Detailed information for compound 1030953

Basic information

Technical information
  • TDR Targets ID: 1030953
  • Name: (2R)-2-[4-[4-[2-[(2,2-dimethyl-1,3-benzodioxo l-5-yl)methyl]-1-benzothiophen-3-yl]phenyl]ph enoxy]-3-phenylpropanoic acid
  • MW: 612.733 | Formula: C39H32O5S
  • H donors: 1 H acceptors: 2 LogP: 10.14 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H](Cc1ccccc1)Oc1ccc(cc1)c1ccc(cc1)c1c(Cc2ccc3c(c2)OC(O3)(C)C)sc2c1cccc2
  • InChi: 1S/C39H32O5S/c1-39(2)43-32-21-12-26(23-33(32)44-39)24-36-37(31-10-6-7-11-35(31)45-36)29-15-13-27(14-16-29)28-17-19-30(20-18-28)42-34(38(40)41)22-25-8-4-3-5-9-25/h3-21,23,34H,22,24H2,1-2H3,(H,40,41)/t34-/m1/s1
  • InChiKey: RMIUMNASYHPGOQ-UUWRZZSWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-2-[4-[4-[2-[(2,2-dimethyl-1,3-benzodioxol-5-yl)methyl]benzothiophen-3-yl]phenyl]phenoxy]-3-phenyl-propanoic acid
  • (2R)-2-[4-[4-[2-[(2,2-dimethyl-1,3-benzodioxol-5-yl)methyl]-3-benzothiophenyl]phenyl]phenoxy]-3-phenylpropanoic acid
  • (2R)-2-[4-[4-[2-[(2,2-dimethyl-1,3-benzodioxol-5-yl)methyl]benzothiophen-3-yl]phenyl]phenoxy]-3-phenyl-propionic acid
  • (2R)-2-[4-[4-[2-[(2,2-dimethyl-1,3-benzodioxol-5-yl)methyl]-1-benzothiophen-3-yl]phenyl]phenoxy]-3-phenyl-propanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein tyrosine phosphatase, non-receptor type 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma japonicum ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative Get druggable targets OG5_133865 All targets in OG5_133865
Echinococcus multilocularis tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865
Echinococcus granulosus tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865
Loa Loa (eye worm) protein-tyrosine phosphatase Get druggable targets OG5_133865 All targets in OG5_133865
Brugia malayi Protein-tyrosine phosphatase containing protein Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma japonicum expressed protein Get druggable targets OG5_133865 All targets in OG5_133865
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0037 0.0439 0.0606
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0282 0.1149
Mycobacterium leprae conserved hypothetical protein 0.0091 0.1391 0.9302
Entamoeba histolytica protein kinase , putative 0.0042 0.0534 0.1444
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0042 0.0047
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0071 0.0084
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0025 0.0234 0.032
Loa Loa (eye worm) TAR-binding protein 0.0164 0.2681 0.3687
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0091 0.1391 0.1915
Trypanosoma brucei glucosidase, putative 0.0026 0.0257 0.1044
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0423 0.7262 0.906
Trichomonas vaginalis D-aminoacylase, putative 0.0091 0.1391 0.1931
Brugia malayi hypothetical protein 0.0014 0.0037 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.1391 0.5733
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0234 0.0287
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.2691 0.3702
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0088
Mycobacterium tuberculosis Conserved protein 0.0091 0.1391 0.1381
Mycobacterium tuberculosis Conserved protein 0.0091 0.1391 0.1381
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0025 0.0231 0.1483
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0011 0.0028
Schistosoma mansoni inositol monophosphatase 0.0028 0.0282 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0068 0.008
Brugia malayi Latrophilin receptor protein 2 0.0052 0.071 0.0978
Echinococcus multilocularis neutral alpha glucosidase AB 0.0026 0.0257 0.0315
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0042 0.0534 0.1444
Brugia malayi mbt repeat family protein 0.0039 0.0489 0.0673
Schistosoma mansoni TRABID protein (C64 family) 0.0149 0.2423 0.3019
Brugia malayi Inositol-1 0.0028 0.0282 0.0388
Echinococcus multilocularis beta LACTamase domain containing family member 0.0091 0.1391 0.1731
Trichomonas vaginalis penicillin-binding protein, putative 0.0091 0.1391 0.1931
Trypanosoma brucei hypothetical protein, conserved 0.0091 0.1391 0.5733
Plasmodium vivax SET domain protein, putative 0.0043 0.0555 0.0767
Echinococcus granulosus microtubule associated protein 2 0.0466 0.8015 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0041 0.0516 0.064
Leishmania major hypothetical protein, conserved 0.0091 0.1391 0.5733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0068 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0068 0.0088
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0094 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0068 0.0088
Schistosoma mansoni fusion 0.0149 0.2423 0.3019
Mycobacterium tuberculosis Conserved protein 0.0091 0.1391 0.1381
Brugia malayi serine/threonine-protein kinase 6 0.0042 0.0534 0.0735
Onchocerca volvulus 0.0419 0.7186 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0039 0.0477 0.059
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0257 0.0352
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.1774 0.2443
Plasmodium falciparum serine/threonine protein kinase, putative 0.0042 0.0534 0.0738
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.0257 0.0352
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0071 0.0098
Schistosoma mansoni rab6-interacting 0.0014 0.0037 0.0041
Giardia lamblia Fructose-bisphosphate aldolase 0.0197 0.3276 1
Schistosoma mansoni polycystin 1-related 0.0014 0.0037 0.0041
Brugia malayi steroid hormone receptor 0.0016 0.0068 0.0093
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0297 0.5038 0.6936
Loa Loa (eye worm) hypothetical protein 0.0149 0.2423 0.3333
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0025 0.0234 0.0287
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0149 0.2423 0.3336
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0051 0.07 0.0869
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0079 0.1188 0.1477
Loa Loa (eye worm) hypothetical protein 0.0091 0.1391 0.1911
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0264
Brugia malayi Doublecortin family protein 0.0014 0.0037 0.0051
Loa Loa (eye worm) hypothetical protein 0.0091 0.1391 0.1911
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0197 0.3276 0.4555
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0088
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0068 0.0088
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0091 0.1391 0.1911
Schistosoma mansoni brg-1 associated factor 0.0419 0.7186 0.8965
Echinococcus multilocularis inositol monophosphatase 1 0.0028 0.0282 0.0347
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0025 0.0231 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.07 0.2226
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0042 0.0534 0.0738
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0042 0.0534 0.1444
Giardia lamblia TCP-1 chaperonin subunit beta 0.0037 0.0439 0.1149
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0068 0.008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0091 0.1391 0.4458
Loa Loa (eye worm) MBCTL1 0.0045 0.0585 0.08
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0011 0.0028
Trichomonas vaginalis chaperonin, putative 0.0037 0.0439 0.0606
Schistosoma mansoni zinc finger protein 0.002 0.015 0.0182
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0419 0.7186 1
Onchocerca volvulus 0.0043 0.0555 0.0724
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0079 0.1188 0.1477
Trypanosoma brucei ISWI complex protein 0.0013 0.0016 0.005
Echinococcus granulosus caspase 2 0.004 0.0495 0.0613
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0068 0.008
Leishmania major hypothetical protein, conserved 0.0149 0.2423 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0068 0.008
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0423 0.7262 0.906
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0091 0.1391 0.1381
Trypanosoma brucei aurora B kinase 0.0042 0.0534 0.2191
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0011 0.0028
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0053 0.0735 0.0912
Plasmodium falciparum histone acetyltransferase GCN5 0.0027 0.0266 0.0365
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0068 0.0093
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0068 0.008
Schistosoma mansoni tar DNA-binding protein 0.0164 0.2681 0.3341
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0068 0.008
Loa Loa (eye worm) hypothetical protein 0.0025 0.0234 0.0317
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0197 0.3276 0.4555
Brugia malayi beta-lactamase family protein 0.0091 0.1391 0.1915
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0083 0.1251 0.1557
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0068 0.0093
Echinococcus granulosus Zinc finger RanBP2 type 0.0149 0.2423 0.3019
Onchocerca volvulus 0.0338 0.5762 0.8008
Mycobacterium ulcerans hypothetical protein 0.0091 0.1391 0.4458
Brugia malayi Pre-SET motif family protein 0.0297 0.5038 0.6938
Plasmodium vivax hypothetical protein, conserved 0.0091 0.1391 0.1931
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0257 0.1044
Schistosoma mansoni lipoxygenase 0.0058 0.0813 0.1009
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0025 0.0234 0.0507
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0051 0.07 0.0869
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0012 0.0004 0.0006
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0025 0.0234 0.095
Schistosoma mansoni DNA polymerase eta 0.0016 0.0071 0.0084
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0837 0.116
Brugia malayi hypothetical protein 0.0028 0.0284 0.0391
Echinococcus multilocularis apoptotic protease activating factor 1 0.0028 0.0284 0.035
Echinococcus multilocularis polycomb protein SCMH1 0.0039 0.0489 0.0605
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0039 0.0489 0.0605
Echinococcus granulosus lipoxygenase domain containing protein 0.0014 0.0037 0.0041
Leishmania major DNA polymerase eta, putative 0.0016 0.0071 0.0278
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Echinococcus granulosus inositol monophosphatase 1 0.0028 0.0282 0.0347
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0101 0.1581 0.1968
Toxoplasma gondii aldehyde dehydrogenase 0.0051 0.07 0.0969
Loa Loa (eye worm) hypothetical protein 0.0091 0.1391 0.1911
Loa Loa (eye worm) hypothetical protein 0.0057 0.0803 0.1101
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Brugia malayi Cytochrome P450 family protein 0.003 0.0324 0.0446
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0071 0.006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0282 0.1149
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0164 0.2681 0.3687
Loa Loa (eye worm) hypothetical protein 0.0045 0.0585 0.08
Loa Loa (eye worm) hypothetical protein 0.0164 0.2691 0.3702
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.0042 0.0047
Schistosoma mansoni alpha-glucosidase 0.0102 0.1591 0.1981
Schistosoma mansoni alpha-glucosidase 0.0102 0.1591 0.1981
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0803 0.0998
Schistosoma mansoni myelin transcription factor 1 myt1 0.0045 0.0585 0.0725
Echinococcus granulosus caspase 8 0.0012 0.0004 0.000000039254
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0071 0.0084
Brugia malayi beta-lactamase family protein 0.0091 0.1391 0.1915
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0037 0.0439 0.18
Schistosoma mansoni hypothetical protein 0.024 0.402 0.5014
Loa Loa (eye worm) hypothetical protein 0.0149 0.2423 0.3333
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0068 0.008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0068 0.0043
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0068 0.008
Mycobacterium ulcerans lipase LipD 0.0091 0.1391 0.4458
Echinococcus granulosus histone acetyltransferase KAT2B 0.0031 0.0343 0.0424
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0053 0.0735 0.0912
Echinococcus multilocularis lysosomal alpha glucosidase 0.0118 0.1882 0.2344
Loa Loa (eye worm) AUR protein kinase 0.0042 0.0534 0.073
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0477 0.1505
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0068 0.0093
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0423 0.7262 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0071 0.0084
Echinococcus granulosus lysosomal alpha glucosidase 0.0118 0.1882 0.2344
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.2691 0.3706
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.07 0.2226
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0423 0.7262 1
Trichomonas vaginalis D-aminoacylase, putative 0.0091 0.1391 0.1931
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0257 0.1044
Plasmodium vivax multidomain scavenger receptor, putative 0.0014 0.0037 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0071 0.0278
Leishmania major cytochrome p450-like protein 0.0012 0.0011 0.0028
Schistosoma mansoni hypothetical protein 0.0052 0.071 0.0881
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0101 0.1581 0.1968
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0039 0.0477 0.0656
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0149 0.2423 0.3336
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0045 0.0585 0.0725
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0028 0.0282 0.0387
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0043 0.0555 0.0767
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0149 0.2423 0.3019
Brugia malayi PHD-finger family protein 0.0025 0.0228 0.0313
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0031 0.0343 0.0472
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0088
Echinococcus multilocularis 0.0012 0.0011 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0555 0.0688
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0118 0.1882 0.2587
Schistosoma mansoni RNA binding protein 0.0149 0.2423 0.3019
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0071 0.006
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0149 0.2423 0.3019
Onchocerca volvulus 0.0068 0.1001 0.1349
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.0257 0.0353
Brugia malayi hypothetical protein 0.0014 0.0037 0.0051
Echinococcus multilocularis geminin 0.0288 0.4878 0.6083
Echinococcus multilocularis lysosomal alpha glucosidase 0.0118 0.1882 0.2344
Mycobacterium tuberculosis Probable lipase LipE 0.0091 0.1391 0.1381
Echinococcus multilocularis caspase 8 0.0012 0.0004 0.000000039254
Brugia malayi ecdysteroid receptor 0.0016 0.0068 0.0093
Echinococcus multilocularis Polycystic kidney disease protein 0.0014 0.0037 0.0041
Loa Loa (eye worm) T-complex protein 1 0.0037 0.0439 0.06
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0042 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0068 0.0093
Toxoplasma gondii ran binding protein 0.0149 0.2423 0.3368
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0197 0.3276 0.4555
Echinococcus multilocularis lipoxygenase domain containing protein 0.0014 0.0037 0.0041
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0042 0.0534 0.0661
Schistosoma mansoni tar DNA-binding protein 0.0164 0.2681 0.3341
Leishmania major hypothetical protein, conserved 0.0013 0.0016 0.005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0079 0.1188 0.1635
Schistosoma mansoni hypothetical protein 0.0017 0.0094 0.0112
Loa Loa (eye worm) AUR protein kinase 0.0042 0.0534 0.073
Treponema pallidum fructose-bisphosphate aldolase 0.0197 0.3276 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0197 0.3276 0.4555
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0155 0.2533 0.3157
Onchocerca volvulus 0.0016 0.0068 0.0043
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0051 0.07 0.2877
Echinococcus multilocularis tar DNA binding protein 0.0164 0.2681 0.3341
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0257 0.0352
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0071 0.0084
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0149 0.2423 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0012 0.0004 0.000000039254
Trypanosoma brucei hypothetical protein, conserved 0.0149 0.2423 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Giardia lamblia Histone acetyltransferase GCN5 0.0027 0.0266 0.0607
Loa Loa (eye worm) hypothetical protein 0.0039 0.0489 0.0668
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0419 0.7186 0.8965
Loa Loa (eye worm) hypothetical protein 0.0052 0.071 0.0973
Brugia malayi Bromodomain containing protein 0.0034 0.0394 0.0543
Entamoeba histolytica protein kinase, putative 0.0042 0.0534 0.1444
Echinococcus multilocularis SWI:SNF matrix associated 0.0419 0.7186 0.8965
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0257 0.0352
Toxoplasma gondii kinesin motor domain-containing protein 0.0058 0.0818 0.1134
Echinococcus granulosus SWI:SNF matrix associated 0.0419 0.7186 0.8965
Echinococcus multilocularis kinesin family 1 0.0447 0.7685 0.9587
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0197 0.3276 0.4555
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0068 0.0093
Schistosoma mansoni bromodomain containing protein 0.0056 0.0787 0.0977
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0317 0.0391
Loa Loa (eye worm) glutaminase 0.0188 0.3106 0.4274
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0079 0.1188 0.1477
Loa Loa (eye worm) hypothetical protein 0.0112 0.1774 0.2439
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0149 0.2423 0.3368
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0045 0.0585 0.0805
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0534 0.0738
Echinococcus granulosus zinc finger protein 0.002 0.015 0.0182
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0419 0.7186 1
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0068 0.008
Echinococcus multilocularis zinc finger protein Ran binding 0.0149 0.2423 0.3019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0164 0.2681 0.3341
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0282 0.1149
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0091 0.1391 0.1731
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0068 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Echinococcus granulosus apoptotic protease activating factor 1 0.0028 0.0284 0.035
Entamoeba histolytica acetyltransferase, GNAT family 0.0027 0.0266 0.0607
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0234 0.0287
Schistosoma mansoni rab6-interacting 0.0014 0.0037 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0324 0.044
Brugia malayi Cytochrome P450 family protein 0.0012 0.0011 0.0015
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0423 0.7262 0.906
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0149 0.2423 0.3338
Entamoeba histolytica kinesin, putative 0.0058 0.0818 0.2332
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0068 0.0093
Loa Loa (eye worm) beta-lactamase 0.0091 0.1391 0.1911
Schistosoma mansoni alpha glucosidase 0.0026 0.0257 0.0315
Schistosoma mansoni cpg binding protein 0.0031 0.0345 0.0425
Loa Loa (eye worm) hypothetical protein 0.004 0.0495 0.0676
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0071 0.0093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0068 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0197 0.3276 0.4555
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0803 0.0998
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0037 0.0439 0.0544
Brugia malayi nuclear receptor NHR-88 0.0016 0.0068 0.0093
Brugia malayi YY1-associated factor 2 0.0149 0.2423 0.3336
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0317 0.0391
Onchocerca volvulus 0.0023 0.0196 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0068 0.0093
Echinococcus granulosus dna polymerase kappa 0.0016 0.0071 0.0084
Schistosoma mansoni protein kinase 0.0042 0.0534 0.0661
Trichomonas vaginalis sucrase-isomaltase, putative 0.0026 0.0257 0.0352
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.071 0.0881
Schistosoma mansoni coup transcription factor 0.0016 0.0068 0.008
Brugia malayi beta-lactamase 0.0091 0.1391 0.1915
Loa Loa (eye worm) inositol-1 0.0028 0.0282 0.0383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0079 0.1188 0.1477
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0012 0.0011 0.0028
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0025 0.0234 0.032
Schistosoma mansoni kinesin eg-5 0.0058 0.0818 0.1016
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0025 0.0234 0.0507
Brugia malayi serine/threonine kinase 12 0.0042 0.0534 0.0735
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0091 0.1391 0.1381
Echinococcus multilocularis SWI:SNF matrix associated 0.0419 0.7186 0.8965
Echinococcus multilocularis histone acetyltransferase MYST2 0.0045 0.0585 0.0725
Loa Loa (eye worm) kinesin-like protein KLP2 0.0058 0.0818 0.1122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0068 0.0088
Leishmania major hypothetical protein, conserved 0.0149 0.2423 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0353 0.048
Loa Loa (eye worm) hypothetical protein 0.0091 0.1391 0.1911
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0155 0.2533 0.3157
Mycobacterium tuberculosis Probable lipase LipD 0.0091 0.1391 0.1381
Loa Loa (eye worm) hypothetical protein 0.0149 0.2423 0.3333
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0068 0.008
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0031 0.0343 0.0472
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.071 0.0973
Loa Loa (eye worm) mbt repeat family protein 0.0039 0.0489 0.0668
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0012 0.0011 0.0028
Echinococcus granulosus kinesin family 1 0.0447 0.7685 0.9587
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.1391 0.5733
Trichomonas vaginalis penicillin-binding protein, putative 0.0091 0.1391 0.1931
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0036 0.0431 0.0588
Loa Loa (eye worm) hypothetical protein 0.0058 0.0824 0.113
Toxoplasma gondii cytochrome p450 superfamily protein 0.0012 0.0011 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0534 0.0661
Loa Loa (eye worm) MH2 domain-containing protein 0.0099 0.1534 0.2107
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0234 0.0287
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0068 0.008
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.07 0.0869
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.2423 1
Schistosoma mansoni cpg binding protein 0.0031 0.0345 0.0425
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0534 0.0738
Loa Loa (eye worm) transcription factor SMAD2 0.0099 0.1534 0.2107
Onchocerca volvulus 0.0149 0.2423 0.3338
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0096 0.1494 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0068 0.0093
Schistosoma mansoni hypothetical protein 0.0288 0.4878 0.6083
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0028 0.0282 0.5
Schistosoma mansoni hypothetical protein 0.0014 0.0037 0.0041
Brugia malayi SWIB/MDM2 domain containing protein 0.0419 0.7186 0.9895
Leishmania major DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Schistosoma mansoni caspase-7 (C14 family) 0.004 0.0495 0.0613
Schistosoma mansoni hypothetical protein 0.0419 0.7186 0.8965
Chlamydia trachomatis SWIB complex protein 0.0419 0.7186 0.5
Schistosoma mansoni hypothetical protein 0.0419 0.7186 0.8965
Loa Loa (eye worm) hypothetical protein 0.0028 0.0284 0.0386
Toxoplasma gondii ABC1 family protein 0.0091 0.1391 0.1931
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0282 0.0387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0068 0.0088
Brugia malayi brahma associated protein 60 kDa 0.0419 0.7186 0.9895
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0068 0.008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0068 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0045
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0011 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0197 0.3276 0.4555
Schistosoma mansoni tar DNA-binding protein 0.0164 0.2681 0.3341
Brugia malayi Bromodomain containing protein 0.0066 0.0958 0.1319
Mycobacterium leprae Probable lipase LipE 0.0091 0.1391 0.9302
Schistosoma mansoni loxhd1 0.0014 0.0037 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0079 0.1188 0.1477
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.071 0.0978
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0257 0.0579
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0037 0.0439 0.0544
Loa Loa (eye worm) hypothetical protein 0.0149 0.2423 0.3333
Trichomonas vaginalis D-aminoacylase, putative 0.0091 0.1391 0.1931
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0079 0.1188 0.1631
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0094 0.0124
Mycobacterium ulcerans esterase/lipase LipP 0.0091 0.1391 0.4458
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0419 0.7186 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0149 0.2423 0.3336
Trichomonas vaginalis esterase, putative 0.0091 0.1391 0.1931
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0289 0.0392
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0071 0.0278
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0071 0.0084
Echinococcus multilocularis aurora kinase A 0.0042 0.0534 0.0661
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0026 0.0257 0.0352
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0872 0.1083
Schistosoma mansoni inositol monophosphatase 0.0028 0.0282 0.0347
Mycobacterium ulcerans glutaminase 0.0188 0.3106 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0149 0.2423 0.3019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0068 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0068 0.0093
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0068 0.008
Toxoplasma gondii t-complex protein beta subunit 0.0037 0.0439 0.0606
Brugia malayi CXXC zinc finger family protein 0.0028 0.0289 0.0397
Echinococcus granulosus geminin 0.0288 0.4878 0.6083
Loa Loa (eye worm) cytochrome P450 0.0012 0.0011 0.0009
Loa Loa (eye worm) acetyltransferase 0.0101 0.1581 0.2173
Schistosoma mansoni hypothetical protein 0.0028 0.0284 0.035
Echinococcus granulosus GPCR family 2 0.0052 0.071 0.0881
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.07 0.2226
Loa Loa (eye worm) hypothetical protein 0.0036 0.043 0.0587
Mycobacterium ulcerans beta-lactamase 0.0091 0.1391 0.4458
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0068 0.0043
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0068 0.008
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0234 0.095
Brugia malayi RNA binding protein 0.0164 0.2681 0.3691
Trichomonas vaginalis inositol monophosphatase, putative 0.0028 0.0282 0.0387
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0039 0.0489 0.0632
Loa Loa (eye worm) hypothetical protein 0.0149 0.2423 0.3333
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0068 0.0093
Onchocerca volvulus 0.0091 0.1391 0.1894
Loa Loa (eye worm) AUR protein kinase 0.0042 0.0534 0.073
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0149 0.2423 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0197 0.3276 1
Brugia malayi Cell death protein 3 precursor 0.004 0.0495 0.0681
Echinococcus multilocularis fetal alzheimer antigen, falz 0.002 0.015 0.0182
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0234 0.0322
Echinococcus granulosus aurora kinase A 0.0042 0.0534 0.0661
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0068 0.008
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0149 0.2423 1
Schistosoma mansoni cellular tumor antigen P53 0.0023 0.0196 0.0239
Echinococcus multilocularis microtubule associated protein 2 0.0466 0.8015 1
Trichomonas vaginalis glutaminase, putative 0.0188 0.3106 0.432
Entamoeba histolytica protein kinase, putative 0.0042 0.0534 0.1444
Schistosoma mansoni sex comb on midleg homolog 0.0039 0.0489 0.0605
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0039 0.0477 0.059
Giardia lamblia Kinesin-5 0.0058 0.0818 0.2332
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0071 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0068 0.008
Mycobacterium tuberculosis Probable hydrolase 0.0091 0.1391 0.1381
Schistosoma mansoni hypothetical protein 0.0419 0.7186 0.8965
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0803 0.0998
Chlamydia trachomatis DNA topoisomerase I 0.0419 0.7186 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0343 0.0472
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0068 0.008
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.002 0.015 0.0182
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.2691 0.3706
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0088
Echinococcus granulosus beta LACTamase domain containing family member 0.0091 0.1391 0.1731
Schistosoma mansoni hypothetical protein 0.0288 0.4878 0.6083
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0071 0.0278
Plasmodium vivax hypothetical protein, conserved 0.0419 0.7186 1
Echinococcus multilocularis ring and YY1 binding protein 0.0149 0.2423 0.3019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0068 0.008
Trichomonas vaginalis set domain proteins, putative 0.0338 0.5762 0.8017
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0015
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0234 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0068 0.0093
Schistosoma mansoni cpg binding protein 0.0028 0.0289 0.0355
Trypanosoma brucei unspecified product 0.0016 0.0071 0.0278
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0012 0.0011 0.0028
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0071 0.0098
Onchocerca volvulus 0.0091 0.1391 0.1894
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0037 0.0439 0.0606
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0149 0.2423 1
Leishmania major protein kinase, putative 0.0042 0.0534 0.2191
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.2423 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0025 0.0234 0.0287
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0149 0.2423 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.071 0.0881
Loa Loa (eye worm) hypothetical protein 0.0091 0.1391 0.1911
Schistosoma mansoni microtubule-associated protein tau 0.0466 0.8015 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0149 0.2423 1
Onchocerca volvulus 0.0149 0.2423 0.3338
Onchocerca volvulus 0.0149 0.2423 0.3338
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0068 0.0093
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0419 0.7186 0.8965
Echinococcus multilocularis SAM and MBT domain containing protein 0.0039 0.0489 0.0605
Trypanosoma cruzi WLM domain containing protein, putative 0.0149 0.2423 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0068 0.0088
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0037 0.0439 0.1149
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0534 0.0738
Toxoplasma gondii aurora kinase 0.0042 0.0534 0.0738
Onchocerca volvulus 0.0028 0.0284 0.0346
Schistosoma mansoni hypothetical protein 0.0052 0.071 0.0881
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0042 0.0534 0.1444
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0011 0.0009
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0071 0.0195
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0083 0.1251 0.1557
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0071 0.0278
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0534 0.0738
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0037 0.0439 0.0544
Brugia malayi Glycosyl hydrolases family 31 protein 0.0118 0.1882 0.2591
Schistosoma mansoni cytochrome P450 0.0012 0.0011 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0257 0.0352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0197 0.3276 0.4555
Echinococcus granulosus tar DNA binding protein 0.0164 0.2681 0.3341
Schistosoma mansoni hypothetical protein 0.0052 0.071 0.0881
Giardia lamblia Aurora kinase 0.0042 0.0534 0.1444
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0037 0.0439 0.0544
Echinococcus granulosus neutral alpha glucosidase AB 0.0026 0.0257 0.0315
Echinococcus multilocularis zinc finger protein 0.002 0.015 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0068 0.0093
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0149 0.2423 0.3336
Echinococcus multilocularis RUN 0.0014 0.0037 0.0041
Echinococcus multilocularis cpg binding protein 0.0031 0.0345 0.0425
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0068 0.0043
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0068 0.0093
Plasmodium falciparum T-complex protein 1 subunit beta 0.0037 0.0439 0.0606
Brugia malayi brahma associated protein 60 kDa 0.0419 0.7186 0.9895
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0149 0.2423 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0068 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Echinococcus multilocularis lipoxygenase domain containing protein 0.0014 0.0037 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0486 0.0664
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0091 0.1391 0.1381
Mycobacterium tuberculosis Probable esterase LipL 0.0091 0.1391 0.1381
Loa Loa (eye worm) glutaminase 2 0.0188 0.3106 0.4274
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0477 0.1505
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.2423 1
Echinococcus granulosus zinc finger protein Ran binding 0.0149 0.2423 0.3019
Brugia malayi RNA recognition motif domain containing protein 0.0164 0.2681 0.3691
Schistosoma mansoni lipoxygenase 0.0083 0.1251 0.1557
Brugia malayi T-complex protein 1, beta subunit 0.0037 0.0439 0.0605
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0257 0.0352
Schistosoma mansoni zinc finger protein 0.0149 0.2423 0.3019
Schistosoma mansoni hypothetical protein 0.0052 0.071 0.0881
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0071 0.0278
Brugia malayi Cytochrome P450 family protein 0.0012 0.0011 0.0015
Echinococcus granulosus tumor protein p63 0.0156 0.2543 0.3169
Echinococcus multilocularis caspase 2 0.004 0.0495 0.0613
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0011 0.0028
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0039 0.0477 0.1954
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0071 0.0094
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0045 0.0585 0.0725
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0234 0.095
Brugia malayi T-complex protein 1, beta subunit 0.0037 0.0439 0.0605
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0011 0.0009
Echinococcus multilocularis ubiquitin specific protease 41 0.0025 0.0234 0.0287
Leishmania major hypothetical protein, conserved 0.0149 0.2423 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0419 0.7186 1
Schistosoma mansoni hypothetical protein 0.0112 0.1774 0.221
Onchocerca volvulus 0.0039 0.0489 0.0632
Loa Loa (eye worm) doublecortin family protein 0.0014 0.0037 0.0045
Leishmania major hypothetical protein, conserved 0.0149 0.2423 1
Brugia malayi serine/threonine protein kinase 6 0.0042 0.0534 0.0735
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0009
Brugia malayi Cytochrome P450 family protein 0.0012 0.0011 0.0015
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0031 0.0343 0.0472
Plasmodium vivax kinesin-5 0.0058 0.0818 0.1134
Loa Loa (eye worm) brahma associated protein 0.0419 0.7186 0.9895
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.071 0.0881
Echinococcus granulosus lipoxygenase domain containing protein 0.0014 0.0037 0.0041
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0042 0.0534 0.0661
Echinococcus granulosus polycomb protein SCMH1 0.0039 0.0489 0.0605
Schistosoma mansoni sex comb on midleg homolog 0.0039 0.0489 0.0605
Brugia malayi mbt repeat family protein 0.0039 0.0489 0.0673
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0026 0.0257 0.0348
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0068 0.008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0282 0.0387
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0039 0.0477 0.059
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0234 0.095
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0096 0.1494 0.4792
Leishmania major hypothetical protein, conserved 0.0149 0.2423 1
Echinococcus granulosus fetal alzheimer antigen falz 0.002 0.015 0.0182
Echinococcus granulosus Polycystic kidney disease protein 0.0014 0.0037 0.0041
Echinococcus granulosus ring and YY1 binding protein 0.0149 0.2423 0.3019
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0068 0.008
Brugia malayi TAR-binding protein 0.0164 0.2681 0.3691
Leishmania major T-complex protein 1, beta subunit, putative 0.0037 0.0439 0.18
Echinococcus granulosus cpg binding protein 0.0031 0.0345 0.0425
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0011 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0068 0.008
Schistosoma mansoni tar DNA-binding protein 0.0164 0.2681 0.3341
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0197 0.3276 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0803 0.0998
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0039 0.0477 0.0466
Schistosoma mansoni zinc finger protein 0.0013 0.0016 0.0015
Echinococcus multilocularis GPCR, family 2 0.0052 0.071 0.0881
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0068 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0257 0.0352
Echinococcus granulosus SAM and MBT domain containing protein 0.0039 0.0489 0.0605
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.071 0.0881
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.07 0.0869
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0278
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0043 0.0555 0.0688
Onchocerca volvulus Cell death protein 3 homolog 0.004 0.0495 0.0641
Trypanosoma cruzi ISWI complex protein 0.0013 0.0016 0.005
Brugia malayi cytochrome P450 0.0012 0.0011 0.0015
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.0042 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0234 0.032
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0031 0.0343 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0068 0.0093
Leishmania major alpha glucosidase II subunit, putative 0.0026 0.0257 0.1044
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0068 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.7186 1
Brugia malayi glutaminase DH11.1 0.0188 0.3106 0.4277
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0037 0.0439 0.18
Plasmodium falciparum LCCL domain-containing protein 0.0014 0.0037 0.0046
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0419 0.7186 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0051 0.07 0.069
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0011 0.0009
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0028 0.0282 0.0876
Schistosoma mansoni glutaminase 0.0188 0.3106 0.3872
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0282 0.1149
Echinococcus multilocularis dna polymerase eta 0.0016 0.0071 0.0084
Plasmodium falciparum kinesin-5 0.0058 0.0818 0.1134
Leishmania major cytochrome p450-like protein 0.0012 0.0011 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0079 0.1188 0.1477
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0093
Echinococcus multilocularis SWI:SNF matrix associated 0.0419 0.7186 0.8965
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0068 0.008
Brugia malayi Kinesin motor domain containing protein 0.0058 0.0818 0.1127
Schistosoma mansoni hypothetical protein 0.0149 0.2423 0.3019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0068 0.008
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0028 0.0282 0.0658
Schistosoma mansoni hypothetical protein 0.0389 0.6659 0.8308
Brugia malayi nuclear hormone receptor 0.0016 0.0068 0.0093
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0257 0.0352
Echinococcus multilocularis tumor protein p63 0.0156 0.2543 0.3169
Loa Loa (eye worm) RNA binding protein 0.0164 0.2681 0.3687
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0091 0.1391 0.1731
Brugia malayi acetyltransferase, GNAT family protein 0.0101 0.1581 0.2177
Trypanosoma brucei hypothetical protein, conserved 0.0149 0.2423 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0096 0.1494 0.1485
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0068 0.008
Echinococcus granulosus histone acetyltransferase MYST2 0.0045 0.0585 0.0725
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0555 0.0688
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0149 0.2423 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0097 0.1497 0.1864
Onchocerca volvulus 0.0091 0.1391 0.1894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0045
Trypanosoma cruzi ISWI complex protein 0.0013 0.0016 0.005
Trypanosoma cruzi aurora B kinase, putative 0.0042 0.0534 0.2191
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0071 0.0278
Brugia malayi Pre-SET motif family protein 0.0043 0.0555 0.0764
Entamoeba histolytica protein kinase domain containing protein 0.0042 0.0534 0.1444
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0419 0.7186 0.9895
Brugia malayi MH2 domain containing protein 0.0099 0.1534 0.2112
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0149 0.2423 0.3368
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0088
Onchocerca volvulus 0.0149 0.2423 0.3338
Echinococcus granulosus RUN 0.0014 0.0037 0.0041
Echinococcus granulosus ubiquitin specific protease 41 0.0025 0.0234 0.0287
Leishmania major cytochrome p450-like protein 0.0012 0.0011 0.0028
Loa Loa (eye worm) hypothetical protein 0.0091 0.1391 0.1911
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0068 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0079 0.1188 0.1477
Echinococcus granulosus dna polymerase eta 0.0016 0.0071 0.0084
Onchocerca volvulus 0.0028 0.0289 0.0352
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0257 0.0579
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0037 0.0439 0.0544
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0071 0.0195

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.077 uM In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B) ChEMBL. 10753467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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