Detailed information for compound 290043

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 539.109 | Formula: C30H39ClN4O3
  • H donors: 0 H acceptors: 3 LogP: 4.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)CC2CCN(CC2)C(=O)OC(C)(C)C)nccc1
  • InChi: 1S/C30H39ClN4O3/c1-30(2,3)38-29(37)35-13-10-21(11-14-35)19-26(36)33-15-17-34(18-16-33)28-25-9-8-24(31)20-23(25)7-6-22-5-4-12-32-27(22)28/h4-5,8-9,12,20-21,28H,6-7,10-11,13-19H2,1-3H3
  • InChiKey: YDDWRTVPRXYBAT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyltransferase, CAAX box, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium hominis farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus granulosus protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus multilocularis protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative Get druggable targets OG5_128459 All targets in OG5_128459
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Theileria parva hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma mansoni protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium parvum farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Babesia bovis protein prenyltransferase alpha subunit repeat domain containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax prenyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium knowlesi protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium falciparum protein farnesyltransferase subunit alpha Get druggable targets OG5_128459 All targets in OG5_128459
Neospora caninum hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium berghei protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Giardia lamblia Rab geranylgeranyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0209 0.016 0.1805
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0008 0.0239
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0003 0.0019
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0048 0.0135
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0048 0.0547
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0008 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0077
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.0008 0.0137
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0961 0.0778 0.0778
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0006 0.0052
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0049 0.0029 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0018 0.0133
Loa Loa (eye worm) phosphatidylinositol 3 0.0209 0.016 0.14
Loa Loa (eye worm) phosphatidylinositol kinase 0.0209 0.016 0.14
Onchocerca volvulus 0.005 0.003 0.0957
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.0176 0.2024
Echinococcus multilocularis cyclin dependent kinase 19 0.0159 0.0119 0.0119
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0227 0.0176 0.0176
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0048 0.0547
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.005 0.003 0.0255
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0374 0.0296 0.3514
Echinococcus granulosus tumor protein p63 0.0401 0.0318 0.0318
Leishmania major protein farnesyltransferase alpha subunit, putative 0.005 0.003 0.0079
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0314 0.0246 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1027 0.0832 0.9646
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0032 0.0032
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0018 1
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0008 0.0049
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0227 0.0176 0.1534
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0209 0.016 0.6467
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1015 0.0823 0.645
Brugia malayi Cytochrome P450 family protein 0.0023 0.0008 0.0074
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0043 0.0025 0.0777
Brugia malayi follicle stimulating hormone receptor 0.028 0.0219 0.2528
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0003 0.0003
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0209 0.016 0.016
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1015 0.0823 0.2363
Entamoeba histolytica serine/threonine protein kinase, putative 0.0227 0.0176 0.1982
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1015 0.0823 0.0823
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0037 0.0037
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0032 0.0015 0.0015
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0038 0.002 0.002
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0037 0.0037
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0008 0.0049
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1064 0.0862 0.2477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.0478 0.554
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0003 0.0003
Echinococcus granulosus casein kinase ii subunit beta 0.0043 0.0025 0.0025
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0005 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0956 0.0774 0.897
Toxoplasma gondii CMGC kinase, CK2 family 0.0162 0.0122 0.1482
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.0147 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0956 0.0774 0.897
Trichomonas vaginalis set domain proteins, putative 0.0279 0.0218 0.2517
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0008 0.0008
Echinococcus multilocularis survival motor neuron protein 1 0.0558 0.0447 0.0447
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0043 0.0025 0.0064
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.005 0.003 0.0083
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0039 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0122 0.1405
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0314 0.0246 0.2846
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0008 0.0049
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1027 0.0832 0.9644
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0003 0.0003
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.027 0.0211 0.0602
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0018 0.0133
Brugia malayi PXA domain containing protein 0.0024 0.0009 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0006 0.0052
Brugia malayi Protein kinase domain containing protein 0.0159 0.0119 0.1368
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0612 0.0491 0.6059
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0074
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0403 0.032 0.032
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.0095 0.1086
Schistosoma mansoni 6-phosphofructokinase 0.0129 0.0095 0.0733
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0015 0.0162
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0811 0.0654 0.7585
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0209 0.016 0.0458
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0018 0.0018
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0479 0.0382 0.4422
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0209 0.016 0.1249
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0533 0.0426 0.4909
Leishmania major hypothetical protein, conserved 0.0027 0.0012 0.0028
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.005 0.003 0.003
Echinococcus multilocularis protein kinase shaggy 0.006 0.0039 0.0039
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0025 0.022
Entamoeba histolytica hypothetical protein 0.0043 0.0024 0.0213
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0008 0.0008
Brugia malayi hypothetical protein 0.0043 0.0024 0.0262
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0314 0.0246 0.2156
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0008 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0122 0.1405
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0124
Loa Loa (eye worm) hypothetical protein 0.0038 0.002 0.0168
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0015 0.0122
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0209 0.016 0.1872
Onchocerca volvulus 0.0059 0.0037 0.1193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0553 0.0443 0.5125
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0008 0.0025
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0048 0.0547
Brugia malayi Pre-SET motif family protein 0.0036 0.0018 0.0196
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.0095 0.1086
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0018 0.0143
Echinococcus multilocularis expressed conserved protein 0.0097 0.0068 0.0068
Toxoplasma gondii FATC domain-containing protein 0.057 0.0457 0.5629
Schistosoma mansoni netrin receptor unc5 0.0017 0.0003 0.0012
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0018 0.049
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0008 0.0064
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0008 0.0049
Schistosoma mansoni kinase 0.0117 0.0085 0.0657
Trypanosoma cruzi hypothetical protein, conserved 0.4249 0.3477 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0003 0.0021
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus granulosus Ankyrin 0.0017 0.0003 0.0003
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0039 0.0292
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0209 0.016 0.016
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0032 0.0237
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0978 0.0792 0.9178
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0007 0.0053
Schistosoma mansoni hypothetical protein 0.0037 0.0019 0.0141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0194 0.0148 0.129
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0001 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1015 0.0823 0.9539
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0314 0.0246 0.3021
Brugia malayi hypothetical protein 0.0194 0.0148 0.17
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.003 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0978 0.0791 0.9177
Loa Loa (eye worm) hypothetical protein 0.0052 0.0032 0.0268
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0003 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0006 0.0052
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0049 0.0029 0.0327
Giardia lamblia Kinase, PLK 0.0227 0.0176 0.2055
Loa Loa (eye worm) hypothetical protein 0.0786 0.0634 0.5564
Schistosoma mansoni ap endonuclease 0.002 0.0006 0.0034
Echinococcus multilocularis geminin 0.0199 0.0152 0.0152
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1005 0.0814 0.9784
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0855 0.0691 0.7999
Echinococcus granulosus single minded 2 0.0043 0.0024 0.0024
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0314 0.0246 0.2809
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0006 0.0052
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0314 0.0246 0.2847
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0479 0.0382 0.4421
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0403 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0119 0.0087 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.0809 0.9385
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0003 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0012 0.0029
Loa Loa (eye worm) phosphatidylinositol 3 0.0209 0.016 0.14
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0039 0.0433
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0018 0.0138
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0193 0.0147 0.1652
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0381 0.0302 0.0302
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1027 0.0832 0.2277
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0024 0.0024
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0015 0.0162
Onchocerca volvulus 0.0114 0.0082 0.2702
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0001 0.0002
Trypanosoma brucei polo-like protein kinase 0.0227 0.0176 0.2055
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0193 0.0147 0.1146
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0008 0.0008
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0043 0.0025 0.0272
Trypanosoma cruzi polo-like protein kinase, putative 0.0227 0.0176 0.0501
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0209 0.016 0.6467
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0008 0.0008
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0209 0.016 0.1848
Brugia malayi SH2 domain containing protein 0.0403 0.032 0.3699
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0661 0.0532 0.616
Trichomonas vaginalis conserved hypothetical protein 0.0612 0.0491 0.5693
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0502 0.0401 0.4643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.0809 0.9385
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0381 0.0302 0.2642
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.0809 0.9385
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0018 0.049
Loa Loa (eye worm) phosphatidylinositol 3 0.1027 0.0832 0.7301
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0038 0.002 0.002
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0032 0.0015 0.0015
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0038 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.003 0.0223
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0969 0.0784 0.2146
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.003 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0074
Onchocerca volvulus 0.0119 0.0087 0.2843
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0983 0.0796 0.9231
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0212 0.0163 0.1423
Echinococcus granulosus dnaJ subfamily B 0.0445 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0317
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0008 0.0008
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0015 0.0157
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0013
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0479 0.0382 0.4422
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0008 0.0008
Toxoplasma gondii hypothetical protein 0.0023 0.0008 0.0064
Entamoeba histolytica protein kinase, putative 0.006 0.0039 0.0383
Echinococcus granulosus geminin 0.0199 0.0152 0.0152
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0209 0.016 0.1249
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0001 0.0003
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0018 0.0189
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0025 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.1027 0.0832 0.9646
Schistosoma mansoni hypothetical protein 0.0114 0.0082 0.0636
Echinococcus multilocularis Zinc finger, PHD finger 0.0314 0.0246 0.0246
Brugia malayi mbt repeat family protein 0.0052 0.0032 0.035
Echinococcus granulosus bloom syndrome protein 0.0025 0.001 0.001
Plasmodium falciparum glycogen synthase kinase 3 0.006 0.0039 0.1364
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0159 0.0119 0.1038
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0058
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Loa Loa (eye worm) hypothetical protein 0.0612 0.0491 0.431
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0119 0.0925
Loa Loa (eye worm) Csnk2b protein 0.0043 0.0025 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0403 0.032 0.3702
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0314 0.0246 0.0246
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1064 0.0862 0.2477
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0314 0.0246 0.2913
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0058
Toxoplasma gondii hypothetical protein 0.005 0.003 0.0338
Echinococcus multilocularis musashi 0.0032 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.1027 0.0832 0.9646
Entamoeba histolytica hypothetical protein 0.0209 0.016 0.1805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0623 0.0501 0.58
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.006 0.0039 0.0102
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0038 0.002 0.002
Loa Loa (eye worm) phosphofructokinase 0.0129 0.0095 0.0824
Giardia lamblia Kinase, CMGC GSK 0.006 0.0039 0.0397
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0003 0.0003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0083 0.0946
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0227 0.0176 0.0478
Brugia malayi M-phase phosphoprotein, mpp8 0.0119 0.0087 0.099
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0535 0.0428 0.3355
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0271 0.3134
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0479 0.0382 0.1095
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0314 0.0246 1
Brugia malayi hypoxia-induced factor 1 0.0179 0.0136 0.1558
Toxoplasma gondii hypothetical protein 0.0143 0.0106 0.1283
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0038 0.002 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1064 0.0862 1
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0013
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0018 0.0184
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0008 0.0049
Leishmania major protein kinase, putative 0.0019 0.0005 0.0009
Echinococcus granulosus protein prenyltransferase alpha subunit 0.005 0.003 0.003
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0038 0.002 0.0218
Entamoeba histolytica hypothetical protein 0.0023 0.0008 0.0022
Giardia lamblia Rab geranylgeranyltransferase 0.0193 0.0147 0.1713
Entamoeba histolytica hypothetical protein 0.057 0.0457 0.5266
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.0037 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0969 0.0784 0.9092
Onchocerca volvulus 0.0279 0.0218 0.722
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0018 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.0176 0.2024
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.0176 0.1368
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0008 0.0049
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0786 0.0634 0.0634
Brugia malayi SET domain containing protein 0.0015 0.0002 0.0002
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0032 0.1009
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0381 0.0302 0.3487
Echinococcus multilocularis lamin 0.0032 0.0015 0.0015
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0193 0.0147 0.1694
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0018 0.0189
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0129 0.0095 0.0269
Brugia malayi hypothetical protein 0.0018 0.0004 0.0024
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0074
Brugia malayi hypothetical protein 0.0558 0.0447 0.5178
Leishmania major phosphatidylinositol kinase related protein, putative 0.0226 0.0175 0.0475
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0032 0.0268
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.006 0.0039 0.0445
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0008 0.0072
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0032 0.0237
Echinococcus multilocularis casein kinase ii subunit alpha 0.0162 0.0122 0.0122
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0003 0.0003
Trypanosoma cruzi casein kinase II, putative 0.0162 0.0122 0.0348
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0039 0.0433
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0314 0.0246 0.2847
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0129 0.0095 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0209 0.016 0.1954
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0041 0.0462
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.0008 0.0137
Brugia malayi 6-phosphofructokinase 0.0129 0.0095 0.1084
Entamoeba histolytica casein kinase, putative 0.0162 0.0122 0.136
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0209 0.016 0.1846
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus granulosus voltage dependent calcium channel 0.0038 0.002 0.002
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0032 0.0015 0.016
Schistosoma mansoni hypothetical protein 0.0199 0.0152 0.1186
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0381 0.0302 0.0302
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0193 0.0147 0.593
Leishmania major hypothetical protein, conserved 0.4458 0.3649 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0314 0.0246 0.0246
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0018 0.1324
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0381 0.0302 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0003 0.0019
Giardia lamblia Rab geranylgeranyltransferase 0.005 0.003 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0978 0.0792 0.9178
Schistosoma mansoni cpg binding protein 0.0033 0.0016 0.0115
Echinococcus multilocularis expressed protein 0.0443 0.0352 0.0352
Giardia lamblia Kinase, CMGC GSK 0.006 0.0039 0.0397
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0008 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0003 0.0003
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0106 0.0076 0.0076
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0072 0.0048 0.0547
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0118
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0039 0.0445
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.005 0.003 0.0225
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0013
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0037 0.0037
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.057 0.0457 0.546
Schistosoma mansoni intermediate filament proteins 0.0032 0.0015 0.0106
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0122 0.1405
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0226 0.0175 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0041 0.0462
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.001 0.0096
Trypanosoma cruzi target of rapamycin kinase 3 0.1005 0.0814 0.2338
Schistosoma mansoni voltage-gated cation channel 0.0038 0.002 0.0147
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0043 0.0025 0.0777
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0072 0.0048 0.0516
Loa Loa (eye worm) phosphatidylinositol 3 0.0969 0.0784 0.6882
Giardia lamblia Kinase, CMGC CK2 0.0162 0.0122 0.141
Brugia malayi Uncoordinated protein 44 0.0017 0.0003 0.0018
Echinococcus granulosus 6 phosphofructokinase 0.0129 0.0095 0.0095
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0003 0.0003
Leishmania major ATP-dependent phosphofructokinase 0.0129 0.0095 0.0256
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0008 0.0072
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0024 0.205
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0015 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0602 0.0483 0.5592
Brugia malayi hypothetical protein 0.0119 0.0087 0.0991
Entamoeba histolytica protein kinase domain containing protein 0.0162 0.0122 0.136
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0008 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0018 0.0189
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0012
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0012 0.0109
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0018 0.0184
Brugia malayi intracellular kinase 0.006 0.0039 0.0432
Entamoeba histolytica hypothetical protein 0.0043 0.0024 0.0213
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0008 0.0072
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0008 0.006
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0039 0.0383
Schistosoma mansoni hypothetical protein 0.0403 0.032 0.2503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0978 0.0791 0.9177
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0012 0.0029
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1566 0.1274 0.1274
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0361 0.0285 0.0817
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0008 0.0049
Brugia malayi Pre-SET motif family protein 0.0245 0.019 0.2194
Echinococcus multilocularis lamin dm0 0.0032 0.0015 0.0015
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus granulosus lamin dm0 0.0032 0.0015 0.0015
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0344 0.0271 0.3134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.0478 0.554
Entamoeba histolytica hypothetical protein 0.0023 0.0008 0.0022
Brugia malayi Serotonin receptor 0.0553 0.0443 0.5128
Echinococcus multilocularis beta adrenergic receptor kinase 0.0027 0.0011 0.0011
Leishmania major casein kinase II, putative 0.0162 0.0122 0.0332
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0043 0.0025 0.0067
Echinococcus granulosus serine protein kinase ATM 0.057 0.0457 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.0176 0.2024
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0814 0.9438
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0008 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0814 0.9438
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0019 0.0005 0.0009
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1027 0.0832 0.6523
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0012 0.0353
Trypanosoma brucei hypothetical protein, conserved 0.005 0.003 0.0294
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0209 0.016 0.6425
Trypanosoma cruzi polo-like protein kinase, putative 0.0227 0.0176 0.0501
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0039 0.0039
Leishmania major hypothetical protein, unknown function 0.0209 0.016 0.0436
Loa Loa (eye worm) hypothetical protein 0.0558 0.0447 0.3921
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0479 0.0382 0.4393
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.001 0.0096
Schistosoma mansoni hypothetical protein 0.0043 0.0024 0.0177
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0015 0.0162
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0048 0.0547
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.057 0.0457 0.131
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0003 0.0018
Onchocerca volvulus 0.0032 0.0015 0.0456
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0006 0.0052
Brugia malayi CXXC zinc finger family protein 0.0031 0.0015 0.0153
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0209 0.016 0.6425
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.003 0.003
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0008 0.0072
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0019 0.0209
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.0095 0.1086
Loa Loa (eye worm) phosphatidylinositol 3 0.027 0.0211 0.1842
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0011 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.003 0.003
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0008 0.0205
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0038 0.002 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.0809 0.9385
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0008 0.0239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0789 0.0636 0.7376
Loa Loa (eye worm) phosphatidylinositol 3 0.0209 0.016 0.14
Echinococcus multilocularis voltage dependent calcium channel 0.0038 0.002 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0006 0.0052
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0006 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0018 0.0189
Onchocerca volvulus 0.0209 0.016 0.5297
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0106 0.0076 0.0583
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0008 0.0049
Schistosoma mansoni hypothetical protein 0.0097 0.0068 0.0526
Loa Loa (eye worm) RecQ helicase 0.0025 0.001 0.0075
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1064 0.0862 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0037 0.0419
Echinococcus granulosus survival motor neuron protein 1 0.0558 0.0447 0.0447
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0003 0.0018
Mycobacterium leprae conserved hypothetical protein 0.0209 0.016 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0553 0.0443 0.1269
Onchocerca volvulus 0.0031 0.0015 0.0444
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.0008 0.0239
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.005 0.003 0.1008
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0024 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0231 0.0178 0.2055
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0122 0.1405
Entamoeba histolytica phosphofructokinase, putative 0.0129 0.0095 0.1039
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Giardia lamblia GTOR 0.1027 0.0832 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0006 0.0052
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0024 0.0262
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.0478 0.554
Schistosoma mansoni cpg binding protein 0.0033 0.0016 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0083 0.0946
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0012 0.0237
Echinococcus granulosus GPCR family 2 0.0017 0.0003 0.0003
Plasmodium falciparum casein kinase II beta chain 0.0043 0.0025 0.0784
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.003 0.003
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0049 0.0029 0.0327
Brugia malayi PAS domain containing protein 0.0058 0.0036 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.0176 0.2024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.016 0.1848
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0008 0.0049
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0106 0.0076 0.0583
Onchocerca volvulus 0.0043 0.0024 0.0757
Loa Loa (eye worm) 6-phosphofructokinase 0.0129 0.0095 0.0824
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0103 0.0073 0.0073
Onchocerca volvulus Serine\/threonine kinase homolog 0.0227 0.0176 0.5802
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0034 0.0372
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0011 0.0075
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0314 0.0246 0.0705
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0008 0.0416
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0008 0.0019
Schistosoma mansoni ap endonuclease 0.002 0.0006 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.0809 0.9385
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0814 0.9438
Plasmodium falciparum casein kinase 2, alpha subunit 0.0162 0.0122 0.4841
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0252 0.0196 0.2304
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0058
Schistosoma mansoni hypothetical protein 0.0209 0.016 0.1249
Echinococcus multilocularis 6 phosphofructokinase 0.0129 0.0095 0.0095
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0038 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0978 0.0792 0.9178
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0645 0.0519 0.621
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1027 0.0832 0.2389
Toxoplasma gondii hypothetical protein 0.0023 0.0008 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0058
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0565 0.0453 0.5221
Plasmodium vivax SET domain protein, putative 0.0036 0.0018 0.0634
Trypanosoma brucei protein kinase, putative 0.006 0.0039 0.0397
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0072 0.0048 0.0516
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0037 0.0283
Brugia malayi Cytochrome P450 family protein 0.0035 0.0018 0.0191
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0209 0.016 0.1805
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0122 0.1405
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0193 0.0147 0.1285
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.005 0.003 0.0334
Echinococcus multilocularis cpg binding protein 0.0033 0.0016 0.0016
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0057 0.0035 0.0302
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.0095 0.1086
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0209 0.016 0.0458
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0018 0.0189
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.003 0.0253
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0018 0.0602
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0019 0.0005 0.0009
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0314 0.0246 0.2847
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0008 0.0074
Echinococcus multilocularis voltage dependent calcium channel 0.0038 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0058
Toxoplasma gondii exonuclease III APE 0.002 0.0006 0.0038
Echinococcus multilocularis Ankyrin 0.0017 0.0003 0.0003
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0209 0.016 0.1805
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0103 0.0073 0.0073
Onchocerca volvulus 0.0032 0.0015 0.0456
Toxoplasma gondii hypothetical protein 0.0063 0.0041 0.0475
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0003 0.0017
Schistosoma mansoni lamin 0.0032 0.0015 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0956 0.0774 0.897
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0041 0.0462
Loa Loa (eye worm) phosphatidylinositol 3 0.0209 0.016 0.14
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0072 0.0048 0.0369
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0018 0.0184
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.005 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.032
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0479 0.0382 0.4555
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0008 0.0008
Loa Loa (eye worm) phosphatidylinositol 3 0.1401 0.1139 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0018 0.0148
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0037 0.0037
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0162 0.0122 0.1065
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0018 0.0602
Loa Loa (eye worm) hypothetical protein 0.0361 0.0285 0.2499
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0212 0.0163 0.1876
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Mycobacterium tuberculosis Conserved hypothetical protein 0.0209 0.016 1
Brugia malayi phosphofructokinase 0.0129 0.0095 0.1084
Entamoeba histolytica hypothetical protein 0.0023 0.0008 0.0022
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.003 0.0294
Brugia malayi serine/threonine-protein kinase plk-2 0.0227 0.0176 0.2022
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0032 0.0015 0.016
Brugia malayi Protein kinase domain containing protein 0.0381 0.0302 0.3487
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0072 0.0048 0.0048
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.0147 0.1696
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0978 0.0792 0.9178
Echinococcus multilocularis dnaJ subfamily B 0.0445 0.0354 0.0354
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0003 0.0056
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0314 0.0246 0.0246
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0025 0.022
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1566 0.1274 0.1274
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0039 0.033
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.0029 0.0219
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0044 0.0338
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1027 0.0832 1
Echinococcus multilocularis tumor protein p63 0.0401 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0553 0.0443 0.388
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0209 0.016 0.14
Echinococcus multilocularis high voltage activated calcium channel beta 0.0103 0.0073 0.0073
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0032 0.0032
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0006 0.0052
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.005 0.003 0.1114
Echinococcus granulosus intermediate filament protein 0.0032 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0013
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0027 0.0011 0.011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0017 0.0017
Echinococcus multilocularis 0.0209 0.016 0.016
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0129 0.0095 0.1077
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.016 0.016
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0001 0.0001
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0001 0.0001
Echinococcus granulosus casein kinase ii subunit alpha 0.0162 0.0122 0.0122
Toxoplasma gondii ck2 beta subunit 0.0043 0.0025 0.0272
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0039 0.0383
Loa Loa (eye worm) calcium channel 0.0038 0.002 0.0168
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0018 0.0193
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0553 0.0443 0.5124
Leishmania major phosphatidylinositol 3-kinase, putative 0.0314 0.0246 0.0672
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.0219 0.1916
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1027 0.0832 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0002 0.0002
Leishmania major phosphatidylinositol kinase, putative 0.0209 0.016 0.0436
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0209 0.016 0.1846
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0018 0.0018
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0043 0.0025 0.0067
Loa Loa (eye worm) hypothetical protein 0.0193 0.0147 0.1285
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0027 0.0011 0.0087
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0006 0.0118
Schistosoma mansoni hypothetical protein 0.032 0.0251 0.1963
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0006 0.005
Loa Loa (eye worm) PXA domain-containing protein 0.0024 0.0009 0.007
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1015 0.0823 0.2363
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0011 0.0075
Plasmodium vivax casein kinase II beta chain, putative 0.0043 0.0025 0.0893
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1027 0.0832 0.9645
Onchocerca volvulus 0.006 0.0039 0.1242
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0106 0.0076 0.0076
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.003 0.0083
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0003 0.0012
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0018 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0027 0.0011 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0074
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0087 0.0061 0.0061
Trypanosoma brucei Casein kinase II 0.0162 0.0122 0.141
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0553 0.0443 0.0443
Echinococcus granulosus lamin 0.0032 0.0015 0.0015
Plasmodium vivax unspecified product 0.0162 0.0122 0.4902
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0227 0.0176 0.0176
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.2195 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.016 0.016
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0008 0.0008
Brugia malayi Csnk2b protein 0.0043 0.0025 0.0269
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.006 0.0039 0.0107
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0209 0.016 0.0458
Loa Loa (eye worm) gastrulation defective protein 1 0.0155 0.0116 0.1009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.003 0.0223
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0032 0.0032
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0899 0.0727 0.8417
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0122
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0024 0.0024
Echinococcus multilocularis serine protein kinase ATM 0.057 0.0457 0.0457
Onchocerca volvulus 0.0119 0.0087 0.2843
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0006 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0006 0.0041
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0001 0.0001
Leishmania major cytochrome p450-like protein 0.0023 0.0008 0.0018
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0008 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.0809 0.9385
Loa Loa (eye worm) hypothetical protein 0.0403 0.032 0.2804
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0032 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0038
Toxoplasma gondii target of rapamycin (TOR), putative 0.0999 0.0809 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1015 0.0823 0.0823
Brugia malayi PXA domain containing protein 0.0024 0.0009 0.0088
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Mycobacterium ulcerans 6-phosphofructokinase 0.0129 0.0095 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0245 0.019 0.1663
Brugia malayi hypothetical protein 0.0023 0.0008 0.0072
Onchocerca volvulus 0.0209 0.016 0.5297
Plasmodium vivax hypothetical protein, conserved 0.0209 0.016 0.6467
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0038 0.002 0.0147
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0039 0.033
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1027 0.0832 0.0832
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0012 0.0069
Plasmodium vivax casein kinase II beta chain, putative 0.0043 0.0025 0.0893
Schistosoma mansoni lamin 0.0032 0.0015 0.0106
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0034 0.0285
Schistosoma mansoni single-minded 0.0058 0.0036 0.0274
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0209 0.016 0.6467
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1064 0.0862 1
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.003 0.0083
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0006 0.0006
Brugia malayi mbt repeat family protein 0.0052 0.0032 0.035
Brugia malayi Protein kinase domain containing protein 0.0021 0.0006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0058
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0103 0.0073 0.0565
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0209 0.016 0.1848
Loa Loa (eye worm) hypothetical protein 0.0119 0.0087 0.0753
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0024 0.0024
Schistosoma mansoni aryl hydrocarbon receptor 0.0058 0.0036 0.0274
Echinococcus granulosus cyclin dependent kinase 19 0.0159 0.0119 0.0119
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0314 0.0246 0.1924
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0193 0.0147 0.0147
Echinococcus granulosus death domain containing protein 0.0017 0.0003 0.0003
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1064 0.0862 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0034 0.0285
Echinococcus granulosus high voltage activated calcium channel beta 0.0103 0.0073 0.0073
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0129 0.0095 0.5757
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0043 0.0025 0.0228
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0008 0.0008
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0162 0.0122 0.4902
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.005 0.003 0.0332
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0012 0.0237
Brugia malayi intermediate filament protein 0.0032 0.0015 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.003 0.0083
Brugia malayi 6-phosphofructokinase 0.0129 0.0095 0.1084
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0209 0.016 0.016
Entamoeba histolytica hypothetical protein 0.0043 0.0024 0.0213
Loa Loa (eye worm) MBCTL1 0.0059 0.0037 0.032
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0008 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0006 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0122 0.1405
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0072 0.0048 0.0547
Schistosoma mansoni survival motor neuron protein 0.0114 0.0082 0.0636
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0015 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.0176 0.2024
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0032 0.0015 0.0108
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0209 0.016 0.016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0006 0.5
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Loa Loa (eye worm) 6-phosphofructokinase 0.0129 0.0095 0.0824
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0061 0.0039 0.0294
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.005 0.003 0.0294
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0018 0.0189
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.057 0.0457 0.3577
Brugia malayi FAT domain containing protein 0.0403 0.032 0.3701
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1064 0.0862 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0018 0.0018
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0969 0.0784 0.9423
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0008 0.0232
Echinococcus granulosus protein kinase shaggy 0.006 0.0039 0.0039
Echinococcus granulosus expressed protein 0.0443 0.0352 0.0352
Brugia malayi hypothetical protein 0.0027 0.0012 0.0117
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0006 0.0013
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.0809 0.9385
Plasmodium vivax hypothetical protein 0.0209 0.016 0.6467
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0019 0.0005 0.0009
Schistosoma mansoni protein kinase 0.0162 0.0122 0.0949
Echinococcus granulosus expressed conserved protein 0.0097 0.0068 0.0068
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Entamoeba histolytica phosphofructokinase, putative 0.0129 0.0095 0.1039
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.001 0.0094
Loa Loa (eye worm) hypoxia-induced factor 1 0.0179 0.0136 0.1182
Entamoeba histolytica hypothetical protein 0.0899 0.0727 0.8417
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0008 0.0074
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0193 0.0147 0.0147
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0018 0.0189
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0567 0.0454 0.5237
Leishmania major phosphatidylinositol 3-kinase, putative 0.0956 0.0774 0.2118
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0209 0.016 0.0458
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.003 0.0294
Schistosoma mansoni fkbp-rapamycin associated protein 0.0553 0.0443 0.3465
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0019 0.0005 0.0009
Onchocerca volvulus 0.0052 0.0032 0.1009
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0193 0.0147 0.1696
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0209 0.016 0.1954
Leishmania major protein kinase, putative 0.0019 0.0005 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.0176 0.2024
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1027 0.0832 0.2277
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0048 0.0547
Schistosoma mansoni serine/threonine protein kinase 0.0381 0.0302 0.2358
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0008 0.0058
Echinococcus multilocularis bloom syndrome protein 0.0025 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0956 0.0774 0.897
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.057 0.0457 0.529
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1005 0.0814 0.2228
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1027 0.0832 0.2389
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0332 0.0261 0.2287
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0049 0.0029 0.0934
Entamoeba histolytica phosphofructokinase, putative 0.0129 0.0095 0.1039
Echinococcus granulosus beta-adrenergic receptor kinase 0.0027 0.0011 0.0011
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0314 0.0246 0.0672
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0553 0.0443 0.0443
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0008 0.0008
Schistosoma mansoni casein kinase II beta subunit 0.0043 0.0025 0.0182
Loa Loa (eye worm) hypothetical protein 0.0403 0.032 0.2802
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0048 0.0547
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.003 0.0223
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0381 0.0302 0.2642
Echinococcus granulosus cpg binding protein 0.0033 0.0016 0.0016
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0008 0.0049
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0114 0.0082 0.0941
Giardia lamblia Hypothetical protein 0.0209 0.016 0.1872
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.005 0.003 0.003
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1027 0.0832 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.0457 0.529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0814 0.9438
Brugia malayi Death domain containing protein 0.0017 0.0003 0.0018
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0048 0.0135
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0006 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0048 0.0547
Schistosoma mansoni 6-phosphofructokinase 0.0129 0.0095 0.0733
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0314 0.0246 0.0705
Giardia lamblia Phosphatidylinositol 4-kinase 0.0209 0.016 0.1872
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0814 0.9438
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0025 0.0271
Giardia lamblia Casein kinase II beta chain 0.0043 0.0025 0.0228
Plasmodium falciparum casein kinase II beta chain 0.0043 0.0025 0.0784
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0008 0.006
Schistosoma mansoni hypothetical protein 0.0445 0.0354 0.2771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.016 0.1848
Entamoeba histolytica protein kinase rad3, putative 0.0553 0.0443 0.5099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0565 0.0453 0.5246
Brugia malayi hypothetical protein 0.0023 0.0008 0.0072
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0634 0.0509 0.6097
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1027 0.0832 0.9644
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.0176 0.2024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0209 0.016 0.1846
Brugia malayi Casein kinase II, alpha chain 0.0162 0.0122 0.1404
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0129 0.0095 0.5876
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0034 0.0372
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0314 0.0246 0.1924
Brugia malayi Cytochrome P450 family protein 0.0023 0.0008 0.0074
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0209 0.016 0.1872
Plasmodium vivax glycogen synthase kinase 3, putative 0.006 0.0039 0.1466
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0314 0.0246 0.2809
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0193 0.0147 0.5881
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0122 0.1405
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0006 0.0012
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0048 0.0547
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0038 0.002 0.002
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0811 0.0654 0.7585
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0161
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1566 0.1274 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0087 0.0061 0.0061
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0786 0.0634 0.0634
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0003 0.0013
Echinococcus multilocularis GPCR, family 2 0.0017 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0983 0.0796 0.9231
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0051
Entamoeba histolytica hypothetical protein 0.0043 0.0024 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0978 0.0791 0.9177
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0209 0.016 0.1249
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0072 0.0048 0.0048
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0314 0.0246 0.3021
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0008 0.0008
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0209 0.016 0.016
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0479 0.0382 0.4422
Schistosoma mansoni hypothetical protein 0.0199 0.0152 0.1186
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.003 0.003
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0209 0.016 0.1954
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0008 0.0072
Leishmania major phosphatidylinositol 4-kinase, putative 0.0209 0.016 0.0436
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.005 0.003 0.0283
Schistosoma mansoni cpg binding protein 0.0031 0.0015 0.0104
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0956 0.0774 0.9296
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0048 0.0135
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0143 0.0106 0.1219
Echinococcus multilocularis casein kinase ii subunit beta 0.0043 0.0025 0.0025

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.4 uM In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene ChEMBL. 9526562
IC50 (binding) = 7.4 uM In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene ChEMBL. 9526562

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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