Detailed information for compound 57734

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.494 | Formula: C21H25NO2S
  • H donors: 3 H acceptors: 2 LogP: 4.44 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc2CC[C@H]3[C@H](c2cc1O)c1cc(sc1CN3)C1CCCCC1
  • InChi: 1S/C21H25NO2S/c23-17-8-13-6-7-16-21(14(13)9-18(17)24)15-10-19(25-20(15)11-22-16)12-4-2-1-3-5-12/h8-10,12,16,21-24H,1-7,11H2/t16-,21+/m0/s1
  • InChiKey: AWCWQIFJWRNJCA-HRAATJIYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Carassius auratus Dopamine D1 receptor Starlite/ChEMBL References
Rattus norvegicus Dopamine D1 receptor Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_134111 All targets in OG5_134111
Brugia malayi Dopamine receptor protein 1 Get druggable targets OG5_134111 All targets in OG5_134111
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Dopamine D1 receptor   363 aa 329 aa 28.3 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Dopamine D1 receptor   363 aa 301 aa 22.6 %
Loa Loa (eye worm) follicle stimulating hormone receptor Dopamine D1 receptor   363 aa 317 aa 20.5 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Dopamine D1 receptor   363 aa 354 aa 27.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Dopamine D1 receptor   446 aa 394 aa 29.9 %
Echinococcus granulosus neuropeptide receptor Dopamine D1 receptor   363 aa 338 aa 25.7 %
Schistosoma mansoni adenoreceptor Dopamine D1 receptor   363 aa 358 aa 29.9 %
Schistosoma mansoni peptide (allatostatin)-like receptor Dopamine D1 receptor   363 aa 344 aa 24.1 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Onchocerca volvulus Dopamine D1 receptor   363 aa 367 aa 32.2 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Dopamine D1 receptor   363 aa 364 aa 29.4 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Dopamine D1 receptor   363 aa 346 aa 24.6 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D2 receptor   444 aa 476 aa 24.2 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   363 aa 326 aa 28.2 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D1 receptor   446 aa 373 aa 25.5 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Dopamine D1 receptor   363 aa 389 aa 20.3 %
Onchocerca volvulus Dopamine D1 receptor   363 aa 300 aa 25.3 %
Echinococcus granulosus thyrotropin releasing hormone receptor Dopamine D1 receptor   363 aa 354 aa 27.7 %
Onchocerca volvulus Dopamine D1 receptor   363 aa 313 aa 24.6 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.0 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   446 aa 370 aa 24.9 %
Echinococcus multilocularis orexin receptor type 2 Dopamine D1 receptor   363 aa 340 aa 23.8 %
Onchocerca volvulus Dopamine D1 receptor   363 aa 352 aa 37.5 %
Brugia malayi GnHR receptor homolog Dopamine D1 receptor   363 aa 318 aa 21.7 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.1 %
Echinococcus multilocularis allatostatin A receptor Dopamine D1 receptor   363 aa 325 aa 23.1 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D1 receptor   446 aa 366 aa 35.2 %
Onchocerca volvulus Mitogen-activated protein kinase kinase kinase 8 homolog Dopamine D1 receptor   363 aa 341 aa 23.2 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Dopamine D1 receptor   363 aa 362 aa 32.0 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Onchocerca volvulus Dopamine D1 receptor   363 aa 332 aa 25.6 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Dopamine D1 receptor   363 aa 386 aa 27.7 %
Onchocerca volvulus Dopamine D1 receptor   363 aa 408 aa 28.4 %
Echinococcus granulosus allatostatin A receptor Dopamine D1 receptor   363 aa 320 aa 22.8 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Echinococcus multilocularis neuropeptide receptor Dopamine D1 receptor   363 aa 341 aa 25.2 %
Onchocerca volvulus Dopamine D1 receptor   363 aa 307 aa 24.1 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 418 aa 23.0 %
Onchocerca volvulus Dopamine D1 receptor   446 aa 357 aa 21.0 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Loa Loa (eye worm) neuropeptide F receptor Dopamine D1 receptor   363 aa 347 aa 23.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine D1 receptor   446 aa 407 aa 33.7 %
Schistosoma japonicum Rhodopsin, putative Dopamine D1 receptor   363 aa 365 aa 26.3 %
Brugia malayi follicle stimulating hormone receptor Dopamine D1 receptor   363 aa 309 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0013 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0049 0.0127
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0013 0.0047
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0306 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0306 1
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0013 0.0047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0346 0.0799
Trichomonas vaginalis DNA helicase recq, putative 0.0035 0.0058 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0001 0.0002
Mycobacterium tuberculosis Possible hydrolase 0.0019 0.0011 0.0022
Brugia malayi neuropeptide F receptor 0.0016 0.0001 0.0003
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0024 0.0027 0.01
Schistosoma mansoni loxhd1 0.0023 0.0022 0.0052
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0001 0.0003
Brugia malayi hypothetical protein 0.0043 0.0083 0.0308
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0008 0.0008
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Brugia malayi ecdysteroid receptor 0.002 0.0013 0.0047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0001 0.0002
Schistosoma mansoni polycystin 1-related 0.0023 0.0022 0.0052
Onchocerca volvulus 0.0023 0.0022 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0001 0.0001
Brugia malayi metabotropic glutamate receptor type 2 0.0046 0.0093 0.0346
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0067 0.1128
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0058 0.0856
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0008 0.003
Brugia malayi hypothetical protein 0.0025 0.0027 0.0103
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0032 0.0973
Onchocerca volvulus 0.0052 0.011 0.036
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0003 0.0008
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0001 0.0001
Echinococcus granulosus aminopeptidase N 0.0026 0.0032 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0013 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0083 0.0238
Schistosoma mansoni nAChR subunit 0.0018 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0099 0.0251 0.0937
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0001 0.0001
Schistosoma mansoni biogenic amine receptor 0.0016 0.0001 0.0002
Onchocerca volvulus 0.0016 0.0001 0.0002
Echinococcus granulosus allatostatin A receptor 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0017 0.0003 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0013 0.0013
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Giardia lamblia Hypothetical protein 0.0019 0.0011 0.0096
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.2 0.5956 1
Schistosoma mansoni survival motor neuron protein 0.0052 0.011 0.0253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0001 0.0002
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0022 0.0617
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Schistosoma mansoni hypothetical protein 0.0786 0.2314 0.5335
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0001 0.0001
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0008 0.0008
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0001 0.0003
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0001 0.0003
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0032 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0062 0.0139 0.4345
Echinococcus granulosus lamin dm0 0.0119 0.0312 0.0312
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0019 0.0011 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0001 0.0001
Brugia malayi Cache domain containing protein 0.0674 0.1977 0.7383
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0001 0.0003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0001 0.0003
Loa Loa (eye worm) PXA domain-containing protein 0.0043 0.0083 0.0308
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0193 0.3252
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0062 0.0139 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0206 0.0573 1
Brugia malayi Zona pellucida-like domain containing protein 0.0062 0.014 0.0524
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0306 0.5246
Schistosoma mansoni amine GPCR 0.0016 0.0001 0.0002
Echinococcus granulosus transcription factor Dp 1 0.004 0.0073 0.0073
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0001 0.0002
Onchocerca volvulus 0.0062 0.014 0.046
Brugia malayi GnHR receptor homolog 0.0016 0.0001 0.0003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0008 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0346 0.0799
Entamoeba histolytica hypothetical protein, conserved 0.0062 0.014 0.4575
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0058 0.0127 0.0473
Brugia malayi intermediate filament protein 0.0119 0.0312 0.1166
Toxoplasma gondii aldehyde dehydrogenase 0.0206 0.0573 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0026 0.0032 0.0121
Plasmodium vivax thrombospondin-related anonymous protein 0.0062 0.014 0.4035
Echinococcus multilocularis neurogenic locus notch protein 0.005 0.0103 0.0103
Onchocerca volvulus 0.0062 0.014 0.046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Brugia malayi Protein kinase domain containing protein 0.0026 0.0031 0.0114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0043
Toxoplasma gondii endonuclease IV APN 0.008 0.0193 0.3338
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0026 0.0031 0.01
Brugia malayi hypothetical protein 0.0272 0.0771 0.2881
Brugia malayi Sulfatase family protein 0.0019 0.0011 0.0043
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Echinococcus granulosus neurogenic locus notch protein 0.005 0.0103 0.0103
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0008 0.0008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0013 0.0013
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0073 0.493
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0008 0.0008
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0019 0.0011 0.0004
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0049 0.1382
Brugia malayi CXXC zinc finger family protein 0.0033 0.0054 0.0201
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0008 0.003
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3348 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0001 0.0001
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0001 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0013 0.0029
Plasmodium falciparum cysteine repeat modular protein 1 0.0026 0.0031 0.0477
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0306 0.1141
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0131 0.0346 0.0799
Brugia malayi hypothetical protein 0.0016 0.0001 0.0005
Onchocerca volvulus 0.0016 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0146 0.0392 0.0903
Schistosoma mansoni gabp alpha 0.0071 0.0165 0.0382
Schistosoma mansoni myosin xvIII 0.0016 0.0001 0.0002
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0001 0.0001
Schistosoma mansoni rab6-interacting 0.0023 0.0022 0.0052
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0139 0.6795
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0013
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0049 0.1382
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0001 0.0002
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0067 0.2174
Onchocerca volvulus 0.0017 0.0003 0.0011
Echinococcus granulosus axis inhibition protein axin 0.0043 0.0083 0.0083
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0026 0.0032 0.0586
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0119 0.0312 0.1166
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0008 0.003
Entamoeba histolytica recQ family DNA helicase 0.0016 0.0003 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0049 0.1547
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0001 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0001 0.0002
Onchocerca volvulus 0.0016 0.0001 0.0002
Schistosoma mansoni serine-rich repeat protein 0.0786 0.2314 0.5335
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus multilocularis RUN 0.0023 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.001 0.0299
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0001 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0157 0.271
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0017 0.0055
Brugia malayi hypothetical protein 0.0062 0.014 0.0524
Schistosoma mansoni axis inhibition protein axin 0.0043 0.0083 0.019
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0001 0.0001
Schistosoma mansoni adenoreceptor 0.0016 0.0001 0.0002
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0008 0.003
Schistosoma mansoni coup transcription factor 0.002 0.0013 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0083 0.0238
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0117 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Brugia malayi Cation transporter family protein 0.0018 0.0008 0.003
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0083 0.019
Loa Loa (eye worm) hypothetical protein 0.0119 0.0312 0.1166
Echinococcus multilocularis expressed protein 0.0835 0.246 0.246
Brugia malayi G-protein coupled receptor 0.0016 0.0001 0.0003
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0008 0.0008
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.016 0.2662
Echinococcus multilocularis musashi 0.0119 0.0312 0.0312
Brugia malayi von Willebrand factor type A domain containing protein 0.0062 0.014 0.0524
Echinococcus multilocularis lamin dm0 0.0119 0.0312 0.0312
Schistosoma mansoni aldehyde dehydrogenase 0.0206 0.0573 0.1322
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0008 0.0008
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0001 0.0002
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0099 0.0251 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0083 0.0238
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0026 0.0032 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0013 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0239
Echinococcus granulosus geminin 0.0196 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0013 0.0047
Echinococcus granulosus neuropeptide receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0049 0.0077
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0306 0.5246
Onchocerca volvulus 0.0016 0.0001 0.0002
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0165 0.0165
Schistosoma mansoni nAChR subunit 0.0018 0.0008 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0139 0.3981
Loa Loa (eye worm) hypothetical protein 0.071 0.2084 0.7785
Entamoeba histolytica hypothetical protein 0.0062 0.014 0.4575
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.005 0.0188
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0001 0.0003
Brugia malayi sulfakinin receptor protein 0.0016 0.0001 0.0003
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0008 0.0018
Onchocerca volvulus 0.0017 0.0003 0.0011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0125 0.033 0.033
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0383 0.1105 0.1105
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0013 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0131 0.0346 0.1293
Brugia malayi A-kinase anchor protein 10, precursor 0.0043 0.0083 0.0308
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Echinococcus granulosus dnaJ subfamily B 0.0474 0.1377 0.1377
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0306 0.0508
Brugia malayi Pre-SET motif family protein 0.0131 0.0346 0.1293
Echinococcus granulosus sex peptide receptor 0.0016 0.0001 0.0001
Trypanosoma brucei Aminopeptidase M1, putative 0.0026 0.0032 0.0752
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.01
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.0083 0.0083
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0073 0.0169
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0032 0.0973
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1523 0.4523 0.4523
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0013
Brugia malayi steroid hormone receptor 0.002 0.0013 0.0047
Trichomonas vaginalis set domain proteins, putative 0.1033 0.3053 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0008 0.003
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0019 0.0011 0.0022
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.0392 0.0392
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0073 0.0073
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0108 0.0277 0.064
Brugia malayi putative neuropeptide receptor 0.0016 0.0001 0.0003
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0049 0.1568
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.0719 0.0719
Loa Loa (eye worm) TK/ROR protein kinase 0.0026 0.0031 0.0114
Schistosoma mansoni nAChR subunit 0.0018 0.0008 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0346 0.0799
Echinococcus granulosus expressed protein 0.0835 0.246 0.246
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0049 0.0127
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0001 0.0001
Onchocerca volvulus Putative nachr subunit 0.0018 0.0008 0.0026
Toxoplasma gondii aminopeptidase N protein 0.0026 0.0032 0.0516
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.005 0.083
Toxoplasma gondii kringle domain-containing protein 0.0026 0.0031 0.0484
Toxoplasma gondii aminopeptidase n, putative 0.0026 0.0032 0.0516
Trichomonas vaginalis rotamase, putative 0.0038 0.0067 0.0188
Onchocerca volvulus 0.0016 0.0001 0.0002
Loa Loa (eye worm) CUTiclin-Like family member 0.0062 0.014 0.0524
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0073 0.233
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.2674
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0013 0.0047
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0049 0.0804
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0032 0.005 0.0188
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0001 0.0001
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0022 0.0022
Toxoplasma gondii microneme protein MIC17C 0.0017 0.0003 0.0008
Toxoplasma gondii aminopeptidase N, putative 0.0026 0.0032 0.0516
Treponema pallidum 76K protein 0.0062 0.014 0.0231
Echinococcus granulosus voltage dependent calcium channel subunit 0.1523 0.4523 0.4523
Loa Loa (eye worm) hypothetical protein 0.0255 0.0719 0.2686
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0131 0.0346 0.6022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0011
Onchocerca volvulus 0.0017 0.0003 0.0011
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0089 0.026
Schistosoma mansoni hypothetical protein 0.0196 0.0543 0.1253
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0062 0.014 0.0524
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni z-protein (S1r protein) 0.0043 0.0083 0.019
Toxoplasma gondii subtilisin SUB12 0.0017 0.0003 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0121
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0306 1
Brugia malayi Cation transporter family protein 0.0018 0.0008 0.003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0013 0.0013
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0001 0.0002
Onchocerca volvulus 0.0016 0.0001 0.0002
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Schistosoma mansoni thyroid hormone receptor 0.0166 0.045 0.1039
Toxoplasma gondii microneme protein MIC2 0.0062 0.014 0.241
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0008 0.003
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0062 0.014 0.6904
Plasmodium vivax SET domain protein, putative 0.0131 0.0346 1
Onchocerca volvulus 0.0017 0.0003 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Onchocerca volvulus 0.0016 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Echinococcus granulosus somatostatin receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0003 0.0013
Brugia malayi regulator of G-protein signaling egl-10 0.0043 0.0083 0.0308
Echinococcus multilocularis aminopeptidase N 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0013 0.0013
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Onchocerca volvulus 0.1033 0.3053 1
Onchocerca volvulus 0.0023 0.0022 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0083 0.0238
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0017 0.0063
Brugia malayi larval opioid receptor 0.0016 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0084
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0008 0.0008
Echinococcus multilocularis cpg binding protein 0.0035 0.0059 0.0059
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0001 0.0001
Echinococcus granulosus neuropeptide receptor 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0018 0.0008 0.0026
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0306 0.0306
Brugia malayi von Willebrand factor type A domain containing protein 0.0062 0.014 0.0524
Schistosoma mansoni hypothetical protein 0.0062 0.014 0.0324
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0026 0.0032 0.0032
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0032 0.0394
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0022 0.0022
Brugia malayi TATA binding protein associated factor 0.0026 0.0032 0.0121
Onchocerca volvulus 0.0017 0.0003 0.0011
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Trichomonas vaginalis rotamase, putative 0.0039 0.007 0.0197
Echinococcus granulosus g protein coupled receptor 0.0016 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0083 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0001 0.0002
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0032 0.0907
Loa Loa (eye worm) CUTiclin family member 0.0062 0.014 0.0524
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0001 0.0001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.014 0.0524
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0103
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0003 0.0013
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0073 0.0208
Schistosoma mansoni aminopeptidase A (M01 family) 0.0026 0.0032 0.0075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0062 0.0139 0.448
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0043 0.0083 0.0308
Onchocerca volvulus 0.0062 0.014 0.046
Entamoeba histolytica elongation factor-2 kinase, putative 0.0062 0.014 0.4575
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0062 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Brugia malayi 6-phosphofructokinase 0.0117 0.0306 0.1141
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0131 0.0346 0.0346
Brugia malayi Ets-domain containing protein 0.0071 0.0165 0.0618
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0032 0.0907
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0306 0.0971
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0001 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0038
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.2674
Entamoeba histolytica aminopeptidase, putative 0.0026 0.0032 0.1028
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni metabotropic glutamate receptor 0.0079 0.0192 0.0443
Schistosoma mansoni neuropeptide receptor 0.0016 0.0001 0.0002
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0032 0.0973
Onchocerca volvulus 0.0017 0.0003 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0008 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0206 0.0573 0.1322
Onchocerca volvulus 0.0119 0.0312 0.1022
Echinococcus multilocularis regulator of G protein signaling 3 0.0043 0.0083 0.0083
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0008 0.0008
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.005 0.0188
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0099 0.0251 0.0251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0001 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0206 0.0573 0.0573
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Brugia malayi cytoplasmic intermediate filament protein 0.0064 0.0146 0.0544
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0062 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0052 0.011 0.0253
Loa Loa (eye worm) aminopeptidase N 0.0026 0.0032 0.0121
Echinococcus granulosus metabotropic glutamate receptor 2 0.0079 0.0192 0.0192
Chlamydia trachomatis endonuclease IV 0.008 0.0193 1
Brugia malayi EGF-like domain containing protein 0.005 0.0103 0.0386
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Onchocerca volvulus 0.0016 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.0016 0.0001 0.0002
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.001 0.0239
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0049 0.0127
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.2674
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.001 0.0024
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0003 0.0013
Onchocerca volvulus 0.0018 0.0008 0.0026
Toxoplasma gondii microneme protein MIC17A 0.0017 0.0003 0.0008
Brugia malayi follicle stimulating hormone receptor 0.0264 0.0745 0.2783
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0013 0.0013
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0062 0.014 0.6904
Mycobacterium ulcerans epimerase 0.0021 0.0017 0.0117
Brugia malayi PXA domain containing protein 0.0043 0.0083 0.0308
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni DNA helicase recq1 0.0032 0.005 0.0116
Toxoplasma gondii microneme protein MIC17B 0.0017 0.0003 0.0008
Mycobacterium tuberculosis Probable sulfatase 0.0019 0.0011 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0049 0.0127
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0062 0.014 0.4035
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0306 0.0705
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Brugia malayi von Willebrand factor type A domain containing protein 0.0062 0.014 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0013 0.0047
Echinococcus multilocularis axis inhibition protein axin 0.0043 0.0083 0.0083
Echinococcus granulosus slit 2 protein 0.005 0.0103 0.0103
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0008 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0049 0.0127
Giardia lamblia Hypothetical protein 0.0019 0.0011 0.0096
Onchocerca volvulus 0.0016 0.0001 0.0002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0013 0.0029
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0083 0.019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0308
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0049 0.0127
Echinococcus granulosus g protein coupled receptor 0.0016 0.0001 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0001 0.0001
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0073 0.0073
Mycobacterium ulcerans arylsulfatase AtsD 0.0019 0.0011 0.0022
Brugia malayi ORL1-like opioid receptor 0.0016 0.0001 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0001 0.0001
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0003 0.0013
Brugia malayi neuropeptide F receptor 0.0016 0.0001 0.0003
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0032 0.005 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0026 0.0031 0.007
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0043 0.0083 0.0238
Schistosoma mansoni ap endonuclease 0.0062 0.0139 0.0319
Onchocerca volvulus 0.0062 0.014 0.046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0032 0.005 0.005
Schistosoma mansoni laminin gamma-3 chain 0.005 0.0103 0.0238
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0306 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0099 0.0251 0.0579
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0008 0.003
Brugia malayi Metabotropic glutamate receptor precursor. 0.0095 0.0238 0.0891
Brugia malayi hypothetical protein 0.0227 0.0634 0.2368
Echinococcus granulosus lamin 0.0119 0.0312 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0083 0.0238
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0032 0.0121
Loa Loa (eye worm) hypothetical protein 0.006 0.0135 0.0503
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0001 0.0001
Echinococcus multilocularis lamin 0.0119 0.0312 0.0312
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0083 0.019
Schistosoma mansoni cpg binding protein 0.0035 0.0059 0.0137
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0032 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0033 0.0054 0.0176
Onchocerca volvulus 0.0018 0.0008 0.0026
Echinococcus granulosus pikachurin 0.005 0.0103 0.0103
Echinococcus multilocularis thyroid hormone receptor alpha 0.0166 0.045 0.045
Echinococcus granulosus beta-adrenergic receptor kinase 0.0043 0.0083 0.0083
Schistosoma mansoni lipoxygenase 0.0023 0.0022 0.0052
Brugia malayi Ets-domain containing protein 0.0071 0.0165 0.0618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0013
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0032 0.0394
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0165 0.0165
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0001 0.0001
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0073 0.2377
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0131 0.0346 0.0346
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0001 0.0002
Brugia malayi hypothetical protein 0.0019 0.0011 0.0043
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0032 0.0394
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0008 0.0008
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.016 0.0598
Loa Loa (eye worm) hypothetical protein 0.0055 0.012 0.0449
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0001 0.0003
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0008 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.0075 0.0179 0.0669
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0013 0.0047
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0032 0.0394
Echinococcus granulosus histone lysine methyltransferase setb 0.0131 0.0346 0.0346
Trypanosoma cruzi Aminopeptidase M1, putative 0.0026 0.0032 0.0973
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0001 0.0002
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0383 0.1105 0.4126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0008 0.003
Onchocerca volvulus 0.0017 0.0003 0.0011
Onchocerca volvulus 0.0062 0.014 0.046
Brugia malayi hypothetical protein 0.0026 0.0032 0.0121
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.018 0.0415
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0013 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0297
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Echinococcus multilocularis axis inhibition protein axin 0.0043 0.0083 0.0083
Echinococcus granulosus dna polymerase eta 0.0019 0.001 0.001
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0058 0.1631
Brugia malayi von Willebrand factor type A domain containing protein 0.0062 0.014 0.0524
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0008 0.003
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.016 0.5221
Schistosoma mansoni nuclear hormone receptor 0.002 0.0013 0.0029
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0001 0.0001
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.007 0.0261
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0073 0.233
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0013
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0073 0.2142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0013 0.0047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0907 0.2677 1
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0022 0.0084
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0001 0.0003
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.016 0.0369
Schistosoma mansoni DNA polymerase eta 0.0019 0.001 0.0024
Onchocerca volvulus 0.0016 0.0001 0.0002
Echinococcus granulosus g protein coupled receptor 0.0016 0.0001 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0013 0.0047
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) TATA binding protein associated factor 0.0026 0.0032 0.0121
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0032 0.0073
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.0719 0.0719
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0206 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0308
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0008 0.0008
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0306 0.1141
Echinococcus multilocularis somatostatin receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) glutamate receptor 0.0095 0.0238 0.0891
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.0027 0.01
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0002
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0003 0.0008
Loa Loa (eye worm) glutamate receptor 0.0037 0.0066 0.0246
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0001 0.0001
Schistosoma mansoni rotamase 0.0039 0.007 0.0161
Brugia malayi Cation transporter family protein 0.0018 0.0008 0.003
Echinococcus granulosus fmrfamide receptor 0.0016 0.0001 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0013 0.0029
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0062 0.0139 0.0139
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0062 0.014 0.0524
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0003 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0027 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0017 0.0117
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0001 0.0002
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0073 0.0169
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.0083 0.0083
Loa Loa (eye worm) RecQ helicase 0.0045 0.0089 0.0334
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0008 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0001 0.0002
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0067 0.1932
Schistosoma mansoni amine GPCR 0.0016 0.0001 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0013 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0013
Onchocerca volvulus 0.0016 0.0001 0.0002
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0736 0.2163 0.4988
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0008 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0206 0.0573 1
Loa Loa (eye worm) hypothetical protein 0.0674 0.1977 0.7383
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0306 0.1141
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.005 0.0103 0.0238
Brugia malayi Regulator of G protein signaling domain containing protein 0.0043 0.0083 0.0308
Onchocerca volvulus 0.0016 0.0001 0.0002
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0043 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0013 0.0047
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0306 1
Brugia malayi Intermediate filament tail domain containing protein 0.0119 0.0312 0.1166
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0049 0.0127
Schistosoma mansoni hypothetical protein 0.0196 0.0543 0.1253
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0073 0.0073
Schistosoma mansoni metabotropic glutamate receptor 0.0046 0.0093 0.0213
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0049 0.301
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0083 0.019
Brugia malayi von Willebrand Factor 0.0062 0.014 0.0524
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0062 0.0139 0.0517
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0073 0.0274
Toxoplasma gondii hypothetical protein 0.0017 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0013 0.0029
Brugia malayi Dopamine receptor protein 2 0.0016 0.0001 0.0003
Brugia malayi 6-phosphofructokinase 0.0117 0.0306 0.1141
Onchocerca volvulus 0.0119 0.0312 0.1022
Brugia malayi Pre-SET motif family protein 0.0907 0.2677 1
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0016 0.0001 0.0002
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0001 0.0003
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0032 0.0973
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) fli-1 protein 0.0214 0.0596 0.2228
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0306 0.0971
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0067 0.2125
Schistosoma mansoni axis inhibition protein axin 0.0043 0.0083 0.019
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0062 0.0139 0.2279
Onchocerca volvulus 0.0018 0.0008 0.0026
Echinococcus multilocularis sex peptide receptor 0.0016 0.0001 0.0001
Brugia malayi Regulator of G protein signaling domain containing protein 0.0043 0.0083 0.0308
Loa Loa (eye worm) hypothetical protein 0.0099 0.0251 0.0937
Mycobacterium ulcerans arylsulfatase AtsB 0.0019 0.0011 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0013 0.0047
Brugia malayi von Willebrand factor type A domain containing protein 0.0062 0.014 0.0524
Brugia malayi Doublecortin family protein 0.0023 0.0022 0.0084
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0032 0.0512
Plasmodium falciparum thrombospondin-related anonymous protein 0.0062 0.014 0.6904
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus multilocularis dna polymerase eta 0.0019 0.001 0.001
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.016 0.0598
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0083 0.019
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0001 0.0001
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0001 0.0001
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0008 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0139 0.0422
Brugia malayi Melatonin receptor type 1A 0.0016 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0013
Echinococcus granulosus dna polymerase kappa 0.0019 0.001 0.001
Echinococcus granulosus regulator of G protein signaling 3 0.0043 0.0083 0.0083
Schistosoma mansoni nAChR subunit 0.0018 0.0008 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.094 0.2775 0.2775
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0017 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0001 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0206 0.0573 1
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni lamin 0.0119 0.0312 0.072
Brugia malayi von Willebrand factor type A domain containing protein 0.0062 0.014 0.0524
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Brugia malayi nuclear hormone receptor 0.002 0.0013 0.0047
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0165 0.0618
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0067 0.1014
Echinococcus granulosus nAChR subunit 0.0018 0.0008 0.0008
Echinococcus multilocularis expressed protein 0.0039 0.007 0.007
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0383 0.1105 0.2547
Loa Loa (eye worm) hypothetical protein 0.0055 0.012 0.0449
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0089 0.026
Schistosoma mansoni neuropeptide receptor 0.0016 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0001 0.0001
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0001 0.0001
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0032 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0013 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0073 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Brugia malayi hypothetical protein 0.0023 0.0022 0.0084
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0062 0.0139 0.2279
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.081
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.016 0.016
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0001 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.081
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.146 0.4336 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0001 0.0002
Brugia malayi laminin alpha chain 0.005 0.0103 0.0386
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0027 0.0764
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0026 0.0031 0.0853
Echinococcus granulosus expressed protein 0.0039 0.007 0.007
Trypanosoma brucei Aminopeptidase M1, putative 0.0026 0.0032 0.0752
Onchocerca volvulus 0.0026 0.0032 0.0106
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0179 0.0669
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Mycobacterium ulcerans arylsulfatase, AslA 0.0019 0.0011 0.0022
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0024 0.0027 0.01
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Toxoplasma gondii microneme protein MIC4 0.0017 0.0003 0.0008
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0008 0.0008
Schistosoma mansoni neuropeptide receptor 0.0016 0.0001 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Brugia malayi von Willebrand factor type A domain containing protein 0.0062 0.014 0.0524
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) intermediate filament protein 0.0119 0.0312 0.1166
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0062 0.0139 0.2279
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0001 0.0001
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0008 0.0018
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0013 0.0041
Schistosoma mansoni cell polarity protein 0.005 0.0103 0.0238
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0306 0.0971
Echinococcus multilocularis serotonin receptor 0.0016 0.0001 0.0001
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0022 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0239
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0043 0.0083 0.0083
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0193 0.0722
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni intermediate filament proteins 0.0119 0.0312 0.072
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0003 0.0007
Onchocerca volvulus 0.0017 0.0003 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.0474 0.1377 0.1377
Loa Loa (eye worm) abnormal epIthelia family member 0.005 0.0103 0.0386
Echinococcus multilocularis regulator of G protein signaling 3 0.0043 0.0083 0.0083
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0073 0.1124
Schistosoma mansoni lamin 0.0119 0.0312 0.072
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0008 0.0008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.011 0.041
Schistosoma mansoni opsin-like receptor 0.0016 0.0001 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0099 0.0251 0.0579
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0043 0.0083 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0026 0.0032 0.0586
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0008 0.003
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0062 0.014 0.4035
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0073 0.0208
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0008 0.003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0027 0.0034 0.0954
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0008 0.003
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0073 0.0073
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0001 0.0001
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.005 0.0103 0.0386
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0264 0.0745 0.2783
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.007 0.0197
Schistosoma mansoni lipoxygenase 0.0064 0.0146 0.0336
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0062 0.0139 0.4514
Brugia malayi hypothetical protein 0.0026 0.0032 0.0121
Onchocerca volvulus 0.0017 0.0003 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0003 0.0008
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0043 0.0083 0.0308
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0032 0.0073
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0019 0.0011 0.0037
Leishmania major hypothetical protein, conserved 0.0025 0.0027 0.0307
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Echinococcus granulosus RUN 0.0023 0.0022 0.0022
Onchocerca volvulus 0.0018 0.0008 0.0026
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0008 0.0018
Schistosoma mansoni rab6-interacting 0.0023 0.0022 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0013 0.0013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.016 0.5191
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0239
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0043 0.0083 0.0308
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0019 0.0011 0.0022
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0089 0.0089
Schistosoma mansoni amine GPCR 0.0016 0.0001 0.0002
Echinococcus granulosus leukotriene A 4 hydrolase 0.0383 0.1105 0.1105
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0062 0.0139 0.5
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0032 0.0973
Loa Loa (eye worm) hypothetical protein 0.0117 0.0306 0.1141
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0083 0.019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0001 0.0001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0067 0.2125
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0073 0.0073
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0032 0.0394
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0013 0.0029
Brugia malayi G protein-coupled receptor 0.0016 0.0001 0.0003
Echinococcus multilocularis nAChR subunit 0.0018 0.0008 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Echinococcus granulosus Regulator of G protein signaling 20 0.0043 0.0083 0.0083
Schistosoma mansoni neuropeptide receptor 0.0016 0.0001 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0193 0.6112
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.005 0.0188
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0308
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Toxoplasma gondii microneme protein, putative 0.0017 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0308
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.016 0.5191
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0121
Onchocerca volvulus 0.0026 0.0032 0.0106
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0008 0.003
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0001 0.0001
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0032 0.0121
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0308
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0001 0.0002
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0306 0.0705
Echinococcus granulosus collagen alpha 1VII chain 0.0062 0.014 0.014
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0008 0.003
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0306 0.5246
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0306 1
Echinococcus granulosus tissue type plasminogen activator 0.0026 0.0031 0.0031
Mycobacterium ulcerans hypothetical protein 0.0021 0.0017 0.0117
Echinococcus multilocularis tissue type plasminogen activator 0.0026 0.0031 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0013 0.0013
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0089 0.0334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0386
Brugia malayi Fli-1 protein 0.0214 0.0596 0.2228
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0016 0.0001 0.0002
Brugia malayi Serotonin receptor 0.0016 0.0001 0.0003
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0079 0.0192 0.0192
Onchocerca volvulus 0.002 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni nAChR subunit 0.0018 0.0008 0.0018
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0306 0.0306
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0001 0.0001
Mycobacterium ulcerans sulfatase 0.0019 0.0011 0.0022
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.0392 0.0392
Mycobacterium ulcerans hydrolase 0.0019 0.0011 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0038
Loa Loa (eye worm) hypothetical protein 0.008 0.0193 0.0722
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0001 0.0003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0008 0.003
Schistosoma mansoni blooms syndrome DNA helicase 0.0029 0.004 0.0093
Brugia malayi hypothetical protein 0.0023 0.0022 0.0084
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0062 0.014 0.241
Schistosoma mansoni hypothetical protein 0.0062 0.014 0.0324
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.001 0.0038
Brugia malayi Dopamine receptor 0.0016 0.0001 0.0003
Mycobacterium ulcerans arylsulfatase AtsD 0.0019 0.0011 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0131 0.0346 0.1134
Schistosoma mansoni hypothetical protein 0.0023 0.0022 0.0052
Brugia malayi hypothetical protein 0.0043 0.0083 0.0308
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0062 0.0139 0.448
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0047
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0042 0.0081 0.3449
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Echinococcus granulosus hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi phosphofructokinase 0.0117 0.0306 0.1141
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0032 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.001 0.001
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0058 0.1831
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0008 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0001 0.0001
Schistosoma mansoni DNA helicase recq5 0.0032 0.005 0.0116
Loa Loa (eye worm) hypothetical protein 0.0516 0.1501 0.5608
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.007 0.0261
Echinococcus granulosus FTZ F1 alpha 0.002 0.0013 0.0013
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0001 0.0001
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Brugia malayi Zona pellucida-like domain containing protein 0.0062 0.014 0.0524
Brugia malayi von Willebrand factor type A domain containing protein 0.0062 0.014 0.0524
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0049 0.0804
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0001 0.0002
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0032 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0008 0.0008
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0017 0.0003 0.0008
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0474 0.1377 0.3175
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0062 0.014 0.0524
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0032 0.0752
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0047
Onchocerca volvulus 0.0062 0.014 0.046
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0001 0.0001
Brugia malayi G-protein coupled receptor 0.0016 0.0001 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0001 0.0002
Schistosoma mansoni opsin-like receptor 0.0016 0.0001 0.0002
Brugia malayi PXA domain containing protein 0.0043 0.0083 0.0308
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0038
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0062 0.014 0.4035
Echinococcus multilocularis beta adrenergic receptor kinase 0.0043 0.0083 0.0083
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0297
Echinococcus granulosus serotonin receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0083 0.019
Onchocerca volvulus 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0386
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0084
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0062 0.014 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0013 0.0047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0013 0.0013
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0013 0.0041
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0002
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0193 0.5567
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.0033 0.0054 0.0124
Toxoplasma gondii exonuclease III APE 0.0062 0.0139 0.2377
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0047
Schistosoma mansoni ap endonuclease 0.0062 0.0139 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Schistosoma mansoni nAChR subunit 0.0018 0.0008 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0306 0.0971
Onchocerca volvulus 0.0026 0.0032 0.0106
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0001 0.0003
Onchocerca volvulus 0.0016 0.0001 0.0002
Echinococcus granulosus metabotropic glutamate receptor 5 0.0117 0.0304 0.0304
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0008 0.003
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0002
Echinococcus granulosus cpg binding protein 0.0035 0.0059 0.0059
Schistosoma mansoni cpg binding protein 0.0035 0.0059 0.0137
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0073 0.0073
Entamoeba histolytica recQ family helicase, putative 0.0035 0.0058 0.1881
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0239
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Schistosoma mansoni amine GPCR 0.0016 0.0001 0.0002
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0008 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0013 0.0013
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0032 0.0394
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.016 0.016
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0086 0.0212 0.0791
Loa Loa (eye worm) RGS-3 protein 0.0043 0.0083 0.0308
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0008 0.0008
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0001 0.0002
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0013 0.0029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0308
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0013 0.0029
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0099 0.0251 0.0579
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0049 0.0804
Plasmodium vivax hypothetical protein, conserved 0.0062 0.014 0.4035
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0001 0.0001
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0026 0.0032 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0064 0.0146 0.0544
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0064 0.0146 0.0146
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0008 0.0018
Schistosoma mansoni biogenic amine receptor 0.0016 0.0001 0.0002
Brugia malayi hypothetical protein 0.0255 0.0719 0.2686
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0016 0.0001 0.0002
Onchocerca volvulus 0.0062 0.014 0.046
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Entamoeba histolytica hypothetical protein, conserved 0.0062 0.014 0.4575
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0043 0.0083 0.019
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0001 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Echinococcus multilocularis Regulator of G protein signaling 20 0.0043 0.0083 0.0083
Leishmania major hypothetical protein, conserved 0.0026 0.0031 0.0361
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0058 0.0127 0.0127
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0049 0.1547
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0064 0.0146 0.0146
Brugia malayi Kringle domain containing protein 0.0026 0.0031 0.0114
Schistosoma mansoni opsin-like receptor 0.0016 0.0001 0.0002
Brugia malayi exodeoxyribonuclease III family protein 0.0062 0.0139 0.0517
Giardia lamblia Sgs1 DNA helicase, putative 0.0032 0.005 0.3123
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0001 0.0001
Schistosoma mansoni ets-related 0.0214 0.0596 0.1375
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0193 1
Echinococcus multilocularis pikachurin 0.005 0.0103 0.0103
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.001 0.001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0054 0.0201
Schistosoma mansoni thyroid hormone receptor 0.0166 0.045 0.1039
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Echinococcus multilocularis dna polymerase kappa 0.0019 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0001 0.0001
Echinococcus multilocularis geminin 0.0196 0.0543 0.0543
Brugia malayi AKH receptor 0.0016 0.0001 0.0003
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0001 0.0001
Brugia malayi nuclear receptor NHR-88 0.002 0.0013 0.0047
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0032 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0083 0.019
Onchocerca volvulus 0.0017 0.0003 0.0011
Brugia malayi regulator of G-protein signaling rgs-7 0.0043 0.0083 0.0308
Loa Loa (eye worm) hypothetical protein 0.0062 0.014 0.0524
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0008 0.003
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0032 0.005 0.1631
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0001 0.0001
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0001 0.0001
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.016 0.5074
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0206 0.0573 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0032 0.0973
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0013 0.0013
Toxoplasma gondii PAN domain-containing protein 0.0017 0.0003 0.0008
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0001 0.0001
Schistosoma mansoni slit 0.005 0.0103 0.0238
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0008 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0139 0.0422
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0386
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Echinococcus granulosus intermediate filament protein 0.0119 0.0312 0.0312
Brugia malayi RE15519p 0.0016 0.0001 0.0003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0001 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.003
Echinococcus multilocularis slit 2 protein 0.005 0.0103 0.0103
Treponema pallidum exodeoxyribonuclease (exoA) 0.0062 0.0139 0.0228
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0001 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0013 0.0047
Brugia malayi hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0047
Treponema pallidum hypothetical protein 0.0062 0.014 0.0231
Loa Loa (eye worm) hypothetical protein 0.0117 0.0304 0.1136
Echinococcus granulosus orexin receptor type 2 0.0016 0.0001 0.0001
Brugia malayi Dopamine receptor protein 1 0.0516 0.1501 0.5608
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0001 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0013 0.0013
Schistosoma mansoni biogenic amine receptor 0.0016 0.0001 0.0002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0058 0.0127 0.0127
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0001 0.0003
Echinococcus granulosus axis inhibition protein axin 0.0043 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0013 0.0047
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0008 0.003
Toxoplasma gondii hypothetical protein 0.0017 0.0003 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0206 0.0573 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0003
Toxoplasma gondii PAN/Apple domain-containing protein 0.0017 0.0003 0.0008
Echinococcus multilocularis serotonin receptor 0.0016 0.0001 0.0001
Echinococcus granulosus regulator of G protein signaling 3 0.0043 0.0083 0.0083
Echinococcus multilocularis regulator of G protein signaling 0.0043 0.0083 0.0083
Brugia malayi laminin-like protein K08C7.3 precursor 0.005 0.0103 0.0386
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0027 0.0585
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.003 0.0043 0.0099
Onchocerca volvulus 0.0018 0.0008 0.0026
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0001 0.0001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0008 0.003
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0043 0.0083 0.019
Trypanosoma brucei aminopeptidase, putative 0.0026 0.0032 0.0752
Mycobacterium ulcerans endonuclease IV 0.008 0.0193 0.3252
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0043 0.0083 0.0308
Schistosoma mansoni nAChR subunit 0.0018 0.0008 0.0018
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0001 0.0003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.005 0.083
Schistosoma mansoni histamine h1 receptor 0.0016 0.0001 0.0002
Brugia malayi PAN domain containing protein 0.0017 0.0003 0.0013
Echinococcus granulosus bloom syndrome protein 0.0045 0.0089 0.0089
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0008 0.0008
Brugia malayi Serotonin receptor 0.0016 0.0001 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0031 0.0911

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 94 nM Ability of the compound to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue ChEMBL. 9171869
EC50 (functional) = 94 nM Ability of the compound to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue ChEMBL. 9171869
IA (functional) = 71 % Intrinsic activity of the compound is the magnitude of response for stimulation of Dopamine receptor D1 like expressed as percent relative to the dopamine ChEMBL. 9171869
IA (functional) = 71 % Intrinsic activity of the compound is the magnitude of response for stimulation of Dopamine receptor D1 like expressed as percent relative to the dopamine ChEMBL. 9171869
Ki (binding) = 150 nM In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand ChEMBL. 9171869
Ki (binding) = 150 nM In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand ChEMBL. 9171869
Ki (binding) = 3110 nM In vitro binding affinity against Dopamine receptor D2 like from rat caudate membrane using [3H]-spiperone as radioligand ChEMBL. 9171869
Ki (binding) = 3110 nM In vitro binding affinity against Dopamine receptor D2 like from rat caudate membrane using [3H]-spiperone as radioligand ChEMBL. 9171869
Ki (binding) > 20000 nM In vitro binding affinity against adrenergic Alpha-2 adrenergic receptor from rat cortical membrane using [3H]-rauwolscine as radioligand ChEMBL. 9171869
Ki (binding) > 20000 nM In vitro binding affinity against adrenergic Alpha-2 adrenergic receptor from rat cortical membrane using [3H]-rauwolscine as radioligand ChEMBL. 9171869
Selectivity ratio (binding) = 20 Binding selectivity against D2/D1 receptor. ChEMBL. 9171869
Selectivity ratio (binding) > 130 Binding selectivity against alpha-2/D1 receptor. ChEMBL. 9171869

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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