Detailed information for compound 47397

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 277.403 | Formula: C20H23N
  • H donors: 0 H acceptors: 0 LogP: 4.48 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN2[C@@H](CC1)c1ccccc1[C@@H](C2)c1ccccc1
  • InChi: 1S/C20H23N/c1-3-9-16(10-4-1)19-15-21-14-8-2-5-13-20(21)18-12-7-6-11-17(18)19/h1,3-4,6-7,9-12,19-20H,2,5,8,13-15H2/t19-,20+/m1/s1
  • InChiKey: WHSGDLAYIFWZTF-UXHICEINSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0081 0.0768 0.224
Echinococcus multilocularis cyclin B3 1 0.0153 0.1613 0.1619
Onchocerca volvulus 0.0049 0.04 0.0583
Trypanosoma cruzi cyclin 6, putative 0.0207 0.2245 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0129 0.1331 0.1329
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0151 0.0221
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0198 0.0291
Plasmodium falciparum cyclin 0.0153 0.1613 0.8231
Mycobacterium ulcerans proteasome PrcA 0.0871 1 1
Trichomonas vaginalis AGC family protein kinase 0.0086 0.083 0.268
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.0468 0.1945
Schistosoma mansoni hypothetical protein 0.0032 0.0198 0.0164
Echinococcus multilocularis cyclin dependent kinase 5 0.0055 0.0468 0.0441
Plasmodium falciparum importin beta, putative 0.0033 0.0213 0.0907
Loa Loa (eye worm) blistered cuticle protein 3 0.0599 0.682 1
Schistosoma mansoni Cyclin fold protein 0.0037 0.0257 0.0224
Entamoeba histolytica hypothetical protein 0.0027 0.014 0.0395
Schistosoma mansoni Mername-AA248 (C02 family) 0.0027 0.0141 0.0104
Echinococcus granulosus cyclin b3 0.0153 0.1613 0.1619
Entamoeba histolytica cyclin, putative 0.0207 0.2245 0.6571
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.0468 0.1945
Echinococcus multilocularis protein jagged 2 0.0062 0.0545 0.0521
Echinococcus multilocularis protein kinase shaggy 0.0055 0.0473 0.0447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Echinococcus multilocularis Cyclin L1 0.0037 0.0257 0.0224
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0116 0.118 0.5125
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0406 0.1583
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0063 0.0079
Loa Loa (eye worm) hypothetical protein 0.0373 0.4183 0.6134
Echinococcus granulosus protein kinase c epsilon type 0.0315 0.3511 0.3571
Onchocerca volvulus Peroxidasin homolog 0.0599 0.682 1
Trichomonas vaginalis glutaminase, putative 0.0271 0.2988 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0468 0.1455
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0196 0.0161
Plasmodium vivax cyclin homologue, putative 0.0037 0.0257 0.1141
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0771 0.0753
Echinococcus granulosus neurogenic locus protein delta 0.0062 0.0545 0.0521
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0273 0.0791
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0116 0.118 0.5172
Leishmania major hypothetical protein, conserved 0.0082 0.0785 0.338
Schistosoma mansoni notch 0.0062 0.0545 0.0521
Echinococcus granulosus mitogen activated protein kinase 0.0116 0.118 0.1173
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0111 0.0373
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0785 0.0527
Trichomonas vaginalis cyclins, putative 0.0091 0.0889 0.2882
Echinococcus multilocularis snurportin 1 0.0353 0.3951 0.4023
Schistosoma mansoni flap endonuclease-1 0.0023 0.01 0.0062
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0116 0.118 0.5172
Brugia malayi calpain family protein 1 0.0053 0.0448 0.0657
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0169 0.1797 0.1808
Echinococcus multilocularis myotubularin protein 13 0.0077 0.0724 0.0705
Brugia malayi C1-like domain containing protein 0.0214 0.232 0.3402
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0442 0.0648
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2268 0.3326
Entamoeba histolytica diacylglycerol kinase, putative 0.0072 0.0672 0.1957
Brugia malayi Animal haem peroxidase family protein 0.0599 0.682 1
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Schistosoma mansoni atypical protein kinase C 0.0255 0.2801 0.2841
Entamoeba histolytica hypothetical protein 0.0023 0.0092 0.0256
Trichomonas vaginalis cyclins, putative 0.0037 0.0257 0.074
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0274 0.3028 0.3074
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.2176 0.2198
Schistosoma mansoni ran 0.0024 0.0111 0.0073
Echinococcus granulosus cyclins 0.0153 0.1613 0.1619
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0086 0.083 0.1217
Trichomonas vaginalis cyclin B, putative 0.0153 0.1613 0.5336
Echinococcus granulosus cyclins 0.0153 0.1613 0.1619
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0055 0.0473 0.1969
Echinococcus multilocularis microtubule associated protein 2 0.0752 0.8605 0.8811
Loa Loa (eye worm) hypothetical protein 0.0079 0.0752 0.1103
Echinococcus multilocularis fibropellin Ia 0.0062 0.0545 0.0521
Loa Loa (eye worm) hypothetical protein 0.0205 0.2221 0.3256
Schistosoma mansoni ran 0.0024 0.0111 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0198 0.0291
Entamoeba histolytica protein kinase, putative 0.0086 0.083 0.242
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0055 0.0473 0.0447
Echinococcus granulosus cyclin y 0.0037 0.0257 0.0224
Echinococcus multilocularis neurogenic locus notch protein 0.0062 0.0545 0.0521
Brugia malayi beta-lactamase 0.0082 0.0785 0.1151
Loa Loa (eye worm) hypothetical protein 0.0101 0.1002 0.1469
Echinococcus granulosus poly ADP ribose polymerase 1 0.0307 0.3413 0.347
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0479 0.0452
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Schistosoma mansoni hypothetical protein 0.0062 0.0545 0.0521
Schistosoma mansoni vav2 0.0077 0.0724 0.0705
Echinococcus granulosus calpain A 0.0059 0.0516 0.049
Echinococcus granulosus notch 0.0062 0.0545 0.0521
Entamoeba histolytica protein kinase, putative 0.0074 0.0689 0.2006
Loa Loa (eye worm) hypothetical protein 0.005 0.0406 0.0596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Schistosoma mansoni hypothetical protein 0.0353 0.3951 0.4023
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0196 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0063 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0785 0.2528
Schistosoma mansoni cpg binding protein 0.0094 0.0929 0.0915
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0638 0.2714
Loa Loa (eye worm) cyclin domain-containing protein 0.0037 0.0257 0.0378
Giardia lamblia Hypothetical protein 0.0153 0.1613 0.704
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0061 0.0097
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0182 0.1951 0.8669
Loa Loa (eye worm) hypothetical protein 0.0082 0.0785 0.1151
Entamoeba histolytica PH domain containing protein kinase, putative 0.0186 0.2003 0.5863
Echinococcus granulosus lamin dm0 0.0028 0.0151 0.0114
Schistosoma mansoni septate junction protein 0.0062 0.0545 0.0521
Echinococcus granulosus intermediate filament protein 0.0028 0.0151 0.0114
Brugia malayi RhoGAP domain containing protein 0.0072 0.0672 0.0986
Loa Loa (eye worm) hypothetical protein 0.0129 0.1331 0.1952
Trichomonas vaginalis cyclin B3, putative 0.0153 0.1613 0.5336
Echinococcus granulosus cyclin 0.0037 0.0257 0.0224
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0072 0.0672 0.0651
Plasmodium vivax SET domain protein, putative 0.0032 0.0196 0.082
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.004 0.0295 0.1158
Echinococcus granulosus calcium dependent protein kinase 0.0065 0.059 0.0566
Schistosoma mansoni cell polarity protein 0.0062 0.0545 0.0521
Trichomonas vaginalis cyclins, putative 0.0207 0.2245 0.7478
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0129 0.0255
Loa Loa (eye worm) hypothetical protein 0.0072 0.0672 0.0986
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0224 0.244 0.247
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1002 0.1469
Brugia malayi calpain 7 0.002 0.0061 0.0089
Entamoeba histolytica protein kinase, putative 0.009 0.0882 0.2573
Onchocerca volvulus 0.0082 0.0785 0.1148
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.2844 0.2885
Echinococcus granulosus cyclin t1 0.0037 0.0257 0.0224
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0061 0.0097
Entamoeba histolytica cyclin C, putative 0.0037 0.0257 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0257 0.074
Schistosoma mansoni hypothetical protein 0.0851 0.9761 1
Echinococcus granulosus poly (ADP ribose) polymerase 0.0048 0.0383 0.0354
Leishmania major protein kinase, putative 0.0074 0.0689 0.2944
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0257 0.074
Schistosoma mansoni cyclin G 0.0037 0.0257 0.0224
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0037 0.0257 0.0901
Onchocerca volvulus 0.0018 0.0039 0.0054
Echinococcus granulosus cyclins 0.0153 0.1613 0.1619
Onchocerca volvulus 0.0062 0.0545 0.0797
Loa Loa (eye worm) AGC/PKA protein kinase 0.0182 0.1951 0.2861
Echinococcus granulosus cyclin B 0.0207 0.2245 0.2268
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0039 0.01
Echinococcus granulosus cyclin k 0.0037 0.0257 0.0224
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0198 0.0291
Loa Loa (eye worm) hypothetical protein 0.0074 0.0689 0.101
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0061 0.0097
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0479 0.0452
Echinococcus granulosus cyclin dependent kinase 5 0.0055 0.0468 0.0441
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Loa Loa (eye worm) hypothetical protein 0.0049 0.04 0.0586
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Entamoeba histolytica hypothetical protein 0.0023 0.0092 0.0256
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.2176 0.2198
Loa Loa (eye worm) hypothetical protein 0.0072 0.0672 0.0986
Giardia lamblia Kinase, CMGC CDK 0.0055 0.0468 0.1676
Echinococcus multilocularis N chimaerin 0.0072 0.0672 0.0651
Trichomonas vaginalis cyclin B, putative 0.0207 0.2245 0.7478
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0224 0.244 0.247
Echinococcus granulosus cyclin dependent kinase 1 0.0055 0.0468 0.0441
Schistosoma mansoni cyclin B3 0.0274 0.3028 0.3074
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0086 0.083 0.0813
Echinococcus multilocularis protein kinase c eta type 0.0072 0.0672 0.0651
Brugia malayi Cadherin domain containing protein 0.0062 0.0545 0.08
Onchocerca volvulus 0.0599 0.682 1
Trypanosoma brucei cyclin 9 0.0037 0.0257 0.0901
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.1951 0.1967
Entamoeba histolytica diacylglycerol kinase, putative 0.0072 0.0672 0.1957
Leishmania major mitotic cyclin, putative 0.0037 0.0257 0.0989
Trypanosoma brucei cyclin 3 0.0037 0.0257 0.0901
Echinococcus granulosus Diacylglycerol kinase theta 0.0072 0.0672 0.0651
Plasmodium vivax importin-beta 2, putative 0.0033 0.0213 0.0907
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0074 0.0689 0.1848
Entamoeba histolytica hypothetical protein 0.0074 0.0687 0.2002
Echinococcus multilocularis serine:threonine protein kinase 38 0.0086 0.083 0.0813
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0273 0.0784
Echinococcus granulosus neurogenic locus notch protein 0.0062 0.0545 0.0521
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0785 0.0767
Schistosoma mansoni glutaminase 0.0271 0.2988 0.3033
Trichomonas vaginalis AGC family protein kinase 0.0086 0.083 0.268
Loa Loa (eye worm) notch protein 0.0062 0.0545 0.08
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Trichomonas vaginalis AGC family protein kinase 0.009 0.0882 0.2857
Echinococcus multilocularis Diacylglycerol kinase theta 0.0072 0.0672 0.0651
Entamoeba histolytica hypothetical protein 0.0072 0.0672 0.1957
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0213 0.0696
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0055 0.0468 0.0687
Leishmania major protein kinase A catalytic subunit 0.0182 0.1951 0.8669
Entamoeba histolytica cyclin family protein 0.0153 0.1613 0.4718
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0037 0.0257 0.0378
Loa Loa (eye worm) hypothetical protein 0.0033 0.0213 0.0313
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0473 0.1472
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0785 0.0527
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0037 0.0257 0.1141
Echinococcus multilocularis lamin 0.0028 0.0151 0.0114
Brugia malayi EGF-like domain containing protein 0.0062 0.0545 0.08
Echinococcus granulosus raf serine:threonine protein kinase 0.0072 0.0672 0.0651
Schistosoma mansoni hypothetical protein 0.0062 0.0545 0.0521
Echinococcus multilocularis slit 2 protein 0.0062 0.0545 0.0521
Loa Loa (eye worm) tnks protein 0.0023 0.0092 0.0135
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0182 0.1951 0.1967
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Trypanosoma brucei protein kinase, putative 0.0055 0.0473 0.189
Schistosoma mansoni peroxidasin 0.0599 0.682 0.6975
Schistosoma mansoni notch 0.0062 0.0545 0.0521
Schistosoma mansoni hypothetical protein 0.0032 0.0198 0.0164
Schistosoma mansoni g1/s-specific cyclin C 0.0037 0.0257 0.0224
Loa Loa (eye worm) hypothetical protein 0.0207 0.2245 0.3291
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0213 0.0696
Brugia malayi EGF-like domain containing protein 0.0062 0.0545 0.08
Echinococcus multilocularis fat cadherin tumor suppressor 0.0062 0.0545 0.0521
Leishmania major hypothetical protein, conserved 0.005 0.0406 0.1665
Schistosoma mansoni lamin 0.0028 0.0151 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0638 0.2714
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Entamoeba histolytica hypothetical protein 0.0074 0.0687 0.2002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0063 0.0079
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0473 0.1374
Brugia malayi RhoGEF domain containing protein 0.0072 0.0672 0.0986
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0785 0.2528
Schistosoma mansoni tankyrase 0.0023 0.0092 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0063 0.0079
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0129 0.1331 0.1329
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0116 0.118 0.5172
Trichomonas vaginalis AGC family protein kinase 0.009 0.0882 0.2857
Echinococcus multilocularis musashi 0.0028 0.0151 0.0114
Brugia malayi cell division control protein 2 homolog 0.0055 0.0468 0.0687
Echinococcus multilocularis G1:S specific cyclin D1 0.0037 0.0257 0.0224
Brugia malayi hypothetical protein 0.0032 0.0201 0.0294
Trichomonas vaginalis ran, putative 0.0024 0.0111 0.0242
Brugia malayi hypothetical protein 0.0037 0.0257 0.0378
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.04 0.0371
Onchocerca volvulus 0.0018 0.0039 0.0054
Leishmania major hypothetical protein, conserved 0.004 0.0295 0.1158
Trypanosoma cruzi CYC2-like cyclin, putative 0.0207 0.2245 1
Brugia malayi Pre-SET motif family protein 0.0209 0.2268 0.3326
Brugia malayi diacylglycerol kinase 0.0072 0.0672 0.0986
Brugia malayi mbt repeat family protein 0.0049 0.04 0.0586
Trichomonas vaginalis cyclin D, putative 0.0037 0.0257 0.074
Schistosoma mansoni protein kinase C mu 0.0072 0.0672 0.0651
Loa Loa (eye worm) hypothetical protein 0.0072 0.0672 0.0986
Loa Loa (eye worm) hypothetical protein 0.0082 0.0785 0.1151
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0079 0.0752 0.0733
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0111 0.0324
Plasmodium vivax calcium-dependent protein kinase, putative 0.0074 0.0689 0.3396
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0182 0.1951 0.1967
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0116 0.118 0.5172
Trichomonas vaginalis cyclins, putative 0.0207 0.2245 0.7478
Loa Loa (eye worm) hypothetical protein 0.0201 0.2177 0.3192
Echinococcus multilocularis cyclin A3 4 0.0037 0.0257 0.0224
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0545 0.08
Entamoeba histolytica zinc finger protein, putative 0.0023 0.0092 0.0256
Echinococcus granulosus myotubularin protein 13 0.0077 0.0724 0.0705
Plasmodium falciparum flap endonuclease 1 0.0026 0.0129 0.0469
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0785 0.3899
Loa Loa (eye worm) AGC/NDR protein kinase 0.0086 0.083 0.1217
Echinococcus multilocularis cyclin G2 0.0037 0.0257 0.0224
Echinococcus granulosus cyclin y 0.0037 0.0257 0.0224
Echinococcus granulosus cyclin G2 0.0037 0.0257 0.0224
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0086 0.083 0.0813
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0037 0.0257 0.0621
Entamoeba histolytica hypothetical protein 0.0074 0.0687 0.2002
Echinococcus granulosus Protein kinase C brain isozyme 0.0294 0.326 0.3313
Echinococcus multilocularis cyclins 0.0153 0.1613 0.1619
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0214 0.232 0.3402
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Onchocerca volvulus Chorion peroxidase homolog 0.0599 0.682 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.2557 0.3749
Giardia lamblia G2/mitotic-specific cyclin B 0.0207 0.2245 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0724 0.1062
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0072 0.0672 0.0986
Mycobacterium ulcerans beta-lactamase 0.0082 0.0785 0.0527
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Echinococcus granulosus importin subunit beta 1 0.0033 0.0213 0.0178
Schistosoma mansoni cyclin d 0.0037 0.0257 0.0224
Onchocerca volvulus 0.0301 0.3338 0.4892
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0307 0.3413 0.347
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0037 0.0257 0.0224
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0785 0.0527
Loa Loa (eye worm) cyclin domain-containing protein 0.0037 0.0257 0.0378
Schistosoma mansoni cyclin k 0.0037 0.0257 0.0224
Giardia lamblia Cyclin B-like protein 0.0037 0.0257 0.0688
Schistosoma mansoni importin beta-1 0.0033 0.0213 0.0178
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.0468 0.1359
Echinococcus multilocularis calpain 0.002 0.0061 0.0022
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0182 0.1951 0.544
Brugia malayi CXXC zinc finger family protein 0.0089 0.0869 0.1274
Echinococcus granulosus geminin 0.0174 0.1863 0.1876
Loa Loa (eye worm) hypothetical protein 0.0301 0.3338 0.4894
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0481 0.5444 0.7983
Loa Loa (eye worm) hypothetical protein 0.0028 0.0151 0.0221
Echinococcus granulosus calpain A 0.002 0.0061 0.0022
Echinococcus multilocularis neurogenic locus protein delta 0.0062 0.0545 0.0521
Plasmodium falciparum calcium-dependent protein kinase 4 0.0074 0.0689 0.3396
Schistosoma mansoni hypothetical protein 0.0032 0.0198 0.0164
Echinococcus multilocularis protein jagged 1 0.0062 0.0545 0.0521
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0555 0.6307 0.6447
Schistosoma mansoni calpain-7 (C02 family) 0.0023 0.0095 0.0057
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0039 0.0058
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0181 0.1937 0.2839
Brugia malayi Cyclin, N-terminal domain containing protein 0.0274 0.3028 0.444
Toxoplasma gondii histone lysine methyltransferase SET1 0.017 0.1815 0.5052
Echinococcus granulosus mitogen activated protein kinase 3 0.0116 0.118 0.1173
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0063 0.0079
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0098 0.006
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0111 0.0373
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.04 0.0371
Loa Loa (eye worm) glutaminase 0.0271 0.2988 0.4382
Giardia lamblia Cyclin A 0.0153 0.1613 0.704
Entamoeba histolytica cyclin, domain containing protein 0.0037 0.0257 0.074
Brugia malayi Tnks protein 0.0023 0.0092 0.0135
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0273 0.04
Toxoplasma gondii ABC1 family protein 0.0082 0.0785 0.2121
Entamoeba histolytica PH domain containing protein kinase, putative 0.0163 0.1733 0.5071
Brugia malayi Variant SH3 domain containing protein 0.0072 0.0672 0.0986
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0061 0.0097
Loa Loa (eye worm) cysteine protease 0.0018 0.0039 0.0058
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0111 0.0203
Echinococcus multilocularis cyclin G2 0.0037 0.0257 0.0224
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Toxoplasma gondii AGC kinase 0.0182 0.1951 0.544
Trichomonas vaginalis AGC family protein kinase 0.009 0.0882 0.2857
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0129 0.0407
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0039 0.0058
Brugia malayi EGF-like domain containing protein 0.0062 0.0545 0.08
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0098 0.006
Echinococcus granulosus cyclin dependent kinase 0.0055 0.0468 0.0441
Echinococcus multilocularis cyclins 0.0153 0.1613 0.1619
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.1937 0.1952
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0771 0.0753
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.04 0.0371
Toxoplasma gondii AGC kinase 0.0182 0.1951 0.544
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1002 0.1469
Schistosoma mansoni calpain C (C02 family) 0.002 0.0061 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0063 0.0079
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0129 0.0092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0198 0.0164
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0086 0.083 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0092 0.018
Loa Loa (eye worm) hypothetical protein 0.0072 0.0672 0.0986
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0111 0.0229
Echinococcus granulosus protein jagged 2 0.0062 0.0545 0.0521
Echinococcus granulosus muscleblind protein 0.044 0.497 0.5072
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0062 0.0545 0.08
Leishmania major cyclin 0.0207 0.2245 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0116 0.118 0.173
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0061 0.0097
Onchocerca volvulus 0.0018 0.0039 0.0054
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0129 0.0469
Plasmodium falciparum cyclin 1 0.0037 0.0257 0.1141
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0479 0.0452
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0182 0.1951 0.8669
Schistosoma mansoni calpain-7 (C02 family) 0.0023 0.0095 0.0057
Echinococcus multilocularis protein jagged 1 0.0062 0.0545 0.0521
Entamoeba histolytica cyclin family protein 0.0153 0.1613 0.4718
Echinococcus multilocularis cyclins 0.0153 0.1613 0.1619
Loa Loa (eye worm) hypothetical protein 0.0069 0.063 0.0924
Loa Loa (eye worm) animal heme peroxidase 0.0599 0.682 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0092 0.018
Echinococcus multilocularis lamin dm0 0.0028 0.0151 0.0114
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0061 0.0097
Loa Loa (eye worm) hypothetical protein 0.0258 0.2844 0.417
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0074 0.0689 0.101
Echinococcus granulosus calpain 0.002 0.0061 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0689 0.2202
Echinococcus granulosus neurogenic locus notch protein 0.0062 0.0545 0.0521
Echinococcus granulosus fibropellin Ia 0.0062 0.0545 0.0521
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0086 0.083 0.0813
Schistosoma mansoni hypothetical protein 0.0306 0.3402 0.3459
Trypanosoma cruzi mitotic cyclin, putative 0.0037 0.0257 0.0989
Entamoeba histolytica PH domain containing protein kinase, putative 0.0186 0.2003 0.5863
Echinococcus multilocularis tankyrase 0.0023 0.0092 0.0054
Schistosoma mansoni hypothetical protein 0.0062 0.0545 0.0521
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0055 0.0473 0.1969
Trichomonas vaginalis AGC family protein kinase 0.009 0.0882 0.2857
Brugia malayi intracellular kinase 0.0055 0.0473 0.0694
Echinococcus multilocularis calpain 5 0.0027 0.0141 0.0104
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0173 0.1852 0.1865
Brugia malayi hypothetical protein 0.0074 0.0687 0.1008
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0182 0.1951 0.1967
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0473 0.0694
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0207 0.2245 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Echinococcus multilocularis neurogenic locus notch protein 0.0062 0.0545 0.0521
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0273 0.122
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0319 0.3553 1
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.083 0.0813
Plasmodium falciparum protein kinase 5 0.0055 0.0468 0.2244
Trypanosoma brucei rac serine-threonine kinase, putative 0.009 0.0882 0.376
Trichomonas vaginalis cyclin D, putative 0.0153 0.1613 0.5336
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0039 0.0058
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0055 0.0468 0.1945
Loa Loa (eye worm) hypothetical protein 0.0301 0.3338 0.4894
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0567 0.2395
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0273 0.04
Onchocerca volvulus 0.0018 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0301 0.3338 0.4894
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0182 0.1951 0.8656
Loa Loa (eye worm) cyclin domain-containing protein 0.0274 0.3028 0.444
Loa Loa (eye worm) hypothetical protein 0.044 0.497 0.7287
Onchocerca volvulus Peroxidasin homolog 0.0599 0.682 1
Brugia malayi protein kinase C3,putative 0.0171 0.182 0.2668
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1002 0.1469
Entamoeba histolytica hypothetical protein 0.0023 0.0092 0.0256
Brugia malayi hypothetical protein 0.0599 0.682 1
Schistosoma mansoni hypothetical protein 0.0074 0.0687 0.0667
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.063 0.0924
Echinococcus multilocularis unc 13 (munc13) 0.0079 0.0752 0.0733
Leishmania major cathepsin L-like protease 0.0069 0.0638 0.2714
Echinococcus multilocularis muscleblind protein 1 0.044 0.497 0.5072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0161
Trypanosoma brucei poly(adp-ribose) polymerase 0.0169 0.1797 0.795
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0151 0.0221
Onchocerca volvulus Cyclin L homolog 0.0037 0.0257 0.0374
Loa Loa (eye worm) hypothetical protein 0.0207 0.2245 0.3291
Brugia malayi Protein kinase domain containing protein 0.0086 0.083 0.1217
Schistosoma mansoni hypothetical protein 0.0022 0.0087 0.0049
Onchocerca volvulus 0.0133 0.1375 0.2014
Trypanosoma cruzi cyclin, putative 0.0207 0.2245 1
Brugia malayi Protein kinase domain containing protein 0.0086 0.083 0.1217
Trichomonas vaginalis cyclin A, putative 0.0037 0.0257 0.074
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0129 0.0086
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0074 0.0689 0.3396
Trypanosoma cruzi mitotic cyclin, putative 0.0037 0.0257 0.0989
Brugia malayi Animal haem peroxidase family protein 0.0599 0.682 1
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0169 0.1797 0.1808
Echinococcus granulosus protein kinase C gamma type 0.0222 0.2414 0.2443
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0257 0.0378
Echinococcus multilocularis cyclin B 0.0207 0.2245 0.2268
Brugia malayi EGF-like domain containing protein 0.0062 0.0545 0.08
Brugia malayi MAP kinase sur-1 0.0116 0.118 0.173
Echinococcus granulosus slit 2 protein 0.0062 0.0545 0.0521
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Echinococcus granulosus N chimaerin 0.0072 0.0672 0.0651
Brugia malayi cyclin fold protein 1 variant b 0.0037 0.0257 0.0378
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0689 0.0668
Loa Loa (eye worm) hypothetical protein 0.0133 0.1375 0.2016
Echinococcus multilocularis poly (ADP ribose) polymerase 0.007 0.0649 0.0628
Brugia malayi Ras association domain family 1 isoform A 0.0072 0.0672 0.0986
Loa Loa (eye worm) hypothetical protein 0.0037 0.0257 0.0378
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0257 0.0378
Onchocerca volvulus 0.0207 0.2245 0.3289
Giardia lamblia Cyclin fold protein 1, putative 0.0037 0.0257 0.0688
Onchocerca volvulus 0.0028 0.0151 0.0217
Echinococcus granulosus tankyrase 0.0023 0.0092 0.0054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0198 0.0291
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0079 0.0752 0.0733
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0061 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.1613 0.5336
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0061 0.0097
Schistosoma mansoni diacylglycerol kinase theta 0.0072 0.0672 0.0651
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0406 0.1045
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0257 0.0378
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0689 0.0668
Echinococcus granulosus unc 13 munc13 0.0079 0.0752 0.0733
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0479 0.0452
Entamoeba histolytica cyclin, domain containing protein 0.0037 0.0257 0.074
Loa Loa (eye worm) ctsf protein 0.0018 0.0039 0.0058
Loa Loa (eye worm) cyclin domain-containing protein 0.0294 0.326 0.4781
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0037 0.0257 0.0621
Loa Loa (eye worm) animal heme peroxidase 0.0599 0.682 1
Onchocerca volvulus 0.0037 0.0257 0.0374
Brugia malayi protein kinase C II. 0.0315 0.3511 0.5148
Echinococcus granulosus poly (ADP ribose) polymerase 0.0048 0.0383 0.0354
Echinococcus multilocularis cyclins 0.0153 0.1613 0.1619
Onchocerca volvulus Putative cubilin 0.0062 0.0545 0.0797
Loa Loa (eye worm) hypothetical protein 0.0072 0.0672 0.0986
Schistosoma mansoni hypothetical protein 0.0072 0.0672 0.0651
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0212
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0062 0.0545 0.0797
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.004 0.0295 0.1071
Giardia lamblia Hypothetical protein 0.0037 0.0257 0.0688
Loa Loa (eye worm) MBCTL1 0.0056 0.0479 0.0702
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0555 0.6307 0.6447
Schistosoma mansoni unc-13 (munc13) 0.0079 0.0752 0.0733
Mycobacterium ulcerans glutaminase 0.0271 0.2988 0.2792
Echinococcus multilocularis calcium dependent protein kinase 0.0065 0.059 0.0566
Trichomonas vaginalis AGC family protein kinase 0.0086 0.083 0.268
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0129 0.0304
Entamoeba histolytica Ran family GTPase 0.0024 0.0111 0.031
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0144 0.151 0.2214
Brugia malayi Muscle positioning protein 4 0.0062 0.0545 0.08
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Trichomonas vaginalis cyclin B, putative 0.0037 0.0257 0.074
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0061 0.0097
Brugia malayi Delta serrate ligand family protein 0.0062 0.0545 0.08
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0063 0.0079
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0182 0.1951 0.1967
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.014 0.0455
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0182 0.1951 0.1967
Schistosoma mansoni serine/threonine protein kinase 0.0315 0.3511 0.3571
Plasmodium falciparum calcium-dependent protein kinase 5 0.0074 0.0689 0.3396
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0077 0.0731 0.2345
Brugia malayi Protein kinase domain containing protein 0.0181 0.1937 0.2839
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0785 0.0527
Echinococcus granulosus protein kinase c iota type 0.0248 0.2724 0.2762
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.083 0.0813
Trypanosoma cruzi cyclin, putative 0.0207 0.2245 1
Onchocerca volvulus Peroxidase homolog 0.0599 0.682 1
Brugia malayi Animal haem peroxidase family protein 0.0599 0.682 1
Toxoplasma gondii exonuclease III APE 0.0038 0.0273 0.0663
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0307 0.3413 0.347
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0098 0.006
Mycobacterium ulcerans hypothetical protein 0.0082 0.0785 0.0527
Onchocerca volvulus 0.0018 0.0039 0.0054
Echinococcus multilocularis hypothetical protein 0.002 0.0061 0.0022
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0182 0.1951 0.8669
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0111 0.0162
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0111 0.0073
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0273 0.1057
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0257 0.0378
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0224 0.244 0.247
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0063 0.0079
Loa Loa (eye worm) cyclin domain-containing protein 0.0037 0.0257 0.0378
Brugia malayi Cyclin, N-terminal domain containing protein 0.0294 0.326 0.4781
Entamoeba histolytica hypothetical protein 0.0048 0.0383 0.111
Schistosoma mansoni notch 0.0062 0.0545 0.0521
Onchocerca volvulus 0.0079 0.0752 0.11
Echinococcus multilocularis geminin 0.0174 0.1863 0.1876
Brugia malayi intermediate filament protein 0.0028 0.0151 0.0221
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0151 0.0221
Toxoplasma gondii hypothetical protein 0.0037 0.0257 0.0621
Mycobacterium ulcerans lipase LipD 0.0082 0.0785 0.0527
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0055 0.0473 0.0447
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.04 0.0371
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0079 0.0754 0.374
Onchocerca volvulus 0.0082 0.0785 0.1148
Brugia malayi Protein kinase domain containing protein 0.009 0.0882 0.1293
Giardia lamblia Kinase, CMGC CDK 0.0055 0.0468 0.1676
Loa Loa (eye worm) cyclin C 0.0037 0.0257 0.0378
Schistosoma mansoni protein kinase C 0.0079 0.0752 0.0733
Trichomonas vaginalis esterase, putative 0.0082 0.0785 0.2528
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0406 0.192
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0468 0.0441
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0072 0.0672 0.0986
Loa Loa (eye worm) hypothetical protein 0.0033 0.0213 0.0312
Trichomonas vaginalis cyclins, putative 0.0207 0.2245 0.7478
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0086 0.083 0.1217
Echinococcus multilocularis cyclin 0.0037 0.0257 0.0224
Onchocerca volvulus 0.0018 0.0039 0.0054
Echinococcus granulosus calpain 7 C02 family 0.002 0.0061 0.0022
Echinococcus multilocularis notch 0.0062 0.0545 0.0521
Leishmania major cathepsin L-like protease 0.0069 0.0638 0.2714
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0871 1 1
Echinococcus granulosus poly (ADP ribose) polymerase 0.0095 0.094 0.0927
Trichomonas vaginalis cyclin D, putative 0.0153 0.1613 0.5336
Schistosoma mansoni notch 0.0062 0.0545 0.0521
Leishmania major protein kinase A catalytic subunit isoform 2 0.0182 0.1951 0.8669
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0473 0.1374
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0074 0.0689 0.101
Leishmania major importin beta-1 subunit, putative 0.0027 0.014 0.0455
Trichomonas vaginalis cyclins, putative 0.0037 0.0257 0.074
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0072 0.0672 0.0986
Loa Loa (eye worm) AGC/PKN protein kinase 0.0086 0.083 0.1217
Echinococcus granulosus cyclin G2 0.0037 0.0257 0.0224
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Echinococcus granulosus peroxidasin 0.0599 0.682 0.6975
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0468 0.1455
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0092 0.018
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0037 0.0257 0.0224
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0055 0.0468 0.0441
Schistosoma mansoni protein kinase C mu 0.0214 0.232 0.2346
Giardia lamblia Kinase, AGC PKA 0.0182 0.1951 0.8625
Echinococcus multilocularis peroxidasin 0.0599 0.682 0.6975
Schistosoma mansoni hypothetical protein 0.0037 0.0257 0.0224
Brugia malayi hypothetical protein 0.0258 0.2844 0.417
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.04 0.0583
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0059 0.0513 0.0488
Echinococcus granulosus protein kinase c eta type 0.0072 0.0672 0.0651
Echinococcus multilocularis serine threonine protein kinase 0.0222 0.2414 0.2443
Echinococcus granulosus cyclin A3 4 0.0037 0.0257 0.0224
Schistosoma mansoni hypothetical protein 0.0062 0.0545 0.0521
Loa Loa (eye worm) hypothetical protein 0.0169 0.1797 0.2635
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0098 0.006
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.0058
Leishmania major cathepsin L-like protease 0.0069 0.0638 0.2714
Brugia malayi Protein kinase domain containing protein 0.0015 0.0002 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0785 0.2528
Entamoeba histolytica protein kinase, putative 0.0055 0.0473 0.1374
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0087 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0092 0.018
Entamoeba histolytica hypothetical protein 0.0074 0.0687 0.2002
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0039 0.0054
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0638 0.2714
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0162 0.0126
Echinococcus multilocularis neurogenic locus protein delta 0.0062 0.0545 0.0521
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0198 0.0164
Echinococcus granulosus protein kinase shaggy 0.0055 0.0473 0.0447
Schistosoma mansoni cyclins 0.0153 0.1613 0.1619
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0116 0.118 0.5172
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Onchocerca volvulus Slit protein homolog 0.0062 0.0545 0.0797
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0182 0.1951 0.2861
Brugia malayi mbt repeat family protein 0.0049 0.04 0.0586
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0182 0.1951 0.8656
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0182 0.1951 0.1967
Echinococcus granulosus NDR protein kinase 0.0086 0.083 0.0813
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0162 0.0126
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0043 0.0324 0.0293
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Brugia malayi EGF-like domain containing protein 0.0062 0.0545 0.08
Schistosoma mansoni ap endonuclease 0.0038 0.0273 0.024
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0158 0.0231
Trichomonas vaginalis AGC family protein kinase 0.009 0.0882 0.2857
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0086 0.083 0.0813
Trypanosoma brucei mitotic cyclin 6 0.0207 0.2245 1
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0037 0.0257 0.1141
Entamoeba histolytica cyclin, putative 0.0153 0.1613 0.4718
Echinococcus granulosus microtubule associated protein 2 0.0752 0.8605 0.8811
Onchocerca volvulus 0.0062 0.0545 0.0797
Echinococcus granulosus cpg binding protein 0.0094 0.0929 0.0915
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0224 0.244 0.247
Giardia lamblia Hypothetical protein 0.0037 0.0257 0.0688
Trypanosoma brucei cdc2-related kinase 3 0.0055 0.0468 0.1866
Schistosoma mansoni cyclin B 0.0207 0.2245 0.2268
Loa Loa (eye worm) hypothetical protein 0.0387 0.4341 0.6365
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0785 0.1151
Schistosoma mansoni microtubule-associated protein tau 0.0752 0.8605 0.8811
Mycobacterium tuberculosis Conserved protein 0.0082 0.0785 0.0527
Onchocerca volvulus Neurogenic locus notch homolog 0.0062 0.0545 0.0797
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0055 0.0468 0.1945
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.083 0.0813
Trichomonas vaginalis cyclin A, putative 0.0207 0.2245 0.7478
Trypanosoma cruzi DNA repair protein, putative 0.004 0.0295 0.1158
Echinococcus granulosus serine:threonine protein kinase N2 0.0086 0.083 0.0813
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0081 0.0771 0.0753
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0406 0.192
Echinococcus multilocularis cyclin b3 0.0153 0.1613 0.1619
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0129 0.0364
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0213 0.0493
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.0468 0.0441
Loa Loa (eye worm) RasGEF domain-containing protein 0.0073 0.0675 0.0989
Loa Loa (eye worm) hypothetical protein 0.0082 0.0785 0.1151
Schistosoma mansoni protein kinase 0.0555 0.6307 0.6447
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0785 0.2528
Trichomonas vaginalis cyclins, putative 0.0153 0.1613 0.5336
Echinococcus granulosus RNA directed DNA polymerase 0.0129 0.1331 0.1329
Schistosoma mansoni hypothetical protein 0.0037 0.0257 0.0224
Onchocerca volvulus 0.0062 0.0545 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0092 0.018
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0061 0.0097
Echinococcus multilocularis protein kinase c iota type 0.0248 0.2724 0.2762
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.118 0.3868
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0111 0.0162
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0687 0.0667
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0169 0.1797 0.797
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.014 0.034
Trichomonas vaginalis set domain proteins, putative 0.0238 0.2603 0.8692
Loa Loa (eye worm) hypothetical protein 0.0037 0.0257 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0257 0.074
Loa Loa (eye worm) animal heme peroxidase 0.0599 0.682 1
Echinococcus granulosus lamin 0.0028 0.0151 0.0114
Echinococcus multilocularis mitogen activated protein kinase 0.0116 0.118 0.1173
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0182 0.1951 0.8669
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0273 0.5
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0086 0.083 0.0813
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.014 0.034
Echinococcus granulosus protein jagged 1 0.0062 0.0545 0.0521
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0015 0.0002 0.0003
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0061 0.0022
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0273 0.024
Toxoplasma gondii hypothetical protein 0.0116 0.1182 0.3251
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0072 0.0672 0.0651
Loa Loa (eye worm) hypothetical protein 0.0053 0.0448 0.0657
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.0468 0.0687
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0141 0.1474 0.2161
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Onchocerca volvulus 0.0599 0.682 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0274 0.3028 0.3074
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.0058
Entamoeba histolytica protein kinase, putative 0.0023 0.0089 0.0247
Echinococcus granulosus G1:S specific cyclin D1 0.0037 0.0257 0.0224
Plasmodium vivax glycogen synthase kinase 3, putative 0.0055 0.0473 0.2271
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0074 0.0689 0.0668
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.118 0.3868
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0062 0.0545 0.0521
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0513 0.0488
Mycobacterium tuberculosis Conserved protein 0.0082 0.0785 0.0527
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0257 0.0989
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0785 0.3316
Schistosoma mansoni ap endonuclease 0.0038 0.0273 0.024
Schistosoma mansoni survival motor neuron protein 0.0053 0.0442 0.0414
Onchocerca volvulus 0.0238 0.2603 0.3814
Schistosoma mansoni cpg binding protein 0.0094 0.0929 0.0915
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0161
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0074 0.0689 0.101
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0116 0.118 0.3246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Echinococcus multilocularis raf serine:threonine protein kinase 0.0072 0.0672 0.0651
Trichomonas vaginalis AGC family protein kinase 0.009 0.0882 0.2857
Plasmodium falciparum glycogen synthase kinase 3 0.0055 0.0473 0.2271
Brugia malayi diacylglycerol kinase 0.0072 0.0672 0.0986
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0058
Brugia malayi calpain 5 0.0021 0.007 0.0103
Trypanosoma cruzi cyclin 9, putative 0.0037 0.0257 0.0989
Echinococcus multilocularis cyclins 0.0153 0.1613 0.1619
Mycobacterium tuberculosis Conserved protein 0.0082 0.0785 0.0527
Echinococcus multilocularis mitogen activated protein kinase 3 0.0116 0.118 0.1173
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0129 0.0189
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0081 0.0771 0.0753
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0785 0.0767
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Loa Loa (eye worm) hypothetical protein 0.0054 0.0458 0.0672
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0063 0.0079
Brugia malayi calpain family protein 1 0.0053 0.0448 0.0657
Loa Loa (eye worm) hypothetical protein 0.004 0.0295 0.0432
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0039 0.0054
Schistosoma mansoni slit 0.0062 0.0545 0.0521
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0063 0.0079
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0406 0.1665
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0086 0.083 0.0813
Trypanosoma brucei protein kinase, putative 0.0116 0.118 0.5125
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Echinococcus granulosus flap endonuclease 1 0.0026 0.0129 0.0092
Onchocerca volvulus 0.0205 0.2221 0.3254
Trichomonas vaginalis AGC family protein kinase 0.0182 0.1951 0.6483
Plasmodium vivax cyclin 4, putative 0.0037 0.0257 0.1141
Echinococcus multilocularis neural cadherin 0.0062 0.0545 0.0521
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0468 0.0441
Schistosoma mansoni cpg binding protein 0.0089 0.0869 0.0854
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0074 0.0689 0.1848
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0479 0.0452
Entamoeba histolytica protein kinase, putative 0.0086 0.083 0.242
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0086 0.083 0.1217
Echinococcus granulosus delta-like protein 1 0.0062 0.0545 0.0521
Loa Loa (eye worm) hypothetical protein 0.0032 0.0196 0.0288
Plasmodium falciparum calcium-dependent protein kinase 3 0.0074 0.0689 0.3396
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0785 0.0527
Echinococcus granulosus poly (ADP ribose) polymerase 0.0048 0.0383 0.0354
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0039 0.01
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Onchocerca volvulus 0.0062 0.0545 0.0797
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0257 0.0378
Brugia malayi Pleckstrin Homology Domain 0.0077 0.0724 0.1062
Brugia malayi hypothetical protein 0.0037 0.0257 0.0378
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0177 0.1897 0.2781
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.04 0.0586
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0146 0.1531 0.1534
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0473 0.1472
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0273 0.097
Loa Loa (eye worm) hypothetical protein 0.0133 0.1375 0.2016
Onchocerca volvulus Peroxidase homolog 0.0599 0.682 1
Leishmania major cyclin 9, putative 0.0037 0.0257 0.0989
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0061 0.0097
Giardia lamblia Kinase, CMGC MAPK 0.0116 0.118 0.5011
Brugia malayi RNA, U transporter 1 0.0094 0.0925 0.1356
Schistosoma mansoni unc-13 (munc13) 0.0079 0.0752 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0092 0.018
Echinococcus granulosus Rac GTPase activating protein 1 0.0072 0.0672 0.0651
Echinococcus multilocularis serine:threonine protein kinase N2 0.0236 0.2585 0.2619
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0111 0.0324
Onchocerca volvulus Cyclin L homolog 0.0037 0.0257 0.0374
Trypanosoma brucei cdc2-related kinase 1 0.0055 0.0468 0.1866
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0053 0.0448 0.042
Echinococcus granulosus protein jagged 1 0.0062 0.0545 0.0521
Loa Loa (eye worm) fibroinase 0.0018 0.0039 0.0058
Toxoplasma gondii cyclin dependent kinase binding protein 0.0037 0.0257 0.0621
Brugia malayi hypothetical protein 0.005 0.0406 0.0596
Echinococcus granulosus cyclin B3 1 0.0153 0.1613 0.1619
Brugia malayi RhoGAP domain containing protein 0.0072 0.0672 0.0986
Onchocerca volvulus 0.0089 0.0869 0.1271
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0284 0.0251
Onchocerca volvulus 0.0033 0.0213 0.031
Brugia malayi notch-like transmembrane receptor 0.0062 0.0545 0.08
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0182 0.1951 1
Leishmania major protein kinase A catalytic subunit isoform 1 0.0182 0.1951 0.8669
Toxoplasma gondii AGC kinase 0.0086 0.083 0.2249
Schistosoma mansoni laminin gamma-3 chain 0.0062 0.0545 0.0521
Loa Loa (eye worm) Notch2 0.0062 0.0545 0.08
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0785 0.1151
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0063 0.0079
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0473 0.0694
Giardia lamblia High cysteine protein 0.0062 0.0545 0.2038
Echinococcus granulosus snurportin 1 0.0353 0.3951 0.4023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0785 0.0767
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.04 0.0371
Brugia malayi Cyclin, N-terminal domain containing protein 0.0207 0.2245 0.3291
Loa Loa (eye worm) hypothetical protein 0.0082 0.0785 0.1151
Brugia malayi EGF-like domain containing protein 0.0062 0.0545 0.08
Brugia malayi Flap endonuclease-1 0.0026 0.0129 0.0189
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Schistosoma mansoni serine/threonine kinase 0.0086 0.083 0.0813
Echinococcus granulosus poly adp ribose polymerase 2 0.0169 0.1797 0.1808
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0162 0.0237
Brugia malayi Blistered cuticle protein 3 0.0599 0.682 1
Brugia malayi MH2 domain containing protein 0.0116 0.1178 0.1727
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0513 0.0488
Loa Loa (eye worm) hypothetical protein 0.0046 0.0369 0.0542
Loa Loa (eye worm) cyclin domain-containing protein 0.0037 0.0257 0.0378
Onchocerca volvulus DNA ligase 3 homolog 0.004 0.0295 0.0429
Onchocerca volvulus 0.021 0.2273 0.3331
Schistosoma mansoni calpain (C02 family) 0.002 0.0061 0.0022
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1178 0.1727
Echinococcus granulosus protein jagged 2 0.0062 0.0545 0.0521
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.118 0.3868
Leishmania major mitotic cyclin, putative 0.0037 0.0257 0.0989
Schistosoma mansoni mixed-lineage leukemia protein mll 0.019 0.2051 0.2069
Schistosoma mansoni cyclin G2 0.0037 0.0257 0.0224
Echinococcus granulosus Cyclin L1 0.0037 0.0257 0.0224
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0689 0.0668
Echinococcus multilocularis GPCR, family 2 0.0032 0.0198 0.0164
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0479 0.0702
Onchocerca volvulus 0.0062 0.0545 0.0797
Schistosoma mansoni rac gtpase activating protein 0.0072 0.0672 0.0651
Schistosoma mansoni lamin 0.0028 0.0151 0.0114
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0074 0.0689 0.1848
Brugia malayi Cadherin domain containing protein 0.0062 0.0545 0.08
Toxoplasma gondii EGF family domain-containing protein 0.0062 0.0545 0.144
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0785 0.0527
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0196 0.0161
Trichomonas vaginalis cyclin B, putative 0.0207 0.2245 0.7478
Loa Loa (eye worm) AGC/PKA protein kinase 0.0182 0.1951 0.2861
Schistosoma mansoni diacylglycerol kinase theta 0.0072 0.0672 0.0651
Entamoeba histolytica hypothetical protein 0.0023 0.0092 0.0256
Onchocerca volvulus Dual oxidase homolog 0.0599 0.682 1
Schistosoma mansoni notch 0.0062 0.0545 0.0521
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0284 0.0416
Brugia malayi WGR domain containing protein 0.0307 0.3413 0.5004
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.0468 0.0687
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0129 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0092 0.018
Schistosoma mansoni hypothetical protein 0.0053 0.0442 0.0414
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0785 0.338
Echinococcus multilocularis cyclins 0.0153 0.1613 0.1619
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0307 0.3413 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0074 0.0689 0.2875
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0224 0.244 0.247
Echinococcus granulosus WGR domain containing protein 0.0095 0.094 0.0927
Echinococcus granulosus neural cadherin 0.0062 0.0545 0.0521
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0063 0.0079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0224 0.244 0.3578
Onchocerca volvulus 0.0599 0.682 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0196 0.0446
Brugia malayi GCC2 and GCC3 family protein 0.0062 0.0545 0.08
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0524 0.595 0.5836
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Echinococcus multilocularis cyclin dependent kinase 0.0055 0.0468 0.0441
Schistosoma mansoni hypothetical protein 0.0032 0.0198 0.0164
Schistosoma mansoni cyclin l 0.0037 0.0257 0.0224
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0353 0.3951 0.5793
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0672 0.0651
Brugia malayi beta-lactamase family protein 0.0082 0.0785 0.1151
Echinococcus granulosus cyclins 0.0037 0.0257 0.0224
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0182 0.1951 0.8656
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0111 0.0073
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0406 0.1665
Toxoplasma gondii diacylglycerol kinase, putative 0.0072 0.0672 0.1801
Plasmodium vivax calpain, putative 0.002 0.0061 0.0112
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Loa Loa (eye worm) cyclin domain-containing protein 0.0037 0.0257 0.0378
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0037 0.0257 0.0224
Brugia malayi Animal haem peroxidase family protein 0.0599 0.682 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Loa Loa (eye worm) beta-lactamase 0.0082 0.0785 0.1151
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0545 0.08
Echinococcus multilocularis cyclins 0.0153 0.1613 0.1619
Trichomonas vaginalis AGC family protein kinase 0.009 0.0882 0.2857
Loa Loa (eye worm) glutaminase 2 0.0271 0.2988 0.4382
Echinococcus multilocularis cyclin y 0.0037 0.0257 0.0224
Loa Loa (eye worm) hypothetical protein 0.044 0.497 0.7287
Trichomonas vaginalis cyclins, putative 0.0207 0.2245 0.7478
Schistosoma mansoni hypothetical protein 0.0069 0.063 0.0608
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0545 0.08
Trypanosoma brucei DNA repair protein, putative 0.004 0.0295 0.1071
Leishmania major DNA repair protein, putative 0.004 0.0295 0.1158
Echinococcus multilocularis neurogenic locus notch protein 4 0.0062 0.0545 0.0521
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.083 0.0813
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0481 0.5444 0.7983
Onchocerca volvulus 0.0032 0.0196 0.0284
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0072 0.0672 0.0651
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0055 0.0468 0.1221
Brugia malayi WGR domain containing protein 0.0169 0.1797 0.2635
Leishmania major GTP-binding protein, putative 0.0024 0.0111 0.0324
Brugia malayi glutaminase DH11.1 0.0271 0.2988 0.4382
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0315 0.3511 0.5148
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.04 0.0371
Schistosoma mansoni notch 0.0062 0.0545 0.0521
Brugia malayi Cyclin, N-terminal domain containing protein 0.0207 0.2245 0.3291
Loa Loa (eye worm) hypothetical protein 0.0047 0.0377 0.0553
Trichomonas vaginalis importin beta-1, putative 0.0027 0.014 0.034
Schistosoma mansoni peroxidasin 0.0599 0.682 0.6975
Echinococcus granulosus cyclins 0.0153 0.1613 0.1619
Trypanosoma brucei mitotic cyclin 0.0037 0.0257 0.0901
Onchocerca volvulus 0.0018 0.0039 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0687 0.0667
Onchocerca volvulus 0.0053 0.0442 0.0645
Onchocerca volvulus 0.0082 0.0785 0.1148
Echinococcus multilocularis cyclin k 0.0037 0.0257 0.0224
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.04 0.0371
Echinococcus multilocularis protein kinase c epsilon type 0.0315 0.3511 0.3571
Trichomonas vaginalis cyclin B, putative 0.0037 0.0257 0.074
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0063 0.0079
Echinococcus granulosus cyclins 0.0153 0.1613 0.1619
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0037 0.0257 0.1141
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0473 0.17
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0294 0.326 0.3313
Brugia malayi Animal haem peroxidase family protein 0.0599 0.682 1
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0169 0.1797 0.797
Schistosoma mansoni protein kinase 0.0555 0.6307 0.6447
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0257 0.1141
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0116 0.118 0.5172
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0687 0.0667
Echinococcus multilocularis Rac GTPase activating protein 1 0.0072 0.0672 0.0651
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.2844 0.2885
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0273 0.0758
Brugia malayi Peroxidasin 0.0599 0.682 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0785 0.1151
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0214 0.232 0.3402
Entamoeba histolytica cysteine protease, putative 0.0018 0.0039 0.01
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0638 0.2714
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0257 0.0378
Loa Loa (eye worm) CYL-1 protein 0.0037 0.0257 0.0378
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Plasmodium vivax protein kinase Crk2 0.0055 0.0468 0.2244
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.118 0.1173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0224 0.244 0.247
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.1951 0.1967
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0689 0.0668
Plasmodium falciparum calcium-dependent protein kinase 1 0.0074 0.0689 0.3396
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.0468 0.0441
Trichomonas vaginalis cyclin B3, putative 0.0037 0.0257 0.074
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0406 0.192
Schistosoma mansoni hypothetical protein 0.0062 0.0545 0.0521
Echinococcus multilocularis dnaJ subfamily B 0.0851 0.9761 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0062 0.0545 0.0521
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0173 0.1852 0.1865
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0468 0.1455
Brugia malayi Importin beta-1 subunit 0.0033 0.0213 0.0312
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0689 0.0668
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0182 0.1951 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.009 0.0882 0.1293
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0273 0.0791
Schistosoma mansoni intermediate filament proteins 0.0028 0.0151 0.0114
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0059 0.0513 0.0488
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.326 0.3313
Echinococcus granulosus GPCR family 2 0.0032 0.0198 0.0164
Brugia malayi Cyclin C 0.0037 0.0257 0.0378
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0473 0.17
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.326 0.3313
Trichomonas vaginalis cyclin B3, putative 0.0037 0.0257 0.074
Brugia malayi p70 ribosomal S6 kinase beta 0.0086 0.083 0.1217
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0464 0.1927
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0869 0.1274
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.1951 0.1967
Echinococcus multilocularis muscleblind protein 0.044 0.497 0.5072
Brugia malayi Protein kinase domain containing protein 0.0081 0.0771 0.1131
Brugia malayi Pre-SET motif family protein 0.0032 0.0196 0.0288
Loa Loa (eye worm) calpain family protein 1 0.0053 0.0448 0.0657
Schistosoma mansoni hypothetical protein 0.0174 0.1863 0.1876
Onchocerca volvulus Protein CNPPD1 homolog 0.0037 0.0257 0.0374
Loa Loa (eye worm) hypothetical protein 0.021 0.2273 0.3333
Entamoeba histolytica hypothetical protein 0.0037 0.0257 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0092 0.018
Loa Loa (eye worm) animal heme peroxidase 0.0599 0.682 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0063 0.0079
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0785 0.0527
Echinococcus granulosus calpain 5 0.0027 0.0141 0.0104
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0213 0.0178
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0198 0.0164
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0055 0.0473 0.1235
Schistosoma mansoni hypothetical protein 0.0174 0.1863 0.1876
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0196 0.0161
Brugia malayi Protein kinase c protein 2 0.0217 0.2356 0.3454
Echinococcus multilocularis cpg binding protein 0.0094 0.0929 0.0915
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0161 0.0125
Echinococcus multilocularis cyclin y 0.0037 0.0257 0.0224
Brugia malayi Muscleblind-like protein 0.044 0.497 0.7287
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0092 0.018
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0074 0.0689 0.3396
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0055 0.0473 0.0447
Loa Loa (eye worm) hypothetical protein 0.0082 0.0785 0.1151
Echinococcus multilocularis serine:threonine protein kinase N2 0.0086 0.083 0.0813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0638 0.2643
Trichomonas vaginalis helicase, putative 0.002 0.0063 0.0079
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0785 0.2528
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0063 0.0079
Onchocerca volvulus 0.0055 0.0473 0.0691
Onchocerca volvulus Tankyrase homolog 0.0023 0.0092 0.0132
Echinococcus granulosus serine:threonine protein kinase N2 0.0159 0.1681 0.1689
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0224 0.244 0.3578
Loa Loa (eye worm) hypothetical protein 0.0182 0.1951 0.2861
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.0468 0.1945
Echinococcus granulosus dnaJ subfamily B 0.0851 0.9761 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0273 0.1057
Brugia malayi beta-lactamase family protein 0.0082 0.0785 0.1151
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0273 0.024
Loa Loa (eye worm) hypothetical protein 0.0056 0.0479 0.0702
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.0058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0785 0.0527
Echinococcus multilocularis cyclin t1 0.0037 0.0257 0.0224
Brugia malayi Hr1 repeat family protein 0.0086 0.083 0.1217
Brugia malayi EGF-like domain containing protein 0.0062 0.0545 0.08
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0273 0.122
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0198 0.0164
Echinococcus multilocularis calpain A 0.0059 0.0516 0.049
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0161
Entamoeba histolytica protein kinase, putative 0.009 0.0882 0.2573
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0257 0.074
Schistosoma mansoni hypothetical protein 0.0062 0.0545 0.0521
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.118 0.3868
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0072 0.0672 0.0651
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.0468 0.1359
Trichomonas vaginalis AGC family protein kinase 0.009 0.0882 0.2857
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0063 0.0079
Toxoplasma gondii cyclin 4, putative 0.0037 0.0257 0.0621
Brugia malayi Protein kinase domain containing protein 0.0055 0.0468 0.0687
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0785 0.0527
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0037 0.0257 0.0224
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0273 0.1057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0224 0.244 0.247
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0129 0.0407
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0098 0.006
Brugia malayi Cam kinase protein 1 0.0074 0.0689 0.101
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0074 0.0689 0.3396
Loa Loa (eye worm) raf kinase 0.0072 0.0672 0.0986
Schistosoma mansoni hypothetical protein 0.0062 0.0545 0.0521
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0416
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.0468 0.1945
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0273 0.5
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0182 0.1951 0.1967
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0072 0.0672 0.0986
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1178 0.1727
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0087 0.0049
Loa Loa (eye worm) calpain 0.002 0.0061 0.0089
Onchocerca volvulus 0.0028 0.0151 0.0217
Trichomonas vaginalis cyclin B, putative 0.0207 0.2245 0.7478
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0785 0.0767
Trichomonas vaginalis cyclin B, putative 0.0207 0.2245 0.7478
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0785 0.338
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0121 0.124 0.1818
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0689 0.0668
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0061 0.0097
Loa Loa (eye worm) hypothetical protein 0.0599 0.682 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0061 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0063 0.0079
Loa Loa (eye worm) hypothetical protein 0.0062 0.0545 0.08
Schistosoma mansoni protein kinase 0.0555 0.6307 0.6447

Activities

Activity type Activity value Assay description Source Reference
behavior (functional) W 0 Gross behavioral effects ascertained in mice; W indicates weak stimulant or depressant activity of little significance. ChEMBL. 3039136
ED50 (functional) = 17.4 mg kg-1 Antagonism of tetrabenazine(TBZ)-induced depression in mice measured for ptosis ChEMBL. 3039136
ED50 (functional) ~ 35 mg kg-1 Antagonism of tetrabenazine(TBZ)-induced depression measured in mice by motor activity ChEMBL. 3039136
Inhibition (functional) = 5 % Ability to inhibit the uptake of [3H]- serotonin(5-HT) 0.1 microM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 36 % Ability to inhibit the uptake of [3H]-dopamine (DA) 0.1 uM concentration at rat brain synaptosomes ChEMBL. 3039136
Ki (functional) ~ 100 nM Ability to inhibit the uptake of tritiated norepinephrine(NE) 0.1 uM concentration ChEMBL. 3039136

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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