Detailed information for compound 513105

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.255 | Formula: C10H12N8O2
  • H donors: 3 H acceptors: 5 LogP: -0.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [N-]=[N+]=N[C@@H]1C[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N
  • InChi: 1S/C10H12N8O2/c11-9-6-10(14-2-13-9)18(3-15-6)5-1-4(16-17-12)7(19)8(5)20/h2-5,7-8,19-20H,1H2,(H2,11,13,14)/t4-,5-,7-,8+/m1/s1
  • InChiKey: UPIWCZFYODCBAS-APOSLCTFSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0021 0.0011 0.0041
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0149 0.0215 0.206
Trypanosoma brucei hypothetical protein 0.0565 0.0882 0.5957
Plasmodium falciparum cysteine proteinase falcipain 1 0.0335 0.0513 0.5365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Brugia malayi cathepsin F-like cysteine proteinase 0.0149 0.0215 0.084
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.0317 0.1209
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0607 0.0949 0.3709
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0081
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Trypanosoma brucei trypanothione reductase 0.0097 0.0132 0.084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Echinococcus granulosus cathepsin l1 0.0607 0.0949 0.3709
Giardia lamblia Hypothetical protein 0.0149 0.0215 0.2219
Schistosoma mansoni DNA polymerase eta 0.0046 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.003 0.0232
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0073 0.0073
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0269 0.0408 0.2725
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.003 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0036 0.0764
Trypanosoma brucei calmodulin, putative 0.0094 0.0126 0.0804
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.9139
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Plasmodium vivax unspecified product 0.0149 0.0215 0.206
Echinococcus granulosus calpain 0.0666 0.1043 0.4075
Leishmania major kinesin, putative 0.037 0.0569 0.3825
Toxoplasma gondii cathepsin CPL 0.0607 0.0949 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0012 0.0045
Brugia malayi cathepsin L precursor 0.0149 0.0215 0.084
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.2104
Trypanosoma brucei calpain, putative 0.0296 0.045 0.3014
Echinococcus granulosus intermediate filament protein 0.0028 0.0021 0.0081
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0091 0.0357
Echinococcus multilocularis Calcium binding protein 0.0027 0.002 0.0077
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0149 0.0215 0.0215
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0008 0.0032
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Schistosoma mansoni thyroid hormone receptor 0.014 0.0201 0.0201
Brugia malayi Myosin regulatory light chain 1 0.0027 0.002 0.0077
Entamoeba histolytica grainin 2 0.0027 0.002 0.0123
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.003 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma cruzi calmodulin, putative 0.0094 0.0126 0.0462
Echinococcus multilocularis programmed cell death protein 0.0121 0.017 0.0662
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0018 0.0038
Entamoeba histolytica calmodulin, putative 0.0094 0.0126 0.1253
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0036 0.014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0073 0.0073
Echinococcus multilocularis musashi 0.0028 0.0021 0.0081
Toxoplasma gondii centrin family protein 0.0027 0.002 0.021
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0011 0.0101
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0149 0.0215 0.2219
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Brugia malayi Death domain containing protein 0.0015 0 0.00000002115
Trichomonas vaginalis calcineurin B subunit, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi cysteine proteinase, putative 0.0335 0.0513 0.1977
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0311 0.0474 0.3175
Trypanosoma brucei hypothetical protein, conserved 0.0344 0.0528 0.3544
Trypanosoma brucei centrin, putative 0.0094 0.0126 0.0804
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Leishmania major centrin, putative,caltractin, putative 0.0094 0.0126 0.0804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Giardia lamblia Cathepsin L-like protease 0.0149 0.0215 0.2219
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.002 0.0046
Echinococcus multilocularis neuronal calcium sensor 0.0094 0.0126 0.0492
Leishmania major small myristoylated protein-3, putative 0.0311 0.0474 0.3175
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0269 0.0408 0.2725
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0036 0.014
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0149 0.0215 0.206
Giardia lamblia Cysteine protease 0.0149 0.0215 0.2219
Brugia malayi RasGEF domain containing protein 0.0027 0.002 0.0077
Toxoplasma gondii preprocathepsin c precursor, putative 0.0149 0.0215 0.2266
Entamoeba histolytica hypothetical protein, conserved 0.0096 0.013 0.1292
Leishmania major receptor-type adenylate cyclase a-like protein 0.0213 0.0317 0.2104
Echinococcus multilocularis calpain 7 (C02 family) 0.0666 0.1043 0.4075
Brugia malayi beta-lactamase family protein 0.0037 0.0036 0.014
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0011 0.0041
Leishmania major small myristoylated protein 4, putative 0.0578 0.0902 0.6095
Leishmania major calmodulin, putative 0.0094 0.0126 0.0804
Schistosoma mansoni rab 0.0094 0.0126 0.0126
Schistosoma mansoni reticulocalbin 0.0096 0.013 0.013
Trypanosoma cruzi I/6 autoantigen, putative 0.0094 0.0126 0.0462
Brugia malayi calpain family protein 1 0.1447 0.2293 0.8959
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.0132 0.0513
Loa Loa (eye worm) myosin Light Chain family member 0.0029 0.0024 0.0092
Echinococcus multilocularis neurocalcin 0.0094 0.0126 0.0492
Brugia malayi Cytochrome P450 family protein 0.0027 0.002 0.0078
Trypanosoma brucei conserved protein 0.0222 0.0331 0.2204
Echinococcus multilocularis cathepsin L cysteine protease 0.0607 0.0949 0.3709
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.0652 0.6837
Plasmodium falciparum thioredoxin reductase 0.0097 0.0132 0.1318
Giardia lamblia Encystation-specific protease 0.0149 0.0215 0.2219
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0026 0.0018 0.0067
Toxoplasma gondii centrin, putative 0.0094 0.0126 0.1329
Brugia malayi Cathepsin L-like cysteine proteinase 0.0422 0.0652 0.2546
Giardia lamblia Cathepsin B precursor 0.0602 0.094 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Schistosoma mansoni neuronal calcium sensor 0.0094 0.0126 0.0126
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0011 0.0041
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0027 0.002 0.0188
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0623 0.0975 0.659
Loa Loa (eye worm) hypothetical protein 0.0186 0.0274 0.107
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.003 0.0086
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Onchocerca volvulus 0.0021 0.001 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.0513 0.5361
Plasmodium vivax serine-repeat antigen (SERA) 0.0149 0.0215 0.206
Loa Loa (eye worm) matrixin family protein 0.0048 0.0054 0.021
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.003 0.0117
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.003 0.0149
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0036 0.0293
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.003 0.003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.003 0.2629
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1613 0.2559 0.2559
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Trichomonas vaginalis calcium binding protein, putative 0.0094 0.0126 0.1253
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0607 0.0949 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0602 0.094 0.6355
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0036 0.0293
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0149 0.0215 0.2205
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0036 0.0293
Trypanosoma brucei antigen, putative 0.0666 0.1043 0.7057
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Plasmodium falciparum glutathione reductase 0.0097 0.0132 0.1318
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.5253
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Loa Loa (eye worm) cysteine protease 0.0607 0.0949 0.3709
Leishmania major calmodulin-like protein 0.0094 0.0126 0.0804
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0073 0.0284
Leishmania major i/6 autoantigen-like protein 0.0094 0.0126 0.0804
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0215 0.2197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0149 0.0215 0.2197
Loa Loa (eye worm) calmodulin-like protein 0.0094 0.0126 0.0492
Plasmodium vivax glutathione reductase, putative 0.0097 0.0132 0.1259
Onchocerca volvulus 0.0027 0.002 0.0161
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0027 0.002 0.0161
Loa Loa (eye worm) fibroinase 0.0607 0.0949 0.3709
Trypanosoma cruzi small myristoylated protein 1-2 0.0367 0.0564 0.2177
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0 0.00000002115
Leishmania major META domain containing protein 0.0213 0.0317 0.2104
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.0201 0.0785
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Schistosoma mansoni myosin light chain 0.0027 0.002 0.002
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0011 0.0041
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0021 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.0652 0.6837
Onchocerca volvulus 0.0607 0.0949 0.7741
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.0317 0.1209
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.0132 0.0513
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.0513 0.5361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0149 0.0215 0.2197
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0044
Leishmania major cysteine peptidase A (CPA) 0.0607 0.0949 0.6417
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.003 0.5
Giardia lamblia Cathepsin L-like protease 0.0149 0.0215 0.2219
Schistosoma mansoni myosin regulatory light chain 0.0027 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0422 0.0652 0.2546
Brugia malayi hypothetical protein 0.0126 0.0178 0.0693
Loa Loa (eye worm) hypothetical protein 0.0046 0.005 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.086 0.1354 0.9179
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.003 0.0086
Trichomonas vaginalis calmodulin-2, putative 0.0094 0.0126 0.1253
Toxoplasma gondii EF hand domain-containing protein 0.0027 0.002 0.021
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Brugia malayi Cathepsin L-like precursor 0.0422 0.0652 0.2546
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0269 0.0408 0.1567
Loa Loa (eye worm) hypothetical protein 0.0422 0.0652 0.2546
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0094 0.0126 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Brugia malayi Trypsin-like protease protein 5 0.0021 0.001 0.0038
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0094 0.0126 0.1253
Echinococcus granulosus cathepsin b 0.1613 0.2559 1
Brugia malayi fibroinase precursor 0.0149 0.0215 0.084
Plasmodium vivax SET domain protein, putative 0.006 0.0073 0.0695
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0149 0.0215 0.2197
Trypanosoma cruzi cysteine peptidase, putative 0.08 0.1258 0.49
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0221 0.033 0.8874
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0666 0.1043 0.4057
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0094 0.0126 0.0462
Schistosoma mansoni calmodulin 0.0094 0.0126 0.0126
Entamoeba histolytica grainin, putative 0.0096 0.013 0.1292
Schistosoma mansoni cathepsin B (C01 family) 0.0149 0.0215 0.0215
Schistosoma mansoni ef hand domain family member A2 0.0094 0.0126 0.0126
Trypanosoma brucei calpain-like protein, putative 0.0936 0.1475 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0149 0.0215 0.084
Toxoplasma gondii calmodulin CAM1 0.0096 0.013 0.1369
Plasmodium falciparum serine repeat antigen 7 0.0149 0.0215 0.2205
Onchocerca volvulus 0.0037 0.0036 0.0292
Trichomonas vaginalis calmodulin, putative 0.0096 0.013 0.1292
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0074
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0246 0.037 1
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Trypanosoma cruzi cysteine peptidase, putative 0.08 0.1258 0.49
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0036 0.0481
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0221 0.033 0.8908
Loa Loa (eye worm) glutathione reductase 0.0097 0.0132 0.0513
Trypanosoma cruzi cysteine proteinase, putative 0.0335 0.0513 0.1977
Brugia malayi Kringle domain containing protein 0.0021 0.0011 0.0041
Plasmodium vivax vivapain-3 0.0335 0.0513 0.4914
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0091 0.0091
Echinococcus granulosus dna polymerase kappa 0.002 0.0008 0.0032
Schistosoma mansoni lamin 0.0028 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0344 0.0528 0.2037
Trypanosoma brucei calpain-like protein, putative 0.0666 0.1043 0.7057
Echinococcus multilocularis centrin 2 0.0094 0.0126 0.0492
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.5253
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0752 0.118 0.7991
Leishmania major cathepsin L-like protease 0.08 0.1258 0.8525
Loa Loa (eye worm) calpain 0.0666 0.1043 0.4075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Brugia malayi Trypsin family protein 0.0021 0.001 0.0038
Onchocerca volvulus 0.0477 0.0741 0.6042
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.5136
Toxoplasma gondii cathepsin CPC1 0.0149 0.0215 0.2266
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Echinococcus granulosus cathepsin l cysteine peptidase 0.0607 0.0949 0.3709
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0126 0.0491
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Trypanosoma cruzi major cysteine proteinase, putative 0.0342 0.0524 0.2022
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0079 0.0104 0.0404
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0623 0.0975 0.3788
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.003 0.0232
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.154 0.2443 0.2442
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0936 0.1475 0.5748
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Leishmania major calmodulin, putative 0.0094 0.0126 0.0804
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0027 0.002 0.0161
Trichomonas vaginalis centrin, putative 0.0027 0.002 0.0123
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.2952
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1613 0.2559 1
Echinococcus granulosus Calcium binding protein 0.0027 0.002 0.0077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0126 0.0491
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.002 0.0045
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0094 0.0126 0.0492
Trypanosoma brucei kinesin, putative 0.037 0.0569 0.3825
Plasmodium falciparum serine repeat antigen 4 0.0149 0.0215 0.2205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Schistosoma mansoni hypothetical protein 0.0053 0.0062 0.0062
Trypanosoma cruzi small myristoylated protein 1-1 0.0367 0.0564 0.2177
Entamoeba histolytica calcium-binding protein, putative 0.0094 0.0126 0.1253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Trypanosoma cruzi calmodulin, putative 0.0094 0.0126 0.0462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0126 0.0126
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0936 0.1475 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0018 0.0113
Trichomonas vaginalis set domain proteins, putative 0.0477 0.0741 0.7785
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.003 0.0149
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0016 0.0061
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0021 0.001 0.0038
Brugia malayi hypothetical protein 0.0021 0.001 0.0038
Mycobacterium ulcerans hypothetical protein 0.0037 0.0036 0.3321
Trypanosoma cruzi cysteine peptidase, putative 0.0607 0.0949 0.3689
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0008 0.0032
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0036 0.0764
Mycobacterium tuberculosis Conserved protein 0.0037 0.0036 0.0764
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0666 0.1043 0.4057
Echinococcus multilocularis calpain A 0.1542 0.2446 0.9559
Onchocerca volvulus 0.0607 0.0949 0.7741
Echinococcus multilocularis Ankyrin 0.0015 0 0.0001
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0186 0.0274 0.107
Loa Loa (eye worm) hypothetical protein 0.0094 0.0126 0.0492
Brugia malayi intermediate filament protein 0.0028 0.0021 0.0081
Plasmodium falciparum serine repeat antigen 2 0.0149 0.0215 0.2205
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0274 0.107
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0149 0.0215 0.2205
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0213 0.0317 0.2104
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0073 0.0767
Onchocerca volvulus Matrilysin homolog 0.0048 0.0054 0.0439
Leishmania major hypothetical protein, conserved 0.0096 0.013 0.0829
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0149 0.0215 0.084
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0077
Trypanosoma brucei Calpain-like protein CALP1.3 0.0509 0.0791 0.5336
Schistosoma mansoni intermediate filament proteins 0.0028 0.0021 0.0021
Schistosoma mansoni calpain-7 (C02 family) 0.0666 0.1043 0.1043
Trypanosoma brucei unspecified product 0.0213 0.0317 0.2104
Leishmania major protein kinase, putative 0.0094 0.0126 0.0804
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0073 0.0284
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Onchocerca volvulus 0.0027 0.002 0.0161
Mycobacterium tuberculosis Conserved protein 0.0037 0.0036 0.0764
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0011 0.0114
Entamoeba histolytica calpain large subunit domain III containing protein 0.037 0.0569 0.5961
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0172 0.0672
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0656 0.1027 0.3995
Plasmodium falciparum serine repeat antigen 1 0.0149 0.0215 0.2205
Brugia malayi MH2 domain containing protein 0.0122 0.0172 0.0672
Trichomonas vaginalis calpain, putative 0.0296 0.045 0.4697
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0012 0.0045
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0565 0.0882 0.5957
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0296 0.045 0.4744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.9139
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0149 0.0215 0.206
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0752 0.118 0.7991
Brugia malayi Papain family cysteine protease containing protein 0.0149 0.0215 0.084
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0565 0.0882 0.5957
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.2104
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0623 0.0975 0.3788
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0021 0.001 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0149 0.0215 0.2197
Plasmodium falciparum thioredoxin reductase 0.0034 0.003 0.0242
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0018 0.0171
Trypanosoma cruzi centrin-3 0.0121 0.017 0.0632
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0004 0.0004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0578 0.0902 0.3503
Loa Loa (eye worm) trypsin family protein 0.0021 0.001 0.0038
Brugia malayi Papain family cysteine protease containing protein 0.0149 0.0215 0.084
Onchocerca volvulus 0.0422 0.0652 0.5313
Trichomonas vaginalis calmodulin, putative 0.0027 0.002 0.0123
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0091 0.0357
Echinococcus multilocularis calpain family protein 1, d 0.1076 0.17 0.6643
Echinococcus multilocularis Mastin 0.0021 0.001 0.0038
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0149 0.0215 0.2219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0018 0.0038
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.003 0.0235
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0031 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Plasmodium falciparum serine repeat antigen 8 0.0149 0.0215 0.2205
Plasmodium vivax centrin-1, putative 0.0094 0.0126 0.1207
Brugia malayi Matrixin family protein 0.0022 0.0011 0.0044
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Brugia malayi calpain 5 0.037 0.0569 0.2224
Plasmodium falciparum glutathione reductase 0.0034 0.003 0.0242
Schistosoma mansoni neuronal calcium sensor 0.0094 0.0126 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Brugia malayi calcium-binding protein 0.0094 0.0126 0.0492
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.005 0.0196
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.003 0.0287
Trypanosoma cruzi major cysteine proteinase, putative 0.0149 0.0215 0.0811
Schistosoma mansoni hypothetical protein 0.0094 0.0126 0.0126
Mycobacterium ulcerans beta-lactamase 0.0037 0.0036 0.3321
Onchocerca volvulus 0.0037 0.0036 0.0292
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0936 0.1475 1
Plasmodium falciparum centrin-4 0.0027 0.002 0.0133
Onchocerca volvulus 0.078 0.1226 1
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0053 0.0053
Echinococcus granulosus calpain 7 C02 family 0.0666 0.1043 0.4075
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.1138 0.1799 0.1799
Echinococcus granulosus cathepsin L 0.0149 0.0215 0.084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0044
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0509 0.0791 0.3067
Loa Loa (eye worm) beta-lactamase 0.0037 0.0036 0.014
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.154 0.2443 0.2442
Leishmania major calpain protease-like protein 0.0296 0.045 0.3014
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0296 0.045 0.3014
Brugia malayi Hemopexin family protein 0.0031 0.0026 0.0101
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Entamoeba histolytica cysteine proteinase, putative 0.0607 0.0949 1
Leishmania major small myristoylated protein-1 0.0367 0.0564 0.3788
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0149 0.0215 0.2197
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Trypanosoma cruzi cysteine peptidase, putative 0.0335 0.0513 0.1977
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.086 0.1354 0.5276
Echinococcus granulosus EF hand domain containing family member A2 0.0096 0.013 0.0507
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0036 0.3321
Trichomonas vaginalis calmodulin, putative 0.0121 0.017 0.1715
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Trypanosoma brucei small myristoylated protein 1-2 0.0367 0.0564 0.3788
Schistosoma mansoni Mername-AA248 (C02 family) 0.0666 0.1043 0.1043
Echinococcus granulosus EF hand domain containing family member A2 0.0094 0.0126 0.0492
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0172 0.0672
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0036 0.0764
Brugia malayi EF hand family protein 0.0094 0.0126 0.0492
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0036 0.0188
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0094 0.0126 0.0492
Entamoeba histolytica cysteine proteinase, putative 0.0607 0.0949 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Brugia malayi Pre-SET motif family protein 0.0419 0.0648 0.2532
Loa Loa (eye worm) hypothetical protein 0.078 0.1226 0.4791
Schistosoma mansoni calpain-2 (C02 family) 0.0296 0.045 0.045
Schistosoma mansoni calmodulin related calcium binding protein 0.0094 0.0126 0.0126
Echinococcus granulosus calcyphosin protein 0.0027 0.002 0.0077
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0509 0.0791 0.3067
Onchocerca volvulus 0.0149 0.0215 0.1753
Leishmania major cathepsin L-like protease 0.08 0.1258 0.8525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Mycobacterium ulcerans hydrolase 0.0027 0.0019 0.129
Leishmania major cytochrome p450-like protein 0.0027 0.002 0.008
Leishmania major calpain family cysteine protease-like protein 0.0509 0.0791 0.5336
Schistosoma mansoni calpain-7 (C02 family) 0.0666 0.1043 0.1043
Echinococcus multilocularis cysteine protease 0.0607 0.0949 0.3709
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Echinococcus multilocularis calpain 5 0.0666 0.1043 0.4075
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0812 0.1277 0.8654
Schistosoma mansoni cathepsin C 0.0149 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.1613 0.2559 1
Schistosoma mansoni hypothetical protein 0.013 0.0184 0.0184
Brugia malayi Papain family cysteine protease containing protein 0.0149 0.0215 0.084
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0936 0.1475 0.5748
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0094 0.0126 0.0126
Onchocerca volvulus 0.0607 0.0949 0.7741
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0094 0.0126 0.0462
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Loa Loa (eye worm) RecQ helicase 0.0022 0.0012 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0036 0.0036
Trypanosoma cruzi kinesin, putative 0.037 0.0569 0.2199
Loa Loa (eye worm) hypothetical protein 0.1447 0.2293 0.8959
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.0184 0.072
Echinococcus granulosus cathepsin l1 0.0422 0.0652 0.2546
Leishmania major trypanothione reductase 0.0097 0.0132 0.084
Echinococcus granulosus calbindin 32 0.0096 0.013 0.0507
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Echinococcus granulosus cathepsin L cysteine protease 0.0335 0.0513 0.2003
Echinococcus multilocularis glycoprotein Antigen 5 0.0021 0.001 0.0038
Entamoeba histolytica cysteine protease, putative 0.0607 0.0949 1
Echinococcus granulosus enteropeptidase 0.0021 0.001 0.0038
Loa Loa (eye worm) hypothetical protein 0.0607 0.0949 0.3709
Echinococcus granulosus calmodulin 0.0094 0.0126 0.0492
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0096 0.013 0.013
Brugia malayi calpain 7 0.0666 0.1043 0.4075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Brugia malayi Matrixin family protein 0.0022 0.0011 0.0044
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0509 0.0791 0.5336
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0602 0.094 0.3653
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0149 0.0215 0.206
Trichomonas vaginalis calcium binding proteins, putative 0.0094 0.0126 0.1253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.0513 0.344
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0018 0.0067
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0638 0.0998 0.675
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Onchocerca volvulus 0.0021 0.001 0.008
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0149 0.0215 0.2197
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0021 0.001 0.001
Echinococcus multilocularis calumenin 0.0096 0.013 0.0507
Echinococcus granulosus calumenin 0.0096 0.013 0.0507
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0269 0.0408 0.2725
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.003 0.0287
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.2104
Mycobacterium leprae Probable lipase LipE 0.0037 0.0036 0.0481
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.5136
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0656 0.1027 0.695
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.0652 0.6837
Echinococcus granulosus bloom syndrome protein 0.0022 0.0012 0.0045
Trypanosoma cruzi centrin, putative 0.0121 0.017 0.0632
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0011 0.0036
Trichomonas vaginalis calcium binding protein, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi kinesin, putative 0.037 0.0569 0.2199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0041
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Echinococcus multilocularis lamin 0.0028 0.0021 0.0081
Onchocerca volvulus Cathepsin L homolog 0.0607 0.0949 0.7741
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0936 0.1475 1
Brugia malayi Trypsin family protein 0.0021 0.001 0.0038
Echinococcus multilocularis cathepsin L 0.0335 0.0513 0.2003
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0561 0.0874 0.3396
Trypanosoma brucei calpain-like protein, putative 0.0666 0.1043 0.7057
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0094 0.0126 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0008 0.0032
Echinococcus granulosus glycoprotein Antigen 5 0.0021 0.001 0.0038
Leishmania major hypothetical protein, conserved 0.0021 0.0011 0.0017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0069 0.027
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0509 0.0791 0.3067
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0335 0.0513 0.0513
Trichomonas vaginalis calpain, putative 0.0296 0.045 0.4697
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0021 0.001 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0011 0.001
Onchocerca volvulus 0.0607 0.0949 0.7741
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.0513 0.5361
Trypanosoma brucei calpain, putative 0.0565 0.0882 0.5957
Plasmodium falciparum serine repeat antigen 6 0.0149 0.0215 0.2205
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0073 0.0284
Trichomonas vaginalis caltractin, putative 0.0027 0.002 0.0123
Onchocerca volvulus 0.0021 0.0011 0.0086
Onchocerca volvulus Matrilysin homolog 0.0022 0.0011 0.0092
Echinococcus multilocularis dna polymerase kappa 0.002 0.0008 0.0032
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0021 0.0081
Loa Loa (eye worm) hypothetical protein 0.0186 0.0274 0.107
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.003 0.0149
Brugia malayi Cytochrome P450 family protein 0.0027 0.002 0.0078
Schistosoma mansoni calpain (C02 family) 0.0666 0.1043 0.1043
Leishmania major calcineurin B subunit, putative 0.0094 0.0126 0.0804
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0666 0.1043 0.4057
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0149
Treponema pallidum NADH oxidase 0.0034 0.003 0.5
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0027 0.0019 0.0074
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0094 0.0126 0.1253
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0 0.00000002115
Onchocerca volvulus 0.0607 0.0949 0.7741
Echinococcus multilocularis programmed cell death protein 6 0.0029 0.0024 0.0092
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.0274 0.1042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0149 0.0215 0.084
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0149 0.0215 0.084
Onchocerca volvulus 0.0021 0.001 0.008
Trypanosoma cruzi caltractin, putative 0.0094 0.0126 0.0462
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0018 0.0113
Toxoplasma gondii cathepsin CPC2 0.0149 0.0215 0.2266
Giardia lamblia Programmed cell death protein-like protein 0.0027 0.002 0.0124
Trypanosoma brucei cysteine peptidase, putative 0.0509 0.0791 0.5336
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0311 0.0474 0.1825
Plasmodium vivax calpain, putative 0.0666 0.1043 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0042 0.0355
Toxoplasma gondii calcium binding protein precursor, putative 0.0027 0.002 0.021
Echinococcus granulosus programmed cell death protein 0.0121 0.017 0.0662
Onchocerca volvulus Cathepsin F homolog 0.0607 0.0949 0.7741
Echinococcus multilocularis cysteine protease 0.0607 0.0949 0.3709
Brugia malayi calpain 5 0.0296 0.045 0.1759
Brugia malayi cathepsin L-like precursor 0.0422 0.0652 0.2546
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0091 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0296 0.045 0.3014
Giardia lamblia Cysteine protease 0.0149 0.0215 0.2219
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0509 0.0791 0.3067
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0012 0.0036
Schistosoma mansoni hypothetical protein 0.0296 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.1151 0.1819 0.7107
Schistosoma mansoni centrin 0.0094 0.0126 0.0126
Brugia malayi Probable myosin regulatory light chain 0.0029 0.0024 0.0092
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.005 0.0287
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.002 0.0078
Echinococcus multilocularis cathepsin b 0.1613 0.2559 1
Trypanosoma cruzi cysteine protease, putative 0.0335 0.0513 0.1977
Echinococcus multilocularis calmodulin 0.0094 0.0126 0.0492
Echinococcus multilocularis calcium uptake protein 1 0.0096 0.013 0.0507
Trypanosoma cruzi cysteine peptidase, putative 0.08 0.1258 0.49
Trypanosoma brucei calmodulin, putative 0.0096 0.013 0.0829
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.2104
Trypanosoma brucei mitochondrial calcium uptake 1 0.0094 0.0126 0.0804
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.1209
Echinococcus multilocularis programmed cell death protein 0.0121 0.017 0.0662
Brugia malayi Cathepsin L-like precursor 0.0186 0.0274 0.107
Loa Loa (eye worm) hypothetical protein 0.006 0.0073 0.0284
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0053 0.0053
Toxoplasma gondii centrin 0.0094 0.0126 0.1329
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0936 0.1475 0.5748
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0036 0.3321
Leishmania major calmodulin-like protein 0.0094 0.0126 0.0804
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0269 0.0408 0.2725
Giardia lamblia Hypothetical protein 0.0096 0.013 0.1305
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0149 0.0215 0.206
Schistosoma mansoni neuronal calcium sensor 0.0094 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0246 0.037 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0149 0.0215 0.206
Trichomonas vaginalis calcium binding protein, putative 0.0027 0.002 0.0123
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0149 0.0215 0.2219
Trypanosoma brucei small myristoylated protein 1-1 0.0367 0.0564 0.3788
Echinococcus multilocularis enteropeptidase 0.0021 0.001 0.0038
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0831 0.1307 0.5105
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0036 0.0293
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0335 0.0513 0.0513
Plasmodium falciparum serine repeat antigen 9 0.0149 0.0215 0.2205
Echinococcus granulosus Mastin 0.0021 0.001 0.0038
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Echinococcus granulosus calcium uptake protein 1 0.0096 0.013 0.0507
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0036 0.0764
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0607 0.0949 1
Brugia malayi Trypsin family protein 0.0021 0.001 0.0038
Echinococcus granulosus EF HAND 1 calcium binding site 0.0094 0.0126 0.0492
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0027 0.0019 0.0297
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0098 0.0383
Entamoeba histolytica protein kinase, putative 0.037 0.0569 0.5961
Brugia malayi cathepsin L-like cysteine proteinase 0.0149 0.0215 0.084
Leishmania major hypothetical protein, conserved 0.0518 0.0805 0.5436
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0036 0.014
Onchocerca volvulus 0.006 0.0073 0.0592
Loa Loa (eye worm) EF hand family protein 0.0094 0.0126 0.0492
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0144
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.0357 0.9636
Entamoeba histolytica cysteine proteinase 2 0.0335 0.0513 0.5361
Onchocerca volvulus 0.0022 0.0011 0.0092
Trypanosoma brucei hypothetical protein, conserved 0.0094 0.0126 0.0804
Plasmodium falciparum serine repeat antigen 3 0.0149 0.0215 0.2205
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Echinococcus granulosus geminin 0.0375 0.0577 0.2256
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Leishmania major phospholipase c-like protein 0.0094 0.0126 0.0804
Leishmania major centrin, putative 0.0094 0.0126 0.0804
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0215 0.2197
Loa Loa (eye worm) hypothetical protein 0.0327 0.0501 0.1956
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Schistosoma mansoni hypothetical protein 0.0094 0.0126 0.0126
Giardia lamblia Hypothetical protein 0.0149 0.0215 0.2219
Giardia lamblia Cathepsin B precursor 0.0602 0.094 1
Onchocerca volvulus 0.0037 0.0036 0.0292
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0311 0.0474 0.1825
Trypanosoma cruzi calmodulin, putative 0.0094 0.0126 0.0462
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0096 0.013 0.0477
Echinococcus granulosus Ankyrin 0.0015 0 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0091 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0126 0.0491
Schistosoma mansoni ankyrin 23/unc44 0.0015 0 0.0000000054125
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0126 0.0491
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0046 0.018
Trichomonas vaginalis calpain, putative 0.0296 0.045 0.4697
Trypanosoma brucei centrin, putative 0.0094 0.0126 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0344 0.0528 0.2037
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0132 0.1259
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0094 0.0126 0.1207
Echinococcus granulosus cathepsin L 0.0335 0.0513 0.2003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0221 0.033 0.8908
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Trichomonas vaginalis centrin, putative 0.0094 0.0126 0.1253
Loa Loa (eye worm) hypothetical protein 0.1076 0.17 0.6643
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0857 0.1348 0.5253
Echinococcus multilocularis hypothetical protein 0.0666 0.1043 0.4075
Onchocerca volvulus 0.0096 0.013 0.1058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.0513 0.2003
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0149 0.0215 0.084
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0221 0.033 0.8908
Leishmania major hypothetical protein, conserved 0.0037 0.0036 0.0188
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.0513 0.5361
Entamoeba histolytica hypothetical protein 0.0149 0.0215 0.2197
Giardia lamblia Calmodulin 0.0027 0.002 0.0124
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0098 0.0383
Plasmodium falciparum cysteine proteinase falcipain 3 0.0607 0.0949 1
Loa Loa (eye worm) calpain family protein 1 0.1447 0.2293 0.8959
Echinococcus multilocularis Myosin regulatory light chain 0.0027 0.002 0.0077
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0028 0.03
Brugia malayi beta-lactamase 0.0037 0.0036 0.014
Onchocerca volvulus 0.0607 0.0949 0.7741
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0509 0.0791 0.3067
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0615 0.0961 0.3733
Echinococcus granulosus cysteine protease 0.0335 0.0513 0.2003
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Onchocerca volvulus 0.0031 0.0026 0.0211
Brugia malayi Matrixin family protein 0.0022 0.0011 0.0044
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0607 0.0949 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0215 0.2197
Loa Loa (eye worm) calpain 5 0.037 0.0569 0.2224
Echinococcus multilocularis calmodulin 0.0094 0.0126 0.0492
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0091 0.0567
Toxoplasma gondii ABC1 family protein 0.0037 0.0036 0.0379
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0269 0.0408 0.2725
Brugia malayi Matrixin family protein 0.0022 0.0011 0.0044
Trichomonas vaginalis calcineurin B subunit, putative 0.0096 0.013 0.1292
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.0513 0.2003
Echinococcus granulosus cathepsin b 0.1613 0.2559 1
Schistosoma mansoni cathepsin F (C01 family) 0.0422 0.0652 0.0651
Echinococcus granulosus cathepsin L cysteine proteinase 0.0607 0.0949 0.3709
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.003 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0213 0.0317 0.1209
Leishmania major cathepsin L-like protease 0.08 0.1258 0.8525
Brugia malayi programmed cell death protein 6 0.0094 0.0126 0.0492
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.003 0.0117
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Echinococcus granulosus neurocalcin 0.0094 0.0126 0.0492
Onchocerca volvulus Cathepsin L homolog 0.0607 0.0949 0.7741
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0073 0.0073
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0607 0.0949 0.3709
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0602 0.094 0.094
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Toxoplasma gondii EFHC1, putative 0.0094 0.0126 0.1329
Loa Loa (eye worm) CYP4Cod1 0.0027 0.002 0.0078
Trichomonas vaginalis hypothetical protein 0.0296 0.045 0.4697
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.0513 0.344
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0078
Leishmania major DNA polymerase eta, putative 0.0046 0.005 0.0287
Leishmania major programmed cell death 6 protein-like protein 0.0094 0.0126 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0036 0.0108
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0132 0.3409
Loa Loa (eye worm) matrix metalloproteinase 0.0022 0.0011 0.0044
Brugia malayi Neuronal calcium sensor family protein 1 0.0027 0.002 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0126 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.0317 0.1209
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0812 0.1277 0.8654
Plasmodium falciparum serine repeat antigen 5 0.0149 0.0215 0.2205
Echinococcus multilocularis geminin 0.0375 0.0577 0.2256
Brugia malayi Pre-SET motif family protein 0.006 0.0073 0.0284
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.003 0.0149
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0021 0.001 0.0038
Toxoplasma gondii EF hand domain-containing protein 0.0094 0.0126 0.1329
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.0038
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Loa Loa (eye worm) hypothetical protein 0.0422 0.0652 0.2546
Trypanosoma cruzi unspecified product 0.0367 0.0564 0.2177
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1613 0.2559 0.2559
Plasmodium vivax unspecified product 0.0186 0.0274 0.2625
Brugia malayi Calmodulin-like protein 0.0094 0.0126 0.0492
Echinococcus granulosus centrin 2 0.0094 0.0126 0.0492
Toxoplasma gondii hypothetical protein 0.0296 0.045 0.4744
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.045 0.4697
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0607 0.0949 1
Echinococcus multilocularis dna polymerase eta 0.0046 0.005 0.0196
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.003 0.0086
Giardia lamblia Cysteine protease 0.0149 0.0215 0.2219
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0149 0.0215 0.084
Brugia malayi EF hand family protein 0.0096 0.013 0.0507
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0509 0.0791 0.3067
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.003 0.0149
Trypanosoma brucei Calpain-like protein 1.1 0.0857 0.1348 0.9139
Giardia lamblia Cathepsin B precursor 0.0602 0.094 1
Loa Loa (eye worm) matrixin family protein 0.0053 0.0061 0.0238
Schistosoma mansoni centrin-related 0.0094 0.0126 0.0126
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0656 0.1027 0.3995
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0027 0.002 0.0123
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0335 0.0513 0.1977
Plasmodium falciparum centrin-1 0.0094 0.0126 0.1261
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.2952
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Onchocerca volvulus Cathepsin L homolog 0.0149 0.0215 0.1753
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0077
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0094 0.0126 0.0462
Echinococcus multilocularis cathepsin L 0.0149 0.0215 0.084
Brugia malayi cathepsin B-like cysteine proteinase 0.1613 0.2559 1
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Trypanosoma cruzi I/6 autoantigen, putative 0.0094 0.0126 0.0462
Onchocerca volvulus 0.0021 0.001 0.008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0607 0.0949 0.3709
Trichomonas vaginalis calcium binding protein, putative 0.0094 0.0126 0.1253
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0149 0.0215 0.206
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.0648 0.2532
Toxoplasma gondii calcium-dependent protein kinase 0.0096 0.013 0.1369
Toxoplasma gondii calmodulin CAM2 0.0027 0.002 0.021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Trichomonas vaginalis centrin, putative 0.0094 0.0126 0.1253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Loa Loa (eye worm) hypothetical protein 0.0296 0.045 0.1759
Echinococcus multilocularis lamin dm0 0.0028 0.0021 0.0081
Brugia malayi calpain family protein 1 0.1447 0.2293 0.8959
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0094 0.0126 0.0492
Trypanosoma brucei Component of motile flagella 41 0.0094 0.0126 0.0804
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0126 0.1253
Plasmodium vivax vivapain-2 0.0607 0.0949 0.91
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.003 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0215 0.2197
Loa Loa (eye worm) calpain D 0.0296 0.045 0.1759
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0018 0.0191
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.003 0.2629
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.003 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0149 0.0215 0.2197
Toxoplasma gondii cathepsin B 0.0602 0.094 0.9903
Entamoeba histolytica calcium binding family protein 0.0094 0.0126 0.1253
Mycobacterium tuberculosis Conserved protein 0.0037 0.0036 0.0764
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0036 0.0764
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0012 0.0036
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0246 0.037 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0046 0.018
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0149 0.0215 0.206
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0215 0.2197
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0149 0.0215 0.0215
Plasmodium vivax hypothetical protein, conserved 0.0096 0.013 0.1243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0221 0.033 0.8908
Leishmania major hypothetical protein, conserved 0.0344 0.0528 0.3544
Schistosoma mansoni cathepsin S (C01 family) 0.0149 0.0215 0.0215
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0213 0.0317 0.2104
Echinococcus multilocularis transmembrane protease serine 3 0.0021 0.001 0.0038
Brugia malayi hypothetical protein 0.0017 0.0003 0.0012
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0094 0.0126 0.0804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Mycobacterium ulcerans hypothetical protein 0.0021 0.001 0.0205
Loa Loa (eye worm) calpain family protein 1 0.1076 0.17 0.6643
Brugia malayi hypothetical protein 0.0026 0.0018 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Trypanosoma cruzi cruzipain precursor, putative 0.0186 0.0274 0.1042
Echinococcus granulosus lamin dm0 0.0028 0.0021 0.0081
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0042 0.0355
Trypanosoma brucei centrin-3 0.0121 0.017 0.11
Leishmania major hypothetical protein, unknown function 0.0296 0.045 0.3014
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0036 0.0108
Schistosoma mansoni neuronal calcium sensor 0.0094 0.0126 0.0126
Entamoeba histolytica calmodulin, putative 0.0094 0.0126 0.1253
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1613 0.2559 0.2559
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0036 0.0764
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0213 0.0317 0.2104
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0335 0.0513 0.0513
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0149 0.0215 0.2219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.0513 0.5361
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.003 0.2629
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0132 0.0513
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0094 0.0126 0.1253
Trichomonas vaginalis myosin light chain 1, putative 0.0094 0.0126 0.1253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.0513 0.5361
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0036 0.0764
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0017
Schistosoma mansoni mitochondrial solute carrier 0.0094 0.0126 0.0126
Entamoeba histolytica calmodulin, putative 0.0027 0.002 0.0123
Trichomonas vaginalis centrin, putative 0.0027 0.002 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.007
Toxoplasma gondii calmodulin, putative 0.0027 0.002 0.021
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Trichomonas vaginalis kakapo, putative 0.0027 0.002 0.0123
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0936 0.1475 0.5748
Brugia malayi Uncoordinated protein 44 0.0015 0 0.00000002115
Schistosoma mansoni cathepsin s 0.0186 0.0274 0.0274
Trichomonas vaginalis centrin, putative 0.0027 0.002 0.0123
Brugia malayi Papain family cysteine protease containing protein 0.0607 0.0949 0.3709
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0509 0.0791 0.5336
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0149 0.0215 0.2205
Schistosoma mansoni calmodulin-related 0.0027 0.002 0.002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0091 0.23
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.003 0.0318
Trypanosoma cruzi conserved protein 0.0518 0.0805 0.3124
Trypanosoma brucei cytochrome P450, putative 0.0027 0.002 0.008
Schistosoma mansoni cathepsin F (C01 family) 0.0607 0.0949 0.0949
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.0317 0.1209
Mycobacterium tuberculosis Probable oxidoreductase 0.0246 0.037 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0008 0.0008
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.5136
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0602 0.094 0.9903
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0126 0.0491
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Entamoeba histolytica cysteine proteinase 1, putative 0.0335 0.0513 0.5361
Loa Loa (eye worm) myosin regulatory light chain 1 0.0027 0.002 0.0077
Onchocerca volvulus 0.0028 0.0021 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0126 0.0491
Schistosoma mansoni hypothetical protein 0.0021 0.001 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0509 0.0791 0.5336
Echinococcus multilocularis EF hand domain containing family member A2 0.0094 0.0126 0.0492
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.002 0.0046
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1447 0.2293 0.2293
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.086 0.1354 0.5276
Plasmodium vivax vivapain-1 0.0335 0.0513 0.4914
Onchocerca volvulus 0.0607 0.0949 0.7741
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0126 0.0126
Leishmania major DNA polymerase eta, putative 0.0032 0.0028 0.0137
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0091 0.0091
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1613 0.2559 0.2559
Loa Loa (eye worm) programmed cell death protein 6 0.0096 0.013 0.0507
Brugia malayi glutathione reductase 0.0097 0.0132 0.0513
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0149 0.0215 0.206
Brugia malayi calpain D 0.0296 0.045 0.1759
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0028 0.0079
Plasmodium falciparum calpain 0.0296 0.045 0.4703
Echinococcus granulosus neuronal calcium sensor 0.0094 0.0126 0.0492
Echinococcus granulosus calpain A 0.0666 0.1043 0.4075
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0126 0.1253
Trypanosoma brucei cysteine peptidase C (CPC) 0.0602 0.094 0.6355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0311 0.0474 0.1825
Brugia malayi beta-lactamase family protein 0.0037 0.0036 0.014
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0149 0.0215 0.0215
Loa Loa (eye worm) ctsf protein 0.0607 0.0949 0.3709
Trichomonas vaginalis caltractin, putative 0.0027 0.002 0.0123
Schistosoma mansoni calpain C (C02 family) 0.0666 0.1043 0.1043
Mycobacterium ulcerans lipase LipD 0.0037 0.0036 0.3321
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.002 0.1412
Schistosoma mansoni calmodulin 0.0094 0.0126 0.0126
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0509 0.0791 0.3067
Echinococcus granulosus calpain A 0.1542 0.2446 0.9559
Echinococcus granulosus calpain 5 0.0666 0.1043 0.4075
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.003 0.0242
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0812 0.1277 0.8654
Trypanosoma brucei calpain-like protein, putative 0.0666 0.1043 0.7057
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.003 0.5
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0091 0.0964
Loa Loa (eye worm) hypothetical protein 0.0186 0.0274 0.107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0073 0.0073
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0021 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0036 0.0342
Loa Loa (eye worm) hypothetical protein 0.0094 0.0126 0.0492
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0008 0.0032
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0425 0.0658 0.2546
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0036 0.014
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.154 0.2443 0.9544
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.1209
Plasmodium vivax vivapain-2 0.0607 0.0949 0.91
Schistosoma mansoni thyroid hormone receptor 0.014 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Echinococcus granulosus programmed cell death protein 6 0.0029 0.0024 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0215 0.2197
Trypanosoma brucei Calpain-like protein 2 0.0638 0.0998 0.675
Trichomonas vaginalis conserved hypothetical protein 0.0344 0.0528 0.5523
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0149 0.0215 0.0215
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.0184 0.072
Trypanosoma cruzi centrin, putative 0.0121 0.017 0.0632
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.005 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0094 0.0126 0.0804
Echinococcus granulosus dna polymerase eta 0.0046 0.005 0.0196
Echinococcus multilocularis cathepsin b 0.1613 0.2559 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0149 0.0215 0.2197
Trichomonas vaginalis calcium binding protein, putative 0.0121 0.017 0.1715
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Schistosoma mansoni hypothetical protein 0.0375 0.0577 0.0577
Schistosoma mansoni lamin 0.0028 0.0021 0.0021
Echinococcus granulosus lamin 0.0028 0.0021 0.0081
Onchocerca volvulus 0.0028 0.0021 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0311 0.0474 0.3175
Trypanosoma brucei Calpain-like protein 1.2 0.0656 0.1027 0.695
Brugia malayi Matrixin family protein 0.0053 0.0061 0.0238
Brugia malayi Thioredoxin reductase 0.0097 0.0132 0.0513
Leishmania major small myristoylated protein-2 0.0668 0.1047 0.7081
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.154 0.2443 0.9544
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0016 0.0061
Brugia malayi Cathepsin L-like precursor 0.0422 0.0652 0.2546
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0036 0.0293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0054 0.0439
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.002 0.0078
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Trypanosoma brucei I/6 autoantigen 0.0094 0.0126 0.0804
Entamoeba histolytica calpain family cysteine protease, putative 0.0296 0.045 0.4697
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0509 0.0791 0.3067
Echinococcus multilocularis calpain 0.0666 0.1043 0.4075
Brugia malayi Trypsin family protein 0.0021 0.001 0.0038
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0149 0.0215 0.206
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Echinococcus multilocularis calbindin 32 0.0096 0.013 0.0507
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Schistosoma mansoni hypothetical protein 0.0375 0.0577 0.0577
Mycobacterium tuberculosis Probable reductase 0.0221 0.033 0.8908
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0666 0.1043 0.4057
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0046 0.018
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.9139
Toxoplasma gondii thioredoxin reductase 0.0097 0.0132 0.1386
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0079 0.0104 0.0404
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0666 0.1043 0.7057
Echinococcus granulosus transmembrane protease serine 3 0.0021 0.001 0.0038
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0022 0.0011 0.0011
Onchocerca volvulus 0.0094 0.0126 0.1028
Echinococcus multilocularis cathepsin L cysteine protease 0.0607 0.0949 0.3709
Schistosoma mansoni hypothetical protein 0.0021 0.001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0091 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0221 0.033 0.8908
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Onchocerca volvulus 0.0021 0.001 0.008
Leishmania major hypothetical protein, conserved 0.0094 0.0126 0.0804
Schistosoma mansoni myosin regulatory light chain 0.0027 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Trypanosoma brucei caltractin, putative 0.0121 0.017 0.11
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Brugia malayi Protein kinase domain containing protein 0.0015 0 0.00000002115
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.9139
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Trypanosoma cruzi cruzipain precursor, putative 0.08 0.1258 0.49
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Onchocerca volvulus 0.0094 0.0126 0.1028
Trypanosoma brucei protein I/6 0.0094 0.0126 0.0804
Echinococcus granulosus Myosin regulatory light chain 0.0027 0.002 0.0077
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0149
Schistosoma mansoni reticulocalbin 0.0094 0.0126 0.0126
Toxoplasma gondii troponin c, isotype gamma, putative 0.0094 0.0126 0.1329
Leishmania major centrin, putative 0.0094 0.0126 0.0804
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Plasmodium vivax unspecified product 0.0335 0.0513 0.4914
Trichomonas vaginalis esterase, putative 0.0037 0.0036 0.0293
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0607 0.0949 0.3709
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0046 0.018
Schistosoma mansoni cathepsin F (C01 family) 0.0607 0.0949 0.0949
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Onchocerca volvulus 0.0021 0.001 0.008
Echinococcus multilocularis EF hand domain containing family member A2 0.0096 0.013 0.0507
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0149 0.0215 0.2197
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0077
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.003 0.0605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Loa Loa (eye worm) cathepsin B 0.0602 0.094 0.3673
Giardia lamblia Cysteine protease 0.0149 0.0215 0.2219
Echinococcus multilocularis calcyphosin protein 0.0027 0.002 0.0077
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.0274 0.107
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.002 0.0123
Plasmodium vivax serine-repeat antigen (SERA) 0.0149 0.0215 0.206
Entamoeba histolytica grainin 2 0.0121 0.017 0.1715
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0132 0.0483

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 90 uM Inhibition of Plasmodium falciparum recombinant SAHH ChEMBL. 18374570
IC50 (binding) = 163 uM Inhibition of human recombinant SAHH ChEMBL. 18374570
IC50 (binding) = 163 uM Inhibition of human recombinant SAHH ChEMBL. 18374570
Ratio IC50 (binding) = 0.55 Selectivity ratio of human recombinant SAHH to Plasmodium falciparum recombinant SAHH ChEMBL. 18374570

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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