Detailed information for compound 984077

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.527 | Formula: C27H29F3N2O
  • H donors: 1 H acceptors: 1 LogP: 7.26 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(nc2c1C(CCC2)Nc1ccccc1C(F)(F)F)c1c(CC)cccc1CC
  • InChi: 1S/C27H29F3N2O/c1-4-17-10-8-11-18(5-2)25(17)23-16-24(33-3)26-21(14-9-15-22(26)32-23)31-20-13-7-6-12-19(20)27(28,29)30/h6-8,10-13,16,21,31H,4-5,9,14-15H2,1-3H3
  • InChiKey: AESSRSHXFGCUGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens complement component 5a receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis G-protein coupled receptor, putative complement component 5a receptor 1 350 aa 293 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0103 0.0076 0.1871
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0019 0.002
Schistosoma mansoni amine oxidase 0.0103 0.0076 0.0085
Echinococcus granulosus integrin alpha 3 0.1228 0.1265 0.1442
Entamoeba histolytica hypothetical protein, conserved 0.0101 0.0074 0.1032
Plasmodium vivax plasmepsin V, putative 0.0398 0.0387 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0273 0.0255 0.0345
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.01 0.0072 0.1997
Echinococcus granulosus disintegrin and metalloproteinase 0.0096 0.0068 0.0077
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0062 0.0033 0.0828
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0103 0.0076 0.1871
Mycobacterium leprae Probable polyketide synthase Pks1 0.0089 0.0061 0.1256
Echinococcus multilocularis integrin alpha ps 0.0403 0.0393 0.0531
Onchocerca volvulus 0.0551 0.0549 1
Schistosoma mansoni hypothetical protein 0.005 0.0019 0.0021
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0364 0.0352 0.04
Brugia malayi AMP-binding enzyme family protein 0.0081 0.0052 0.0052
Echinococcus granulosus protein will die slowly 0.0071 0.0042 0.0047
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0285 0.0268 0.0268
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0019 0.002
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0084 0.0056 0.5
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0551 0.0549 0.0549
Schistosoma mansoni hypothetical protein 0.0403 0.0393 0.0447
Mycobacterium ulcerans Type I modular polyketide synthase 0.0084 0.0055 0.0949
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0143 0.0118 0.0118
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0064 0.0034 0.0038
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0686 0.0692 0.0788
Brugia malayi hypothetical protein 0.0303 0.0287 0.0287
Echinococcus granulosus adam 0.0513 0.0509 0.058
Leishmania major UDP-galactopyranose mutase 0.0103 0.0076 0.1061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2011 0.2093 0.3916
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Echinococcus granulosus Furin 1 0.2011 0.2093 0.2386
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.01 0.0072 0.0081
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0101 0.0074 0.1032
Mycobacterium ulcerans Type I modular polyketide synthase 0.0084 0.0055 0.0949
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0243 0.0224 0.0224
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0002 0.0001
Giardia lamblia High cysteine protein 0.021 0.0189 0.0552
Loa Loa (eye worm) endoprotease bli-4 0.8326 0.8768 0.8768
Loa Loa (eye worm) hypothetical protein 0.005 0.0019 0.0019
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.01 0.0072 0.0097
Echinococcus granulosus protein arginine N methyltransferase 8 0.006 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0101 0.0074 0.0099
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0364 0.0352 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.014 0.0114 0.0129
Loa Loa (eye worm) TK/ALK protein kinase 0.0093 0.0065 0.0065
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.1263 0.1302 0.1302
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0084 0.0056 0.0966
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0034 0.0003 0.0002
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0686 0.0692 1
Schistosoma mansoni serine/threonine protein kinase 0.0509 0.0505 0.0575
Schistosoma mansoni chromatin regulatory protein sir2 0.0101 0.0074 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0146 0.0121 0.0121
Toxoplasma gondii F5/8 type C domain-containing protein 0.005 0.0019 0.0474
Loa Loa (eye worm) hypothetical protein 0.021 0.0189 0.0189
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0232 0.0212 0.024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2011 0.2093 0.3916
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0059 0.0029 0.0032
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1302 0.1343 0.1531
Mycobacterium ulcerans polyketide synthase 0.0089 0.0061 0.1123
Schistosoma mansoni integrin beta subunit 0.5549 0.5832 0.6651
Loa Loa (eye worm) hypothetical protein 0.0094 0.0066 0.0066
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0232 0.0212 0.0286
Echinococcus granulosus protein kinase c epsilon type 0.0106 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0059 0.0029 0.0029
Brugia malayi hypothetical protein 0.0091 0.0063 0.0063
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0004 0.0004
Entamoeba histolytica SWIRM domain protein 0.0043 0.0012 0.0138
Schistosoma mansoni septate junction protein 0.0058 0.0028 0.0031
Brugia malayi Furin-like cysteine rich region family protein 0.0467 0.0461 0.0461
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0101 0.0074 0.0083
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Brugia malayi Disintegrin family protein 0.0096 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0364 0.0352 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.0076 0.1061
Giardia lamblia Furin precursor putative serine protease 0.1647 0.1708 0.5296
Onchocerca volvulus 0.0052 0.0022 0.0323
Schistosoma mansoni discoidin domain receptor 0.005 0.0019 0.0021
Echinococcus multilocularis fibrillin 1 0.0212 0.0191 0.0257
Loa Loa (eye worm) hypothetical protein 0.0103 0.0076 0.0076
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.0019 0.0024
Schistosoma mansoni hypothetical protein 0.0091 0.0063 0.007
Brugia malayi Carm1-pending protein 0.0034 0.0003 0.0003
Echinococcus multilocularis raf serine:threonine protein kinase 0.0509 0.0505 0.0684
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.0004 0.0043
Echinococcus granulosus protein arginine N methyltransferase 7 0.0034 0.0003 0.0002
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0686 0.0692 1
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Loa Loa (eye worm) transcriptional regulator 0.0101 0.0074 0.0074
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0364 0.0352 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5083 0.534 1
Mycobacterium ulcerans dehydrogenase 0.0103 0.0076 0.1578
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0059 0.0029 0.0038
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.006 0.003 0.0052
Loa Loa (eye worm) glutamate receptor 1 0.0032 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.021 0.0189 0.0189
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0101 0.0074 0.1818
Trichomonas vaginalis conserved hypothetical protein 0.0364 0.0352 0.0654
Echinococcus multilocularis protein will die slowly 0.0071 0.0042 0.0056
Schistosoma mansoni protein kinase 0.014 0.0114 0.0129
Onchocerca volvulus Putative cubilin 0.0038 0.0007 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Brugia malayi metalloprotease 0.0064 0.0034 0.0034
Brugia malayi endoprotease bli-4 precursor 0.8326 0.8768 0.8768
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0074 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0019 0.002
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0101 0.0074 0.0099
Toxoplasma gondii F5/8 type C domain-containing protein 0.005 0.0019 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0012 0.0018
Toxoplasma gondii subtilisin SUB4 0.0364 0.0352 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0103 0.0076 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0083 0.0054 0.0924
Trichomonas vaginalis conserved hypothetical protein 0.0364 0.0352 0.0654
Brugia malayi hypothetical protein 0.0035 0.0004 0.0004
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0364 0.0352 1
Leishmania major arginine N-methyltransferase-like protein 0.006 0.003 0.0403
Giardia lamblia Tenascin-like 0.021 0.0189 0.0552
Brugia malayi Protein kinase domain containing protein 0.0093 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.3243 0.3395 0.3395
Plasmodium falciparum subtilisin-like protease 3 0.0364 0.0352 0.9068
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0103 0.0076 0.1578
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0686 0.0692 0.1292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2011 0.2093 0.3916
Schistosoma mansoni SWI/SNF complex-related 0.0043 0.0012 0.0013
Toxoplasma gondii subtilisin SUB12 0.0364 0.0352 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2011 0.2093 0.3916
Toxoplasma gondii aspartyl protease 0.0035 0.0004 0.0043
Mycobacterium leprae Possible secreted protease 0.0364 0.0352 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0101 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0505 0.05 0.05
Schistosoma mansoni glutamate receptor NMDA 0.0273 0.0255 0.029
Onchocerca volvulus 0.021 0.0189 0.3394
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Brugia malayi hypothetical protein 0.0035 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Toxoplasma gondii subtilisin SUB5 0.0364 0.0352 1
Brugia malayi ADAM-TS Spacer 1 family protein 0.0136 0.011 0.011
Plasmodium falciparum subtilisin-like protease 2 0.0364 0.0352 0.9068
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0101 0.0074 0.1032
Echinococcus multilocularis integrin alpha ps 0.0841 0.0855 0.1159
Mycobacterium ulcerans polyketide synthase Pks13 0.0127 0.0101 0.2334
Schistosoma mansoni chromatin regulatory protein sir2 0.0101 0.0074 0.0083
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0089 0.0061 0.1641
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5083 0.534 1
Schistosoma mansoni hypothetical protein 0.0059 0.0029 0.0032
Giardia lamblia Hypothetical protein 0.0686 0.0692 0.2123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.0224 0.0254
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0054 0.0024 0.015
Schistosoma mansoni discoidin domain receptor 0.005 0.0019 0.0021
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0067 0.0037 0.0546
Schistosoma mansoni tyrosine kinase 0.0467 0.0461 0.0525
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0103 0.0076 0.1705
Onchocerca volvulus 0.005 0.0019 0.0276
Toxoplasma gondii subtilisin SUB8 0.0364 0.0352 1
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.005 0.0019 0.0021
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0084 0.0055 0.0949
Giardia lamblia Neurogenic locus Notch protein precursor 0.021 0.0189 0.0552
Loa Loa (eye worm) hypothetical protein 0.0136 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0079 0.005 0.005
Brugia malayi Glutamate receptor 2 precursor 0.0032 0.0001 0.0001
Leishmania major sir2-family protein-like protein 0.0101 0.0074 0.1032
Schistosoma mansoni atypical protein kinase C 0.0033 0.0002 0.0001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0074 0.0133
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0019 0.0024
Schistosoma mansoni protein arginine n-methyltransferase 0.0034 0.0003 0.0002
Echinococcus granulosus adam 17 protease 0.0096 0.0068 0.0077
Onchocerca volvulus 0.0134 0.0109 0.1916
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1487 0.1538 0.1538
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0076 0.1871
Loa Loa (eye worm) apoptosis regulator protein 0.0059 0.0029 0.0029
Toxoplasma gondii subtilisin SUB6 0.0364 0.0352 1
Echinococcus multilocularis discoidin domain containing receptor 2 0.005 0.0019 0.0025
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0043 0.0012 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0103 0.0076 0.207
Brugia malayi EGF-like domain containing protein 0.021 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.1457 0.1507 0.1507
Loa Loa (eye worm) angiogenesis inhibito 0.0064 0.0034 0.0034
Toxoplasma gondii subtilisin SUB9 0.0364 0.0352 1
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Echinococcus multilocularis Furin 1 0.2011 0.2093 0.2838
Loa Loa (eye worm) hypothetical protein 0.0096 0.0068 0.0068
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0686 0.0692 0.0937
Echinococcus multilocularis fibrillin 2 0.021 0.0189 0.0255
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0122 0.0096 0.0096
Echinococcus granulosus membrane bound transcription factor site 1 0.0364 0.0352 0.04
Plasmodium vivax NAD-dependent deacetylase, putative 0.0101 0.0074 0.1818
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Schistosoma mansoni protein arginine N-methyltransferase 1 0.006 0.003 0.0034
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0686 0.0692 0.1292
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0393 0.0383 0.551
Onchocerca volvulus 0.0151 0.0126 0.2245
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1647 0.1708 0.3195
Brugia malayi ADAMTS-like protease 0.0136 0.011 0.011
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0101 0.0074 0.0099
Brugia malayi Integrin alpha pat-2 precursor 0.1666 0.1728 0.1728
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0004 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0074 0.0133
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Echinococcus granulosus discoidin domain containing receptor 2 0.005 0.0019 0.0021
Trypanosoma cruzi subtilisin peptidase 0.0364 0.0352 0.506
Echinococcus granulosus protein arginine methyltransferase 0.006 0.003 0.0034
Mycobacterium ulcerans NAD-dependent deacetylase 0.0101 0.0074 0.1516
Mycobacterium ulcerans Sir2-like regulatory protein 0.0101 0.0074 0.1516
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0068 0.0039 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2011 0.2093 0.3916
Echinococcus multilocularis integrin alpha ps 0.0908 0.0926 0.1255
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0004 0.0003
Loa Loa (eye worm) metalloprotease 0.0064 0.0034 0.0034
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0393 0.0383 0.551
Echinococcus granulosus lysine specific histone demethylase 1A 0.0508 0.0503 0.0573
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0004 0.0004
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0508 0.0503 0.0682
Echinococcus multilocularis MAM 0.0091 0.0063 0.0084
Trypanosoma brucei SIR2-like protein 4, putative 0.0101 0.0074 0.1032
Echinococcus granulosus chromatin regulatory protein sir2 0.0686 0.0692 0.0788
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.0004
Loa Loa (eye worm) integrin alpha pat-2 0.2359 0.246 0.246
Schistosoma mansoni chromatin regulatory protein sir2 0.0686 0.0692 0.0788
Toxoplasma gondii histone deacetylase SIR2-like 0.0101 0.0074 0.2039
Giardia lamblia Tenascin-X 0.021 0.0189 0.0552
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0364 0.0352 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.01 0.0072 0.1011
Onchocerca volvulus 0.0071 0.0042 0.0694
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2011 0.2093 0.2386
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0081 0.0052 0.0052
Brugia malayi amine oxidase, flavin-containing family protein 0.0146 0.0121 0.0121
Loa Loa (eye worm) subtilase 0.0364 0.0352 0.0352
Mycobacterium ulcerans oxidoreductase 0.0103 0.0076 0.1578
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0393 0.0383 0.551
Schistosoma mansoni hypothetical protein 0.1647 0.1708 0.1947
Schistosoma mansoni site-1 peptidase (S08 family) 0.0364 0.0352 0.04
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0074 0.0133
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0002 0.0001
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0004 0.0004
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0103 0.0076 0.1871
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0074 0.0133
Giardia lamblia Sirtuin type 2 0.0101 0.0074 0.0192
Plasmodium falciparum LCCL domain-containing protein 0.005 0.0019 0.0392
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.01 0.0072 0.0081
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.01 0.0072 0.1011
Toxoplasma gondii PA14 domain-containing protein 0.005 0.0019 0.0474
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1647 0.1708 0.3195
Echinococcus granulosus integrin beta 2 0.7006 0.7372 0.8408
Schistosoma mansoni protein kinase 0.014 0.0114 0.0129
Brugia malayi Glutamate receptor 1 precursor 0.0032 0.0001 0.0001
Onchocerca volvulus Fatty acid synthase homolog 0.0156 0.0132 0.2349
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0364 0.0352 1
Echinococcus granulosus discoidin domain receptor 0.005 0.0019 0.0021
Echinococcus granulosus fibrillin 2 0.021 0.0189 0.0214
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.005 0.0019 0.044
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0686 0.0692 1
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0084 0.0056 0.1101
Brugia malayi Calcium binding EGF domain containing protein 0.0038 0.0007 0.0007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0067 0.0037 0.0402
Echinococcus multilocularis chromatin regulatory protein sir2 0.0686 0.0692 0.0937
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0364 0.0352 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0072 0.0043 0.0723
Trichomonas vaginalis hypothetical protein 0.021 0.0189 0.0349
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0364 0.0352 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0739 0.0748 0.0852
Trichomonas vaginalis beta-hexosaminidase B, putative 0.005 0.0019 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0059 0.0029 0.0032
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0081 0.0052 0.1398
Echinococcus granulosus discoidin domain containing receptor 2 0.005 0.0019 0.0021
Entamoeba histolytica SWIRM domain protein 0.0043 0.0012 0.0138
Schistosoma mansoni site-1 peptidase (S08 family) 0.0364 0.0352 0.04
Schistosoma mansoni chromatin regulatory protein sir2 0.0101 0.0074 0.0083
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.005 0.0019 0.0025
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0019 0.002
Echinococcus multilocularis epidermal growth factor receptor 0.0467 0.0461 0.0624
Schistosoma mansoni hypothetical protein 0.0059 0.0029 0.0032
Echinococcus granulosus integrin alpha ps 0.0908 0.0926 0.1056
Schistosoma mansoni hypothetical protein 0.0034 0.0003 0.0002
Echinococcus multilocularis protein arginine methyltransferase 0.006 0.003 0.004
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Brugia malayi hypothetical protein 0.1457 0.1507 0.1507
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Echinococcus multilocularis integrin beta 2 0.7006 0.7372 1
Echinococcus granulosus furin 0.8326 0.8768 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0237 0.0217 0.0246
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0101 0.0074 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Toxoplasma gondii aspartyl protease ASP5 0.0362 0.035 0.9953
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0122 0.0096 0.0096
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.01 0.0072 0.8369
Echinococcus multilocularis nmda type glutamate receptor 0.0115 0.0089 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0303 0.0287 0.0327
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0364 0.0352 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Entamoeba histolytica hypothetical protein 0.0094 0.0066 0.0924
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0034 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.021 0.0189 0.0189
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0101 0.0074 0.1032
Loa Loa (eye worm) hypothetical protein 0.0067 0.0038 0.0038
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0364 0.0352 0.506
Loa Loa (eye worm) fatty acid synthase 0.0086 0.0057 0.0057
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0739 0.0748 0.1014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Toxoplasma gondii subtilisin SUB7 0.0364 0.0352 1
Echinococcus multilocularis protein jagged 2 0.021 0.0189 0.0255
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.006 0.003 0.0797
Giardia lamblia Neurogenic locus notch-like protein 0.021 0.0189 0.0552
Echinococcus granulosus raf serine:threonine protein kinase 0.0509 0.0505 0.0575
Brugia malayi SWIRM domain containing protein 0.0551 0.0549 0.0549
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0004 0.0004
Schistosoma mansoni amine oxidase 0.0103 0.0076 0.0085
Loa Loa (eye worm) acyl carrier protein 0.004 0.0009 0.0009
Toxoplasma gondii subtilisin SUB11 0.0364 0.0352 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0103 0.0076 0.1578
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Leishmania major subtilisin-like serine peptidase 0.0364 0.0352 0.506
Echinococcus multilocularis disintegrin and metalloproteinase 0.0096 0.0068 0.0091
Giardia lamblia hypothetical protein 0.021 0.0189 0.0552
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0004 0.0043
Schistosoma mansoni hypothetical protein 0.0071 0.0042 0.0047
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0083 0.0054 0.1454
Onchocerca volvulus 0.0081 0.0052 0.0887
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.01 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.021 0.0189 0.0189
Giardia lamblia Tenascin-37 0.021 0.0189 0.0552
Trichomonas vaginalis WD repeat domain, putative 0.0071 0.0042 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0364 0.0352 0.0654
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0074 0.0133
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0067 0.0037 0.0402
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.006 0.003 0.0052
Brugia malayi transcriptional regulator, Sir2 family protein 0.0686 0.0692 0.0692
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.01 0.0072 0.178
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0103 0.0076 0.1578
Brugia malayi transcriptional regulator, Sir2 family protein 0.0101 0.0074 0.0074
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5083 0.534 0.7243
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0034 0.0003 0.0003
Toxoplasma gondii subtilisin SUB10 0.0364 0.0352 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0161 0.0137 0.0137
Plasmodium falciparum LCCL domain-containing protein 0.005 0.0019 0.0392
Toxoplasma gondii F5/8 type C domain-containing protein 0.005 0.0019 0.0474
Brugia malayi neuroendocrine convertase 1 precursor 0.5254 0.552 0.552
Giardia lamblia High cysteine protein 0.021 0.0189 0.0552
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0084 0.0056 0.1493
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0103 0.0076 0.1871
Schistosoma mansoni btb and poz domain-containing protein 0.005 0.0019 0.0021
Loa Loa (eye worm) integrin beta-2 0.9492 1 1
Toxoplasma gondii subtilisin SUB1 0.0364 0.0352 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0089 0.0061 0.1123
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Loa Loa (eye worm) proprotein convertase 2 0.2011 0.2093 0.2093
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0243 0.0224 0.0302
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0074 0.0133
Schistosoma mansoni protein kinase 0.014 0.0114 0.0129
Toxoplasma gondii type I fatty acid synthase, putative 0.0062 0.0032 0.0843
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0115 0.0089 0.0119
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.01 0.0072 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.014 0.0114 0.0154
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Plasmodium falciparum protein arginine N-methyltransferase 1 0.006 0.003 0.0686
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Plasmodium vivax LCCL domain-containing protein 0.005 0.0019 0.0392
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Echinococcus multilocularis serine:threonine protein kinase N2 0.0081 0.0053 0.007
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Echinococcus multilocularis integrin alpha 3 0.1228 0.1265 0.1715
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Mycobacterium tuberculosis Probable thioesterase TesA 0.0072 0.0043 0.1131
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0094 0.0066 0.0924
Brugia malayi Subtilase family protein 0.0364 0.0352 0.0352
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2011 0.2093 0.3916
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0106 0.0079 0.0079
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0004 0.0003
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.01 0.0072 0.178
Loa Loa (eye worm) hypothetical protein 0.0364 0.0352 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Onchocerca volvulus 0.0091 0.0063 0.1073
Schistosoma mansoni chromatin regulatory protein sir2 0.0686 0.0692 0.0788
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0127 0.0101 0.2782
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0013 0.0301
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Loa Loa (eye worm) Carm1-pending protein 0.0034 0.0003 0.0003
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0019 0.0024
Echinococcus granulosus fibrillin 1 0.0212 0.0191 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8326 0.8768 1
Loa Loa (eye worm) sirtuin 4 0.0101 0.0074 0.0074
Brugia malayi Protein arginine N-methyltransferase 0.0034 0.0003 0.0003
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0043 0.0012 0.0013
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.01 0.0072 0.1011
Leishmania major silent information regulator 2, putative 0.0686 0.0692 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0042 0.0042
Echinococcus multilocularis 0.0103 0.0076 0.0102
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0056 0.0026 0.0677
Loa Loa (eye worm) hypothetical protein 0.0103 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0007 0.0007
Echinococcus granulosus discoidin domain containing receptor 2 0.005 0.0019 0.0021
Schistosoma mansoni apoptosis regulator bax 0.0059 0.0029 0.0032
Plasmodium falciparum subtilisin-like protease 1 0.0364 0.0352 0.9068
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0068 0.0039 0.0997
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0059 0.0029 0.0029
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0686 0.0692 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0101 0.0074 0.0083
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0101 0.0074 0.2011
Loa Loa (eye worm) hypothetical protein 0.005 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0074 0.1818
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.006 0.003 0.0686
Loa Loa (eye worm) transcriptional regulator 0.0686 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0091 0.0063 0.0063
Schistosoma mansoni ATP-binding cassette transporter 0.0034 0.0002 0.0002
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0089 0.0061 0.1123
Loa Loa (eye worm) reprolysin 0.0232 0.0212 0.0212
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0101 0.0074 0.1032
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0084 0.0056 0.149
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0019 0.0024
Plasmodium falciparum protoporphyrinogen oxidase 0.0103 0.0076 0.1871
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0232 0.0212 0.024
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0094 0.0066 0.0924
Brugia malayi Pepsin A precursor 0.0035 0.0004 0.0004
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0094 0.0066 0.0924
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0096 0.0068 0.0077
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0364 0.0352 0.0476
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0508 0.0503 0.0573
Toxoplasma gondii histone lysine-specific demethylase 0.0103 0.0076 0.2097
Loa Loa (eye worm) hypothetical protein 0.8326 0.8768 0.8768
Brugia malayi celfurPC protein 0.6679 0.7027 0.7027
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0364 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Mycobacterium ulcerans thioesterase TesA 0.0072 0.0043 0.0581
Echinococcus multilocularis discoidin domain receptor 0.005 0.0019 0.0025
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0084 0.0055 0.1477
Onchocerca volvulus 0.0091 0.0063 0.1073
Trichomonas vaginalis alpha-L-fucosidase, putative 0.005 0.0019 0.0031
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.1647 0.1708 0.3195
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0101 0.0074 0.0083
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0084 0.0055 0.1477
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0004 0.0043
Toxoplasma gondii SWIRM domain-containing protein 0.0043 0.0012 0.0273
Echinococcus granulosus glutamate receptor 2 0.0049 0.0019 0.002
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0686 0.0692 1
Echinococcus multilocularis discoidin domain containing receptor 2 0.005 0.0019 0.0025
Brugia malayi EGF-like domain containing protein 0.021 0.0189 0.0189
Brugia malayi EGF-like domain containing protein 0.021 0.0189 0.0189
Onchocerca volvulus 0.0364 0.0352 0.6378
Trypanosoma brucei subtilisin peptidase 0.0364 0.0352 0.506
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Loa Loa (eye worm) hypothetical protein 0.0064 0.0034 0.0034
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0084 0.0056 0.01
Brugia malayi Raf kinase 0.0485 0.048 0.048
Mycobacterium tuberculosis Possible oxidoreductase 0.0103 0.0076 0.207
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0091 0.0063 0.007
Mycobacterium ulcerans Type I modular polyketide synthase 0.0084 0.0055 0.0949
Loa Loa (eye worm) hypothetical protein 0.0508 0.0503 0.0503
Echinococcus granulosus methyltransferase protein 5 0.0034 0.0003 0.0002
Plasmodium vivax LCCL domain-containing protein 0.005 0.0019 0.0392
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0364 0.0352 1
Echinococcus granulosus integrin alpha ps 0.0403 0.0393 0.0447
Loa Loa (eye worm) hypothetical protein 0.047 0.0464 0.0464
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0044 0.0593
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0364 0.0352 0.04
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Mycobacterium ulcerans thioesterase 0.0072 0.0043 0.0581
Toxoplasma gondii histone deacetylase SIR2 0.0101 0.0074 0.2039
Echinococcus granulosus Protein kinase C brain isozyme 0.0035 0.0004 0.0003
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0089 0.0061 0.1641
Mycobacterium leprae Polyketide synthase Pks13 0.0127 0.0101 0.245
Brugia malayi Protein kinase domain containing protein 0.0052 0.0022 0.0022
Plasmodium vivax subtilisin-like serine protease, putative 0.0364 0.0352 0.9068
Loa Loa (eye worm) hypothetical protein 0.0136 0.011 0.011
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0103 0.0076 0.0085
Loa Loa (eye worm) hypothetical protein 0.0232 0.0212 0.0212
Loa Loa (eye worm) transcriptional regulator 0.0101 0.0074 0.0074
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0084 0.0055 0.1085
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.006 0.003 0.0052
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0004 0.0004
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0034 0.0003 0.0002
Echinococcus multilocularis discoidin domain containing receptor 2 0.005 0.0019 0.0025
Brugia malayi Kelch motif family protein 0.1487 0.1538 0.1538
Giardia lamblia Transcriptional regulator, Sir2 family 0.0101 0.0074 0.0192
Plasmodium falciparum plasmepsin V 0.0398 0.0387 1
Plasmodium vivax subtilisin-like protease 1 0.0364 0.0352 0.9068
Brugia malayi SWIRM domain containing protein 0.0043 0.0012 0.0012
Trichomonas vaginalis hypothetical protein 0.1647 0.1708 0.3195
Trichomonas vaginalis conserved hypothetical protein 0.0364 0.0352 0.0654
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0364 0.0352 0.0352
Schistosoma mansoni hypothetical protein 0.0059 0.0029 0.0032
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0232 0.0212 0.024
Echinococcus granulosus glutamate NMDA receptor subunit 0.0273 0.0255 0.029
Loa Loa (eye worm) hypothetical protein 0.1163 0.1196 0.1196
Toxoplasma gondii type I fatty acid synthase, putative 0.0089 0.0061 0.1671
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0035 0.0004 0.0004
Loa Loa (eye worm) WD40 repeat protein 0.0071 0.0042 0.0042
Mycobacterium ulcerans monoamine oxidase 0.0103 0.0076 0.1578
Trichomonas vaginalis alpha-L-fucosidase, putative 0.005 0.0019 0.0031
Brugia malayi Stress-activated protein kinase jnk-1 0.0243 0.0224 0.0224
Echinococcus multilocularis membrane bound transcription factor site 1 0.0364 0.0352 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0012 0.0018
Giardia lamblia Tenascin precursor 0.021 0.0189 0.0552
Brugia malayi protein kinase C II. 0.0106 0.0079 0.0079
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.0004 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Brugia malayi hypothetical protein 0.0103 0.0076 0.0076
Echinococcus multilocularis protein kinase c epsilon type 0.0106 0.0079 0.0106
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0094 0.0066 0.0924
Schistosoma mansoni dock 0.005 0.0019 0.0021
Loa Loa (eye worm) raf kinase 0.0507 0.0502 0.0502
Schistosoma mansoni chromatin regulatory protein sir2 0.0686 0.0692 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Loa Loa (eye worm) TK/EGFR protein kinase 0.0467 0.0461 0.0461
Echinococcus multilocularis adam 0.0513 0.0509 0.069
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0084 0.0055 0.1085
Loa Loa (eye worm) hypothetical protein 0.0091 0.0063 0.0063
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.0019 0.002
Mycobacterium ulcerans polyketide synthase 0.0084 0.0055 0.0949
Echinococcus multilocularis protein kinase c iota type 0.0033 0.0002 0.0002
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0096 0.0068 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.005 0.0019 0.0025
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.021 0.0189 0.0349
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0074 0.0133
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.0076 0.1061
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0101 0.0074 0.0192
Brugia malayi hypothetical protein 0.0094 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0091 0.0063 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Echinococcus granulosus epidermal growth factor receptor 0.0467 0.0461 0.0525
Entamoeba histolytica hypothetical protein 0.0043 0.0012 0.0138
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0076 0.1871
Giardia lamblia High cysteine membrane protein Group 2 0.3072 0.3214 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5083 0.534 0.609
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0127 0.0101 0.2782
Schistosoma mansoni integrin alpha-ps 0.0505 0.05 0.057
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0019 0.0024
Echinococcus granulosus protein kinase c iota type 0.0033 0.0002 0.0001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0103 0.0076 0.0085
Toxoplasma gondii subtilisin SUB2 0.0364 0.0352 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0084 0.0055 0.1477
Plasmodium vivax subtilisin-like protease 2, putative 0.0364 0.0352 0.9068
Brugia malayi EGF-like domain containing protein 0.021 0.0189 0.0189
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0084 0.0055 0.0055
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0364 0.0352 0.04
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0004 0.0004
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0103 0.0076 0.2097
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0101 0.0074 0.1032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0015 0.0015
Brugia malayi proprotein convertase 2 0.5254 0.552 0.552
Loa Loa (eye worm) hypothetical protein 0.0825 0.0839 0.0839
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0084 0.0056 0.149
Brugia malayi Reprolysin 0.0136 0.011 0.011
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0089 0.0061 0.1641
Trichomonas vaginalis hypothetical protein 0.005 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0508 0.0503 0.0503
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1163 0.1196 0.1196
Echinococcus granulosus MAM 0.0091 0.0063 0.007
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0049 0.0019 0.0433
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0089 0.0061 0.1256
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Echinococcus multilocularis neuroendocrine convertase 2 0.5254 0.552 0.7488
Echinococcus multilocularis protoporphyrinogen oxidase 0.0103 0.0076 0.0102
Toxoplasma gondii hypothetical protein 0.021 0.0189 0.5341
Schistosoma mansoni dihydroceramide desaturase 0.0096 0.0068 0.0077
Schistosoma mansoni integrin alpha 0.1666 0.1728 0.197
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0004 0.0004
Echinococcus multilocularis protein arginine N methyltransferase 8 0.006 0.003 0.004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0364 0.0352 0.0654
Brugia malayi Will die slowly protein 0.0071 0.0042 0.0042
Echinococcus granulosus nmda type glutamate receptor 0.0115 0.0089 0.01
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0019 0.0031
Echinococcus granulosus neuroendocrine convertase 2 0.5254 0.552 0.6296
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0012
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.01 0.0072 0.0072
Brugia malayi angiogenesis inhibito 0.0136 0.011 0.011
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0089 0.0061 0.1256
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0101 0.0074 0.1818
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0044 0.0049
Schistosoma mansoni protein arginine N-methyltransferase 1 0.006 0.003 0.0034
Echinococcus granulosus c-Jun N-terminal kinases 0.0243 0.0224 0.0254
Brugia malayi NAD-dependent deacetylase SIRT1 0.0101 0.0074 0.0074
Schistosoma mansoni protein arginine N-methyltransferase 1 0.006 0.003 0.0034
Echinococcus multilocularis 0.6679 0.7027 0.9531
Schistosoma mansoni furin-1 (S08 family) 0.3607 0.3779 0.431
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1647 0.1708 0.3195
Schistosoma mansoni integrin alpha-ps 0.0841 0.0855 0.0974
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0074 0.0133
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0101 0.0074 0.1032

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM Antagonist activity at human recombinant C5a receptor in U937 cells assessed as inhibition of C5a-induced calcium mobilization by FLIPR assay ChEMBL. 18595693

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.