Detailed information for compound 409885

Basic information

Technical information
  • TDR Targets ID: 409885
  • Name: (2R)-N-hydroxy-3-(4-hydroxyphenyl)-2-phenylpr opanamide
  • MW: 257.284 | Formula: C15H15NO3
  • H donors: 3 H acceptors: 3 LogP: 2.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)[C@@H](c1ccccc1)Cc1ccc(cc1)O
  • InChi: 1S/C15H15NO3/c17-13-8-6-11(7-9-13)10-14(15(18)16-19)12-4-2-1-3-5-12/h1-9,14,17,19H,10H2,(H,16,18)/t14-/m1/s1
  • InChiKey: RCJAPMSUBBEPFZ-CQSZACIVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-3-(4-hydroxyphenyl)-2-phenyl-propanehydroxamic acid
  • (2R)-3-(4-hydroxyphenyl)-2-phenylpropanehydroxamic acid
  • (2R)-N-hydroxy-3-(4-hydroxyphenyl)-2-phenyl-propanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0195 0.0147
Echinococcus multilocularis cpg binding protein 0.0016 0.0168 0.0117
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0026 0.0366 0.0304
Echinococcus granulosus carboxylesterase 5A 0.0041 0.0701 0.0898
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0041 0.0705 0.0747
Schistosoma mansoni hypothetical protein 0.0025 0.035 0.0403
Brugia malayi tailless protein 0.0012 0.0074 0.0063
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0252
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0232 0.0216
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0323 0.6695 0.6665
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0353 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0353 0.0388
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0074 0.0014
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0103 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0016 0.0167 0.0257
Echinococcus granulosus hexokinase type 2 0.0046 0.0793 0.1027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0078 0.1487 0.1702
Loa Loa (eye worm) carboxylesterase 0.0041 0.0701 0.0743
Brugia malayi Matrixin family protein 0.002 0.0248 0.0266
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0022 0.0288 0.025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0019 0.0232 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0353 0.0338
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0016 0.0167 0.0257
Leishmania major cytochrome p450-like protein 0.0016 0.0167 0.018
Loa Loa (eye worm) hypothetical protein 0.0025 0.0353 0.0338
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Toxoplasma gondii hexokinase 0.0046 0.0793 0.071
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0109 0.215 0.256
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.026 0.0389
Toxoplasma gondii CAAX amino terminal protease family protein 0.0021 0.0268 0.018
Loa Loa (eye worm) hexokinase type II 0.0046 0.0793 0.085
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0353 0.0408
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0323 0.6695 0.6674
Brugia malayi Carboxylesterase family protein 0.0041 0.0701 0.079
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0022 0.0288 0.0361
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Leishmania major hypothetical protein, conserved 0.0039 0.0654 0.0912
Echinococcus multilocularis heat shock protein 0.0036 0.0588 0.0585
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0353 0.0408
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0167 0.0121
Brugia malayi Pre-SET motif family protein 0.0017 0.0194 0.0203
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.009 0.0037
Chlamydia trachomatis dihydrofolate reductase 0.0094 0.1814 1
Schistosoma mansoni nuclear receptor 0.0012 0.0074 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0232 0.0197
Leishmania major hexokinase, putative 0.0046 0.0793 0.1121
Mycobacterium ulcerans hypothetical protein 0.0019 0.0232 0.0309
Loa Loa (eye worm) hypothetical protein 0.0025 0.0353 0.0338
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0195 0.0147
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.009 0.0063
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0013 0.009 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.026 0.0389
Mycobacterium tuberculosis Probable integral membrane protein 0.0021 0.0268 0.0474
Leishmania major trypanothione reductase 0.0036 0.0591 0.0817
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.026 0.0389
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.013 0.0062
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0022 0.0288 0.0226
Brugia malayi hypothetical protein 0.0011 0.0064 0.0052
Schistosoma mansoni heat shock protein 0.0036 0.0588 0.0739
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0016 0.0167 0.0257
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.013 0.0067
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0074 0.0011
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.023 0.4705 1
Mycobacterium ulcerans lipase LipD 0.0019 0.0232 0.0309
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0094 0.1814 0.3737
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0016 0.0167 0.0169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0353 0.0323
Onchocerca volvulus Matrilysin homolog 0.002 0.0248 0.0332
Loa Loa (eye worm) hexokinase 0.0046 0.0793 0.085
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0432 0.0519
Echinococcus granulosus dna polymerase kappa 0.0021 0.026 0.0277
Brugia malayi nuclear hormone receptor 0.0025 0.0353 0.0388
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0195 0.0147
Leishmania major hypothetical protein, conserved 0.0019 0.0232 0.0278
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0074 0.0012
Brugia malayi glutathione reductase 0.0036 0.0591 0.0663
Onchocerca volvulus Huntingtin homolog 0.007 0.1314 0.2255
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0016 0.0167 0.0257
Brugia malayi Hemopexin family protein 0.0028 0.0425 0.0471
Leishmania major cytochrome p450-like protein 0.0016 0.0167 0.018
Echinococcus granulosus GA binding protein alpha chain 0.0041 0.0705 0.0903
Loa Loa (eye worm) hypothetical protein 0.007 0.1314 0.1458
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0036 0.0591 0.1166
Plasmodium vivax hexokinase, putative 0.0046 0.0793 0.0734
Loa Loa (eye worm) hypothetical protein 0.0019 0.0232 0.0197
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.009 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0194 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0654 0.0854
Brugia malayi Endoplasmin precursor 0.0036 0.0588 0.066
Trypanosoma brucei heat shock protein, putative 0.0036 0.0588 0.0878
Schistosoma mansoni lamin 0.0046 0.0805 0.1045
Echinococcus multilocularis dna polymerase kappa 0.0021 0.026 0.022
Schistosoma mansoni cpg binding protein 0.0015 0.015 0.0121
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0016 0.0167 0.0169
Loa Loa (eye worm) intermediate filament protein 0.0046 0.0805 0.0865
Schistosoma mansoni transcription factor btf3 0.0019 0.022 0.0221
Entamoeba histolytica hypothetical protein 0.0056 0.1024 0.1128
Loa Loa (eye worm) acetylcholinesterase 1 0.0041 0.0701 0.0743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0353 0.0338
Echinococcus granulosus dnaJ subfamily B 0.0218 0.4465 0.6202
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0195 0.0147
Trypanosoma brucei hexokinase 0.0046 0.0793 0.1184
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0654 0.0854
Echinococcus multilocularis beta LACTamase domain containing family member 0.0019 0.0232 0.0188
Onchocerca volvulus 0.0017 0.0194 0.0235
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0016 0.0167 0.0257
Trypanosoma brucei PAB1-binding protein , putative 0.0014 0.013 0.0195
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0353 0.0323
Chlamydia trachomatis hypothetical protein 0.0021 0.0268 0.1037
Brugia malayi cytoplasmic intermediate filament protein 0.0025 0.035 0.0383
Echinococcus multilocularis dihydrofolate reductase 0.0094 0.1814 0.1953
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0654 0.0854
Brugia malayi cytochrome P450 0.0016 0.0167 0.0172
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.026 0.037
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0074 0.0011
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0353 0.0408
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.026 0.0389
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.026 0.0259
Schistosoma mansoni hypothetical protein 0.0025 0.035 0.0403
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.002 0.0248 0.026
Echinococcus multilocularis musashi 0.0046 0.0805 0.0828
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.013 0.0067
Plasmodium vivax SET domain protein, putative 0.0017 0.0194 0.0131
Mycobacterium tuberculosis Probable esterase LipL 0.0019 0.0232 0.0396
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.009 0.0026
Loa Loa (eye worm) hypothetical protein 0.0118 0.2338 0.2651
Trichomonas vaginalis glucosylceramidase, putative 0.0415 0.8642 1
Loa Loa (eye worm) DR-78 0.0012 0.0074 0.0012
Schistosoma mansoni hypothetical protein 0.0024 0.0337 0.0385
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0026 0.0366 0.0425
Echinococcus granulosus heat shock protein 0.0036 0.0588 0.0739
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0588 0.0878
Echinococcus multilocularis geminin 0.026 0.5337 0.5885
Echinococcus multilocularis tumor protein p63 0.0194 0.3935 0.4319
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0432 0.0519
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0017 0.0175 0.0274
Loa Loa (eye worm) endoplasmin 0.0036 0.0588 0.0611
Brugia malayi nuclear receptor RXR 0.0013 0.0103 0.0098
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0433 0.9026 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0654 0.0854
Schistosoma mansoni hypothetical protein 0.026 0.5337 0.7431
Schistosoma mansoni ets-related 0.0126 0.2499 0.3431
Schistosoma mansoni nuclear receptor 0.0012 0.0074 0.0014
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0024 0.034 0.0628
Schistosoma mansoni dihydrofolate reductase 0.0094 0.1814 0.2466
Brugia malayi beta-lactamase 0.0019 0.0232 0.0247
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.026 0.02
Toxoplasma gondii hypothetical protein 0.0021 0.0268 0.018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0248 0.0215
Brugia malayi beta-NAC-like protein 0.0019 0.022 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0019 0.0232 0.0167
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0353 0.0338
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0103 0.0056
Schistosoma mansoni hypothetical protein 0.0028 0.0425 0.0509
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0017 0.0175 0.0186
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0353 0.0408
Echinococcus granulosus dihydrofolate reductase 0.0094 0.1814 0.2466
Brugia malayi hexokinase 0.0046 0.0793 0.0897
Loa Loa (eye worm) hypothetical protein 0.0016 0.0154 0.0106
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0022 0.0288 0.0232
Mycobacterium tuberculosis Probable hydrolase 0.0019 0.0232 0.0396
Schistosoma mansoni heat shock protein 0.0015 0.0137 0.0103
Echinococcus granulosus lamin 0.0046 0.0805 0.1045
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0123 0.2434 0.5124
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0074 0.0014
Brugia malayi Cytochrome P450 family protein 0.0016 0.0167 0.0172
Schistosoma mansoni inositol monophosphatase 0.0018 0.0216 0.0215
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0268 0.0474
Brugia malayi Cytochrome P450 family protein 0.0016 0.0167 0.0172
Schistosoma mansoni transcription factor LCR-F1 0.0056 0.1024 0.1353
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0195 0.0317
Schistosoma mansoni hypothetical protein 0.0016 0.0167 0.0146
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0103 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0353 0.0388
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0167 0.0146
Onchocerca volvulus 0.0136 0.2713 0.4777
Brugia malayi follicle stimulating hormone receptor 0.0135 0.2697 0.3106
Loa Loa (eye worm) hypothetical protein 0.0041 0.0701 0.0743
Echinococcus granulosus heat shock protein 90 0.0029 0.0432 0.052
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0074 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.026 0.0259
Onchocerca volvulus 0.0046 0.0805 0.1338
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0195 0.0107
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0015 0.0137 0.0132
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0073 0.1366 0.1835
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0167 0.025
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0415 0.8642 1
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0353 0.0408
Entamoeba histolytica transcription factor BTF3, putative 0.0019 0.022 0.0106
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0026 0.0366 0.0402
Plasmodium vivax thioredoxin reductase, putative 0.0036 0.0591 0.0531
Loa Loa (eye worm) hypothetical protein 0.0019 0.0232 0.0197
Brugia malayi Dihydrofolate reductase 0.0094 0.1814 0.2082
Plasmodium falciparum basic transcription factor 3b, putative 0.0019 0.022 0.0158
Schistosoma mansoni hypothetical protein 0.0025 0.035 0.0403
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0046
Trichomonas vaginalis penicillin-binding protein, putative 0.0019 0.0232 0.0167
Echinococcus granulosus hexokinase 0.0046 0.0793 0.1027
Loa Loa (eye worm) heat shock protein 90 0.0036 0.0588 0.0611
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0017 0.0194 0.0105
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0195 0.0292
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0016 0.0174 0.0155
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0074 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0528 0.0655
Onchocerca volvulus 0.002 0.0248 0.0332
Mycobacterium tuberculosis Hypothetical protein 0.0109 0.2146 0.4505
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0041 0.0701 0.0898
Leishmania major hypothetical protein, conserved 0.0039 0.0654 0.0912
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0195 0.0185
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0167 0.0118
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0167 0.0118
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Onchocerca volvulus 0.0015 0.015 0.0155
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0016 0.0167 0.0257
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0109 0.2146 0.3113
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0353 0.0522
Trypanosoma brucei membrane transporter protein, putative 0.0039 0.0654 0.0977
Schistosoma mansoni endoplasmin 0.0036 0.0588 0.0739
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0016 0.0167 0.0169
Brugia malayi hypothetical protein 0.0012 0.0074 0.0063
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0022 0.0288 0.03
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0195 0.0132
Echinococcus multilocularis hexokinase 0.0046 0.0793 0.0814
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0074 0.0014
Brugia malayi nuclear hormone receptor 0.0012 0.0074 0.0063
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0588 0.0574
Echinococcus multilocularis hexokinase 0.0046 0.0793 0.0814
Trichomonas vaginalis set domain proteins, putative 0.0136 0.2713 0.3067
Brugia malayi Hexokinase family protein 0.0029 0.0432 0.0479
Brugia malayi thymidylate synthase 0.023 0.4705 0.5434
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.026 0.0259
Toxoplasma gondii NAC domain-containing protein 0.0019 0.022 0.0132
Echinococcus multilocularis lamin dm0 0.0046 0.0805 0.0828
Entamoeba histolytica CAAX amino terminal protease family 0.0021 0.0268 0.0167
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0016 0.0167 0.0257
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0353 0.0408
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.561 0.6454
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0046
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.009 0.0134
Brugia malayi Hsp90 protein 0.0015 0.0137 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0048 0.0071
Echinococcus multilocularis heat shock protein 90 0.0036 0.0588 0.0585
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0588 0.0755
Loa Loa (eye worm) hypothetical protein 0.0046 0.0805 0.0865
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0232 0.0347
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0022 0.0288 0.0312
Echinococcus granulosus survival motor neuron protein 1 0.0118 0.2338 0.3205
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0022 0.0288 0.0316
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0101 0.1978 0.2904
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0016 0.0167 0.0169
Toxoplasma gondii heat shock protein 75, putative 0.0015 0.0137 0.0048
Brugia malayi Matrixin family protein 0.002 0.0248 0.0266
Schistosoma mansoni lamin 0.0046 0.0805 0.1045
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0046
Trypanosoma brucei heat shock protein, putative 0.0036 0.0588 0.0878
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0016 0.0167 0.0257
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0432 0.0579
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0353 0.0323
Loa Loa (eye worm) matrixin family protein 0.0044 0.0765 0.0817
Echinococcus multilocularis hexokinase type 2 0.0046 0.0793 0.0814
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0103 0.0098
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0353 0.0408
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0591 0.0759
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0029 0.0432 0.0743
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0232 0.0216
Loa Loa (eye worm) hypothetical protein 0.0015 0.0132 0.008
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0195 0.0132
Loa Loa (eye worm) thymidylate synthase 0.023 0.4705 0.541
Loa Loa (eye worm) hypothetical protein 0.0025 0.0353 0.0338
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0074 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0323 0.6695 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0194 0.0146
Trypanosoma brucei heat shock protein, putative 0.0036 0.0588 0.0878
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0016 0.0167 0.0169
Trypanosoma brucei membrane transporter protein, putative 0.0039 0.0654 0.0977
Treponema pallidum hypothetical protein 0.0021 0.0268 0.2542
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0017 0.0194 0.0184
Brugia malayi hypothetical protein 0.0009 0.0022 0.0003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0046 0.0805 0.0865
Brugia malayi Inositol-1 0.0018 0.0216 0.0229
Mycobacterium leprae conserved hypothetical protein 0.0019 0.0232 0.0309
Trypanosoma cruzi membrane transporter protein, putative 0.0039 0.0654 0.0854
Trypanosoma brucei unspecified product 0.0017 0.019 0.0284
Schistosoma mansoni lipoxygenase 0.0068 0.1259 0.1684
Loa Loa (eye worm) ICD-1 protein 0.0019 0.022 0.0183
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0016 0.0167 0.0169
Brugia malayi Intermediate filament tail domain containing protein 0.0046 0.0805 0.0912
Plasmodium falciparum heat shock protein 90 0.0036 0.0588 0.0528
Brugia malayi conserved hypotetical protein 0.0012 0.0074 0.0063
Leishmania major hypothetical protein, conserved 0.0014 0.013 0.0124
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0022 0.0288 0.02
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0074 0.0014
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0022 0.0288 0.0226
Brugia malayi Latrophilin receptor protein 2 0.0025 0.035 0.0384
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.035 0.0403
Schistosoma mansoni intermediate filament proteins 0.0046 0.0805 0.1045
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0195 0.0147
Plasmodium vivax heat shock protein, putative 0.0015 0.0137 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0415 0.8642 1
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0353 0.0408
Trypanosoma brucei transcription factor BTF3, putative 0.0019 0.022 0.0329
Mycobacterium tuberculosis Conserved protein 0.0019 0.0232 0.0396
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0022 0.0288 0.0232
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0018 0.0216 0.0275
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0353 0.0408
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.035 0.0319
Giardia lamblia Grp94/Hsp90 0.0029 0.0432 0.0484
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.0588 0.0679
Echinococcus granulosus cpg binding protein 0.0016 0.0168 0.0147
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0353 0.0408
Brugia malayi latrophilin 2 splice variant baaae 0.0054 0.096 0.1092
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0016 0.0167 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0154 0.023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0074 0.0011
Mycobacterium ulcerans hydrolase 0.0024 0.034 0.0544
Plasmodium vivax ataxin-2 like protein, putative 0.0014 0.013 0.0067
Brugia malayi nuclear receptor NHR-88 0.0025 0.0353 0.0388
Loa Loa (eye worm) hypothetical protein 0.0041 0.0701 0.0743
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0078 0.1487 0.1702
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0074 0.0011
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0074 0.0012
Schistosoma mansoni cpg binding protein 0.0016 0.0168 0.0147
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.561 0.6454
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0194 0.0184
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0017 0.0194 0.0146
Echinococcus granulosus lamin dm0 0.0046 0.0805 0.1045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0019 0.0232 0.0238
Loa Loa (eye worm) hypothetical protein 0.0035 0.0577 0.0598
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0022 0.0297 0.0261
Brugia malayi Hexokinase family protein 0.0046 0.0793 0.0897
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0353 0.0338
Loa Loa (eye worm) hypothetical protein 0.0028 0.0425 0.0422
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0353 0.0388
Toxoplasma gondii LsmAD domain-containing protein 0.0014 0.013 0.0041
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0016 0.0167 0.0169
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0167 0.0118
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0353 0.0408
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0074 0.0014
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0074 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.0353 0.0338
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0016 0.0167 0.0257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0078 0.1487 0.1659
Trypanosoma cruzi heat shock protein, putative 0.0015 0.0137 0.0072
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0016 0.0167 0.0257
Schistosoma mansoni survival motor neuron protein 0.0024 0.0337 0.0385
Trypanosoma brucei heat shock protein, putative 0.0036 0.0588 0.0878
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0026 0.0366 0.0278
Loa Loa (eye worm) hypothetical protein 0.0024 0.034 0.0323
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0039 0.0654 0.0832
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0016 0.0167 0.0169
Treponema pallidum heat shock protein 90 0.0029 0.0432 0.4875
Echinococcus multilocularis inositol monophosphatase 1 0.0018 0.0216 0.0171
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0167 0.0121
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.026 0.02
Leishmania major hexokinase, putative 0.0046 0.0793 0.1121
Brugia malayi hypothetical protein 0.0013 0.0103 0.0098
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0015 0.0137 0.0082
Trypanosoma cruzi hexokinase, putative 0.0046 0.0793 0.1065
Mycobacterium leprae PROBABLE HYDROLASE 0.0024 0.034 0.0544
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.561 0.6454
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0018 0.0216 0.0254
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0018 0.0216 0.0148
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0353 0.0408
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0353 0.0388
Loa Loa (eye worm) hypothetical protein 0.0045 0.0787 0.0844
Onchocerca volvulus 0.0019 0.0232 0.0304
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0353 0.0388
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0056 0.1024 0.1353
Echinococcus multilocularis acetylcholinesterase 0.0041 0.0701 0.0711
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Brugia malayi steroid hormone receptor 0.0025 0.0353 0.0388
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0022 0.0288 0.043
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0195 0.0153
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0588 0.0878
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0022 0.0288 0.03
Loa Loa (eye worm) hypothetical protein 0.0025 0.0353 0.0338
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.035 0.0384
Mycobacterium ulcerans hypothetical protein 0.0021 0.0268 0.0387
Brugia malayi Ets-domain containing protein 0.0041 0.0705 0.0795
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0026 0.0366 0.0352
Brugia malayi heat shock protein 90 0.0036 0.0588 0.066
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0293 0.0237
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.009 0.0029
Entamoeba histolytica hexokinase 2 0.0046 0.0793 0.0834
Entamoeba histolytica CAAX amino terminal protease family 0.0021 0.0268 0.0167
Echinococcus multilocularis GA binding protein alpha chain 0.0041 0.0705 0.0715
Leishmania major basic transcription factor 3a, putative 0.0019 0.022 0.026
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0103 0.0056
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0074 0.0063
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0029 0.0432 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0353 0.0408
Schistosoma mansoni cpg binding protein 0.0016 0.0168 0.0147
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0018 0.0216 0.3702
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0021 0.0268 0.0474
Trypanosoma brucei CAAX amino terminal protease, putative 0.0101 0.1978 0.2955
Onchocerca volvulus 0.0029 0.0432 0.0664
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0432 0.0401
Toxoplasma gondii histone lysine methyltransferase SET1 0.003 0.0455 0.0368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0588 0.0583
Plasmodium vivax heat shock protein 90, putative 0.0015 0.0137 0.0074
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0353 0.0408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0353 0.0338
Echinococcus multilocularis expressed protein 0.0026 0.0366 0.0337
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0021 0.0268 0.0474
Onchocerca volvulus 0.0138 0.2752 0.4847
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0036 0.0581 0.0577
Loa Loa (eye worm) hypothetical protein 0.0019 0.0232 0.0197
Toxoplasma gondii hypothetical protein 0.0021 0.0268 0.018
Echinococcus multilocularis thioredoxin glutathione reductase 0.0036 0.0591 0.0588
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.009 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0016 0.0167 0.0257
Loa Loa (eye worm) hypothetical protein 0.0054 0.096 0.1045
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0353 0.0323
Brugia malayi Pax transcription factor protein 2 0.0138 0.2752 0.3169
Echinococcus granulosus geminin 0.026 0.5337 0.7431
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0167 0.0118
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0101 0.1978 0.2208
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.0167 0.0079
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0073 0.1366 0.1453
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.023 0.4705 0.6539
Loa Loa (eye worm) inositol-1 0.0018 0.0216 0.0178
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Brugia malayi hypothetical protein 0.0056 0.1024 0.1165
Brugia malayi Matrixin family protein 0.0048 0.0849 0.0963
Brugia malayi nuclear receptor RXR 0.0012 0.0074 0.0063
Echinococcus granulosus thymidylate synthase 0.023 0.4705 0.6539
Trypanosoma brucei membrane transporter protein, putative 0.0039 0.0654 0.0977
Echinococcus multilocularis heat shock protein 90 0.0029 0.0432 0.0411
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0074 0.0018
Plasmodium vivax glutathione reductase, putative 0.0036 0.0591 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0248 0.0215
Brugia malayi Ets-domain containing protein 0.0041 0.0705 0.0795
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0056 0.1024 0.1071
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0167 0.018
Onchocerca volvulus 0.0019 0.0232 0.0304
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0353 0.0522
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.023 0.4705 1
Onchocerca volvulus Huntingtin homolog 0.007 0.1314 0.2255
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.035 0.0319
Echinococcus multilocularis lamin 0.0046 0.0805 0.0828
Loa Loa (eye worm) dihydrofolate reductase 0.0094 0.1814 0.2041
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0016 0.0167 0.0169
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0101 0.1978 0.2698
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0323 0.6695 1
Trichomonas vaginalis glucosylceramidase, putative 0.0415 0.8642 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.026 0.0389
Echinococcus granulosus hexokinase 0.0046 0.0793 0.1027
Giardia lamblia Hypothetical protein 0.0101 0.1978 0.2428
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0018 0.0216 0.0192
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Entamoeba histolytica hypothetical protein 0.0109 0.215 0.256
Mycobacterium ulcerans thymidylate synthase 0.023 0.4705 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.009 0.0037
Brugia malayi Pre-SET motif family protein 0.012 0.2363 0.2718
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0039 0.0654 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0154 0.023
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0074 0.0063
Trypanosoma brucei heat shock protein, putative 0.0036 0.0588 0.0878
Onchocerca volvulus 0.0046 0.0793 0.1315
Onchocerca volvulus Hexokinase homolog 0.0029 0.0432 0.0664
Loa Loa (eye worm) hypothetical protein 0.0025 0.035 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.026 0.0389
Entamoeba histolytica hexokinase 1 0.0046 0.0793 0.0834
Plasmodium vivax endoplasmin, putative 0.0036 0.0588 0.0528
Brugia malayi MH2 domain containing protein 0.0064 0.1178 0.1345
Onchocerca volvulus Matrix metalloproteinase homolog 0.0044 0.0765 0.1264
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0019 0.0232 0.0247
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0588 0.0574
Onchocerca volvulus 0.0019 0.0232 0.0304
Brugia malayi hexokinase type II 0.0015 0.0132 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0415 0.8642 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.009 0.0063
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Schistosoma mansoni zinc finger protein 0.0012 0.0074 0.0014
Mycobacterium tuberculosis Conserved protein 0.0019 0.0232 0.0396
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0016 0.0167 0.0257
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0016 0.0167 0.0257
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.561 0.6454
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0432 0.052
Brugia malayi Cytochrome P450 family protein 0.0038 0.0632 0.0711
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0232 0.017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Plasmodium falciparum protease, putative 0.0021 0.0268 0.0206
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0047 0.0831 0.1082
Brugia malayi polk-prov protein 0.0016 0.0154 0.0157
Loa Loa (eye worm) matrix metalloproteinase 0.002 0.0248 0.0215
Echinococcus multilocularis carboxylesterase 5A 0.0041 0.0701 0.0711
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0137 0.0074
Schistosoma mansoni endoplasmin 0.0036 0.0588 0.0739
Trypanosoma brucei heat shock protein, putative 0.0036 0.0588 0.0878
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0018 0.0216 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.5921 0.6819
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.026 0.0259
Trypanosoma brucei heat shock protein, putative 0.0036 0.0588 0.0878
Loa Loa (eye worm) MH2 domain-containing protein 0.0064 0.1178 0.13
Loa Loa (eye worm) thioredoxin reductase 0.0036 0.0591 0.0615
Brugia malayi ecdysone receptor 0.0012 0.0074 0.0063
Onchocerca volvulus 0.0012 0.0074 0.0018
Mycobacterium ulcerans heat shock protein 90 0.0029 0.0432 0.0743
Onchocerca volvulus 0.0046 0.0793 0.1315
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0353 0.0388
Brugia malayi hypothetical protein 0.0014 0.013 0.0129
Toxoplasma gondii thioredoxin reductase 0.0036 0.0591 0.0506
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0353 0.0388
Echinococcus granulosus CAAX prenyl protease 2 0.0101 0.1978 0.2698
Mycobacterium ulcerans integral membrane protein 0.0021 0.0268 0.0387
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0016 0.0167 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0353 0.0388
Schistosoma mansoni gabp alpha 0.0041 0.0705 0.0903
Loa Loa (eye worm) hypothetical protein 0.0025 0.0353 0.0338
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0103 0.0056
Plasmodium vivax dihydroorotase, putative 0.0479 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0019 0.0232 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.022 0.0153
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0195 0.016
Echinococcus multilocularis GPCR, family 2 0.0025 0.035 0.0319
Echinococcus multilocularis dnaJ subfamily B 0.0218 0.4465 0.4911
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0353 0.0388
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0016 0.0167 0.0169
Loa Loa (eye worm) hypothetical protein 0.0025 0.0353 0.0338
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0167 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0194 0.0184
Brugia malayi nuclear receptor NHR-88 0.0012 0.0074 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0074 0.0014
Trypanosoma cruzi transcription factor btf3, putative 0.0019 0.022 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0194 0.0184
Brugia malayi hypothetical protein 0.0118 0.2338 0.2689
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0353 0.0338
Brugia malayi dihydrofolate reductase family protein 0.0094 0.1814 0.2082
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0074 0.0018
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0094 0.1814 0.3737
Loa Loa (eye worm) transcription factor SMAD2 0.0064 0.1178 0.13
Schistosoma mansoni hypothetical protein 0.0054 0.096 0.1264
Plasmodium vivax protease, putative 0.0021 0.0268 0.0206
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0195 0.0292
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0632 0.0662
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0275 0.0281
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0024 0.0337 0.0368
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.561 0.6454
Brugia malayi beta-lactamase family protein 0.0019 0.0232 0.0247
Echinococcus multilocularis thymidylate synthase 0.023 0.4705 0.5179
Toxoplasma gondii TIM10 family protein, putative 0.0026 0.0366 0.0278
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0353 0.0323
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0018 0.0216 0.0101
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0074 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0353 0.0388
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0016 0.0167 0.0257
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.009 0.0134
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0353 0.0408
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0353 0.0408
Echinococcus granulosus thioredoxin glutathione reductase 0.0036 0.0591 0.0743
Trypanosoma brucei trypanothione reductase 0.0036 0.0591 0.0882
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0015 0.0137 0.0103
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0025 0.035 0.0333
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0019 0.0232 0.0197
Loa Loa (eye worm) hexokinase 0.0014 0.0124 0.007
Loa Loa (eye worm) hypothetical protein 0.0014 0.013 0.0078
Trichomonas vaginalis D-aminoacylase, putative 0.0019 0.0232 0.0167
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0016 0.0167 0.0169
Mycobacterium tuberculosis Probable lipase LipE 0.0019 0.0232 0.0396
Mycobacterium ulcerans esterase/lipase LipP 0.0019 0.0232 0.0309
Echinococcus multilocularis transcription factor btf3 0.0019 0.022 0.0175
Echinococcus granulosus inositol monophosphatase 1 0.0018 0.0216 0.0215
Schistosoma mansoni multidrug resistance protein 0.0039 0.0654 0.0832
Mycobacterium tuberculosis Conserved protein 0.0019 0.0232 0.0396
Loa Loa (eye worm) hypothetical protein 0.0019 0.0232 0.0197
Plasmodium vivax heat shock protein 86, putative 0.0036 0.0588 0.0528
Loa Loa (eye worm) glutathione reductase 0.0036 0.0591 0.0615
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0074 0.0011
Entamoeba histolytica hypothetical protein 0.0056 0.1024 0.1128
Trypanosoma cruzi transcription factor btf3, putative 0.0019 0.022 0.0198
Brugia malayi hypothetical protein 0.007 0.1314 0.1502
Brugia malayi hypothetical protein 0.0011 0.0064 0.0052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0485 0.0491
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0195 0.016
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0026 0.0366 0.0304
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0137 0.0074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0353 0.0323
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0353 0.0408
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0074 0.0012
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0323 0.6695 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0068 0.1259 0.1333
Schistosoma mansoni heat shock protein 0.0036 0.0588 0.0739
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0252
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.009 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.022 0.0153
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.026 0.0389
Echinococcus multilocularis microtubule associated protein 2 0.0345 0.7161 0.7919
Toxoplasma gondii Hsp90 domain-containing protein 0.0015 0.0137 0.0048
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0588 0.0755
Schistosoma mansoni hypothetical protein 0.0218 0.4465 0.6202
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0074 0.0014
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.009 0.009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.035 0.0334
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0016 0.0167 0.0257
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0016 0.0167 0.0257
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0353 0.0408
Leishmania major cytochrome p450-like protein 0.0016 0.0167 0.018
Echinococcus granulosus transcription factor btf3 0.0019 0.022 0.0221
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0432 0.0484
Onchocerca volvulus Matrilysin homolog 0.0044 0.0765 0.1264
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0353 0.0388
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.0588 0.0878
Echinococcus granulosus microtubule associated protein 2 0.0345 0.7161 1
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0588 0.0755
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.0588 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.2146 0.2404
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0195 0.0222
Mycobacterium ulcerans hypothetical protein 0.0021 0.0268 0.0387
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0024 0.034 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0353 0.0388
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0016 0.0167 0.0169
Echinococcus granulosus tumor protein p63 0.0194 0.3935 0.5454
Toxoplasma gondii dihydroorotase 0.0479 1 1
Brugia malayi hypothetical protein 0.0012 0.0074 0.0063
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0195 0.0107
Onchocerca volvulus 0.0046 0.0793 0.1315
Brugia malayi CXXC zinc finger family protein 0.0015 0.015 0.0152
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0074 0.0063
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0353 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.026 0.0389
Echinococcus granulosus acetylcholinesterase 0.0041 0.0701 0.0898
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0353 0.0388
Treponema pallidum hexokinase (hxk) 0.0046 0.0793 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0654 0.0854
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.026 0.0389
Loa Loa (eye worm) hypothetical protein 0.0025 0.0353 0.0338
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0094 0.1814 0.3793
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0046
Loa Loa (eye worm) pax transcription factor protein 2 0.0138 0.2752 0.3134
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.009 0.0082
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0353 0.0408
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0588 0.0755
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.561 0.6454
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0018 0.0216 0.0323
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0167 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.026 0.0389
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0022 0.0288 0.0261
Plasmodium vivax basic transcription factor 3b, putative 0.0019 0.022 0.0158
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0016 0.0167 0.0257
Plasmodium falciparum glutathione reductase 0.0013 0.009 0.0026
Brugia malayi Thioredoxin reductase 0.0036 0.0591 0.0663
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0016 0.0167 0.0169
Plasmodium falciparum thioredoxin reductase 0.0036 0.0591 0.0531
Loa Loa (eye worm) heat shock protein 75 0.0015 0.0137 0.0085
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0074 0.0014
Brugia malayi hypothetical protein 0.0109 0.2146 0.2466
Onchocerca volvulus Glucosylceramidase homolog 0.0272 0.561 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0019 0.0232 0.0238
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0195 0.0204
Echinococcus multilocularis hexokinase 0.0046 0.0793 0.0814
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0016 0.0167 0.0257
Schistosoma mansoni hypothetical protein 0.0025 0.035 0.0403
Trichomonas vaginalis D-aminoacylase, putative 0.0019 0.0232 0.0167
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0137 0.0055
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0016 0.0167 0.0169
Schistosoma mansoni microtubule-associated protein tau 0.0345 0.7161 1
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0167 0.025
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0019 0.0232 0.0309
Trypanosoma brucei MATE efflux family protein, putative 0.0039 0.0654 0.0977
Loa Loa (eye worm) hypothetical protein 0.002 0.0248 0.0215
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.009 0.009
Brugia malayi beta-lactamase family protein 0.0019 0.0232 0.0247
Echinococcus granulosus GPCR family 2 0.0025 0.035 0.0403
Brugia malayi ecdysteroid receptor 0.0025 0.0353 0.0388
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.019 0.0284
Trichomonas vaginalis inositol monophosphatase, putative 0.0018 0.0216 0.0148
Onchocerca volvulus 0.0012 0.0074 0.0018
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0022 0.0288 0.0261
Loa Loa (eye worm) beta-lactamase 0.0019 0.0232 0.0197
Echinococcus granulosus endoplasmin 0.0029 0.0432 0.052
Loa Loa (eye worm) hypothetical protein 0.0078 0.1487 0.1659
Loa Loa (eye worm) hexokinase 0.0029 0.0432 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0353 0.0388
Brugia malayi Matrixin family protein 0.002 0.0248 0.0266
Loa Loa (eye worm) fli-1 protein 0.0126 0.2499 0.2838
Schistosoma mansoni coup transcription factor 0.0025 0.0353 0.0408
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0018 0.0216 0.0192
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.0167 0.0169
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.561 0.6454
Echinococcus granulosus hexokinase 0.0046 0.0793 0.1027
Echinococcus multilocularis survival motor neuron protein 1 0.0118 0.2338 0.2538
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0293 0.0237
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0323 0.6695 0.6674
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0068 0.1259 0.1684
Plasmodium falciparum glutathione reductase 0.0036 0.0591 0.0531
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0353 0.0323
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0016 0.0167 0.0169
Schistosoma mansoni hypothetical protein 0.026 0.5337 0.7431
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0022 0.0297 0.033
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0016 0.0167 0.0169
Brugia malayi Matrixin family protein 0.002 0.0248 0.0266
Loa Loa (eye worm) hypothetical protein 0.0015 0.0132 0.008
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0195 0.0185
Plasmodium falciparum thioredoxin reductase 0.0013 0.009 0.0026
Onchocerca volvulus 0.0024 0.0337 0.0492
Echinococcus multilocularis 0.0016 0.0167 0.0116
Brugia malayi Fli-1 protein 0.0126 0.2499 0.2875
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0353 0.0522
Schistosoma mansoni hypothetical protein 0.0056 0.1024 0.1353
Echinococcus granulosus expressed protein 0.0026 0.0366 0.0425
Schistosoma mansoni lipoxygenase 0.0047 0.0827 0.1075
Leishmania major heat shock protein, putative 0.0015 0.0137 0.0134
Plasmodium falciparum endoplasmin, putative 0.0022 0.0293 0.023
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0415 0.8642 1
Toxoplasma gondii heat shock protein HSP90 0.0036 0.0588 0.0503
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.026 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0018 0.0216 0.0148
Trichomonas vaginalis glucosylceramidase, putative 0.0415 0.8642 1
Trypanosoma cruzi hexokinase, putative 0.0046 0.0793 0.1065
Brugia malayi Doublecortin family protein 0.0011 0.0064 0.0052
Onchocerca volvulus 0.0028 0.0425 0.0652
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0019 0.0232 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0353 0.0388
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0074 0.0063
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0016 0.0167 0.0169
Onchocerca volvulus 0.0025 0.0353 0.0522
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0019 0.0232 0.0396
Trypanosoma brucei hexokinase 0.0046 0.0793 0.1184
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0019 0.0232 0.0396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0353 0.0338
Trypanosoma brucei hexokinase, putative 0.0046 0.0793 0.1184
Mycobacterium ulcerans beta-lactamase 0.0019 0.0232 0.0309
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0022 0.0288 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.022 0.0153
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.012 0.2363 0.268
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0135 0.2697 0.307
Brugia malayi intermediate filament protein 0.0046 0.0805 0.0912
Mycobacterium leprae putative cytochrome p450 0.0016 0.0167 0.0169
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.009 0.0026
Mycobacterium tuberculosis Probable lipase LipD 0.0019 0.0232 0.0396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.013 0.0062
Entamoeba histolytica hypothetical protein 0.0019 0.022 0.0106
Loa Loa (eye worm) hypothetical protein 0.0019 0.0232 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0012
Plasmodium falciparum hexokinase 0.0046 0.0793 0.0734
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0016 0.0167 0.0169
Giardia lamblia DNA repair protein RAD52 0.0385 0.7998 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0353 0.0323
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0167 0.0169
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0103 0.0098
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.0588 0.0503
Loa Loa (eye worm) hypothetical protein 0.0017 0.0194 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0353 0.0338
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0022 0.0288 0.0316
Trichomonas vaginalis glucosylceramidase, putative 0.0415 0.8642 1
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0022 0.0288 0.0192
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0101 0.1978 0.2859
Echinococcus granulosus heat shock protein 90 0.0036 0.0588 0.0739
Mycobacterium leprae Probable lipase LipE 0.0019 0.0232 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.026 0.0389
Schistosoma mansoni cytochrome P450 0.0016 0.0167 0.0146
Trichomonas vaginalis esterase, putative 0.0019 0.0232 0.0167
Brugia malayi Cytochrome P450 family protein 0.0016 0.0167 0.0172
Schistosoma mansoni hypothetical protein 0.0059 0.1077 0.1428
Onchocerca volvulus 0.0028 0.0425 0.0652
Loa Loa (eye worm) CXXC zinc finger family protein 0.0015 0.015 0.01
Echinococcus multilocularis endoplasmin 0.0029 0.0432 0.0411
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.009 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0016 0.0167 0.0257
Brugia malayi nuclear receptor NHR-67 0.0012 0.0074 0.0063
Loa Loa (eye worm) matrixin family protein 0.0048 0.0849 0.0916
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0013 0.009 0.009
Schistosoma mansoni hexokinase 0.0046 0.0793 0.1027
Brugia malayi CAAX amino terminal protease family protein 0.0101 0.1978 0.2272
Trypanosoma brucei heat shock protein 84, putative 0.0015 0.0137 0.0204
Brugia malayi isocitrate dehydrogenase 0.0017 0.0195 0.0204
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Schistosoma mansoni inositol monophosphatase 0.0018 0.0216 0.0215
Loa Loa (eye worm) hypothetical protein 0.007 0.1314 0.1458
Echinococcus granulosus intermediate filament protein 0.0046 0.0805 0.1045
Brugia malayi Hexokinase family protein 0.0014 0.0124 0.0121
Toxoplasma gondii ABC1 family protein 0.0019 0.0232 0.0144
Echinococcus granulosus acetylcholinesterase 0.0041 0.0701 0.0898
Brugia malayi Carboxylesterase family protein 0.0041 0.0701 0.079
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.0432 0.0826
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0016 0.0167 0.0257
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Onchocerca volvulus 0.023 0.4705 0.8368
Echinococcus multilocularis CAAX prenyl protease 2 0.0101 0.1978 0.2137
Brugia malayi hypothetical protein 0.0013 0.0103 0.0098
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.009 0.0026
Entamoeba histolytica hypothetical protein 0.0056 0.1024 0.1128
Schistosoma mansoni cellular tumor antigen P53 0.0028 0.0425 0.051
Echinococcus multilocularis acetylcholinesterase 0.0041 0.0701 0.0711
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0353 0.0388
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.009 0.0063
Trypanosoma brucei heat shock protein, putative 0.0036 0.0588 0.0878
Entamoeba histolytica hypothetical protein 0.0056 0.1024 0.1128
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0432 0.0401
Onchocerca volvulus 0.0046 0.0805 0.1338
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0101 0.1978 0.2698
Loa Loa (eye worm) cytochrome P450 0.0016 0.0167 0.0121
Loa Loa (eye worm) hexokinase 0.0046 0.0793 0.085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0297 0.0273
Leishmania major heat shock protein 83-1 0.0036 0.0588 0.0813
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.035 0.0403
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0385 0.7998 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0353 0.0408
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0101 0.1978 0.2859
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.009 0.0134
Entamoeba histolytica CAAX prenyl protease family 0.0101 0.1978 0.2342
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0432 0.0401
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0074 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.5921 0.6819
Loa Loa (eye worm) hypothetical protein 0.0101 0.1978 0.2232

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 290 uM Inhibition of CSK measured as poly-E4Y phosphorylation by acid precipitation assay in presence of 0.2 mM CoCl2 ChEMBL. 17149882
IC50 (functional) = 290 uM Inhibition of CSK measured as poly-E4Y phosphorylation by acid precipitation assay in presence of 0.2 mM CoCl2 ChEMBL. 17149882

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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