Detailed information for compound 994205

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 538.058 | Formula: C28H28ClN3O4S
  • H donors: 1 H acceptors: 4 LogP: 4.1 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)CN1C(=O)c2ccccc2S(=O)(=O)c2c1cc(cc2)C(=O)NCCCN1CCCC1
  • InChi: 1S/C28H28ClN3O4S/c29-22-11-8-20(9-12-22)19-32-24-18-21(27(33)30-14-5-17-31-15-3-4-16-31)10-13-26(24)37(35,36)25-7-2-1-6-23(25)28(32)34/h1-2,6-13,18H,3-5,14-17,19H2,(H,30,33)
  • InChiKey: RKOSERSRNKFCCZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0382 0.1177
Brugia malayi cytochrome P450 0.0014 0.0102 0.0362
Echinococcus multilocularis calcium dependent protein kinase 0.0013 0.0085 0.0047
Trichomonas vaginalis esterase, putative 0.0031 0.0382 0.133
Loa Loa (eye worm) cytochrome P450 0.0014 0.0102 0.0231
Mycobacterium tuberculosis Conserved protein 0.0031 0.0382 0.119
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.001 0.0047 0.0021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0164 0.0461
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0281 0.083
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0164 0.0125
Loa Loa (eye worm) hypothetical protein 0.0023 0.0251 0.0781
Leishmania major glucose transporter, lmgt2 0.0014 0.0102 0.0155
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0172 0.2685 0.9771
Leishmania major mitochondrial DNA polymerase beta 0.0259 0.4112 1
Onchocerca volvulus 0.0049 0.067 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0102 0.0231
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0014 0.0099 0.0222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0574 0.0537
Loa Loa (eye worm) hypothetical protein 0.0023 0.0258 0.0807
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0051 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0148 0.0359
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0574 0.2227
Trypanosoma brucei glucose transporter, putative 0.0014 0.0102 0.0155
Mycobacterium tuberculosis Probable dehydrogenase 0.0069 0.0997 0.3183
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0176 0.2748 1
Echinococcus multilocularis lamin 0.0023 0.0258 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0102 0.0282
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0014 0.0099 0.006
Plasmodium vivax CDK-related protein kinase 6, putative 0.0188 0.2953 1
Leishmania major hypothetical protein, conserved 0.0031 0.0382 0.0842
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0574 0.2227
Brugia malayi Cytochrome P450 family protein 0.0059 0.0835 0.3034
Loa Loa (eye worm) hypothetical protein 0.0176 0.2748 1
Trichomonas vaginalis mercuric reductase, putative 0.001 0.0047 0.0104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0047 0.0115
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0164 0.0483
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0102 0.0282
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0382 0.0929
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0102 0.0247
Echinococcus granulosus hemicentin 1 0.0049 0.067 0.2624
Brugia malayi Cytochrome P450 family protein 0.002 0.0211 0.076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0164 0.0398
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0505 0.1831
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0025 0.0281 0.0893
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0036 0.0473 0.1149
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0148 0.0267
Echinococcus granulosus low density lipoprotein receptor ldl 0.0049 0.067 0.2624
Loa Loa (eye worm) hypothetical protein 0.0014 0.0099 0.0222
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0036 0.0473 0.1149
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0044 0.0602 0.2343
Echinococcus multilocularis General substrate transporter 0.0038 0.05 0.0463
Brugia malayi cytoplasmic intermediate filament protein 0.0012 0.0081 0.0287
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0044 0.0602 0.2343
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0016 0.0131 0.0318
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0102 0.0231
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0013 0.0095 0.0056
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0164 0.0461
Trypanosoma brucei glucose transporter, putative 0.0014 0.0102 0.0155
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0102 0.0231
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0011 0.0051 0.0178
Leishmania major glucose transporter, lmgt1 0.0014 0.0102 0.0155
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0014 0.0099 0.025
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0014 0.0099 0.0223
Loa Loa (eye worm) sugar transporter 0.0044 0.0602 0.2079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0055
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0148 0.0402
Leishmania major cytochrome p450-like protein 0.0014 0.0102 0.0154
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0102 0.0231
Brugia malayi Sugar transporter family protein 0.0044 0.0602 0.2185
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0176 0.2748 1
Schistosoma mansoni ap endonuclease 0.0018 0.0164 0.0519
Trichomonas vaginalis CAMK family protein kinase 0.0014 0.0099 0.0294
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.001 0.0047 0.0029
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0014 0.0099 0.0207
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0044 0.0602 0.2343
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0014 0.0099 0.0223
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0102 0.0154
Trichomonas vaginalis glutathione reductase, putative 0.001 0.0047 0.0104
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0102 0.0231
Brugia malayi Cytochrome P450 family protein 0.002 0.0211 0.076
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0014 0.0099 0.025
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0505 0.1228
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0102 0.0231
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0069 0.0997 0.368
Trypanosoma brucei glucose transporter 2A 0.0014 0.0102 0.0155
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0281 0.0594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0574 0.2227
Schistosoma mansoni protein kinase 0.0014 0.0099 0.025
Giardia lamblia Synaptic glycoprotein SC2 0.0025 0.0281 1
Schistosoma mansoni hypothetical protein 0.0014 0.0102 0.0261
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.001 0.0047 0.0029
Leishmania major DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Plasmodium falciparum protein kinase 6 0.0188 0.2953 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0102 0.0282
Leishmania major hypothetical protein, conserved 0.0011 0.0051 0.003
Mycobacterium tuberculosis Probable esterase LipL 0.0031 0.0382 0.119
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0025 0.0281 0.096
Giardia lamblia DINP protein human, muc B family 0.0017 0.0148 0.4497
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0574 0.0537
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0064 0.0061
Toxoplasma gondii thioredoxin reductase 0.003 0.0368 0.1216
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0014 0.0099 0.0207
Loa Loa (eye worm) hypothetical protein 0.0013 0.0095 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0102 0.0282
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0044 0.0602 0.0565
Plasmodium vivax thioredoxin reductase, putative 0.003 0.0368 0.113
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0148 0.0453
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0164 0.0589
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0044 0.0602 0.2343
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0102 0.0282
Treponema pallidum hypothetical protein 0.0172 0.2685 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0505 0.172
Trypanosoma brucei THT1 - hexose transporter, putative 0.0014 0.0102 0.0155
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0164 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0574 0.1976
Echinococcus granulosus geminin 0.0157 0.2442 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0281 0.096
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Leishmania major trypanothione reductase 0.003 0.0368 0.0809
Loa Loa (eye worm) thioredoxin reductase 0.003 0.0368 0.1216
Trypanosoma brucei unspecified product 0.0017 0.0148 0.0267
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0102 0.0231
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0102 0.0231
Echinococcus multilocularis beta LACTamase domain containing family member 0.0031 0.0382 0.0344
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0603 0.1466
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0102 0.0282
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0281 0.0683
Plasmodium falciparum calcium-dependent protein kinase 5 0.0014 0.0099 0.0207
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0258 0.0807
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0102 0.0231
Echinococcus granulosus contactin 0.0049 0.067 0.2624
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0076 0.1122 0.3588
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0164 0.0428
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0011 0.0051 0.0012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.001 0.0047 0.0031
Trypanosoma brucei glucose transporter 1E 0.0014 0.0102 0.0155
Plasmodium falciparum thioredoxin reductase 0.003 0.0368 0.113
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0031 0.0382 0.119
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Plasmodium falciparum protein kinase 7 0.0125 0.1925 0.6471
Trypanosoma brucei glucose transporter, putative 0.0014 0.0102 0.0155
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0102 0.0304
Plasmodium falciparum calcium-dependent protein kinase 4 0.0014 0.0099 0.0207
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0164 0.0441
Echinococcus granulosus lamin dm0 0.0023 0.0258 0.091
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0835 0.294
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0049 0.067 0.2624
Loa Loa (eye worm) hypothetical protein 0.0031 0.0382 0.1266
Plasmodium falciparum hexose transporter 0.0044 0.0602 0.1932
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0382 0.0929
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0016 0.0131 0.0225
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0011 0.0051 0.0118
Brugia malayi Cam kinase protein 1 0.0014 0.0099 0.0353
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0014 0.0099 0.0222
Mycobacterium leprae putative cytochrome p450 0.0014 0.0102 0.0326
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0069 0.0997 0.3183
Loa Loa (eye worm) hypothetical protein 0.0031 0.0382 0.1266
Plasmodium falciparum calcium-dependent protein kinase 2 0.0014 0.0099 0.0207
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0211 0.0513
Leishmania major dihydrolipoamide dehydrogenase, putative 0.001 0.0047 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0102 0.0282
Schistosoma mansoni protein kinase 0.0014 0.0099 0.025
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0011 0.0051 0.0042
Mycobacterium tuberculosis Probable reductase 0.0069 0.0997 0.3183
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0102 0.0282
Entamoeba histolytica protein kinase, putative 0.0014 0.0099 0.0222
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0013 0.0095 0.0232
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0025 0.0281 0.096
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.001 0.0047 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Echinococcus granulosus lamin 0.0023 0.0258 0.091
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0176 0.2748 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0013 0.0095 0.0232
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0382 0.133
Brugia malayi Synaptic glycoprotein SC2 0.0025 0.0281 0.1015
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0011 0.0051 0.0118
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0148 0.0453
Brugia malayi Thioredoxin reductase 0.003 0.0368 0.1333
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0148 0.0359
Echinococcus granulosus intermediate filament protein 0.0023 0.0258 0.091
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0176 0.2748 0.6682
Echinococcus granulosus synaptic glycoprotein sc2 0.0025 0.0281 0.1007
Leishmania major glucose transporter, lmgt3 0.0014 0.0102 0.0155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0047 0.0115
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0102 0.0247
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.001 0.0047 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0259 0.4112 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Toxoplasma gondii protein kinase, putative 0.0125 0.1925 0.6963
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0211 0.0513
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0102 0.0231
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0164 0.0307
Trypanosoma brucei cytochrome P450, putative 0.002 0.0211 0.0422
Echinococcus multilocularis 0.0014 0.0102 0.0063
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0011 0.0051 0.0045
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0011 0.0051 0.0051
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0258 0.093
Trypanosoma brucei glucose transporter, putative 0.0014 0.0102 0.0155
Mycobacterium leprae Probable lipase LipE 0.0031 0.0382 0.1376
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0602 0.2137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0047 0.0115
Brugia malayi hypothetical protein 0.0049 0.067 0.2431
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0011 0.0061 0.0022
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0049 0.067 0.0633
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0031 0.0382 0.1383
Brugia malayi intermediate filament protein 0.0023 0.0258 0.093
Schistosoma mansoni hypothetical protein 0.0011 0.0049 0.0042
Schistosoma mansoni hypothetical protein 0.0044 0.0602 0.2343
Echinococcus multilocularis lamin dm0 0.0023 0.0258 0.0219
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0176 0.2748 1
Trichomonas vaginalis dullard protein, putative 0.0011 0.0051 0.0118
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0027 0.0318 0.1031
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.001 0.0047 0.0035
Onchocerca volvulus 0.0031 0.0382 0.3019
Trichomonas vaginalis DNA polymerase eta, putative 0.0017 0.0148 0.0472
Leishmania major glucose transporter/membrane transporter D2, putative 0.0014 0.0102 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0281 0.096
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0123 0.1881 0.4523
Plasmodium falciparum glutathione reductase 0.003 0.0368 0.113
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0102 0.0282
Mycobacterium tuberculosis Conserved hypothetical protein 0.0137 0.2108 0.6779
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0011 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0045
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0148 0.0267
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0148 0.0359
Leishmania major cytochrome p450-like protein 0.0014 0.0102 0.0154
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0031 0.0382 0.119
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0013 0.0095 0.0337
Trypanosoma brucei glucose transporter, putative 0.0014 0.0102 0.0155
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0164 0.0519
Brugia malayi Cytochrome P450 family protein 0.0014 0.0102 0.0362
Onchocerca volvulus 0.0049 0.067 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0382 0.1266
Echinococcus multilocularis geminin 0.0157 0.2442 0.2413
Echinococcus multilocularis dna polymerase kappa 0.0017 0.0148 0.0109
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0044 0.0602 0.0565
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0047 0.0115
Plasmodium vivax proline--tRNA ligase, putative 0.0016 0.0131 0.0315
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0148 0.0431
Plasmodium falciparum calcium-dependent protein kinase 3 0.0014 0.0099 0.0207
Onchocerca volvulus 0.0025 0.0281 0.0566
Mycobacterium ulcerans beta-lactamase 0.0031 0.0382 0.1266
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0102 0.0231
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0382 0.133
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0025 0.0281 0.0893
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0.0081 0.0155
Toxoplasma gondii exonuclease III APE 0.0018 0.0164 0.0461
Mycobacterium tuberculosis Probable oxidoreductase 0.0076 0.1122 0.3588
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0011 0.0051 0.0042
Brugia malayi beta-lactamase 0.0031 0.0382 0.1383
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0102 0.0248
Plasmodium vivax glutathione reductase, putative 0.003 0.0368 0.113
Schistosoma mansoni glucose transport protein 0.0044 0.0602 0.2343
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0049 0.067 1
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0011 0.0051 0.0045
Echinococcus granulosus dna polymerase kappa 0.0017 0.0148 0.0453
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0014 0.0099 0.025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0574 0.2227
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.003 0.0368 0.1145
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0025 0.0281 0.1007
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0382 0.133
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.001 0.0039 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0281 0.0893
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0148 0.0431
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0102 0.0304
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0176 0.2748 1
Leishmania major DNA polymerase eta, putative 0.0027 0.0318 0.0686
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0148 0.0453
Trypanosoma brucei trypanothione reductase 0.003 0.0368 0.0809
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0259 0.4112 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0148 0.0402
Schistosoma mansoni hypothetical protein 0.0157 0.2442 1
Schistosoma mansoni hypothetical protein 0.0049 0.067 0.2624
Mycobacterium tuberculosis Conserved protein 0.0031 0.0382 0.119
Toxoplasma gondii NADPH-glutathione reductase 0.001 0.0047 0.0031
Onchocerca volvulus 0.0031 0.0382 0.3019
Entamoeba histolytica protein kinase, putative 0.0014 0.0099 0.0222
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0258 0.0807
Mycobacterium tuberculosis Probable lipase LipE 0.0031 0.0382 0.119
Mycobacterium tuberculosis Conserved protein 0.0031 0.0382 0.119
Loa Loa (eye worm) hypothetical protein 0.0031 0.0382 0.1266
Trypanosoma brucei unspecified product 0.0011 0.0064 0.0061
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0102 0.0304
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0102 0.0231
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0164 0.0428
Plasmodium falciparum mitogen-activated protein kinase 2 0.0072 0.1048 0.3464
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.001 0.0047 0.0029
Brugia malayi glutathione reductase 0.003 0.0368 0.1333
Schistosoma mansoni lamin 0.0023 0.0258 0.091
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0011 0.0051 0.003
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0176 0.2748 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0164 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0102 0.0304
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0102 0.0304
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0011 0.0061 0.0091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0047 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.008
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0382 0.1376
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0031 0.0382 0.119
Loa Loa (eye worm) hypothetical protein 0.0025 0.0281 0.0893
Echinococcus granulosus thioredoxin glutathione reductase 0.003 0.0375 0.1397
Onchocerca volvulus 0.0031 0.0382 0.3019
Onchocerca volvulus Netrin receptor homolog 0.0049 0.067 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.001 0.0047 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0031 0.0382 0.119
Onchocerca volvulus 0.0049 0.067 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0102 0.0231
Plasmodium vivax polyprenol reductase, putative 0.0025 0.0281 0.083
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.001 0.0039 0.0073
Mycobacterium ulcerans hypothetical protein 0.0176 0.2748 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0016 0.0131 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0382 0.133
Plasmodium falciparum calcium-dependent protein kinase 1 0.0014 0.0099 0.0207
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0014 0.0099 0.0223
Trypanosoma brucei glucose transporter, putative 0.0014 0.0102 0.0155
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0102 0.0304
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0011 0.0051 0.0504
Entamoeba histolytica hypothetical protein 0.0025 0.0281 0.0893
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0014 0.0099 0.025
Loa Loa (eye worm) beta-lactamase 0.0031 0.0382 0.1266
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0072 0.1048 0.3727
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0176 0.2748 0.6682
Echinococcus multilocularis dna polymerase eta 0.0038 0.0505 0.0468
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0072 0.1048 0.3464
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0016 0.0131 0.0318
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.001 0.0047 0.0029
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0013 0.0095 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0281 0.096
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0025 0.0281 0.096
Trypanosoma brucei THT1 - hexose transporter, putative 0.0014 0.0102 0.0155
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.001 0.0047 0.0021
Echinococcus multilocularis thioredoxin glutathione reductase 0.003 0.0375 0.0337
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0025 0.0281 0.0893
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0025 0.0281 0.1007
Trichomonas vaginalis dullard protein, putative 0.0011 0.0051 0.0118
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0011 0.0051 0.0118
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0025 0.0281 0.0243
Leishmania major dihydrolipoamide dehydrogenase, putative 0.001 0.0047 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0148 0.0402
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0055
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0148 0.0402
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.001 0.0047 0.0115
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0164 0.0307
Loa Loa (eye worm) hypothetical protein 0.0031 0.0382 0.1266
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0123 0.1881 0.4575
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0013 0.0095 0.0277
Brugia malayi lysyl-tRNA synthetase 0.001 0.0039 0.0134
Leishmania major protein kinase, putative 0.0014 0.0099 0.0148
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0148 0.0359
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0211 0.0635
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0014 0.0099 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.001 0.0039 0.0095
Schistosoma mansoni titin 0.0049 0.067 0.2624
Trypanosoma cruzi DNA polymerase eta, putative 0.0027 0.0318 0.0774
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0102 0.0282
Onchocerca volvulus Putative titin 0.0049 0.067 1
Mycobacterium ulcerans esterase/lipase LipP 0.0031 0.0382 0.1266
Trypanosoma cruzi trypanothione reductase, putative 0.001 0.0047 0.0115
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0014 0.0099 0.0353
Toxoplasma gondii ABC1 family protein 0.0031 0.0382 0.1266
Plasmodium falciparum proline--tRNA ligase 0.0016 0.0131 0.0315
Echinococcus granulosus CTD small phosphatase protein like 0.0011 0.0051 0.0051
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0013 0.0095 0.03
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0016 0.0131 0.0225
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0164 0.0531
Loa Loa (eye worm) glutathione reductase 0.003 0.0368 0.1216
Plasmodium falciparum thioredoxin reductase 0.001 0.0047 0.0029
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0102 0.0282
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.001 0.0047 0.0165
Trypanosoma brucei glucose transporter, putative 0.0014 0.0102 0.0155
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0211 0.0635
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0014 0.0099 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0382 0.1427
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0102 0.0304
Mycobacterium ulcerans flavoprotein disulfide reductase 0.001 0.0047 0.0031
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0102 0.0248
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0172 0.2685 0.9081
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0016 0.0131 0.0339
Trypanosoma brucei unspecified product 0.0011 0.0064 0.0061
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.001 0.0047 0.0031
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0102 0.0282
Trypanosoma brucei THT1 - hexose transporter, putative 0.0014 0.0102 0.0155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0047 0.0115
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0102 0.0282
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0102 0.0154
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0044 0.0602 0.0565
Schistosoma mansoni intermediate filament proteins 0.0023 0.0258 0.091
Giardia lamblia NADH oxidase lateral transfer candidate 0.001 0.0047 0.0347
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0102 0.0282
Schistosoma mansoni cytochrome P450 0.0014 0.0102 0.0261
Toxoplasma gondii hypothetical protein 0.0042 0.056 0.1924
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0102 0.0231
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0011 0.0051 0.0051
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0102 0.0248
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0172 0.2685 0.865
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0102 0.0282
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0102 0.0231
Schistosoma mansoni hypothetical protein 0.0157 0.2442 1
Echinococcus multilocularis musashi 0.0023 0.0258 0.0219
Leishmania major acetoin dehydrogenase e3 component-like protein 0.001 0.0047 0.0021
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0102 0.0261
Echinococcus granulosus beta LACTamase domain containing family member 0.0031 0.0382 0.1427
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0076 0.1122 0.4148
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.001 0.0047 0.0021
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0069 0.0997 0.3183
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0017 0.0148 0.0472
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0014 0.0099 0.006
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0102 0.0231
Mycobacterium ulcerans hypothetical protein 0.0031 0.0382 0.1266
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0382 0.133
Echinococcus multilocularis synaptic glycoprotein sc2 0.0025 0.0281 0.0243
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0102 0.0231
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0044 0.0602 0.0565
Schistosoma mansoni glucose transport protein 0.0044 0.0602 0.2343
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0102 0.0247
Giardia lamblia Prolyl-tRNA synthetase 0.0013 0.0095 0.2301
Trypanosoma cruzi hexose transporter 0.0014 0.0102 0.0248
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0102 0.0231
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0164 0.516
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0036 0.0473 0.1065
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0368 0.0896
Schistosoma mansoni lamin 0.0023 0.0258 0.091
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0148 0.0267
Toxoplasma gondii facilitative glucose transporter GT1 0.0044 0.0602 0.2079
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0011 0.0051 0.0042
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0014 0.0099 0.006
Mycobacterium tuberculosis Probable lipase LipD 0.0031 0.0382 0.119
Echinococcus multilocularis hemicentin 1 0.0049 0.067 0.0633
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0102 0.0282
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.001 0.0047 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0064 0.0061
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0102 0.0231
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0164 0.0531
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0176 0.2748 0.6651
Trypanosoma brucei glucose transporter, putative 0.0014 0.0102 0.0155
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0102 0.0326
Schistosoma mansoni DNA polymerase eta 0.0038 0.0505 0.1939
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0382 0.0842
Plasmodium vivax calcium-dependent protein kinase, putative 0.0014 0.0099 0.0207
Schistosoma mansoni ap endonuclease 0.0018 0.0164 0.0519
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0172 0.2685 0.9081
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0102 0.0282
Plasmodium falciparum glutathione reductase 0.001 0.0047 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0099 0.025
Mycobacterium ulcerans hypothetical protein 0.0137 0.2108 0.7637
Onchocerca volvulus Tyrosine kinase homolog 0.0049 0.067 1
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0172 0.2685 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0382 0.1266
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0036 0.0473 0.1149
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0025 0.0281 0.0893
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0102 0.0282
Trichomonas vaginalis dullard protein, putative 0.0011 0.0051 0.0118
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0176 0.2748 0.6651
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0211 0.0635
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0382 0.1427
Echinococcus multilocularis 0.0011 0.0051 0.0012
Schistosoma mansoni protein kinase 0.0014 0.0099 0.025
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0069 0.0997 0.3183
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0148 0.0109
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0013 0.0095 0.0232
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0164 0.0461
Plasmodium vivax hexose transporter 0.0044 0.0602 0.1932
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0076 0.1122 0.3588
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0259 0.4112 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0505 0.1144
Loa Loa (eye worm) hypothetical protein 0.0049 0.067 0.2328
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0148 0.053
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0014 0.0099 0.0148
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0102 0.0231
Loa Loa (eye worm) hypothetical protein 0.0013 0.0095 0.0206
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0025 0.0281 0.1007
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0102 0.0231
Echinococcus granulosus dna polymerase eta 0.0038 0.0505 0.1939
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0197 0.3102 1
Schistosoma mansoni glucose transport protein 0.0044 0.0602 0.2343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0574 0.2227
Echinococcus granulosus General substrate transporter 0.0038 0.05 0.1919
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0574 0.2084
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0148 0.0267
Brugia malayi beta-lactamase family protein 0.0031 0.0382 0.1383
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.001 0.0047 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0102 0.0282
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.001 0.0047 0.0035
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.001 0.0047 0.0115
Leishmania major cytochrome p450-like protein 0.002 0.0211 0.0422
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0069 0.0997 0.3183
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0505 0.1144
Onchocerca volvulus 0.0049 0.067 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0123 0.1881 0.4523
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0031 0.0382 0.1266
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0013 0.0095 0.0337
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0148 0.0267
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0011 0.0051 0.0118
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0102 0.0282
Echinococcus granulosus calcium dependent protein kinase 0.0013 0.0085 0.0193
Plasmodium falciparum polyprenol reductase, putative 0.0025 0.0281 0.083
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0064 0.0061
Brugia malayi beta-lactamase family protein 0.0031 0.0382 0.1383
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0031 0.0382 0.1266
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0281 0.083
Mycobacterium ulcerans lipase LipD 0.0031 0.0382 0.1266
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.001 0.0047 0.0031
Loa Loa (eye worm) CYP4Cod1 0.002 0.0211 0.0635

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.25 mM Inhibition of Mycobacterium tuberculosis recombinant MshC assessed as production of Cys-GlcN-Ins from cysteine by HPLC based fluorescence assay ChEMBL. 21665483

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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