Detailed information for compound 1034743

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.76 | Formula: C22H20Cl3N
  • H donors: 1 H acceptors: 0 LogP: 6.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1Cl)C1CC(c2c1cccc2)NCc1ccccc1.Cl
  • InChi: 1S/C22H19Cl2N.ClH/c23-20-11-10-16(12-21(20)24)19-13-22(18-9-5-4-8-17(18)19)25-14-15-6-2-1-3-7-15;/h1-12,19,22,25H,13-14H2;1H
  • InChiKey: NXXPIYRRDABJLN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0035
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0026 0.0151
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0026 0.0083
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0004 0.5
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0157 0.0713 0.1173
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0035
Toxoplasma gondii hypothetical protein 0.005 0.0195 0.2694
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0535 0.2544 1
Plasmodium vivax hypothetical protein, conserved 0.005 0.0195 0.2354
Schistosoma mansoni smad 0.0035 0.0123 0.0123
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0035 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0176 0.0807 0.3148
Leishmania major cathepsin L-like protease 0.0063 0.0261 0.1752
Loa Loa (eye worm) ctsf protein 0.0017 0.0035 0.012
Plasmodium vivax acyl-CoA synthetase, putative 0.0132 0.0592 0.8207
Brugia malayi Bromodomain containing protein 0.0075 0.0318 0.1221
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0009 0.0009
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0009 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0012 0.0012
Trichomonas vaginalis antibiotic synthetase, putative 0.0052 0.0205 0.0775
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0238
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0196 0.0903 0.3539
Onchocerca volvulus 0.0261 0.1215 0.6442
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.0713 0.2778
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.009 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0009 0.0009
Echinococcus granulosus cathepsin l1 0.0017 0.0035 0.0035
Brugia malayi ecdysteroid receptor 0.0011 0.0009 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0009 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0157 0.0713 0.8441
Loa Loa (eye worm) fibroinase 0.0017 0.0035 0.012
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0455
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0157 0.0713 0.1173
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0205 0.0775
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.009 0.009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0176 0.0807 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0026 0.0151
Loa Loa (eye worm) hypothetical protein 0.0171 0.0784 0.3069
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.1367 0.1367
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.1367 0.5367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0178 0.0178
Echinococcus multilocularis tumor protein p63 0.178 0.8566 0.8566
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0296 0.0296
Onchocerca volvulus 0.0398 0.1882 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0009 0.0018
Onchocerca volvulus 0.0052 0.0205 0.1049
Loa Loa (eye worm) hypothetical protein 0.0261 0.1215 0.4769
Schistosoma mansoni hypothetical protein 0.0398 0.1882 0.1882
Onchocerca volvulus 0.0052 0.0205 0.1049
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.1367 0.5367
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0205 0.0075
Trichomonas vaginalis antibiotic synthetase, putative 0.0052 0.0205 0.0775
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0261 0.1752
Onchocerca volvulus 0.005 0.0195 0.0993
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0176 0.0807 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Echinococcus granulosus Smad4 0.0035 0.0123 0.0123
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Brugia malayi MH1 domain containing protein 0.0035 0.0123 0.0452
Mycobacterium ulcerans acyl-CoA synthetase 0.0176 0.0807 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0103 0.0103
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0035 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0237
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0123 0.0467
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0111 0.0733
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0111 0.1516
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0166 0.1107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0009 0.0003
Entamoeba histolytica acyl-coA synthetase, putative 0.0176 0.0807 0.3148
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0229 0.1063 0.4169
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0195 0.0195
Brugia malayi hypothetical protein 0.0035 0.0124 0.0455
Brugia malayi Ras protein let-60 0.0535 0.2544 1
Brugia malayi beta-lactamase family protein 0.0157 0.0713 0.2778
Loa Loa (eye worm) hypothetical protein 0.0027 0.0085 0.0314
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0055 0.0349
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0026 0.0151
Loa Loa (eye worm) hypothetical protein 0.0075 0.0319 0.1238
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0026 0.0067
Echinococcus granulosus lamin dm0 0.0058 0.0234 0.0234
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.0713 0.4837
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0009 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0092 0.0329
Echinococcus multilocularis GPCR, family 2 0.0062 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0058 0.0234 0.0903
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Brugia malayi MH1 domain containing protein 0.0019 0.0048 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0176 0.0807 0.3148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.003 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0123 0.0814
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0009 0.0009
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Leishmania major hypothetical protein, conserved 0.0157 0.0713 0.4837
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0753 0.1259
Schistosoma mansoni bromodomain containing protein 0.0126 0.0564 0.0564
Echinococcus multilocularis cpg binding protein 0.0039 0.0142 0.0142
Schistosoma mansoni smad 0.0016 0.003 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Onchocerca volvulus 0.0157 0.0713 0.376
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.1367 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0238
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0052 0.0205 0.0775
Echinococcus multilocularis beta LACTamase domain containing family member 0.0157 0.0713 0.0713
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0205 0.0075
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0016
Onchocerca volvulus 0.0033 0.0114 0.0564
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0035 0.0215
Onchocerca volvulus 0.0176 0.0807 0.4261
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0009 0.0009
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.2694
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.147 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0176 0.0807 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0205 0.1374
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0557 0.0835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Trypanosoma cruzi ISWI complex protein 0.003 0.01 0.0658
Brugia malayi MH1 domain containing protein 0.0019 0.0048 0.0155
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0455
Brugia malayi MH2 domain containing protein 0.0511 0.2425 0.9534
Schistosoma mansoni hypothetical protein 0.0047 0.0181 0.0181
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.0713 0.2778
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0104 0.0393
Mycobacterium ulcerans hypothetical protein 0.0176 0.0807 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Echinococcus multilocularis lamin 0.0058 0.0234 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0255 0.0972
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0255 0.0255
Onchocerca volvulus 0.0157 0.0713 0.376
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0968 0.3793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0111 0.0733
Trypanosoma cruzi ISWI complex protein 0.003 0.01 0.0658
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0103 0.0103
Echinococcus granulosus GPCR family 2 0.0062 0.0255 0.0255
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0124 0.0124
Echinococcus granulosus mothers against decapentaplegic 2 0.0016 0.003 0.003
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0672 0.4558
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0035
Toxoplasma gondii cathepsin CPL 0.0017 0.0035 0.0445
Brugia malayi MH1 domain containing protein 0.0035 0.0123 0.0452
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0166 0.0621
Trichomonas vaginalis rotamase, putative 0.0032 0.0111 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0237
Trichomonas vaginalis ras-dva small GTPase, putative 0.0535 0.2544 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Toxoplasma gondii hypothetical protein 0.005 0.0195 0.2694
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0101
Plasmodium falciparum acyl-CoA synthetase 0.0132 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Schistosoma mansoni zinc finger protein 0.004 0.015 0.015
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0009 0.0009
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0166 0.1107
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0035 0.0215
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0672 0.4558
Mycobacterium ulcerans acyl-CoA synthetase 0.0176 0.0807 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0341 0.1326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0281
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0114 0.0432
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.1367 0.1367
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0111 0.0733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Echinococcus granulosus lamin 0.0058 0.0234 0.0234
Schistosoma mansoni acetyl-CoA synthetase 0.0052 0.0205 0.0205
Schistosoma mansoni hypothetical protein 0.0062 0.0255 0.0255
Onchocerca volvulus 0.0052 0.0205 0.1049
Loa Loa (eye worm) RNA binding protein 0.0195 0.0899 0.3524
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0205 0.0075
Plasmodium vivax SET domain protein, putative 0.0031 0.0103 0.1004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0166 0.1107
Echinococcus granulosus smad 0.0035 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0171 0.0784 0.3069
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0261 0.1752
Loa Loa (eye worm) hypothetical protein 0.0176 0.0807 0.3159
Schistosoma mansoni inhibitor of apoptosis protein 0.0398 0.1882 0.1882
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0035 0.0105
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0157 0.0713 0.1173
Mycobacterium ulcerans hypothetical protein 0.0165 0.0753 0.9108
Schistosoma mansoni cpg binding protein 0.0039 0.0142 0.0142
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0398 0.1882 0.1882
Loa Loa (eye worm) hypothetical protein 0.0292 0.1367 0.5367
Brugia malayi Pre-SET motif family protein 0.0031 0.0103 0.0373
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0205 0.1374
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0009 0.0009
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0135 0.0499
Onchocerca volvulus 0.0031 0.0103 0.0505
Schistosoma mansoni Smad4 0.0016 0.003 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0124 0.0124
Echinococcus multilocularis expressed protein 0.0033 0.0115 0.0115
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0195 0.0195
Onchocerca volvulus 0.0058 0.0234 0.1202
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0111 0.0404
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0132 0.0592 0.091
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Loa Loa (eye worm) hypothetical protein 0.0085 0.0369 0.1433
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.0713 0.2778
Echinococcus multilocularis Smad4 0.0035 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0062 0.0255 0.0255
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0123 0.0467
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0234 0.0888
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0052 0.0205 0.0789
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0178 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0237
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0009 0.0009
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0052 0.0205 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) hypothetical protein 0.0062 0.0255 0.0986
Brugia malayi MH2 domain containing protein 0.0035 0.0123 0.0452
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0265 0.0265
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0195 0.0195
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0139 0.0626 0.2446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0123 0.0123
Leishmania major acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Echinococcus multilocularis transient receptor potential cation channel 0.0169 0.0773 0.0773
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0035 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Plasmodium vivax amine transporter, putative 0.005 0.0195 0.2354
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0557 0.0835
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Trichomonas vaginalis penicillin-binding protein, putative 0.0157 0.0713 0.2778
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0103 0.0103
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0398 0.1882 0.7394
Onchocerca volvulus Deterin homolog 0.0398 0.1882 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0009 0.0018
Onchocerca volvulus 0.0157 0.0713 0.376
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0085
Mycobacterium ulcerans esterase/lipase LipP 0.0157 0.0713 0.8441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.0205 0.0775
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0026 0.0151
Schistosoma mansoni smad1 5 8 and 0.0035 0.0123 0.0123
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0195 0.0195
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0123 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0009 0.0018
Mycobacterium ulcerans lipase LipD 0.0157 0.0713 0.8441
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0009 0.0009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0119 0.053 0.053
Entamoeba histolytica acyl-CoA synthetase, putative 0.0176 0.0807 0.3148
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0176 0.0807 0.1375
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0009 0.0004
Brugia malayi Smad1 0.0035 0.0123 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0009 0.0003
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0195 0.0195
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0009 0.0009
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0166 0.0166
Echinococcus granulosus zinc finger protein 0.004 0.015 0.015
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0195 0.0195
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.0151
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0009 0.0003
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0052 0.0205 0.0075
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0157 0.0713 0.2778
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0115 0.0419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Schistosoma mansoni Smad4 0.0035 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0171
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.001 0.001
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0195 0.0195
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0166 0.0621
Leishmania major cathepsin L-like protease 0.0063 0.0261 0.1752
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0205 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Mycobacterium ulcerans beta-lactamase 0.0157 0.0713 0.8441
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0195 0.0195
Entamoeba histolytica ras-1, putative 0.0535 0.2544 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0035
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0123 0.0123
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0052 0.0205 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0195 0.1306
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0398 0.1882 0.7389
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0166 0.0621
Toxoplasma gondii hypothetical protein 0.0051 0.0199 0.2759
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0009 0.0009
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0195 0.0195
Schistosoma mansoni lamin 0.0058 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0134 0.0603 0.0603
Plasmodium vivax hypothetical protein, conserved 0.0157 0.0713 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0026 0.0026
Loa Loa (eye worm) beta-lactamase 0.0157 0.0713 0.279
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0265 0.0265
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0111 0.0733
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0285 0.3962
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0027 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0176 0.0807 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0035 0.0142
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.003 0.0101
Trichomonas vaginalis rheb, putative 0.0535 0.2544 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0009 0.0003
Echinococcus multilocularis musashi 0.0058 0.0234 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.0105
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0117 0.0117
Toxoplasma gondii ABC1 family protein 0.0157 0.0713 1
Brugia malayi hypothetical protein 0.0229 0.1063 0.416
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0115 0.0419
Echinococcus granulosus dnaJ subfamily B 0.0469 0.2225 0.2225
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0052 0.0205 0.0075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0234 0.0903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.0286
Mycobacterium tuberculosis Conserved protein 0.0157 0.0713 0.1173
Echinococcus granulosus intermediate filament protein 0.0058 0.0234 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0009 0.0018
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0117 0.0117
Echinococcus multilocularis mothers against decapentaplegic 6 0.0016 0.003 0.003
Mycobacterium leprae Probable lipase LipE 0.0157 0.0713 0.8441
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0883
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0052 0.0205 0.0775
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0009 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0009 0.0003
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.2694
Brugia malayi Pre-SET motif family protein 0.0209 0.0968 0.3783
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Echinococcus granulosus cpg binding protein 0.0039 0.0142 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0009 0.0018
Brugia malayi CXXC zinc finger family protein 0.0033 0.0114 0.0417
Echinococcus granulosus serotonin transporter 0.0292 0.1367 0.1367
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Onchocerca volvulus 0.0052 0.0205 0.1049
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.0142
Mycobacterium tuberculosis Probable esterase LipL 0.0157 0.0713 0.1173
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.147 1
Echinococcus granulosus expressed protein 0.0033 0.0115 0.0115
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0035
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0205 0.1374
Schistosoma mansoni hypothetical protein 0.0035 0.0124 0.0124
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0255 0.0255
Entamoeba histolytica Ras family GTPase 0.0535 0.2544 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0603 0.2357
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0195 0.0734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0009 0.0009
Brugia malayi MH2 domain containing protein 0.0035 0.0123 0.0452
Leishmania major hypothetical protein, conserved 0.003 0.01 0.0658
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0123 0.0123
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0009 0.0009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0196 0.0903 0.3528
Echinococcus multilocularis microtubule associated protein 2 0.2077 1 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.1367 0.5367
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0009 0.0003
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0178 0.0178
Brugia malayi intermediate filament protein 0.0058 0.0234 0.0888
Toxoplasma gondii propionate-CoA ligase 0.0052 0.0205 0.284
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0052 0.0205 0.0075
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0026 0.0026
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0195 0.0195
Onchocerca volvulus 0.0047 0.0181 0.092
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Echinococcus multilocularis ankyrin repeat protein 0.0166 0.0757 0.0757
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0176 0.0807 0.1375
Entamoeba histolytica cysteine protease, putative 0.0017 0.0035 0.0105
Trichomonas vaginalis GTP-binding protein rit, putative 0.0535 0.2544 1
Trichomonas vaginalis rotamase, putative 0.0033 0.0115 0.0419
Onchocerca volvulus 0.0017 0.0035 0.0142
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.1367 0.536
Schistosoma mansoni lamin 0.0058 0.0234 0.0234
Entamoeba histolytica Ras family GTPase 0.0535 0.2544 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0176 0.0807 1
Schistosoma mansoni zinc finger protein 0.003 0.01 0.01
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0195 0.0195
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0166 0.0166
Leishmania major acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Loa Loa (eye worm) oxidoreductase 0.0052 0.0205 0.0789
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0166 0.1107
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0168 0.1121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) cysteine protease 0.0017 0.0035 0.012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0298 0.0298
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0205 0.0775
Onchocerca volvulus 0.0017 0.0035 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0009 0.0003
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Echinococcus granulosus mothers against decapentaplegic 6 0.0016 0.003 0.003
Echinococcus multilocularis mothers against decapentaplegic 2 0.0016 0.003 0.003
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0151 0.0575
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1063 0.1063
Onchocerca volvulus 0.0011 0.0009 0.0004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0168 0.1121
Giardia lamblia GTOR 0.0044 0.0166 0.5
Brugia malayi nuclear hormone receptor 0.0011 0.0009 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0097 0.0347
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0094 0.0094
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0035
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.147 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0749
Schistosoma mansoni smad1 5 8 and 0.0035 0.0123 0.0123
Echinococcus multilocularis inhibitor of apoptosis protein 0.0398 0.1882 0.1882
Loa Loa (eye worm) hypothetical protein 0.0176 0.0807 0.3159
Leishmania major 4-coumarate:coa ligase-like protein 0.0176 0.0807 0.5476
Brugia malayi AMP-binding enzyme family protein 0.0176 0.0807 0.3148
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Plasmodium falciparum transporter, putative 0.005 0.0195 0.2868
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0261 0.1752
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0168 0.1121
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0166 0.1107
Schistosoma mansoni hypothetical protein 0.0469 0.2225 0.2225
Schistosoma mansoni hypothetical protein 0.003 0.01 0.01
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0016 0.003 0.0115
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0234 0.1571
Echinococcus multilocularis muscleblind protein 1 0.0171 0.0784 0.0784
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0205 0.1374
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) hypothetical protein 0.0292 0.1367 0.5367
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0749
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0123 0.0814
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0103 0.1404
Schistosoma mansoni microtubule-associated protein tau 0.2077 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Echinococcus multilocularis zinc finger protein 0.004 0.015 0.015
Loa Loa (eye worm) nuclear factor I 0.0019 0.0048 0.0171
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0195 0.0195
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0009 0.0009
Brugia malayi follicle stimulating hormone receptor 0.0466 0.2209 0.8679
Brugia malayi steroid hormone receptor 0.0011 0.0009 0.0003
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0052 0.0205 0.3054
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0261 0.1752
Trichomonas vaginalis rap1 and, putative 0.0535 0.2544 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0557 0.0835
Loa Loa (eye worm) hypothetical protein 0.0028 0.009 0.0334
Schistosoma mansoni hypothetical protein 0.0062 0.0255 0.0255
Plasmodium vivax acetyl-CoA synthetase, putative 0.0052 0.0205 0.2507
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.0713 0.4837
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0115 0.0434
Brugia malayi nuclear receptor NHR-88 0.0011 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0064 0.0265 0.1025
Onchocerca volvulus 0.0058 0.0234 0.1202
Onchocerca volvulus 0.0238 0.1107 0.5863
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0157 0.0713 0.0713
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0052 0.0205 0.0075
Brugia malayi Calcitonin receptor-like protein seb-1 0.0196 0.0903 0.3528
Loa Loa (eye worm) hypothetical protein 0.0398 0.1882 0.7394
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.0603 0.2345
Onchocerca volvulus 0.0017 0.0035 0.0142
Echinococcus granulosus muscleblind protein 0.0171 0.0784 0.0784
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0112 0.1527
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.2694
Schistosoma mansoni hypothetical protein 0.0062 0.0255 0.0255
Brugia malayi beta-lactamase family protein 0.0157 0.0713 0.2778
Brugia malayi hypothetical protein 0.005 0.0195 0.0734
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0166 0.1107
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Echinococcus granulosus inhibitor of apoptosis protein 0.0398 0.1882 0.1882
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0176 0.0807 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0205 0.0789
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0132 0.0592 0.6421
Loa Loa (eye worm) hypothetical protein 0.0027 0.0085 0.0314
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0205 0.0775
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0398 0.1882 0.7389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0255 0.0972
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0009 0.0003
Echinococcus granulosus ankyrin repeat protein 0.0166 0.0757 0.0757
Mycobacterium tuberculosis Conserved protein 0.0157 0.0713 0.1173
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.012
Echinococcus granulosus tar DNA binding protein 0.0195 0.0899 0.0899
Loa Loa (eye worm) TAR-binding protein 0.0195 0.0899 0.3524
Echinococcus granulosus ras gtpase 0.0535 0.2544 0.2544
Loa Loa (eye worm) Ras protein let-60 0.0535 0.2544 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0176 0.0807 0.5476
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0009 0.0003
Schistosoma mansoni rotamase 0.0033 0.0115 0.0115
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0052 0.0205 0.284
Echinococcus multilocularis lamin dm0 0.0058 0.0234 0.0234
Echinococcus granulosus transient receptor potential cation channel 0.0169 0.0773 0.0773
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0672 0.4558
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0455
Echinococcus multilocularis tar DNA binding protein 0.0195 0.0899 0.0899
Mycobacterium leprae conserved hypothetical protein 0.0157 0.0713 0.8441
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.147 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0195 0.0195
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0181 0.068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0557 0.0835
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0166 0.0757 0.0757
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0052 0.0205 0.0789
Brugia malayi RNA binding protein 0.0195 0.0899 0.3514
Loa Loa (eye worm) MH2 domain-containing protein 0.0511 0.2425 0.9534
Brugia malayi RNA recognition motif domain containing protein 0.0195 0.0899 0.3514
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0052 0.0205 0.284
Trichomonas vaginalis dexras1, putative 0.0535 0.2544 1
Onchocerca volvulus 0.005 0.0195 0.0993
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Plasmodium falciparum amino acid transporter, putative 0.005 0.0195 0.2868
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0195 0.0899 0.3524
Mycobacterium ulcerans hypothetical protein 0.0157 0.0713 0.8441
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0215 0.1439
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0009 0.0009
Schistosoma mansoni Smad4 0.0016 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.0176 0.0807 0.3148
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0016
Brugia malayi PHD-finger family protein 0.0051 0.02 0.0756
Mycobacterium tuberculosis Probable lipase LipE 0.0157 0.0713 0.1173
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0009 0.0009
Echinococcus multilocularis muscleblind protein 0.0171 0.0784 0.0784
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0734
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0009 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0255 0.0255
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0255 0.0986
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0205 0.0775
Brugia malayi beta-lactamase 0.0157 0.0713 0.2778
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0132 0.0592 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0035 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0238
Trichomonas vaginalis ral, putative 0.0535 0.2544 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0157 0.0713 0.279
Loa Loa (eye worm) histone methyltransferase 0.0011 0.001 0.002
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0009 0.0003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0035
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0234 0.0903
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1001 0.4798 1
Brugia malayi TAR-binding protein 0.0195 0.0899 0.3514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0009 0.0003
Onchocerca volvulus 0.0017 0.0035 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Schistosoma mansoni cpg binding protein 0.0039 0.0142 0.0142
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0009 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0255 0.0255
Echinococcus multilocularis smad 0.0035 0.0123 0.0123
Brugia malayi mothers against decapentaplegic homolog 3 0.0016 0.003 0.0085
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0166 0.0635
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Schistosoma mansoni survival motor neuron protein 0.0047 0.0181 0.0181
Mycobacterium tuberculosis Probable hydrolase 0.0157 0.0713 0.1173
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0168 0.1121
Onchocerca volvulus 0.0017 0.0035 0.0142
Trichomonas vaginalis esterase, putative 0.0157 0.0713 0.2778
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Onchocerca volvulus 0.005 0.0195 0.0993
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1107 0.4333
Echinococcus multilocularis serotonin transporter 0.0292 0.1367 0.1367
Mycobacterium tuberculosis Conserved protein 0.0157 0.0713 0.1173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0157 0.0713 0.0713
Onchocerca volvulus 0.0017 0.0035 0.0142
Schistosoma mansoni cpg binding protein 0.0033 0.0114 0.0114
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.001 0.001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0026 0.0151
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0124 0.0124
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0195 0.0195
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0195 0.0195
Brugia malayi Muscleblind-like protein 0.0171 0.0784 0.3058
Onchocerca volvulus 0.0292 0.1367 0.7253
Loa Loa (eye worm) Smad1 0.0035 0.0123 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0009 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.0286
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0455
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0398 0.1882 0.1882
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0009 0.0009
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0104 0.0378
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0117 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Echinococcus granulosus tumor protein p63 0.178 0.8566 0.8566
Brugia malayi Ras-related protein R-Ras2 0.0535 0.2544 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0157 0.0713 0.1173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) hypothetical protein 0.0052 0.0205 0.0789
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0123 0.0814
Onchocerca volvulus 0.0017 0.0035 0.0142
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0195 0.0195
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0026 0.0151
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0195 0.0195
Echinococcus multilocularis dnaJ subfamily B 0.0469 0.2225 0.2225
Brugia malayi Bromodomain containing protein 0.0149 0.0675 0.263
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0035 0.012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0009 0.0003
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0052 0.0205 0.0075
Loa Loa (eye worm) transcription factor SMAD2 0.0511 0.2425 0.9534
Loa Loa (eye worm) hypothetical protein 0.0176 0.0807 0.3159
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1063 0.1063
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0117 0.0117
Leishmania major 4-coumarate:coa ligase-like protein 0.0176 0.0807 0.5476
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0052 0.0205 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.0286
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0195 0.0195
Schistosoma mansoni cellular tumor antigen P53 0.0261 0.1215 0.1215
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0166 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0238
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0123 0.0123
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.0142
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0009 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0157 0.0713 0.2778
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0052 0.0205 0.0205
Echinococcus granulosus cathepsin l1 0.0011 0.0009 0.0009
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0466 0.2209 0.8681
Loa Loa (eye worm) hypothetical protein 0.0196 0.0903 0.3539
Echinococcus multilocularis ras gtpase 0.0535 0.2544 0.2544
Schistosoma mansoni coup transcription factor 0.0011 0.0009 0.0009
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0043 0.0266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0265 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0281
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0009 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0157 0.0713 0.4837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0166 0.0621
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0265 0.0265
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0176 0.0807 1
Schistosoma mansoni smad1 5 8 and 0.0035 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Leishmania major cathepsin L-like protease 0.0063 0.0261 0.1752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Echinococcus granulosus beta LACTamase domain containing family member 0.0157 0.0713 0.0713
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0195 0.0195
Trypanosoma brucei ISWI complex protein 0.003 0.01 0.0658
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0119 0.053 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Schistosoma mansoni bromodomain containing protein 0.001 0.0005 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0166 0.0621
Loa Loa (eye worm) serotonin transporter b 0.0292 0.1367 0.5367
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0398 0.1882 0.1882
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Schistosoma mansoni intermediate filament proteins 0.0058 0.0234 0.0234

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 47 uM kg-1 Antagonistic activity against 5-HTP induced potentiation in mice ChEMBL. 2999402
ED50 (functional) > 50 uM kg-1 Antagonistic activity against tetrabenazine-induced ptosis in mice. ChEMBL. 2999402
ED50 (functional) > 198 uM kg-1 Antagonistic activity against tetrabenazine-induced ptosis in mice. ChEMBL. 2999402
ED50 (functional) = 207 uM kg-1 Antagonistic activity against 5-HTP induced potentiation in mice ChEMBL. 2999402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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