Detailed information for compound 513282

Basic information

Technical information
  • TDR Targets ID: 513282
  • Name: (1R,2S,3R,5S)-3-(6-aminopurin-9-yl)-5-azidocy clopentane-1,2-diol
  • MW: 276.255 | Formula: C10H12N8O2
  • H donors: 3 H acceptors: 5 LogP: -0.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [N-]=[N+]=N[C@H]1C[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N
  • InChi: 1S/C10H12N8O2/c11-9-6-10(14-2-13-9)18(3-15-6)5-1-4(16-17-12)7(19)8(5)20/h2-5,7-8,19-20H,1H2,(H2,11,13,14)/t4-,5+,7+,8-/m0/s1
  • InChiKey: UPIWCZFYODCBAS-LAHCRNKXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1R,2S,3R,5S)-3-(6-aminopurin-9-yl)-5-azido-cyclopentane-1,2-diol
  • (1R,2S,3R,5S)-3-adenin-9-yl-5-azido-cyclopentane-1,2-diol
  • (1R,2S,3R,5S)-3-(6-amino-9-purinyl)-5-azidocyclopentane-1,2-diol
  • (-)-1,2-Cyclopentanediol, 3-(6-amino-9H-purin-9-yl)-5-azido-, (1R,2S,3R,5S)-
  • AIDS-114106
  • AIDS114106

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0053 0.0053
Leishmania major calmodulin-like protein 0.0094 0.0126 0.0804
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0036 0.3321
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0936 0.1475 0.5748
Toxoplasma gondii centrin 0.0094 0.0126 0.1329
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Schistosoma mansoni neuronal calcium sensor 0.0094 0.0126 0.0126
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0149 0.0215 0.206
Giardia lamblia Hypothetical protein 0.0096 0.013 0.1305
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0269 0.0408 0.2725
Trichomonas vaginalis calcium binding protein, putative 0.0027 0.002 0.0123
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0246 0.037 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0149 0.0215 0.206
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Plasmodium falciparum serine repeat antigen 9 0.0149 0.0215 0.2205
Echinococcus granulosus Mastin 0.0021 0.001 0.0038
Echinococcus multilocularis enteropeptidase 0.0021 0.001 0.0038
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0335 0.0513 0.0513
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0831 0.1307 0.5105
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0036 0.0293
Trypanosoma brucei small myristoylated protein 1-1 0.0367 0.0564 0.3788
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0149 0.0215 0.2219
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0098 0.0383
Echinococcus granulosus EF HAND 1 calcium binding site 0.0094 0.0126 0.0492
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0027 0.0019 0.0297
Brugia malayi Trypsin family protein 0.0021 0.001 0.0038
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0607 0.0949 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0036 0.0764
Echinococcus granulosus calcium uptake protein 1 0.0096 0.013 0.0507
Onchocerca volvulus 0.006 0.0073 0.0592
Leishmania major hypothetical protein, conserved 0.0518 0.0805 0.5436
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0036 0.014
Brugia malayi cathepsin L-like cysteine proteinase 0.0149 0.0215 0.084
Entamoeba histolytica protein kinase, putative 0.037 0.0569 0.5961
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0144
Loa Loa (eye worm) EF hand family protein 0.0094 0.0126 0.0492
Onchocerca volvulus Cathepsin F homolog 0.0607 0.0949 0.7741
Echinococcus granulosus programmed cell death protein 0.0121 0.017 0.0662
Toxoplasma gondii calcium binding protein precursor, putative 0.0027 0.002 0.021
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0042 0.0355
Brugia malayi calpain 5 0.0296 0.045 0.1759
Echinococcus multilocularis cysteine protease 0.0607 0.0949 0.3709
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0091 1
Brugia malayi cathepsin L-like precursor 0.0422 0.0652 0.2546
Giardia lamblia Cysteine protease 0.0149 0.0215 0.2219
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0296 0.045 0.3014
Schistosoma mansoni hypothetical protein 0.0296 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.1151 0.1819 0.7107
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0012 0.0036
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0509 0.0791 0.3067
Trypanosoma cruzi cysteine protease, putative 0.0335 0.0513 0.1977
Echinococcus multilocularis cathepsin b 0.1613 0.2559 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.002 0.0078
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.005 0.0287
Schistosoma mansoni centrin 0.0094 0.0126 0.0126
Brugia malayi Probable myosin regulatory light chain 0.0029 0.0024 0.0092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0029
Trypanosoma brucei calmodulin, putative 0.0096 0.013 0.0829
Trypanosoma brucei mitochondrial calcium uptake 1 0.0094 0.0126 0.0804
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.2104
Trypanosoma cruzi cysteine peptidase, putative 0.08 0.1258 0.49
Echinococcus multilocularis calcium uptake protein 1 0.0096 0.013 0.0507
Echinococcus multilocularis calmodulin 0.0094 0.0126 0.0492
Loa Loa (eye worm) hypothetical protein 0.006 0.0073 0.0284
Brugia malayi Cathepsin L-like precursor 0.0186 0.0274 0.107
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.1209
Echinococcus multilocularis programmed cell death protein 0.0121 0.017 0.0662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Echinococcus granulosus cathepsin L 0.0335 0.0513 0.2003
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0132 0.1259
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0094 0.0126 0.1207
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0221 0.033 0.8908
Onchocerca volvulus 0.0096 0.013 0.1058
Echinococcus multilocularis hypothetical protein 0.0666 0.1043 0.4075
Loa Loa (eye worm) hypothetical protein 0.1076 0.17 0.6643
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0857 0.1348 0.5253
Trichomonas vaginalis centrin, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0149 0.0215 0.084
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.0513 0.2003
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0221 0.033 0.8908
Leishmania major hypothetical protein, conserved 0.0037 0.0036 0.0188
Plasmodium falciparum cysteine proteinase falcipain 3 0.0607 0.0949 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0098 0.0383
Giardia lamblia Calmodulin 0.0027 0.002 0.0124
Entamoeba histolytica hypothetical protein 0.0149 0.0215 0.2197
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.0513 0.5361
Echinococcus granulosus geminin 0.0375 0.0577 0.2256
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Plasmodium falciparum serine repeat antigen 3 0.0149 0.0215 0.2205
Trypanosoma brucei hypothetical protein, conserved 0.0094 0.0126 0.0804
Onchocerca volvulus 0.0022 0.0011 0.0092
Entamoeba histolytica cysteine proteinase 2 0.0335 0.0513 0.5361
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.0357 0.9636
Leishmania major centrin, putative 0.0094 0.0126 0.0804
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Leishmania major phospholipase c-like protein 0.0094 0.0126 0.0804
Loa Loa (eye worm) hypothetical protein 0.0327 0.0501 0.1956
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0215 0.2197
Giardia lamblia Hypothetical protein 0.0149 0.0215 0.2219
Schistosoma mansoni hypothetical protein 0.0094 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0044
Onchocerca volvulus 0.0037 0.0036 0.0292
Giardia lamblia Cathepsin B precursor 0.0602 0.094 1
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi calmodulin, putative 0.0094 0.0126 0.0462
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0311 0.0474 0.1825
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0126 0.0491
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0046 0.018
Schistosoma mansoni ankyrin 23/unc44 0.0015 0 0.0000000054125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0126 0.0491
Echinococcus granulosus Ankyrin 0.0015 0 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0091 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0096 0.013 0.0477
Trypanosoma brucei centrin, putative 0.0094 0.0126 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0344 0.0528 0.2037
Trichomonas vaginalis calpain, putative 0.0296 0.045 0.4697
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.003 0.0242
Echinococcus granulosus cathepsin L cysteine proteinase 0.0607 0.0949 0.3709
Echinococcus granulosus cathepsin b 0.1613 0.2559 1
Schistosoma mansoni cathepsin F (C01 family) 0.0422 0.0652 0.0651
Echinococcus granulosus neurocalcin 0.0094 0.0126 0.0492
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.003 0.0117
Brugia malayi programmed cell death protein 6 0.0094 0.0126 0.0492
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0213 0.0317 0.1209
Leishmania major cathepsin L-like protease 0.08 0.1258 0.8525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Toxoplasma gondii EFHC1, putative 0.0094 0.0126 0.1329
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0607 0.0949 0.3709
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0602 0.094 0.094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0073 0.0073
Onchocerca volvulus Cathepsin L homolog 0.0607 0.0949 0.7741
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0036 0.0108
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0132 0.3409
Leishmania major programmed cell death 6 protein-like protein 0.0094 0.0126 0.0804
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0078
Leishmania major DNA polymerase eta, putative 0.0046 0.005 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.0513 0.344
Trichomonas vaginalis hypothetical protein 0.0296 0.045 0.4697
Loa Loa (eye worm) CYP4Cod1 0.0027 0.002 0.0078
Echinococcus multilocularis geminin 0.0375 0.0577 0.2256
Brugia malayi Pre-SET motif family protein 0.006 0.0073 0.0284
Plasmodium falciparum serine repeat antigen 5 0.0149 0.0215 0.2205
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0812 0.1277 0.8654
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.0317 0.1209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0126 0.0126
Brugia malayi Neuronal calcium sensor family protein 1 0.0027 0.002 0.0077
Loa Loa (eye worm) matrix metalloproteinase 0.0022 0.0011 0.0044
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Trypanosoma cruzi unspecified product 0.0367 0.0564 0.2177
Loa Loa (eye worm) hypothetical protein 0.0422 0.0652 0.2546
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.0038
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0021 0.001 0.0038
Toxoplasma gondii EF hand domain-containing protein 0.0094 0.0126 0.1329
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.003 0.0149
Echinococcus granulosus centrin 2 0.0094 0.0126 0.0492
Toxoplasma gondii hypothetical protein 0.0296 0.045 0.4744
Brugia malayi Calmodulin-like protein 0.0094 0.0126 0.0492
Plasmodium vivax unspecified product 0.0186 0.0274 0.2625
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1613 0.2559 0.2559
Echinococcus multilocularis dna polymerase eta 0.0046 0.005 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0607 0.0949 1
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.045 0.4697
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0028 0.03
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Echinococcus multilocularis Myosin regulatory light chain 0.0027 0.002 0.0077
Loa Loa (eye worm) calpain family protein 1 0.1447 0.2293 0.8959
Onchocerca volvulus 0.0607 0.0949 0.7741
Brugia malayi beta-lactamase 0.0037 0.0036 0.014
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Echinococcus granulosus cysteine protease 0.0335 0.0513 0.2003
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0615 0.0961 0.3733
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0509 0.0791 0.3067
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0607 0.0949 1
Brugia malayi Matrixin family protein 0.0022 0.0011 0.0044
Onchocerca volvulus 0.0031 0.0026 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0215 0.2197
Echinococcus multilocularis calmodulin 0.0094 0.0126 0.0492
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0091 0.0567
Loa Loa (eye worm) calpain 5 0.037 0.0569 0.2224
Trichomonas vaginalis calcineurin B subunit, putative 0.0096 0.013 0.1292
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0269 0.0408 0.2725
Brugia malayi Matrixin family protein 0.0022 0.0011 0.0044
Toxoplasma gondii ABC1 family protein 0.0037 0.0036 0.0379
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.0513 0.2003
Trypanosoma cruzi I/6 autoantigen, putative 0.0094 0.0126 0.0462
Onchocerca volvulus 0.0021 0.001 0.008
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Brugia malayi cathepsin B-like cysteine proteinase 0.1613 0.2559 1
Echinococcus multilocularis cathepsin L 0.0149 0.0215 0.084
Toxoplasma gondii calcium-dependent protein kinase 0.0096 0.013 0.1369
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.0648 0.2532
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0149 0.0215 0.206
Trichomonas vaginalis calcium binding protein, putative 0.0094 0.0126 0.1253
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0607 0.0949 0.3709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Trichomonas vaginalis centrin, putative 0.0094 0.0126 0.1253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Toxoplasma gondii calmodulin CAM2 0.0027 0.002 0.021
Echinococcus multilocularis lamin dm0 0.0028 0.0021 0.0081
Loa Loa (eye worm) hypothetical protein 0.0296 0.045 0.1759
Trypanosoma brucei Component of motile flagella 41 0.0094 0.0126 0.0804
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0094 0.0126 0.0492
Brugia malayi calpain family protein 1 0.1447 0.2293 0.8959
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.003 0.0318
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Plasmodium vivax vivapain-2 0.0607 0.0949 0.91
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0126 0.1253
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.003 0.2629
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0018 0.0191
Loa Loa (eye worm) calpain D 0.0296 0.045 0.1759
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0215 0.2197
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.003 0.0117
Giardia lamblia Cysteine protease 0.0149 0.0215 0.2219
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.003 0.0086
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0509 0.0791 0.3067
Brugia malayi EF hand family protein 0.0096 0.013 0.0507
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0149 0.0215 0.084
Giardia lamblia Cathepsin B precursor 0.0602 0.094 1
Trypanosoma brucei Calpain-like protein 1.1 0.0857 0.1348 0.9139
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.003 0.0149
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0656 0.1027 0.3995
Schistosoma mansoni centrin-related 0.0094 0.0126 0.0126
Loa Loa (eye worm) matrixin family protein 0.0053 0.0061 0.0238
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0027 0.002 0.0123
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.2952
Plasmodium falciparum centrin-1 0.0094 0.0126 0.1261
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0335 0.0513 0.1977
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.0011
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0094 0.0126 0.0462
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0077
Onchocerca volvulus Cathepsin L homolog 0.0149 0.0215 0.1753
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Trypanosoma cruzi cruzipain precursor, putative 0.0186 0.0274 0.1042
Echinococcus granulosus lamin dm0 0.0028 0.0021 0.0081
Trypanosoma brucei centrin-3 0.0121 0.017 0.11
Leishmania major hypothetical protein, unknown function 0.0296 0.045 0.3014
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0042 0.0355
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0213 0.0317 0.2104
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0036 0.0764
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1613 0.2559 0.2559
Entamoeba histolytica calmodulin, putative 0.0094 0.0126 0.1253
Schistosoma mansoni neuronal calcium sensor 0.0094 0.0126 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0036 0.0108
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0132 0.0513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.0513 0.5361
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.003 0.2629
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0149 0.0215 0.2219
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0335 0.0513 0.0513
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0017
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0036 0.0764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.0513 0.5361
Trichomonas vaginalis myosin light chain 1, putative 0.0094 0.0126 0.1253
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0094 0.0126 0.1253
Trichomonas vaginalis centrin, putative 0.0027 0.002 0.0123
Entamoeba histolytica calmodulin, putative 0.0027 0.002 0.0123
Schistosoma mansoni mitochondrial solute carrier 0.0094 0.0126 0.0126
Mycobacterium tuberculosis Conserved protein 0.0037 0.0036 0.0764
Entamoeba histolytica calcium binding family protein 0.0094 0.0126 0.1253
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0149 0.0215 0.2197
Toxoplasma gondii cathepsin B 0.0602 0.094 0.9903
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0246 0.037 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0012 0.0036
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0036 0.0764
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0096 0.013 0.1243
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0149 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0215 0.2197
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0149 0.0215 0.206
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0046 0.018
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0213 0.0317 0.2104
Schistosoma mansoni cathepsin S (C01 family) 0.0149 0.0215 0.0215
Leishmania major hypothetical protein, conserved 0.0344 0.0528 0.3544
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0221 0.033 0.8908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Loa Loa (eye worm) calpain family protein 1 0.1076 0.17 0.6643
Mycobacterium ulcerans hypothetical protein 0.0021 0.001 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0094 0.0126 0.0804
Echinococcus multilocularis transmembrane protease serine 3 0.0021 0.001 0.0038
Brugia malayi hypothetical protein 0.0017 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Brugia malayi hypothetical protein 0.0026 0.0018 0.007
Echinococcus multilocularis EF hand domain containing family member A2 0.0094 0.0126 0.0492
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0509 0.0791 0.5336
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.002 0.0046
Onchocerca volvulus 0.0607 0.0949 0.7741
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Plasmodium vivax vivapain-1 0.0335 0.0513 0.4914
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.086 0.1354 0.5276
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1447 0.2293 0.2293
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0149 0.0215 0.206
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1613 0.2559 0.2559
Brugia malayi glutathione reductase 0.0097 0.0132 0.0513
Loa Loa (eye worm) programmed cell death protein 6 0.0096 0.013 0.0507
Leishmania major DNA polymerase eta, putative 0.0032 0.0028 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0126 0.0126
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0091 0.0091
Echinococcus granulosus calpain A 0.0666 0.1043 0.4075
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0126 0.1253
Plasmodium falciparum calpain 0.0296 0.045 0.4703
Echinococcus granulosus neuronal calcium sensor 0.0094 0.0126 0.0492
Brugia malayi calpain D 0.0296 0.045 0.1759
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0028 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Trypanosoma brucei cysteine peptidase C (CPC) 0.0602 0.094 0.6355
Loa Loa (eye worm) ctsf protein 0.0607 0.0949 0.3709
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0149 0.0215 0.0215
Brugia malayi beta-lactamase family protein 0.0037 0.0036 0.014
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0311 0.0474 0.1825
Schistosoma mansoni calmodulin 0.0094 0.0126 0.0126
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.002 0.1412
Mycobacterium ulcerans lipase LipD 0.0037 0.0036 0.3321
Trichomonas vaginalis caltractin, putative 0.0027 0.002 0.0123
Schistosoma mansoni calpain C (C02 family) 0.0666 0.1043 0.1043
Schistosoma mansoni cathepsin s 0.0186 0.0274 0.0274
Brugia malayi Uncoordinated protein 44 0.0015 0 0.00000002115
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0936 0.1475 0.5748
Trichomonas vaginalis kakapo, putative 0.0027 0.002 0.0123
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Toxoplasma gondii calmodulin, putative 0.0027 0.002 0.021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.007
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0509 0.0791 0.5336
Brugia malayi Papain family cysteine protease containing protein 0.0607 0.0949 0.3709
Trichomonas vaginalis centrin, putative 0.0027 0.002 0.0123
Schistosoma mansoni calmodulin-related 0.0027 0.002 0.002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0091 0.23
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0149 0.0215 0.2205
Schistosoma mansoni cathepsin F (C01 family) 0.0607 0.0949 0.0949
Trypanosoma brucei cytochrome P450, putative 0.0027 0.002 0.008
Trypanosoma cruzi conserved protein 0.0518 0.0805 0.3124
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.003 0.0318
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Mycobacterium tuberculosis Probable oxidoreductase 0.0246 0.037 1
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.0317 0.1209
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0126 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0602 0.094 0.9903
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.5136
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Onchocerca volvulus 0.0028 0.0021 0.017
Loa Loa (eye worm) myosin regulatory light chain 1 0.0027 0.002 0.0077
Entamoeba histolytica cysteine proteinase 1, putative 0.0335 0.0513 0.5361
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.0021 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0126 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.005 0.0165
Trypanosoma cruzi centrin, putative 0.0121 0.017 0.0632
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.0184 0.072
Echinococcus granulosus dna polymerase eta 0.0046 0.005 0.0196
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0094 0.0126 0.0804
Echinococcus granulosus lamin 0.0028 0.0021 0.0081
Schistosoma mansoni lamin 0.0028 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0375 0.0577 0.0577
Trichomonas vaginalis calcium binding protein, putative 0.0121 0.017 0.1715
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0149 0.0215 0.2197
Echinococcus multilocularis cathepsin b 0.1613 0.2559 1
Trypanosoma brucei Calpain-like protein 1.2 0.0656 0.1027 0.695
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0311 0.0474 0.3175
Onchocerca volvulus 0.0028 0.0021 0.017
Leishmania major small myristoylated protein-2 0.0668 0.1047 0.7081
Brugia malayi Thioredoxin reductase 0.0097 0.0132 0.0513
Brugia malayi Matrixin family protein 0.0053 0.0061 0.0238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0054 0.0439
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0036 0.0293
Brugia malayi Cathepsin L-like precursor 0.0422 0.0652 0.2546
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0016 0.0061
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.154 0.2443 0.9544
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Entamoeba histolytica calpain family cysteine protease, putative 0.0296 0.045 0.4697
Trypanosoma brucei I/6 autoantigen 0.0094 0.0126 0.0804
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.002 0.0078
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Echinococcus multilocularis calpain 0.0666 0.1043 0.4075
Brugia malayi Trypsin family protein 0.0021 0.001 0.0038
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0509 0.0791 0.3067
Echinococcus granulosus calpain 5 0.0666 0.1043 0.4075
Echinococcus granulosus calpain A 0.1542 0.2446 0.9559
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0509 0.0791 0.3067
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0812 0.1277 0.8654
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.003 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0073 0.0073
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0021 0.0081
Loa Loa (eye worm) hypothetical protein 0.0186 0.0274 0.107
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0091 0.0964
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.003 0.5
Trypanosoma brucei calpain-like protein, putative 0.0666 0.1043 0.7057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0425 0.0658 0.2546
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0008 0.0032
Loa Loa (eye worm) hypothetical protein 0.0094 0.0126 0.0492
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0036 0.0342
Plasmodium vivax vivapain-2 0.0607 0.0949 0.91
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.1209
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0036 0.014
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.154 0.2443 0.9544
Echinococcus granulosus programmed cell death protein 6 0.0029 0.0024 0.0092
Schistosoma mansoni thyroid hormone receptor 0.014 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0149 0.0215 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0344 0.0528 0.5523
Trypanosoma brucei Calpain-like protein 2 0.0638 0.0998 0.675
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0215 0.2197
Leishmania major centrin, putative 0.0094 0.0126 0.0804
Toxoplasma gondii troponin c, isotype gamma, putative 0.0094 0.0126 0.1329
Schistosoma mansoni reticulocalbin 0.0094 0.0126 0.0126
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Echinococcus multilocularis EF hand domain containing family member A2 0.0096 0.013 0.0507
Onchocerca volvulus 0.0021 0.001 0.008
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Schistosoma mansoni cathepsin F (C01 family) 0.0607 0.0949 0.0949
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0046 0.018
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0607 0.0949 0.3709
Trichomonas vaginalis esterase, putative 0.0037 0.0036 0.0293
Plasmodium vivax unspecified product 0.0335 0.0513 0.4914
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.003 0.0605
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0077
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0149 0.0215 0.2197
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Loa Loa (eye worm) cathepsin B 0.0602 0.094 0.3673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Giardia lamblia Cysteine protease 0.0149 0.0215 0.2219
Echinococcus multilocularis calcyphosin protein 0.0027 0.002 0.0077
Entamoeba histolytica grainin 2 0.0121 0.017 0.1715
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0132 0.0483
Plasmodium vivax serine-repeat antigen (SERA) 0.0149 0.0215 0.206
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.002 0.0123
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.0274 0.107
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0666 0.1043 0.4057
Mycobacterium tuberculosis Probable reductase 0.0221 0.033 0.8908
Schistosoma mansoni hypothetical protein 0.0375 0.0577 0.0577
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Echinococcus multilocularis calbindin 32 0.0096 0.013 0.0507
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0149 0.0215 0.206
Toxoplasma gondii thioredoxin reductase 0.0097 0.0132 0.1386
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.9139
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0046 0.018
Onchocerca volvulus 0.0094 0.0126 0.1028
Echinococcus granulosus transmembrane protease serine 3 0.0021 0.001 0.0038
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0022 0.0011 0.0011
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0666 0.1043 0.7057
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0079 0.0104 0.0404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Mycobacterium tuberculosis Probable dehydrogenase 0.0221 0.033 0.8908
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0091 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0607 0.0949 0.3709
Schistosoma mansoni hypothetical protein 0.0021 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0094 0.0126 0.0804
Onchocerca volvulus 0.0021 0.001 0.008
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.9139
Brugia malayi Protein kinase domain containing protein 0.0015 0 0.00000002115
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Trypanosoma brucei caltractin, putative 0.0121 0.017 0.11
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Schistosoma mansoni myosin regulatory light chain 0.0027 0.002 0.002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0149
Echinococcus granulosus Myosin regulatory light chain 0.0027 0.002 0.0077
Trypanosoma brucei protein I/6 0.0094 0.0126 0.0804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Onchocerca volvulus 0.0094 0.0126 0.1028
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Trypanosoma cruzi cruzipain precursor, putative 0.08 0.1258 0.49
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Echinococcus multilocularis Calcium binding protein 0.0027 0.002 0.0077
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0091 0.0357
Schistosoma mansoni thyroid hormone receptor 0.014 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0008 0.0032
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0149 0.0215 0.0215
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.003 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Entamoeba histolytica grainin 2 0.0027 0.002 0.0123
Brugia malayi Myosin regulatory light chain 1 0.0027 0.002 0.0077
Echinococcus multilocularis programmed cell death protein 0.0121 0.017 0.0662
Trypanosoma cruzi calmodulin, putative 0.0094 0.0126 0.0462
Entamoeba histolytica calmodulin, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0018 0.0038
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0011 0.0101
Toxoplasma gondii centrin family protein 0.0027 0.002 0.021
Echinococcus multilocularis musashi 0.0028 0.0021 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0073 0.0073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0036 0.014
Trichomonas vaginalis calcineurin B subunit, putative 0.0094 0.0126 0.1253
Brugia malayi Death domain containing protein 0.0015 0 0.00000002115
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0213 0.0317 0.2104
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0149 0.0215 0.2219
Trypanosoma brucei hypothetical protein, conserved 0.0344 0.0528 0.3544
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0311 0.0474 0.3175
Trypanosoma cruzi cysteine proteinase, putative 0.0335 0.0513 0.1977
Brugia malayi cathepsin F-like cysteine proteinase 0.0149 0.0215 0.084
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.0317 0.1209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Plasmodium falciparum cysteine proteinase falcipain 1 0.0335 0.0513 0.5365
Trypanosoma brucei hypothetical protein 0.0565 0.0882 0.5957
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0149 0.0215 0.206
Brugia malayi Protein kinase domain containing protein 0.0021 0.0011 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma brucei trypanothione reductase 0.0097 0.0132 0.084
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0081
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0607 0.0949 0.3709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Schistosoma mansoni DNA polymerase eta 0.0046 0.005 0.005
Giardia lamblia Hypothetical protein 0.0149 0.0215 0.2219
Echinococcus granulosus cathepsin l1 0.0607 0.0949 0.3709
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0073 0.0073
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.003 0.0232
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0036 0.0764
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.003 0.5
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0269 0.0408 0.2725
Toxoplasma gondii cathepsin CPL 0.0607 0.0949 1
Leishmania major kinesin, putative 0.037 0.0569 0.3825
Echinococcus granulosus calpain 0.0666 0.1043 0.4075
Plasmodium vivax unspecified product 0.0149 0.0215 0.206
Leishmania major cathepsin L-like protease 0.0607 0.0949 0.6417
Trypanosoma brucei calmodulin, putative 0.0094 0.0126 0.0804
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.9139
Echinococcus granulosus intermediate filament protein 0.0028 0.0021 0.0081
Trypanosoma brucei calpain, putative 0.0296 0.045 0.3014
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.2104
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0012 0.0045
Brugia malayi cathepsin L precursor 0.0149 0.0215 0.084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Giardia lamblia Cathepsin B precursor 0.0602 0.094 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Toxoplasma gondii centrin, putative 0.0094 0.0126 0.1329
Brugia malayi Cathepsin L-like cysteine proteinase 0.0422 0.0652 0.2546
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0027 0.002 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0086
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Schistosoma mansoni neuronal calcium sensor 0.0094 0.0126 0.0126
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0011 0.0041
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.0513 0.5361
Onchocerca volvulus 0.0021 0.001 0.008
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.003 0.0086
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Loa Loa (eye worm) hypothetical protein 0.0186 0.0274 0.107
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0623 0.0975 0.659
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1613 0.2559 0.2559
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.003 0.2629
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.003 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0036 0.0293
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.003 0.0149
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.003 0.0117
Loa Loa (eye worm) matrixin family protein 0.0048 0.0054 0.021
Plasmodium vivax serine-repeat antigen (SERA) 0.0149 0.0215 0.206
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0607 0.0949 1
Trichomonas vaginalis calcium binding protein, putative 0.0094 0.0126 0.1253
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.5253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Plasmodium falciparum glutathione reductase 0.0097 0.0132 0.1318
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Trypanosoma brucei antigen, putative 0.0666 0.1043 0.7057
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0036 0.0293
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0149 0.0215 0.2205
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0036 0.0293
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0602 0.094 0.6355
Leishmania major i/6 autoantigen-like protein 0.0094 0.0126 0.0804
Leishmania major calmodulin-like protein 0.0094 0.0126 0.0804
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0073 0.0284
Loa Loa (eye worm) cysteine protease 0.0607 0.0949 0.3709
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Loa Loa (eye worm) calmodulin-like protein 0.0094 0.0126 0.0492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0149 0.0215 0.2197
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0215 0.2197
Leishmania major centrin, putative,caltractin, putative 0.0094 0.0126 0.0804
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Trypanosoma brucei centrin, putative 0.0094 0.0126 0.0804
Leishmania major small myristoylated protein-3, putative 0.0311 0.0474 0.3175
Echinococcus multilocularis neuronal calcium sensor 0.0094 0.0126 0.0492
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.002 0.0046
Giardia lamblia Cathepsin L-like protease 0.0149 0.0215 0.2219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Toxoplasma gondii preprocathepsin c precursor, putative 0.0149 0.0215 0.2266
Brugia malayi RasGEF domain containing protein 0.0027 0.002 0.0077
Giardia lamblia Cysteine protease 0.0149 0.0215 0.2219
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0149 0.0215 0.206
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0036 0.014
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0269 0.0408 0.2725
Brugia malayi beta-lactamase family protein 0.0037 0.0036 0.014
Echinococcus multilocularis calpain 7 (C02 family) 0.0666 0.1043 0.4075
Leishmania major receptor-type adenylate cyclase a-like protein 0.0213 0.0317 0.2104
Entamoeba histolytica hypothetical protein, conserved 0.0096 0.013 0.1292
Trypanosoma cruzi I/6 autoantigen, putative 0.0094 0.0126 0.0462
Schistosoma mansoni reticulocalbin 0.0096 0.013 0.013
Leishmania major small myristoylated protein 4, putative 0.0578 0.0902 0.6095
Schistosoma mansoni rab 0.0094 0.0126 0.0126
Leishmania major calmodulin, putative 0.0094 0.0126 0.0804
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0011 0.0041
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.0132 0.0513
Brugia malayi calpain family protein 1 0.1447 0.2293 0.8959
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.0652 0.6837
Echinococcus multilocularis cathepsin L cysteine protease 0.0607 0.0949 0.3709
Trypanosoma brucei conserved protein 0.0222 0.0331 0.2204
Echinococcus multilocularis neurocalcin 0.0094 0.0126 0.0492
Brugia malayi Cytochrome P450 family protein 0.0027 0.002 0.0078
Loa Loa (eye worm) myosin Light Chain family member 0.0029 0.0024 0.0092
Leishmania major hypothetical protein, conserved 0.0026 0.0018 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0036 0.0036
Giardia lamblia Encystation-specific protease 0.0149 0.0215 0.2219
Plasmodium falciparum thioredoxin reductase 0.0097 0.0132 0.1318
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Toxoplasma gondii EF hand domain-containing protein 0.0027 0.002 0.021
Trichomonas vaginalis calmodulin-2, putative 0.0094 0.0126 0.1253
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.003 0.0086
Loa Loa (eye worm) hypothetical protein 0.0422 0.0652 0.2546
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0269 0.0408 0.1567
Brugia malayi Cathepsin L-like precursor 0.0422 0.0652 0.2546
Brugia malayi fibroinase precursor 0.0149 0.0215 0.084
Echinococcus granulosus cathepsin b 0.1613 0.2559 1
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0094 0.0126 0.1253
Brugia malayi Trypsin-like protease protein 5 0.0021 0.001 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0094 0.0126 0.0462
Plasmodium vivax SET domain protein, putative 0.006 0.0073 0.0695
Trypanosoma cruzi cysteine peptidase, putative 0.08 0.1258 0.49
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0149 0.0215 0.2197
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0094 0.0126 0.0462
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0666 0.1043 0.4057
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0221 0.033 0.8874
Brugia malayi cathepsin Z-like cysteine proteinase 0.0149 0.0215 0.084
Toxoplasma gondii calmodulin CAM1 0.0096 0.013 0.1369
Trypanosoma brucei calpain-like protein, putative 0.0936 0.1475 1
Schistosoma mansoni ef hand domain family member A2 0.0094 0.0126 0.0126
Schistosoma mansoni cathepsin B (C01 family) 0.0149 0.0215 0.0215
Entamoeba histolytica grainin, putative 0.0096 0.013 0.1292
Schistosoma mansoni calmodulin 0.0094 0.0126 0.0126
Loa Loa (eye worm) fibroinase 0.0607 0.0949 0.3709
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0027 0.002 0.0161
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Onchocerca volvulus 0.0027 0.002 0.0161
Plasmodium vivax glutathione reductase, putative 0.0097 0.0132 0.1259
Trypanosoma cruzi small myristoylated protein 1-2 0.0367 0.0564 0.2177
Schistosoma mansoni myosin light chain 0.0027 0.002 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.0201 0.0785
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Leishmania major META domain containing protein 0.0213 0.0317 0.2104
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0 0.00000002115
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.0317 0.1209
Onchocerca volvulus 0.0607 0.0949 0.7741
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0021 0.0081
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0011 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.0652 0.6837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.0132 0.0513
Leishmania major cysteine peptidase A (CPA) 0.0607 0.0949 0.6417
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0149 0.0215 0.2197
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.0513 0.5361
Loa Loa (eye worm) hypothetical protein 0.0422 0.0652 0.2546
Giardia lamblia Cathepsin L-like protease 0.0149 0.0215 0.2219
Schistosoma mansoni myosin regulatory light chain 0.0027 0.002 0.002
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.003 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.086 0.1354 0.9179
Loa Loa (eye worm) hypothetical protein 0.0046 0.005 0.0196
Brugia malayi hypothetical protein 0.0126 0.0178 0.0693
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1613 0.2559 1
Trichomonas vaginalis centrin, putative 0.0027 0.002 0.0123
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.2952
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0027 0.002 0.0161
Leishmania major calmodulin, putative 0.0094 0.0126 0.0804
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0296 0.045 0.4697
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0094 0.0126 0.0492
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.002 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0126 0.0491
Echinococcus granulosus Calcium binding protein 0.0027 0.002 0.0077
Plasmodium falciparum serine repeat antigen 4 0.0149 0.0215 0.2205
Trypanosoma brucei kinesin, putative 0.037 0.0569 0.3825
Trypanosoma cruzi small myristoylated protein 1-1 0.0367 0.0564 0.2177
Schistosoma mansoni hypothetical protein 0.0053 0.0062 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Entamoeba histolytica calcium-binding protein, putative 0.0094 0.0126 0.1253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0126 0.0126
Trypanosoma cruzi calmodulin, putative 0.0094 0.0126 0.0462
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0936 0.1475 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0016 0.0061
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.003 0.0149
Trichomonas vaginalis set domain proteins, putative 0.0477 0.0741 0.7785
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0018 0.0113
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0074
Trichomonas vaginalis calmodulin, putative 0.0096 0.013 0.1292
Plasmodium falciparum serine repeat antigen 7 0.0149 0.0215 0.2205
Onchocerca volvulus 0.0037 0.0036 0.0292
Brugia malayi Kringle domain containing protein 0.0021 0.0011 0.0041
Plasmodium vivax vivapain-3 0.0335 0.0513 0.4914
Loa Loa (eye worm) glutathione reductase 0.0097 0.0132 0.0513
Trypanosoma cruzi cysteine proteinase, putative 0.0335 0.0513 0.1977
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0221 0.033 0.8908
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0036 0.0481
Trypanosoma cruzi cysteine peptidase, putative 0.08 0.1258 0.49
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0246 0.037 1
Trypanosoma cruzi hypothetical protein, conserved 0.0344 0.0528 0.2037
Schistosoma mansoni lamin 0.0028 0.0021 0.0021
Echinococcus granulosus dna polymerase kappa 0.002 0.0008 0.0032
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0091 0.0091
Leishmania major cathepsin L-like protease 0.08 0.1258 0.8525
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0752 0.118 0.7991
Trypanosoma brucei calpain-like protein, putative 0.0666 0.1043 0.7057
Echinococcus multilocularis centrin 2 0.0094 0.0126 0.0492
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.5253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Loa Loa (eye worm) calpain 0.0666 0.1043 0.4075
Onchocerca volvulus 0.0477 0.0741 0.6042
Brugia malayi Trypsin family protein 0.0021 0.001 0.0038
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0079 0.0104 0.0404
Trypanosoma cruzi major cysteine proteinase, putative 0.0342 0.0524 0.2022
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Echinococcus granulosus cathepsin l cysteine peptidase 0.0607 0.0949 0.3709
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0126 0.0491
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Toxoplasma gondii cathepsin CPC1 0.0149 0.0215 0.2266
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.5136
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0936 0.1475 0.5748
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.154 0.2443 0.2442
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.003 0.0232
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0623 0.0975 0.3788
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0011 0.0114
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0172 0.0672
Entamoeba histolytica calpain large subunit domain III containing protein 0.037 0.0569 0.5961
Plasmodium falciparum serine repeat antigen 1 0.0149 0.0215 0.2205
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0656 0.1027 0.3995
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0012 0.0045
Trichomonas vaginalis calpain, putative 0.0296 0.045 0.4697
Brugia malayi MH2 domain containing protein 0.0122 0.0172 0.0672
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0565 0.0882 0.5957
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0623 0.0975 0.3788
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.2104
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0565 0.0882 0.5957
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0149 0.0215 0.206
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0752 0.118 0.7991
Brugia malayi Papain family cysteine protease containing protein 0.0149 0.0215 0.084
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0857 0.1348 0.9139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0296 0.045 0.4744
Plasmodium falciparum thioredoxin reductase 0.0034 0.003 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0149 0.0215 0.2197
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0021 0.001 0.0038
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0578 0.0902 0.3503
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0004 0.0004
Trypanosoma cruzi centrin-3 0.0121 0.017 0.0632
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0018 0.0171
Brugia malayi hypothetical protein 0.0021 0.001 0.0038
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0021 0.001 0.0038
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0036 0.0764
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0008 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0607 0.0949 0.3689
Mycobacterium ulcerans hypothetical protein 0.0037 0.0036 0.3321
Echinococcus multilocularis calpain A 0.1542 0.2446 0.9559
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0666 0.1043 0.4057
Mycobacterium tuberculosis Conserved protein 0.0037 0.0036 0.0764
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0186 0.0274 0.107
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Onchocerca volvulus 0.0607 0.0949 0.7741
Echinococcus multilocularis Ankyrin 0.0015 0 0.0001
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0274 0.107
Plasmodium falciparum serine repeat antigen 2 0.0149 0.0215 0.2205
Brugia malayi intermediate filament protein 0.0028 0.0021 0.0081
Loa Loa (eye worm) hypothetical protein 0.0094 0.0126 0.0492
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0073 0.0767
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0213 0.0317 0.2104
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0149 0.0215 0.2205
Schistosoma mansoni intermediate filament proteins 0.0028 0.0021 0.0021
Schistosoma mansoni calpain-7 (C02 family) 0.0666 0.1043 0.1043
Trypanosoma brucei Calpain-like protein CALP1.3 0.0509 0.0791 0.5336
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0077
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0149 0.0215 0.084
Leishmania major hypothetical protein, conserved 0.0096 0.013 0.0829
Onchocerca volvulus Matrilysin homolog 0.0048 0.0054 0.0439
Mycobacterium tuberculosis Conserved protein 0.0037 0.0036 0.0764
Onchocerca volvulus 0.0027 0.002 0.0161
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0073 0.0284
Trichomonas vaginalis calmodulin, putative 0.0094 0.0126 0.1253
Leishmania major protein kinase, putative 0.0094 0.0126 0.0804
Trypanosoma brucei unspecified product 0.0213 0.0317 0.2104
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0044
Echinococcus granulosus cathepsin L 0.0149 0.0215 0.084
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.1138 0.1799 0.1799
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.154 0.2443 0.2442
Loa Loa (eye worm) beta-lactamase 0.0037 0.0036 0.014
Brugia malayi Cathepsin L-like precursor 0.0607 0.0949 0.3709
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0509 0.0791 0.3067
Leishmania major calpain protease-like protein 0.0296 0.045 0.3014
Entamoeba histolytica cysteine proteinase, putative 0.0607 0.0949 1
Leishmania major small myristoylated protein-1 0.0367 0.0564 0.3788
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Brugia malayi Hemopexin family protein 0.0031 0.0026 0.0101
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0296 0.045 0.3014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0149 0.0215 0.2197
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Trichomonas vaginalis calmodulin, putative 0.0121 0.017 0.1715
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0036 0.3321
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.086 0.1354 0.5276
Echinococcus granulosus EF hand domain containing family member A2 0.0096 0.013 0.0507
Trypanosoma cruzi cysteine peptidase, putative 0.0335 0.0513 0.1977
Trypanosoma brucei small myristoylated protein 1-2 0.0367 0.0564 0.3788
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0215 0.0215
Trichomonas vaginalis calmodulin, putative 0.0027 0.002 0.0123
Onchocerca volvulus 0.0422 0.0652 0.5313
Brugia malayi Papain family cysteine protease containing protein 0.0149 0.0215 0.084
Loa Loa (eye worm) trypsin family protein 0.0021 0.001 0.0038
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0149 0.0215 0.2219
Echinococcus multilocularis Mastin 0.0021 0.001 0.0038
Echinococcus multilocularis calpain family protein 1, d 0.1076 0.17 0.6643
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0091 0.0357
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Schistosoma mansoni hypothetical protein 0.0031 0.0026 0.0026
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0018 0.0038
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.003 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Brugia malayi calpain 5 0.037 0.0569 0.2224
Giardia lamblia Cathepsin B precursor 0.0149 0.0215 0.2219
Brugia malayi Matrixin family protein 0.0022 0.0011 0.0044
Plasmodium falciparum serine repeat antigen 8 0.0149 0.0215 0.2205
Plasmodium vivax centrin-1, putative 0.0094 0.0126 0.1207
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.005 0.0196
Brugia malayi calcium-binding protein 0.0094 0.0126 0.0492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Schistosoma mansoni neuronal calcium sensor 0.0094 0.0126 0.0126
Plasmodium falciparum glutathione reductase 0.0034 0.003 0.0242
Mycobacterium ulcerans beta-lactamase 0.0037 0.0036 0.3321
Trypanosoma cruzi major cysteine proteinase, putative 0.0149 0.0215 0.0811
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.003 0.0287
Schistosoma mansoni hypothetical protein 0.0094 0.0126 0.0126
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Echinococcus granulosus calpain 7 C02 family 0.0666 0.1043 0.4075
Onchocerca volvulus 0.078 0.1226 1
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0053 0.0053
Plasmodium falciparum centrin-4 0.0027 0.002 0.0133
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0936 0.1475 1
Onchocerca volvulus 0.0037 0.0036 0.0292
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0036 0.0036
Loa Loa (eye worm) RecQ helicase 0.0022 0.0012 0.0045
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0094 0.0126 0.0462
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Onchocerca volvulus 0.0607 0.0949 0.7741
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0094 0.0126 0.0126
Echinococcus granulosus cathepsin l1 0.0422 0.0652 0.2546
Loa Loa (eye worm) hypothetical protein 0.1447 0.2293 0.8959
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.0184 0.072
Trypanosoma cruzi kinesin, putative 0.037 0.0569 0.2199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Echinococcus granulosus calbindin 32 0.0096 0.013 0.0507
Leishmania major trypanothione reductase 0.0097 0.0132 0.084
Entamoeba histolytica cysteine protease, putative 0.0607 0.0949 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0021 0.001 0.0038
Echinococcus granulosus cathepsin L cysteine protease 0.0335 0.0513 0.2003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.014
Brugia malayi calpain 7 0.0666 0.1043 0.4075
Echinococcus granulosus calmodulin 0.0094 0.0126 0.0492
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0096 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0607 0.0949 0.3709
Echinococcus granulosus enteropeptidase 0.0021 0.001 0.0038
Trichomonas vaginalis calcium binding proteins, putative 0.0094 0.0126 0.1253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.0513 0.344
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0602 0.094 0.3653
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0149 0.0215 0.206
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0509 0.0791 0.5336
Brugia malayi Matrixin family protein 0.0022 0.0011 0.0044
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0021 0.001 0.001
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0149 0.0215 0.2197
Entamoeba histolytica cysteine protease, putative 0.0149 0.0215 0.2197
Onchocerca volvulus 0.0021 0.001 0.008
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0638 0.0998 0.675
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0038
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0018 0.0067
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0269 0.0408 0.2725
Echinococcus multilocularis calumenin 0.0096 0.013 0.0507
Echinococcus granulosus calumenin 0.0096 0.013 0.0507
Echinococcus granulosus EF hand domain containing family member A2 0.0094 0.0126 0.0492
Schistosoma mansoni Mername-AA248 (C02 family) 0.0666 0.1043 0.1043
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0036 0.0764
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0172 0.0672
Loa Loa (eye worm) hypothetical protein 0.0149 0.0215 0.084
Entamoeba histolytica cysteine proteinase, putative 0.0607 0.0949 1
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0094 0.0126 0.0492
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0036 0.0188
Brugia malayi EF hand family protein 0.0094 0.0126 0.0492
Schistosoma mansoni calmodulin related calcium binding protein 0.0094 0.0126 0.0126
Schistosoma mansoni calpain-2 (C02 family) 0.0296 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.078 0.1226 0.4791
Brugia malayi Pre-SET motif family protein 0.0419 0.0648 0.2532
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Leishmania major cathepsin L-like protease 0.08 0.1258 0.8525
Onchocerca volvulus 0.0149 0.0215 0.1753
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0509 0.0791 0.3067
Echinococcus granulosus calcyphosin protein 0.0027 0.002 0.0077
Leishmania major cytochrome p450-like protein 0.0027 0.002 0.008
Mycobacterium ulcerans hydrolase 0.0027 0.0019 0.129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.0949 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0812 0.1277 0.8654
Echinococcus multilocularis calpain 5 0.0666 0.1043 0.4075
Echinococcus multilocularis cysteine protease 0.0607 0.0949 0.3709
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Schistosoma mansoni calpain-7 (C02 family) 0.0666 0.1043 0.1043
Leishmania major calpain family cysteine protease-like protein 0.0509 0.0791 0.5336
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0335 0.0513 0.5361
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0936 0.1475 0.5748
Brugia malayi Papain family cysteine protease containing protein 0.0149 0.0215 0.084
Schistosoma mansoni hypothetical protein 0.013 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.1613 0.2559 1
Schistosoma mansoni cathepsin C 0.0149 0.0215 0.0215
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0666 0.1043 0.4057
Leishmania major calcineurin B subunit, putative 0.0094 0.0126 0.0804
Schistosoma mansoni calpain (C02 family) 0.0666 0.1043 0.1043
Brugia malayi Cytochrome P450 family protein 0.0027 0.002 0.0078
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.003 0.0149
Loa Loa (eye worm) hypothetical protein 0.0186 0.0274 0.107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0021 0.0081
Echinococcus multilocularis programmed cell death protein 6 0.0029 0.0024 0.0092
Onchocerca volvulus 0.0607 0.0949 0.7741
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0 0.00000002115
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0094 0.0126 0.1253
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0027 0.0019 0.0074
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.003 0.0149
Treponema pallidum NADH oxidase 0.0034 0.003 0.5
Brugia malayi cathepsin Z-like cysteine proteinase 0.0149 0.0215 0.084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.0949 1
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.0274 0.1042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0149 0.0215 0.084
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0018 0.0113
Trypanosoma cruzi caltractin, putative 0.0094 0.0126 0.0462
Onchocerca volvulus 0.0021 0.001 0.008
Giardia lamblia Programmed cell death protein-like protein 0.0027 0.002 0.0124
Toxoplasma gondii cathepsin CPC2 0.0149 0.0215 0.2266
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0311 0.0474 0.1825
Trypanosoma brucei cysteine peptidase, putative 0.0509 0.0791 0.5336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Plasmodium vivax calpain, putative 0.0666 0.1043 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.0652 0.6837
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0656 0.1027 0.695
Mycobacterium leprae Probable lipase LipE 0.0037 0.0036 0.0481
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.049 0.0761 0.5136
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0213 0.0317 0.2104
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.001 0.001
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.003 0.0287
Echinococcus multilocularis cathepsin L 0.0335 0.0513 0.2003
Brugia malayi Trypsin family protein 0.0021 0.001 0.0038
Echinococcus multilocularis lamin 0.0028 0.0021 0.0081
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0936 0.1475 1
Onchocerca volvulus Cathepsin L homolog 0.0607 0.0949 0.7741
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0041
Giardia lamblia Cathepsin L precursor 0.0149 0.0215 0.2219
Trypanosoma cruzi kinesin, putative 0.037 0.0569 0.2199
Trichomonas vaginalis calcium binding protein, putative 0.0094 0.0126 0.1253
Echinococcus granulosus bloom syndrome protein 0.0022 0.0012 0.0045
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0011 0.0036
Trypanosoma cruzi centrin, putative 0.0121 0.017 0.0632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.08 0.1258 0.8525
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0094 0.0126 0.0462
Trypanosoma brucei calpain-like protein, putative 0.0666 0.1043 0.7057
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.001 0.001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0561 0.0874 0.3396
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0335 0.0513 0.0513
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0509 0.0791 0.3067
Leishmania major hypothetical protein, conserved 0.0021 0.0011 0.0017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0069 0.027
Echinococcus granulosus glycoprotein Antigen 5 0.0021 0.001 0.0038
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0008 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0215 0.2197
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0021 0.001 0.0038
Trichomonas vaginalis calpain, putative 0.0296 0.045 0.4697
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0073 0.0284
Plasmodium falciparum serine repeat antigen 6 0.0149 0.0215 0.2205
Trypanosoma brucei calpain, putative 0.0565 0.0882 0.5957
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.0513 0.5361
Onchocerca volvulus 0.0607 0.0949 0.7741
Echinococcus multilocularis dna polymerase kappa 0.002 0.0008 0.0032
Onchocerca volvulus Matrilysin homolog 0.0022 0.0011 0.0092
Onchocerca volvulus 0.0021 0.0011 0.0086
Trichomonas vaginalis caltractin, putative 0.0027 0.002 0.0123

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 117 uM Inhibition of Plasmodium falciparum recombinant SAHH ChEMBL. 18374570
IC50 (binding) = 123 uM Inhibition of human recombinant SAHH ChEMBL. 18374570
IC50 (binding) = 123 uM Inhibition of human recombinant SAHH ChEMBL. 18374570
Ratio IC50 (binding) = 0.95 Selectivity ratio of human recombinant SAHH to Plasmodium falciparum recombinant SAHH ChEMBL. 18374570

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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