Detailed information for compound 416617

Basic information

Technical information
  • TDR Targets ID: 416617
  • Name: ethyl 4-[(E)-3-[5-(1-benzothiophen-2-yl)-2,4- dimethoxyphenyl]prop-2-enoyl]benzoate
  • MW: 472.552 | Formula: C28H24O5S
  • H donors: 0 H acceptors: 2 LogP: 6.53 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)C(=O)/C=C/c1cc(c(cc1OC)OC)c1cc2c(s1)cccc2
  • InChi: 1S/C28H24O5S/c1-4-33-28(30)19-11-9-18(10-12-19)23(29)14-13-20-15-22(25(32-3)17-24(20)31-2)27-16-21-7-5-6-8-26(21)34-27/h5-17H,4H2,1-3H3/b14-13+
  • InChiKey: AUGUFPPCGWPOHL-BUHFOSPRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[(E)-3-[5-(benzothiophen-2-yl)-2,4-dimethoxy-phenyl]prop-2-enoyl]benzoate
  • 4-[(E)-3-[5-(2-benzothiophenyl)-2,4-dimethoxyphenyl]-1-oxoallyl]benzoic acid ethyl ester
  • ethyl 4-[(E)-3-[5-(1-benzothiophen-2-yl)-2,4-dimethoxy-phenyl]prop-2-enoyl]benzoate
  • 4-[(E)-3-[5-(benzothiophen-2-yl)-2,4-dimethoxy-phenyl]acryloyl]benzoic acid ethyl ester
  • 4-[(E)-3-[5-(2-benzothiophenyl)-2,4-dimethoxyphenyl]-1-oxoprop-2-enyl]benzoic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0218 0.05 0.1657
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0018 0.0042
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0076 0.0214
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0017 0.025
Echinococcus multilocularis voltage dependent calcium channel 0.03 0.0707 0.0707
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0051 0.0051
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0041 0.0094
Loa Loa (eye worm) hypothetical protein 0.008 0.0153 0.0505
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.0557 0.1275
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0026 0.0223
Loa Loa (eye worm) hypothetical protein 0.0148 0.0323 0.1069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Brugia malayi AMP-binding enzyme family protein 0.1217 0.3019 1
Brugia malayi Smad1 0.0033 0.0034 0.0112
Leishmania major hypothetical protein, conserved 0.0032 0.0031 0.0113
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0156 0.0518
Plasmodium vivax SET domain protein, putative 0.0062 0.0106 0.2054
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0357 0.1184
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0076 0.0076
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0126 0.0269 0.0269
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.01 0.0857
Loa Loa (eye worm) hypothetical protein 0.0062 0.0106 0.0353
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0059 0.0098 0.032
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0128 0.2554
Schistosoma mansoni hypothetical protein 0.0159 0.0351 0.0803
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0026 0.0223
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0357 0.0817
Brugia malayi hypothetical protein 0.0033 0.0033 0.0109
Toxoplasma gondii HEAT repeat-containing protein 0.0056 0.0093 0.148
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0098 0.0098
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0502 0.1216 0.4029
Giardia lamblia DINP protein human, muc B family 0.0059 0.01 0.9955
Schistosoma mansoni DNA polymerase eta 0.0059 0.01 0.023
Brugia malayi beta-lactamase 0.0218 0.05 0.1657
Echinococcus granulosus pyruvate kinase 0.0032 0.0032 0.0074
Schistosoma mansoni pyruvate kinase 0.0032 0.0032 0.0074
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0026 0.0223
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0024 0.008
Loa Loa (eye worm) phosphofructokinase 0.0111 0.023 0.076
Schistosoma mansoni nuclear receptor 0.0029 0.0024 0.0055
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0037 0.0123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0099 0.0226
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0106 0.0218 0.3478
Loa Loa (eye worm) latrophilin receptor protein 2 0.0159 0.0351 0.1163
Brugia malayi AMP-binding enzyme family protein 0.0106 0.0218 0.0721
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0142 0.2774
Onchocerca volvulus 0.0049 0.0074 0.0459
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0196 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0054 0.108
Trichomonas vaginalis esterase, putative 0.0218 0.05 0.4268
Loa Loa (eye worm) hypothetical protein 0.0085 0.0165 0.0546
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0261 0.0864
Loa Loa (eye worm) fatty acid synthase 0.0054 0.0088 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.0689 0.1576
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0041 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0209 0.0692
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Trichomonas vaginalis antibiotic synthetase, putative 0.0106 0.0218 0.1856
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.0961 0.0961
Mycobacterium tuberculosis Conserved protein 0.0218 0.05 0.1441
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0024 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0106 0.0243
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0209 0.9596
Brugia malayi MH1 domain containing protein 0.0033 0.0034 0.0112
Schistosoma mansoni zinc finger protein 0.0032 0.0031 0.0071
Trichomonas vaginalis D-aminoacylase, putative 0.0218 0.05 0.4268
Loa Loa (eye worm) hypothetical protein 0.0059 0.01 0.0333
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0032 0.0275
Schistosoma mansoni acetyl-CoA synthetase 0.0106 0.0218 0.0498
Mycobacterium leprae conserved hypothetical protein 0.0218 0.05 0.1812
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0111 0.0232 0.0664
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0032 0.0516
Echinococcus granulosus geminin 0.1754 0.4371 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0009 0.0031
Mycobacterium ulcerans polyketide synthase Pks9 0.0036 0.0043 0.0135
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.023 0.4577
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.01 0.0285
Mycobacterium ulcerans beta-lactamase 0.0218 0.05 0.1652
Brugia malayi Cytochrome P450 family protein 0.0024 0.0012 0.0039
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0098 0.4056
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.0116 0.0384
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0018 0.0066
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.1217 0.3019 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0142 0.047
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.01 0.2008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0106 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1126 0.2789 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0106 0.0218 0.079
Leishmania major hypothetical protein, conserved 0.0102 0.0209 0.0759
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0293 0.0689 0.2283
Schistosoma mansoni hypothetical protein 0.0218 0.0501 0.1147
Mycobacterium tuberculosis Conserved protein 0.0218 0.05 0.1441
Brugia malayi AMP-binding enzyme family protein 0.0106 0.0218 0.0721
Echinococcus granulosus flap endonuclease 1 0.0026 0.0016 0.0038
Echinococcus granulosus sodium:myo inositol cotransporter 0.0268 0.0625 0.1431
Echinococcus granulosus beta LACTamase domain containing family member 0.0218 0.05 0.1144
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0098 0.0352
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0106 0.0106
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0106 0.0218 0.0218
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0106 0.0218 0.4349
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0128 0.0128
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0026 0.1027
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.004 0.0093
Onchocerca volvulus Fatty acid synthase homolog 0.0099 0.0201 0.1562
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0106 0.0106
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0044 0.0145
Echinococcus granulosus sodium:glucose cotransporter 0.0268 0.0625 0.1431
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0142 0.6449
Mycobacterium tuberculosis Probable thioesterase TesA 0.0046 0.0067 0.0187
Schistosoma mansoni inositol transporter 0.0268 0.0625 0.1431
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0128 0.0465
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0106 0.0218 0.0498
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0046
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0147 0.0335
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0132 0.0132
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.0196 0.0448
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0293 0.0689 0.1576
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0051 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0024 0.0055
Entamoeba histolytica hypothetical protein 0.0218 0.0501 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0059 0.0098 0.0351
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0024 0.0022
Echinococcus multilocularis high affinity choline transporter 1 0.0268 0.0625 0.0625
Echinococcus multilocularis long chain fatty acid transport protein 4 0.1126 0.2789 0.2789
Brugia malayi conserved hypotetical protein 0.0029 0.0024 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Brugia malayi Bromodomain containing protein 0.0158 0.0349 0.1157
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0159 0.0351 0.0351
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0106 0.0218 0.0784
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.023 0.0828
Loa Loa (eye worm) hypothetical protein 0.0086 0.0168 0.0556
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0024 0.0055
Trypanosoma brucei DNA polymerase eta, putative 0.0059 0.01 0.2008
Schistosoma mansoni hypothetical protein 0.0049 0.0074 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0218 0.0623
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.0196 0.0196
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0067 0.0067
Onchocerca volvulus 0.0062 0.0106 0.0736
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0209 0.4177
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.01 0.0333
Brugia malayi nuclear receptor RXR 0.0029 0.0024 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0024 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0066 0.0561
Leishmania major hypothetical protein, conserved 0.0218 0.05 0.1817
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0041 0.0055 0.0881
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0051 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0106 0.0243
Brugia malayi nuclear receptor NHR-67 0.0029 0.0024 0.008
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0106 0.0218 0.4338
Leishmania major pyruvate kinase 0.0032 0.0032 0.0117
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0098 0.0325
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0106 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0106 0.0353
Onchocerca volvulus 0.0218 0.05 0.4159
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0098 0.1964
Leishmania major GTP-binding protein, putative 0.0041 0.0055 0.02
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.1024 0.3392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0106 0.0353
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0218 0.05 0.1441
Brugia malayi RNA, U transporter 1 0.016 0.0354 0.1172
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0041 0.0136
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0106 0.0353
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.004 0.0051 0.0141
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0018 0.0018
Schistosoma mansoni sodium/solute symporter 0.0268 0.0625 0.1431
Loa Loa (eye worm) carboxylesterase 0.0065 0.0116 0.0384
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0059 0.0196
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1657
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0017 0.036
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0027 0.0018 0.0063
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0109
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0041 0.035
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0106 0.0243
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0031 0.0101
Schistosoma mansoni smad1 5 8 and 0.0033 0.0034 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0142 1
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0032 0.0092
Leishmania major DNA polymerase kappa, putative 0.0059 0.01 0.0365
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.01 0.036
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.01 0.0327
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0031 0.003 0.0081
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.03 0.0707 0.1616
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0218 0.0501 0.0501
Brugia malayi nuclear receptor NHR-88 0.0029 0.0024 0.008
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0059 0.0098 0.0351
Echinococcus granulosus voltage dependent calcium channel 0.0104 0.0214 0.049
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0055 0.009 0.0254
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0106 0.0218 0.078
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0106 0.0243
Onchocerca volvulus 0.0202 0.0459 0.3805
Schistosoma mansoni ran 0.0041 0.0055 0.0126
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0218 0.05 0.1441
Echinococcus multilocularis cpg binding protein 0.0034 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0307
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.023 0.0754
Schistosoma mansoni ran 0.0041 0.0055 0.0126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.0116 0.0265
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0106 0.0243
Loa Loa (eye worm) hypothetical protein 0.0032 0.0032 0.0107
Toxoplasma gondii hypothetical protein 0.0092 0.0182 0.2915
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0016 0.1634
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.03 0.0707 0.0707
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.023 0.4577
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0218 0.0623
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0106 0.1696
Trypanosoma brucei glucosidase, putative 0.0036 0.0041 0.082
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0012 0.0042
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0024 0.008
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0041 0.0055 0.2388
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0118 0.0247 0.0709
Schistosoma mansoni hypothetical protein 0.0032 0.0031 0.0071
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0106 0.0218 0.0715
Brugia malayi AMP-binding enzyme family protein 0.0106 0.0218 0.0721
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0026 0.0791
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0111 0.0232 0.0664
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0209 0.9596
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0111 0.0232 0.0767
Brugia malayi Bromodomain containing protein 0.0064 0.0113 0.0376
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0041 0.035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0106 0.0353
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0013 0.0013
Plasmodium falciparum flap endonuclease 1 0.0026 0.0016 0.0577
Leishmania major importin beta-1 subunit, putative 0.0046 0.0066 0.0239
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.0181
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0106 0.0218 0.0715
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.014 0.032
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0128 0.0459
Schistosoma mansoni hypothetical protein 0.006 0.0101 0.0231
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0045 0.0064 0.0181
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.0247 0.0813
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0026 0.0417
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.0247 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0018 0.0157
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0106 0.0243
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0147 0.0335
Loa Loa (eye worm) hypothetical protein 0.0062 0.0106 0.0353
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0016 0.006
Schistosoma mansoni alpha-glucosidase 0.0139 0.0301 0.0688
Brugia malayi Latrophilin receptor protein 2 0.0159 0.0351 0.1163
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0106 0.0243
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0118 0.0247 0.0818
Echinococcus multilocularis pyruvate kinase 0.0026 0.0015 0.0015
Mycobacterium ulcerans hypothetical protein 0.0106 0.0218 0.0715
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0073 0.0073
Brugia malayi nuclear receptor NHR-88 0.0062 0.0106 0.0353
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0051 0.0431
Brugia malayi Cytochrome P450 family protein 0.0035 0.0039 0.013
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0024 0.008
Echinococcus granulosus GTP binding nuclear protein Ran 0.0041 0.0055 0.0126
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0026 0.1027
Mycobacterium leprae Probable lipase LipE 0.0218 0.05 0.1812
Echinococcus multilocularis Smad4 0.0033 0.0034 0.0034
Schistosoma mansoni cpg binding protein 0.0034 0.0036 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.023 0.1958
Mycobacterium ulcerans thioesterase 0.0046 0.0067 0.0215
Schistosoma mansoni smad 0.0033 0.0034 0.0078
Schistosoma mansoni eyes absent homolog 0.0086 0.0168 0.0384
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.03 0.0707 0.234
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0128 0.0293
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1657
Echinococcus multilocularis voltage dependent calcium channel 0.03 0.0707 0.0707
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0106 0.0218 0.0784
Loa Loa (eye worm) hypothetical protein 0.0062 0.0106 0.0353
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0026 0.0223
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0159 0.0351 0.0803
Brugia malayi Cytochrome P450 family protein 0.0024 0.0012 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0106 0.0218 0.0721
Brugia malayi phosphofructokinase 0.0111 0.023 0.076
Loa Loa (eye worm) hypothetical protein 0.0091 0.0179 0.0593
Schistosoma mansoni smad1 5 8 and 0.0033 0.0034 0.0078
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0098 0.0225
Echinococcus granulosus peregrin 0.0064 0.0113 0.0259
Mycobacterium tuberculosis Conserved protein 0.0218 0.05 0.1441
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0111 0.0232 0.0761
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0033 0.0033
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0053 0.0086 0.0242
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0103 0.1651
Loa Loa (eye worm) hypothetical protein 0.0502 0.1216 0.4029
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0104 0.0214 0.0767
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0106 0.0218 0.3478
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0046 0.0067 0.0235
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0033 0.0076
Schistosoma mansoni zinc finger protein 0.0042 0.0058 0.0132
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0106 0.0243
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0142 0.0509
Brugia malayi hypothetical protein 0.0033 0.0033 0.0109
Plasmodium falciparum pyruvate kinase 0.0032 0.0032 0.1316
Echinococcus granulosus dna polymerase eta 0.0059 0.01 0.023
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0041 0.035
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0101 0.0231
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0026 0.0442
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0009 0.0019
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0106 0.0218 0.0623
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0098 0.0838
Schistosoma mansoni hypothetical protein 0.0159 0.0351 0.0803
Echinococcus granulosus long chain fatty acid transport protein 4 0.1126 0.2789 0.6381
Brugia malayi Muscleblind-like protein 0.0498 0.1206 0.3995
Echinococcus granulosus GPCR family 2 0.0159 0.0351 0.0803
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.004 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0357 0.1184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.0689 0.1576
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0195 0.0442 0.1012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0106 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Trichomonas vaginalis penicillin-binding protein, putative 0.0218 0.05 0.4268
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1657
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0012 0.0039
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0051 0.0116
Entamoeba histolytica Ran family GTPase 0.0041 0.0055 0.1099
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0032 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0106 0.0353
Mycobacterium ulcerans Type I modular polyketide synthase 0.0055 0.009 0.0291
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.0181
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0076 0.0214
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0059 0.0098 0.032
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0098 0.0278
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0024 0.0024
Brugia malayi MH2 domain containing protein 0.0033 0.0034 0.0112
Schistosoma mansoni gabp alpha 0.0071 0.0131 0.0299
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0106 0.0243
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0106 0.0736
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0016 0.0248
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0218 0.05 0.1441
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.03 0.0707 0.234
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0051 0.0116
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0093 0.185
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1657
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0106 0.0218 0.0721
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Echinococcus granulosus jumonji domain containing protein 0.0083 0.016 0.0365
Echinococcus granulosus cpg binding protein 0.0034 0.0036 0.0082
Toxoplasma gondii type I fatty acid synthase, putative 0.0073 0.0136 0.2166
Echinococcus granulosus dna polymerase kappa 0.0059 0.01 0.023
Echinococcus granulosus importin subunit beta 1 0.0056 0.0093 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0054 0.108
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.0247 0.0565
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0131 0.0433
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0032 0.0116
Entamoeba histolytica hypothetical protein 0.0218 0.0501 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0008 0.0025
Brugia malayi hypothetical protein 0.0029 0.0024 0.008
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0016 0.0141
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0106 0.0218 0.0721
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0032 0.0092
Schistosoma mansoni smad1 5 8 and 0.0033 0.0034 0.0078
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0024 0.0055
Loa Loa (eye worm) hypothetical protein 0.0343 0.0816 0.2703
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0101 0.0101
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.023 0.1958
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0116 0.0116
Leishmania major acetyl-CoA synthetase, putative 0.0106 0.0218 0.079
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.03 0.0707 0.1616
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0032 0.0088
Echinococcus multilocularis solute carrier family 5 0.0268 0.0625 0.0625
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0293 0.0689 0.0689
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0118 0.0247 0.0565
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0209 0.0749
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0142 1
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0032 0.0566
Onchocerca volvulus 0.0218 0.05 0.4159
Mycobacterium leprae Probable polyketide synthase Pks1 0.0059 0.0098 0.0351
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.01 0.0857
Loa Loa (eye worm) hypothetical protein 0.0268 0.0625 0.2072
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.05 0.1793
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0017 0.0581
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.01 0.0333
Loa Loa (eye worm) hypothetical protein 0.0082 0.0156 0.0518
Onchocerca volvulus 0.0029 0.0024 0.0022
Onchocerca volvulus Alhambra homolog 0.006 0.0101 0.0688
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0106 0.0243
Brugia malayi beta-lactamase family protein 0.0218 0.05 0.1657
Onchocerca volvulus 0.0029 0.0024 0.0022
Loa Loa (eye worm) fli-1 protein 0.0217 0.0497 0.1646
Onchocerca volvulus 0.0484 0.1172 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0293 0.0689 0.0689
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0026 0.2586
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0092 0.0182 0.0604
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0059 0.0098 0.0279
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0041 0.0818
Schistosoma mansoni alpha glucosidase 0.0036 0.0041 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0051 0.0431
Mycobacterium ulcerans polyketide synthase 0.0055 0.009 0.0291
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0026 0.0417
Plasmodium vivax hypothetical protein, conserved 0.0218 0.05 1
Schistosoma mansoni nuclear receptor 0.0029 0.0024 0.0055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0218 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0109
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0041 0.0055 0.1027
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0018 0.0042
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0044 0.0063 0.0221
Echinococcus multilocularis pyruvate kinase 0.0032 0.0032 0.0032
Plasmodium falciparum importin beta, putative 0.0056 0.0093 0.4142
Mycobacterium ulcerans Type I modular polyketide synthase 0.0055 0.009 0.0291
Onchocerca volvulus 0.0093 0.0186 0.1427
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0018 0.0294
Entamoeba histolytica acyl-CoA synthetase, putative 0.0111 0.0232 0.4618
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0051 0.0116
Mycobacterium ulcerans hypothetical protein 0.0218 0.05 0.1652
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.06 0.1464 0.485
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0074 0.0247
Loa Loa (eye worm) hypothetical protein 0.0062 0.0106 0.0353
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0032 0.0645
Loa Loa (eye worm) hypothetical protein 0.0106 0.0218 0.0721
Echinococcus granulosus zinc finger protein 0.0042 0.0058 0.0132
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.023 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0218 0.05 0.4268
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0044 0.0063 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Echinococcus granulosus voltage dependent calcium channel 0.03 0.0707 0.1616
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0106 0.0243
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0195 0.0442 0.0442
Mycobacterium tuberculosis Probable hydrolase 0.0218 0.05 0.1441
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0156 0.0358
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0142 0.2266
Entamoeba histolytica acyl-CoA synthetase, putative 0.0106 0.0218 0.4338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0106 0.0106
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0209 0.0749
Entamoeba histolytica hypothetical protein 0.0046 0.0066 0.1311
Mycobacterium tuberculosis Probable lipase LipD 0.0218 0.05 0.1441
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0009 0.0022
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0111 0.0232 0.0664
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0106 0.0218 0.0623
Schistosoma mansoni inositol transporter 0.0268 0.0625 0.1431
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0076 0.0174
Loa Loa (eye worm) hypothetical protein 0.006 0.0101 0.0334
Schistosoma mansoni voltage-gated cation channel 0.03 0.0707 0.1616
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0025
Trypanosoma cruzi ISWI complex protein 0.0032 0.0031 0.0112
Brugia malayi jmjC domain containing protein 0.0078 0.0147 0.0486
Loa Loa (eye worm) oxidoreductase 0.0106 0.0218 0.0721
Loa Loa (eye worm) hypothetical protein 0.0106 0.0218 0.0721
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0017 0.0053
Onchocerca volvulus 0.0218 0.05 0.4159
Toxoplasma gondii exonuclease III APE 0.0058 0.0098 0.157
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0026 0.0223
Schistosoma mansoni cpg binding protein 0.0028 0.0022 0.005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0098 0.9733
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0142 0.0464
Toxoplasma gondii propionate-CoA ligase 0.0106 0.0218 0.3478
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0156 0.0156
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0059 0.0098 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0106 0.0353
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0032 0.0116
Loa Loa (eye worm) hypothetical protein 0.0065 0.0116 0.0384
Echinococcus multilocularis muscleblind protein 1 0.0498 0.1206 0.1206
Brugia malayi MH2 domain containing protein 0.0033 0.0034 0.0112
Echinococcus granulosus sodium:glucose cotransporter 2 0.0268 0.0625 0.1431
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0218 0.0501 0.1147
Schistosoma mansoni Smad4 0.0033 0.0034 0.0078
Toxoplasma gondii ABC1 family protein 0.0218 0.05 0.7996
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0126 0.0269 0.0615
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0502 0.1216 0.4029
Schistosoma mansoni FFA transport protein 0.1126 0.2789 0.6381
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0012 0.0032
Brugia malayi 6-phosphofructokinase 0.0111 0.023 0.076
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0128 0.0424
Mycobacterium ulcerans polyketide synthase 0.0059 0.0098 0.032
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0209 0.4128
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0128 0.2561
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.01 0.2008
Loa Loa (eye worm) DR-78 0.0029 0.0024 0.008
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0041 0.0149
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.023 0.076
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0012 0.0042
Brugia malayi ecdysone receptor 0.0029 0.0024 0.008
Echinococcus granulosus acetylcholinesterase 0.0065 0.0116 0.0265
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0106 0.0218 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0106 0.0353
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0041 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.01 0.036
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0033 0.0076
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0218 0.0623
Brugia malayi hypothetical protein 0.0241 0.0557 0.1846
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0022 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0062 0.0106 0.0353
Onchocerca volvulus 0.0082 0.0156 0.1171
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0034 0.0034
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0268 0.0625 0.0625
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0024 0.008
Plasmodium vivax acetyl-CoA synthetase, putative 0.0106 0.0218 0.4301
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0218 0.0623
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0024 0.0024
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0268 0.0625 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0142 0.6027
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0232 0.0761
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0034 0.0078
Echinococcus granulosus carboxylesterase 5A 0.0065 0.0116 0.0265
Echinococcus granulosus muscleblind protein 0.0498 0.1206 0.2759
Loa Loa (eye worm) hypothetical protein 0.0241 0.0557 0.1846
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0051 0.1007
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0055 0.009 0.032
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0041 0.0055 0.0183
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0106 0.0218 0.0715
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0159 0.0351 0.0351
Leishmania major pyruvate kinase 0.0032 0.0032 0.0117
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0016 0.033
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.004 0.0093
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0009 0.0032
Echinococcus granulosus high affinity choline transporter 1 0.0268 0.0625 0.1431
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.023 0.0525
Echinococcus granulosus AMP dependent ligase 0.002 0.0002 0.0004
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0106 0.0736
Schistosoma mansoni bromodomain containing protein 0.0134 0.0288 0.0658
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.004 0.004
Schistosoma mansoni ap endonuclease 0.0058 0.0098 0.0225
Leishmania major 4-coumarate:coa ligase-like protein 0.0106 0.0218 0.079
Brugia malayi Calcitonin receptor-like protein seb-1 0.0502 0.1216 0.4029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0214 0.0709
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0106 0.0218 0.0715
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0218 0.0623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.0689 0.1576
Loa Loa (eye worm) hypothetical protein 0.0097 0.0196 0.0648
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0218 0.05 0.1652
Echinococcus granulosus pyruvate kinase 0.0032 0.0032 0.0074
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0033 0.0076
Onchocerca volvulus 0.0106 0.0218 0.1702
Onchocerca volvulus 0.0062 0.0106 0.0733
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.03 0.0707 0.1616
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.1111 0.2752 0.7951
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.023 0.0658
Loa Loa (eye worm) hypothetical protein 0.0086 0.0168 0.0556
Trypanosoma brucei unspecified product 0.0041 0.0054 0.108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Brugia malayi jmjC domain containing protein 0.0195 0.0442 0.1466
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.03 0.0707 0.0707
Brugia malayi hypothetical protein 0.0218 0.0501 0.1661
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0026 0.0442
Plasmodium falciparum phd finger protein, putative 0.006 0.0101 0.4534
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0082 0.0159 0.0453
Brugia malayi Fli-1 protein 0.0217 0.0497 0.1646
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0016 0.0055
Brugia malayi 6-phosphofructokinase 0.0111 0.023 0.076
Toxoplasma gondii type I fatty acid synthase, putative 0.0039 0.005 0.0795
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.011 0.0227 0.0752
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0055 0.009 0.032
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0157 0.0347 0.1151
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0106 0.0218 0.078
Loa Loa (eye worm) hypothetical protein 0.0062 0.0106 0.0353
Schistosoma mansoni high-affinity choline transporter 0.0268 0.0625 0.1431
Entamoeba histolytica hypothetical protein 0.0218 0.0501 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0041 0.0055 0.0183
Loa Loa (eye worm) calcium channel 0.03 0.0707 0.234
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0104 0.0214 0.428
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0016 0.0016
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0106 0.0218 0.0721
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0053 0.0053
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0012 0.0039
Leishmania major 4-coumarate:coa ligase-like protein 0.0106 0.0218 0.079
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0106 0.0353
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0116 0.0116
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0024 0.0055
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0268 0.0625 0.0625
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0142 0.0464
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0209 0.334
Plasmodium vivax hypothetical protein, conserved 0.006 0.0101 0.195
Brugia malayi Ets-domain containing protein 0.0071 0.0131 0.0433
Schistosoma mansoni hypothetical protein 0.06 0.1464 0.3349
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0034 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0106 0.0243
Echinococcus multilocularis smad 0.0033 0.0034 0.0034
Brugia malayi Flap endonuclease-1 0.0026 0.0016 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0106 0.0353
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0098 0.0838
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0106 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.023 0.1958
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.023 0.1958
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0051 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0106 0.0353
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1657
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0106 0.0353
Loa Loa (eye worm) transcription factor SMAD2 0.0484 0.1171 0.3878
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0024 0.0055
Brugia malayi MH2 domain containing protein 0.0484 0.1171 0.3878
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0041 0.0655
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0106 0.0353
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0024 0.008
Loa Loa (eye worm) acyl carrier protein 0.0025 0.0015 0.0049
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0106 0.0106
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0026 0.1312
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.01 0.0285
Echinococcus granulosus lysine specific demethylase 5A 0.0078 0.0147 0.0335
Brugia malayi beta-lactamase family protein 0.0218 0.05 0.1657
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0041 0.0055 0.0198
Echinococcus multilocularis dna polymerase kappa 0.0059 0.01 0.01
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0111 0.0232 0.0761
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0293 0.0689 0.1576
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0032 0.0107
Leishmania major DNA polymerase eta, putative 0.0059 0.01 0.0365
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0498 0.1206 0.3995
Loa Loa (eye worm) hypothetical protein 0.0106 0.0218 0.0721
Echinococcus multilocularis AMP dependent ligase 0.002 0.0002 0.0002
Brugia malayi Sodium:solute symporter family protein 0.0268 0.0625 0.2072
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0032 0.0107
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0106 0.0218 0.0784
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0105 0.0214 0.071
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0357 0.0357
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.016 0.016
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.0247 0.0247
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.023 0.0823
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0098 0.0319
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.01 0.023
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0009 0.0024
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0051 0.0167
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0106 0.0218 0.0715
Brugia malayi Importin beta-1 subunit 0.0056 0.0093 0.0307
Trichomonas vaginalis ran, putative 0.0041 0.0055 0.047
Toxoplasma gondii transporter, cation channel family protein 0.0104 0.0214 0.3422
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.03 0.0707 0.1616
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Loa Loa (eye worm) hypothetical protein 0.0159 0.0351 0.1163
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0059 0.0098 0.0279
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0111 0.0232 0.0835
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0106 0.0106
Echinococcus multilocularis importin subunit beta 1 0.0056 0.0093 0.0093
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0033 0.0109
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.0116 0.0116
Mycobacterium tuberculosis Probable lipase LipE 0.0218 0.05 0.1441
Schistosoma mansoni hypothetical protein 0.0159 0.0351 0.0803
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0034 0.0078
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0024 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0484 0.1172 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0098 0.6729
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0106 0.0106
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0106 0.0218 0.079
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0009 0.0208
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0016 0.0059
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0098 0.0325
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0196 0.0448
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0293 0.0689 0.2283
Schistosoma mansoni zinc finger protein 0.0029 0.0024 0.0055
Trypanosoma brucei unspecified product 0.0041 0.0054 0.108
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.023 0.0525
Echinococcus granulosus solute carrier family 5 0.0268 0.0625 0.1431
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0128 0.0424
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0128 0.0459
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0131 0.0299
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0026 0.0223
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.03 0.0707 0.0707
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0093 0.185
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.101
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0106 0.0243
Entamoeba histolytica hypothetical protein 0.0023 0.0009 0.0172
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.01 0.2003
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0091 0.018 0.0516
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0073 0.0168
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0106 0.0243
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.014 0.014
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0009 0.009
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0016 0.0264
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.023 0.0834
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0041 0.035
Loa Loa (eye worm) hypothetical protein 0.0062 0.0106 0.0353
Mycobacterium tuberculosis Probable esterase LipL 0.0218 0.05 0.1441
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.1111 0.2752 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0106 0.0353
Schistosoma mansoni hypothetical protein 0.0159 0.0351 0.0803
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0034 0.0078
Echinococcus granulosus snurportin 1 0.06 0.1464 0.3349
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0101 0.0334
Brugia malayi tailless protein 0.0029 0.0024 0.008
Giardia lamblia Pyruvate kinase 0.0032 0.0032 0.3196
Schistosoma mansoni hypothetical protein 0.1754 0.4371 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0076 0.0269
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0018 0.0367
Schistosoma mansoni ap endonuclease 0.0058 0.0098 0.0225
Schistosoma mansoni hypothetical protein 0.0046 0.0067 0.0152
Schistosoma mansoni survival motor neuron protein 0.0049 0.0074 0.017
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0024 0.0055
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.023 0.4589
Loa Loa (eye worm) MH2 domain-containing protein 0.0484 0.1171 0.3878
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0106 0.0243
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0106 0.0353
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0142 0.0142
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0111 0.0232 0.0761
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.023 0.4577
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0012 0.0234
Onchocerca volvulus 0.0268 0.0625 0.5249
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0268 0.0625 0.1431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0051 0.0184
Entamoeba histolytica hypothetical protein 0.0218 0.0501 1
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0024 0.0055
Echinococcus granulosus Smad4 0.0033 0.0034 0.0078
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.023 0.076
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0026 0.0223
Brugia malayi nuclear hormone receptor 0.0062 0.0106 0.0353
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0041 0.0055 0.0198
Echinococcus granulosus smad 0.0033 0.0034 0.0078
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0055 0.009 0.0291
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0109
Trypanosoma brucei ISWI complex protein 0.0032 0.0031 0.0624
Mycobacterium ulcerans acetyl-CoA synthetase 0.0106 0.0218 0.0715
Leishmania major cytochrome p450-like protein 0.0024 0.0012 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Brugia malayi steroid hormone receptor 0.0062 0.0106 0.0353
Trichomonas vaginalis antibiotic synthetase, putative 0.0106 0.0218 0.1856
Loa Loa (eye worm) Smad1 0.0033 0.0034 0.0112
Brugia malayi Pre-SET motif family protein 0.0426 0.1024 0.3392
Brugia malayi PHD-finger family protein 0.0054 0.0086 0.0284
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0106 0.0218 0.078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0106 0.0353
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0106 0.0353
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0041 0.035
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.01 0.023
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0106 0.0218 0.0715
Brugia malayi Pre-SET motif family protein 0.0062 0.0106 0.0351
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0142 0.0324
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0106 0.0218 0.4349
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Brugia malayi AMP-binding enzyme family protein 0.0157 0.0347 0.1151
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0106 0.0353
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0024 0.008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0218 0.05 0.1144
Brugia malayi MH1 domain containing protein 0.0033 0.0034 0.0112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0106 0.0243
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.01 0.0365
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0051 0.0116
Trypanosoma cruzi ISWI complex protein 0.0032 0.0031 0.0112
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0106 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0066 0.0561
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0106 0.0243
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0008 0.0152
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0142 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0128 0.0293
Echinococcus multilocularis dna polymerase eta 0.0059 0.01 0.01
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0041 0.035
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0067 0.0152
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0041 0.0055 0.1102
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0051 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0106 0.0243
Mycobacterium leprae Polyketide synthase Pks13 0.0082 0.0159 0.057
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0036 0.0041 0.0655
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0098 0.1959
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0032 0.0645
Schistosoma mansoni jumonji domain containing protein 0.0155 0.0341 0.0781
Schistosoma mansoni coup transcription factor 0.0062 0.0106 0.0243
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0218 0.05 0.1144
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0018 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0041 0.035
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0106 0.0353
Echinococcus multilocularis peregrin 0.0064 0.0113 0.0113
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0106 0.0218 0.0623
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0106 0.0218 0.0715
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0032 0.0101
Echinococcus multilocularis geminin 0.1754 0.4371 0.4371
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0024 0.0024
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0142 0.0324
Loa Loa (eye worm) hypothetical protein 0.0218 0.05 0.1657
Schistosoma mansoni flap endonuclease-1 0.0024 0.001 0.0023
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0101 0.0231
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0041 0.0136
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0024 0.0022
Trypanosoma brucei unspecified product 0.0059 0.01 0.2008
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.023 0.023
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0032 0.0092
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0034 0.0112
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.01 0.2008
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0106 0.0218 0.078
Brugia malayi Ets-domain containing protein 0.0071 0.0131 0.0433
Loa Loa (eye worm) hypothetical protein 0.0107 0.0221 0.0733
Echinococcus multilocularis GPCR, family 2 0.0159 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.0343 0.0816 0.1866
Mycobacterium ulcerans Type I modular polyketide synthase 0.0055 0.009 0.0291
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0111 0.0232 0.0664
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0013 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0106 0.0106
Brugia malayi nuclear receptor RXR 0.0033 0.0033 0.0109
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1126 0.2789 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0106 0.0218 0.4338
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0026 0.052
Loa Loa (eye worm) hypothetical protein 0.0065 0.0116 0.0384
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0022 0.0072
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0106 0.0353
Schistosoma mansoni transcription factor LCR-F1 0.0218 0.0501 0.1147
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0357 0.0357
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0118 0.0247 0.0898
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0159 0.0351 0.0803
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0101 0.1613
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0055 0.009 0.0254
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0101 0.1613
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.03 0.0707 0.1616
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0023 0.0053
Brugia malayi Bromodomain containing protein 0.008 0.0152 0.0504
Onchocerca volvulus 0.0119 0.0252 0.1998
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Schistosoma mansoni ets-related 0.0217 0.0497 0.1137
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1217 0.3019 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0041 0.035
Brugia malayi hypothetical protein 0.0066 0.0117 0.0389
Brugia malayi Carboxylesterase family protein 0.0065 0.0116 0.0384
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0106 0.0243
Brugia malayi latrophilin 2 splice variant baaae 0.0343 0.0816 0.2703
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0002 0.0038
Echinococcus multilocularis snurportin 1 0.06 0.1464 0.1464
Echinococcus multilocularis pyruvate kinase 0.0032 0.0032 0.0032
Mycobacterium ulcerans lipase LipD 0.0218 0.05 0.1652
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0106 0.0736
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0041 0.0055 0.5463
Trypanosoma brucei hypothetical protein, conserved 0.0218 0.05 1
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0024 0.008
Echinococcus multilocularis zinc finger protein 0.0042 0.0058 0.0058
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0066 0.0236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0106 0.0353
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0024 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0106 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0109
Mycobacterium ulcerans esterase/lipase LipP 0.0218 0.05 0.1652
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.01 0.023
Schistosoma mansoni hypothetical protein 0.1754 0.4371 1
Schistosoma mansoni hypothetical protein 0.0401 0.0961 0.2199
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0041 0.035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0106 0.0353
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0218 0.0715
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0167
Brugia malayi hypothetical protein 0.0102 0.0209 0.0692
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0073 0.0168
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0036 0.0043 0.0135
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0218 0.05 0.1657
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1392 0.3461 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0032 0.011
Toxoplasma gondii hypothetical protein 0.0026 0.0017 0.0265
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0066 0.0561
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.0557 0.0557
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0026 0.1312
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0024 0.0055
Schistosoma mansoni importin beta-1 0.0056 0.0093 0.0212
Leishmania major acetyl-CoA synthetase, putative 0.0106 0.0218 0.079
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.05 0.1793
Brugia malayi PHD-finger family protein 0.006 0.0101 0.0334
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0024 0.0024
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.03 0.0707 0.0707
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.023 0.0525
Plasmodium vivax importin-beta 2, putative 0.0056 0.0093 0.1782
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0044 0.0063 0.0201
Schistosoma mansoni cpg binding protein 0.0034 0.0036 0.0082
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0109
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0009 0.0138
Loa Loa (eye worm) hypothetical protein 0.0062 0.0106 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0106 0.0353
Onchocerca volvulus 0.0106 0.0218 0.1702
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0033 0.0109
Onchocerca volvulus 0.0157 0.0347 0.2831
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0036 0.0043 0.0148
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.01 0.0333
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0009 0.0138
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0051 0.5006
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0106 0.0243
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0034 0.0112
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0024 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0218 0.05 0.4268
Leishmania major pantothenate kinase subunit, putative 0.0027 0.0018 0.0064
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0055 0.009 0.0254
Schistosoma mansoni alpha-glucosidase 0.0139 0.0301 0.0688
Loa Loa (eye worm) hypothetical protein 0.0061 0.0105 0.0346
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0111 0.0232 0.0761
Chlamydia trachomatis pyruvate kinase 0.0032 0.0032 0.1775
Loa Loa (eye worm) hypothetical protein 0.0268 0.0625 0.2072
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0024 0.008
Brugia malayi Probable ClpP-like protease 0.0076 0.0142 0.047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.01 0.036
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0024 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0041 0.0147
Giardia lamblia PHD finger protein 15 0.006 0.0101 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0053 0.0122
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0016 0.0329
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0156 0.0358
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0032 0.0275
Brugia malayi Carboxylesterase family protein 0.0065 0.0116 0.0384
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0033 0.0109
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0053 0.0086 0.0242
Loa Loa (eye worm) hypothetical protein 0.0102 0.0208 0.069
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0082 0.0159 0.0453
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0098 0.1896
Echinococcus multilocularis muscleblind protein 0.0498 0.1206 0.1206
Brugia malayi hypothetical protein 0.0086 0.0168 0.0556
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0098 0.4408
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.01 0.0327
Echinococcus granulosus dnaJ subfamily B 0.0401 0.0961 0.2199
Schistosoma mansoni pyruvate kinase 0.0032 0.0032 0.0074
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0055 0.009 0.0297
Echinococcus granulosus acetylcholinesterase 0.0065 0.0116 0.0265
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0039 0.013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.008
Brugia malayi GH02984p 0.0268 0.0625 0.2072
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0268 0.0625 0.0625
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0157 0.0347 0.0999
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0106 0.0218 0.0784
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.01 0.036
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0098 0.0357
Brugia malayi AMP-binding enzyme family protein 0.0106 0.0218 0.0721
Entamoeba histolytica hypothetical protein 0.0027 0.0018 0.0367
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0041 0.0818
Loa Loa (eye worm) jmjC domain-containing protein 0.0078 0.0147 0.0486
Loa Loa (eye worm) voltage-dependent calcium channel 0.0104 0.0214 0.0709
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0159 0.0351 0.1163
Brugia malayi ecdysteroid receptor 0.0062 0.0106 0.0353
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0012 0.0039
Trypanosoma cruzi DNA polymerase eta, putative 0.0059 0.01 0.036
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0142 0.2266
Brugia malayi nuclear hormone receptor 0.0029 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0092 0.0182 0.0604
Trichomonas vaginalis D-aminoacylase, putative 0.0218 0.05 0.4268
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0026 0.0417
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0032 0.0107
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0106 0.0353
Leishmania major fatty acid transporter protein-like protein 0.1111 0.2752 1
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0131 0.0131
Brugia malayi PHD-finger family protein 0.0025 0.0014 0.0046
Mycobacterium ulcerans thioesterase TesA 0.0046 0.0067 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Loa Loa (eye worm) beta-lactamase 0.0218 0.05 0.1657
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0095
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0098 0.0352
Loa Loa (eye worm) hypothetical protein 0.0498 0.1206 0.3995
Schistosoma mansoni hypothetical protein 0.0043 0.0059 0.0136
Brugia malayi CXXC zinc finger family protein 0.0028 0.0022 0.0072
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0032 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.01 0.2008
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0058 0.0929
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0041 0.0147
Brugia malayi hypothetical protein 0.0029 0.0024 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0054 0.108
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0009 0.0172
Mycobacterium ulcerans polyketide synthase Pks13 0.0082 0.0159 0.0519
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0107 0.0245

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.1 uM Inhibition of TNFalpha-induced VCAM1 expression in HPAECs ChEMBL. 17323940

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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