcus granulosus g protein coupled receptor 0.026 0.0627 0.0627
Treponema pallidum adenosine deaminase 0.0262 0.0632 1
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0049 0.0065 0.0064
Echinococcus multilocularis slit 2 protein 0.0214 0.0505 0.0504
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0029 0.0012 0.0012
Brugia malayi mbt repeat family protein 0.0049 0.0064 0.0064
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.0035 0.0042
Onchocerca volvulus 0.0107 0.0219 0.0345
Schistosoma mansoni inositol monophosphatase 0.0045 0.0053 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0132 0.0286 0.0285
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0053 0.0046
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0129 0.0278 0.0277
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0062 0.0098 0.0098
Echinococcus granulosus g protein coupled receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0111 0.023 0.023
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0057 0.0086 0.0086
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0049 0.0065 0.0064
Echinococcus granulosus neural cadherin 0.0214 0.0505 0.0504
Entamoeba histolytica acyl-CoA synthetase, putative 0.015 0.0334 0.0334
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.026 0.0627 0.0627
Echinococcus granulosus fmrfamide receptor 0.026 0.0627 0.0627
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.3782 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.026 0.0627 0.0627
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0071 0.0071
Echinococcus granulosus cpg binding protein 0.003 0.0014 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0154 0.0343 0.0343
Toxoplasma gondii PAN domain-containing protein 0.3204 0.8461 1
Brugia malayi EGF-like domain containing protein 0.0214 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0163 0.0368 0.0368
Brugia malayi beta-lactamase family protein 0.0107 0.0219 0.0219
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0051 0.0026
Schistosoma mansoni hypothetical protein 0.0052 0.0071 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.026 0.0627 0.0627
Schistosoma mansoni opsin-like receptor 0.026 0.0627 0.0627
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.026 0.0627 0.0627
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0051 0.0577
Loa Loa (eye worm) hypothetical protein 0.0086 0.0164 0.0164
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0045 0.0053 0.0045
Loa Loa (eye worm) hypothetical protein 0.2307 0.6073 0.6073
Leishmania major adenine aminohydrolase 0.0262 0.0632 0.0608
Echinococcus multilocularis neurogenic locus notch protein 4 0.0214 0.0505 0.0504
Echinococcus multilocularis nervana 2 0.0209 0.0491 0.0491
Brugia malayi Bromodomain containing protein 0.0029 0.0011 0.0011
Echinococcus granulosus enteropeptidase 0.0328 0.0807 0.0807
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0073 0.0056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0185 0.0185
Toxoplasma gondii exonuclease III APE 0.004 0.004 0.0035
Echinococcus granulosus tachykinin peptides receptor 99D 0.026 0.0627 0.0627
Leishmania major hypothetical protein, conserved 0.0085 0.0161 0.0136
Echinococcus granulosus neurogenic locus notch protein 0.0214 0.0505 0.0504
Echinococcus multilocularis neuropeptide receptor A26 0.026 0.0627 0.0627
Brugia malayi Niemann-Pick C1 protein precursor 0.0068 0.0116 0.0116
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.026 0.0627 0.0627
Mycobacterium ulcerans acetyl-CoA synthetase 0.0044 0.0051 0.0577
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0253 0.0608 0.0607
Brugia malayi notch-like transmembrane receptor 0.0214 0.0505 0.0505
Echinococcus granulosus calpain A 0.0062 0.0098 0.0098
Echinococcus granulosus Niemann Pick C1 protein 0.0068 0.0116 0.0115
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0044 0.0051 0.0264
Onchocerca volvulus 0.2307 0.6073 1
Echinococcus multilocularis g protein coupled receptor 0.026 0.0627 0.0627
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.004 0.004
Loa Loa (eye worm) trypsin family protein 0.0328 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Echinococcus granulosus expressed conserved protein 0.0064 0.0105 0.0104
Trypanosoma cruzi N-myristoyl transferase, putative 0.3782 1 1
Leishmania major calcium motive p-type ATPase, putative 0.0049 0.0065 0.004
Echinococcus granulosus calcium transporting atpase 0.0049 0.0065 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0097 0.0097
Schistosoma mansoni amine GPCR 0.026 0.0627 0.0627
Toxoplasma gondii calcium binding egf domain-containing protein 0.0454 0.1142 0.1339
Onchocerca volvulus 0.0328 0.0807 0.1315
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0053 0.0046
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0103 0.0207 0.0182
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.004 0.0029
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Echinococcus multilocularis rhodopsin orphan GPCR 0.026 0.0627 0.0627
Leishmania major hypothetical protein, conserved 0.0303 0.074 0.0716
Brugia malayi Kringle domain containing protein 0.0303 0.074 0.074
Schistosoma mansoni growth hormone secretagogue receptor 0.026 0.0627 0.0627
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0049 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0045 0.0053 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.026 0.0627 0.0627
Echinococcus multilocularis AMP deaminase 2 0.0085 0.0161 0.0161
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0051 0.0577
Brugia malayi Calcium binding EGF domain containing protein 0.0214 0.0505 0.0505
Brugia malayi Matrixin family protein 0.0041 0.0044 0.0044
Schistosoma mansoni ran 0.0047 0.0058 0.0058
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0103 0.0207 0.019
Echinococcus granulosus jumonji domain containing protein 0.004 0.0041 0.004
Echinococcus granulosus Tolloid protein 1 0.0454 0.1142 0.1142
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.026 0.0627 0.0627
Echinococcus multilocularis calpain family protein 1, d 0.0043 0.005 0.0049
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0303 0.074 0.0724
Loa Loa (eye worm) hypothetical protein 0.0206 0.0483 0.0483
Schistosoma mansoni rhodopsin-like orphan GPCR 0.026 0.0627 0.0627
Schistosoma mansoni rhodopsin-like orphan GPCR 0.026 0.0627 0.0627
Echinococcus multilocularis G protein coupled receptor 139 0.026 0.0627 0.0627
Echinococcus granulosus G protein coupled receptor 139 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0134 0.0292 0.0292
Brugia malayi hypothetical protein 0.0034 0.0024 0.0024
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0045 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0253 0.0608 0.0608
Echinococcus granulosus rhodopsin orphan GPCR 0.026 0.0627 0.0627
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0279 0.0678 0.0654
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0045 0.0053 0.0045
Echinococcus granulosus sterol regulatory element binding protein 0.0029 0.0012 0.0012
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0065 0.0058
Mycobacterium ulcerans hypothetical protein 0.0107 0.0219 0.2668
Loa Loa (eye worm) neuropeptide F receptor 0.026 0.0627 0.0627
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0103 0.0207 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0011 0.001
Echinococcus granulosus nervana 2 0.0253 0.0608 0.0607
Brugia malayi putative neuropeptide receptor 0.026 0.0627 0.0627
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0064 0.0064
Echinococcus multilocularis g-protein coupled receptor 0.026 0.0627 0.0627
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.026 0.0627 0.0627
Toxoplasma gondii subtilisin SUB12 0.0206 0.0483 0.0559
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0085 0.0161 0.0136
Onchocerca volvulus 0.026 0.0627 0.1018
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0058 0.0058
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0454 0.1142 0.1142
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0097 0.0097
Brugia malayi MH2 domain containing protein 0.0366 0.0908 0.0908
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0256 0.0255
Trichomonas vaginalis cation-transporting ATPase, putative 0.0045 0.0053 0.0045
Onchocerca volvulus 0.0085 0.0161 0.025
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0118 0.0111
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Schistosoma mansoni biogenic amine (5HT) receptor 0.026 0.0627 0.0627
Echinococcus granulosus neuropeptide FF receptor 2 0.026 0.0627 0.0627
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0051 0.0051
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.3782 1 1
Echinococcus multilocularis enteropeptidase 0.0328 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Entamoeba histolytica hypothetical protein, conserved 0.0279 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.008 0.0147 0.0147
Schistosoma mansoni biogenic amine (dopamine) receptor 0.026 0.0627 0.0627
Echinococcus multilocularis fmrfamide receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.0469 0.0469
Brugia malayi Trypsin family protein 0.2307 0.6073 0.6073
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0094 0.0185 0.0168
Onchocerca volvulus Neurogenic locus notch homolog 0.0214 0.0505 0.0816
Echinococcus multilocularis orexin receptor type 2 0.026 0.0627 0.0627
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) TK/ROR protein kinase 0.0303 0.074 0.074
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0053 0.0036
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0214 0.0505 0.0505
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.004 0.0435
Echinococcus granulosus biogenic amine 5HT receptor 0.026 0.0627 0.0627
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0125 0.0266 0.3247
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0073 0.0062
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0044 0.0051 0.0264
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0279 0.0678 0.0662
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.3782 1 1
Schistosoma mansoni hypothetical protein 0.0214 0.0505 0.0504
Echinococcus granulosus dro:myosuppressin receptor 0.026 0.0627 0.0627
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0051 0.0577
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0097 0.0097
Entamoeba histolytica DNA repair and recombination protein, putative 0.0279 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0049 0.0064 0.0064
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0253 0.0608 0.0607
Brugia malayi AMP-binding enzyme family protein 0.015 0.0334 0.0334
Echinococcus multilocularis tachykinin peptides receptor 99D 0.026 0.0627 0.0627
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0058 0.0041
Leishmania major AMP deaminase, putative 0.0085 0.0161 0.0136
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0051 0.0034
Schistosoma mansoni survival motor neuron protein 0.0047 0.0059 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0219 0.0212
Schistosoma mansoni biogenic amine (5HT) receptor 0.026 0.0627 0.0627
Echinococcus multilocularis carboxylesterase 5A 0.0134 0.0292 0.0292
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0051 0.0577
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0118 0.0118
Schistosoma mansoni alpha-1 adrenergic receptor 0.026 0.0627 0.0627
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.1015 0.1015
Brugia malayi Serotonin receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0107 0.0219 0.0219
Trichomonas vaginalis ran, putative 0.0047 0.0058 0.0051
Loa Loa (eye worm) hypothetical protein 0.0177 0.0404 0.0404
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0059 0.0091 0.0091
Onchocerca volvulus 0.0049 0.0064 0.009
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0051 0.0034
Loa Loa (eye worm) calpain family protein 1 0.0043 0.005 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0154 0.0343 0.0343
Brugia malayi AMP-binding enzyme family protein 0.015 0.0334 0.0334
Echinococcus multilocularis fmrfamide receptor 0.026 0.0627 0.0627
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Toxoplasma gondii leucyl aminopeptidase LAP 0.0103 0.0207 0.0232
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0044 0.0051 0.0577
Brugia malayi Calcium binding EGF domain containing protein 0.0214 0.0505 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0037 0.003
Entamoeba histolytica hypothetical protein 0.0154 0.0343 0.0343
Brugia malayi G-protein coupled receptor 0.026 0.0627 0.0627
Echinococcus multilocularis glycoprotein Antigen 5 0.0328 0.0807 0.0807
Schistosoma mansoni hypothetical protein 0.0052 0.0071 0.0071
Echinococcus multilocularis protein dispatched 1 0.0033 0.0023 0.0023
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0085 0.0161 0.0161
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0025 0.0008
Echinococcus granulosus snurportin 1 0.0678 0.1739 0.1738
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0085 0.0161 0.0144
Plasmodium vivax SET domain protein, putative 0.0121 0.0256 0.0245
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.026 0.0627 0.0627
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0025 0.0017
Echinococcus granulosus Mastin 0.0328 0.0807 0.0807
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0083 0.0083
Loa Loa (eye worm) DEAH box polypeptide 35 0.016 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Brugia malayi TAR-binding protein 0.0061 0.0097 0.0097
Echinococcus granulosus 7TM GPCR rhodopsin 0.026 0.0627 0.0627
Brugia malayi Fibulin-1 precursor 0.0454 0.1142 0.1142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0453 0.0452
Echinococcus multilocularis g protein coupled receptor 0.026 0.0627 0.0627
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.0469 0.0469
Trypanosoma brucei calcium-translocating P-type ATPase 0.0049 0.0065 0.0048
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Mycobacterium tuberculosis Conserved protein 0.0107 0.0219 0.1223
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0025 0.0008
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0044 0.0051 0.0186
Loa Loa (eye worm) PAN domain-containing protein 0.0206 0.0483 0.0483
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0011 0.001
Echinococcus multilocularis neuropeptide receptor 0.026 0.0627 0.0627
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0112 0.0233 1
Loa Loa (eye worm) melatonin receptor type 1A 0.026 0.0627 0.0627
Brugia malayi Carboxylesterase family protein 0.0134 0.0292 0.0292
Brugia malayi calpain family protein 1 0.0059 0.0091 0.0091
Brugia malayi Integrin beta pat-3 precursor 0.0718 0.1846 0.1846
Echinococcus multilocularis rhodopsin orphan GPCR 0.026 0.0627 0.0627
Echinococcus multilocularis sterol regulatory element binding protein 0.0029 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Echinococcus granulosus AMP deaminase 2 0.0085 0.0161 0.0161
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0071 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.026 0.0627 0.0627
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0051 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0328 0.0807 0.0807
Echinococcus multilocularis calcium transporting atpase 0.0049 0.0065 0.0064
Brugia malayi neuropeptide F receptor 0.026 0.0627 0.0627
Echinococcus granulosus g-protein coupled receptor 0.026 0.0627 0.0627
Toxoplasma gondii EGF family domain-containing protein 0.0214 0.0505 0.0585
Onchocerca volvulus 0.026 0.0627 0.1018
Loa Loa (eye worm) hypothetical protein 0.0206 0.0483 0.0483
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0219 0.1223
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Trypanosoma cruzi AMP deaminase, putative 0.0085 0.0161 0.0144
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.026 0.0627 0.0627
Plasmodium vivax calcium-transporting ATPase, putative 0.0049 0.0065 0.0054
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0049 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0328 0.0807 0.0807
Echinococcus granulosus rhodopsin orphan GPCR 0.026 0.0627 0.0627
Toxoplasma gondii PAN domain-containing protein 0.0206 0.0483 0.0559
Trichomonas vaginalis cation-transporting ATPase, putative 0.0045 0.0053 0.0045
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0094 0.0185 0.016
Onchocerca volvulus AMP deaminase 2 homolog 0.0085 0.0161 0.025
Schistosoma mansoni hypothetical protein 0.0052 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0045 0.0053 0.0045
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0045 0.0053 0.0045
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0053 0.005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.004 0.0199
Echinococcus multilocularis notch 0.0214 0.0505 0.0504
Onchocerca volvulus 0.026 0.0627 0.1018
Echinococcus granulosus dnaJ subfamily B 0.0406 0.1015 0.1015
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0044 0.0051 0.0577
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0011 0.001
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0058 0.0048
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0051 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0256 0.0255
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0045 0.0053 0.0042
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0113 0.0234 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.026 0.0627 0.0627
Onchocerca volvulus 0.1979 0.52 0.856
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.015 0.0334 0.4959
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Schistosoma mansoni cercarial elastase (S01 family) 0.0328 0.0807 0.0807
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0049 0.0065 0.0064
Schistosoma mansoni adenoreceptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0219 0.0212
Echinococcus granulosus carboxylesterase 5A 0.0134 0.0292 0.0292
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0044 0.0051 0.0048
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0041 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0195 0.0453 0.0453
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0064 0.0064
Echinococcus granulosus nervana 2 0.0209 0.0491 0.0491
Onchocerca volvulus 0.026 0.0627 0.1018
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0049 0.0065 0.0064
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0071 0.0071
Trichomonas vaginalis ap endonuclease, putative 0.004 0.004 0.0033
Schistosoma mansoni acetyl-CoA synthetase 0.0044 0.0051 0.0051
Schistosoma mansoni AMP deaminase 0.0085 0.0161 0.0161
Schistosoma mansoni cpg binding protein 0.0029 0.001 0.001
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0058 0.0056
Brugia malayi Serotonin/octopamine receptor family protein 7 0.026 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.0876 0.2266 0.2266
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.001 0.001
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.026 0.0627 0.0627
Schistosoma mansoni neuropeptide receptor 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0112 0.0233 0.0233
Schistosoma mansoni hypothetical protein 0.0876 0.2266 0.2266
Echinococcus multilocularis expressed conserved protein 0.0064 0.0105 0.0104
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0044 0.0051 0.0264
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.031 0.076 0.076
Schistosoma mansoni hypothetical protein 0.0214 0.0505 0.0504
Brugia malayi hypothetical protein 0.023 0.0545 0.0545
Trichomonas vaginalis rotamase, putative 0.0303 0.074 0.0733
Toxoplasma gondii PAN domain-containing protein 0.0206 0.0483 0.0559
Echinococcus granulosus nervana 2 0.0253 0.0608 0.0607
Schistosoma mansoni neuropeptide f receptor 76f 0.026 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.026 0.0627 0.0627
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0262 0.0632 0.358
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Schistosoma mansoni ATPase 0.0045 0.0053 0.0052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0053 0.0046
Echinococcus granulosus leucine aminopeptidase protein 0.0103 0.0207 0.0206
Echinococcus multilocularis somatostatin receptor 0.026 0.0627 0.0627
Brugia malayi Melatonin receptor type 1A 0.026 0.0627 0.0627
Loa Loa (eye worm) acetylcholinesterase 1 0.0134 0.0292 0.0292
Echinococcus multilocularis allatostatin A receptor 0.026 0.0627 0.0627
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0051 0.0264
Loa Loa (eye worm) carboxylesterase 0.0134 0.0292 0.0292
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0121 0.0256 0.0255
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0044 0.0051 0.0051
Brugia malayi Calcium binding EGF domain containing protein 0.0454 0.1142 0.1142
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Brugia malayi hypothetical protein 0.026 0.0627 0.0627
Onchocerca volvulus 0.026 0.0627 0.1018
Loa Loa (eye worm) PAN domain-containing protein 0.0206 0.0483 0.0483
Onchocerca volvulus 0.0328 0.0807 0.1315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0453 0.0452
Echinococcus granulosus tm gpcr rhodopsin 0.151 0.3954 0.3954
Brugia malayi Calcium binding EGF domain containing protein 0.0214 0.0505 0.0505
Echinococcus multilocularis expressed protein 0.031 0.076 0.0759
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0049 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0662 0.1696 0.1696
Brugia malayi Trypsin family protein 0.0328 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0214 0.0505 0.0505
Onchocerca volvulus Adenosine deaminase homolog 0.0262 0.0632 0.1025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.009 0.0093
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0051 0.0034
Brugia malayi Tachykinin-like peptides receptor 99D 0.026 0.0627 0.0627
Mycobacterium ulcerans hypothetical protein 0.015 0.0334 0.4095
Loa Loa (eye worm) oxidoreductase 0.0044 0.0051 0.0051
Trichomonas vaginalis rotamase, putative 0.031 0.076 0.0753
Trichomonas vaginalis adenosine deaminase, putative 0.0262 0.0632 0.0625
Echinococcus multilocularis neural cadherin 0.0214 0.0505 0.0504
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0306 0.0748 0.0748
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2307 0.6073 0.6073
Echinococcus multilocularis neuropeptide Y receptor 0.026 0.0627 0.0627
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0216 0.1207
Trypanosoma brucei C-8 sterol isomerase, putative 0.0662 0.1696 0.1682
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0053 0.0036
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.026 0.0627 0.0627
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0058 0.0048
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0303 0.074 0.074
Plasmodium falciparum importin beta, putative 0.0064 0.0103 0.0092
Echinococcus multilocularis protein jagged 1 0.0214 0.0505 0.0504
Toxoplasma gondii ABC1 family protein 0.0107 0.0219 0.0247
Echinococcus granulosus expressed protein 0.031 0.076 0.0759
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.0908 0.0908
Brugia malayi beta-lactamase family protein 0.0107 0.0219 0.0219
Trichomonas vaginalis adenosine deaminase, putative 0.0262 0.0632 0.0625
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0253 0.0608 0.0607
Echinococcus multilocularis geminin 0.0876 0.2266 0.2266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.026 0.0627 0.0627
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0454 0.1142 0.1142
Schistosoma mansoni ap endonuclease 0.004 0.004 0.004
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0053 0.0052
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0083 0.0082
Echinococcus multilocularis peregrin 0.0029 0.0011 0.001
Brugia malayi PAN domain containing protein 0.0206 0.0483 0.0483
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0198 0.0198
Leishmania major N-myristoyl transferase, putative 0.3782 1 1
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.026 0.0627 0.0627
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0062 0.01 0.0099

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 35 nM Agonist activity measured on mouse vas deferens (MVD) ChEMBL. 6310111
IC50 ratio (functional) = 1 Irreversible antagonism to ethylketazocine (EK) was evaluated after 30 min incubation of GPI with the compound at 20 nM conc. ChEMBL. 6310111
IC50 ratio (functional) = 1.1 Antagonist potency relative to DADLE at 200 nM concentration ChEMBL. 6310111
IC50 ratio (functional) = 1.2 Irreversible antagonism to ethylketazocine (EK) was evaluated after 30 min incubation of GPI with the compound at 200 nM conc. ChEMBL. 6310111
IC50 ratio (functional) = 1.3 Irreversible antagonism to ethylketazocine (EK) was evaluated after 30 min incubation of GPI with the compound at 1000 nM conc. ChEMBL. 6310111
IC50 ratio (functional) = 1.8 Antagonist potency relative to DADLE at 100 nM concentration ChEMBL. 6310111
IC50 ratio (functional) = 3.9 Antagonist potency relative to morphine at 100 nM concentration ChEMBL. 6310111
IC50 ratio (functional) = 5 Agonistic potency on the guinea pig ileal longitudinal muscle (GPI) relative to morphine. ChEMBL. 6310111
IC50 ratio (functional) = 6 Irreversible antagonism to morphine was evaluated after 30 min incubation of GPI with the compound at 20 nM conc. ChEMBL. 6310111
IC50 ratio (functional) = 10.6 Antagonist potency relative to morphine at 200 nM concentration ChEMBL. 6310111
IC50 ratio (functional) = 18.8 Irreversible antagonism to morphine was evaluated after 30 min incubation of GPI with the compound at 1000 nM conc. ChEMBL. 6310111

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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