Detailed information for compound 319563

Basic information

Technical information
  • TDR Targets ID: 319563
  • Name: (1S,2S)-1-N-methyl-1-N-[[4-(2-sulfamoylphenyl )phenyl]methyl]-2-N-[[4-(trifluoromethoxy)phe nyl]methyl]cyclopentane-1,2-dicarboxamide
  • MW: 589.626 | Formula: C29H30F3N3O5S
  • H donors: 2 H acceptors: 4 LogP: 4.36 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@H]1CCC[C@@H]1C(=O)N(Cc1ccc(cc1)c1ccccc1S(=O)(=O)N)C)NCc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C29H30F3N3O5S/c1-35(18-20-9-13-21(14-10-20)23-5-2-3-8-26(23)41(33,38)39)28(37)25-7-4-6-24(25)27(36)34-17-19-11-15-22(16-12-19)40-29(30,31)32/h2-3,5,8-16,24-25H,4,6-7,17-18H2,1H3,(H,34,36)(H2,33,38,39)/t24-,25-/m0/s1
  • InChiKey: KHYNGGVKOMNOKG-DQEYMECFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (1S,2S)-N1-methyl-N1-[[4-(2-sulfamoylphenyl)phenyl]methyl]-N2-[[4-(trifluoromethoxy)phenyl]methyl]cyclopentane-1,2-dicarboxamide
  • (1S,2S)-N-methyl-N-[4-(2-sulfamoylphenyl)benzyl]-N'-[4-(trifluoromethoxy)benzyl]cyclopentane-1,2-dicarboxamide
  • (1S,2S)-N-methyl-N-[[4-(2-sulfamoylphenyl)phenyl]methyl]-N'-[[4-(trifluoromethoxy)phenyl]methyl]cyclopentane-1,2-dicarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0476
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0035 0.0122 0.01
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.021
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0001 0.0001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0119 0.0515 0.2585
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.01 0.0132
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0301 0.1356 0.1355
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Brugia malayi ecdysteroid receptor 0.003 0.01 0.021
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0109 0.0169
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.0171 0.0438
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0406 0.0785
Echinococcus granulosus dnaJ subfamily B 0.0417 0.1893 0.2938
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0007 0.0016
Schistosoma mansoni neuropeptide receptor 0.0032 0.0109 0.0169
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0027 0.0052
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0144 0.115
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0009 0.0005 0.0008
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0054 0.0053
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0181 0.0802 0.1736
Toxoplasma gondii patched family protein 0.0012 0.0018 0.0017
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0263 0.118 0.1557
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Onchocerca volvulus 0.0032 0.0109 0.0995
Brugia malayi tailless protein 0.0014 0.0027 0.0052
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0035 0.0046
Brugia malayi neuropeptide F receptor 0.0032 0.0109 0.0231
Loa Loa (eye worm) histone deacetylase 3 0.0277 0.1245 0.2698
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0054 0.0249
Loa Loa (eye worm) hypothetical protein 0.0118 0.0507 0.1095
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.047 0.0726
Schistosoma mansoni DNA polymerase IV / kappa 0.0029 0.0095 0.0146
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.1142 0.2473
Loa Loa (eye worm) DR-78 0.0014 0.0027 0.0052
Giardia lamblia DNA damage repair protein 0.0029 0.0095 0.0498
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0027 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0109 0.017
Leishmania major importin beta-1 subunit, putative 0.0024 0.0072 0.0183
Loa Loa (eye worm) hypothetical protein 0.0194 0.0863 0.1867
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0109 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0191 0.0942
Brugia malayi hypothetical protein 0.0152 0.0668 0.1443
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0023 0.0055
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0012 0.0017
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0137 0.035
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0008 0.0012
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0171 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0178 0.0789 0.1224
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.0887 0.1919
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0009 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0081 0.008
Schistosoma mansoni terminal deoxycytidyl transferase 0.0092 0.039 0.0605
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0171 0.0924
Echinococcus granulosus casein kinase ii subunit beta 0.0037 0.0133 0.0206
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Echinococcus granulosus histone deacetylase 1 0.0277 0.1245 0.1932
Echinococcus multilocularis Immunoglobulin 0.0016 0.0035 0.0046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0335 0.0721
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.01 0.0155
Brugia malayi hypothetical protein 0.0016 0.0035 0.0069
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0109 0.0144
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0009 0.0005 0.0032
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.005 0.0389
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0098 0.0249
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0171 0.0366
Trypanosoma brucei histone deacetylase 4 0.0325 0.1467 0.377
Trichomonas vaginalis histone deacetylase, putative 0.0277 0.1245 0.6294
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Echinococcus multilocularis alkaline phosphatase 0.0164 0.0721 0.0952
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Echinococcus granulosus Protein patched homolog 1 0.0434 0.1976 0.3066
Schistosoma mansoni DNA helicase recq5 0.002 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0188 0.0833 0.1803
Brugia malayi TAR-binding protein 0.0076 0.0313 0.0674
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0109 0.017
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0181 0.0802 0.206
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0009 0.0005 0.0007
Onchocerca volvulus 0.0032 0.0109 0.0995
Echinococcus granulosus histone deacetylase 6 0.0331 0.1496 0.2322
Loa Loa (eye worm) hypothetical protein 0.0452 0.2058 0.4462
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0122 0.01
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0109 0.0169
Trypanosoma brucei histone deacetylase 2 0.0137 0.0596 0.1529
Giardia lamblia Casein kinase II beta chain 0.0037 0.0133 0.0709
Loa Loa (eye worm) hypothetical protein 0.0118 0.0509 0.11
Onchocerca volvulus 0.0012 0.0018 0.0139
Schistosoma mansoni acetyl-CoA synthetase 0.0035 0.0122 0.0188
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0054 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0244 0.0378
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0054 0.0137
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0362 0.0694
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0012 0.0018
Echinococcus multilocularis sterol regulatory element binding protein 0.0434 0.1976 0.2607
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0144 0.0773
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0109 0.0144
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0062 0.0128
Leishmania major hypothetical protein, conserved 0.0016 0.0035 0.0087
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0099 0.0098
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0104 0.0137
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0035 0.0087
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0009 0.0005 0.001
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0007 0.0002
Plasmodium falciparum histone deacetylase, putative 0.0325 0.1467 0.1466
Leishmania major trypanothione reductase 0.0038 0.0137 0.035
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0144 0.0143
Schistosoma mansoni hypothetical protein 0.0032 0.0109 0.0169
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0109 0.0231
Onchocerca volvulus 0.0032 0.0109 0.0995
Plasmodium vivax acetyl-CoA synthetase, putative 0.0035 0.0122 0.0117
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0106 0.0452 0.1159
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0062 0.0082
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0049 0.0191 0.0144
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0349 0.046
Loa Loa (eye worm) hypothetical protein 0.0407 0.185 0.401
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0007 0.001
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0009 0.0002 0.0001
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0171 0.0366
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0122 0.0203
Onchocerca volvulus 0.0069 0.0281 0.26
Plasmodium falciparum DNA repair protein REV1, putative 0.0029 0.0095 0.0094
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0035 0.0122 0.0121
Echinococcus multilocularis epidermal growth factor receptor 0.0539 0.2461 0.3247
Brugia malayi jmjC domain containing protein 0.0061 0.0244 0.0524
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.005 0.0506
Brugia malayi RE15519p 0.0032 0.0109 0.0231
Brugia malayi 6-phosphofructokinase 0.011 0.047 0.1013
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0035 0.0053
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0023 0.0021
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0012 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0067 0.014
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0136 0.0212
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0009 0.0005 0.0004
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0006 0.0007
Brugia malayi hypothetical protein 0.0026 0.0081 0.0169
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.047 0.0448
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0122 0.031
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0288 0.0738
Schistosoma mansoni amine GPCR 0.0032 0.0109 0.0169
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0109 0.0169
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0027 0.0223
Trichomonas vaginalis DNA polymerase eta, putative 0.0119 0.0515 0.2585
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0012 0.0017
Toxoplasma gondii hypothetical protein 0.0049 0.0188 0.0186
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0109 0.0144
Echinococcus granulosus g protein coupled receptor 0.0032 0.0109 0.017
Onchocerca volvulus 0.0032 0.0109 0.0995
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Entamoeba histolytica acyl-CoA synthetase, putative 0.0118 0.0507 0.4067
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0109 0.0144
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0011 0.0012 0.0033
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0003 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0162 0.025
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0237 0.0312
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0054 0.0137
Schistosoma mansoni cpg binding protein 0.0031 0.0105 0.0162
Loa Loa (eye worm) RecQ helicase 0.002 0.0054 0.0112
Echinococcus granulosus insulin receptor 0.0321 0.1451 0.2251
Echinococcus multilocularis replication factor c subunit 1 0.0049 0.0191 0.0252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0054 0.0273
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0109 0.0169
Plasmodium falciparum protein kinase 5 0.0045 0.0171 0.017
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0009 0.0005 0.0007
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0171 0.1368
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) Csnk2b protein 0.0037 0.0133 0.0282
Plasmodium vivax exonuclease I, putative 0.0011 0.0011 0.0006
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0109 0.0231
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0009 0.0005 0.0004
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0109 0.0144
Loa Loa (eye worm) carboxylesterase 0.0069 0.0281 0.0603
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0108 0.0107
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0624 0.1603
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0012 0.0017
Leishmania major DNA damage repair protein, putative 0.0029 0.0095 0.0241
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.0515 0.132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.01 0.021
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0117 0.0504 0.0483
Trichomonas vaginalis histone deacetylase, putative 0.0277 0.1245 0.6294
Schistosoma mansoni topbp1 0.0049 0.0191 0.0295
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0035 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0519 0.1122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.0132
Schistosoma mansoni hypothetical protein 0.0083 0.0349 0.054
Schistosoma mansoni dishevelled 0.0009 0.0003 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0486
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0335 0.0721
Toxoplasma gondii hypothetical protein 0.0009 0.0003 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.01 0.021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0104 0.0161
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0018
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0109 0.0231
Loa Loa (eye worm) hypothetical protein 0.0134 0.0581 0.1255
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0049 0.0191 0.019
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0035 0.0122 0.0203
Entamoeba histolytica exonuclease, putative 0.0011 0.0011 0.0081
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Entamoeba histolytica exonuclease, putative 0.0011 0.0011 0.0081
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0035 0.0069
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Trichomonas vaginalis flap endonuclease-1, putative 0.0053 0.0205 0.1016
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0104 0.0103
Brugia malayi Carboxylesterase family protein 0.0407 0.185 0.401
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0281 0.0435
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.0155
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0023 0.0188
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Onchocerca volvulus 0.0012 0.0018 0.0139
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0118 0.0507 0.0486
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0171 0.0924
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Schistosoma mansoni ap endonuclease 0.0019 0.005 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.0802 0.1244
Loa Loa (eye worm) hypothetical protein 0.0069 0.0281 0.0603
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0109 0.0144
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0136 0.0211
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0012 0.0018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0699 0.1384
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0092 0.039 0.0605
Mycobacterium ulcerans hypothetical protein 0.0118 0.0507 0.0486
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.005 0.0125
Schistosoma mansoni topbp1 0.0049 0.0191 0.0295
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.005 0.0225
Onchocerca volvulus 0.0032 0.0109 0.0995
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.005 0.0065
Brugia malayi hypothetical protein 0.0043 0.0162 0.0344
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0161 0.0156
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0171 0.0226
Brugia malayi Muscleblind-like protein 0.0452 0.2058 0.4462
Loa Loa (eye worm) carboxylesterase 0.0407 0.185 0.401
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0171 0.017
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0011 0.001
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0398 0.1804 0.9131
Loa Loa (eye worm) hypothetical protein 0.0038 0.0136 0.029
Schistosoma mansoni exonuclease 0.0011 0.0011 0.0017
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.1068 0.4912 1
Brugia malayi Csnk2b protein 0.0037 0.0133 0.0282
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Toxoplasma gondii patched family protein 0.0012 0.0018 0.0017
Echinococcus multilocularis protein patched 0.0434 0.1976 0.2607
Mycobacterium ulcerans DNA polymerase IV 0.0119 0.0515 0.0493
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0122 0.031
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0003 0.0004
Schistosoma mansoni tyrosine kinase 0.1002 0.4608 0.715
Loa Loa (eye worm) hypothetical protein 0.018 0.0796 0.1722
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0108 0.0276
Echinococcus granulosus neuropeptide receptor 0.0032 0.0109 0.017
Echinococcus granulosus sodium channel protein 0.0106 0.0452 0.0701
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0109 0.0144
Brugia malayi Protein kinase domain containing protein 0.0045 0.0171 0.0366
Onchocerca volvulus 0.0032 0.0109 0.0995
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0083 0.0347 0.0664
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.047 0.1013
Entamoeba histolytica acyl-coA synthetase, putative 0.0118 0.0507 0.4067
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0191 0.0942
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0109 0.0144
Schistosoma mansoni tyrosine kinase 0.0321 0.1451 0.2251
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0009 0.0005 0.0008
Schistosoma mansoni acetylcholinesterase 0.0069 0.0281 0.0435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.021
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0109 0.0144
Loa Loa (eye worm) hypothetical protein 0.0181 0.0799 0.1728
Echinococcus granulosus para nitrobenzyl esterase 0.0069 0.0281 0.0436
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0012 0.0019
Echinococcus granulosus carboxylesterase 5A 0.0407 0.185 0.287
Trypanosoma brucei trypanothione reductase 0.0038 0.0137 0.035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0023 0.0021
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0035 0.0122 0.01
Loa Loa (eye worm) hypothetical protein 0.0152 0.0668 0.1443
Schistosoma mansoni histone deacetylase hda2 0.0137 0.0596 0.0923
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0007 0.0016
Echinococcus multilocularis Niemann Pick C1 protein 0.0634 0.2901 0.3827
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0035
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0027 0.0052
Plasmodium vivax glutathione reductase, putative 0.0038 0.0137 0.0132
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0062 0.0128
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0027 0.0042
Trichomonas vaginalis spcc417.12 protein, putative 0.0069 0.0281 0.1398
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0035 0.0122 0.0203
Brugia malayi Carboxylesterase family protein 0.0069 0.0281 0.0603
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0062 0.0061
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0035 0.0122 0.0203
Entamoeba histolytica hypothetical protein 0.0181 0.0802 0.644
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0136 0.0666
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0847 0.3889 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0109 0.0169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0083 0.0347 0.0664
Entamoeba histolytica protein kinase domain containing protein 0.0181 0.0802 0.644
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.01 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0013
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0133 0.0339
Loa Loa (eye worm) hypothetical protein 0.0118 0.0507 0.1095
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0099 0.0094
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0011 0.0012 0.0085
Brugia malayi hypothetical protein 0.0017 0.0039 0.0077
Leishmania major GTP-binding protein, putative 0.0022 0.0062 0.0156
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.047 0.2356
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0219 0.0469
Trichomonas vaginalis replication factor C large subunit, putative 0.0049 0.0191 0.0942
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0398 0.1804 0.9131
Echinococcus multilocularis nibrin 0.0049 0.0191 0.0252
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0133 0.0128
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0109 0.0169
Echinococcus multilocularis microtubule associated protein 2 0.1399 0.6444 0.8503
Toxoplasma gondii histone deacetylase HDAC5 0.0137 0.0596 0.0594
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0281 0.0435
Schistosoma mansoni neuropeptide receptor 0.0032 0.0109 0.0169
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0118 0.0507 0.0486
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0109 0.017
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0005 0.0005
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0035 0.0122 0.0121
Plasmodium vivax flap endonuclease 1, putative 0.0053 0.0205 0.02
Schistosoma mansoni hypothetical protein 0.0083 0.0344 0.0533
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0301 0.1356 0.2576
Loa Loa (eye worm) TK/EGFR protein kinase 0.1002 0.4608 1
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.0171 0.0438
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0122 0.0592
Schistosoma mansoni protein kinase 0.0009 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0001
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0117 0.0504 0.0985
Echinococcus granulosus neuropeptide receptor 0.0032 0.0109 0.017
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0237 0.0366
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0011 0.0031
Brugia malayi nuclear receptor NHR-67 0.0014 0.0027 0.0052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.0258
Schistosoma mansoni tyrosine kinase 0.0532 0.2428 0.3767
Leishmania major hypothetical protein, conserved 0.0011 0.0011 0.0026
Echinococcus multilocularis dna polymerase eta 0.0118 0.0509 0.0672
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0011 0.0011 0.0017
Brugia malayi ecdysone receptor 0.0014 0.0027 0.0052
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0109 0.017
Leishmania major histone deacetylase, putative 0.0325 0.1467 0.377
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0095 0.0241
Brugia malayi Dopamine receptor protein 2 0.0032 0.0109 0.0231
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0095 0.0241
Giardia lamblia Replication factor C, subunit 1 0.0049 0.0191 0.1032
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0515 0.132
Brugia malayi hypothetical protein 0.0016 0.0035 0.0069
Echinococcus granulosus allatostatin A receptor 0.0032 0.0109 0.017
Brugia malayi 6-phosphofructokinase 0.011 0.047 0.1014
Plasmodium vivax importin-beta 2, putative 0.0029 0.0098 0.0093
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1644 0.7579 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0069 0.0281 0.0435
Schistosoma mansoni hypothetical protein 0.0327 0.1479 0.2295
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0515 0.132
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0122 0.0203
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Trypanosoma brucei unspecified product 0.0064 0.0257 0.0659
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0847 0.3889 0.5131
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0434 0.1976 0.4284
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0054 0.0112
Brugia malayi Carboxylesterase family protein 0.0407 0.185 0.401
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0055
Onchocerca volvulus 0.0035 0.0122 0.1113
Schistosoma mansoni 6-phosphofructokinase 0.011 0.047 0.0728
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0159 0.0405
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0109 0.0144
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0171 0.0438
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0847 0.3889 0.844
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.0171 0.0438
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.0155
Toxoplasma gondii ck2 beta subunit 0.0037 0.0133 0.0132
Loa Loa (eye worm) histone deacetylase 0.0325 0.1467 0.3179
Loa Loa (eye worm) hypothetical protein 0.0069 0.0281 0.0603
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) carboxylesterase 0.0069 0.0281 0.0603
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.1068 0.4912 1
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0011 0.001
Plasmodium falciparum flap endonuclease 1 0.0053 0.0205 0.0204
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0001 0.0001
Chlamydia trachomatis DNA ligase 0.0049 0.0191 0.0169
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0109 0.0231
Loa Loa (eye worm) hypothetical protein 0.0081 0.0335 0.0721
Onchocerca volvulus 0.0049 0.0191 0.1759
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0012 0.0017
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0184 0.0813 0.0792
Brugia malayi N-terminal motif family protein 0.0181 0.0799 0.1728
Loa Loa (eye worm) patched family protein 0.0012 0.0018 0.0032
Echinococcus multilocularis histone deacetylase 8 0.0137 0.0596 0.0786
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0012 0.0019
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0181 0.0802 0.206
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0099 0.1119
Echinococcus granulosus somatostatin receptor 0.0032 0.0109 0.017
Entamoeba histolytica protein kinase, putative 0.0181 0.0802 0.644
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0003 0.0005
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0133 0.1216
Echinococcus granulosus neuroligin 0.0069 0.0281 0.0436
Schistosoma mansoni nuclear receptor 0.0014 0.0027 0.0041
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0109 0.0169
Brugia malayi phosphofructokinase 0.011 0.047 0.1013
Plasmodium vivax DNA repair protein REV1, putative 0.0029 0.0095 0.009
Schistosoma mansoni zinc finger protein 0.0014 0.0027 0.0041
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0054 0.0072
Toxoplasma gondii hypothetical protein 0.0012 0.0018 0.0017
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.005 0.0044
Echinococcus multilocularis protein dispatched 1 0.0447 0.2032 0.2681
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Leishmania major histone deacetylase, putative 0.0325 0.1467 0.377
Onchocerca volvulus 0.0069 0.0281 0.26
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0055
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0122 0.0258
Echinococcus multilocularis casein kinase ii subunit beta 0.0037 0.0133 0.0175
Onchocerca volvulus 0.0032 0.0109 0.0995
Echinococcus multilocularis serotonin receptor 0.0032 0.0109 0.0144
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0009 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0012 0.0017
Plasmodium falciparum thioredoxin reductase 0.0038 0.0137 0.0136
Schistosoma mansoni coup transcription factor 0.003 0.01 0.0154
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0035 0.0053
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0407 0.185 0.2869
Entamoeba histolytica recQ family DNA helicase 0.001 0.0009 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0178 0.0789 0.1224
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0349 0.0541
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.005 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.021
Brugia malayi hypothetical protein 0.0014 0.0027 0.0052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0099 0.0421 0.108
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.01 0.0155
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0237 0.0312
Giardia lamblia Flap structure-specific endonuclease 0.0053 0.0205 0.1113
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0049 0.0191 0.0942
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0109 0.017
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0016 0.0035 0.0046
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0027 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.01 0.021
Trichomonas vaginalis histone deacetylase, putative 0.0277 0.1245 0.6294
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0515 0.132
Loa Loa (eye worm) hypothetical protein 0.0069 0.0281 0.0603
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0081 0.0076
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0109 0.0144
Schistosoma mansoni myosin xvIII 0.0032 0.0109 0.0169
Brugia malayi hypothetical protein 0.0126 0.0545 0.1177
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0007 0.0016
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0109 0.017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0072 0.034
Schistosoma mansoni hypothetical protein 0.0032 0.0109 0.0169
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0035 0.0087
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0313 0.0674
Brugia malayi Dopamine receptor protein 1 0.0032 0.0109 0.0231
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0109 0.017
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0136 0.0212
Trypanosoma brucei histone deacetylase 1 0.0277 0.1245 0.32
Entamoeba histolytica hypothetical protein 0.0043 0.0162 0.1288
Toxoplasma gondii histone deacetylase HDAC4 0.0137 0.0596 0.0594
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.0515 0.132
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0122 0.01
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0012 0.0018
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0136 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0219 0.056
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Leishmania major DNA polymerase eta, putative 0.0118 0.0509 0.1307
Loa Loa (eye worm) oxidoreductase 0.0035 0.0122 0.0258
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0027 0.0042
Schistosoma mansoni biogenic amine receptor 0.0032 0.0109 0.0169
Brugia malayi AMP-binding enzyme family protein 0.0118 0.0507 0.1095
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0639 0.0843
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0122 0.01
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0171 0.0266
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0117 0.0504 0.0798
Echinococcus multilocularis bloom syndrome protein 0.002 0.0054 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0035 0.0054
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0007 0.0006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.01 0.0154
Brugia malayi Histone deacetylase 1 0.0277 0.1245 0.2698
Echinococcus multilocularis somatostatin receptor 0.0032 0.0109 0.0144
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0178 0.0789 0.1707
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0109 0.0169
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0027 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0515 0.132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Schistosoma mansoni nephrin 0.0016 0.0035 0.0053
Onchocerca volvulus 0.0012 0.0018 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0118 0.0507 0.0486
Schistosoma mansoni flap endonuclease-1 0.0048 0.0182 0.0282
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1362 0.35
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0035 0.0122 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0109 0.0169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0062 0.0156
Plasmodium falciparum histone deacetylase 2 0.0325 0.1467 0.1466
Brugia malayi Patched protein homolog 1 0.0012 0.0018 0.0032
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0095 0.0241
Loa Loa (eye worm) hypothetical protein 0.0263 0.118 0.2556
Plasmodium falciparum glutathione reductase 0.0013 0.0023 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.01 0.021
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0362 0.0694
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0277 0.1245 0.6294
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0055
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0109 0.0231
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.047 0.062
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0406 0.0594
Plasmodium vivax protein kinase Crk2 0.0045 0.0171 0.0166
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.021
Echinococcus multilocularis acetylcholinesterase 0.0407 0.185 0.244
Echinococcus granulosus nibrin 0.0049 0.0191 0.0296
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0452 0.2058 0.4462
Trypanosoma brucei unspecified product 0.0064 0.0257 0.0659
Leishmania major histone deacetylase, putative 0.0277 0.1245 0.32
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0109 0.017
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.005 0.0524
Schistosoma mansoni neuropeptide receptor 0.0032 0.0109 0.0169
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0133 0.0132
Echinococcus multilocularis histone deacetylase 6 0.0325 0.1467 0.1936
Brugia malayi CXXC zinc finger family protein 0.0029 0.0097 0.0205
Echinococcus granulosus g protein coupled receptor 0.0032 0.0109 0.017
Brugia malayi G protein-coupled receptor 0.0032 0.0109 0.0231
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.01 0.021
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0011 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0109 0.0144
Schistosoma mansoni amine GPCR 0.0032 0.0109 0.0169
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Echinococcus granulosus histone deacetylase 6 0.0325 0.1467 0.2276
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0005 0.0005
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0109 0.0169
Echinococcus multilocularis muscleblind protein 0.0452 0.2058 0.2715
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0099 0.0098
Loa Loa (eye worm) histone deacetylase 11 0.0137 0.0596 0.1287
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0109 0.0144
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0109 0.0144
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Schistosoma mansoni glutaminase 0.0276 0.1239 0.1922
Brugia malayi Melatonin receptor type 1A 0.0032 0.0109 0.0231
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0069 0.0281 0.037
Echinococcus granulosus replication factor c subunit 1 0.0049 0.0191 0.0296
Echinococcus multilocularis GPCR, family 2 0.0081 0.0335 0.0442
Echinococcus granulosus fmrfamide receptor 0.0032 0.0109 0.017
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0012 0.0019
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0035 0.0122 0.097
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0015 0.002
Brugia malayi nuclear hormone receptor 0.0014 0.0027 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.01 0.0155
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0122 0.0592
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0118 0.0507 0.0804
Toxoplasma gondii patched family protein 0.0012 0.0018 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.021
Mycobacterium ulcerans glutaminase 0.0276 0.1239 0.1219
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0062 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.01 0.021
Echinococcus granulosus snurportin 1 0.0314 0.1415 0.2196
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0011 0.0031
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0054 0.0084
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Onchocerca volvulus 0.0032 0.0109 0.0995
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0011 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.02 0.0887 0.1919
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0011 0.0031
Plasmodium vivax SET domain protein, putative 0.0031 0.0104 0.0099
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.0258
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0515 0.132
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0122 0.01
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0009 0.0005 0.001
Brugia malayi Furin-like cysteine rich region family protein 0.1002 0.4608 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0027 0.0041
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0023 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0083 0.0347 0.0664
Echinococcus granulosus flap endonuclease GEN 1 0.0011 0.0011 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0104 0.0161
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.005 0.0055
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.003 0.01 0.0158
Echinococcus multilocularis carboxylesterase 5A 0.0407 0.185 0.244
Plasmodium vivax JmjC domain containing protein 0.0016 0.0035 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.01 0.0132
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0009 0.002
Entamoeba histolytica recQ family helicase, putative 0.002 0.0054 0.0427
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0313 0.0674
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0118 0.0507 0.0991
Echinococcus granulosus epidermal growth factor receptor 0.0539 0.2461 0.3819
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0159 0.0405
Leishmania major DNA polymerase kappa, putative 0.0029 0.0095 0.0241
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0136 0.1087
Trypanosoma cruzi FHA domain containing protein, putative 0.0049 0.0191 0.0488
Brugia malayi AMP-binding enzyme family protein 0.0118 0.0507 0.1095
Plasmodium falciparum thioredoxin reductase 0.0013 0.0023 0.0021
Schistosoma mansoni adenoreceptor 0.0032 0.0109 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0486
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0055
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0109 0.0169
Brugia malayi jmjC domain containing protein 0.0016 0.0035 0.007
Onchocerca volvulus 0.0032 0.0109 0.0995
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0005 0.0005
Echinococcus granulosus neuroglian 0.0016 0.0035 0.0054
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0109 0.0144
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0023 0.0055
Brugia malayi jmjC domain containing protein 0.0016 0.0035 0.007
Schistosoma mansoni hypothetical protein 0.0327 0.1479 0.2295
Plasmodium falciparum replication factor C subunit 1, putative 0.0049 0.0191 0.019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0109 0.017
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0035 0.0069
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0035 0.007
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0009 0.0005 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.1142 0.2473
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.047 0.2356
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0109 0.0169
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0109 0.0144
Loa Loa (eye worm) acetylcholinesterase 1 0.0407 0.185 0.401
Loa Loa (eye worm) phosphofructokinase 0.011 0.047 0.1013
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0012 0.0015
Trichomonas vaginalis glutaminase, putative 0.0276 0.1239 0.6261
Schistosoma mansoni cpg binding protein 0.0031 0.0105 0.0162
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0027 0.0223
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0191 0.0488
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0122 0.031
Leishmania major pantothenate kinase subunit, putative 0.0009 0.0002 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.01 0.0154
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0133 0.1216
Loa Loa (eye worm) patched family protein 0.0012 0.0018 0.0032
Loa Loa (eye worm) patched family protein 0.0012 0.0018 0.0032
Schistosoma mansoni protein kinase 0.0009 0.0001 0.0001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0122 0.0258
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Echinococcus multilocularis 0.031 0.1398 0.1844
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.047 0.1205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0362 0.0694
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Trypanosoma cruzi histone deacetylase, putative 0.0325 0.1467 0.377
Brugia malayi histone deacetylase 3 (HD3) 0.0277 0.1245 0.2698
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0049 0.0191 0.2277
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0049 0.0191 0.0942
Mycobacterium ulcerans hypothetical protein 0.0159 0.0699 0.0678
Entamoeba histolytica DNA-repair protein, putative 0.0011 0.0011 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0515 0.132
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0109 0.017
Toxoplasma gondii exonuclease III APE 0.0019 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0069 0.0281 0.0603
Echinococcus multilocularis epidermal growth factor receptor 0.1002 0.4608 0.608
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0023 0.0055
Echinococcus granulosus tar DNA binding protein 0.0076 0.0313 0.0486
Echinococcus multilocularis histone deacetylase 6 0.0325 0.1467 0.1936
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0476
Brugia malayi Protein kinase domain containing protein 0.0321 0.1451 0.3144
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0098 0.0129
Schistosoma mansoni hypothetical protein 0.0314 0.1415 0.2196
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0171 0.0844
Loa Loa (eye worm) hypothetical protein 0.0088 0.0369 0.0795
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0109 0.0169
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.024 0.0239
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0263 0.118 0.183
Echinococcus granulosus phd:f box containing protein 0.0016 0.0035 0.0054
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0109 0.017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0109 0.0169
Loa Loa (eye worm) patched family protein 0.0012 0.0018 0.0032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.0155
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0003 0.0004
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.0887 0.1376
Onchocerca volvulus 0.0032 0.0109 0.0995
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0027 0.0035
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0137 0.0132
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0109 0.0169
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.0171 0.0438
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0012 0.0017
Leishmania major ATP-dependent phosphofructokinase 0.011 0.047 0.1205
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0054 0.0137
Schistosoma mansoni hypothetical protein 0.0043 0.0162 0.025
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0108 0.0276
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0104 0.0162
Plasmodium vivax acyl-CoA synthetase, putative 0.0088 0.0369 0.0364
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0335 0.052
Brugia malayi conserved hypotetical protein 0.0014 0.0027 0.0052
Schistosoma mansoni nuclear hormone receptor 0.003 0.01 0.0154
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Giardia lamblia DINP protein human, muc B family 0.0099 0.0421 0.2312
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Schistosoma mansoni vesicular amine transporter 0.0023 0.0066 0.0102
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.0799 0.7449
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0162 0.0251
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0109 0.017
Echinococcus granulosus serotonin receptor 0.0032 0.0109 0.017
Brugia malayi steroid hormone receptor 0.003 0.01 0.021
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0847 0.3889 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0112 0.0237
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0035 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0109 0.017
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0118 0.0507 0.1301
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0362 0.0694
Brugia malayi Myosin head containing protein 0.0012 0.0018 0.0032
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0012 0.0019
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0027 0.0042
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0023 0.0096
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0109 0.0144
Plasmodium falciparum exonuclease I, putative 0.0011 0.0011 0.001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0023 0.0055
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0109 0.0231
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0171 0.0438
Toxoplasma gondii chorismate synthase, putative 0.2166 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0335 0.0721
Loa Loa (eye worm) hypothetical protein 0.0407 0.185 0.401
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0023 0.0067 0.014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0018
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.0118 0.0507 0.0486
Trypanosoma cruzi histone deacetylase, putative 0.0325 0.1467 0.377
Schistosoma mansoni chromosome transmission fidelity factor 0.0049 0.0191 0.0295
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0476
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0035 0.0034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0335 0.0442
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0035 0.0046
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0035 0.0087
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0639 0.1381
Entamoeba histolytica Flap nuclease, putative 0.0053 0.0205 0.1642
Entamoeba histolytica phosphofructokinase, putative 0.011 0.047 0.3765
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0027 0.0035
Entamoeba histolytica Ran family GTPase 0.0022 0.0062 0.0489
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0335 0.052
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0019
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0164 0.0721 0.0952
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0552 0.2518 0.3907
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Onchocerca volvulus 0.0012 0.0018 0.0139
Schistosoma mansoni hypothetical protein 0.0417 0.1893 0.2937
Brugia malayi Importin beta-1 subunit 0.0029 0.0098 0.0206
Schistosoma mansoni DNA helicase recq1 0.002 0.0054 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0178 0.0789 0.1224
Trypanosoma cruzi histone deacetylase, putative 0.0137 0.0596 0.1529
Echinococcus granulosus defective proboscis extension response 0.0016 0.0035 0.0054
Entamoeba histolytica protein kinase, putative 0.0181 0.0802 0.644
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Echinococcus granulosus dna polymerase kappa 0.0119 0.0515 0.0798
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.0937 0.2028
Schistosoma mansoni alkaline phosphatase 0.0164 0.0721 0.1119
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.01 0.0132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.01 0.0154
Schistosoma mansoni histone deacetylase 4 5 0.0325 0.1467 0.2276
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0055
Schistosoma mansoni ran 0.0022 0.0062 0.0095
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0012 0.0015
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0362 0.0694
Brugia malayi protein C24B5.3 0.0012 0.0018 0.0032
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0112 0.0237
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0109 0.0231
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0096 0.0149
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0122 0.0258
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0486
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0012 0.0015
Loa Loa (eye worm) RNA binding protein 0.0076 0.0313 0.0674
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Onchocerca volvulus 0.0035 0.0122 0.1113
Echinococcus granulosus FTZ F1 alpha 0.003 0.01 0.0155
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0035 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0109 0.0144
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0037 0.0133 0.0132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0104 0.0137
Echinococcus granulosus importin subunit beta 1 0.0029 0.0098 0.0152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.0132
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0012 0.0018
Trypanosoma cruzi histone deacetylase 1, putative 0.0277 0.1245 0.32
Echinococcus granulosus alkaline phosphatase 0.0164 0.0721 0.112
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0398 0.1804 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0035 0.0054
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.0484 0.1241
Brugia malayi neuropeptide F receptor 0.0032 0.0109 0.0231
Echinococcus granulosus acetylcholinesterase 0.0407 0.185 0.287
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0109 0.0231
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.0109 0.0995
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0109 0.0144
Echinococcus multilocularis tumor protein p63 0.0672 0.3076 0.4059
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.005 0.0048
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0133 0.0132
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.021
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0321 0.1451 0.1914
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0108 0.0276
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.005 0.0247
Schistosoma mansoni BC026374 protein (S09 family) 0.0069 0.0281 0.0435
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0083 0.0347 0.0664
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0184 0.0813 0.0792
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0053 0.0205 0.0525
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0012 0.0015
Brugia malayi sulfakinin receptor protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) hypothetical protein 0.0049 0.0191 0.0408
Echinococcus granulosus tumor protein p63 0.0672 0.3076 0.4774
Onchocerca volvulus 0.0032 0.0109 0.0995
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.1415 0.3067
Echinococcus multilocularis Immunoglobulin 0.0016 0.0035 0.0046
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0009 0.0005 0.0004
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0106 0.0452 0.0701
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.047 0.2356
Loa Loa (eye worm) TK/INSR protein kinase 0.0321 0.1451 0.3144
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0012
Mycobacterium tuberculosis Probable reductase 0.0086 0.0362 0.0694
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0277 0.1245 0.6294
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0624 0.1603
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0406 0.0785
Onchocerca volvulus 0.0032 0.0109 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0136 0.0666
Schistosoma mansoni DNA ligase IV 0.0049 0.0191 0.0295
Plasmodium falciparum importin beta, putative 0.0029 0.0098 0.0097
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0099 0.0421 0.0815
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.01 0.0155
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0109 0.017
Treponema pallidum NADH oxidase 0.0013 0.0023 0.0169
Brugia malayi hypothetical protein 0.0016 0.0035 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0171 0.0265
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0109 0.0144
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1362 0.35
Loa Loa (eye worm) hypothetical protein 0.0088 0.0369 0.0795
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0244 0.0378
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0099 0.0077
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Schistosoma mansoni hypothetical protein 0.0085 0.0357 0.0552
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0015 0.0024
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0035 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Echinococcus granulosus g protein coupled receptor 0.0032 0.0109 0.017
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0009 0.0005 0.0032
Schistosoma mansoni histone deacetylase hda2 0.0331 0.1496 0.2321
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0109 0.0169
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0011 0.0026
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Schistosoma mansoni rotamase 0.0032 0.0112 0.0173
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0109 0.017
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0109 0.0144
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.0887 0.7117
Leishmania major DNA polymerase eta, putative 0.0054 0.0214 0.0547
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0112
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.021
Entamoeba histolytica deoxycytidyl transferase, putative 0.0092 0.039 0.3128
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0118 0.0507 0.0486
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Brugia malayi Dopamine receptor 0.0032 0.0109 0.0231
Loa Loa (eye worm) steroid hormone receptor 0.003 0.01 0.021
Echinococcus granulosus cpg binding protein 0.0031 0.0105 0.0163
Onchocerca volvulus 0.0014 0.0027 0.0223
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0109 0.0169
Toxoplasma gondii ATPase, AAA family protein 0.0049 0.0191 0.019
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0003 0.0004
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0349 0.046
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.062 0.0962
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0109 0.0144
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0109 0.017
Schistosoma mansoni ap endonuclease 0.0019 0.005 0.0076
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0016 0.0035 0.0053
Echinococcus multilocularis flap endonuclease GEN 1 0.0011 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0237 0.0367
Schistosoma mansoni tyrosine kinase 0.0539 0.2461 0.3819
Brugia malayi Patched related family protein 12 0.0012 0.0018 0.0032
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.1893 0.2498
Brugia malayi DKFZp564C0469 protein 0.0049 0.0191 0.0408
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0035 0.0122 0.031
Echinococcus granulosus histone deacetylase 7 0.0325 0.1467 0.2276
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0122 0.0258
Brugia malayi Fibronectin type III domain containing protein 0.0016 0.0035 0.0069
Plasmodium vivax patched family protein, putative 0.0012 0.0018 0.0013
Brugia malayi hypothetical protein 0.0012 0.0018 0.0032
Loa Loa (eye worm) casein kinase II 0.0011 0.0012 0.0019
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0164 0.0721 0.0952
Onchocerca volvulus 0.0118 0.0507 0.4719
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0539 0.2461 0.3819
Onchocerca volvulus 0.0035 0.0122 0.1113
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0847 0.3889 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0109 0.0144
Schistosoma mansoni hypothetical protein 0.0032 0.0109 0.0169
Loa Loa (eye worm) hypothetical protein 0.0126 0.0545 0.1177
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0301 0.1356 0.1336
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0122 0.031
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0109 0.0144
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0023 0.0021
Echinococcus granulosus sterol regulatory element binding protein 0.0434 0.1976 0.3066
Trypanosoma cruzi DNA polymerase eta, putative 0.0118 0.0509 0.1307
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0027 0.0035
Entamoeba histolytica phosphofructokinase, putative 0.011 0.047 0.3765
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0097 0.0205
Brugia malayi ORL1-like opioid receptor 0.0032 0.0109 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0095 0.0241
Plasmodium vivax histone deacetylase 1, putative 0.0277 0.1245 0.1241
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Entamoeba histolytica recQ family helicase, putative 0.001 0.0007 0.0048
Trypanosoma brucei chrX additional, unordered contigs 0.0029 0.0095 0.0241
Schistosoma mansoni hypothetical protein 0.0081 0.0335 0.0519
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0118 0.0507 0.0486
Leishmania major 4-coumarate:coa ligase-like protein 0.0118 0.0507 0.1301
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0171 0.0226
Onchocerca volvulus 0.0012 0.0018 0.0139
Entamoeba histolytica hypothetical protein 0.0043 0.0162 0.1288
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0184 0.0813 1
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0109 0.0144
Loa Loa (eye worm) glutaminase 2 0.0276 0.1239 0.2684
Brugia malayi AMP-binding enzyme family protein 0.0118 0.0507 0.1095
Brugia malayi putative neuropeptide receptor 0.0032 0.0109 0.0231
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0027 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0104 0.0161
Trichomonas vaginalis set domain proteins, putative 0.0239 0.1071 0.541
Echinococcus multilocularis para nitrobenzyl esterase 0.0069 0.0281 0.037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0054 0.0072
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0035 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0178 0.0789 0.1041
Echinococcus multilocularis neuroglian 0.0016 0.0035 0.0046
Schistosoma mansoni hypothetical protein 0.0081 0.0335 0.0519
Echinococcus granulosus bloom syndrome protein 0.002 0.0054 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0122 0.01
Schistosoma mansoni tyrosine kinase 0.0532 0.2428 0.3767
Onchocerca volvulus 0.0239 0.1071 1
Echinococcus granulosus expressed protein 0.0032 0.0112 0.0174
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.005 0.0225
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0109 0.0144
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0109 0.017
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0095 0.0241
Brugia malayi Carboxylesterase family protein 0.0069 0.0281 0.0603
Echinococcus granulosus histone deacetylase 8 0.0137 0.0596 0.0924
Echinococcus granulosus 6 phosphofructokinase 0.011 0.047 0.0729
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0053 0.0205 0.0204
Onchocerca volvulus 0.0098 0.0418 0.3882
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0171 0.0226
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0281 0.0528
Loa Loa (eye worm) hypothetical protein 0.0049 0.0191 0.0408
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0098 0.0249
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0109 0.0144
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0109 0.017
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0072 0.0183
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0012 0.0015
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0109 0.0231
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0122 0.0203
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.014 0.0216
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Onchocerca volvulus 0.0032 0.0109 0.0995
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0486
Echinococcus granulosus BC026374 protein S09 family 0.0069 0.0281 0.0436
Loa Loa (eye worm) hypothetical protein 0.018 0.0796 0.1722
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.1142 0.2473
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0109 0.0144
Giardia lamblia Exonuclease 1 0.0011 0.0011 0.0034
Brugia malayi nuclear receptor RXR 0.0014 0.0027 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Schistosoma mansoni importin beta-1 0.0029 0.0098 0.0151
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0109 0.017
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0109 0.0169
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0035 0.0122 0.01
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0011 0.0026
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0003 0.0005
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.047 0.5728
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Echinococcus multilocularis serotonin receptor 0.0032 0.0109 0.0144
Schistosoma mansoni opsin-like receptor 0.0032 0.0109 0.0169
Plasmodium falciparum histone deacetylase 1 0.0277 0.1245 0.1244
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0136 0.0348
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0072 0.034
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0049 0.0191 0.0408
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0011 0.0031
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0109 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0515 0.132
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0011 0.0026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.01 0.0905
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0161 0.016
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0109 0.0144
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0108 0.0861
Brugia malayi XPG I-region family protein 0.0011 0.0011 0.0018
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0009 0.0005 0.0007
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0178 0.0789 0.1224
Brugia malayi jmjC domain containing protein 0.0016 0.0035 0.007
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0003 0.0005
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0244 0.0379
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0043 0.0056
Brugia malayi hypothetical protein 0.0012 0.0018 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0118 0.0507 0.0991
Loa Loa (eye worm) histone methyltransferase 0.001 0.0009 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0178 0.0789 0.1707
Echinococcus multilocularis exonuclease 1 0.0011 0.0011 0.0015
Schistosoma mansoni ran 0.0022 0.0062 0.0095
Schistosoma mansoni patched 1 0.0434 0.1976 0.3065
Schistosoma mansoni hypothetical protein 0.0032 0.0109 0.0169
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0349 0.0751
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.0154
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0171 0.0266
Loa Loa (eye worm) acetyltransferase 0.0146 0.0639 0.1381
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0009 0.0005 0.0004
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0035 0.0053
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0049 0.0191 0.0169
Plasmodium falciparum chorismate synthase 0.2166 1 1
Brugia malayi hypothetical protein 0.0069 0.0281 0.0603
Brugia malayi Pre-SET motif family protein 0.021 0.0937 0.2028
Onchocerca volvulus 0.0032 0.0109 0.0995
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0005 0.0005
Brugia malayi larval opioid receptor 0.0032 0.0109 0.0231
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0095 0.0241
Onchocerca volvulus Protein patched homolog 0.0012 0.0018 0.0139
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0313 0.0414
Schistosoma mansoni hypothetical protein 0.0083 0.0344 0.0533
Loa Loa (eye worm) hypothetical protein 0.0249 0.1114 0.2412
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0164 0.0721 0.112
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0081 0.0205
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0115 0.0495 0.0767
Echinococcus multilocularis neuroligin 0.0069 0.0281 0.037
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0109 0.017
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0023 0.0017
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0027 0.0052
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0011 0.001
Schistosoma mansoni nuclear receptor 0.0014 0.0027 0.0041
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.0515 0.132
Echinococcus multilocularis geminin 0.0327 0.1479 0.1952
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0035 0.0122 0.0203
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0136 0.0212
Schistosoma mansoni hypothetical protein 0.0174 0.0769 0.1192
Echinococcus granulosus twitchin 0.0017 0.0041 0.0064
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0062 0.0057
Brugia malayi Thioredoxin reductase 0.0038 0.0137 0.0291
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0023 0.003
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0109 0.0169
Mycobacterium ulcerans acetyl-CoA synthetase 0.0035 0.0122 0.01
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0054 0.0112
Onchocerca volvulus 0.0069 0.0281 0.26
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0035 0.007
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0009 0.0005 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.01 0.021
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0006 0.0007
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0315 0.1424 0.3085
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0191 0.0942
Loa Loa (eye worm) hypothetical protein 0.0049 0.0191 0.0408
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0035 0.0122 0.01
Schistosoma mansoni cpg binding protein 0.0029 0.0097 0.015
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0099 0.0521
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0159 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0515 0.132
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0847 0.3889 0.6035
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0016 0.0035 0.0054
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0009 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0255 0.1142 0.2473
Schistosoma mansoni amine GPCR 0.0032 0.0109 0.0169
Plasmodium falciparum acyl-CoA synthetase 0.0088 0.0369 0.0368
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0009 0.0005 0.001
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0016 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0043 0.0066
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0011 0.0011 0.0018
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0098 0.0097
Leishmania major hypothetical protein, conserved 0.0026 0.0081 0.0205
Brugia malayi hypothetical protein 0.0014 0.0027 0.0052
Echinococcus multilocularis expressed protein 0.0032 0.0112 0.0148
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0171 0.0438
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0027 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0122 0.0258
Echinococcus granulosus activin receptor type 0.0009 0.0001 0.0002
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0035 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0288 0.0738
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0122 0.031
Brugia malayi cell division control protein 2 homolog 0.0045 0.0171 0.0366
Trypanosoma brucei exonuclease, putative 0.0011 0.0011 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0027 0.0042
Toxoplasma gondii histone deacetylase HDAC1 0.0325 0.1467 0.1466
Schistosoma mansoni dishevelled 0.0009 0.0003 0.0004
Giardia lamblia Casein kinase II beta chain 0.0011 0.0012 0.0036
Brugia malayi Protein kinase domain containing protein 0.0181 0.0802 0.1736
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0191 0.0488
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0161 0.016
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0109 0.0169
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0092 0.039 0.0841
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0012 0.0017
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0035 0.007
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0037 0.0133 0.0339
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0117 0.0504 0.0985
Schistosoma mansoni neuropeptide receptor 0.0032 0.0109 0.0169
Plasmodium vivax histone deacetylase 2, putative 0.0325 0.1467 0.1463
Onchocerca volvulus 0.0069 0.0281 0.26
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0054 0.0112
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.01 0.0132
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Toxoplasma gondii patched family protein 0.0012 0.0018 0.0017
Echinococcus multilocularis flap endonuclease 1 0.0053 0.0205 0.0271
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0012 0.0015
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0081 0.0205
Echinococcus multilocularis sex peptide receptor 0.0032 0.0109 0.0144
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0109 0.0144
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0136 0.0348
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0054 0.0053
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0035 0.0034
Chlamydia trachomatis dehyroquinate synthase 0.0117 0.0504 0.0483
Brugia malayi nuclear receptor NHR-88 0.0014 0.0027 0.0052
Brugia malayi histone deacetylase 1 (HD1) 0.0277 0.1245 0.2698
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.01 0.021
Echinococcus multilocularis activin receptor type 0.0009 0.0001 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0519 0.1122
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0035 0.0053
Schistosoma mansoni 3-dehydroquinate synthase 0.0117 0.0504 0.0782
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0054 0.0249
Echinococcus multilocularis acetylcholinesterase 0.0407 0.185 0.244
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0035 0.0122 0.01
Loa Loa (eye worm) hypothetical protein 0.0847 0.3889 0.844
Mycobacterium tuberculosis Carboxylesterase LipT 0.0069 0.0281 0.0528
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0023 0.0188
Trichomonas vaginalis exonuclease%2C+putative 0.0011 0.0011 0.0031
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0109 0.0169
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Brugia malayi jmjC domain containing protein 0.0059 0.0237 0.0507
Loa Loa (eye worm) glutaminase 0.0276 0.1239 0.2684
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0081 0.0205
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0171 0.0844
Brugia malayi Pax transcription activation domain interacting protein 0.0049 0.0191 0.0408
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.0515 0.132
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.01 0.021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0191 0.0408
Schistosoma mansoni 6-phosphofructokinase 0.011 0.047 0.0728
Loa Loa (eye worm) hypothetical protein 0.0088 0.0369 0.0795
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0136 0.018
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0011 0.0012 0.0085
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0003 0.0004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0161 0.025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0335 0.0442
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.007
Schistosoma mansoni hypothetical protein 0.0081 0.0335 0.0519
Toxoplasma gondii histone deacetylase HDAC3 0.0277 0.1245 0.1244
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0421 0.108
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0049 0.0191 0.0488
Echinococcus granulosus expressed conserved protein 0.0187 0.0831 0.1289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0109 0.0144
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0012 0.0017
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0069 0.0281 0.0436
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0109 0.0144
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.0109 0.0231
Brugia malayi glutaminase DH11.1 0.0276 0.1239 0.2684
Loa Loa (eye worm) histone deacetylase 7A 0.0325 0.1467 0.3179
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0035 0.0054
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0053 0.0205 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.01 0.021
Echinococcus granulosus orexin receptor type 2 0.0032 0.0109 0.017
Brugia malayi Carboxylesterase family protein 0.0069 0.0281 0.0603
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.01 0.021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0281 0.0528
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0055
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0054 0.0053
Brugia malayi Carboxylesterase family protein 0.0069 0.0281 0.0603
Brugia malayi Patched related family protein 4 0.0012 0.0018 0.0032
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0035 0.0053
Echinococcus multilocularis BC026374 protein (S09 family) 0.0069 0.0281 0.037
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.005 0.0101
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.014 0.0184
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Entamoeba histolytica phosphofructokinase, putative 0.011 0.047 0.3765
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0005 0.0005
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0054 0.0249
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0847 0.3889 0.6035
Echinococcus granulosus epidermal growth factor receptor 0.1002 0.4608 0.715
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0099 0.0786
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0109 0.017
Brugia malayi AKH receptor 0.0032 0.0109 0.0231
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0009 0.0001 0.0002
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0171 0.0366
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0133 0.1058
Plasmodium vivax replication factor C subunit 1, putative 0.0049 0.0191 0.0186
Giardia lamblia Histone deacetylase 0.0277 0.1245 0.6893
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0023 0.0017
Schistosoma mansoni tyrosine kinase 0.0539 0.2461 0.3819
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.021
Trichomonas vaginalis histone deacetylase, putative 0.0277 0.1245 0.6294
Mycobacterium ulcerans carboxylesterase, LipT 0.0069 0.0281 0.0259
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.047 0.1205
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0035 0.0053
Echinococcus multilocularis sodium channel protein 0.0106 0.0452 0.0596
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0109 0.017
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0133 0.0339
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0109 0.0144
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0109 0.017
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0137 0.0291
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0088 0.0369 0.0709
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0003 0.0004
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0263 0.118 0.1831
Brugia malayi G-protein coupled receptor 0.0032 0.0109 0.0231
Brugia malayi nuclear receptor NHR-88 0.003 0.01 0.021
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0109 0.0231
Brugia malayi follicle stimulating hormone receptor 0.0032 0.0109 0.0231
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0035 0.0122 0.0258
Entamoeba histolytica hypothetical protein 0.0043 0.0162 0.1288
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0035 0.0122 0.0121
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0122 0.0258
Onchocerca volvulus 0.003 0.01 0.0905
Echinococcus granulosus microtubule associated protein 2 0.1399 0.6444 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0162 0.0213
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0171 0.0266
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.01 0.0154
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0035 0.0069
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0109 0.0231
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.005 0.0125
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0035 0.0122 0.0258
Brugia malayi hypothetical protein 0.0049 0.0191 0.0408
Echinococcus multilocularis insulin receptor 0.0321 0.1451 0.1914
Trichomonas vaginalis histone deacetylase, putative 0.0277 0.1245 0.6294
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0109 0.017
Echinococcus granulosus tyrosine protein kinase Lyn 0.0009 0.0001 0.0002
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0214 0.0547
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0161 0.079
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Onchocerca volvulus 0.0035 0.0122 0.1113
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0023 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0171 0.0265
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0566 0.2586 0.4013
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0624 0.1603
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0109 0.0144
Brugia malayi ImpB/MucB/SamB family protein 0.0092 0.039 0.0841
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0092 0.039 0.0606
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0027 0.0052
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0023 0.0088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0109 0.0169
Toxoplasma gondii thioredoxin reductase 0.0038 0.0137 0.0136
Echinococcus granulosus acetylcholinesterase 0.0407 0.185 0.287
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0847 0.3889 1
Schistosoma mansoni hypothetical protein 0.0083 0.0349 0.054
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0184 0.0813 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0244 0.0524
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0012 0.0018
Brugia malayi polk-prov protein 0.0055 0.0219 0.0469
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0012 0.0017
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0349 0.0751
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Echinococcus multilocularis FTZ F1 alpha 0.003 0.01 0.0132
Entamoeba histolytica hypothetical protein 0.0049 0.0191 0.1524
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0349 0.054
Echinococcus multilocularis muscleblind protein 1 0.0452 0.2058 0.2715
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0301 0.1356 0.1336
Treponema pallidum DNA ligase (lig) 0.0049 0.0191 0.2262
Onchocerca volvulus 0.0031 0.0104 0.0947
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0109 0.017
Mycobacterium ulcerans DNA polymerase IV 0.0119 0.0515 0.0493
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0109 0.0169
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.005 0.0027
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0049 0.0191 0.0488
Echinococcus granulosus muscleblind protein 0.0452 0.2058 0.3193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0486
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0109 0.017
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0054 0.0112
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.01 0.0905
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0122 0.01
Trypanosoma brucei histone deacetylase, putative 0.0325 0.1467 0.377
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0136 0.0666
Brugia malayi glutathione reductase 0.0038 0.0137 0.0291
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0055
Schistosoma mansoni protein kinase 0.0009 0.0001 0.0001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.021
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0054 0.0084
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.0132
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0109 0.0231
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0035 0.0126 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.0515 0.132
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0171 0.0844
Brugia malayi casein kinase II, putaitve 0.0011 0.0012 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0109 0.0169
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0159 0.0405
Schistosoma mansoni histone deacetylase 4 5 0.0325 0.1467 0.2276
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.021
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0639 0.0991
Echinococcus granulosus GPCR family 2 0.0081 0.0335 0.052
Schistosoma mansoni histone deacetylase 0.0277 0.1245 0.1932
Schistosoma mansoni gliotactin 0.0069 0.0281 0.0435
Trypanosoma cruzi histone deacetylase 1, putative 0.0277 0.1245 0.32
Loa Loa (eye worm) hypothetical protein 0.0088 0.0369 0.0795
Trypanosoma brucei DNA polymerase eta, putative 0.0118 0.0509 0.1307
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0003 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Schistosoma mansoni hypothetical protein 0.0083 0.0344 0.0533
Echinococcus multilocularis snurportin 1 0.0314 0.1415 0.1868
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0133 0.1058
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0349 0.0541
Brugia malayi Flap endonuclease-1 0.0053 0.0205 0.044
Onchocerca volvulus Histone deacetylase 10 homolog 0.0137 0.0596 0.5547
Loa Loa (eye worm) hypothetical protein 0.0069 0.0281 0.0603
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0255 0.0394
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Brugia malayi GnHR receptor homolog 0.0032 0.0109 0.0231
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0122 0.031
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0109 0.0169
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0362 0.0501
Trypanosoma brucei histone deacetylase 3 0.0325 0.1467 0.377
Echinococcus granulosus histone deacetylase 0.0325 0.1467 0.2276
Schistosoma mansoni opsin-like receptor 0.0032 0.0109 0.0169
Brugia malayi Histone deacetylase family protein 0.0325 0.1467 0.3179
Onchocerca volvulus 0.0032 0.0109 0.0995
Onchocerca volvulus 0.0032 0.0109 0.0995
Loa Loa (eye worm) hypothetical protein 0.0049 0.0191 0.0408
Trypanosoma brucei DNA repair protein RAD2, putative 0.0011 0.0011 0.0026
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0181 0.0802 0.206
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0035 0.0046
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0027 0.0042
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0027 0.0052
Echinococcus granulosus roundabout 2 0.0016 0.0035 0.0054
Schistosoma mansoni cell adhesion molecule 0.0016 0.0035 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0191 0.0942
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0122 0.01
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0136 0.0348
Loa Loa (eye worm) hypothetical protein 0.0044 0.0165 0.0352
Loa Loa (eye worm) hypothetical protein 0.0088 0.0369 0.0795
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0049 0.0191 0.0942
Mycobacterium ulcerans chorismate synthase 0.2166 1 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0418 0.0901
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0011 0.0012 0.0019
Schistosoma mansoni alkaline phosphatase 0.0164 0.0721 0.1119
Loa Loa (eye worm) hypothetical protein 0.0434 0.1976 0.4284
Echinococcus multilocularis histone deacetylase 3 0.0277 0.1245 0.1643
Plasmodium vivax chorismate synthase 0.2166 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.005 0.0077
Brugia malayi hypothetical protein 0.0012 0.0018 0.0032
Echinococcus granulosus histone deacetylase 3 0.0277 0.1245 0.1932
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0288 0.0738
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0027 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0476
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.0769 0.1662
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.007
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0133 0.0128
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0109 0.0144
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0023 0.0043
Schistosoma mansoni histone deacetylase 1 2 3 0.0137 0.0596 0.0923
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0122 0.031
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0206
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0095 0.0241
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0281 0.0435
Loa Loa (eye worm) hypothetical protein 0.0137 0.0596 0.1287
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0099 0.0077
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0136 0.018
Toxoplasma gondii propionate-CoA ligase 0.0035 0.0122 0.0121
Entamoeba histolytica hypothetical protein 0.0043 0.0162 0.1288
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0109 0.0144
Mycobacterium ulcerans hypothetical protein 0.0029 0.0095 0.0072
Plasmodium vivax DNA repair protein RAD2, putative 0.0011 0.0011 0.0006
Brugia malayi nuclear hormone receptor 0.003 0.01 0.021
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0181 0.0802 0.206
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0049 0.0191 0.0942
Trichomonas vaginalis rotamase, putative 0.0032 0.0108 0.0523
Onchocerca volvulus 0.0012 0.0018 0.0139
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0035 0.0122 0.0161
Toxoplasma gondii histone deacetylase HDAC2 0.0277 0.1245 0.1244
Schistosoma mansoni histamine h1 receptor 0.0032 0.0109 0.0169
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0277 0.1245 0.6294
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.1362 0.35
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0108 0.0276
Trichomonas vaginalis histone deacetylase, putative 0.0277 0.1245 0.6294
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0053 0.0205 0.0525
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.01 0.021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0062 0.0156
Echinococcus multilocularis cpg binding protein 0.0031 0.0105 0.0139
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0035 0.0053
Onchocerca volvulus 0.0152 0.0668 0.6222
Schistosoma mansoni DNA polymerase eta 0.0118 0.0509 0.0789
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0009 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0088 0.0369 0.0348
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0109 0.017
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0007 0.0006
Onchocerca volvulus 0.0029 0.0097 0.0884
Loa Loa (eye worm) histone deacetylase 1 0.0277 0.1245 0.2698
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0099 0.0098
Brugia malayi hypothetical protein 0.0032 0.0109 0.0231
Echinococcus multilocularis roundabout 2 0.0016 0.0035 0.0046
Schistosoma mansoni biogenic amine receptor 0.0032 0.0109 0.0169
Loa Loa (eye worm) patched family protein 0.0012 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Brugia malayi protein C24B5.3 0.0012 0.0018 0.0032
Echinococcus granulosus histone deacetylase 6 0.0325 0.1467 0.2276
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0072 0.034
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0035 0.0122 0.01
Entamoeba histolytica acyl-CoA synthetase, putative 0.0118 0.0507 0.4067
Echinococcus granulosus geminin 0.0327 0.1479 0.2295
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0169
Trypanosoma cruzi histone deacetylase, putative 0.0137 0.0596 0.1529
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0023
Trichomonas vaginalis rotamase, putative 0.0032 0.0112 0.0541
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.01 0.0154
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0037 0.0133 0.0339
Schistosoma mansoni opsin-like receptor 0.0032 0.0109 0.0169
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0092 0.039 0.0515
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Brugia malayi RNA binding protein 0.0076 0.0313 0.0674
Mycobacterium tuberculosis Conserved hypothetical protein 0.0092 0.039 0.0752
Echinococcus multilocularis expressed conserved protein 0.0187 0.0831 0.1096
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0012 0.0032
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0171 0.0438
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0277 0.1245 0.2698
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0171 0.1368
Entamoeba histolytica hypothetical protein 0.0024 0.0072 0.0571
Schistosoma mansoni tyrosine kinase 0.0532 0.2428 0.3767
Onchocerca volvulus 0.0032 0.0109 0.0995
Loa Loa (eye worm) XPG I-region family protein 0.0011 0.0011 0.0018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0109 0.0144
Giardia lamblia hypothetical protein 0.0011 0.0011 0.0034
Loa Loa (eye worm) hypothetical protein 0.0174 0.0769 0.1662
Brugia malayi jmjC domain containing protein 0.0016 0.0035 0.007
Echinococcus granulosus intestinal type alkaline phosphatase 0.0164 0.0721 0.112
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0133 0.1058
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.0109 0.0995
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.047 0.1013
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0136 0.0211
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0109 0.017
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0109 0.017
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0847 0.3889 0.3876
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0109 0.0231
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.01 0.0154
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0164 0.0721 0.112
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.047 0.2356
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Schistosoma mansoni hypothetical protein 0.0083 0.0349 0.054
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0109 0.0144
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0062 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.01 0.021
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.1362 0.35
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0027 0.0052
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.0515 0.132
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0137 0.0234
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0109 0.0144
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0406 0.0785
Schistosoma mansoni biogenic amine receptor 0.0032 0.0109 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0178 0.0789 0.1224
Schistosoma mansoni microtubule-associated protein tau 0.1399 0.6444 1
Brugia malayi Serotonin receptor 0.0032 0.0109 0.0231
Onchocerca volvulus 0.0069 0.0281 0.26
Onchocerca volvulus 0.0012 0.0018 0.0139
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0349 0.054
Schistosoma mansoni histone deacetylase 0.0277 0.1245 0.1932
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0109 0.0144
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0011 0.0011 0.0017
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0011 0.0012 0.0019
Brugia malayi G-protein coupled receptor 0.0032 0.0109 0.0231
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0109 0.017
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0321 0.1451 0.2251
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0171 0.0226
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.0887 0.117
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0062 0.0315
Onchocerca volvulus Bile acid receptor homolog 0.003 0.01 0.0905
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0133 0.0648
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0122 0.01
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0027 0.0035
Echinococcus multilocularis dna polymerase kappa 0.0119 0.0515 0.0679
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0109 0.0169
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0088 0.0369 0.0348
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0109 0.017
Echinococcus multilocularis dual specificity 0.0181 0.0802 0.1059
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0122 0.031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0178 0.0789 0.1041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.01 0.0154
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.005 0.0101
Brugia malayi Pre-SET motif family protein 0.0031 0.0104 0.022
Schistosoma mansoni hypothetical protein 0.0081 0.0335 0.0519
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.01 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0109 0.0169
Echinococcus granulosus flap endonuclease 1 0.0053 0.0205 0.0319
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0009 0.002
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0049 0.0191 0.1524
Leishmania major histone deacetylase, putative 0.0277 0.1245 0.32
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0118 0.0507 0.1095
Brugia malayi Patched related family protein 10 0.0012 0.0018 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0112 0.0541
Brugia malayi RNA, U transporter 1 0.0084 0.0349 0.0751
Plasmodium vivax histone deacetylase, putative 0.0325 0.1467 0.1463
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.005 0.0125
Onchocerca volvulus 0.0014 0.0027 0.0223
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0476
Echinococcus multilocularis histone deacetylase 7 0.0325 0.1467 0.1936
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0023 0.0055
Loa Loa (eye worm) glutathione reductase 0.0038 0.0137 0.0291
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0035 0.0122 0.01
Brugia malayi ImpB/MucB/SamB family protein 0.0118 0.0509 0.11
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0126 0.0545 0.1177
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0418 0.0647
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0003 0.0004
Entamoeba histolytica histone deacetylase, putative 0.0277 0.1245 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0027 0.0041
Echinococcus multilocularis histone deacetylase 0.0325 0.1467 0.1936
Trichomonas vaginalis ran, putative 0.0022 0.0062 0.0288
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0109 0.0231
Brugia malayi Histone deacetylase family protein 0.0325 0.1467 0.3179
Trypanosoma cruzi histone deacetylase, putative 0.0325 0.1467 0.377
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0109 0.0231
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0109 0.0144
Onchocerca volvulus Protein patched homolog 0.0012 0.0018 0.0139
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0398 0.1804 0.9131
Loa Loa (eye worm) hypothetical protein 0.0083 0.0349 0.0751
Schistosoma mansoni dep domain containing protein 0.0009 0.0003 0.0004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0099 0.0098
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0109 0.0231
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0027 0.0041
Echinococcus granulosus Immunoglobulin 0.0016 0.0035 0.0054
Brugia malayi topoisomerase 0.0049 0.0191 0.0408
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0136 0.0729
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0023 0.0055
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0009 0.0004
Schistosoma mansoni tyrosine kinase 0.0321 0.1451 0.2251
Schistosoma mansoni amine GPCR 0.0032 0.0109 0.0169
Brugia malayi histone deacetylase 11 0.0137 0.0596 0.1287
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0122 0.0203
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0161 0.079
Brugia malayi hypothetical protein 0.0012 0.0018 0.0032
Leishmania major 4-coumarate:coa ligase-like protein 0.0118 0.0507 0.1301
Trypanosoma brucei unspecified product 0.0113 0.0484 0.1241
Loa Loa (eye worm) hypothetical protein 0.0049 0.0191 0.0408
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0018 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0118 0.0507 0.0804
Loa Loa (eye worm) hypothetical protein 0.0069 0.0281 0.0603
Schistosoma mansoni hypothetical protein 0.0083 0.0344 0.0533
Echinococcus multilocularis histone deacetylase 1 0.0277 0.1245 0.1643
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0032
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0069 0.0281 0.1398
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0118 0.0507 0.0486
Echinococcus multilocularis histone deacetylase 6 0.0331 0.1496 0.1974
Echinococcus granulosus hypothetical protein 0.0032 0.0109 0.017
Leishmania major DNA polymerase kappa, putative 0.0099 0.0421 0.108
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0023 0.0021
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0202 0.0516
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0012 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.01 0.021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.01 0.0154
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0109 0.017
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0029 0.0095 0.0094
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0109 0.0231
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0012 0.0018
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0136 0.0348
Schistosoma mansoni casein kinase II beta subunit 0.0037 0.0133 0.0205
Loa Loa (eye worm) flap endonuclease-1 0.0053 0.0205 0.044
Brugia malayi hypothetical protein 0.0049 0.0191 0.0408
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0219 0.056
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.01 0.0154
Brugia malayi Steroid receptor seven-up type 2 0.003 0.01 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0191 0.0942
Brugia malayi Patched family protein 0.0012 0.0018 0.0032
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0011 0.0012 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.01 0.021
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0099 0.0094
Brugia malayi nuclear receptor RXR 0.0016 0.0035 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0109 0.017
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0476
Echinococcus granulosus dual specificity 0.0181 0.0802 0.1245
Brugia malayi Serotonin receptor 0.0032 0.0109 0.0231
Echinococcus granulosus Niemann Pick C1 protein 0.0634 0.2901 0.4501
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0164 0.0721 0.0952
Echinococcus granulosus dna polymerase eta 0.0118 0.0509 0.079
Schistosoma mansoni amine GPCR 0.0032 0.0109 0.0169
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0035 0.0034
Echinococcus granulosus sex peptide receptor 0.0032 0.0109 0.017
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0035 0.0122 0.01
Echinococcus granulosus exonuclease 1 0.0011 0.0011 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0104 0.0161
Loa Loa (eye worm) hypothetical protein 0.0067 0.0271 0.0582
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0105 0.0448 0.0966
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.01 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0434 0.1976 1
Brugia malayi CHE-14 protein 0.0434 0.1976 0.4284
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0109 0.0144
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0313 0.0674
Plasmodium falciparum DNA repair protein RAD2, putative 0.0011 0.0011 0.001
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0136 0.018
Plasmodium vivax histone deacetylase, putative 0.0137 0.0596 0.0591
Brugia malayi MH2 domain containing protein 0.012 0.0519 0.1122
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.047 0.0914
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0109 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0515 0.132
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0095 0.0241
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0099 0.0476
Plasmodium falciparum glutathione reductase 0.0038 0.0137 0.0136
Loa Loa (eye worm) hypothetical protein 0.0069 0.0281 0.0603

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 0.9 uN h kg/mg Area under concentration time curve value of the compoundwas determined in rat ChEMBL. 15780630
Clp (ADMET) = 14 ml min-1 kg-1 Clearence value of the compoundwas determined in plasma of rat ChEMBL. 15780630
F (ADMET) = 44 % Bioavailability in rat ChEMBL. 15780630
IC50 (functional) = 0.83 uM In vitro inhibitory concentration against voltage-gated sodium channel Nav1.7 in voltage-ion-probe-reader (VIPR) assay ChEMBL. 15780630
IC50 (functional) = 0.83 uM In vitro inhibitory concentration against voltage-gated sodium channel Nav1.7 in voltage-ion-probe-reader (VIPR) assay ChEMBL. 15780630
Ki (functional) = 0.21 uM Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP) ChEMBL. 15780630
Ki (functional) = 0.21 uM Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP) ChEMBL. 15780630
T1/2 (ADMET) = 0.98 hr Half life period of the compoundwas determined in rat ChEMBL. 15780630

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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