Detailed information for compound 519478

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.526 | Formula: C23H32N4O2
  • H donors: 0 H acceptors: 4 LogP: 5.71 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCn1nnc(c1)CN1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C23H32N4O2/c1-2-3-4-5-6-7-8-9-10-13-16-26-17-19(24-25-26)18-27-22(28)20-14-11-12-15-21(20)23(27)29/h11-12,14-15,17H,2-10,13,16,18H2,1H3
  • InChiKey: SZKCCOJTTGKTBC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0174 0.0174
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.019 0.019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0037 0.0174 0.0264
Brugia malayi N-terminal motif family protein 0.0196 0.1262 0.1287
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0013 0.0011 0.0011
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.0165 0.0168
Onchocerca volvulus 0.0029 0.0125 0.0188
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Echinococcus granulosus acetylcholinesterase 0.0068 0.0384 0.0384
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0219 0.0696
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0048 0.0048
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0104 0.0635 0.0647
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0013 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.004 0.0126
Toxoplasma gondii exonuclease III APE 0.002 0.0063 0.0514
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Plasmodium vivax multidomain scavenger receptor, putative 0.0061 0.0341 0.4456
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Plasmodium falciparum DNA topoisomerase 2 0.0026 0.0103 0.1863
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0268 0.0273
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0103 0.0155
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0255 0.0255
Schistosoma mansoni gliotactin 0.0011 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0117 0.072 0.072
Trypanosoma brucei developmentally regulated phosphoprotein 0.0472 0.314 1
Echinococcus multilocularis cysteine protease 0.0035 0.0165 0.0165
Schistosoma mansoni cathepsin s 0.0012 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0035 0.0165 0.388
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0026 0.0103 0.5383
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0726 0.0726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Echinococcus multilocularis expressed protein 0.0757 0.5086 0.5086
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0103 0.0155
Plasmodium vivax SET domain protein, putative 0.0123 0.0761 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0092 0.2449
Onchocerca volvulus 0.0013 0.0011 0.0014
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0037 0.0174 0.0174
Brugia malayi MAP kinase sur-1 0.005 0.0268 0.0273
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0025 0.0025
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0025 0.0079
Onchocerca volvulus 0.005 0.0261 0.0397
Schistosoma mansoni pcd6 interacting protein-related 0.0037 0.0174 0.0174
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.002 0.002
Brugia malayi Endoplasmin precursor 0.0026 0.0103 0.0105
Echinococcus granulosus expressed protein 0.0757 0.5086 0.5086
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0472 0.314 0.314
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0001 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0761 0.0761
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0268 0.0268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0384 0.0384
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0189 0.0189
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1579 0.1579
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0211 0.0211
Echinococcus granulosus histone acetyltransferase KAT2B 0.0166 0.1052 0.1052
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0124 0.0126
Schistosoma mansoni microtubule-associated protein tau 0.1478 1 1
Brugia malayi hypothetical protein 0.0104 0.0635 0.0647
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Brugia malayi excitatory GABA receptor EXP-1A 0.0013 0.0011 0.0011
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Plasmodium falciparum LCCL domain-containing protein 0.0061 0.0341 1
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0016 0.0017
Schistosoma mansoni lipoxygenase 0.0171 0.1092 0.1092
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0054 0.0289 0.0295
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0165 0.1048 0.8542
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0085 0.0087
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0189 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0221 0.1431 0.1459
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0165 0.025
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Schistosoma mansoni survival motor neuron protein 0.005 0.0261 0.0261
Onchocerca volvulus 0.0037 0.0174 0.0264
Plasmodium falciparum heat shock protein 90 0.0026 0.0103 0.1863
Brugia malayi regulator of G-protein signaling egl-10 0.0049 0.0255 0.026
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Onchocerca volvulus 0.0039 0.019 0.0289
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0092 0.0291
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0092 0.1163
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0205 0.1325 0.1325
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0013 0.0011 0.0011
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0026 0.0103 1
Trypanosoma brucei protein tyrosine phosphatase 1 0.0037 0.0174 0.0555
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0174 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0227
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0126
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.019 0.117
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0189 0.0189
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0852 0.5736 0.5851
Brugia malayi nuclear receptor NHR-67 0.0104 0.0635 0.0647
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0189 0.0192
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Brugia malayi Rhodanese-like domain containing protein 0.0058 0.032 0.0326
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0255 0.0255
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Schistosoma mansoni coup transcription factor 0.0221 0.1431 0.1431
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0003 0.0003
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0011 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0192 0.0192
Onchocerca volvulus 0.0037 0.0174 0.0264
Brugia malayi PXA domain containing protein 0.0039 0.0189 0.0192
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0189 0.0192
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0011 0.0011
Brugia malayi hypothetical protein 0.0061 0.0341 0.0348
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0103 0.0155
Onchocerca volvulus 0.0035 0.0165 0.025
Onchocerca volvulus 0.0029 0.0124 0.0187
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0013 0.0011 0.0011
Brugia malayi kinase, mitochondrial precursor 0.0472 0.314 0.3203
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0221 0.1431 0.1431
Loa Loa (eye worm) GABA receptor subunit 0.0056 0.0304 0.031
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Echinococcus granulosus cathepsin l1 0.0024 0.0085 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Echinococcus granulosus histone lysine methyltransferase setb 0.0123 0.0761 0.0761
Brugia malayi beta-lactamase 0.0039 0.019 0.0194
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0026 0.0103 0.0103
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0374 0.3046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.0201
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0386 0.1228
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0192 0.0192
Echinococcus multilocularis musashi 0.0029 0.0124 0.0124
Trichomonas vaginalis pten, drome, putative 0.0037 0.0174 0.0264
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0221 0.1431 0.1431
Leishmania major cathepsin L-like protease 0.0135 0.0843 0.2685
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Mycobacterium ulcerans putative regultory protein 0.0026 0.0103 0.2744
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Brugia malayi Cathepsin L-like precursor 0.0024 0.0085 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0221 0.1431 0.1459
Onchocerca volvulus 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0144
Echinococcus granulosus heat shock protein 90 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0165 0.025
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0268 0.0268
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Brugia malayi Carboxylesterase family protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0191 0.1227 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.032 0.0326
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.0635 0.0635
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0221 0.1431 0.1431
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0104 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.042 0.2787 0.2787
Loa Loa (eye worm) acetyltransferase 0.017 0.1085 0.1107
Brugia malayi Steroid receptor seven-up type 2 0.0221 0.1431 0.1459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0048 0.0071
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0062 0.0344 0.0351
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0174 0.0555
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0189 0.0189
Onchocerca volvulus 0.0037 0.0174 0.0264
Brugia malayi Carboxylesterase family protein 0.0068 0.0384 0.0392
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0386 0.1228
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0221 0.1431 0.1431
Entamoeba histolytica hypothetical protein 0.0039 0.019 0.4583
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0219 0.0219
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0268 0.0853
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0011 0.0011
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0013 0.0011 0.0011
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Brugia malayi steroid hormone receptor 0.0221 0.1431 0.1459
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0141 0.045
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0189 0.0286
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0013 0.0011 0.0011
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0174 0.0174
Mycobacterium ulcerans hypothetical protein 0.0039 0.019 0.5098
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Leishmania major developmentally regulated phosphoprotein-like protein 0.0472 0.314 1
Echinococcus granulosus Polycystic kidney disease protein 0.0061 0.0341 0.0341
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.0761 0.0761
Loa Loa (eye worm) heat shock protein 90 0.0026 0.0103 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0048 0.0153
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0103 0.0327
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.019 0.019
Loa Loa (eye worm) protein tyrosine phosphatase 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0087
Schistosoma mansoni acetylcholinesterase 0.0011 0.0001 0.0001
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.019 0.0607
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0174 0.0174
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0063 0.1686
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0192 0.0196
Echinococcus multilocularis 0.0037 0.0174 0.0174
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0004 0.0004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) carboxylesterase 0.0011 0.0001 0.0001
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0174 0.0555
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0026 0.0103 0.063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0761 0.0761
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.019 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0165 0.0525
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0026 0.0103 0.063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0221 0.1431 0.1431
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0221 0.1431 0.1431
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0265 0.2161
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Brugia malayi CXXC zinc finger family protein 0.0029 0.0125 0.0127
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.019 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Trichomonas vaginalis esterase, putative 0.0039 0.019 0.0289
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0048 0.0637
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0037 0.0174 0.0174
Leishmania major DNA polymerase eta, putative 0.0015 0.0025 0.0079
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0341 0.0341
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0189 0.0189
Onchocerca volvulus 4.1 G protein, putative homolog 0.0037 0.0174 0.0264
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0219 0.0696
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0056 0.0304 0.031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0221 0.1431 0.1459
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0092 0.1487
Loa Loa (eye worm) carboxylesterase 0.0068 0.0384 0.0392
Mycobacterium tuberculosis Conserved protein 0.0026 0.0103 0.063
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0472 0.314 0.314
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Brugia malayi Rhodanese-like domain containing protein 0.0058 0.032 0.0326
Brugia malayi photoreceptor-specific nuclear receptor 0.0221 0.1431 0.1459
Schistosoma mansoni RAR-like nuclear receptor 0.0221 0.1431 0.1431
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0165 0.388
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0386 0.0386
Trichomonas vaginalis cdc25c, putative 0.0058 0.032 0.0487
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Echinococcus multilocularis heat shock protein 90 0.0026 0.0103 0.0103
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.1629 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0192 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0221 0.1431 0.1459
Schistosoma mansoni hypothetical protein 0.0539 0.3597 0.3597
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0221 0.1431 0.1459
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0026 0.0103 0.2744
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0125 0.0127
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0011 0.0011
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0103 0.2151
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0048 0.0049
Schistosoma mansoni retinoic acid receptor RXR 0.0322 0.2121 0.2121
Schistosoma mansoni nuclear hormone receptor 0.0104 0.0635 0.0635
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0012 0.0003 0.0003
Brugia malayi hypothetical protein 0.0061 0.0341 0.0348
Trichomonas vaginalis DNA topoisomerase II, putative 0.0026 0.0103 0.0155
Loa Loa (eye worm) hypothetical protein 0.0058 0.032 0.0326
Mycobacterium leprae conserved hypothetical protein 0.0039 0.019 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0013 0.0011 0.0014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.0223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0105
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0221 0.1431 0.1459
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0174 0.0174
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0092 0.4804
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Schistosoma mansoni regulator of G protein signaling 0.0049 0.0255 0.0255
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0037 0.0174 0.4135
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.019 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0386 0.0393
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0189 0.0189
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0189 0.0192
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0063 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0048 0.0153
Plasmodium vivax DNA gyrase subunit B, putative 0.0026 0.0103 0.1308
Brugia malayi ecdysone receptor 0.0104 0.0635 0.0647
Entamoeba histolytica hypothetical protein 0.0025 0.0092 0.1845
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0037 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1449 0.9804 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0063 0.1055
Trichomonas vaginalis endoplasmin, putative 0.0026 0.0103 0.0155
Leishmania major DNA topoisomerase ii 0.0026 0.0103 0.0327
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0344 0.0344
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0165 0.025
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.0201
Loa Loa (eye worm) hypothetical protein 0.0061 0.0341 0.0348
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Brugia malayi nuclear hormone receptor family member odr-7 0.0104 0.0635 0.0647
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0219 0.0696
Brugia malayi heat shock protein 90 0.0026 0.0103 0.0105
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Brugia malayi Nuclear hormone receptor E75 0.0104 0.0635 0.0647
Plasmodium vivax endoplasmin, putative 0.0026 0.0103 0.1308
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0221 0.1431 0.1431
Plasmodium vivax vivapain-2 0.0035 0.0165 0.2132
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0211 0.0672
Echinococcus multilocularis cysteine protease 0.0035 0.0165 0.0165
Brugia malayi hypothetical protein 0.0117 0.072 0.0734
Entamoeba histolytica DNA topoisomerase II, putative 0.0026 0.0103 0.2151
Echinococcus granulosus FTZ F1 alpha 0.0221 0.1431 0.1431
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Echinococcus granulosus heat shock protein 0.0026 0.0103 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.004 0.0126
Onchocerca volvulus Cathepsin F homolog 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0016 0.0016
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0521 0.0521
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0016 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0843 0.2685
Trypanosoma cruzi cruzipain precursor, putative 0.0135 0.0843 0.2685
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0374 0.119
Echinococcus multilocularis cpg binding protein 0.0031 0.0136 0.0136
Schistosoma mansoni endoplasmin 0.0026 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0221 0.1431 0.1459
Brugia malayi Cytochrome P450 family protein 0.0053 0.0283 0.0288
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Echinococcus multilocularis ecdysone induced protein 78C 0.0221 0.1431 0.1431
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0026 0.0103 0.2744
Giardia lamblia DINP protein human, muc B family 0.0022 0.0071 0.0396
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0103 0.0155
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0058 0.032 0.0487
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0104 0.0635 0.0647
Onchocerca volvulus 0.0013 0.0011 0.0014
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0011 0.0011
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0219 0.0219
Loa Loa (eye worm) endoplasmin 0.0026 0.0103 0.0105
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0103 0.0327
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0237 0.587
Schistosoma mansoni cpg binding protein 0.0029 0.0125 0.0125
Brugia malayi Carboxylesterase family protein 0.0011 0.0001 0.0001
Plasmodium vivax unspecified product 0.0018 0.0048 0.0588
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0268 0.0408
Onchocerca volvulus 0.0013 0.0011 0.0014
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0219 0.5368
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0386 0.1228
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.019 0.5098
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.019 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus granulosus cpg binding protein 0.0031 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0061 0.0341 0.0341
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Onchocerca volvulus 0.097 0.6539 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0211 0.0321
Onchocerca volvulus 0.0104 0.0635 0.0968
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0165 0.0525
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0103 0.0155
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0117 0.072 0.072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0221 0.1431 0.1459
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.019 0.117
Schistosoma mansoni endoplasmin 0.0026 0.0103 0.0103
Brugia malayi hypothetical protein 0.0243 0.1579 0.1611
Trypanosoma brucei unspecified product 0.0035 0.0165 0.0525
Brugia malayi follicle stimulating hormone receptor 0.0252 0.164 0.1673
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0191 0.0191
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0055 0.0297 0.0303
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.072 0.0734
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0001 0.0001
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0026 0.0103 0.0155
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0165 0.0165
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0211 0.0321
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0268 0.0268
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0048 0.0048
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Mycobacterium ulcerans DNA gyrase subunit B 0.0026 0.0103 0.2744
Schistosoma mansoni lipoxygenase 0.0061 0.0341 0.0341
Echinococcus granulosus dna polymerase eta 0.0015 0.0025 0.0025
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0174 0.0174
Loa Loa (eye worm) LGC-31 protein 0.0013 0.0011 0.0011
Schistosoma mansoni lamin 0.0029 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0085 0.0128
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0001 0.0001
Onchocerca volvulus Putative nachr subunit 0.0013 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0189 0.0192
Onchocerca volvulus 0.0013 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Mycobacterium tuberculosis Conserved protein 0.0039 0.019 0.117
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0063 0.0064
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0026 0.0103 0.2744
Loa Loa (eye worm) hypothetical protein 0.0472 0.314 0.3203
Echinococcus granulosus lamin 0.0029 0.0124 0.0124
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0026 0.0103 0.0105
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0165 0.0168
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0261 0.0266
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Onchocerca volvulus 0.0058 0.032 0.0487
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0472 0.314 0.314
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Schistosoma mansoni thyroid hormone receptor 0.0221 0.1431 0.1431
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0174 0.0174
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Entamoeba histolytica hypothetical protein 0.0039 0.0189 0.454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0221 0.1431 0.1459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Schistosoma mansoni nuclear hormone receptor 0.0104 0.0635 0.0635
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0165 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0221 0.1431 0.1459
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0037 0.0174 0.0174
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0221 0.1431 0.1431
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.019 0.117
Echinococcus multilocularis heat shock protein 0.0026 0.0103 0.0103
Giardia lamblia Protein tyrosine phosphatase 0.0037 0.0174 0.5421
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Plasmodium vivax DNA topoisomerase II, putative 0.0026 0.0103 0.1308
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.019 0.0289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0219 0.0219
Echinococcus multilocularis cathepsin L 0.0018 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0196 0.1262 0.1287
Brugia malayi Cation transporter family protein 0.0062 0.0344 0.0351
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Brugia malayi polk-prov protein 0.0032 0.0141 0.0144
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0013 0.0011 0.0011
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0265 0.3455
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0026 0.0103 1
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0058 0.032 0.032
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0026 0.0103 0.1863
Mycobacterium ulcerans lipase LipD 0.0039 0.019 0.5098
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.019 0.0289
Onchocerca volvulus 0.0039 0.019 0.0289
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0058 0.032 0.032
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Echinococcus granulosus acetylcholinesterase 0.0068 0.0384 0.0384
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Onchocerca volvulus 0.0037 0.0174 0.0264
Brugia malayi Pre-SET motif family protein 0.0852 0.5736 0.5851
Echinococcus multilocularis dna polymerase eta 0.0015 0.0025 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0123 0.0761 0.0761
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0381 0.0381
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0265 0.2161
Mycobacterium ulcerans beta-lactamase 0.0039 0.019 0.5098
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0341 0.0341
Loa Loa (eye worm) DR-78 0.0104 0.0635 0.0647
Loa Loa (eye worm) hypothetical protein 0.0384 0.254 0.259
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0374 0.0374
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1449 0.9804 0.9804
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0013 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0012 0.0003 0.0011
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0026 0.0103 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0221 0.1431 0.1431
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0189 0.0189
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0103 0.0327
Echinococcus granulosus thyroid hormone receptor alpha 0.0104 0.0635 0.0635
Leishmania major mitochondrial DNA topoisomerase II 0.0026 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0103 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0165 0.025
Brugia malayi hypothetical protein 0.0039 0.0189 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0141 0.045
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.0165 0.0165
Echinococcus multilocularis nuclear receptor nhr 48 0.0104 0.0635 0.0635
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0063 0.0201
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Brugia malayi nuclear hormone receptor 0.0104 0.0635 0.0647
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0192 0.0192
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Schistosoma mansoni intermediate filament proteins 0.0029 0.0124 0.0124
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0011 0.0011
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0265 0.0403
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0268 0.0408
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1449 0.9804 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0174 0.4135
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0219 0.0219
Leishmania major tyrosine specific protein phosphatase, putative 0.0037 0.0174 0.0555
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0103 0.0155
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Leishmania major hypothetical protein, conserved 0.0039 0.019 0.0607
Brugia malayi cathepsin L-like precursor 0.0024 0.0085 0.0087
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0521 0.0521
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0268 0.0853
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.0635 0.0968
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0221 0.1431 0.1459
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0265 0.0403
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0219 0.0219
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1449 0.9804 0.9804
Echinococcus granulosus geminin 0.0539 0.3597 0.3597
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0124 0.0126
Onchocerca volvulus Protein ultraspiracle homolog 0.0221 0.1431 0.2186
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0189 0.0189
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.026
Onchocerca volvulus 0.0035 0.0165 0.025
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0374 0.0374
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0165 0.1048 0.3338
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0085 0.0128
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0268 0.0268
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Schistosoma mansoni nuclear hormone receptor 0.0221 0.1431 0.1431
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0001 0.0039
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0268 0.0853
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0384 0.0384
Brugia malayi Pre-SET motif family protein 0.0123 0.0761 0.0776
Schistosoma mansoni z-protein (S1r protein) 0.0049 0.0255 0.0255
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0268 0.0853
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0026 0.0103 0.0327
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0013 0.0011 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1579 0.1579
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0103 0.1929
Mycobacterium leprae Probable lipase LipE 0.0039 0.019 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0092 0.0562
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.0165 0.3992
Schistosoma mansoni hypothetical protein 0.0155 0.0984 0.0984
Echinococcus multilocularis dnaJ subfamily B 0.042 0.2787 0.2787
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Brugia malayi Carboxylesterase family protein 0.0011 0.0001 0.0001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0221 0.1431 0.1431
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0268 0.0853
Plasmodium vivax heat shock protein 86, putative 0.0026 0.0103 0.1308
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0063 0.0515
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0013 0.0011 0.0011
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi nuclear receptor RXR 0.0104 0.0635 0.0647
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Schistosoma mansoni DNA polymerase eta 0.0015 0.0025 0.0025
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.019 0.019
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0189 0.0189
Schistosoma mansoni heat shock protein 0.0026 0.0103 0.0103
Schistosoma mansoni cpg binding protein 0.0031 0.0136 0.0136
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0237 0.6441
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0087
Brugia malayi Carboxylesterase family protein 0.0011 0.0001 0.0001
Schistosoma mansoni pyruvate dehydrogenase 0.0472 0.314 0.314
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0103 0.0836
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0037 0.0174 0.0174
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0026 0.0103 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Echinococcus granulosus ecdysone induced protein 78C 0.0221 0.1431 0.1431
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0221 0.1431 0.1459
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Mycobacterium tuberculosis Possible two component sensor kinase 0.0026 0.0103 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Mycobacterium tuberculosis Conserved protein 0.0039 0.019 0.117
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0189 0.0189
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0104 0.0635 0.0635
Brugia malayi hypothetical protein 0.0104 0.0635 0.0647
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Brugia malayi orphan nuclear receptor NR2E1 0.0104 0.0635 0.0647
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0092 0.7209
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0026 0.0103 0.063
Loa Loa (eye worm) doublecortin family protein 0.0061 0.0341 0.0348
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0026 0.0103 0.063
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0103 0.0327
Onchocerca volvulus 0.0061 0.0341 0.0519
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0192 0.0196
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0062 0.0344 0.0351
Loa Loa (eye worm) hypothetical protein 0.0123 0.0761 0.0776
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.1262 0.1928
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0165 0.1048 0.3338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.019 0.0194
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0221 0.1431 0.2186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0221 0.1431 0.1459
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0171 0.1092 0.1092
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0104 0.0635 0.0635
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0386 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0174 0.0555
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0055 0.0297 0.0297
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0037 0.0174 0.0174
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0058 0.032 0.0487
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0472 0.314 1
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Onchocerca volvulus Bile acid receptor homolog 0.0384 0.254 0.3883
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0165 0.0165
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Brugia malayi nuclear receptor RXR 0.0117 0.072 0.0734
Schistosoma mansoni thyroid hormone receptor 0.0221 0.1431 0.1431
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0063
Onchocerca volvulus 0.0104 0.0635 0.0968
Schistosoma mansoni hypothetical protein 0.0539 0.3597 0.3597
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0103 0.0327
Mycobacterium tuberculosis Conserved protein 0.0039 0.019 0.117
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0048 0.0048
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.164 0.1673
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0174 0.0174
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0013 0.0011 0.0011
Brugia malayi cathepsin F-like cysteine proteinase 0.0012 0.0003 0.0003
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0192 0.0196
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.1085 0.1085
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0026 0.0103 0.2744
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0221 0.1431 0.1459
Echinococcus multilocularis nAChR subunit 0.0013 0.0011 0.0011
Echinococcus multilocularis microtubule associated protein 2 0.1478 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Brugia malayi intermediate filament protein 0.0029 0.0124 0.0126
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0189 0.0189
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0001 0.0001
Entamoeba histolytica rodhanase-like domain containing protein 0.0058 0.032 0.8176
Onchocerca volvulus 0.0058 0.032 0.0487
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0048 0.0637
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0221 0.1431 0.1431
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0087
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Echinococcus granulosus dna polymerase kappa 0.0042 0.0211 0.0211
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Brugia malayi Nuclear hormone receptor E75 0.0104 0.0635 0.0647
Schistosoma mansoni cpg binding protein 0.0031 0.0136 0.0136
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0061 0.0341 0.0519
Brugia malayi nuclear hormone receptor 0.0221 0.1431 0.1459
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0037 0.0174 0.0178
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0001 0.0001
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.1085 0.1107
Trichomonas vaginalis cdc25b, putative 0.0058 0.032 0.0487
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0058 0.032 0.0487
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0122
Schistosoma mansoni polycystin 1-related 0.0061 0.0341 0.0341
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Entamoeba histolytica rodhanase-like domain containing protein 0.0058 0.032 0.8176
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0219 0.0332
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0386 0.0386
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.0635 0.0635
Schistosoma mansoni hypothetical protein 0.005 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus granulosus cathepsin l1 0.0035 0.0165 0.0165
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0026 0.0103 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0265 0.0265
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0221 0.1431 0.1431
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0189 0.0189
Onchocerca volvulus 0.0058 0.032 0.0487
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0255 0.0255
Plasmodium vivax hypothetical protein, conserved 0.0039 0.019 0.2469
Brugia malayi beta-lactamase family protein 0.0039 0.019 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0103 0.0327
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0268 0.0853
Leishmania major cysteine peptidase A (CPA) 0.0035 0.0165 0.0525
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0013 0.0011 0.0011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.019 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0221 0.1431 0.1431
Echinococcus multilocularis hypothetical protein 0.0037 0.0174 0.0174
Mycobacterium leprae Probable two-component sensor kinase 0.0026 0.0103 0.5383
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0283 0.0288
Trichomonas vaginalis cdc25b, putative 0.0058 0.032 0.0487
Onchocerca volvulus 0.0035 0.0165 0.025
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0341 0.0341
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Echinococcus granulosus RUN 0.0061 0.0341 0.0341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0092 0.0746
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0063 0.0063
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0189 0.0189
Entamoeba histolytica rodhanase-like domain containing protein 0.0058 0.032 0.8176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0048 0.0071
Onchocerca volvulus 0.0037 0.0174 0.0264
Brugia malayi ecdysteroid receptor 0.0384 0.254 0.259
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.1085 0.1085
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0026 0.0103 0.063
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0063 0.0094
Entamoeba histolytica hypothetical protein 0.0039 0.019 0.4583
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0011 0.0011
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0026 0.0103 0.0327
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0056 0.0304 0.031
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0025 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0085 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0085 0.1669
Loa Loa (eye worm) steroid hormone receptor 0.0221 0.1431 0.1459
Plasmodium vivax vivapain-2 0.0035 0.0165 0.2132
Mycobacterium ulcerans two component sensor kinase MprB 0.0026 0.0103 0.2744
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0063 0.0201
Onchocerca volvulus 0.0058 0.032 0.0487
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Brugia malayi conserved hypotetical protein 0.0104 0.0635 0.0647
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.0165 0.3992
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Schistosoma mansoni loxhd1 0.0061 0.0341 0.0341
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0344 0.0344
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0165 0.388
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0004 0.0004
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0219 0.0219
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0103 0.0327
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Brugia malayi PXA domain containing protein 0.0039 0.0189 0.0192
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0055 0.0297 0.0297
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0071 0.0227
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0211 0.0672
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Echinococcus multilocularis lamin 0.0029 0.0124 0.0124
Schistosoma mansoni rab6-interacting 0.0061 0.0341 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0374 0.0374
Brugia malayi tailless protein 0.0104 0.0635 0.0647
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0171 0.1092 0.1092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0761 0.0761
Echinococcus multilocularis lamin dm0 0.0029 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.019 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0026 0.0103 0.0155
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0268 0.0853
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0025 0.0025
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0219 0.0219
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0219 0.0223
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.019 0.0289
Toxoplasma gondii cathepsin CPL 0.0035 0.0165 0.1344
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0322 0.2121 0.2121
Schistosoma mansoni pyruvate dehydrogenase 0.0445 0.2961 0.2961
Loa Loa (eye worm) nuclear receptor NHR-67 0.0104 0.0635 0.0647
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.0635 0.0635
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0103 0.1308
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0013 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0843 0.2685
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0063 0.0063
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0092 0.7209
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0165 0.0168
Brugia malayi hypothetical protein 0.0039 0.019 0.0194
Loa Loa (eye worm) fibroinase 0.0035 0.0165 0.0168
Echinococcus multilocularis geminin 0.0539 0.3597 0.3597
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0001 0.001
Schistosoma mansoni heat shock protein 0.0026 0.0103 0.0103
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0364 0.2963
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0049 0.0255 0.026
Echinococcus granulosus protein tyrosine phosphatase n9 0.0037 0.0174 0.0174
Brugia malayi Nuclear hormone receptor-like 1 0.0221 0.1431 0.1459
Mycobacterium leprae Probable two component sensor kinase MprB 0.0026 0.0103 0.5383
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0386 0.1228
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0192 0.0192
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0088 0.0521 0.0531
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0037 0.0174 0.0178
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Toxoplasma gondii heat shock protein 90, putative 0.0026 0.0103 0.0836
Onchocerca volvulus 0.0039 0.019 0.0289
Echinococcus granulosus neuroligin 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0035 0.0165 0.025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0001 0.0001
Loa Loa (eye worm) beta-lactamase 0.0039 0.019 0.0194
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0386 0.0386
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus granulosus nAChR subunit 0.0013 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0068 0.0384 0.0392
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0017
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0026 0.0103 0.0105
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0013 0.0011 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0211 0.5649
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0117 0.072 0.0734
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0168
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.072 0.0734
Brugia malayi hypothetical protein 0.0039 0.0189 0.0192
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0026 0.0103 0.063
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Plasmodium vivax vivapain-1 0.0018 0.0048 0.0588
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.002 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0189 0.0189
Onchocerca volvulus 0.0221 0.1431 0.2186
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0103 0.0327
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0001 0.0009
Plasmodium falciparum endoplasmin, putative 0.0026 0.0103 0.1863
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0026 0.0103 0.063
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0843 0.2685
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0048 0.0153
Onchocerca volvulus 0.0013 0.0011 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0026 0.0103 0.063
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0063 0.0094
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Loa Loa (eye worm) TOPoisomerase family member 0.0026 0.0103 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Schistosoma mansoni nuclear receptor 0.0104 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Plasmodium falciparum DNA gyrase subunit B 0.0026 0.0103 0.1863
Schistosoma mansoni nuclear receptor 0.0104 0.0635 0.0635
Brugia malayi nuclear hormone receptor family member nhr-6 0.0104 0.0635 0.0647
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0058 0.032 0.0487
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0221 0.1431 0.1431
Onchocerca volvulus 0.0037 0.0174 0.0264
Schistosoma mansoni zinc finger protein 0.0104 0.0635 0.0635
Loa Loa (eye worm) cysteine protease 0.0035 0.0165 0.0168
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Trichomonas vaginalis set domain proteins, putative 0.097 0.6539 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0268 0.0408
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0344 0.0344
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0026 0.0103 0.0155
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0013 0.0011 0.0011
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Trypanosoma cruzi cruzipain precursor, putative 0.0012 0.0003 0.0011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Trypanosoma brucei protein kinase, putative 0.005 0.0268 0.0853
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0103 0.0836
Brugia malayi beta-lactamase family protein 0.0039 0.019 0.0194
Entamoeba histolytica hypothetical protein 0.0039 0.0189 0.454
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0103 0.0155
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0037 0.0174 0.0555
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0025 0.0025
Onchocerca volvulus 0.0123 0.0761 0.1162
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Mycobacterium ulcerans two component regulator - sensor kinase 0.0026 0.0103 0.2744
Schistosoma mansoni nuclear receptor nhr-48 0.0104 0.0635 0.0635
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.019 0.0607
Onchocerca volvulus 0.0037 0.0174 0.0264
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0063 0.0787
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.004 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0221 0.1431 0.1431
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0037 0.0174 0.0174
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.0165 0.3992
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0063
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0174 0.4135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0374 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0026 0.0103 0.2744
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0058 0.032 0.032
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0237 0.8476
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0219 0.0696
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0189 0.0189
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Schistosoma mansoni DNA topoisomerase II 0.0026 0.0103 0.0103
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0211 0.5649
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0092 0.0746
Brugia malayi Cation transporter family protein 0.0013 0.0011 0.0011
Brugia malayi Protein-tyrosine phosphatase 1 0.0037 0.0174 0.0178
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0026 0.0103 0.0103
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0048 0.0153
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0189 0.0189
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0048 0.0637
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0221 0.1431 0.1431
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0384 0.0392
Leishmania major hypothetical protein, conserved 0.0026 0.0103 0.0327
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0123 0.0763 0.2431
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0048 0.0153
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0521 0.0531
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0189 0.0189
Brugia malayi Probable DNA topoisomerase II 0.0026 0.0103 0.0105
Brugia malayi hypothetical protein 0.0117 0.072 0.0734
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0039 0.0189 0.454
Brugia malayi Cathepsin L-like precursor 0.0024 0.0085 0.0087
Schistosoma mansoni steroid hormone receptor ad4bp 0.0221 0.1431 0.1431
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) ctsf protein 0.0035 0.0165 0.0168
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0386 0.0393
Onchocerca volvulus 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0026 0.0103 0.2744
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.019 0.5098
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.019 0.019
Trichomonas vaginalis sensor histidine kinase, putative 0.0026 0.0103 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0117 0.072 0.072
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0117 0.072 0.072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0221 0.1431 0.1459
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0374 1
Plasmodium vivax vivapain-3 0.0018 0.0048 0.0588
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0026 0.0103 0.2744
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0384 0.0384
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Toxoplasma gondii DNA topoisomerase 2, putative 0.0026 0.0103 0.0836
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0103 0.0327
Echinococcus multilocularis Polycystic kidney disease protein 0.0061 0.0341 0.0341
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0189 0.0189
Echinococcus granulosus lamin dm0 0.0029 0.0124 0.0124
Loa Loa (eye worm) nuclear hormone receptor 0.0104 0.0635 0.0647
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0092 0.0291
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0374 0.0374
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0026 0.0103 0.5383
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0001 0.0001
Brugia malayi Cation transporter family protein 0.0013 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Schistosoma mansoni pyruvate dehydrogenase 0.0445 0.2961 0.2961
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0054 0.0289 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0048 0.0153
Onchocerca volvulus 0.0035 0.0165 0.025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0016 0.0016
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0165 0.1048 0.3338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Giardia lamblia Pms1-like protein 0.0026 0.0103 0.1929
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0384 0.0384
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0063 0.0387
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0026 0.0103 0.063
Toxoplasma gondii heat shock protein HSP90 0.0026 0.0103 0.0836
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0001 0.0001
Echinococcus granulosus cathepsin L 0.0018 0.0048 0.0048
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0013 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0219 0.0219
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0026 0.0103 0.0155
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0031 0.0031
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0048 0.0637
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0174 0.0178
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0055 0.0297 0.0303
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0221 0.1431 0.1459
Echinococcus multilocularis neuroligin 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Leishmania major DNA polymerase kappa, putative 0.0022 0.0071 0.0227
Trypanosoma brucei DNA topoisomerase ii 0.0026 0.0103 0.0327
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0221 0.1431 0.1431
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0374 0.2295
Toxoplasma gondii ABC1 family protein 0.0039 0.019 0.1552
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0026 0.0103 0.063
Onchocerca volvulus 0.0029 0.0124 0.0187
Mycobacterium tuberculosis Probable two component sensor kinase 0.0026 0.0103 0.063
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0048 0.0049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0221 0.1431 0.1459
Loa Loa (eye worm) hypothetical protein 0.0061 0.0341 0.0348
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0268 0.2184
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0092 0.2449
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Trypanosoma cruzi Heat shock protein 83, putative 0.0026 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0017
Schistosoma mansoni lamin 0.0029 0.0124 0.0124
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0165 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0221 0.1431 0.1459
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0374 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0243 0.1579 0.1611
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0001 0.0001
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0037 0.0174 0.0178
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0048 0.0637
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Leishmania major cathepsin L-like protease 0.0135 0.0843 0.2685
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0026 0.0103 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0221 0.1431 0.1431
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0103 0.0327
Onchocerca volvulus 0.0088 0.0521 0.0794
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.0761 0.0761
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.0165 0.0165
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0341 0.0341
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0025 0.0025
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0026 0.0103 0.063
Entamoeba histolytica hypothetical protein 0.0039 0.019 0.4583
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0103 0.2151
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.0761 0.6203
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1449 0.9804 0.9804
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0219 0.0332
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0221 0.1431 0.1431
Trypanosoma brucei Heat shock protein 83, putative 0.0026 0.0103 0.0327
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0103 1
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus nuclear receptor nhr 48 0.0104 0.0635 0.0635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0085 0.0128
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0058 0.032 0.0487
Loa Loa (eye worm) carboxylesterase 0.0011 0.0001 0.0001
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0011 0.0011
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0103 0.0155
Brugia malayi nuclear receptor NHR-88 0.0104 0.0635 0.0647
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0221 0.1431 0.1459
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0048 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0068 0.0384 0.0392
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0124 0.0126
Echinococcus granulosus intermediate filament protein 0.0029 0.0124 0.0124
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.019 0.0289
Schistosoma mansoni rab6-interacting 0.0061 0.0341 0.0341
Schistosoma mansoni hypothetical protein 0.0039 0.019 0.019
Onchocerca volvulus 0.0037 0.0174 0.0264
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0268 0.0408
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0189 0.0192
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.019 0.0607
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0001 0.0009
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Brugia malayi Carboxylesterase family protein 0.0068 0.0384 0.0392
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0025
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0037 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0048 0.0637
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0071 0.0437
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0219 0.7593
Entamoeba histolytica hypothetical protein 0.0039 0.019 0.4583
Brugia malayi nuclear receptor NHR-88 0.0221 0.1431 0.1459
Echinococcus multilocularis RUN 0.0061 0.0341 0.0341
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0268 1
Onchocerca volvulus 0.0037 0.0174 0.0264
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.019 0.0289
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0219 0.0332
Echinococcus granulosus cysteine protease 0.0018 0.0048 0.0048
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0646 0.2058
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0521 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0013 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.0135 0.0843 0.2685
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0103 0.0327
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.0635 0.0968
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0189 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0221 0.1431 0.1459
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Echinococcus granulosus dnaJ subfamily B 0.042 0.2787 0.2787
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0025 0.0153
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0221 0.1431 0.1431
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0104 0.0635 0.0635
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Onchocerca volvulus 0.0037 0.0174 0.0264
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0048 0.0153
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Brugia malayi Doublecortin family protein 0.0061 0.0341 0.0348
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.019 0.0194

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 20 % Growth inhibition of Staphylococcus aureus ATCC 25923 at 0.1 mg/ml after 24 hrs ChEMBL. 18086525
Inhibition (functional) = 40 % Growth inhibition of Staphylococcus aureus 1199B expressing NorA at 0.1 mg/ml after 24 hrs ChEMBL. 18086525
Inhibition (functional) = 43 % Growth inhibition of Staphylococcus aureus RN4220 expressing MsrA at 0.1 mg/ml after 24 hrs ChEMBL. 18086525
Inhibition (functional) = 45 % Growth inhibition of Staphylococcus aureus 1199B expressing NorA at 0.1 mg/ml after 24 hrs in presence of 4 mg/L ciprofloxacin ChEMBL. 18086525
Inhibition (functional) = 65 % Growth inhibition of Staphylococcus aureus RN4220 expressing MsrA at 0.1 mg/ml after 24 hrs in presence of 16 mg/L erythromycin ChEMBL. 18086525

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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