Detailed information for compound 1032274

Basic information

Technical information
  • TDR Targets ID: 1032274
  • Name: 3,4-dimethoxy-N-[(4-methoxyphenyl)methylidene amino]benzamide
  • MW: 314.336 | Formula: C17H18N2O4
  • H donors: 1 H acceptors: 1 LogP: 2.75 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=N/NC(=O)c1ccc(c(c1)OC)OC
  • InChi: 1S/C17H18N2O4/c1-21-14-7-4-12(5-8-14)11-18-19-17(20)13-6-9-15(22-2)16(10-13)23-3/h4-11H,1-3H3,(H,19,20)/b18-11+
  • InChiKey: DNWKVLCZFUKHCS-WOJGMQOQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dimethoxy-N-[(4-methoxyphenyl)methyleneamino]benzamide
  • 3,4-dimethoxy-N-[(4-methoxybenzylidene)amino]benzamide
  • BAS 00125496
  • 3,4-Dimethoxy-benzoic acid (4-methoxy-benzylidene)-hydrazide
  • ST5299056

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0061 0.0194 0.0458
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0095 0.0228
Schistosoma mansoni hypothetical protein 0.0097 0.0328 0.0859
Schistosoma mansoni hypothetical protein 0.0067 0.0217 0.056
Entamoeba histolytica hypothetical protein 0.003 0.0081 0.1009
Loa Loa (eye worm) hypothetical protein 0.0081 0.0269 0.0738
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0098 0.0285
Trichomonas vaginalis inositol monophosphatase, putative 0.0027 0.0069 0.0158
Schistosoma mansoni kinase 0.009 0.0302 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0074
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0098 0.1565
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0067 0.0217 0.0217
Brugia malayi beta-lactamase family protein 0.0035 0.0098 0.0268
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.006 0.006
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0056 0.0126
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0035 0.01 0.0275
Brugia malayi PHD-finger family protein 0.0011 0.0011 0.0029
Schistosoma mansoni Smad4 0.0018 0.0034 0.0063
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0041 0.0119 0.1777
Brugia malayi Hypothetical C28H8.9 in chromosome III 0.0011 0.0011 0.0029
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0095 0.1547
Trypanosoma brucei protein kinase, putative 0.0035 0.01 0.1607
Trichomonas vaginalis CAMK family protein kinase 0.0177 0.0623 0.1492
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0024 0.0058 0.0924
Schistosoma mansoni ran 0.0041 0.0119 0.0294
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0122 0.0285
Loa Loa (eye worm) hypothetical protein 0.0073 0.024 0.0658
Trichomonas vaginalis ran, putative 0.0041 0.0119 0.0278
Entamoeba histolytica hypothetical protein 0.0067 0.0217 0.3275
Brugia malayi MH1 domain containing protein 0.0018 0.0034 0.0092
Brugia malayi intermediate filament protein 0.0038 0.0111 0.0303
Loa Loa (eye worm) inositol-1 0.0027 0.0069 0.019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.0792 0.2636
Echinococcus granulosus Zinc finger DBF type 0.0011 0.0011 0.0032
Onchocerca volvulus Huntingtin homolog 0.018 0.0637 0.1512
Echinococcus granulosus lysine specific demethylase 5B 0.0011 0.0011 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.006 0.0134
Echinococcus multilocularis transcription factor Dp 1 0.0054 0.017 0.017
Loa Loa (eye worm) importin-beta domain-containing protein 0.0014 0.0021 0.0058
Loa Loa (eye worm) hypothetical protein 0.0157 0.0551 0.1511
Echinococcus multilocularis mitogen activated protein kinase 3 0.0035 0.01 0.01
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0391 0.1418 0.1418
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0218 0.0777 0.0777
Loa Loa (eye worm) hypothetical protein 0.0146 0.0509 0.1396
Schistosoma mansoni hypothetical protein 0.0177 0.0624 0.1659
Onchocerca volvulus 0.0018 0.0036 0.0062
Schistosoma mansoni hypothetical protein 0.0365 0.1323 0.3551
Echinococcus multilocularis troponin i 0.0073 0.024 0.024
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0165 0.0582 0.1379
Trichomonas vaginalis CAMK family protein kinase 0.0177 0.0623 0.1492
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0085 0.0284 0.074
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0095 0.1547
Schistosoma mansoni tsg101-related 0.0151 0.0527 0.1397
Echinococcus granulosus histone acetyltransferase myst3 0.0011 0.0011 0.0032
Schistosoma mansoni ferritin light chain 0.0012 0.0013 0.0007
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0098 0.0268
Toxoplasma gondii HEAT repeat-containing protein 0.0014 0.0021 0.0238
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0097 0.0328 0.09
Schistosoma mansoni smad1 5 8 and 0.0018 0.0034 0.0063
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0041 0.0119 0.1982
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0129 0.0445 0.0445
Entamoeba histolytica hypothetical protein 0.003 0.0081 0.1009
Brugia malayi cytoplasmic intermediate filament protein 0.0021 0.0045 0.0123
Echinococcus granulosus histone acetyltransferase myst4 0.0011 0.0011 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0601 0.2194 0.6019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0098 0.0268
Loa Loa (eye worm) kap beta 3 protein 0.0014 0.0021 0.0058
Echinococcus multilocularis musashi 0.0038 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0098 0.0268
Echinococcus multilocularis mitogen activated protein kinase 0.0035 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0013
Brugia malayi kap beta 3 protein 0.0014 0.0021 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0098 0.0225
Echinococcus multilocularis Zinc finger, DBF type 0.0011 0.0011 0.0011
Trichomonas vaginalis hypothetical protein 0.0014 0.0021 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0087 0.02
Trypanosoma cruzi polo-like protein kinase, putative 0.0177 0.0623 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0035 0.01 0.1607
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0095 0.0276
Loa Loa (eye worm) CXXC zinc finger family protein 0.0078 0.026 0.0712
Entamoeba histolytica hypothetical protein 0.0067 0.0217 0.3275
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0034 0.0034
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0041 0.0119 0.2217
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.002 0.0319
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0092 0.0212
Echinococcus multilocularis microtubule associated protein 2 0.0508 0.1851 0.1851
Schistosoma mansoni rotamase 0.0025 0.006 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Schistosoma mansoni hypothetical protein 0.0097 0.0328 0.0859
Brugia malayi PHD-finger family protein 0.0011 0.0011 0.0029
Schistosoma mansoni hypothetical protein 0.0097 0.0328 0.0859
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0292 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0098 0.0268
Brugia malayi MH2 domain containing protein 0.0018 0.0034 0.0092
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0094 0.0316 0.0867
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0098 0.0268
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0034 0.0063
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0165 0.0582 0.1546
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0095 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0181 0.0428
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0091 0.0305 0.0711
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0123 0.0425 0.6712
Brugia malayi beta-lactamase family protein 0.0035 0.0098 0.0268
Echinococcus granulosus methyl CpG binding domain protein 2 0.0061 0.0195 0.0601
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.002 0.0055
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0098 0.0301
Echinococcus multilocularis lamin dm0 0.0038 0.0111 0.0111
Echinococcus granulosus geminin 0.0365 0.1323 0.4086
Trichomonas vaginalis CMGC family protein kinase 0.0035 0.01 0.0232
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0021 0.0045 0.0123
Echinococcus multilocularis lamin 0.0038 0.0111 0.0111
Plasmodium vivax ataxin-2 like protein, putative 0.0015 0.0025 0.0297
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0064 0.0204 0.056
Echinococcus multilocularis PHD finger protein 14 0.0011 0.0011 0.0011
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0655 0.2396 0.7398
Brugia malayi MH1 domain containing protein 0.0018 0.0034 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0074
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0024 0.0059 0.0154
Plasmodium vivax SET domain containing protein 0.0015 0.0026 0.031
Echinococcus multilocularis Protein lozenge 0.0079 0.0261 0.0261
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0167 0.0589 0.1566
Schistosoma mansoni cpg binding protein 0.0078 0.026 0.0674
Brugia malayi Inositol-1 0.0027 0.0069 0.019
Plasmodium falciparum ataxin-2 like protein, putative 0.0015 0.0025 0.0618
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0144 0.0501 0.8773
Echinococcus granulosus Smad4 0.0018 0.0034 0.0104
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0069 0.096
Brugia malayi Troponin T 0.0043 0.0129 0.0355
Plasmodium falciparum transportin 0.0014 0.0021 0.0452
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0129 0.0445 0.1374
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0056 0.0126
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0095 0.1243
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0081 0.1147
Echinococcus multilocularis chromobox protein 1 0.0145 0.0505 0.0505
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0098 0.0285
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0098 0.1772
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.003 0.0052
Echinococcus multilocularis lysine specific demethylase 5B 0.0011 0.0011 0.0011
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0809 0.2968 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0074
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0041 0.0119 0.0327
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0011 0.0032
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0098 0.0285
Schistosoma mansoni hypothetical protein 0.0074 0.0242 0.0627
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0098 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0056 0.0126
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0098 0.0225
Schistosoma mansoni ferritin 0.0012 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0188 0.0667 0.1829
Plasmodium falciparum importin beta, putative 0.0075 0.0247 1
Leishmania major hypothetical protein, conserved 0.0055 0.0171 0.2513
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.002 0.0397
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0058 0.0183 0.2817
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Plasmodium falciparum zinc finger protein, putative 0.0016 0.0028 0.0751
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0133 0.0461 0.1087
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Echinococcus granulosus inositol monophosphatase 1 0.0027 0.0069 0.0214
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0307 0.1105 0.3031
Onchocerca volvulus 0.0038 0.0111 0.0242
Entamoeba histolytica hypothetical protein 0.0024 0.0056 0.0605
Loa Loa (eye worm) hypothetical protein 0.0137 0.0477 0.1309
Schistosoma mansoni hypothetical protein 0.0132 0.0457 0.1208
Trypanosoma cruzi ISWI complex protein 0.0055 0.0171 0.2627
Brugia malayi RNA, U transporter 1 0.0213 0.0759 0.2083
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0069 0.1113
Schistosoma mansoni ferritin 0.0012 0.0013 0.0007
Leishmania major hypothetical protein, conserved 0.0035 0.0098 0.1287
Brugia malayi PHD-finger family protein 0.0011 0.0011 0.0029
Schistosoma mansoni zinc finger protein 0.0055 0.0171 0.0435
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0067 0.0217 0.0671
Loa Loa (eye worm) hypothetical protein 0.0629 0.2301 0.6312
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0188 0.0667 0.2059
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0069 0.082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0144 0.0501 0.1328
Trichomonas vaginalis helicase, putative 0.0018 0.0035 0.0074
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0014 0.0021 0.034
Echinococcus multilocularis phd finger protein 10 0.0011 0.0011 0.0011
Onchocerca volvulus Huntingtin homolog 0.018 0.0637 0.1512
Loa Loa (eye worm) bromodomain containing protein 0.0063 0.0203 0.0556
Schistosoma mansoni tsg101-related 0.0123 0.0425 0.1121
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0155
Loa Loa (eye worm) histone methyltransferase 0.003 0.0078 0.0214
Echinococcus granulosus Chromo domain 0.0024 0.0056 0.0174
Brugia malayi Heterochromatin protein 1 0.0145 0.0505 0.1385
Echinococcus granulosus uro adherence factor A 0.0011 0.0011 0.0032
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0011 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0155
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0097 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0205 0.0728 0.1996
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0035 0.01 0.1463
Loa Loa (eye worm) hypothetical protein 0.021 0.0745 0.2045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0218 0.0777 0.2399
Toxoplasma gondii AP2 domain transcription factor AP2VIIa-7 0.0011 0.0011 0.0048
Trichomonas vaginalis hypothetical protein 0.0088 0.0295 0.0702
Echinococcus multilocularis polycomb protein SCMH1 0.0165 0.0582 0.0582
Echinococcus multilocularis transportin 1 0.0014 0.0021 0.0021
Loa Loa (eye worm) PHD-finger family protein 0.0011 0.0011 0.0029
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0011 0.0011
Echinococcus multilocularis kelch ECH associated protein 1 0.0176 0.0622 0.0622
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0038 0.0111 0.0303
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0155
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0014 0.002 0.0153
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0144 0.0501 0.0501
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0177 0.0623 1
Schistosoma mansoni troponin I 0.0073 0.024 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0056 0.0126
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0056 0.0056
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0035 0.0098 0.0237
Echinococcus multilocularis dnaJ subfamily B 0.0882 0.3238 0.3238
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0056 0.0126
Schistosoma mansoni intermediate filament proteins 0.0038 0.0111 0.0271
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0094 0.0316 0.0977
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0122 0.0285
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.002 0.0061
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.002 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0056 0.1941
Loa Loa (eye worm) MBCTL1 0.0188 0.0667 0.1829
Echinococcus granulosus GTP binding nuclear protein Ran 0.0041 0.0119 0.0369
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0024 0.0059 0.0154
Echinococcus multilocularis importin 5 0.0014 0.0021 0.0021
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0011 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0293 0.0697
Brugia malayi chromobox protein homolog 3 0.0081 0.0269 0.0738
Onchocerca volvulus Serine\/threonine kinase homolog 0.0177 0.0623 0.1479
Schistosoma mansoni lozenge 0.0079 0.0261 0.0678
Echinococcus granulosus TAF3 RNA polymerase II TATA box binding protein 0.0011 0.0011 0.0032
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.006 0.0186
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0035 0.01 0.1463
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0027 0.0069 0.019
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0027 0.0069 0.1093
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0095 0.1523
Schistosoma mansoni inositol monophosphatase 0.0027 0.0069 0.0159
Mycobacterium leprae Probable lipase LipE 0.0035 0.0098 0.0285
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0056 0.0126
Toxoplasma gondii LsmAD domain-containing protein 0.0015 0.0025 0.0307
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0056 0.1941
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0132 0.0457 0.1254
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0809 0.2968 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0098 0.0098
Brugia malayi SET domain containing protein 0.0031 0.0082 0.0225
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0188 0.0667 0.1829
Schistosoma mansoni troponin I 0.0073 0.024 0.062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0122 0.0285
Schistosoma mansoni hypothetical protein 0.0055 0.0171 0.0435
Schistosoma mansoni hypothetical protein 0.0365 0.1323 0.3551
Brugia malayi Troponin T 0.0043 0.0129 0.0355
Brugia malayi MH2 domain containing protein 0.0257 0.0923 0.2532
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0205 0.0728 0.194
Toxoplasma gondii HEAT repeat-containing protein 0.0014 0.0021 0.0238
Loa Loa (eye worm) troponin 0.0043 0.0129 0.0355
Loa Loa (eye worm) runx1 0.0079 0.0261 0.0717
Schistosoma mansoni hypothetical protein 0.1009 0.3707 1
Echinococcus granulosus microtubule associated protein 2 0.0508 0.1851 0.5715
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0025 0.006 0.0164
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0056 0.0155
Trichomonas vaginalis rotamase, putative 0.0025 0.006 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0115
Brugia malayi Smad1 0.0018 0.0034 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0081 0.0185
Entamoeba histolytica serine/threonine protein kinase, putative 0.0177 0.0623 1
Schistosoma mansoni hypothetical protein 0.0024 0.0056 0.0124
Leishmania major hypothetical protein, conserved 0.0015 0.0025 0.0086
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0095 0.1377
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0177 0.0623 0.1709
Loa Loa (eye worm) hypothetical protein 0.0075 0.0247 0.0677
Giardia lamblia Kinase, CMGC MAPK 0.0035 0.01 0.133
Echinococcus granulosus intermediate filament protein 0.0038 0.0111 0.0342
Brugia malayi PHD-finger family protein 0.0011 0.0011 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0317 0.1143 0.1143
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0056 0.0863
Schistosoma mansoni ferritin 0.0012 0.0013 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0177 0.0623 0.1492
Loa Loa (eye worm) beta-lactamase 0.0035 0.0098 0.0268
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0078 0.0078
Trypanosoma cruzi ISWI complex protein 0.0055 0.0171 0.2627
Echinococcus multilocularis PHD and RING finger domain containing protein 1 0.0011 0.0011 0.0011
Entamoeba histolytica Ran family GTPase 0.0041 0.0119 0.1649
Echinococcus granulosus chromobox protein 1 0.0145 0.0505 0.1559
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0056 0.0124
Plasmodium falciparum ataxin-2 like protein, putative 0.0015 0.0025 0.0618
Trichomonas vaginalis rotamase, putative 0.0024 0.0058 0.0129
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0098 0.0285
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0024 0.0058 0.0768
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0296
Echinococcus granulosus transportin 1 0.0014 0.0021 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0292 0.0694
Echinococcus granulosus kelch ECH associated protein 1 like 0.0176 0.0622 0.192
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0122 0.0285
Echinococcus granulosus kelch ECH associated protein 1 like 0.0176 0.0622 0.192
Loa Loa (eye worm) heterochromatin protein 1 0.0145 0.0505 0.1385
Schistosoma mansoni methyl-cpg binding protein mbd 0.0061 0.0195 0.0498
Entamoeba histolytica hypothetical protein 0.0024 0.0056 0.0605
Schistosoma mansoni troponin I 0.0073 0.024 0.062
Leishmania major importin beta-1 subunit, putative 0.0061 0.0194 0.2888
Echinococcus multilocularis remodeling and spacing factor 1 0.0011 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0056 0.0111
Schistosoma mansoni chromobox protein 0.0145 0.0505 0.1337
Echinococcus multilocularis ferritin 0.0012 0.0013 0.0013
Brugia malayi hypothetical protein 0.0015 0.0025 0.0069
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0081 0.0269 0.0624
Loa Loa (eye worm) MH2 domain-containing protein 0.0257 0.0923 0.2532
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0095
Brugia malayi Latrophilin receptor protein 2 0.0097 0.0328 0.09
Echinococcus granulosus importin subunit beta 1 0.0075 0.0247 0.0762
Echinococcus granulosus chromobox protein 1 0.0145 0.0505 0.1559
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0024 0.0058 0.0624
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0293 0.0697
Toxoplasma gondii histone lysine methyltransferase SET1 0.0162 0.057 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0098 0.0268
Toxoplasma gondii exonuclease III APE 0.0014 0.002 0.0214
Brugia malayi MH1 domain containing protein 0.001 0.0005 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0095 0.0095
Echinococcus multilocularis importin subunit beta 1 0.0075 0.0247 0.0247
Echinococcus multilocularis Smad4 0.0018 0.0034 0.0034
Echinococcus granulosus smad 0.0018 0.0034 0.0104
Schistosoma mansoni troponin t invertebrate 0.0091 0.0305 0.0797
Echinococcus multilocularis cpg binding protein 0.009 0.0301 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0074
Echinococcus multilocularis phd finger protein 12 0.0011 0.0011 0.0011
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0102 0.028
Schistosoma mansoni inositol monophosphatase 0.0027 0.0069 0.0159
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0155
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0655 0.2396 0.2396
Mycobacterium ulcerans lipase LipD 0.0035 0.0098 0.0285
Onchocerca volvulus 0.0035 0.0098 0.021
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0095 0.1523
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0177 0.0623 0.1924
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0094 0.0316 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0269 0.0639
Schistosoma mansoni chromobox protein 0.0024 0.0056 0.0124
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Toxoplasma gondii peptidylprolyl isomerase 0.0024 0.0058 0.0884
Schistosoma mansoni ferritin 0.0012 0.0013 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0035 0.01 0.1463
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Brugia malayi CHD4 protein 0.0035 0.0098 0.027
Echinococcus multilocularis expressed protein 0.0012 0.0013 0.0013
Brugia malayi Pre-SET motif family protein 0.0144 0.0501 0.1375
Echinococcus granulosus expressed protein 0.0025 0.006 0.0184
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0188 0.0667 0.0667
Brugia malayi hypothetical protein 0.0067 0.0217 0.0596
Trypanosoma cruzi PAB1-binding protein , putative 0.0015 0.0025 0.0238
Trichomonas vaginalis inhibitor of growth, putative 0.0011 0.0011 0.0016
Echinococcus granulosus troponin i 0.0073 0.024 0.074
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0035 0.0098 0.0303
Echinococcus multilocularis zinc finger protein 0.0075 0.0245 0.0245
Schistosoma mansoni transcription factor LCR-F1 0.0067 0.0217 0.056
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0623 0.1657
Echinococcus granulosus survival motor neuron protein 1 0.0646 0.2364 0.73
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0094 0.0316 0.4991
Toxoplasma gondii ABC1 family protein 0.0035 0.0098 0.1594
Echinococcus multilocularis expressed protein 0.0025 0.006 0.006
Schistosoma mansoni cpg binding protein 0.009 0.0301 0.0787
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1296
Onchocerca volvulus 0.0024 0.0056 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0056 0.0126
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0094 0.0316 0.0867
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Schistosoma mansoni myst-related protein 0.0016 0.0028 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0095 0.0095
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0025 0.006 0.0164
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0056 0.0155
Loa Loa (eye worm) hypothetical protein 0.0073 0.024 0.0658
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.006 0.006
Echinococcus granulosus remodeling and spacing factor 1 0.0011 0.0011 0.0032
Schistosoma mansoni lamin 0.0038 0.0111 0.0271
Echinococcus granulosus polycomb protein SCMH1 0.0165 0.0582 0.1797
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0303
Loa Loa (eye worm) PHD-finger family protein 0.0011 0.0011 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.002 0.0038
Trichomonas vaginalis chromobox protein, putative 0.0145 0.0505 0.1207
Entamoeba histolytica hypothetical protein 0.0024 0.0056 0.0605
Plasmodium vivax transportin, putative 0.0014 0.0021 0.0217
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0058 0.0183 0.2938
Echinococcus granulosus kelch ECH associated protein 1 0.0176 0.0622 0.192
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0034 0.0092
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0094 0.0316 0.0827
Giardia lamblia Kinase, PLK 0.0177 0.0623 1
Brugia malayi Bromodomain associated family protein 0.0011 0.0011 0.0029
Echinococcus multilocularis GPCR, family 2 0.0097 0.0328 0.0328
Schistosoma mansoni cpg binding protein 0.009 0.0301 0.0787
Schistosoma mansoni SET domain protein 0.0018 0.0036 0.007
Loa Loa (eye worm) nuclear factor I 0.001 0.0005 0.0013
Echinococcus granulosus oncosphere protein Tso22e 0.0091 0.0305 0.0942
Leishmania major GTP-binding protein, putative 0.0041 0.0119 0.1649
Treponema pallidum exodeoxyribonuclease (exoA) 0.0014 0.002 1
Loa Loa (eye worm) troponin I 0.0073 0.024 0.0658
Brugia malayi Troponin I 0.0073 0.024 0.0658
Brugia malayi mbt repeat family protein 0.0165 0.0582 0.1596
Brugia malayi Intermediate filament tail domain containing protein 0.0038 0.0111 0.0303
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0098 0.0225
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0085 0.0284 0.0284
Echinococcus granulosus neuropeptide s receptor 0.0317 0.1143 0.3529
Trichomonas vaginalis CAMK family protein kinase 0.0177 0.0623 0.1492
Trichomonas vaginalis CAMK family protein kinase 0.0177 0.0623 0.1492
Loa Loa (eye worm) hypothetical protein 0.0133 0.0461 0.1264
Toxoplasma gondii SWI2/SNF2-containing PHD finger protein 0.0011 0.0011 0.0048
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0094 0.0316 0.4913
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Trichomonas vaginalis importin beta-1, putative 0.0061 0.0194 0.0458
Onchocerca volvulus 0.0165 0.0582 0.1379
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0041 0.0119 0.1649
Mycobacterium tuberculosis Conserved protein 0.0035 0.0098 0.0285
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0181 0.0639 0.0639
Trypanosoma brucei ISWI complex protein 0.0055 0.0171 0.2752
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0098 0.0285
Schistosoma mansoni hypothetical protein 0.0801 0.2937 0.7917
Echinococcus multilocularis survival motor neuron protein 1 0.0646 0.2364 0.2364
Brugia malayi serine/threonine-protein kinase plk-2 0.0177 0.0623 0.1709
Brugia malayi hypothetical protein 0.0181 0.0639 0.1753
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0122 0.0285
Loa Loa (eye worm) intermediate filament protein 0.0038 0.0111 0.0303
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0024 0.0058 0.0624
Loa Loa (eye worm) latrophilin receptor protein 2 0.0097 0.0328 0.09
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0056 0.1941
Schistosoma mansoni hypothetical protein 0.0097 0.0328 0.0859
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0056 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0098 0.142
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0098 0.0225
Trypanosoma brucei Ring finger domain/PHD-finger, putative 0.0011 0.0011 0.0169
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0095 0.1719
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0056 0.0605
Loa Loa (eye worm) hypothetical protein 0.0097 0.0328 0.09
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0095
Brugia malayi latrophilin 2 splice variant baaae 0.021 0.0745 0.2045
Brugia malayi Bromodomain containing protein 0.0137 0.0476 0.1307
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0205 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0056 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0056 0.0126
Plasmodium vivax SET domain protein, putative 0.0144 0.0501 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0014 0.002 0.0022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0801 0.2937 0.8056
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0056 0.0155
Loa Loa (eye worm) Smad1 0.0018 0.0034 0.0092
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0098 0.0285
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Schistosoma mansoni troponin I 0.0073 0.024 0.062
Echinococcus granulosus mitogen activated protein kinase 3 0.0035 0.01 0.0309
Trichomonas vaginalis ferritin, putative 0.0012 0.0013 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0056 0.0934
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.006 0.0135
Echinococcus granulosus lysine specific demethylase 5A 0.0011 0.0011 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0992 0.3646 1
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0081 0.1147
Brugia malayi hypothetical protein 0.018 0.0637 0.1747
Schistosoma mansoni methyl-cpg binding protein mbd 0.0061 0.0195 0.0498
Trypanosoma brucei PAB1-binding protein , putative 0.0015 0.0025 0.0403
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0098 0.0225
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0035 0.01 0.164
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0081 0.0185
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0056 0.0605
Echinococcus granulosus lamin dm0 0.0038 0.0111 0.0342
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0018 0.0037 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0098 0.142
Echinococcus granulosus histone lysine methyltransferase setb 0.0205 0.0728 0.2247
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0056 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.0035 0.01 0.0232
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0041 0.0119 0.1777
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0177 0.0623 0.0623
Echinococcus granulosus histone acetyltransferase MYST2 0.0188 0.0667 0.2059
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0027 0.0069 1
Schistosoma mansoni sex comb on midleg homolog 0.0165 0.0582 0.1546
Loa Loa (eye worm) hypothetical protein 0.0646 0.2364 0.6484
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0122 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0074
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0011 0.0048
Onchocerca volvulus 0.0629 0.2301 0.553
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0094 0.0316 0.5076
Entamoeba histolytica hypothetical protein 0.003 0.0081 0.1009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0391 0.1418 0.4378
Echinococcus granulosus ferritin 0.0012 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0155
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0095 0.1377
Echinococcus granulosus PHD finger protein 14 0.0011 0.0011 0.0032
Schistosoma mansoni hypothetical protein 0.021 0.0745 0.1988
Trichomonas vaginalis CMGC family protein kinase 0.0035 0.01 0.0232
Trichomonas vaginalis esterase, putative 0.0035 0.0098 0.0225
Brugia malayi mbt repeat family protein 0.0165 0.0582 0.1596
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0069
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.003 0.0081 0.1147
Entamoeba histolytica HEAT repeat domain containing protein 0.0014 0.0021 0.0022
Brugia malayi PHD-finger family protein 0.0011 0.0011 0.0029
Schistosoma mansoni chromobox protein 0.0145 0.0505 0.1337
Schistosoma mansoni hypothetical protein 0.0882 0.3238 0.8732
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0074
Entamoeba histolytica hypothetical protein 0.003 0.0081 0.1009
Brugia malayi Pre-SET motif family protein 0.0992 0.3646 1
Echinococcus granulosus zinc finger protein 0.0075 0.0245 0.0756
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0056 0.0124
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0098 0.0235
Loa Loa (eye worm) helicase 0.0024 0.0056 0.0155
Echinococcus granulosus fetal alzheimer antigen falz 0.0085 0.0284 0.0877
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0011
Loa Loa (eye worm) PHD-finger family protein 0.0074 0.0242 0.0664
Trypanosoma cruzi PAB1-binding protein , putative 0.0015 0.0025 0.0238
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0137 0.0476 0.1469
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0069 0.096
Brugia malayi isocitrate dehydrogenase 0.0034 0.0095 0.026
Trichomonas vaginalis CAMK family protein kinase 0.0177 0.0623 0.1492
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0097 0.0328 0.1013
Onchocerca volvulus 0.0035 0.0098 0.021
Onchocerca volvulus 0.0078 0.026 0.0601
Trypanosoma cruzi importin beta-1 subunit, putative 0.0061 0.0194 0.2997
Loa Loa (eye worm) hypothetical protein 0.0601 0.2194 0.6019
Schistosoma mansoni smad1 5 8 and 0.0018 0.0034 0.0063
Schistosoma mansoni bromodomain containing protein 0.0231 0.0824 0.2201
Brugia malayi MAP kinase sur-1 0.0035 0.01 0.0275
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0014 0.002 0.1184
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0032
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.006 0.0186
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0078 0.0241
Brugia malayi MH2 domain containing protein 0.0018 0.0034 0.0092
Echinococcus multilocularis histone acetyltransferase myst3 0.0011 0.0011 0.0011
Echinococcus multilocularis histone acetyltransferase MYST2 0.0188 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0629 0.2301 0.6312
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0041 0.0119 0.0327
Echinococcus granulosus translational activator gcn1 0.0014 0.0021 0.0065
Loa Loa (eye worm) troponin T 0.0043 0.0129 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0056 0.0126
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0014 0.002 0.0153
Onchocerca volvulus 0.0132 0.0457 0.1078
Echinococcus granulosus importin 5 0.0014 0.0021 0.0065
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0056 0.0174
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0095 0.0095
Schistosoma mansoni ferritin light chain 0.0012 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0056 0.0934
Brugia malayi CXXC zinc finger family protein 0.0078 0.026 0.0712
Echinococcus granulosus chromobox protein 2 0.0024 0.0056 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0056 0.0126
Brugia malayi hypothetical protein 0.0659 0.2413 0.6618
Echinococcus granulosus phd finger protein 10 0.0011 0.0011 0.0032
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0034 0.0104
Echinococcus multilocularis kelch ECH associated protein 1 0.0176 0.0622 0.0622
Echinococcus multilocularis SAM and MBT domain containing protein 0.0165 0.0582 0.0582
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0098 0.0235
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.01 0.0242
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0015 0.0024 0.0393
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0041 0.0119 0.0119
Schistosoma mansoni lamin 0.0038 0.0111 0.0271
Brugia malayi hypothetical protein 0.0011 0.0011 0.0029
Leishmania major hypothetical protein, conserved 0.0058 0.0183 0.2705
Echinococcus granulosus Chromobox protein 3 0.0024 0.0056 0.0174
Onchocerca volvulus 0.0659 0.2413 0.58
Onchocerca volvulus 0.0167 0.0589 0.1397
Entamoeba histolytica hypothetical protein 0.0061 0.0194 0.2888
Brugia malayi Bromodomain containing protein 0.0273 0.098 0.2687
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0027 0.0069 0.082
Echinococcus multilocularis snurportin 1 0.0801 0.2937 0.2937
Echinococcus multilocularis chromobox protein 2 0.0024 0.0056 0.0056
Brugia malayi hypothetical protein 0.0011 0.0011 0.0029
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0095 0.026
Echinococcus granulosus expressed protein 0.0012 0.0013 0.0041
Schistosoma mansoni apoferritin-2 0.0012 0.0013 0.0007
Brugia malayi PHD-finger family protein 0.0094 0.0316 0.0865
Brugia malayi Importin beta-1 subunit 0.0075 0.0247 0.0677
Trichomonas vaginalis CMGC family protein kinase 0.0035 0.01 0.0232
Onchocerca volvulus Troponin I homolog 0.0073 0.024 0.0553
Echinococcus granulosus snurportin 1 0.0801 0.2937 0.907
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0095 0.3573
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0016
Trichomonas vaginalis hypothetical protein 0.0024 0.0056 0.0126
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0041 0.0119 0.1916
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0355
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0061 0.0194 0.0458
Schistosoma mansoni ap endonuclease 0.0014 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0253 0.0906 0.2486
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0098 0.0285
Onchocerca volvulus 0.1129 0.4153 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0014 0.002 0.0022
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0181 0.0639 0.1974
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0056 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0092 0.0212
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0035 0.01 0.1463
Echinococcus granulosus phd finger protein 12 0.0011 0.0011 0.0032
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0035 0.01 0.133
Schistosoma mansoni ap endonuclease 0.0014 0.002 0.0025
Schistosoma mansoni myelin transcription factor 1 myt1 0.0188 0.0667 0.1775
Loa Loa (eye worm) hypothetical protein 0.0035 0.0098 0.0268
Schistosoma mansoni myst-related protein 0.0016 0.0028 0.0048
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0056 0.0126
Entamoeba histolytica hypothetical protein 0.0016 0.0028 0.0139
Schistosoma mansoni tsg101-related 0.0151 0.0527 0.1397
Trypanosoma brucei polo-like protein kinase 0.0177 0.0623 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0165 0.0582 0.1797
Echinococcus multilocularis Kelch repeat type 1 0.0177 0.0624 0.0624
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0095 0.0293
Schistosoma mansoni microtubule-associated protein tau 0.0508 0.1851 0.4978
Brugia malayi SET domain containing protein 0.0018 0.0036 0.0099
Brugia malayi Calcitonin receptor-like protein seb-1 0.0307 0.1105 0.3031
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0098 0.0285
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0155
Trypanosoma brucei importin beta-1 subunit, putative 0.0075 0.0247 0.3959
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.002 0.0038
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0056 0.0056
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0034 0.0092
Brugia malayi beta-lactamase 0.0035 0.0098 0.0268
Mycobacterium ulcerans hypothetical protein 0.0035 0.0098 0.0285
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0043 0.0129 0.0287
Brugia malayi hypothetical protein 0.0043 0.0129 0.0355
Echinococcus multilocularis uro adherence factor A 0.0011 0.0011 0.0011
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0035 0.01 0.133
Echinococcus multilocularis histone acetyltransferase myst4 0.0011 0.0011 0.0011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0098 0.0285
Loa Loa (eye worm) CHromoDomain protein family member 0.0035 0.0098 0.027
Echinococcus multilocularis TAF3 RNA polymerase II, TATA box binding protein 0.0011 0.0011 0.0011
Schistosoma mansoni chromobox protein 0.0024 0.0056 0.0124
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0056 0.0863
Schistosoma mansoni bromodomain containing protein 0.002 0.0042 0.0085
Echinococcus multilocularis Chromo domain 0.0024 0.0056 0.0056
Brugia malayi MH1 domain containing protein 0.001 0.0005 0.0013
Brugia malayi jmjC domain containing protein 0.0011 0.0011 0.0029
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0034 0.0104
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0056 0.0863
Schistosoma mansoni zinc finger protein 0.0075 0.0245 0.0634
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0056 0.0934
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0041 0.0119 0.4609
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0269 0.0639
Echinococcus granulosus dnaJ subfamily B 0.0882 0.3238 1
Plasmodium vivax importin-beta 2, putative 0.0075 0.0247 0.481
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0181 0.0428
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0056 0.0124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Leishmania major hypothetical protein, conserved 0.0014 0.0021 0.0022
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.002 0.002
Brugia malayi hypothetical protein 0.0629 0.2301 0.6312
Echinococcus granulosus lamin 0.0038 0.0111 0.0342
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0056 0.0126
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0069 0.0158
Trichomonas vaginalis chromobox protein, putative 0.0145 0.0505 0.1207
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0011 0.0048
Toxoplasma gondii HEAT repeat-containing protein 0.0075 0.0247 0.4245
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0029
Echinococcus granulosus transcription factor Dp 1 0.0054 0.017 0.0524
Entamoeba histolytica hypothetical protein 0.0067 0.0217 0.3275
Brugia malayi hypothetical protein 0.0024 0.0056 0.0155
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0087 0.0292 0.068
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0061 0.0195 0.0195
Schistosoma mansoni sex comb on midleg homolog 0.0165 0.0582 0.1546
Brugia malayi Troponin T 0.0043 0.0129 0.0355
Schistosoma mansoni smad1 5 8 and 0.0018 0.0034 0.0063
Brugia malayi hypothetical protein 0.0646 0.2364 0.6484
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0024 0.0058 0.0768
Brugia malayi N-terminal motif family protein 0.0133 0.0461 0.1264
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0035 0.0098 0.0098
Brugia malayi hypothetical protein 0.001 0.0005 0.0014
Brugia malayi Troponin family protein 0.0073 0.024 0.0658
Mycobacterium ulcerans beta-lactamase 0.0035 0.0098 0.0285
Onchocerca volvulus 0.0038 0.0111 0.0242
Loa Loa (eye worm) hypothetical protein 0.0035 0.0098 0.0268
Trichomonas vaginalis set domain proteins, putative 0.1129 0.4153 1
Echinococcus multilocularis smad 0.0018 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0155
Loa Loa (eye worm) hypothetical protein 0.018 0.0637 0.1747
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0095 0.0095
Schistosoma mansoni apoferritin-2 0.0012 0.0013 0.0007
Echinococcus granulosus cpg binding protein 0.009 0.0301 0.0931
Mycobacterium tuberculosis Conserved protein 0.0035 0.0098 0.0285
Loa Loa (eye worm) transcription factor SMAD2 0.0257 0.0923 0.2532
Schistosoma mansoni smad 0.0018 0.0034 0.0063
Echinococcus multilocularis translational activator gcn1 0.0014 0.0021 0.0021
Loa Loa (eye worm) mbt repeat family protein 0.0165 0.0582 0.1596
Loa Loa (eye worm) F/Y-rich family protein 0.0011 0.0011 0.0029
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0018 0.0037 0.0037
Echinococcus multilocularis neuropeptide s receptor 0.0317 0.1143 0.1143
Schistosoma mansoni ran 0.0041 0.0119 0.0294
Schistosoma mansoni importin beta-1 0.0075 0.0247 0.0639
Schistosoma mansoni hypothetical protein 0.0073 0.024 0.062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0122 0.0285
Brugia malayi Protein cec-1. 0.0024 0.0056 0.0155
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0091 0.0305 0.0305
Echinococcus multilocularis geminin 0.0365 0.1323 0.1323
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0172 0.0605 0.1608
Echinococcus granulosus mitogen activated protein kinase 0.0035 0.01 0.0309
Echinococcus multilocularis chromobox protein 1 0.0145 0.0505 0.0505
Mycobacterium tuberculosis Conserved protein 0.0035 0.0098 0.0285
Echinococcus multilocularis inositol monophosphatase 1 0.0027 0.0069 0.0069
Schistosoma mansoni importin-beta 2 0.0014 0.0021 0.0029
Trypanosoma cruzi polo-like protein kinase, putative 0.0177 0.0623 1
Trichomonas vaginalis CAMK family protein kinase 0.0177 0.0623 0.1492
Loa Loa (eye worm) hypothetical protein 0.0659 0.2413 0.6618
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0809 0.2968 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0637 0.1747
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0074
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0094 0.0316 0.4913
Echinococcus granulosus neuropeptide receptor A26 0.0317 0.1143 0.3529
Loa Loa (eye worm) hypothetical protein 0.0181 0.0639 0.1753
Schistosoma mansoni survival motor neuron protein 0.0132 0.0457 0.1208
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0122 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0205 0.0728 0.194
Trypanosoma brucei importin beta-1 subunit, putative 0.0075 0.0247 0.3959
Echinococcus granulosus PHD and RING finger domain containing protein 1 0.0011 0.0011 0.0032
Onchocerca volvulus 0.0064 0.0204 0.0468
Echinococcus granulosus GPCR family 2 0.0097 0.0328 0.1013
Entamoeba histolytica hypothetical protein 0.0067 0.0217 0.3275
Onchocerca volvulus 0.0035 0.0098 0.021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0069 0.0158
Loa Loa (eye worm) hypothetical protein 0.0165 0.0582 0.1596
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0056 0.0126
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0094 0.0316 0.4991

Activities

Activity type Activity value Assay description Source Reference
-logMIC (functional) = 1.68 Antifungal activity against Candida albicans after 48 hrs by tube dilution method ChEMBL. 19081655
-logMIC (functional) = 2.58 Antibacterial activity against Escherichia coli after 24 hrs by tube dilution method ChEMBL. 19081655

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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