Detailed information for compound 519510

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.423 | Formula: C20H25FN2O2
  • H donors: 0 H acceptors: 0 LogP: 3.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCCOc1ccc(cc1)CN1CCN(CC1)c1ccccc1OC
  • InChi: 1S/C20H25FN2O2/c1-24-20-5-3-2-4-19(20)23-13-11-22(12-14-23)16-17-6-8-18(9-7-17)25-15-10-21/h2-9H,10-16H2,1H3
  • InChiKey: RLXWQKHLDFBDJH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Serotonin 2a (5-HT2a) receptor Starlite/ChEMBL References
Sus scrofa Dopamine D1 receptor Starlite/ChEMBL References
Homo sapiens dopamine receptor D4 Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Echinococcus granulosus g protein coupled receptor Serotonin 2a (5-HT2a) receptor   470 aa 403 aa 20.8 %
Echinococcus granulosus g protein coupled receptor Serotonin 2a (5-HT2a) receptor   470 aa 416 aa 20.4 %
Echinococcus multilocularis g protein coupled receptor Serotonin 2a (5-HT2a) receptor   470 aa 416 aa 20.4 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Serotonin 2a (5-HT2a) receptor   470 aa 386 aa 22.8 %
Echinococcus multilocularis g protein coupled receptor Serotonin 2a (5-HT2a) receptor   470 aa 471 aa 20.8 %
Onchocerca volvulus Dopamine D1 receptor   446 aa 357 aa 21.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine D1 receptor   446 aa 406 aa 33.7 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   446 aa 370 aa 24.3 %
Echinococcus granulosus orexin receptor type 2 Serotonin 2a (5-HT2a) receptor   470 aa 379 aa 20.1 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 2a (5-HT2a) receptor   470 aa 422 aa 28.0 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 2a (5-HT2a) receptor   470 aa 411 aa 25.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D1 receptor   446 aa 373 aa 27.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0013 0.0012
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0145 0.1699 0.2676
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0684 0.0683
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Brugia malayi Bromodomain containing protein 0.0084 0.0897 0.1412
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0081 0.008
Brugia malayi jmjC domain containing protein 0.0028 0.0154 0.024
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Echinococcus granulosus single minded 2 0.0083 0.0881 0.0879
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0081 0.008
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0283 0.0443
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0105 0.1169 0.1841
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0013 0.0012
Onchocerca volvulus 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0103 0.1146 0.1144
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.064 0.1006
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.016 0.1902 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0013 0.0012
Brugia malayi jmjC domain containing protein 0.0168 0.2009 0.3165
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) intermediate filament protein 0.003 0.0188 0.0294
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0013 0.0012
Onchocerca volvulus 0.0017 0.0013 0.0018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0013 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0322 0.0332
Brugia malayi Pre-SET motif family protein 0.0066 0.0653 0.1026
Leishmania major pyruvate kinase 0.0037 0.0283 0.155
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0081 0.0126
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0497 0.6343 1
Brugia malayi PHD-finger family protein 0.0031 0.0201 0.0314
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0013 0.0012
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0154 0.0783
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0081 0.008
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0042 0.0433
Brugia malayi jmjC domain containing protein 0.0108 0.1213 0.191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0435 0.0434
Brugia malayi hypothetical protein 0.0065 0.0651 0.1024
Schistosoma mansoni rab6-interacting 0.0065 0.0651 0.065
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0012
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0012
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0081 0.0126
Schistosoma mansoni biogenic amine receptor 0.0017 0.0013 0.0012
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0145 0.1699 0.1697
Echinococcus multilocularis peregrin 0.0036 0.027 0.0268
Loa Loa (eye worm) prolyl 4-hydroxylase 2 0.0023 0.0091 0.0141
Echinococcus granulosus prolyl 4 hydroxylase subunit alpha 1 0.0023 0.0091 0.0089
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0154 0.0152
Onchocerca volvulus 0.0023 0.0091 0.0134
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0154 0.024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0141
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0013 0.0012
Echinococcus multilocularis Protein lozenge 0.0062 0.0611 0.061
Schistosoma mansoni single-minded 0.0107 0.1196 0.1195
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0145 0.1699 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0283 0.0443
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0154 0.1458
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0013 0.0018
Brugia malayi Pre-SET motif family protein 0.0457 0.581 0.9159
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0684 0.1076
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0013 0.0012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0081 0.008
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0013 0.0012
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0328 0.4114 1
Schistosoma mansoni lozenge 0.0062 0.0611 0.061
Schistosoma mansoni hypothetical protein 0.0636 0.8177 0.8177
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0322 0.0943
Echinococcus granulosus sex peptide receptor 0.0017 0.0013 0.0012
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0013 0.0018
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0013 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0147 0.1731 0.173
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.3131 0.313
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0321 0.4018 0.4017
Brugia malayi beta-lactamase family protein 0.004 0.0322 0.0505
Mycobacterium ulcerans hypothetical protein 0.004 0.0322 0.1292
Chlamydia trachomatis pyruvate kinase 0.0037 0.0283 0.203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0435 0.0434
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0283 0.0443
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Plasmodium falciparum phd finger protein, putative 0.0031 0.0201 0.1979
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0435 0.0684
Loa Loa (eye worm) jmjC domain-containing protein 0.0108 0.1213 0.191
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0154 0.0152
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0013 0.0018
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0081 0.0126
Schistosoma mansoni aryl hydrocarbon receptor 0.0107 0.1196 0.1195
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0154 0.0152
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0042 0.0217
Brugia malayi nuclear receptor NHR-88 0.0022 0.0081 0.0126
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0012
Echinococcus multilocularis pyruvate kinase 0.0019 0.0042 0.0041
Leishmania major hypothetical protein, conserved 0.0023 0.0091 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0283 0.0272
Echinococcus multilocularis transcription factor Dp 1 0.0084 0.0894 0.0893
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Echinococcus multilocularis Ankyrin 0.0016 0.0004 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0322 0.0332
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0119 0.0577
Schistosoma mansoni zinc finger protein 0.0034 0.0232 0.023
Loa Loa (eye worm) MBCTL1 0.0119 0.136 0.2142
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0013 0.0012
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0081 0.008
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0277 0.3448 0.3446
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0013 0.0012
Brugia malayi mbt repeat family protein 0.0105 0.1169 0.1841
Leishmania major hypothetical protein, conserved 0.004 0.0322 0.1784
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0013 0.0018
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0004 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0651 0.065
Schistosoma mansoni pyruvate kinase 0.0037 0.0283 0.0281
Brugia malayi neuropeptide F receptor 0.0017 0.0013 0.0018
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0013 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0314
Onchocerca volvulus 0.0022 0.0081 0.012
Brugia malayi Dopamine receptor protein 1 0.0017 0.0013 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0621 0.0619
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0013 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0081 0.008
Brugia malayi ORL1-like opioid receptor 0.0017 0.0013 0.0018
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.0879 0.0877
Echinococcus granulosus somatostatin receptor 0.0017 0.0013 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0322 0.032
Echinococcus multilocularis zinc finger protein 0.0043 0.0355 0.0354
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0086 0.0923 0.4607
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0322 0.032
Echinococcus multilocularis SAM and MBT domain containing protein 0.0105 0.1169 0.1167
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0012
Onchocerca volvulus 0.0017 0.0013 0.0018
Echinococcus granulosus pyruvate kinase 0.0019 0.0042 0.0041
Onchocerca volvulus 0.0053 0.0489 0.0734
Onchocerca volvulus 0.0028 0.0155 0.023
Echinococcus granulosus g protein coupled receptor 0.0017 0.0013 0.0012
Brugia malayi sulfakinin receptor protein 0.0017 0.0013 0.0018
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0964 0.0962
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0154 0.0152
Echinococcus granulosus RUN 0.0065 0.0651 0.065
Brugia malayi steroid hormone receptor 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0086 0.0923 0.1453
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0688 0.3308
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0471 0.0739
Onchocerca volvulus 0.0017 0.0013 0.0018
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.3131 0.313
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0154 0.0152
Schistosoma mansoni intermediate filament proteins 0.003 0.0188 0.0186
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0188 0.0294
Loa Loa (eye worm) hypothetical protein 0.0358 0.451 0.711
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0081 0.008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0087 0.0203
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0013 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0283 0.0423
Onchocerca volvulus 0.0017 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0065 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.0065 0.0651 0.1024
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0013 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0154 0.024
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0012
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0155 0.0076
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0013 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0012
Brugia malayi AKH receptor 0.0017 0.0013 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0081 0.008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0081 0.008
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0119 0.0305
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0651 0.065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0653 0.0651
Echinococcus granulosus polycomb protein SCMH1 0.0105 0.1169 0.1167
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0133 0.0207
Plasmodium falciparum LCCL domain-containing protein 0.0065 0.0651 0.6979
Brugia malayi hypoxia-induced factor 1 0.033 0.4145 0.6533
Onchocerca volvulus 0.0066 0.0653 0.098
Leishmania major hypothetical protein, unknown function 0.0023 0.0091 0.0407
Echinococcus granulosus lamin dm0 0.003 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Brugia malayi PAS domain containing protein 0.0107 0.1196 0.1884
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0013 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0322 0.1784
Onchocerca volvulus 0.0053 0.0489 0.0734
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0362 0.0361
Onchocerca volvulus 0.0017 0.0013 0.0018
Echinococcus granulosus peregrin 0.0036 0.027 0.0268
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0335 0.0333
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.0828 0.0827
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0145 0.1699 0.2676
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0023 0.0091 0.0986
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0385 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Toxoplasma gondii hypoxia- inducible factor prolyl hydroxylase (phd2), putative 0.0023 0.0091 0.0986
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0013 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0012
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0013 0.0018
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0154 0.0783
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0013 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0653 0.0651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0081 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0155 0.0076
Trypanosoma brucei 2OG-Fe(II) oxygenase superfamily, putative 0.0023 0.0091 0.0407
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0201 0.0199
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0119 0.0577
Brugia malayi putative neuropeptide receptor 0.0017 0.0013 0.0018
Leishmania major protein kinase, putative 0.0028 0.0155 0.0787
Onchocerca volvulus 0.0065 0.0651 0.0978
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0135
Brugia malayi Doublecortin family protein 0.0065 0.0651 0.1024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0335 0.0525
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0283 0.0443
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0154 0.0152
Echinococcus granulosus tar DNA binding protein 0.0068 0.0684 0.0683
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0154 0.0152
Onchocerca volvulus 0.004 0.0322 0.0482
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0283 0.155
Onchocerca volvulus 0.0017 0.0013 0.0018
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0002 0.000000048515
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0013 0.0012
Echinococcus granulosus lamin 0.003 0.0188 0.0186
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0013 0.0012
Echinococcus granulosus fmrfamide receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0081 0.0126
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0168 0.2009 0.2007
Schistosoma mansoni prolyl 4-hydroxylase alpha subunit 1 0.0023 0.0091 0.0089
Plasmodium falciparum pyruvate kinase 0.0037 0.0283 0.2886
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0021
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0322 0.0943
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0322 0.0505
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0299 0.0297
Schistosoma mansoni zinc finger protein 0.0043 0.0355 0.0354
Echinococcus granulosus histone acetyltransferase MYST2 0.0119 0.136 0.1358
Echinococcus granulosus pyruvate kinase 0.0037 0.0283 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0155 0.0241
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0154 0.0152
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0964 0.0962
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0435 0.0434
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0321 0.4018 0.4017
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0021
Schistosoma mansoni sex comb on midleg homolog 0.0105 0.1169 0.1167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0923 1
Schistosoma mansoni lipoxygenase 0.0321 0.4018 0.4017
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0168 0.2009 0.2007
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0028 0.0155 0.0153
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0086 0.0923 0.284
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0081 0.0126
Mycobacterium leprae Probable lipase LipE 0.004 0.0322 0.1292
Schistosoma mansoni opsin-like receptor 0.0017 0.0013 0.0012
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0013 0.0012
Brugia malayi hypothetical protein 0.0131 0.152 0.2395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.4114 0.6133
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0013 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0684 0.0683
Mycobacterium tuberculosis Conserved protein 0.004 0.0322 0.0943
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0119 0.1294
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0038 0.0037
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0012
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0684 0.1076
Echinococcus multilocularis serotonin receptor 0.0017 0.0013 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.0412
Brugia malayi jmjC domain containing protein 0.0028 0.0154 0.024
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0013 0.0012
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0086 0.0923 0.1453
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0154 0.1669
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0003
Schistosoma mansoni sex comb on midleg homolog 0.0105 0.1169 0.1167
Echinococcus multilocularis Polycystic kidney disease protein 0.0065 0.0651 0.065
Loa Loa (eye worm) mbt repeat family protein 0.0105 0.1169 0.1841
Plasmodium vivax JmjC domain containing protein 0.0028 0.0154 0.1646
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Brugia malayi RE15519p 0.0017 0.0013 0.0018
Giardia lamblia PHD finger protein 15 0.0031 0.0201 0.039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0155 0.0076
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0028 0.0155 0.0241
Schistosoma mansoni pyruvate kinase 0.0037 0.0283 0.0281
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0013 0.0012
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0028 0.0155 0.0076
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0013 0.0012
Onchocerca volvulus 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0037 0.0283 0.0443
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0335 0.0525
Brugia malayi jmjC domain containing protein 0.0028 0.0154 0.024
Brugia malayi DOMON domain containing protein 0.0053 0.0489 0.0769
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0283 0.0423
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0155 0.0076
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0964 0.1517
Mycobacterium tuberculosis Conserved protein 0.004 0.0322 0.0943
Schistosoma mansoni polycystin 1-related 0.0065 0.0651 0.065
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0023 0.0021
Trypanosoma cruzi ISWI complex protein 0.0034 0.0232 0.1246
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0013 0.0012
Trypanosoma brucei ISWI complex protein 0.0034 0.0232 0.1246
Onchocerca volvulus 0.0017 0.0013 0.0018
Echinococcus granulosus Polycystic kidney disease protein 0.0065 0.0651 0.065
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0688 0.3966
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0013 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0684 0.0683
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Brugia malayi prolyl 4-hydroxylase 0.0023 0.0091 0.0141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Treponema pallidum fructose-bisphosphate aldolase 0.0328 0.4114 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0155 0.0787
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Onchocerca volvulus 0.0017 0.0013 0.0018
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0042 0.0459
Echinococcus multilocularis pyruvate kinase 0.0037 0.0283 0.0281
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Schistosoma mansoni peptidylglycine monooxygenase 0.0277 0.3448 0.3446
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Onchocerca volvulus Alhambra homolog 0.0031 0.0201 0.03
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0282 0.0281
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0028 0.0155 0.0076
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0011 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0322 0.0943
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0209 0.0208
Echinococcus granulosus g protein coupled receptor 0.0017 0.0013 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0688 0.0686
Plasmodium vivax multidomain scavenger receptor, putative 0.0065 0.0651 0.7045
Echinococcus multilocularis transfer RNA-Lys 0.0079 0.0831 0.0829
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0003 0.0002
Onchocerca volvulus 0.0017 0.0013 0.0018
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0002 0.000000048515
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0087 0.0135
Brugia malayi DOMON domain containing protein 0.0053 0.0489 0.0769
Onchocerca volvulus 0.0105 0.1169 0.1757
Onchocerca volvulus 0.0017 0.0013 0.0018
Brugia malayi PHD-finger family protein 0.0055 0.051 0.0801
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0081 0.008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0021
Onchocerca volvulus 0.0017 0.0013 0.0018
Brugia malayi hypothetical protein 0.0358 0.451 0.711
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0013 0.0012
Toxoplasma gondii ABC1 family protein 0.004 0.0322 0.3486
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0013 0.0012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0688 0.0686
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus granulosus bloom syndrome protein 0.0024 0.0105 0.0103
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0023 0.0021
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0154 0.0152
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0081 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0012
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0283 0.155
Schistosoma mansoni hypothetical protein 0.0031 0.0201 0.0199
Brugia malayi intermediate filament protein 0.003 0.0188 0.0294
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0441 0.0439
Brugia malayi Melatonin receptor type 1A 0.0017 0.0013 0.0018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0013 0.0012
Brugia malayi hypothetical protein 0.0497 0.6343 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus granulosus transcription factor Dp 1 0.0084 0.0894 0.0893
Schistosoma mansoni hypothetical protein 0.0034 0.0232 0.023
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0201 0.0314
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0119 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0154 0.024
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0081 0.008
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0119 0.1294
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0012
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0012
Onchocerca volvulus 0.0017 0.0013 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0688 0.0686
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) beta-lactamase 0.004 0.0322 0.0505
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0013 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0322 0.1292
Schistosoma mansoni hypothetical protein 0.0052 0.0471 0.0469
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0013 0.0012
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0145 0.1699 1
Echinococcus granulosus intermediate filament protein 0.003 0.0188 0.0186
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0155 0.0076
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0013 0.0012
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0023 0.0091 0.0407
Brugia malayi Bromodomain containing protein 0.0165 0.1959 0.3086
Brugia malayi Serotonin receptor 0.0017 0.0013 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0684 0.0683
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0322 0.0943
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0081 0.0126
Mycobacterium ulcerans putative regulatory protein 0.0079 0.0831 0.4097
Echinococcus multilocularis prolyl 4 hydroxylase subunit alpha 1 0.0023 0.0091 0.0089
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0277 0.3448 0.5434
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0283 0.3062
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0119 0.0177
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0023 0.0247
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.0879 0.0877
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0105 0.0103
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0145 0.1699 1
Echinococcus granulosus g protein coupled receptor 0.0017 0.0013 0.0012
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.4114 0.6133
Mycobacterium ulcerans lipase LipD 0.004 0.0322 0.1292
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Schistosoma mansoni myosin xvIII 0.0017 0.0013 0.0012
Echinococcus granulosus orexin receptor type 2 0.0017 0.0013 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0013 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0684 0.0683
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0081 0.008
Onchocerca volvulus 0.004 0.0322 0.0482
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.1516 0.1515
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0013 0.0018
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0013 0.0012
Leishmania major pyruvate kinase 0.0037 0.0283 0.155
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0322 0.032
Onchocerca volvulus 0.0017 0.0013 0.0018
Schistosoma mansoni lamin 0.003 0.0188 0.0186
Leishmania major hypothetical protein, conserved 0.0034 0.0232 0.1246
Loa Loa (eye worm) hypothetical protein 0.0089 0.0968 0.1523
Brugia malayi Protein kinase domain containing protein 0.0016 0.0002 0.000000076493
Brugia malayi mbt repeat family protein 0.0105 0.1169 0.1841
Echinococcus granulosus pyruvate kinase 0.0019 0.0042 0.0041
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0013 0.0012
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0105 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0081 0.008
Echinococcus granulosus geminin 0.0372 0.4691 0.469
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0013 0.0012
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0322 0.0943
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.3193 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0105 0.1169 0.1167
Echinococcus multilocularis geminin 0.0372 0.4691 0.469
Schistosoma mansoni biogenic amine receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0081 0.0126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0322 0.0943
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0283 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0081 0.0126
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0013 0.0012
Leishmania major hypothetical protein, conserved 0.0028 0.0154 0.0783
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0412 0.5227 0.5226
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0435 0.0434
Loa Loa (eye worm) doublecortin family protein 0.0065 0.0651 0.1024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0435 0.0434
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0201 0.2156
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0013 0.0012
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0012
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0013 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0013 0.0012
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0155 0.0787
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0081 0.008
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0155 0.0787
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0137 0.1591 0.2506
Echinococcus multilocularis sex peptide receptor 0.0017 0.0013 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.0775 1 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.3131 0.4934
Brugia malayi neuropeptide F receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.0282
Plasmodium vivax hypothetical protein, conserved 0.004 0.0322 0.3468
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0322 0.1292
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0013 0.0012
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0013 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0081 0.0126
Echinococcus multilocularis serotonin receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0155 0.0076
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0145 0.1699 1
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0013 0.0012
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0155 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0012
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0188 0.0294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0081 0.0126
Schistosoma mansoni survival motor neuron protein 0.0052 0.0471 0.0469
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0081 0.0126
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0283 0.155
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0277 0.3448 0.3446
Echinococcus multilocularis pyruvate kinase 0.0019 0.0042 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.4114 0.6133
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0154 0.1669
Schistosoma mansoni jumonji/arid domain-containing protein 0.0108 0.1213 0.1212
Echinococcus granulosus histone lysine methyltransferase setb 0.0103 0.1146 0.1144
Brugia malayi Serotonin receptor 0.0017 0.0013 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0108 0.1213 0.1212
Chlamydia trachomatis endonuclease IV 0.0086 0.0923 1
Trypanosoma cruzi ISWI complex protein 0.0034 0.0232 0.1246
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0201 0.0199
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0028 0.0155 0.0439
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0013 0.0012
Mycobacterium ulcerans beta-lactamase 0.004 0.0322 0.1292
Brugia malayi beta-lactamase 0.004 0.0322 0.0505
Echinococcus granulosus phd:f box containing protein 0.0028 0.0154 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0155 0.0076
Schistosoma mansoni biogenic amine receptor 0.0017 0.0013 0.0012
Onchocerca volvulus 0.0017 0.0013 0.0018
Loa Loa (eye worm) runx1 0.0062 0.0611 0.0961
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0322 0.1784
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0441 0.0439
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0081 0.012
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0081 0.008
Echinococcus granulosus pyruvate kinase 0.0019 0.0042 0.0041
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0013 0.0012
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0013 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0062
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0066 0.0484
Brugia malayi ecdysteroid receptor 0.0022 0.0081 0.0126
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0013 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0081 0.0126
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0282 0.0281
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0013 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.4114 0.6133
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0013 0.0012
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0013 0.0012
Echinococcus granulosus neuropeptide receptor 0.0017 0.0013 0.0012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0081 0.008
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0322 0.0332
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0013 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0435 0.0684
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0012
Onchocerca volvulus 0.0497 0.6343 0.9548
Echinococcus multilocularis RUN 0.0065 0.0651 0.065
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0081 0.008
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0362 0.0361
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0023 0.0247
Onchocerca volvulus 0.0052 0.0471 0.0706
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0013 0.0018
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0923 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0087 0.0129
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0283 0.0443
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0154 0.024
Echinococcus granulosus allatostatin A receptor 0.0017 0.0013 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0435 0.0434
Echinococcus granulosus aryl hydrocarbon receptor 0.0028 0.0155 0.0153
Loa Loa (eye worm) hypothetical protein 0.0071 0.0727 0.1144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0081 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.4114 0.6133
Echinococcus multilocularis somatostatin receptor 0.0017 0.0013 0.0012
Brugia malayi beta-lactamase family protein 0.004 0.0322 0.0505
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0103 0.1146 0.1144
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0322 0.0332
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0013 0.0018
Echinococcus multilocularis pyruvate kinase 0.0019 0.0042 0.0041
Brugia malayi hypothetical protein 0.0253 0.3131 0.4934
Echinococcus multilocularis pyruvate kinase 0.003 0.0179 0.0177
Loa Loa (eye worm) hypothetical protein 0.0065 0.0651 0.1024
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0154 0.0783
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0081 0.008
Onchocerca volvulus Huntingtin homolog 0.0131 0.152 0.2286
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0023 0.022
Echinococcus multilocularis microtubule associated protein 2 0.0775 1 1
Echinococcus granulosus hypothetical protein 0.0017 0.0013 0.0012
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0154 0.0152
Brugia malayi Bromodomain containing protein 0.0036 0.027 0.0422
Loa Loa (eye worm) hypothetical protein 0.0084 0.0899 0.1415
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0154 0.024
Echinococcus multilocularis polycomb protein SCMH1 0.0105 0.1169 0.1167
Loa Loa (eye worm) hypothetical protein 0.0277 0.3448 0.5434
Brugia malayi nuclear hormone receptor 0.0022 0.0081 0.0126
Onchocerca volvulus 0.0065 0.0651 0.0978
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0322 0.032
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Echinococcus granulosus zinc finger protein 0.0043 0.0355 0.0354
Brugia malayi DOMON domain containing protein 0.0053 0.0489 0.0769
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0277 0.3448 0.3446
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0299 0.0297
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0013 0.0012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0023 0.0021
Onchocerca volvulus 0.0089 0.0964 0.1449
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0688 0.3308
Brugia malayi Dopamine receptor protein 2 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0131 0.152 0.2395
Schistosoma mansoni hypothetical protein 0.0372 0.4691 0.469
Loa Loa (eye worm) hypothetical protein 0.0497 0.6343 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0119 0.136 0.1358
Brugia malayi G-protein coupled receptor 0.0017 0.0013 0.0018
Echinococcus granulosus lysine specific demethylase 5A 0.0108 0.1213 0.1212
Loa Loa (eye worm) RecQ helicase 0.0024 0.0105 0.0162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Trichomonas vaginalis esterase, putative 0.004 0.0322 0.0332
Loa Loa (eye worm) DOMON domain-containing protein 0.0053 0.0489 0.0769
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0012
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0145 0.1699 0.1697
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0013 0.0012
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0283 0.1077
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0684 0.1076
Schistosoma mansoni bromodomain containing protein 0.0139 0.162 0.1618
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0277 0.3448 0.5434
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0081 0.012
Schistosoma mansoni loxhd1 0.0065 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.0103 0.1146 0.1804
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0023 0.0091 0.0986
Onchocerca volvulus 0.003 0.0188 0.0281
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0335 0.0333
Brugia malayi TAR-binding protein 0.0068 0.0684 0.1076
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0013 0.0012
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0119 0.136 0.1358
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0013 0.0012
Plasmodium vivax SET domain protein, putative 0.0066 0.0653 0.7061
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0013 0.0012
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0105 0.1169 0.1757
Mycobacterium tuberculosis Conserved protein 0.004 0.0322 0.0943
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Toxoplasma gondii endonuclease IV APN 0.0086 0.0923 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0013 0.0012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0013 0.0012
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0283 0.1077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0103 0.1146 0.1144
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0283 0.0423
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0385 0.0383
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0386 0.0606
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0013 0.0018
Giardia lamblia Pyruvate kinase 0.0037 0.0283 0.059
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0651 0.065
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0013 0.0012
Schistosoma mansoni pyruvate kinase 0.0019 0.0042 0.0041
Schistosoma mansoni rab6-interacting 0.0065 0.0651 0.065
Loa Loa (eye worm) RNA binding protein 0.0068 0.0684 0.1076
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0282 0.0281
Loa Loa (eye worm) hypothetical protein 0.0089 0.0964 0.1517
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0322 0.0943
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0155 0.0787
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0653 0.0651
Schistosoma mansoni opsin-like receptor 0.0017 0.0013 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0688 0.7447
Loa Loa (eye worm) hypothetical protein 0.0119 0.136 0.2142
Echinococcus granulosus neuropeptide receptor 0.0017 0.0013 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0012
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0277 0.3448 0.5434
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0119 0.136 0.2142
Echinococcus multilocularis musashi 0.003 0.0188 0.0186
Brugia malayi hypothetical protein 0.0065 0.0651 0.1024
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0282 0.0281
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0964 0.0962
Echinococcus granulosus pyruvate kinase 0.0037 0.0283 0.0281
Loa Loa (eye worm) hypothetical protein 0.0131 0.152 0.2395
Echinococcus multilocularis histone acetyltransferase MYST2 0.0119 0.136 0.1358
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.4114 0.6133
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0457 0.581 0.9159
Leishmania major protein kinase, putative 0.0033 0.0227 0.1218
Onchocerca volvulus 0.004 0.0322 0.0482
Onchocerca volvulus Huntingtin homolog 0.0131 0.152 0.2286
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0012
Brugia malayi Death domain containing protein 0.0016 0.0002 0.000000076493
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0201 0.2178
Brugia malayi jmjC domain containing protein 0.0028 0.0154 0.024
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Echinococcus multilocularis lamin 0.003 0.0188 0.0186
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0013 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0081 0.008
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0154 0.0152
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0684 0.0683
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0081 0.012
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0002 0.000000048515
Brugia malayi RNA binding protein 0.0068 0.0684 0.1076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0283 0.3042
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0145 0.1699 0.3954
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.016 0.1902 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.0828 0.0827
Brugia malayi Uncoordinated protein 44 0.0016 0.0002 0.000000076493
Brugia malayi isocitrate dehydrogenase 0.0018 0.0023 0.0033
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0119 0.1074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0688 0.3308
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0081 0.0126
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0013 0.0012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0081 0.008
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0412 0.5227 0.5226
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0013 0.0012
Onchocerca volvulus 0.0079 0.0831 0.1248
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0081 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Schistosoma mansoni histamine h1 receptor 0.0017 0.0013 0.0012
Schistosoma mansoni coup transcription factor 0.0022 0.0081 0.008
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0013 0.0012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0322 0.0505
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0133 0.0035
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.1516 0.1515
Onchocerca volvulus 0.052 0.6643 1
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0012
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0023 0.0091 0.0407
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0126
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0003 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Echinococcus multilocularis aryl hydrocarbon receptor 0.0028 0.0155 0.0153
Brugia malayi G-protein coupled receptor 0.0017 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0045 0.0386 0.0384
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0119 0.127
Schistosoma mansoni lamin 0.003 0.0188 0.0186
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0013 0.0018
Echinococcus multilocularis pyruvate kinase 0.0037 0.0283 0.0281
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0207
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0209 0.0208
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0201 0.0199
Brugia malayi Dopamine receptor 0.0017 0.0013 0.0018
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0653 0.7069
Giardia lamblia Fructose-bisphosphate aldolase 0.0328 0.4114 1
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypoxia-induced factor 1 0.033 0.4145 0.6533
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0322 0.0332
Echinococcus multilocularis lysine specific demethylase 5A 0.0104 0.1158 0.1156
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0119 0.0177
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0145 0.1699 0.1697
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0105 0.1169 0.1167
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.03 0.047
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0201 0.2178
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0081 0.0126
Loa Loa (eye worm) hypothetical protein 0.0155 0.1835 0.2891
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0155 0.0076
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0013 0.0018
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0155 0.0787
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0012
Brugia malayi GnHR receptor homolog 0.0017 0.0013 0.0018
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0283 0.155
Loa Loa (eye worm) hypothetical protein 0.0094 0.1023 0.161
Onchocerca volvulus 0.003 0.0188 0.0281
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.016 0.1902 0.5927
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0028 0.0155 0.0153
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0013 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0081 0.0126
Brugia malayi hypothetical protein 0.0017 0.0013 0.0018
Mycobacterium leprae Possible regulatory protein 0.0028 0.0155 0.0372
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0328 0.4114 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0081 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0435 0.0434
Schistosoma mansoni dopamine-beta-monooxygenase 0.0525 0.6716 0.6715
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0119 0.0177
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0023 0.0033
Trichomonas vaginalis set domain proteins, putative 0.052 0.6642 1
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0012
Mycobacterium ulcerans endonuclease IV 0.0086 0.0923 0.4607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0012
Loa Loa (eye worm) DOMON domain-containing protein 0.0053 0.0489 0.0769
Echinococcus multilocularis lamin dm0 0.003 0.0188 0.0186
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0688 0.0686
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0119 0.136 0.1358
Toxoplasma gondii tetratricopeptide repeat-containing protein 0.0023 0.0091 0.0986
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0155 0.0787
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Brugia malayi bHLH-PAS transcription factor 0.0079 0.0831 0.1307
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0441 0.0439
Onchocerca volvulus 0.0017 0.0013 0.0018
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0081 0.008
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0651 0.065
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0283 0.082
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0021
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0155 0.0787
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0141
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0013 0.0012
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0013 0.0012
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0188 0.0294
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0013 0.0012
Schistosoma mansoni lipoxygenase 0.0203 0.2466 0.2465
Schistosoma mansoni opsin-like receptor 0.0017 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.4114 0.6133
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0023 0.0033
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0505
Echinococcus granulosus Ankyrin 0.0016 0.0004 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0081 0.0126
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0154 0.0152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0012
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0688 0.2097
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0081 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0322 0.1784
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0013 0.0012
Mycobacterium leprae conserved hypothetical protein 0.004 0.0322 0.1292
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 0.4114 0.6133
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0141 0.1646 0.2592
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0013 0.0018
Schistosoma mansoni adenoreceptor 0.0017 0.0013 0.0012
Schistosoma mansoni hypothetical protein 0.0372 0.4691 0.469
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0081 0.0126
Loa Loa (eye worm) DOMON domain-containing protein 0.0053 0.0489 0.0769
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0081 0.0126
Echinococcus granulosus serotonin receptor 0.0017 0.0013 0.0012
Brugia malayi G protein-coupled receptor 0.0017 0.0013 0.0018
Brugia malayi larval opioid receptor 0.0017 0.0013 0.0018

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 3.7 nM Binding affinity to human dopamine D4.4 receptor ChEMBL. 18164618
Ki (binding) = 3.7 nM Binding affinity to human dopamine D4.4 receptor ChEMBL. 18164618
Ki (binding) = 47 nM Displacement of [3H]prazosin from pig cortical membrane adrenergic alpha1 receptor ChEMBL. 18164618
Ki (binding) = 77 nM Binding affinity to human D3 receptor ChEMBL. 18164618
Ki (binding) = 77 nM Binding affinity to human D3 receptor ChEMBL. 18164618
Ki (binding) = 120 nM Binding affinity to human dopamine D2 long receptor ChEMBL. 18164618
Ki (binding) = 120 nM Binding affinity to pig cortical membrane 5HT1A receptor ChEMBL. 18164618
Ki (binding) = 120 nM Binding affinity to human dopamine D2 long receptor ChEMBL. 18164618
Ki (binding) = 3400 nM Binding affinity to pig cortical membrane dopamine D1 receptor ChEMBL. 18164618
Ki (binding) = 3400 nM Binding affinity to pig cortical membrane dopamine D1 receptor ChEMBL. 18164618
Ki (binding) = 5400 nM Displacement of [3H]ketanserin from pig cortical membrane 5HT2 receptor ChEMBL. 18164618
Ki (binding) = 5400 nM Displacement of [3H]ketanserin from pig cortical membrane 5HT2 receptor ChEMBL. 18164618

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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