Detailed information for compound 519519

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.419 | Formula: C19H24N4O2
  • H donors: 0 H acceptors: 4 LogP: 3.55 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCn1nnc(c1)CN1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C19H24N4O2/c1-2-3-4-5-6-9-12-22-13-15(20-21-22)14-23-18(24)16-10-7-8-11-17(16)19(23)25/h7-8,10-11,13H,2-6,9,12,14H2,1H3
  • InChiKey: AQYUSLGDWOEIIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Brugia malayi intermediate filament protein 0.0029 0.0124 0.0126
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0189 0.0189
Entamoeba histolytica rodhanase-like domain containing protein 0.0058 0.032 0.8176
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0058 0.032 0.0487
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0048 0.0637
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0013 0.0011 0.0011
Brugia malayi cathepsin F-like cysteine proteinase 0.0012 0.0003 0.0003
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.1085 0.1085
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0192 0.0196
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0026 0.0103 0.2744
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0221 0.1431 0.1459
Echinococcus multilocularis nAChR subunit 0.0013 0.0011 0.0011
Echinococcus multilocularis microtubule associated protein 2 0.1478 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Schistosoma mansoni cpg binding protein 0.0031 0.0136 0.0136
Brugia malayi Nuclear hormone receptor E75 0.0104 0.0635 0.0647
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0061 0.0341 0.0519
Brugia malayi nuclear hormone receptor 0.0221 0.1431 0.1459
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.1085 0.1107
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0001 0.0001
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0037 0.0174 0.0178
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0221 0.1431 0.1431
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0011 0.0011
Echinococcus granulosus dna polymerase kappa 0.0042 0.0211 0.0211
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0037 0.0174 0.0174
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0058 0.032 0.0487
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0472 0.314 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0165 0.0165
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0165 0.1048 0.3338
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0104 0.0635 0.0635
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0171 0.1092 0.1092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0221 0.1431 0.1459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0221 0.1431 0.2186
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.019 0.0194
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0386 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0174 0.0555
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0055 0.0297 0.0297
Mycobacterium tuberculosis Conserved protein 0.0039 0.019 0.117
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0048 0.0048
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.164 0.1673
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0174 0.0174
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0165 0.0165
Onchocerca volvulus Bile acid receptor homolog 0.0384 0.254 0.3883
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0221 0.1431 0.1431
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Brugia malayi nuclear receptor RXR 0.0117 0.072 0.0734
Onchocerca volvulus 0.0104 0.0635 0.0968
Schistosoma mansoni hypothetical protein 0.0539 0.3597 0.3597
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0103 0.0327
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0037 0.0174 0.0174
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0103 0.0836
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0026 0.0103 0.2744
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0221 0.1431 0.1459
Echinococcus granulosus ecdysone induced protein 78C 0.0221 0.1431 0.1431
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Mycobacterium tuberculosis Possible two component sensor kinase 0.0026 0.0103 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Schistosoma mansoni heat shock protein 0.0026 0.0103 0.0103
Schistosoma mansoni cpg binding protein 0.0031 0.0136 0.0136
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0237 0.6441
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0189 0.0189
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0087
Schistosoma mansoni pyruvate dehydrogenase 0.0472 0.314 0.314
Brugia malayi Carboxylesterase family protein 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0026 0.0103 0.063
Onchocerca volvulus 0.0061 0.0341 0.0519
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0192 0.0196
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0103 0.0327
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0062 0.0344 0.0351
Loa Loa (eye worm) hypothetical protein 0.0123 0.0761 0.0776
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.1262 0.1928
Mycobacterium tuberculosis Conserved protein 0.0039 0.019 0.117
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0189 0.0189
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0104 0.0635 0.0635
Brugia malayi hypothetical protein 0.0104 0.0635 0.0647
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Brugia malayi orphan nuclear receptor NR2E1 0.0104 0.0635 0.0647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0026 0.0103 0.063
Loa Loa (eye worm) doublecortin family protein 0.0061 0.0341 0.0348
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0092 0.7209
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0384 0.0384
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0268 0.0853
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0001 0.0039
Brugia malayi Pre-SET motif family protein 0.0123 0.0761 0.0776
Schistosoma mansoni z-protein (S1r protein) 0.0049 0.0255 0.0255
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0268 0.0853
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0026 0.0103 0.0327
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0013 0.0011 0.0011
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0103 0.1929
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1579 0.1579
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0085 0.0128
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0268 0.0268
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Schistosoma mansoni nuclear hormone receptor 0.0221 0.1431 0.1431
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0063 0.0515
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0013 0.0011 0.0011
Brugia malayi nuclear receptor RXR 0.0104 0.0635 0.0647
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.019 0.019
Schistosoma mansoni DNA polymerase eta 0.0015 0.0025 0.0025
Mycobacterium leprae Probable lipase LipE 0.0039 0.019 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0092 0.0562
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.0165 0.3992
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Schistosoma mansoni hypothetical protein 0.0155 0.0984 0.0984
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Brugia malayi Carboxylesterase family protein 0.0011 0.0001 0.0001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.042 0.2787 0.2787
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0221 0.1431 0.1431
Plasmodium vivax heat shock protein 86, putative 0.0026 0.0103 0.1308
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0268 0.0853
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0049 0.0255 0.026
Echinococcus granulosus protein tyrosine phosphatase n9 0.0037 0.0174 0.0174
Brugia malayi Nuclear hormone receptor-like 1 0.0221 0.1431 0.1459
Mycobacterium leprae Probable two component sensor kinase MprB 0.0026 0.0103 0.5383
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Brugia malayi hypothetical protein 0.0039 0.019 0.0194
Echinococcus multilocularis geminin 0.0539 0.3597 0.3597
Loa Loa (eye worm) fibroinase 0.0035 0.0165 0.0168
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0001 0.001
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Schistosoma mansoni heat shock protein 0.0026 0.0103 0.0103
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0364 0.2963
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Toxoplasma gondii heat shock protein 90, putative 0.0026 0.0103 0.0836
Onchocerca volvulus 0.0039 0.019 0.0289
Echinococcus granulosus neuroligin 0.0011 0.0001 0.0001
Loa Loa (eye worm) beta-lactamase 0.0039 0.019 0.0194
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0035 0.0165 0.025
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0386 0.0386
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0037 0.0174 0.0174
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0386 0.1228
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0192 0.0192
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0088 0.0521 0.0531
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0103 1
Echinococcus multilocularis lamin dm0 0.0029 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0268 0.0853
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0026 0.0103 0.0155
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.019 0.019
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0219 0.0219
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Schistosoma mansoni rab6-interacting 0.0061 0.0341 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0171 0.1092 0.1092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0761 0.0761
Brugia malayi tailless protein 0.0104 0.0635 0.0647
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0001 0.0001
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0037 0.0174 0.0264
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0103 0.1308
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0843 0.2685
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0165 0.0168
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0092 0.7209
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0219 0.0223
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.019 0.0289
Toxoplasma gondii cathepsin CPL 0.0035 0.0165 0.1344
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0322 0.2121 0.2121
Schistosoma mansoni pyruvate dehydrogenase 0.0445 0.2961 0.2961
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0025 0.0025
Loa Loa (eye worm) nuclear receptor NHR-67 0.0104 0.0635 0.0647
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0085 0.1669
Plasmodium vivax vivapain-2 0.0035 0.0165 0.2132
Loa Loa (eye worm) steroid hormone receptor 0.0221 0.1431 0.1459
Mycobacterium ulcerans two component sensor kinase MprB 0.0026 0.0103 0.2744
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0063 0.0201
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0037 0.0174 0.0174
Onchocerca volvulus 0.0058 0.032 0.0487
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Brugia malayi conserved hypotetical protein 0.0104 0.0635 0.0647
Entamoeba histolytica hypothetical protein 0.0039 0.019 0.4583
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0011 0.0011
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0056 0.0304 0.031
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0026 0.0103 0.0327
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0025 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0085 0.0085
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Brugia malayi PXA domain containing protein 0.0039 0.0189 0.0192
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0071 0.0227
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0055 0.0297 0.0297
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Echinococcus multilocularis lamin 0.0029 0.0124 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0211 0.0672
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.0165 0.3992
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0344 0.0344
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0165 0.388
Schistosoma mansoni loxhd1 0.0061 0.0341 0.0341
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0004 0.0004
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0103 0.0327
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus granulosus cathepsin l1 0.0035 0.0165 0.0165
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0026 0.0103 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0265 0.0265
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0189 0.0189
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0221 0.1431 0.1431
Onchocerca volvulus 0.0058 0.032 0.0487
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0255 0.0255
Plasmodium vivax hypothetical protein, conserved 0.0039 0.019 0.2469
Brugia malayi beta-lactamase family protein 0.0039 0.019 0.0194
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0103 0.0327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0058 0.032 0.0487
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0122
Trichomonas vaginalis cdc25b, putative 0.0058 0.032 0.0487
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Schistosoma mansoni polycystin 1-related 0.0061 0.0341 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0219 0.0332
Entamoeba histolytica rodhanase-like domain containing protein 0.0058 0.032 0.8176
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0386 0.0386
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.0635 0.0635
Schistosoma mansoni hypothetical protein 0.005 0.0261 0.0261
Echinococcus granulosus RUN 0.0061 0.0341 0.0341
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0092 0.0746
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0063 0.0063
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0189 0.0189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0048 0.0071
Onchocerca volvulus 0.0037 0.0174 0.0264
Entamoeba histolytica rodhanase-like domain containing protein 0.0058 0.032 0.8176
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.1085 0.1085
Brugia malayi ecdysteroid receptor 0.0384 0.254 0.259
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0063 0.0094
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0026 0.0103 0.063
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0268 0.0853
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0013 0.0011 0.0011
Leishmania major cysteine peptidase A (CPA) 0.0035 0.0165 0.0525
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.019 0.117
Mycobacterium leprae Probable two-component sensor kinase 0.0026 0.0103 0.5383
Echinococcus multilocularis hypothetical protein 0.0037 0.0174 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0221 0.1431 0.1431
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0283 0.0288
Trichomonas vaginalis cdc25b, putative 0.0058 0.032 0.0487
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0341 0.0341
Onchocerca volvulus 0.0035 0.0165 0.025
Onchocerca volvulus 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0386 0.0393
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0026 0.0103 0.2744
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.019 0.5098
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.019 0.019
Trichomonas vaginalis sensor histidine kinase, putative 0.0026 0.0103 0.0155
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0117 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0221 0.1431 0.1459
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0117 0.072 0.072
Brugia malayi Cathepsin L-like precursor 0.0024 0.0085 0.0087
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0189 0.0189
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Entamoeba histolytica hypothetical protein 0.0039 0.0189 0.454
Schistosoma mansoni steroid hormone receptor ad4bp 0.0221 0.1431 0.1431
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) ctsf protein 0.0035 0.0165 0.0168
Echinococcus multilocularis Polycystic kidney disease protein 0.0061 0.0341 0.0341
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0189 0.0189
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0026 0.0103 0.5383
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0374 0.0374
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0092 0.0291
Loa Loa (eye worm) nuclear hormone receptor 0.0104 0.0635 0.0647
Echinococcus granulosus lamin dm0 0.0029 0.0124 0.0124
Brugia malayi Cation transporter family protein 0.0013 0.0011 0.0011
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Schistosoma mansoni pyruvate dehydrogenase 0.0445 0.2961 0.2961
Loa Loa (eye worm) hypothetical protein 0.0054 0.0289 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Plasmodium vivax vivapain-3 0.0018 0.0048 0.0588
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0374 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0026 0.0103 0.2744
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0384 0.0384
Toxoplasma gondii DNA topoisomerase 2, putative 0.0026 0.0103 0.0836
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0103 0.0327
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0063
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.0165 0.3992
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0374 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0174 0.4135
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0026 0.0103 0.2744
Onchocerca volvulus 0.0037 0.0174 0.0264
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0063 0.0787
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.004 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0221 0.1431 0.1431
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0037 0.0174 0.0174
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0189 0.0189
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0048 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0048 0.0637
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0221 0.1431 0.1431
Leishmania major hypothetical protein, conserved 0.0026 0.0103 0.0327
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0384 0.0392
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0048 0.0153
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0123 0.0763 0.2431
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Brugia malayi hypothetical protein 0.0117 0.072 0.0734
Brugia malayi Probable DNA topoisomerase II 0.0026 0.0103 0.0105
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0189 0.0189
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0521 0.0531
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0237 0.8476
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0058 0.032 0.032
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0219 0.0696
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0189 0.0189
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Schistosoma mansoni DNA topoisomerase II 0.0026 0.0103 0.0103
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0211 0.5649
Brugia malayi Cation transporter family protein 0.0013 0.0011 0.0011
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0092 0.0746
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0026 0.0103 0.0103
Brugia malayi Protein-tyrosine phosphatase 1 0.0037 0.0174 0.0178
Schistosoma mansoni nuclear receptor 0.0104 0.0635 0.0635
Plasmodium falciparum DNA gyrase subunit B 0.0026 0.0103 0.1863
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Brugia malayi nuclear hormone receptor family member nhr-6 0.0104 0.0635 0.0647
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0058 0.032 0.0487
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0221 0.1431 0.1431
Loa Loa (eye worm) cysteine protease 0.0035 0.0165 0.0168
Schistosoma mansoni zinc finger protein 0.0104 0.0635 0.0635
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0063 0.0094
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0026 0.0103 0.063
Loa Loa (eye worm) TOPoisomerase family member 0.0026 0.0103 0.0105
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Schistosoma mansoni nuclear receptor 0.0104 0.0635 0.0635
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0103 0.0155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0037 0.0174 0.0555
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0025 0.0025
Onchocerca volvulus 0.0123 0.0761 0.1162
Schistosoma mansoni nuclear receptor nhr-48 0.0104 0.0635 0.0635
Mycobacterium ulcerans two component regulator - sensor kinase 0.0026 0.0103 0.2744
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.019 0.0607
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Trichomonas vaginalis set domain proteins, putative 0.097 0.6539 1
Trypanosoma cruzi cruzipain precursor, putative 0.0012 0.0003 0.0011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0026 0.0103 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0268 0.0408
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0013 0.0011 0.0011
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0344 0.0344
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0103 0.0836
Trypanosoma brucei protein kinase, putative 0.005 0.0268 0.0853
Brugia malayi beta-lactamase family protein 0.0039 0.019 0.0194
Entamoeba histolytica hypothetical protein 0.0039 0.0189 0.454
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0117 0.072 0.0734
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0168
Brugia malayi hypothetical protein 0.0039 0.0189 0.0192
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.072 0.0734
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0026 0.0103 0.063
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Echinococcus granulosus nAChR subunit 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0068 0.0384 0.0392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0013 0.0011 0.0011
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0026 0.0103 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0211 0.5649
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0103 0.0327
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0001 0.0009
Plasmodium falciparum endoplasmin, putative 0.0026 0.0103 0.1863
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0026 0.0103 0.063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0048 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0843 0.2685
Onchocerca volvulus 0.0013 0.0011 0.0014
Plasmodium vivax vivapain-1 0.0018 0.0048 0.0588
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.002 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0189 0.0189
Onchocerca volvulus 0.0221 0.1431 0.2186
Entamoeba histolytica hypothetical protein 0.0039 0.019 0.4583
Brugia malayi nuclear receptor NHR-88 0.0221 0.1431 0.1459
Echinococcus multilocularis RUN 0.0061 0.0341 0.0341
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0268 1
Onchocerca volvulus 0.0037 0.0174 0.0264
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.019 0.0289
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0103 0.0327
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0219 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0646 0.2058
Echinococcus granulosus cysteine protease 0.0018 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0037 0.0174 0.0174
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0048 0.0637
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0219 0.7593
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0071 0.0437
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Echinococcus granulosus dnaJ subfamily B 0.042 0.2787 0.2787
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0221 0.1431 0.1431
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0104 0.0635 0.0635
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0025 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Onchocerca volvulus 0.0037 0.0174 0.0264
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0048 0.0153
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.019 0.0194
Brugia malayi Doublecortin family protein 0.0061 0.0341 0.0348
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0521 0.0521
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0013 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0103 0.0327
Leishmania major cathepsin L-like protease 0.0135 0.0843 0.2685
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.0635 0.0968
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0221 0.1431 0.1459
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0189 0.0189
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0058 0.032 0.0487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0085 0.0128
Loa Loa (eye worm) carboxylesterase 0.0011 0.0001 0.0001
Brugia malayi nuclear receptor NHR-88 0.0104 0.0635 0.0647
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0011 0.0011
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0103 0.0155
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0048 0.0048
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0221 0.1431 0.1459
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0068 0.0384 0.0392
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0124 0.0126
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0189 0.0189
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus nuclear receptor nhr 48 0.0104 0.0635 0.0635
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0189 0.0192
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.019 0.0607
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0001 0.0009
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0025
Brugia malayi Carboxylesterase family protein 0.0068 0.0384 0.0392
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Echinococcus granulosus intermediate filament protein 0.0029 0.0124 0.0124
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.019 0.0289
Schistosoma mansoni rab6-interacting 0.0061 0.0341 0.0341
Schistosoma mansoni hypothetical protein 0.0039 0.019 0.019
Onchocerca volvulus 0.0037 0.0174 0.0264
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0268 0.0408
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0037 0.0174 0.0178
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0243 0.1579 0.1611
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0048 0.0637
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0026 0.0103 1
Leishmania major cathepsin L-like protease 0.0135 0.0843 0.2685
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0174 0.0174
Echinococcus multilocularis thyroid hormone receptor alpha 0.0221 0.1431 0.1431
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0268 0.2184
Trypanosoma cruzi Heat shock protein 83, putative 0.0026 0.0103 0.0327
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0092 0.2449
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0017
Schistosoma mansoni lamin 0.0029 0.0124 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0221 0.1431 0.1459
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0374 1
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0165 0.0165
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.0761 0.6203
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0103 0.2151
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1449 0.9804 0.9804
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0219 0.0332
Trypanosoma brucei Heat shock protein 83, putative 0.0026 0.0103 0.0327
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0221 0.1431 0.1431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Onchocerca volvulus 0.0088 0.0521 0.0794
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.0165 0.0165
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.0761 0.0761
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0103 0.0327
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0341 0.0341
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0025 0.0025
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0026 0.0103 0.063
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Entamoeba histolytica hypothetical protein 0.0039 0.019 0.4583
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0384 0.0384
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Giardia lamblia Pms1-like protein 0.0026 0.0103 0.1929
Toxoplasma gondii heat shock protein HSP90 0.0026 0.0103 0.0836
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0026 0.0103 0.063
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0063 0.0387
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0013 0.0011 0.0011
Echinococcus granulosus cathepsin L 0.0018 0.0048 0.0048
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0026 0.0103 0.0155
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0219 0.0219
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0031 0.0031
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0048 0.0637
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0048 0.0153
Onchocerca volvulus 0.0035 0.0165 0.025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0016 0.0016
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0165 0.1048 0.3338
Leishmania major DNA polymerase kappa, putative 0.0022 0.0071 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0221 0.1431 0.1431
Trypanosoma brucei DNA topoisomerase ii 0.0026 0.0103 0.0327
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0374 0.2295
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0026 0.0103 0.063
Onchocerca volvulus 0.0029 0.0124 0.0187
Toxoplasma gondii ABC1 family protein 0.0039 0.019 0.1552
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0221 0.1431 0.1459
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0048 0.0049
Mycobacterium tuberculosis Probable two component sensor kinase 0.0026 0.0103 0.063
Loa Loa (eye worm) hypothetical protein 0.0061 0.0341 0.0348
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0174 0.0178
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0055 0.0297 0.0303
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0221 0.1431 0.1459
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus multilocularis neuroligin 0.0011 0.0001 0.0001
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0126
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.019 0.117
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0189 0.0189
Brugia malayi nuclear receptor NHR-67 0.0104 0.0635 0.0647
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0852 0.5736 0.5851
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0189 0.0192
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0013 0.0011 0.0011
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0026 0.0103 1
Onchocerca volvulus 0.0037 0.0174 0.0264
Trypanosoma brucei protein tyrosine phosphatase 1 0.0037 0.0174 0.0555
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0174 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0227
Onchocerca volvulus 0.0037 0.0174 0.0264
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0189 0.0192
Brugia malayi PXA domain containing protein 0.0039 0.0189 0.0192
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0103 0.0155
Brugia malayi hypothetical protein 0.0061 0.0341 0.0348
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0255 0.0255
Brugia malayi Rhodanese-like domain containing protein 0.0058 0.032 0.0326
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Schistosoma mansoni coup transcription factor 0.0221 0.1431 0.1431
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0192 0.0192
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0003 0.0003
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0054 0.0289 0.0295
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0165 0.1048 0.8542
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0085 0.0087
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0211 0.0211
Echinococcus granulosus histone acetyltransferase KAT2B 0.0166 0.1052 0.1052
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0124 0.0126
Schistosoma mansoni microtubule-associated protein tau 0.1478 1 1
Brugia malayi hypothetical protein 0.0104 0.0635 0.0647
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Brugia malayi excitatory GABA receptor EXP-1A 0.0013 0.0011 0.0011
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Plasmodium falciparum LCCL domain-containing protein 0.0061 0.0341 1
Schistosoma mansoni lipoxygenase 0.0171 0.1092 0.1092
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Brugia malayi regulator of G-protein signaling egl-10 0.0049 0.0255 0.026
Onchocerca volvulus 0.0039 0.019 0.0289
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0092 0.0291
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0092 0.1163
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0205 0.1325 0.1325
Onchocerca volvulus 0.0037 0.0174 0.0264
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0189 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0105
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0221 0.1431 0.1459
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0165 0.025
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Onchocerca volvulus 0.0037 0.0174 0.0264
Schistosoma mansoni survival motor neuron protein 0.005 0.0261 0.0261
Plasmodium falciparum heat shock protein 90 0.0026 0.0103 0.1863
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0026 0.0103 0.5383
Entamoeba histolytica cysteine protease, putative 0.0035 0.0165 0.388
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0726 0.0726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Echinococcus multilocularis expressed protein 0.0757 0.5086 0.5086
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0103 0.0155
Schistosoma mansoni gliotactin 0.0011 0.0001 0.0001
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0255 0.0255
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0117 0.072 0.072
Trypanosoma brucei developmentally regulated phosphoprotein 0.0472 0.314 1
Echinococcus multilocularis cysteine protease 0.0035 0.0165 0.0165
Schistosoma mansoni cathepsin s 0.0012 0.0003 0.0003
Schistosoma mansoni pcd6 interacting protein-related 0.0037 0.0174 0.0174
Onchocerca volvulus 0.005 0.0261 0.0397
Brugia malayi Endoplasmin precursor 0.0026 0.0103 0.0105
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.002 0.002
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0472 0.314 0.314
Echinococcus granulosus expressed protein 0.0757 0.5086 0.5086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0761 0.0761
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0001 0.0009
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0384 0.0384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0268 0.0268
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1579 0.1579
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0189 0.0189
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0092 0.2449
Plasmodium vivax SET domain protein, putative 0.0123 0.0761 1
Onchocerca volvulus 0.0013 0.0011 0.0014
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0037 0.0174 0.0174
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0025 0.0025
Brugia malayi MAP kinase sur-1 0.005 0.0268 0.0273
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0025 0.0079
Onchocerca volvulus 0.0029 0.0125 0.0188
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.0165 0.0168
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0013 0.0011 0.0011
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0001 0.0001
Echinococcus granulosus acetylcholinesterase 0.0068 0.0384 0.0384
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0219 0.0696
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0011 0.0011
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.019 0.019
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0174 0.0174
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0037 0.0174 0.0264
Brugia malayi N-terminal motif family protein 0.0196 0.1262 0.1287
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0013 0.0011 0.0011
Toxoplasma gondii exonuclease III APE 0.002 0.0063 0.0514
Plasmodium vivax multidomain scavenger receptor, putative 0.0061 0.0341 0.4456
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Brugia malayi hypothetical protein 0.0037 0.0174 0.0178
Plasmodium falciparum DNA topoisomerase 2 0.0026 0.0103 0.1863
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0268 0.0273
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0103 0.0155
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0104 0.0635 0.0647
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.004 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0013 0.0011 0.0011
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.0635 0.0635
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0219 0.0696
Onchocerca volvulus 4.1 G protein, putative homolog 0.0037 0.0174 0.0264
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0221 0.1431 0.1459
Loa Loa (eye worm) hypothetical protein 0.0056 0.0304 0.031
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0092 0.1487
Loa Loa (eye worm) carboxylesterase 0.0068 0.0384 0.0392
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0472 0.314 0.314
Mycobacterium tuberculosis Conserved protein 0.0026 0.0103 0.063
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0265 0.2161
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.019 0.019
Brugia malayi CXXC zinc finger family protein 0.0029 0.0125 0.0127
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0048 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Trichomonas vaginalis esterase, putative 0.0039 0.019 0.0289
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0037 0.0174 0.0174
Leishmania major DNA polymerase eta, putative 0.0015 0.0025 0.0079
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0341 0.0341
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0165 0.388
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0386 0.0386
Trichomonas vaginalis cdc25c, putative 0.0058 0.032 0.0487
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Brugia malayi Rhodanese-like domain containing protein 0.0058 0.032 0.0326
Schistosoma mansoni RAR-like nuclear receptor 0.0221 0.1431 0.1431
Brugia malayi photoreceptor-specific nuclear receptor 0.0221 0.1431 0.1459
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0192
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Loa Loa (eye worm) protein tyrosine phosphatase 0.0037 0.0174 0.0178
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.019 0.019
Schistosoma mansoni acetylcholinesterase 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0087
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0063 0.1686
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0174 0.0174
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.019 0.0607
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0189 0.0286
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0174 0.0174
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0013 0.0011 0.0011
Echinococcus granulosus Polycystic kidney disease protein 0.0061 0.0341 0.0341
Leishmania major developmentally regulated phosphoprotein-like protein 0.0472 0.314 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.0761 0.0761
Mycobacterium ulcerans hypothetical protein 0.0039 0.019 0.5098
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Loa Loa (eye worm) heat shock protein 90 0.0026 0.0103 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0048 0.0153
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0103 0.0327
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0026 0.0103 0.063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.019 0.117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0761 0.0761
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0165 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0026 0.0103 0.063
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0221 0.1431 0.1431
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0221 0.1431 0.1431
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus multilocularis 0.0037 0.0174 0.0174
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0192 0.0196
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0004 0.0004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) carboxylesterase 0.0011 0.0001 0.0001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0174 0.0555
Brugia malayi Carboxylesterase family protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0058 0.032 0.0326
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0191 0.1227 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.0635 0.0635
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0221 0.1431 0.1431
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0039 0.019 0.0194
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0104 0.0635 0.0635
Schistosoma mansoni hypothetical protein 0.042 0.2787 0.2787
Loa Loa (eye worm) acetyltransferase 0.017 0.1085 0.1107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Brugia malayi Steroid receptor seven-up type 2 0.0221 0.1431 0.1459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0048 0.0071
Mycobacterium ulcerans putative regultory protein 0.0026 0.0103 0.2744
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0189 0.0286
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0024 0.0085 0.0087
Onchocerca volvulus 0.0035 0.0165 0.025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0221 0.1431 0.1459
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0144
Echinococcus granulosus heat shock protein 90 0.0026 0.0103 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0165 0.025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0268 0.0268
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0221 0.1431 0.1431
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0386 0.1228
Entamoeba histolytica hypothetical protein 0.0039 0.019 0.4583
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0268 0.0853
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0219 0.0219
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0011 0.0011
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0013 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0141 0.045
Brugia malayi steroid hormone receptor 0.0221 0.1431 0.1459
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0062 0.0344 0.0351
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0174 0.0555
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0189 0.0189
Onchocerca volvulus 0.0037 0.0174 0.0264
Brugia malayi Carboxylesterase family protein 0.0068 0.0384 0.0392
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0221 0.1431 0.1431
Loa Loa (eye worm) GABA receptor subunit 0.0056 0.0304 0.031
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus granulosus cathepsin l1 0.0024 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0123 0.0761 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Onchocerca volvulus 0.0029 0.0124 0.0187
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0013 0.0011 0.0011
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Brugia malayi kinase, mitochondrial precursor 0.0472 0.314 0.3203
Leishmania major cathepsin L-like protease 0.0135 0.0843 0.2685
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0026 0.0103 0.0103
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0374 0.3046
Brugia malayi beta-lactamase 0.0039 0.019 0.0194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.0201
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0386 0.1228
Trichomonas vaginalis pten, drome, putative 0.0037 0.0174 0.0264
Echinococcus multilocularis musashi 0.0029 0.0124 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0192 0.0192
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0221 0.1431 0.1431
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0211 0.0321
Onchocerca volvulus 0.0104 0.0635 0.0968
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0165 0.0525
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0117 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0103 0.0155
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.019 0.117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0221 0.1431 0.1459
Brugia malayi hypothetical protein 0.0243 0.1579 0.1611
Schistosoma mansoni endoplasmin 0.0026 0.0103 0.0103
Brugia malayi follicle stimulating hormone receptor 0.0252 0.164 0.1673
Trypanosoma brucei unspecified product 0.0035 0.0165 0.0525
Onchocerca volvulus 0.0013 0.0011 0.0014
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0386 0.1228
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0219 0.5368
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.019 0.5098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.019 0.117
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus granulosus cpg binding protein 0.0031 0.0136 0.0136
Onchocerca volvulus 0.097 0.6539 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.0635 0.0635
Schistosoma mansoni hypothetical protein 0.0061 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) LGC-31 protein 0.0013 0.0011 0.0011
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0174 0.0174
Echinococcus granulosus dna polymerase eta 0.0015 0.0025 0.0025
Schistosoma mansoni lamin 0.0029 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0085 0.0128
Onchocerca volvulus Putative nachr subunit 0.0013 0.0011 0.0014
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0189 0.0192
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0191 0.0191
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0055 0.0297 0.0303
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.072 0.0734
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0001 0.0001
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0165 0.0165
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0026 0.0103 0.0155
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0268 0.0268
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0211 0.0321
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0048 0.0048
Schistosoma mansoni lipoxygenase 0.0061 0.0341 0.0341
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Mycobacterium ulcerans DNA gyrase subunit B 0.0026 0.0103 0.2744
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Brugia malayi Cytochrome P450 family protein 0.0053 0.0283 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0221 0.1431 0.1459
Echinococcus multilocularis ecdysone induced protein 78C 0.0221 0.1431 0.1431
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0103 0.0155
Giardia lamblia DINP protein human, muc B family 0.0022 0.0071 0.0396
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0026 0.0103 0.2744
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0521 0.0521
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0016 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0843 0.2685
Trypanosoma cruzi cruzipain precursor, putative 0.0135 0.0843 0.2685
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0374 0.119
Echinococcus multilocularis cpg binding protein 0.0031 0.0136 0.0136
Schistosoma mansoni endoplasmin 0.0026 0.0103 0.0103
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0011 0.0011
Schistosoma mansoni nAChR subunit 0.0013 0.0011 0.0011
Loa Loa (eye worm) endoplasmin 0.0026 0.0103 0.0105
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0219 0.0219
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0103 0.0327
Brugia malayi Carboxylesterase family protein 0.0011 0.0001 0.0001
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0237 0.587
Schistosoma mansoni cpg binding protein 0.0029 0.0125 0.0125
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0268 0.0408
Plasmodium vivax unspecified product 0.0018 0.0048 0.0588
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0058 0.032 0.0487
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0104 0.0635 0.0647
Onchocerca volvulus 0.0013 0.0011 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0165 0.025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1449 0.9804 1
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0165 0.025
Trichomonas vaginalis endoplasmin, putative 0.0026 0.0103 0.0155
Leishmania major DNA topoisomerase ii 0.0026 0.0103 0.0327
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0344 0.0344
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0063 0.1055
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.0201
Loa Loa (eye worm) hypothetical protein 0.0061 0.0341 0.0348
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Brugia malayi heat shock protein 90 0.0026 0.0103 0.0105
Brugia malayi nuclear hormone receptor family member odr-7 0.0104 0.0635 0.0647
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0219 0.0696
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0037 0.0174 0.4135
Schistosoma mansoni regulator of G protein signaling 0.0049 0.0255 0.0255
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.019 0.117
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0386 0.0393
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0189 0.0192
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0189 0.0189
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0063 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0048 0.0153
Brugia malayi ecdysone receptor 0.0104 0.0635 0.0647
Plasmodium vivax DNA gyrase subunit B, putative 0.0026 0.0103 0.1308
Entamoeba histolytica hypothetical protein 0.0025 0.0092 0.1845
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0037 0.0174 0.0174
Echinococcus granulosus FTZ F1 alpha 0.0221 0.1431 0.1431
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Onchocerca volvulus Cathepsin F homolog 0.0035 0.0165 0.025
Echinococcus granulosus heat shock protein 0.0026 0.0103 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.004 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0037 0.0174 0.0264
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0016 0.0016
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0221 0.1431 0.1431
Plasmodium vivax endoplasmin, putative 0.0026 0.0103 0.1308
Brugia malayi Nuclear hormone receptor E75 0.0104 0.0635 0.0647
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Plasmodium vivax vivapain-2 0.0035 0.0165 0.2132
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0211 0.0672
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Brugia malayi hypothetical protein 0.0117 0.072 0.0734
Echinococcus multilocularis cysteine protease 0.0035 0.0165 0.0165
Entamoeba histolytica DNA topoisomerase II, putative 0.0026 0.0103 0.2151
Schistosoma mansoni hypothetical protein 0.0539 0.3597 0.3597
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0026 0.0103 0.2744
Loa Loa (eye worm) hypothetical protein 0.0117 0.072 0.0734
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0221 0.1431 0.1459
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0125 0.0127
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0011 0.0011
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0103 0.2151
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Echinococcus multilocularis heat shock protein 90 0.0026 0.0103 0.0103
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.1629 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0192 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0221 0.1431 0.1459
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.0223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0221 0.1431 0.1459
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0174 0.0174
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0092 0.4804
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0012 0.0003 0.0003
Brugia malayi hypothetical protein 0.0061 0.0341 0.0348
Schistosoma mansoni nuclear hormone receptor 0.0104 0.0635 0.0635
Schistosoma mansoni retinoic acid receptor RXR 0.0322 0.2121 0.2121
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0048 0.0049
Trichomonas vaginalis DNA topoisomerase II, putative 0.0026 0.0103 0.0155
Loa Loa (eye worm) hypothetical protein 0.0058 0.032 0.0326
Mycobacterium leprae conserved hypothetical protein 0.0039 0.019 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0011 0.0011
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Onchocerca volvulus 0.0013 0.0011 0.0014
Brugia malayi cathepsin L-like precursor 0.0024 0.0085 0.0087
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0037 0.0174 0.0178
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0268 0.0853
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.0635 0.0968
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0268 0.0408
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1449 0.9804 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0174 0.4135
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0219 0.0219
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0103 0.0155
Leishmania major tyrosine specific protein phosphatase, putative 0.0037 0.0174 0.0555
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Leishmania major hypothetical protein, conserved 0.0039 0.019 0.0607
Onchocerca volvulus Protein ultraspiracle homolog 0.0221 0.1431 0.2186
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.026
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Onchocerca volvulus 0.0035 0.0165 0.025
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0165 0.1048 0.3338
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0374 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0221 0.1431 0.1459
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0265 0.0403
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0219 0.0219
Leishmania major cathepsin L-like protease 0.0035 0.0165 0.0525
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0124 0.0126
Echinococcus granulosus geminin 0.0539 0.3597 0.3597
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1449 0.9804 0.9804
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1449 0.9804 0.9804
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0013 0.0011 0.0011
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0026 0.0103 1
Trypanosoma brucei heat shock protein, putative 0.0026 0.0103 0.0327
Trypanosoma cruzi cysteine peptidase, putative 0.0012 0.0003 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0221 0.1431 0.1431
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0011 0.0011
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0189 0.0189
Echinococcus granulosus thyroid hormone receptor alpha 0.0104 0.0635 0.0635
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0103 0.0327
Leishmania major mitochondrial DNA topoisomerase II 0.0026 0.0103 0.0327
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0265 0.2161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Mycobacterium ulcerans beta-lactamase 0.0039 0.019 0.5098
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0341 0.0341
Loa Loa (eye worm) DR-78 0.0104 0.0635 0.0647
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0384 0.254 0.259
Entamoeba histolytica cysteine protease, putative 0.0018 0.0048 0.0637
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0063 0.0201
Echinococcus multilocularis nuclear receptor nhr 48 0.0104 0.0635 0.0635
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0192 0.0192
Brugia malayi nuclear hormone receptor 0.0104 0.0635 0.0647
Brugia malayi Cathepsin L-like precursor 0.0035 0.0165 0.0168
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0011 0.0011
Schistosoma mansoni intermediate filament proteins 0.0029 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0174 0.0174
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0265 0.0403
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Brugia malayi hypothetical protein 0.0039 0.0189 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0165 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0211 0.0672
Onchocerca volvulus 0.0037 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0141 0.045
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.019 0.0289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0165 0.025
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0219 0.0219
Echinococcus multilocularis cathepsin L 0.0018 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0196 0.1262 0.1287
Brugia malayi Cation transporter family protein 0.0062 0.0344 0.0351
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0013 0.0011 0.0011
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Echinococcus multilocularis heat shock protein 0.0026 0.0103 0.0103
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0221 0.1431 0.1431
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.019 0.117
Giardia lamblia Protein tyrosine phosphatase 0.0037 0.0174 0.5421
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Plasmodium vivax DNA topoisomerase II, putative 0.0026 0.0103 0.1308
Onchocerca volvulus 0.0039 0.019 0.0289
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0174 0.0174
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0058 0.032 0.032
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0174 0.0174
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0174 0.0174
Echinococcus granulosus acetylcholinesterase 0.0068 0.0384 0.0384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Onchocerca volvulus 0.0037 0.0174 0.0264
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0123 0.0761 0.0761
Echinococcus multilocularis dna polymerase eta 0.0015 0.0025 0.0025
Brugia malayi Pre-SET motif family protein 0.0852 0.5736 0.5851
Leishmania major heat shock protein 83-1 0.0026 0.0103 0.0327
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0013 0.0011 0.0011
Brugia malayi polk-prov protein 0.0032 0.0141 0.0144
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0265 0.3455
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0058 0.032 0.032
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0026 0.0103 1
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0026 0.0103 0.1863
Mycobacterium ulcerans lipase LipD 0.0039 0.019 0.5098
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.019 0.0289
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0472 0.314 0.3203
Echinococcus granulosus lamin 0.0029 0.0124 0.0124
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0026 0.0103 0.2744
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0261 0.0266
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0174 0.0178
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0037 0.0174 0.0178
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0165 0.0168
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0026 0.0103 0.0105
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0178
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0472 0.314 0.314
Onchocerca volvulus 0.0058 0.032 0.0487
Onchocerca volvulus 0.0013 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0063 0.0064
Mycobacterium tuberculosis Conserved protein 0.0039 0.019 0.117
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0221 0.1431 0.1459
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0221 0.1431 0.1459
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0165 0.0165
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0004 0.0004
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0037 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0647
Brugia malayi Cathepsin L-like precursor 0.0012 0.0003 0.0003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0174 0.0178
Schistosoma mansoni thyroid hormone receptor 0.0221 0.1431 0.1431
Entamoeba histolytica hypothetical protein 0.0039 0.0189 0.454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0221 0.1431 0.1459
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0062 0.0344 0.0344
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0174 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0843 0.2685
Schistosoma mansoni nuclear hormone receptor 0.0104 0.0635 0.0635

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Growth inhibition of Staphylococcus aureus ATCC 25923 at 0.1 mg/ml after 24 hrs ChEMBL. 18086525
Inhibition (functional) = 24 % Growth inhibition of Staphylococcus aureus RN4220 expressing MsrA at 0.1 mg/ml after 24 hrs in presence of 16 mg/L erythromycin ChEMBL. 18086525
Inhibition (functional) = 25 % Growth inhibition of Staphylococcus aureus 1199B expressing NorA at 0.1 mg/ml after 24 hrs in presence of 4 mg/L ciprofloxacin ChEMBL. 18086525
Inhibition (functional) = 27.4 % Growth inhibition of Staphylococcus aureus 1199B expressing NorA at 0.1 mg/ml after 24 hrs ChEMBL. 18086525
Inhibition (functional) = 40 % Growth inhibition of Staphylococcus aureus RN4220 expressing MsrA at 0.1 mg/ml after 24 hrs ChEMBL. 18086525

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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