Detailed information for compound 574728

Basic information

Technical information
  • TDR Targets ID: 574728
  • Name: stylatulide
  • MW: 527.004 | Formula: C26H35ClO9
  • H donors: 0 H acceptors: 4 LogP: 2.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)OC1C2C(OC(=O)C2C)C(Cl)C(=C)CCC(C2(C1C1(C)OC1CC2OC(=O)C)C)OC(=O)C
  • InChi: 1S/C26H35ClO9/c1-11-8-9-16(32-13(3)28)25(6)17(33-14(4)29)10-18-26(7,36-18)23(25)22(34-15(5)30)19-12(2)24(31)35-21(19)20(11)27/h12,16-23H,1,8-10H2,2-7H3
  • InChiKey: ALCDJXWWURFGPE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NCI60_002359
  • NSC287457
  • 11,12-Epoxybenzo[4,5]cyclodeca[1,2-b]furan-2(1H)-one, 8,9,13-tris(acetyloxy)-4-chlorotetradecahydro-1,8a,12-trimethyl-5-methylene-
  • AIDS-031201
  • AIDS031201

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0046 0.1188
Echinococcus granulosus hypothetical protein 0.0179 0.0169 0.0168
Schistosoma mansoni cpg binding protein 0.0032 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Trichomonas vaginalis sphingosine kinase, putative 0.0386 0.0378 1
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0014 0.0162
Loa Loa (eye worm) hypothetical protein 0.0462 0.0454 0.0453
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0106 0.0095 0.0093
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0039 0.0027 0.0023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0154 0.177
Loa Loa (eye worm) hypothetical protein 0.0106 0.0095 0.0093
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0179 0.0169 0.0168
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0078 0.0078
Echinococcus multilocularis serotonin receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0179 0.0169 0.0168
Brugia malayi beta-lactamase family protein 0.0106 0.0095 0.1087
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Trichomonas vaginalis diacylglycerol kinase, putative 0.0386 0.0378 1
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0004 0.0074
Schistosoma mansoni intermediate filament proteins 0.008 0.0069 0.0069
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0039 0.0027 0.0023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0025 0.0616
Onchocerca volvulus 0.0179 0.0169 0.4438
Schistosoma mansoni alpha-glucosidase 0.0142 0.0131 0.0131
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0002 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0146 0.0135 0.0135
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0022 0.0021
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0014 0.0262
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0025 0.0631
Schistosoma mansoni hypothetical protein 0.0386 0.0378 0.0378
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0179 0.0169 0.0168
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0025 0.0607
Loa Loa (eye worm) hypothetical protein 0.0235 0.0225 0.0223
Echinococcus granulosus lamin dm0 0.008 0.0069 0.0069
Echinococcus granulosus ceramide kinase 0.0386 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0069 0.0057 0.0056
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0045 0.113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0074
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0002 0.0002
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0386 0.0378 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Schistosoma mansoni neuropeptide f receptor 76f 0.0179 0.0169 0.0168
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0018 0.0016
Echinococcus multilocularis neuropeptide receptor A26 0.112 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0025
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0039 0.0027 0.0023
Mycobacterium tuberculosis Conserved protein 0.0106 0.0095 0.009
Onchocerca volvulus 0.0106 0.0095 0.2476
Echinococcus multilocularis dro:myosuppressin receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0386 0.0378 0.0376
Echinococcus multilocularis Diacylglycerol kinase theta 0.0386 0.0378 0.0378
Echinococcus multilocularis neuropeptides capa receptor 0.0179 0.0169 0.0168
Onchocerca volvulus 0.0179 0.0169 0.4438
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0027 0.0682
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0197 0.0197
Echinococcus multilocularis g-protein coupled receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) RNA binding protein 0.0207 0.0197 0.0195
Loa Loa (eye worm) diacylglycerol kinase 2 0.0386 0.0378 0.0376
Schistosoma mansoni cpg binding protein 0.003 0.0018 0.0018
Schistosoma mansoni amine GPCR 0.0179 0.0169 0.0168
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0179 0.0169 0.1934
Schistosoma mansoni myosin xvIII 0.0179 0.0169 0.0168
Toxoplasma gondii cytochrome p450 superfamily protein 0.0039 0.0027 0.0649
Trypanosoma brucei diacylglycerol kinase, putative 0.0386 0.0378 1
Brugia malayi RE15519p 0.0179 0.0169 0.1934
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0004 0.0074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0462 0.0454 0.0453
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0002 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0025 0.0616
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0027 0.0313
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0092 0.2378
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0014
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0179 0.0169 0.0168
Echinococcus granulosus neuropeptide Y receptor 0.0179 0.0169 0.0168
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0039 0.0027 0.0023
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0039 0.0027 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Brugia malayi GnHR receptor homolog 0.0179 0.0169 0.1934
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0365 0.0356 0.4086
Schistosoma mansoni hypothetical protein 0.0146 0.0135 0.0135
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0022 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0197 0.0197
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0095 0.2476
Schistosoma mansoni hypothetical protein 0.0146 0.0135 0.0135
Toxoplasma gondii exonuclease III APE 0.0039 0.0027 0.0658
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0058 0.0046 0.0042
Mycobacterium leprae putative cytochrome p450 0.0039 0.0027 0.0632
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0039 0.0027 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Onchocerca volvulus 0.003 0.0018 0.0436
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0022 0.0532
Brugia malayi Cytochrome P450 family protein 0.0058 0.0046 0.0531
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.0095 0.1087
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0095 0.2476
Loa Loa (eye worm) CYP4Cod1 0.0058 0.0046 0.0045
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0036 0.0902
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0025 0.0631
Echinococcus multilocularis musashi 0.008 0.0069 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0095 0.2476
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0002 0.0002
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0004 0.0048
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0069 0.0067
Schistosoma mansoni diacylglycerol kinase theta 0.0386 0.0378 0.0378
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0386 0.0378 1
Echinococcus granulosus tm gpcr rhodopsin 0.0179 0.0169 0.0168
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0039 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Onchocerca volvulus 0.0179 0.0169 0.4438
Trypanosoma cruzi diacylglycerol kinase, putative 0.0386 0.0378 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0039 0.0027 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0095 0.2476
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Brugia malayi G protein-coupled receptor 0.0179 0.0169 0.1934
Brugia malayi MH2 domain containing protein 0.0117 0.0106 0.1222
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0014 0.0014
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0039 0.0027 0.0673
Brugia malayi neuropeptide F receptor 0.0179 0.0169 0.1934
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0015 0.0362
Schistosoma mansoni sphingoid long chain base kinase 0.9914 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0039 0.0027 0.0023
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0025 0.0616
Onchocerca volvulus 0.0179 0.0169 0.4438
Echinococcus multilocularis ceramide kinase 0.0386 0.0378 0.0378
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0002 0.0002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0179 0.0169 0.0168
Echinococcus granulosus g protein coupled receptor 0.0179 0.0169 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0179 0.0169 0.0168
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0179 0.0169 0.0168
Schistosoma mansoni diacylglycerol kinase theta 0.0386 0.0378 0.0378
Echinococcus granulosus neuropeptide receptor 0.0179 0.0169 0.0168
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0036 0.0031
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0386 0.0378 0.0376
Echinococcus multilocularis G protein coupled receptor 139 0.0179 0.0169 0.0168
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0004 0.0074
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0386 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Trypanosoma brucei Sphingosine kinase 0.0386 0.0378 1
Trichomonas vaginalis diacylglycerol kinase, putative 0.0386 0.0378 1
Loa Loa (eye worm) inositol-1 0.0037 0.0025 0.0024
Onchocerca volvulus 0.0179 0.0169 0.4438
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0179 0.0169 0.0168
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0025 0.0616
Echinococcus multilocularis g protein coupled receptor 0.0179 0.0169 0.0168
Schistosoma mansoni hypothetical protein 0.0048 0.0036 0.0036
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0179 0.0169 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Plasmodium vivax glutathione reductase, putative 0.0047 0.0036 0.0835
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Schistosoma mansoni lamin 0.008 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0517 0.051 0.0509
Brugia malayi Cytochrome P450 family protein 0.0039 0.0027 0.0309
Brugia malayi putative neuropeptide receptor NPR1 0.0179 0.0169 0.1934
Echinococcus granulosus peptide allatostatin:somatostatin 0.0179 0.0169 0.0168
Entamoeba histolytica hypothetical protein 0.0114 0.0103 0.0101
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0022 0.0507
Brugia malayi CXXC zinc finger family protein 0.003 0.0018 0.0207
Echinococcus granulosus neuropeptides capa receptor 0.0179 0.0169 0.0168
Trichomonas vaginalis esterase, putative 0.0106 0.0095 0.2476
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0039 0.0027 0.0023
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0025 0.0023
Onchocerca volvulus 0.0146 0.0135 0.3553
Brugia malayi N-terminal motif family protein 0.0181 0.0171 0.1963
Trypanosoma cruzi Sphingosine kinase 0.0386 0.0378 1
Echinococcus multilocularis 0.0039 0.0027 0.0027
Brugia malayi Serotonin receptor 0.0179 0.0169 0.1934
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0064 0.1672
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0179 0.0169 0.0168
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0039 0.0027 0.0023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0462 0.0454 0.5212
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0031 0.003
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0031 0.0357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0078 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0078 0.0078
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0386 0.0378 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0015 0.0362
Plasmodium vivax diacylglycerol kinase, putative 0.0386 0.0378 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0039 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0386 0.0378 0.0376
Echinococcus multilocularis tar DNA binding protein 0.0207 0.0197 0.0197
Schistosoma mansoni neuropeptide receptor 0.0179 0.0169 0.0168
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0064 0.074
Brugia malayi Dopamine receptor protein 1 0.0179 0.0169 0.1934
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0014 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0078 0.0078
Echinococcus granulosus somatostatin receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) glutathione reductase 0.0047 0.0036 0.0034
Trichomonas vaginalis bmru protein, putative 0.0386 0.0378 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0179 0.0169 0.1934
Echinococcus granulosus biogenic amine 5HT receptor 0.0179 0.0169 0.0168
Echinococcus granulosus lamin 0.008 0.0069 0.0069
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0875 0.0872 0.087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0179 0.0169 0.0168
Brugia malayi ORL1-like opioid receptor 0.0179 0.0169 0.1934
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0022 0.0532
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0025 0.0024
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0097 0.8611
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0179 0.0169 0.0168
Loa Loa (eye worm) beta-lactamase 0.0106 0.0095 0.0093
Echinococcus granulosus 7tm_1 domain containing protein 0.0179 0.0169 0.0168
Echinococcus multilocularis geminin 0.0517 0.051 0.0509
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0179 0.0169 0.4438
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0039 0.0027 0.0023
Trypanosoma brucei trypanothione reductase 0.0047 0.0036 0.0902
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0022 0.0532
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0002 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0078 0.0078
Plasmodium falciparum glutathione reductase 0.0047 0.0036 0.0835
Schistosoma mansoni biogenic amine receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis neuropeptide s receptor 0.112 0.1119 0.1119
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0039 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Brugia malayi Dopamine receptor protein 2 0.0179 0.0169 0.1934
Loa Loa (eye worm) TAR-binding protein 0.0207 0.0197 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0197 0.0197
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0022 0.0461
Echinococcus granulosus serotonin receptor 0.0179 0.0169 0.0168
Echinococcus granulosus sex peptide receptor 0.0179 0.0169 0.0168
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0014 0.0334
Schistosoma mansoni neuropeptide receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0179 0.0169 0.0168
Brugia malayi hypothetical protein 0.0146 0.0135 0.1552
Brugia malayi hypothetical protein 0.0386 0.0378 0.4335
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0097 0.0092
Entamoeba histolytica hypothetical protein 0.0114 0.0103 0.0101
Plasmodium falciparum thioredoxin reductase 0.0047 0.0036 0.0835
Brugia malayi G protein-coupled receptor F59B2.13 0.0179 0.0169 0.1934
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0027 0.0613
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0676 0.0671 0.0667
Onchocerca volvulus 0.0179 0.0169 0.4438
Mycobacterium ulcerans beta-lactamase 0.0106 0.0095 0.009
Trichomonas vaginalis glutaminase, putative 0.0289 0.028 0.7395
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0179 0.0169 0.0168
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0025 0.0284
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0103 0.0103
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0002 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0146 0.0135 0.0135
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0014 0.0334
Loa Loa (eye worm) hypothetical protein 0.0049 0.0037 0.0036
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0027 1
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Mycobacterium tuberculosis Conserved protein 0.0106 0.0095 0.009
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0179 0.0169 0.0168
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0039 0.0027 0.0023
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0027 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0179 0.0169 0.0168
Trypanosoma brucei hypothetical protein, conserved 0.0386 0.0378 1
Schistosoma mansoni cpg binding protein 0.0032 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0095 0.2476
Plasmodium falciparum diacylglycerol kinase, putative 0.0386 0.0378 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Loa Loa (eye worm) hypothetical protein 0.0316 0.0307 0.0305
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0032 0.0032
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0179 0.0169 0.0168
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.008 0.0069 0.0067
Onchocerca volvulus 0.0386 0.0378 1
Echinococcus granulosus tm gpcr rhodopsin 0.0179 0.0169 0.0168
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0039 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0039 0.0027 0.0673
Schistosoma mansoni adenoreceptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Schistosoma mansoni sphingosine kinase A B 0.9914 1 1
Echinococcus granulosus GPCR family 2 0.0146 0.0135 0.0135
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0032 0.0032
Loa Loa (eye worm) TYRA-2 protein 0.0179 0.0169 0.0167
Echinococcus multilocularis neuropeptide FF receptor 2 0.0179 0.0169 0.0168
Brugia malayi hypothetical protein 0.012 0.0109 0.1249
Brugia malayi isocitrate dehydrogenase 0.0033 0.0022 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0179 0.0169 0.0168
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0097 0.0092
Brugia malayi neuropeptide F receptor 0.0179 0.0169 0.1934
Echinococcus granulosus biogenic amine 5HT receptor 0.0179 0.0169 0.0168
Onchocerca volvulus 0.0179 0.0169 0.4438
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.0095 0.009
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0025 0.0616
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0109 0.0104
Echinococcus granulosus Diacylglycerol kinase theta 0.0386 0.0378 0.0378
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0039 0.0027 0.0023
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0057 0.1477
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Echinococcus multilocularis fmrfamide receptor 0.0179 0.0169 0.0168
Trichomonas vaginalis bmru protein, putative 0.0386 0.0378 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Echinococcus multilocularis fmrfamide receptor 0.0179 0.0169 0.0168
Brugia malayi cytochrome P450 0.0039 0.0027 0.0309
Echinococcus multilocularis tumor protein p63 0.0335 0.0327 0.0326
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0078 0.0077
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.0095 0.2476
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0103 0.0103
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0027 0.0682
Schistosoma mansoni hypothetical protein 0.0146 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0179 0.0169 0.0168
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0027 1
Brugia malayi hypothetical protein 0.0114 0.0103 0.118
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0002 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0015 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Brugia malayi hypothetical protein 0.0027 0.0015 0.0175
Echinococcus granulosus fmrfamide receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.012 0.0109 0.0107
Loa Loa (eye worm) cytochrome P450 0.0039 0.0027 0.0025
Schistosoma mansoni opsin-like receptor 0.0179 0.0169 0.0168
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0386 0.0378 1
Loa Loa (eye worm) hypothetical protein 0.9914 1 1
Leishmania major cytochrome p450-like protein 0.0039 0.0027 0.0673
Onchocerca volvulus 0.0048 0.0036 0.092
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0025 0.0631
Entamoeba histolytica hypothetical protein 0.0114 0.0103 0.0101
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0014 0.0162
Schistosoma mansoni inositol monophosphatase 0.0037 0.0025 0.0025
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.0095 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0027 0.0682
Schistosoma mansoni biogenic amine (5HT) receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) cytochrome P450 family protein 0.0122 0.0111 0.011
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0039 0.0027 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0015 0.0362
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0002 0.0002
Plasmodium falciparum diacylglycerol kinase, putative 0.0386 0.0378 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0179 0.0169 0.0168
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0025 0.0616
Brugia malayi sulfakinin receptor protein 0.0179 0.0169 0.1934
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0057 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0039 0.0027 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Echinococcus multilocularis serotonin receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.0095 0.009
Brugia malayi hypothetical protein 0.0235 0.0225 0.2581
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.0171 0.4505
Schistosoma mansoni inositol monophosphatase 0.0037 0.0025 0.0025
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0092 0.0092
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0386 0.0378 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0022 0.0532
Loa Loa (eye worm) ceramide kinase 0.0386 0.0378 0.0376
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Mycobacterium ulcerans glutaminase 0.0289 0.028 0.0276
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0179 0.0169 0.0168
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0386 0.0378 0.0378
Brugia malayi intermediate filament protein 0.008 0.0069 0.0788
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0225 0.0225
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0014 0.0334
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0039 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Echinococcus multilocularis GPCR, family 2 0.0146 0.0135 0.0135
Echinococcus granulosus cpg binding protein 0.0032 0.002 0.002
Echinococcus granulosus g-protein coupled receptor 0.0179 0.0169 0.0168
Entamoeba histolytica diacylglycerol kinase, putative 0.0386 0.0378 0.0376
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0074
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0027 0.0613
Schistosoma mansoni cytochrome P450 0.0039 0.0027 0.0027
Brugia malayi Diacylglycerol kinase protein 2 0.0386 0.0378 0.4335
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0014 0.0014
Brugia malayi Thioredoxin reductase 0.0047 0.0036 0.0408
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0386 0.0378 0.0378
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0022 0.0021
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0022 0.0507
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0027 0.0682
Brugia malayi larval opioid receptor 0.0179 0.0169 0.1934
Echinococcus granulosus g protein coupled receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0025 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0078 0.0078
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0039 0.0027 0.0023
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0004 0.0048
Onchocerca volvulus 0.0179 0.0169 0.4438
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.0095 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0146 0.0135 0.0135
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0365 0.0356 0.0355
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0002 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0027 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0025 0.0616
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0064 0.0064
Leishmania major sphingosine kinase A, B, putative 0.0386 0.0378 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0074
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0064 0.1672
Leishmania major trypanothione reductase 0.0047 0.0036 0.0902
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0092 0.0092
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0064 0.1672
Echinococcus granulosus neuropeptide Y receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Echinococcus multilocularis sex peptide receptor 0.0179 0.0169 0.0168
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0002 0.0002
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0225 0.0225
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0021 0.0017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0027 0.0027
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.0095 0.2476
Brugia malayi glutaminase DH11.1 0.0289 0.028 0.3211
Schistosoma mansoni amine GPCR 0.0179 0.0169 0.0168
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0025 0.0025
Echinococcus granulosus neuropeptide receptor A26 0.112 0.1119 0.1119
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0022 0.0532
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0025 0.0631
Echinococcus granulosus dro:myosuppressin receptor 0.0179 0.0169 0.0168
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0014 0.0262
Echinococcus multilocularis allatostatin A receptor 0.0179 0.0169 0.0168
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.0095 0.009
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0027 0.0673
Brugia malayi AKH receptor 0.0179 0.0169 0.1934
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Leishmania major hypothetical protein, conserved 0.0027 0.0015 0.0362
Onchocerca volvulus 0.0179 0.0169 0.4438
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0036 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0179 0.0169 0.0168
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0057 0.0057
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0092 0.0092
Echinococcus granulosus intermediate filament protein 0.008 0.0069 0.0069
Mycobacterium ulcerans lipase LipD 0.0106 0.0095 0.009
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0179 0.0169 0.0168
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0037 0.0037
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0154 0.0153
Schistosoma mansoni hypothetical protein 0.0179 0.0169 0.0168
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0014 0.0002 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0025 0.0616
Loa Loa (eye worm) hypothetical protein 0.0146 0.0135 0.0134
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0027 0.0023
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0386 0.0378 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0146 0.0135 0.0135
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.0095 0.009
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0097 0.0092
Loa Loa (eye worm) glutaminase 0.0289 0.028 0.0278
Leishmania major cytochrome p450-like protein 0.0039 0.0027 0.0673
Mycobacterium ulcerans diacylglycerol kinase 0.0386 0.0378 0.0374
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0014 0.0309
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0014 0.0014
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0386 0.0378 0.0376
Brugia malayi Ceramide kinase 0.0386 0.0378 0.4335
Schistosoma mansoni opsin-like receptor 0.0179 0.0169 0.0168
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0027 0.0023
Trypanosoma cruzi Sphingosine kinase 0.0386 0.0378 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Echinococcus multilocularis neuropeptides capa receptor 0.0179 0.0169 0.0168
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0022 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0074
Trypanosoma cruzi diacylglycerol kinase, putative 0.0386 0.0378 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0027 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0109 1
Brugia malayi Eye-specific diacylglycerol kinase 0.0386 0.0378 0.4335
Schistosoma mansoni hypothetical protein 0.0039 0.0027 0.0027
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0179 0.0169 0.4438
Schistosoma mansoni biogenic amine receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0022 0.0021
Toxoplasma gondii thioredoxin reductase 0.0047 0.0036 0.0879
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0074
Toxoplasma gondii ABC1 family protein 0.0106 0.0095 0.2456
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0039 0.0027 0.0023
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0015 0.0338
Onchocerca volvulus Neuropeptide F receptor homolog 0.0179 0.0169 0.4438
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0039 0.0027 0.0023
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0039 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0106 0.0095 0.0093
Brugia malayi G-protein coupled receptor 0.0179 0.0169 0.1934
Onchocerca volvulus 0.0179 0.0169 0.4438
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0039 0.0027 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0179 0.0169 0.0167
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Plasmodium vivax hypothetical protein, conserved 0.0106 0.0095 0.242
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0179 0.0169 0.0168
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0027 0.0682
Schistosoma mansoni amine GPCR 0.0179 0.0169 0.0168
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0146 0.0135 0.0135
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0179 0.0169 0.0168
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0014 0.0014
Mycobacterium leprae conserved hypothetical protein 0.0106 0.0095 0.8393
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0039 0.0027 0.0023
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.0095 0.009
Loa Loa (eye worm) neuropeptide F receptor 0.0179 0.0169 0.0167
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0039 0.0027 0.0023
Onchocerca volvulus 0.0049 0.0037 0.0952
Echinococcus multilocularis rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0179 0.0169 0.0168
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0024
Mycobacterium ulcerans hypothetical protein 0.9914 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.0095 0.009
Loa Loa (eye worm) hypothetical protein 0.0181 0.0171 0.017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.0095 0.0095
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Onchocerca volvulus Huntingtin homolog 0.012 0.0109 0.2852
Echinococcus granulosus cytochrome P450 2K1 0.0039 0.0027 0.0027
Trypanosoma brucei glucosidase, putative 0.0037 0.0025 0.0616
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0039 0.0027 0.0023
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0179 0.0169 0.1934
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0004 0.0074
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.0095 0.0093
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0092 0.0092
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0039 0.0027 0.0023
Brugia malayi RNA binding protein 0.0207 0.0197 0.2258
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Schistosoma mansoni lamin 0.008 0.0069 0.0069
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0109 0.0104
Brugia malayi Calcitonin receptor-like protein seb-1 0.0462 0.0454 0.5212
Schistosoma mansoni hypothetical protein 0.0179 0.0169 0.0168
Entamoeba histolytica hypothetical protein, conserved 0.9914 1 1
Mycobacterium tuberculosis Probable reductase 0.0108 0.0097 0.0092
Echinococcus granulosus tachykinin peptides receptor 99D 0.0179 0.0169 0.0168
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0046 0.0045
Schistosoma mansoni amine GPCR 0.0179 0.0169 0.0168
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Brugia malayi Melibiase family protein 0.0069 0.0057 0.0656
Leishmania major hypothetical protein, conserved 0.0386 0.0378 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Echinococcus granulosus geminin 0.0517 0.051 0.0509
Echinococcus granulosus 7TM GPCR rhodopsin 0.0179 0.0169 0.0168
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0036 0.0415
Brugia malayi RNA recognition motif domain containing protein 0.0207 0.0197 0.2258
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0036 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0039 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Loa Loa (eye worm) hypothetical protein 0.0079 0.0067 0.0066
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.0095 0.009
Echinococcus multilocularis neuropeptide Y receptor 0.0179 0.0169 0.0168
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0179 0.0169 0.0167
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis sphingosine kinase 1 0.9914 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0025 0.0616
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0064 0.1672
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0025 0.0631
Trichomonas vaginalis chaperonin, putative 0.0026 0.0014 0.0334
Brugia malayi Tachykinin-like peptides receptor 99D 0.0179 0.0169 0.1934
Brugia malayi TAR-binding protein 0.0207 0.0197 0.2258
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0039 0.0027 0.0023
Echinococcus granulosus microtubule associated protein 2 0.0685 0.068 0.068
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0046 0.1188
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0103 0.0103
Brugia malayi Melatonin receptor type 1A 0.0179 0.0169 0.1934
Onchocerca volvulus 0.0095 0.0084 0.2193
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0027 0.0027
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0025 0.0023
Toxoplasma gondii diacylglycerol kinase, putative 0.0386 0.0378 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0025 0.0025
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0004 0.0074
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0039 0.0027 0.0023
Echinococcus granulosus neuropeptides capa receptor 0.0179 0.0169 0.0168
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0052 0.0052
Loa Loa (eye worm) melatonin receptor type 1A 0.0179 0.0169 0.0167
Loa Loa (eye worm) hypothetical protein 0.012 0.0109 0.0107
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0039 0.0027 0.0023
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0036 0.0835
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0002 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0179 0.0169 0.0168
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0386 0.0378 1
Leishmania major cytochrome p450-like protein 0.0058 0.0046 0.1188
Leishmania major diacylglycerol kinase-like protein 0.0386 0.0378 1
Schistosoma mansoni alpha glucosidase 0.0037 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0386 0.0378 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0025 0.0025
Echinococcus granulosus alpha 1A adrenergic receptor 0.0179 0.0169 0.0168
Mycobacterium tuberculosis Conserved protein 0.0106 0.0095 0.009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0074
Brugia malayi Inositol-1 0.0037 0.0025 0.0291
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0074
Mycobacterium ulcerans hypothetical protein 0.0106 0.0095 0.009
Trichomonas vaginalis sphingosine kinase, putative 0.0386 0.0378 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0039 0.0027 0.0023
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0064 0.0063
Echinococcus granulosus tumor protein p63 0.0335 0.0327 0.0326
Brugia malayi G-protein coupled receptor 0.0179 0.0169 0.1934
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0092 0.0092
Schistosoma mansoni alpha-glucosidase 0.0142 0.0131 0.0131
Echinococcus multilocularis neuropeptide receptor 0.0179 0.0169 0.0168
Schistosoma mansoni neuropeptide F-like receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0154 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.0095 0.2476
Onchocerca volvulus 0.008 0.0069 0.1782
Schistosoma mansoni growth hormone secretagogue receptor 0.0179 0.0169 0.0168
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0004 0.0074
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0022 0.0248
Brugia malayi putative neuropeptide receptor 0.0179 0.0169 0.1934
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0179 0.0169 0.0168
Brugia malayi follicle stimulating hormone receptor 0.0875 0.0872 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0078 0.0078
Brugia malayi beta-lactamase family protein 0.0106 0.0095 0.1087
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0106 0.0095 0.0093
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.0095 0.009
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0027 0.0682
Entamoeba histolytica hypothetical protein 0.0114 0.0103 0.0101
Brugia malayi diacylglycerol kinase 0.0386 0.0378 0.4335
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0039 0.0027 0.0673
Echinococcus multilocularis lamin 0.008 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Brugia malayi glutathione reductase 0.0047 0.0036 0.0408
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0179 0.0169 0.0168
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0025 0.9162
Schistosoma mansoni ap endonuclease 0.0039 0.0027 0.0027
Schistosoma mansoni neuropeptide receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis G-protein coupled receptor, putative 0.0179 0.0169 0.0168
Onchocerca volvulus 0.0179 0.0169 0.4438
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0039 0.0027 0.0023
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0004 0.0074
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Loa Loa (eye worm) hypothetical protein 0.0146 0.0135 0.0134
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0036 0.0035
Onchocerca volvulus 0.0106 0.0095 0.2476
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0015 0.0291
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0004 0.005
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0092 0.0092
Mycobacterium leprae Conserved hypothetical protein 0.0039 0.0027 0.0632
Brugia malayi hypothetical protein 0.0179 0.0169 0.1934
Echinococcus multilocularis neuropeptide receptor 0.0179 0.0169 0.0168
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0069 0.0788
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0146 0.0135 0.1554
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0015 0.0291
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0025 0.0616
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0014 0.0334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0179 0.0169 0.0168
Schistosoma mansoni amine GPCR 0.0179 0.0169 0.0168
Brugia malayi Cytochrome P450 family protein 0.0058 0.0046 0.0531
Brugia malayi Cytochrome P450 family protein 0.0122 0.0111 0.1276
Echinococcus granulosus allatostatin A receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0002 0.0002
Brugia malayi beta-lactamase 0.0106 0.0095 0.1087
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2466 0.2478 0.2478
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0003 0.0002
Plasmodium vivax diacylglycerol kinase, putative 0.0386 0.0378 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0025 0.0021
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0004 0.5
Loa Loa (eye worm) hypothetical protein 0.0106 0.0095 0.0093
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0022 0.0021
Onchocerca volvulus 0.0106 0.0095 0.2476
Echinococcus granulosus rhodopsin orphan GPCR 0.0179 0.0169 0.0168
Echinococcus granulosus G protein coupled receptor 139 0.0179 0.0169 0.0168
Echinococcus granulosus neuropeptide s receptor 0.112 0.1119 0.1119
Entamoeba histolytica diacylglycerol kinase, putative 0.0386 0.0378 0.0376
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0027 0.0673
Schistosoma mansoni hypothetical protein 0.0316 0.0307 0.0307
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0025 0.0592
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0106 0.0105
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0092 0.0092
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0039 0.0027 0.0023
Schistosoma mansoni neuropeptide F-like receptor 0.0179 0.0169 0.0168
Schistosoma mansoni neuropeptide receptor 0.0179 0.0169 0.0168
Onchocerca volvulus 0.0179 0.0169 0.4438
Leishmania major hypothetical protein, conserved 0.0106 0.0095 0.2476
Loa Loa (eye worm) G-protein coupled receptor 0.0179 0.0169 0.0167
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0002 0.0002
Echinococcus granulosus tar DNA binding protein 0.0207 0.0197 0.0197
Schistosoma mansoni ap endonuclease 0.0039 0.0027 0.0027
Schistosoma mansoni glutaminase 0.0289 0.028 0.028
Entamoeba histolytica diacylglycerol kinase, putative 0.0386 0.0378 0.0376
Echinococcus multilocularis lamin dm0 0.008 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0179 0.0169 0.0167
Onchocerca volvulus Ceramide kinase 1 homolog 0.0386 0.0378 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0022 0.0021
Loa Loa (eye worm) G-protein coupled receptor 0.0179 0.0169 0.0167
Brugia malayi Latrophilin receptor protein 2 0.0146 0.0135 0.1554
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0025 0.0616
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0179 0.0169 0.1934
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Brugia malayi Dopamine receptor 0.0179 0.0169 0.1934
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0039 0.0027 0.0023
Schistosoma mansoni opsin-like receptor 0.0179 0.0169 0.0168
Schistosoma mansoni biogenic amine receptor 0.0179 0.0169 0.0168
Onchocerca volvulus 0.0179 0.0169 0.4438
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0022 0.0017
Onchocerca volvulus 0.008 0.0069 0.1782
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.068 0.068
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0064 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0179 0.0169 0.0168
Onchocerca volvulus Huntingtin homolog 0.012 0.0109 0.2852
Mycobacterium leprae Probable lipase LipE 0.0106 0.0095 0.8393
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0179 0.0169 0.0168
Echinococcus granulosus orexin receptor type 2 0.0179 0.0169 0.0168
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0025 0.0631
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0022 0.0461
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0197 0.0197
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0014 0.0013
Echinococcus granulosus tm gpcr rhodopsin 0.0179 0.0169 0.0168
Loa Loa (eye worm) intermediate filament protein 0.008 0.0069 0.0067
Leishmania major diacylglycerol kinase, putative 0.0386 0.0378 1
Leishmania major hypothetical protein, conserved 0.0386 0.0378 1
Brugia malayi latrophilin 2 splice variant baaae 0.0316 0.0307 0.3519
Echinococcus multilocularis cpg binding protein 0.0032 0.002 0.002
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0386 0.0378 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0024
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0179 0.0169 0.0168
Brugia malayi Serotonin receptor 0.0179 0.0169 0.1934
Schistosoma mansoni biogenic amine (5HT) receptor 0.0179 0.0169 0.0168
Schistosoma mansoni hypothetical protein 0.0517 0.051 0.0509
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0074
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0022 0.002
Schistosoma mansoni hypothetical protein 0.0114 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0106 0.0095 0.0093
Echinococcus granulosus neuropeptide receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.068 0.068
Echinococcus multilocularis g protein coupled receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Echinococcus multilocularis neuropeptide Y receptor 0.0179 0.0169 0.0168
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0179 0.0169 0.0168
Loa Loa (eye worm) glutaminase 2 0.0289 0.028 0.0278
Echinococcus granulosus Diacylglycerol kinase zeta 0.0386 0.0378 0.0378
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0025 0.0616
Onchocerca volvulus 0.0179 0.0169 0.4438
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0197 0.0197
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0179 0.0169 0.0168
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0386 0.0378 0.0378
Onchocerca volvulus 0.0179 0.0169 0.4438
Schistosoma mansoni survival motor neuron protein 0.0048 0.0036 0.0036
Trypanosoma brucei cytochrome P450, putative 0.0058 0.0046 0.1188
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0064 0.0064
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0014 0.4273
Schistosoma mansoni histamine h1 receptor 0.0179 0.0169 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0179 0.0169 0.0168
Schistosoma mansoni alpha-1 adrenergic receptor 0.0179 0.0169 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0355 0.0346 0.9155
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0154 0.0154
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0002 0.0002
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0386 0.0378 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0074
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0078 0.09
Trichomonas vaginalis conserved hypothetical protein 0.0386 0.0378 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0039 0.0027 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0179 0.0169 0.0168
Loa Loa (eye worm) latrophilin receptor protein 2 0.0146 0.0135 0.0134
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0064 0.0064
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0025 0.0023
Echinococcus granulosus neuropeptide FF receptor 2 0.0179 0.0169 0.0168
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0207 0.0197 0.0195
Echinococcus multilocularis somatostatin receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0179 0.0169 0.0167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0179 0.0169 0.0168
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0025 0.0631
Echinococcus multilocularis orexin receptor type 2 0.0179 0.0169 0.0168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.0095 0.0095
Entamoeba histolytica diacylglycerol kinase, putative 0.0386 0.0378 0.0376
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0046 0.0045
Brugia malayi hypothetical protein 0.0018 0.0006 0.0064
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0109 0.0104
Onchocerca volvulus 0.0179 0.0169 0.4438
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0386 0.0378 0.0378
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0002 0.0002
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0002 0.0002
Brugia malayi diacylglycerol kinase 0.0386 0.0378 0.4335
Mycobacterium tuberculosis Diacylglycerol kinase 0.0386 0.0378 0.0374
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0039 0.0027 0.0023
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0002 0.0002
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0179 0.0169 0.1934
Mycobacterium tuberculosis Conserved protein 0.9914 1 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0039 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0074
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0154 0.0154
Echinococcus granulosus g protein coupled receptor 0.0179 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0179 0.0169 0.0167

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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