Detailed information for compound 303706

Basic information

Technical information
  • TDR Targets ID: 303706
  • Name: methyl 4-(3-formyl-2,4-dihydroxy-6-methylbenz oyl)oxy-2-hydroxy-3,6-dimethylbenzoate
  • MW: 374.341 | Formula: C19H18O8
  • H donors: 3 H acceptors: 6 LogP: 4.33 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(C)cc(c(c1O)C)OC(=O)c1c(C)cc(c(c1O)C=O)O
  • InChi: 1S/C19H18O8/c1-8-5-12(21)11(7-20)17(23)15(8)19(25)27-13-6-9(2)14(18(24)26-4)16(22)10(13)3/h5-7,21-23H,1-4H3
  • InChiKey: YLOYKYXNDHOHHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 4-(3-formyl-2,4-dihydroxy-6-methyl-benzoyl)oxy-2-hydroxy-3,6-dimethyl-benzoate
  • 4-[(3-formyl-2,4-dihydroxy-6-methylphenyl)-oxomethoxy]-2-hydroxy-3,6-dimethylbenzoic acid methyl ester
  • methyl 4-(2,4-dihydroxy-3-methanoyl-6-methyl-phenyl)carbonyloxy-2-hydroxy-3,6-dimethyl-benzoate
  • 4-(3-formyl-2,4-dihydroxy-6-methyl-benzoyl)oxy-2-hydroxy-3,6-dimethyl-benzoic acid methyl ester
  • atranorin
  • 479-20-9
  • KBio2_003191
  • KBio2_005759
  • Spectrum4_001700
  • KBio3_002552
  • NSC685591
  • SpecPlus_000239
  • Spectrum3_001716
  • 3-Hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl 3-formyl-2,4-dihydroxy-6-methylbenzoate
  • Benzoic acid, 3-formyl-2,4-dihydroxy-6-methyl-, 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl ester (9CI)
  • EINECS 207-527-7
  • Isophthalaldehydic acid, 2,4-dihydroxy-6-methyl-, 4-ester with methyl 3,6-dimethyl-beta-resorcylate (8CI)
  • NSC 249980
  • Antranoric acid
  • Atranoric acid
  • Atranorine
  • Benzoic acid, 3-formyl-2,4-dihydroxy-6-methyl-, 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl ester
  • Isophthalaldehydic acid, 2,4-dihydroxy-6-methyl-, 4-ester with methyl 3,6-dimethyl-.beta.-resorcylate
  • NSC87512
  • Parmelin
  • Parmelin acid
  • Usnarin
  • Usnarin acid
  • Spectrum5_000380
  • BSPBio_003332
  • SPBio_001858
  • KBio1_001279
  • KBioGR_002000
  • AIDS-059095
  • AIDS059095
  • SDCCGMLS-0066426.P001
  • KBioSS_000623
  • Spectrum_000143
  • DivK1c_006335
  • NSC 685591
  • ST5409573
  • SPECTRUM200034
  • NCGC00095465-01
  • NSC249980
  • Spectrum2_001749
  • KBio2_000623

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni myosin xvIII 0.0066 0.0897 0.3399
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0078 0.0285
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0273 0.2755
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0069 0.0249
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0024 0.0079
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0146 0.0884
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0012 0.0085 0.0505
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0427 0.0413
Echinococcus granulosus ephrin type A receptor 4 A 0.007 0.0959 0.0945
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0121 0.0446
Entamoeba histolytica cyclin family protein 0.0059 0.0791 0.485
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0066 0.0897 0.0883
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.0623 0.3803
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0137 0.0519
Brugia malayi Protein kinase domain containing protein 0.0048 0.0623 0.2355
Mycobacterium ulcerans hypothetical protein 0.0072 0.0983 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1615 0.6119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0897 0.3399
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0146 0.0884
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0243 0.1487
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Leishmania major cytochrome p450-like protein 0.0012 0.0085 0.0505
Schistosoma mansoni biogenic amine receptor 0.0066 0.0897 0.3399
Loa Loa (eye worm) hypothetical protein 0.0036 0.0441 0.1661
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0897 0.0883
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0014 0.0121 0.0446
Schistosoma mansoni cyclin B3 0.0182 0.2636 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0146 0.1809
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0146 0.0884
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0015 0.0119
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0273 0.1614
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.012 0.0726
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0623 0.3803
Mycobacterium leprae Probable lipase LipE 0.0072 0.0983 0.5919
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0273 0.1675
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0121 0.0661
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0273 0.2755
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0012 0.0085 0.0125
Entamoeba histolytica cyclin, putative 0.0059 0.0791 0.485
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0015 0.0044
Entamoeba histolytica hypothetical protein 0.0014 0.0121 0.0661
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0024 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0897 0.0883
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0014 0.0121 0.0456
Brugia malayi pyruvate kinase 0.0008 0.002 0.0063
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0137 0.0123
Echinococcus granulosus dna polymerase eta 0.0021 0.0216 0.0201
Entamoeba histolytica cyclin family protein 0.0059 0.0791 0.485
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0085 0.007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0983 0.0969
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0024 0.0058
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0066 0.0897 0.3399
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0048 0.0623 0.3848
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0243 0.2445
Brugia malayi Cyclin, N-terminal domain containing protein 0.0014 0.0121 0.0446
Echinococcus granulosus G1:S specific cyclin D1 0.0014 0.0121 0.0106
Trypanosoma cruzi cyclin, putative 0.0114 0.1615 1
Echinococcus granulosus cyclin B3 1 0.0059 0.0791 0.0777
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0623 0.3803
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1475 0.893
Leishmania major DNA polymerase kappa, putative 0.0021 0.0216 0.132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Echinococcus multilocularis cyclins 0.0059 0.0791 0.0777
Plasmodium falciparum protein kinase 5 0.0048 0.0623 0.7873
Onchocerca volvulus 0.0066 0.0897 0.5511
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0595 0.0581
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0012 0.0085 0.0125
Brugia malayi putative neuropeptide receptor 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Echinococcus granulosus peptide allatostatin:somatostatin 0.0066 0.0897 0.0883
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0137 0.0123
Echinococcus multilocularis cyclin b3 0.0059 0.0791 0.0777
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0441 0.2715
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.0623 0.0609
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0015 0.0044
Plasmodium vivax protein kinase Crk2 0.0048 0.0623 0.6329
Echinococcus granulosus 7tm_1 domain containing protein 0.0066 0.0897 0.0883
Trypanosoma brucei cyclin 3 0.0014 0.0121 0.0729
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.165 0.2435
Onchocerca volvulus 0.0066 0.0897 0.5511
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0024 0.0009
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0015 0.0044
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0014 0.0121 0.1198
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0983 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0897 0.3399
Trypanosoma brucei mitotic cyclin 0.0014 0.0121 0.0729
Giardia lamblia CEGP1 protein 0.0013 0.0108 0.065
Toxoplasma gondii cyclin 4, putative 0.0014 0.0121 0.1198
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0015 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0897 0.0883
Leishmania major mitotic cyclin, putative 0.0014 0.0121 0.0729
Schistosoma mansoni growth hormone secretagogue receptor 0.0066 0.0897 0.3399
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0044
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0015 0.0072
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0121 0.0446
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0146 0.0884
Echinococcus granulosus fmrfamide receptor 0.0066 0.0897 0.0883
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0441 0.2715
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0146 0.1454
Echinococcus granulosus smad 0.0008 0.0026 0.0011
Trichomonas vaginalis cyclin B, putative 0.0014 0.0121 0.0661
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0983 0.145
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.0237
Brugia malayi Cyclin, N-terminal domain containing protein 0.0014 0.0121 0.0446
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0595 0.2247
Schistosoma mansoni amine GPCR 0.0066 0.0897 0.3399
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0273 0.1675
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0121 0.0446
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.0623 0.3803
Schistosoma mansoni amine GPCR 0.0066 0.0897 0.3399
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0121 0.0661
Leishmania major pyruvate kinase 0.0036 0.0441 0.2715
Brugia malayi sulfakinin receptor protein 0.0066 0.0897 0.3392
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0216 0.0201
Schistosoma mansoni cyclin B 0.0114 0.1615 0.6123
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0897 0.0883
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0572 0.0558
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0983 0.608
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0066 0.0897 0.0883
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0983 0.145
Schistosoma mansoni hypothetical protein 0.0015 0.0137 0.0519
Brugia malayi follicle stimulating hormone receptor 0.0066 0.0897 0.3392
Chlamydia trachomatis pyruvate kinase 0.0036 0.0441 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0146 0.0884
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0085 0.0309
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0623 0.2363
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0015 0.0055
Onchocerca volvulus 0.0024 0.0273 0.1614
Loa Loa (eye worm) cyclin domain-containing protein 0.0182 0.2636 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0216 0.0818
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0012 0.0085 0.0125
Brugia malayi RE15519p 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0012 0.0085 0.0125
Plasmodium falciparum cyclin 1 0.0014 0.0121 0.1491
Echinococcus multilocularis cyclin A3 4 0.0014 0.0121 0.0106
Schistosoma mansoni histamine h1 receptor 0.0066 0.0897 0.3399
Brugia malayi Tachykinin-like peptides receptor 99D 0.0066 0.0897 0.3392
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0066 0.0897 0.0883
Trypanosoma cruzi cyclin 6, putative 0.0114 0.1615 1
Plasmodium falciparum glutathione reductase 0.0016 0.0146 0.1809
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0572 0.2161
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0897 0.3392
Trichomonas vaginalis cyclin B, putative 0.0114 0.1615 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.165 0.2435
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0012 0.0085 0.083
Echinococcus multilocularis cyclin 0.0014 0.0121 0.0106
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0897 0.3399
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0897 0.3399
Echinococcus granulosus Smad4 0.0008 0.0026 0.0011
Brugia malayi glutathione reductase 0.0046 0.0595 0.2247
Loa Loa (eye worm) hypothetical protein 0.0015 0.0139 0.0517
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0066 0.0897 0.3399
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0114 0.1615 1
Trypanosoma brucei cdc2-related kinase 1 0.0048 0.0623 0.3848
Onchocerca volvulus 0.0072 0.0983 0.6051
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0015 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0983 0.6051
Echinococcus granulosus cyclin G2 0.0014 0.0121 0.0106
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0012 0.0085 0.083
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.012 0.0726
Trichomonas vaginalis cyclin A, putative 0.0114 0.1615 1
Schistosoma mansoni Cyclin fold protein 0.0014 0.0121 0.0456
Brugia malayi Cyclin, N-terminal domain containing protein 0.0014 0.0121 0.0446
Trichomonas vaginalis esterase, putative 0.0072 0.0983 0.6051
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0012 0.0085 0.083
Schistosoma mansoni smad1 5 8 and 0.0008 0.0026 0.0096
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0066 0.0897 0.0883
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.0623 0.0609
Brugia malayi Protein kinase domain containing protein 0.0016 0.0145 0.0538
Brugia malayi GCC2 and GCC3 family protein 0.0013 0.0108 0.0398
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0572 0.2161
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0015 0.0072
Toxoplasma gondii cyclin dependent kinase binding protein 0.0014 0.0121 0.1198
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0014 0.0121 0.0106
Giardia lamblia Pyruvate kinase 0.0018 0.0181 0.1104
Loa Loa (eye worm) hypothetical protein 0.0099 0.1385 0.5247
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0897 0.3399
Brugia malayi Dopamine receptor protein 1 0.0066 0.0897 0.3392
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0146 0.1454
Brugia malayi Cytochrome P450 family protein 0.0012 0.0085 0.0309
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0427 0.0413
Onchocerca volvulus 0.0066 0.0897 0.5511
Echinococcus granulosus cyclins 0.0059 0.0791 0.0777
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0066 0.0897 0.3392
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0026 0.0085
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0497 0.1876
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0441 0.2662
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0166 0.0245
Plasmodium falciparum cyclin 0.0059 0.0791 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Entamoeba histolytica protein kinase, putative 0.0014 0.0116 0.063
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0012 0.0085 0.0125
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0012 0.0085 0.083
Schistosoma mansoni neuropeptide receptor 0.0066 0.0897 0.3399
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0015 0.0072
Brugia malayi MH1 domain containing protein 0.0008 0.0026 0.0085
Brugia malayi GCC2 and GCC3 family protein 0.0013 0.0108 0.0398
Loa Loa (eye worm) hypothetical protein 0.0013 0.0108 0.0398
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0015 0.0119
Echinococcus granulosus orexin receptor type 2 0.0066 0.0897 0.0883
Brugia malayi Cyclin, N-terminal domain containing protein 0.0014 0.0121 0.0446
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0012 0.0085 0.083
Trichomonas vaginalis cyclins, putative 0.0059 0.0791 0.485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0897 0.3399
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0458 0.2772
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Trichomonas vaginalis cyclin B, putative 0.0114 0.1615 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0024 0.009
Onchocerca volvulus Cyclin L homolog 0.0014 0.0121 0.0661
Trichomonas vaginalis cyclin D, putative 0.0059 0.0791 0.485
Trypanosoma brucei mitotic cyclin 6 0.0114 0.1615 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0024 0.009
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0146 0.0551
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0078 0.0064
Echinococcus multilocularis orexin receptor type 2 0.0066 0.0897 0.0883
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0085 0.0505
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0003 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0623 0.2363
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0024 0.0009
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0146 0.1809
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Onchocerca volvulus 0.0072 0.0983 0.6051
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0015 0.0119
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0066 0.0897 0.3399
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0216 0.132
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0015 0.0022
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.1085 0.1071
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0216 0.0319
Onchocerca volvulus 0.0066 0.0897 0.5511
Plasmodium vivax glutathione reductase, putative 0.0046 0.0595 0.6039
Plasmodium falciparum thioredoxin reductase 0.0046 0.0595 0.7512
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0983 0.0969
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0015 0.0119
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0024 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0497 0.0483
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0024 0.009
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0146 0.1454
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0066 0.0897 0.3392
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Brugia malayi hypothetical protein 0.0014 0.0121 0.0446
Giardia lamblia Cyclin B-like protein 0.0014 0.0121 0.0729
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.0623 0.2355
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0897 0.3399
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0066 0.0897 0.3399
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1643 0.6227
Brugia malayi MH1 domain containing protein 0.0008 0.0026 0.0085
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0024 0.0079
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0983 1
Entamoeba histolytica cyclin, domain containing protein 0.0014 0.0121 0.0661
Loa Loa (eye worm) hypothetical protein 0.0072 0.0983 0.3721
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0216 0.0808
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0146 0.5
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0243 0.1487
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0015 0.0119
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0897 0.3399
Trypanosoma cruzi cyclin 9, putative 0.0014 0.0121 0.0729
Loa Loa (eye worm) hypothetical protein 0.0072 0.0983 0.3721
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Schistosoma mansoni cytochrome P450 0.0012 0.0085 0.0319
Echinococcus multilocularis G protein coupled receptor 139 0.0066 0.0897 0.0883
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0012 0.0085 0.0125
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0983 0.6051
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0012 0.0085 0.0125
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0897 0.3392
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0273 0.1025
Schistosoma mansoni cyclins 0.0059 0.0791 0.2998
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0441 0.1661
Echinococcus granulosus geminin 0.0165 0.2371 0.2359
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0273 0.1675
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0014 0.0121 0.1198
Schistosoma mansoni neuropeptide receptor 0.0066 0.0897 0.3399
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0273 0.1579
Echinococcus multilocularis cyclin B 0.0114 0.1615 0.1602
Echinococcus multilocularis sex peptide receptor 0.0066 0.0897 0.0883
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0181 0.1816
Schistosoma mansoni adenoreceptor 0.0066 0.0897 0.3399
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0121 0.0661
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0026 0.0011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0983 0.3721
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0121 0.0661
Loa Loa (eye worm) hypothetical protein 0.0024 0.0273 0.1025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0674
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0015 0.0072
Echinococcus granulosus neuropeptide s receptor 0.0066 0.0897 0.0883
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0273 0.1614
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0146 0.0884
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0066 0.0897 0.0883
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0015 0.0072
Brugia malayi Cyclin, N-terminal domain containing protein 0.0114 0.1615 0.6119
Brugia malayi cell division control protein 2 homolog 0.0048 0.0623 0.2355
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0273 0.1614
Echinococcus multilocularis geminin 0.0165 0.2371 0.2359
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0595 0.0581
Loa Loa (eye worm) hypothetical protein 0.0047 0.0616 0.2326
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1475 0.2177
Echinococcus granulosus neuropeptide receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) TK/EPH protein kinase 0.0072 0.0989 0.3744
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Conserved protein 0.0072 0.0983 0.145
Mycobacterium tuberculosis Conserved protein 0.0072 0.0983 0.145
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0983 0.5919
Schistosoma mansoni amine GPCR 0.0066 0.0897 0.3399
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0441 0.1661
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0012 0.0085 0.083
Echinococcus multilocularis Smad4 0.0008 0.0026 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0012 0.0085 0.0125
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0897 0.3399
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0279 0.1653
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0121 0.1198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0983 0.3727
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Giardia lamblia Hypothetical protein 0.0059 0.0791 0.4888
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1643 0.6227
Echinococcus multilocularis pyruvate kinase 0.0028 0.0328 0.0314
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0014 0.0121 0.0729
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0897 0.0883
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0012 0.0085 0.083
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0146 0.0541
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Schistosoma mansoni biogenic amine receptor 0.0066 0.0897 0.3399
Brugia malayi beta-lactamase 0.0072 0.0983 0.3721
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0509
Echinococcus multilocularis serotonin receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0121 0.0446
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0012 0.0085 0.0125
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0427 0.1619
Echinococcus multilocularis Cyclin L1 0.0014 0.0121 0.0106
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Onchocerca volvulus 0.0014 0.0121 0.0661
Trichomonas vaginalis cyclin B, putative 0.0059 0.0791 0.485
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0572 0.217
Echinococcus granulosus cyclin G2 0.0014 0.0121 0.0106
Loa Loa (eye worm) cytochrome P450 0.0012 0.0085 0.0309
Loa Loa (eye worm) hypothetical protein 0.0072 0.0983 0.3721
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.012 0.0726
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0674
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1475 0.2177
Echinococcus multilocularis cyclin y 0.0014 0.0121 0.0106
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0273 0.1579
Onchocerca volvulus 0.0013 0.0108 0.0582
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.165 0.2435
Loa Loa (eye worm) hypothetical protein 0.0072 0.0983 0.3721
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0146 0.0884
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0983 0.145
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0897 0.3399
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0273 0.0403
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0273 0.2755
Giardia lamblia Kinase, CMGC CDK 0.0048 0.0623 0.3848
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.1085 0.1071
Mycobacterium tuberculosis Conserved protein 0.0072 0.0983 0.145
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0078 0.0295
Echinococcus granulosus cyclins 0.0059 0.0791 0.0777
Brugia malayi Smad1 0.0008 0.0026 0.0085
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0066 0.0897 0.3392
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0066 0.0897 0.3399
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0078 0.0295
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0441 0.2604
Echinococcus multilocularis cyclin dependent kinase 5 0.0048 0.0623 0.0609
Echinococcus granulosus g protein coupled receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0066 0.0897 0.3392
Loa Loa (eye worm) Smad1 0.0008 0.0026 0.0085
Echinococcus granulosus pyruvate kinase 0.0018 0.0181 0.0167
Echinococcus multilocularis endonuclease reverse transcriptase 0.0013 0.0108 0.0093
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0024 0.0058
Entamoeba histolytica hypothetical protein 0.0035 0.0427 0.2578
Toxoplasma gondii hypothetical protein 0.0045 0.0578 0.5863
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0013 0.0108 0.1069
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0216 0.132
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.0623 0.2355
Echinococcus multilocularis dro:myosuppressin receptor 0.0066 0.0897 0.0883
Brugia malayi AKH receptor 0.0066 0.0897 0.3392
Plasmodium vivax cyclin 4, putative 0.0014 0.0121 0.1198
Brugia malayi Serotonin receptor 0.0066 0.0897 0.3392
Echinococcus granulosus dro:myosuppressin receptor 0.0066 0.0897 0.0883
Echinococcus multilocularis cyclins 0.0059 0.0791 0.0777
Entamoeba histolytica cyclin, domain containing protein 0.0014 0.0121 0.0661
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0441 0.4465
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0066 0.0897 0.0883
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0012 0.0085 0.0125
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0897 0.0883
Brugia malayi Death domain containing protein 0.0015 0.0137 0.0509
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0012 0.0085 0.083
Echinococcus multilocularis pyruvate kinase 0.0036 0.0441 0.0426
Toxoplasma gondii hypothetical protein 0.0013 0.0108 0.1069
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0108 0.1069
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Mycobacterium ulcerans beta-lactamase 0.0072 0.0983 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0216 0.132
Loa Loa (eye worm) beta-lactamase 0.0072 0.0983 0.3721
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0012 0.0085 0.083
Loa Loa (eye worm) hypothetical protein 0.0013 0.0108 0.0398
Echinococcus multilocularis cyclin B3 1 0.0059 0.0791 0.0777
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0181 0.2253
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0146 0.5
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0012 0.0085 0.0125
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0013 0.0108 0.1069
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0015 0.0119
Brugia malayi Cytochrome P450 family protein 0.0012 0.0085 0.0309
Onchocerca volvulus 0.0099 0.1385 0.8563
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0216 0.0201
Brugia malayi hypothetical protein 0.0014 0.0121 0.0446
Schistosoma mansoni hypothetical protein 0.0035 0.0427 0.1619
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0497 0.0483
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0983 0.6051
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0024 0.009
Trypanosoma cruzi mitotic cyclin, putative 0.0014 0.0121 0.0729
Echinococcus granulosus G protein coupled receptor 139 0.0066 0.0897 0.0883
Trichomonas vaginalis cyclins, putative 0.0114 0.1615 1
Onchocerca volvulus 0.0056 0.0749 0.459
Schistosoma mansoni alpha-1 adrenergic receptor 0.0066 0.0897 0.3399
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0273 0.1025
Brugia malayi hypothetical protein 0.0035 0.0427 0.161
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0897 0.0883
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0012 0.0085 0.083
Trypanosoma brucei unspecified product 0.0021 0.0216 0.132
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0497 0.1876
Entamoeba histolytica hypothetical protein 0.0013 0.0108 0.0582
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Echinococcus granulosus cyclins 0.0014 0.0121 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0015 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Loa Loa (eye worm) oxidoreductase 0.0007 0.0015 0.0044
Echinococcus granulosus pyruvate kinase 0.0036 0.0441 0.0426
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0015 0.0022
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.002 0.0063
Schistosoma mansoni cyclin G2 0.0014 0.0121 0.0456
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0015 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0983 0.608
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Schistosoma mansoni hypothetical protein 0.0066 0.0897 0.3399
Schistosoma mansoni cyclin l 0.0014 0.0121 0.0456
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0015 0.0119
Schistosoma mansoni hypothetical protein 0.0014 0.0121 0.0456
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0015 0.0022
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.1385 0.5252
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0674
Trypanosoma cruzi cyclin, putative 0.0114 0.1615 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0243 0.091
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0015 0.0119
Echinococcus multilocularis G1:S specific cyclin D1 0.0014 0.0121 0.0106
Onchocerca volvulus 0.0072 0.0983 0.6051
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0015 0.0119
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Echinococcus granulosus cyclin B 0.0114 0.1615 0.1602
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0012 0.0085 0.0125
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0015 0.0147
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0015 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0551 0.209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0146 0.0818
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0026 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0273 0.1025
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0983 0.6051
Echinococcus granulosus allatostatin A receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0072 0.0983 0.3721
Brugia malayi neuropeptide F receptor 0.0066 0.0897 0.3392
Onchocerca volvulus 0.0066 0.0897 0.5511
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0897 0.3399
Trichomonas vaginalis cyclin B3, putative 0.0014 0.0121 0.0661
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0216 0.132
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0066 0.0897 0.0883
Echinococcus granulosus endonuclease reverse transcriptase 0.0013 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0048 0.0623 0.2355
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Toxoplasma gondii hypothetical protein 0.0014 0.0121 0.1198
Echinococcus granulosus Ankyrin 0.0015 0.0139 0.0125
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0066 0.0897 0.3392
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0137 0.0509
Echinococcus multilocularis cyclin t1 0.0014 0.0121 0.0106
Brugia malayi Cyclin, N-terminal domain containing protein 0.0014 0.0121 0.0446
Echinococcus granulosus neuropeptide receptor A26 0.0066 0.0897 0.0883
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0048 0.0623 0.6329
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0015 0.0119
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Echinococcus multilocularis cyclins 0.0059 0.0791 0.0777
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0572 0.0558
Schistosoma mansoni cyclin G 0.0014 0.0121 0.0456
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0015 0.0044
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0012 0.0085 0.0505
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0146 0.0884
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0012 0.0085 0.083
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0012 0.0085 0.0125
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0015 0.0119
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0897 0.3399
Trichomonas vaginalis cyclin B, putative 0.0014 0.0121 0.0661
Trypanosoma cruzi mitotic cyclin, putative 0.0014 0.0121 0.0729
Trichomonas vaginalis cyclin D, putative 0.0014 0.0121 0.0661
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0897 0.0883
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0015 0.0072
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0048 0.0623 0.3848
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1475 0.2177
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0146 0.1454
Entamoeba histolytica cyclin C, putative 0.0014 0.0121 0.0661
Echinococcus multilocularis G-protein coupled receptor, putative 0.0066 0.0897 0.0883
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0024 0.0009
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0441 0.1661
Loa Loa (eye worm) hypothetical protein 0.0011 0.0078 0.0285
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0273 0.1025
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0066 0.0897 0.3392
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.0623 0.3848
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0674
Brugia malayi larval opioid receptor 0.0066 0.0897 0.3392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0146 0.0884
Schistosoma mansoni opsin-like receptor 0.0066 0.0897 0.3399
Plasmodium falciparum cysteine repeat modular protein 2 0.0013 0.0108 0.133
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0078 0.0064
Echinococcus granulosus cyclin dependent kinase 1 0.0048 0.0623 0.0609
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0085 0.0505
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0216 0.2171
Entamoeba histolytica hypothetical protein 0.0035 0.0427 0.2578
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0279 0.1049
Loa Loa (eye worm) cyclin C 0.0014 0.0121 0.0446
Onchocerca volvulus 0.0114 0.1615 1
Leishmania major trypanothione reductase 0.0046 0.0595 0.3671
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0181 0.1187
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0024 0.0009
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0014 0.0121 0.0106
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0014 0.0121 0.0106
Echinococcus granulosus cyclin 0.0014 0.0121 0.0106
Trichomonas vaginalis cyclin B3, putative 0.0059 0.0791 0.485
Echinococcus multilocularis cyclins 0.0059 0.0791 0.0777
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0273 0.2755
Loa Loa (eye worm) melatonin receptor type 1A 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0012 0.0085 0.0125
Onchocerca volvulus 0.0066 0.0897 0.5511
Onchocerca volvulus 0.0066 0.0897 0.5511
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0243 0.1487
Onchocerca volvulus 0.0066 0.0897 0.5511
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0216 0.0818
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0024 0.0009
Echinococcus granulosus cyclin dependent kinase 0.0048 0.0623 0.0609
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0983 0.6051
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0216 0.0808
Giardia lamblia Hypothetical protein 0.0013 0.0108 0.065
Schistosoma mansoni netrin receptor unc5 0.0015 0.0137 0.0519
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0066 0.0897 0.3392
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0897 0.0883
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0897 0.0883
Schistosoma mansoni hypothetical protein 0.0165 0.2371 0.8992
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0983 0.145
Plasmodium falciparum glutathione reductase 0.0046 0.0595 0.7512
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0026 0.0011
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0012 0.0085 0.0125
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0216 0.132
Trypanosoma brucei cyclin 9 0.0014 0.0121 0.0729
Trichomonas vaginalis cyclins, putative 0.0114 0.1615 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0166 0.0245
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Trichomonas vaginalis cyclin B, putative 0.0114 0.1615 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0013 0.0108 0.133
Trichomonas vaginalis cyclins, putative 0.0014 0.0121 0.0661
Brugia malayi ORL1-like opioid receptor 0.0066 0.0897 0.3392
Schistosoma mansoni smad 0.0008 0.0026 0.0096
Echinococcus granulosus neuropeptide FF receptor 2 0.0066 0.0897 0.0883
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0572 0.217
Echinococcus granulosus cyclin y 0.0014 0.0121 0.0106
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Brugia malayi cytochrome P450 0.0012 0.0085 0.0309
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0458 0.2772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0897 0.3399
Echinococcus granulosus cyclin k 0.0014 0.0121 0.0106
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0014 0.0121 0.0446
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0551 0.209
Schistosoma mansoni hypothetical protein 0.0066 0.0897 0.3399
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0066 0.0897 0.3399
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) hypothetical protein 0.0024 0.0273 0.1025
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0015 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0012 0.0085 0.0125
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Echinococcus granulosus tachykinin peptides receptor 99D 0.0066 0.0897 0.0883
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0273 0.2755
Leishmania major cytochrome p450-like protein 0.0012 0.0085 0.0505
Echinococcus granulosus cyclin b3 0.0059 0.0791 0.0777
Echinococcus granulosus cyclin dependent kinase 5 0.0048 0.0623 0.0609
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0121 0.0446
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0441 0.2715
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0897 0.3399
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.0623 0.3848
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0015 0.0119
Brugia malayi Uncoordinated protein 44 0.0015 0.0137 0.0509
Schistosoma mansoni opsin-like receptor 0.0066 0.0897 0.3399
Brugia malayi cyclin fold protein 1 variant b 0.0014 0.0121 0.0446
Plasmodium falciparum pyruvate kinase 0.0036 0.0441 0.5555
Echinococcus multilocularis pyruvate kinase 0.0036 0.0441 0.0426
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0078 0.0064
Brugia malayi Thioredoxin reductase 0.0046 0.0595 0.2247
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0897 0.0883
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0216 0.2171
Onchocerca volvulus Cyclin L homolog 0.0014 0.0121 0.0661
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0897 0.0883
Trypanosoma brucei unspecified product 0.0014 0.012 0.0726
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0015 0.0044
Entamoeba histolytica hypothetical protein 0.0035 0.0427 0.2578
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1475 0.2177
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0441 0.1661
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0273 0.2755
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0983 0.145
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0897 0.0883
Giardia lamblia Hypothetical protein 0.0014 0.0121 0.0729
Leishmania major pyruvate kinase 0.0036 0.0441 0.2715
Schistosoma mansoni hypothetical protein 0.0066 0.0897 0.3399
Brugia malayi Cyclin C 0.0014 0.0121 0.0446
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0897 0.3399
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0146 0.1454
Brugia malayi GnHR receptor homolog 0.0066 0.0897 0.3392
Brugia malayi Cyclin, N-terminal domain containing protein 0.0182 0.2636 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0083 0.0301
Brugia malayi GCC2 and GCC3 family protein 0.0013 0.0108 0.0398
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0595 0.3671
Echinococcus multilocularis cyclin y 0.0014 0.0121 0.0106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0108 0.0398
Mycobacterium leprae Conserved hypothetical protein 0.0012 0.0085 0.0426
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.0623 0.3848
Echinococcus granulosus cyclin y 0.0014 0.0121 0.0106
Schistosoma mansoni DNA polymerase eta 0.0021 0.0216 0.0818
Onchocerca volvulus 0.0066 0.0897 0.5511
Mycobacterium tuberculosis Probable reductase 0.0105 0.1475 0.2177
Leishmania major cyclin 0.0114 0.1615 1
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0983 0.145
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0146 0.0131
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.0108 0.0582
Entamoeba histolytica hypothetical protein 0.0013 0.0108 0.0582
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0015 0.0072
Brugia malayi beta-lactamase family protein 0.0072 0.0983 0.3721
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0791 0.485
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0012 0.0085 0.083
Toxoplasma gondii GCC2 and GCC3 domain-containing protein 0.0013 0.0108 0.1069
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0146 0.0884
Leishmania major cyclin 9, putative 0.0014 0.0121 0.0729
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0146 0.1454
Onchocerca volvulus 0.0066 0.0897 0.5511
Trypanosoma brucei trypanothione reductase 0.0046 0.0595 0.3671
Echinococcus multilocularis neuropeptide s receptor 0.0066 0.0897 0.0883
Echinococcus granulosus hypothetical protein 0.0066 0.0897 0.0883
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0066 0.0897 0.3399
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0166 0.0245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0166 0.0245
Leishmania major cytochrome p450-like protein 0.0022 0.0243 0.1487
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0026 0.0085
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0216 0.1257
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Brugia malayi Dopamine receptor protein 2 0.0066 0.0897 0.3392
Giardia lamblia Hypothetical protein 0.0014 0.0121 0.0729
Schistosoma mansoni pyruvate kinase 0.0036 0.0441 0.167
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0273 0.2755
Loa Loa (eye worm) hypothetical protein 0.0014 0.0121 0.0446
Schistosoma mansoni hypothetical protein 0.0014 0.0121 0.0456
Schistosoma mansoni biogenic amine receptor 0.0066 0.0897 0.3399
Brugia malayi Cyclin, N-terminal domain containing protein 0.0014 0.0121 0.0446
Echinococcus granulosus g-protein coupled receptor 0.0066 0.0897 0.0883
Echinococcus granulosus cyclin t1 0.0014 0.0121 0.0106
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0137 0.0509
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0012 0.0085 0.083
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0012 0.0085 0.0125
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0216 0.0201
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0181 0.1811
Treponema pallidum NADH oxidase 0.0016 0.0146 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0243 0.091
Brugia malayi MH2 domain containing protein 0.0116 0.1643 0.6227
Brugia malayi G protein-coupled receptor F59B2.13 0.0066 0.0897 0.3392
Echinococcus multilocularis pyruvate kinase 0.0018 0.0181 0.0167
Schistosoma mansoni opsin-like receptor 0.0066 0.0897 0.3399
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0024 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Schistosoma mansoni neuropeptide f receptor 76f 0.0066 0.0897 0.3399
Plasmodium falciparum cysteine repeat modular protein 4 0.0013 0.0108 0.133
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0216 0.132
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0146 0.0884
Echinococcus granulosus alpha 1A adrenergic receptor 0.0066 0.0897 0.0883
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0015 0.0119
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0572 0.0558
Trichomonas vaginalis cyclin A, putative 0.0014 0.0121 0.0661
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0146 0.0884
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0015 0.0119
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0983 0.3721
Echinococcus multilocularis cyclins 0.0059 0.0791 0.0777
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0216 0.1257
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Toxoplasma gondii thioredoxin reductase 0.0046 0.0595 0.6039
Trypanosoma brucei cdc2-related kinase 3 0.0048 0.0623 0.3848
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0012 0.0085 0.083
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0441 0.2662
Giardia lamblia Cyclin fold protein 1, putative 0.0014 0.0121 0.0729
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0441 0.1661
Brugia malayi G-protein coupled receptor 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Schistosoma mansoni pyruvate kinase 0.0018 0.0181 0.0686
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0066 0.0897 0.3392
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Schistosoma mansoni cyclin d 0.0014 0.0121 0.0456
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0012 0.0085 0.083
Schistosoma mansoni pyruvate kinase 0.0036 0.0441 0.167
Echinococcus granulosus pyruvate kinase 0.0036 0.0441 0.0426
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0897 0.0883
Leishmania major DNA polymerase eta, putative 0.0021 0.0216 0.132
Loa Loa (eye worm) cyclin domain-containing protein 0.0014 0.0121 0.0446
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0216 0.132
Echinococcus multilocularis cyclin dependent kinase 0.0048 0.0623 0.0609
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0015 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0897 0.0883
Onchocerca volvulus 0.0066 0.0897 0.5511
Echinococcus granulosus dna polymerase kappa 0.0021 0.0216 0.0201
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0216 0.132
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0048 0.0623 0.0609
Plasmodium vivax cyclin homologue, putative 0.0014 0.0121 0.1198
Trichomonas vaginalis cyclins, putative 0.0114 0.1615 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0897 0.3399
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0146 0.0884
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0595 0.6039
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Loa Loa (eye worm) hypothetical protein 0.0021 0.0216 0.0808
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0146 0.0884
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0181 0.0267
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0146 0.0884
Echinococcus granulosus pyruvate kinase 0.0018 0.0181 0.0167
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0983 1
Trichomonas vaginalis cyclin D, putative 0.0059 0.0791 0.485
Echinococcus multilocularis g-protein coupled receptor 0.0066 0.0897 0.0883
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0182 0.2636 0.2625
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0983 0.3727
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0441 0.2662
Echinococcus granulosus cyclins 0.0059 0.0791 0.0777
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) TYRA-2 protein 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0674
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0108 0.1069
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0066 0.0897 0.0883
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0121 0.1491
Loa Loa (eye worm) hypothetical protein 0.0056 0.0749 0.2832
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1475 0.2177
Echinococcus multilocularis cyclins 0.0059 0.0791 0.0777
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0572 0.217
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0121 0.0729
Schistosoma mansoni g1/s-specific cyclin C 0.0014 0.0121 0.0456
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0024 0.0009
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0012 0.0085 0.083
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0623 0.3803
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0273 0.0403
Trypanosoma brucei unspecified product 0.0014 0.012 0.0726
Schistosoma mansoni hypothetical protein 0.0165 0.2371 0.8992
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0216 0.0319
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0146 0.0818
Trichomonas vaginalis cyclin B3, putative 0.0014 0.0121 0.0661
Schistosoma mansoni Smad4 0.0008 0.0026 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0015 0.0119
Brugia malayi neuropeptide F receptor 0.0066 0.0897 0.3392
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0897 0.3392
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0024 0.009
Schistosoma mansoni neuropeptide receptor 0.0066 0.0897 0.3399
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0181 0.1811
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Onchocerca volvulus 0.0066 0.0897 0.5511
Echinococcus multilocularis pyruvate kinase 0.0018 0.0181 0.0167
Echinococcus granulosus serotonin receptor 0.0066 0.0897 0.0883
Echinococcus granulosus g protein coupled receptor 0.0066 0.0897 0.0883
Onchocerca volvulus 0.0066 0.0897 0.5511
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0897 0.0883
Echinococcus granulosus cyclin A3 4 0.0014 0.0121 0.0106
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0146 0.0884
Brugia malayi GCC2 and GCC3 family protein 0.0013 0.0108 0.0398
Brugia malayi Dopamine receptor 0.0066 0.0897 0.3392
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0181 0.1816
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0012 0.0085 0.0505
Entamoeba histolytica cysteine-rich surface protein, putative 0.0013 0.0108 0.0582
Plasmodium falciparum thioredoxin reductase 0.0016 0.0146 0.1809
Loa Loa (eye worm) hypothetical protein 0.0072 0.0983 0.3721
Giardia lamblia Cyclin A 0.0059 0.0791 0.4888
Brugia malayi Melatonin receptor type 1A 0.0066 0.0897 0.3392
Plasmodium falciparum conserved protein, unknown function 0.0013 0.0108 0.133
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0182 0.2636 0.2625
Schistosoma mansoni neuropeptide receptor 0.0066 0.0897 0.3399
Trichomonas vaginalis cyclins, putative 0.0014 0.0121 0.0661
Entamoeba histolytica cyclin, putative 0.0114 0.1615 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0066 0.0897 0.0883
Mycobacterium ulcerans hypothetical protein 0.0024 0.0273 0.2755
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0216 0.132
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0024 0.0009
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0066 0.0897 0.3392
Giardia lamblia Pyruvate kinase 0.0036 0.0441 0.2715
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0012 0.0085 0.083
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0014 0.0121 0.1198
Loa Loa (eye worm) hypothetical protein 0.0013 0.0108 0.0398
Brugia malayi G protein-coupled receptor 0.0066 0.0897 0.3392
Brugia malayi MH2 domain containing protein 0.0008 0.0026 0.0085
Echinococcus multilocularis cyclin G2 0.0014 0.0121 0.0106
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0139 0.0527
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0441 0.2662
Brugia malayi G-protein coupled receptor 0.0066 0.0897 0.3392
Echinococcus multilocularis serotonin receptor 0.0066 0.0897 0.0883
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0243 0.091
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0441 0.2715
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Echinococcus granulosus cyclins 0.0059 0.0791 0.0777
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0897 0.0883
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0026 0.0011
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0897 0.0883
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0015 0.0119
Schistosoma mansoni hypothetical protein 0.0012 0.0085 0.0319
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0012 0.0085 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0015 0.0044
Echinococcus multilocularis 0.0012 0.0085 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Trichomonas vaginalis cyclins, putative 0.0069 0.0944 0.5811
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0897 0.0883
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.1049
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0897 0.3399
Loa Loa (eye worm) glutathione reductase 0.0046 0.0595 0.2247
Echinococcus multilocularis cyclins 0.0059 0.0791 0.0777
Echinococcus multilocularis neuropeptide receptor A26 0.0066 0.0897 0.0883
Echinococcus granulosus sex peptide receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) CYL-1 protein 0.0014 0.0121 0.0446
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0083 0.0301
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0079
Echinococcus multilocularis allatostatin A receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) pyruvate kinase 0.0008 0.002 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0572 0.0558
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0024 0.0079
Brugia malayi Cytochrome P450 family protein 0.0022 0.0243 0.091
Loa Loa (eye worm) hypothetical protein 0.0114 0.1615 0.6119
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0013 0.0108 0.1069
Echinococcus multilocularis smad 0.0008 0.0026 0.0011
Plasmodium falciparum cysteine repeat modular protein 3 0.0013 0.0108 0.133
Echinococcus granulosus neuropeptide receptor 0.0066 0.0897 0.0883
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0024 0.0009
Mycobacterium leprae putative cytochrome p450 0.0012 0.0085 0.0426
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0024 0.0009
Trichomonas vaginalis cyclin B, putative 0.0114 0.1615 1
Onchocerca volvulus 0.0066 0.0897 0.5511
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0441 0.4465
Schistosoma mansoni hypothetical protein 0.0013 0.0108 0.0408
Onchocerca volvulus Protein CNPPD1 homolog 0.0014 0.0121 0.0661
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0181 0.2259
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0015 0.0119
Entamoeba histolytica hypothetical protein 0.0035 0.0427 0.2578
Brugia malayi Serotonin receptor 0.0066 0.0897 0.3392
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0146 0.0884
Echinococcus multilocularis dna polymerase eta 0.0021 0.0216 0.0201
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0137 0.0123
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0146 0.1454
Brugia malayi Cyclin, N-terminal domain containing protein 0.0114 0.1615 0.6119
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0012 0.0085 0.0125
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0066 0.0897 0.5511
Brugia malayi hypothetical protein 0.0066 0.0897 0.3392
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0014 0.0121 0.1491
Schistosoma mansoni amine GPCR 0.0066 0.0897 0.3399
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0441 0.4465
Loa Loa (eye worm) hypothetical protein 0.0055 0.0731 0.2765
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0146 0.0884
Schistosoma mansoni hypothetical protein 0.0066 0.0897 0.3399
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0012 0.0085 0.083
Onchocerca volvulus Neuropeptide F receptor homolog 0.0066 0.0897 0.5511
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0216 0.0808
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0897 0.0883
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0146 0.0215
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0012 0.0085 0.083
Leishmania major mitotic cyclin, putative 0.0014 0.0121 0.0729
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.0623 0.3848
Echinococcus granulosus death domain containing protein 0.0015 0.0137 0.0123
Echinococcus granulosus 7TM GPCR rhodopsin 0.0066 0.0897 0.0883
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0012 0.0085 0.083
Echinococcus multilocularis tumor protein p63 0.0675 1 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0181 0.0167
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0078 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0897 0.0883
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0026 0.0096
Giardia lamblia DINP protein human, muc B family 0.0021 0.0216 0.132
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0897 0.0883
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.6778 1
Onchocerca volvulus 0.0066 0.0897 0.5511
Loa Loa (eye worm) hypothetical protein 0.0029 0.0336 0.1263
Trichomonas vaginalis cyclins, putative 0.0114 0.1615 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.165 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0441 0.065
Echinococcus granulosus pyruvate kinase 0.0018 0.0181 0.0167
Toxoplasma gondii cytochrome p450 superfamily protein 0.0012 0.0085 0.083
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0015 0.0044
Brugia malayi MH2 domain containing protein 0.0008 0.0026 0.0085
Brugia malayi ephrin receptor 1 precursor 0.0027 0.0313 0.1178
Echinococcus multilocularis ephrin type A receptor 4 A 0.007 0.0959 0.0945
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0595 0.0878
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0014 0.0121 0.0106
Echinococcus granulosus cyclins 0.0059 0.0791 0.0777
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0015 0.0072
Echinococcus multilocularis neuropeptide FF receptor 2 0.0066 0.0897 0.0883
Echinococcus multilocularis cyclin k 0.0014 0.0121 0.0106
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Brugia malayi putative neuropeptide receptor NPR1 0.0066 0.0897 0.3392
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0015 0.0072
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0015 0.0022
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0137 0.0123
Giardia lamblia Kinase, CMGC CDK 0.0048 0.0623 0.3848
Echinococcus granulosus somatostatin receptor 0.0066 0.0897 0.0883
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0897 0.3399
Echinococcus multilocularis Ankyrin 0.0015 0.0139 0.0125
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0066 0.0897 0.3399
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0015 0.0022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0216 0.132
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0897 0.0883
Schistosoma mansoni smad1 5 8 and 0.0008 0.0026 0.0096
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0897 0.0883
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0983 0.145
Leishmania major hypothetical protein, conserved 0.0072 0.0983 0.608
Mycobacterium ulcerans lipase LipD 0.0072 0.0983 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0146 0.0131
Brugia malayi beta-lactamase family protein 0.0072 0.0983 0.3721
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0137 0.0765
Giardia lamblia G2/mitotic-specific cyclin B 0.0114 0.1615 1
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0983 0.608
Schistosoma mansoni cyclin k 0.0014 0.0121 0.0456
Trypanosoma cruzi CYC2-like cyclin, putative 0.0114 0.1615 1
Echinococcus granulosus g protein coupled receptor 0.0066 0.0897 0.0883
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0012 0.0085 0.0125
Echinococcus granulosus Cyclin L1 0.0014 0.0121 0.0106
Onchocerca volvulus 0.0013 0.0108 0.0582
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0066 0.0897 0.0883
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0015 0.0119
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0015 0.0119
Schistosoma mansoni amine GPCR 0.0066 0.0897 0.3399
Brugia malayi Cytochrome P450 family protein 0.0022 0.0243 0.091
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0897 0.0883
Onchocerca volvulus 0.0066 0.0897 0.5511
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0216 0.1257
Brugia malayi Cyclin, N-terminal domain containing protein 0.0014 0.0121 0.0446
Loa Loa (eye worm) hypothetical protein 0.0034 0.0419 0.158
Toxoplasma gondii ABC1 family protein 0.0072 0.0983 1
Echinococcus multilocularis somatostatin receptor 0.0066 0.0897 0.0883
Onchocerca volvulus 0.0066 0.0897 0.5511
Schistosoma mansoni smad1 5 8 and 0.0008 0.0026 0.0096
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0441 0.2662
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0216 0.132
Echinococcus multilocularis cyclin G2 0.0014 0.0121 0.0106
Toxoplasma gondii kringle domain-containing protein 0.0013 0.0108 0.1069
Loa Loa (eye worm) hypothetical protein 0.0066 0.0897 0.3392
Schistosoma mansoni ephrin receptor 0.0057 0.0758 0.2875

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 5 uM Antiproliferative activity against human HaCaT cells ChEMBL. 10395495
IC50 (binding) = 36 uM Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1 ChEMBL. 9083483
IC50 (binding) = 36 uM Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1 ChEMBL. 9083483
IC50 (binding) = 44 uM Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2 ChEMBL. 9083483
IC50 (binding) = 44 uM Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2 ChEMBL. 9083483
IC50 (binding) = 61 uM Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1 ChEMBL. 9083483
IC50 (binding) = 61 uM Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1 ChEMBL. 9083483
IC50 (binding) = 62.4 uM Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2 ChEMBL. 9083483
IC50 (binding) = 62.4 uM Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2 ChEMBL. 9083483
IC50 (binding) = 63.5 uM Inhibition of PTP1B ChEMBL. 19362837
IC50 (binding) = 128 uM Inhibitory concentration of compound against disintegration (reversal of strand transfer)of HIV-1 integrase ChEMBL. 9083483
IC50 (binding) = 128 uM Inhibitory concentration of compound against disintegration (reversal of strand transfer)of HIV-1 integrase ChEMBL. 9083483
Inhibition (binding) = 76.9 % Percentage inhibition against strand transfer of HIV-1 integrase at 100 microg/mL ChEMBL. 9083483
Inhibition (binding) = 76.9 % Percentage inhibition against strand transfer of HIV-1 integrase at 100 microg/mL ChEMBL. 9083483
Inhibition (binding) = 94.7 % Percentage inhibition of compound against 3'-processing of HIV-1 integrase at 100 microg/mL ChEMBL. 9083483
Inhibition (binding) = 94.7 % Percentage inhibition of compound against 3'-processing of HIV-1 integrase at 100 microg/mL ChEMBL. 9083483
Inhibition (ADMET) = 109.7010212 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 122.9033244 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10395495

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.