Detailed information for compound 104411

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 223.23 | Formula: C13H9N3O
  • H donors: 1 H acceptors: 4 LogP: 1.72 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(n1)ccc(c2)c1ccnnc1
  • InChi: 1S/C13H9N3O/c17-13-4-2-10-7-9(1-3-12(10)16-13)11-5-6-14-15-8-11/h1-8H,(H,16,17)
  • InChiKey: ZHOZFTGMEIFRAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin beta 4A class IVa 0.0486 0.6585 0.6574
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0052 0.0061
Schistosoma mansoni tubulin subunit beta 0.0486 0.6585 0.6574
Schistosoma mansoni tubulin subunit gamma 0.0263 0.3471 0.345
Brugia malayi Tubulin alpha chain 0.0368 0.4929 0.7484
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0322 0.2134
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.1572 0.487
Leishmania major zeta tubulin, putative 0.0114 0.1388 0.2068
Brugia malayi tubulin alpha-2 chain 0.0368 0.4929 0.7484
Leishmania major cytochrome p450-like protein 0.0019 0.0052 0.0029
Plasmodium vivax tubulin alpha chain, putative 0.0368 0.4929 0.7484
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0062 0.0089
Loa Loa (eye worm) hypothetical protein 0.0219 0.2846 0.4319
Loa Loa (eye worm) tubulin beta chain 0.0486 0.6585 1
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0537 0.0812
Leishmania major beta tubulin 0.0486 0.6585 1
Echinococcus granulosus tubulin delta chain 0.0114 0.1388 0.136
Echinococcus granulosus intermediate filament protein 0.0029 0.0188 0.0156
Leishmania major beta tubulin 0.0486 0.6585 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0052 0.0061
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Echinococcus granulosus tubulin subunit beta 0.0486 0.6585 0.6574
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0322 0.1776
Loa Loa (eye worm) alpha-tubulin 0.0368 0.4929 0.7484
Trypanosoma brucei beta tubulin 0.0486 0.6585 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.2117 0.3212
Echinococcus multilocularis 0.0019 0.0052 0.0019
Entamoeba histolytica tubulin alpha-1 chain 0.0368 0.4929 0.7462
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0052 0.0142
Loa Loa (eye worm) tubulin alpha-2 chain 0.0368 0.4929 0.7484
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0114 0.1388 0.2107
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0537 0.0769
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0033 0.5
Loa Loa (eye worm) tubulin alpha chain 0.0368 0.4929 0.7484
Giardia lamblia Delta tubulin 0.0114 0.1388 0.2068
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0312 0.0469
Schistosoma mansoni alpha tubulin 0.0368 0.4929 0.4912
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.007
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0537 0.0769
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0062 0.0029
Schistosoma mansoni hypothetical protein 0.0166 0.2117 0.2091
Leishmania major beta tubulin 0.0486 0.6585 1
Brugia malayi beta-lactamase 0.0038 0.0322 0.0485
Giardia lamblia Alpha-tubulin 0.0368 0.4929 0.7473
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0322 0.0441
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0423 0.0595
Echinococcus multilocularis tubulin alpha 0.0263 0.3471 0.345
Trichomonas vaginalis tubulin alpha chain, putative 0.0149 0.1872 0.2808
Brugia malayi Tubulin beta chain 0.0149 0.1872 0.284
Echinococcus granulosus tubulin beta 1 chain 0.0486 0.6585 0.6574
Mycobacterium tuberculosis Probable reductase 0.0115 0.1393 0.4304
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0503 0.076
Trichomonas vaginalis tubulin beta chain, putative 0.0368 0.4929 0.7473
Echinococcus granulosus Tubulin beta 2C chain 0.0486 0.6585 0.6574
Echinococcus multilocularis tumor protein p63 0.035 0.4688 0.467
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0619 0.0936
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.0044
Echinococcus granulosus small conductance calcium activated potassium 0.0166 0.2117 0.2091
Trichomonas vaginalis tubulin epsilon chain, putative 0.0368 0.4929 0.7473
Trichomonas vaginalis tubulin gamma chain, putative 0.0486 0.6585 1
Schistosoma mansoni tubulin subunit beta 0.0486 0.6585 0.6574
Trypanosoma cruzi zeta tubulin, putative 0.0114 0.1388 0.2068
Echinococcus multilocularis tubulin epsilon chain 0.0263 0.3471 0.345
Schistosoma mansoni tubulin subunit beta 0.0486 0.6585 0.6574
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.037 0.0515
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0052 0.0061
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0052 0.0061
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0423 0.0638
Trypanosoma cruzi alpha tubulin, putative 0.0368 0.4929 0.7473
Echinococcus granulosus tubulin alpha chain 0.0368 0.4929 0.4912
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0312 0.0469
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0052 0.0142
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0324 0.0292
Toxoplasma gondii beta-1 tubulin, putative 0.0486 0.6585 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0537 0.0769
Loa Loa (eye worm) hypothetical protein 0.0028 0.0181 0.027
Loa Loa (eye worm) tubulin beta-2A chain 0.0486 0.6585 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0368 0.4929 0.4912
Leishmania major hypothetical protein, conserved 0.0038 0.0322 0.0441
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0052 0.0061
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0322 0.0915
Echinococcus granulosus tubulin alpha 1C chain 0.0368 0.4929 0.4912
Echinococcus multilocularis small conductance calcium activated potassium 0.0166 0.2117 0.2091
Loa Loa (eye worm) BEN-1 protein 0.0486 0.6585 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.1393 0.4304
Trichomonas vaginalis tubulin beta chain, putative 0.0368 0.4929 0.7473
Loa Loa (eye worm) hypothetical protein 0.0029 0.0188 0.0281
Echinococcus multilocularis tubulin beta 1 chain 0.0486 0.6585 0.6574
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.0044
Entamoeba histolytica hypothetical protein 0.0038 0.0324 0.0402
Echinococcus granulosus tumor protein p63 0.035 0.4688 0.467
Loa Loa (eye worm) glutathione reductase 0.005 0.0492 0.0743
Echinococcus multilocularis Tubulin beta 2C chain 0.0486 0.6585 0.6574
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0052 0.0142
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.1572 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0322 0.0441
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0114 0.1388 0.2068
Trypanosoma brucei alpha tubulin 0.0368 0.4929 0.7473
Trypanosoma cruzi tubulin gamma chain 0.0263 0.3471 0.5248
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0052 0.0061
Trichomonas vaginalis tubulin, putative 0.0149 0.1872 0.2808
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0219 0.2846 0.4293
Loa Loa (eye worm) tubulin beta-1 chain 0.0486 0.6585 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.1572 0.487
Echinococcus multilocularis Tubulin beta 2C chain 0.0486 0.6585 0.6574
Mycobacterium ulcerans lipase LipD 0.0038 0.0322 0.2134
Loa Loa (eye worm) tubulin gamma chain 0.0263 0.3471 0.5269
Echinococcus granulosus tubulin alpha 0.0263 0.3471 0.345
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0322 0.0915
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.1393 0.4304
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0322 0.029
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.0052 0.0142
Trichomonas vaginalis tubulin alpha chain, putative 0.0149 0.1872 0.2808
Echinococcus multilocularis tubulin gamma 1 chain 0.0263 0.3471 0.345
Leishmania major beta tubulin 0.0486 0.6585 1
Echinococcus granulosus lamin dm0 0.0029 0.0188 0.0156
Echinococcus granulosus tubulin alpha chain 0.0368 0.4929 0.4912
Leishmania major beta tubulin 0.0486 0.6585 1
Trypanosoma brucei alpha tubulin 0.0368 0.4929 0.7473
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0492 0.0701
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.0485
Plasmodium falciparum glutathione reductase 0.005 0.0492 0.0701
Echinococcus multilocularis Tubulin alpha 1 chain 0.0368 0.4929 0.4912
Loa Loa (eye worm) tubulin alpha 2 0.0104 0.1247 0.189
Loa Loa (eye worm) tubulin alpha chain 0.0368 0.4929 0.7484
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Schistosoma mansoni tubulin subunit beta 0.0486 0.6585 0.6574
Trypanosoma brucei epsilon tubulin 0.0263 0.3471 0.5248
Trichomonas vaginalis tubulin alpha chain, putative 0.0149 0.1872 0.2808
Loa Loa (eye worm) beta-tubulin 0.0486 0.6585 1
Onchocerca volvulus 0.0038 0.0322 0.0724
Schistosoma mansoni alpha tubulin 0.0368 0.4929 0.4912
Leishmania major hypothetical protein, conserved 0.0053 0.0537 0.0769
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0149 0.1872 0.2808
Loa Loa (eye worm) tubulin beta-4 chain 0.0486 0.6585 1
Entamoeba histolytica hypothetical protein 0.0038 0.0324 0.0402
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0486 0.6585 0.6574
Mycobacterium leprae cell division protein FtsZ 0.0114 0.1388 0.879
Trypanosoma brucei alpha tubulin 0.0368 0.4929 0.7473
Schistosoma mansoni tubulin subunit alpha 0.0368 0.4929 0.4912
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0322 0.0441
Leishmania major beta tubulin 0.0486 0.6585 1
Brugia malayi hypothetical protein 0.0035 0.0272 0.0409
Loa Loa (eye worm) hypothetical protein 0.0253 0.333 0.5055
Loa Loa (eye worm) tubulin beta chain 0.0114 0.1388 0.2104
Loa Loa (eye worm) hypothetical protein 0.0053 0.0537 0.0811
Echinococcus multilocularis Tubulin alpha 1 chain 0.0368 0.4929 0.4912
Echinococcus multilocularis tubulin alpha 1C chain 0.0368 0.4929 0.4912
Brugia malayi hypothetical protein 0.0161 0.2036 0.3088
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0105 0.011
Entamoeba histolytica tubulin gamma chain 0.0263 0.3471 0.5226
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0033 0.0046
Trichomonas vaginalis tubulin epsilon chain, putative 0.0486 0.6585 1
Toxoplasma gondii beta-tubulin, putative 0.0486 0.6585 1
Echinococcus granulosus Tubulin beta 2C chain 0.0486 0.6585 0.6574
Schistosoma mansoni cytochrome P450 0.0019 0.0052 0.0019
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0033 0.005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0062 0.0044
Plasmodium vivax tubulin beta chain, putative 0.0486 0.6585 1
Schistosoma mansoni tubulin subunit alpha 0.0368 0.4929 0.4912
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0052 0.0061
Mycobacterium ulcerans beta-lactamase 0.0038 0.0322 0.2134
Echinococcus granulosus geminin 0.0355 0.4753 0.4736
Plasmodium vivax tubulin gamma chain, putative 0.0263 0.3471 0.5269
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0062 0.0092
Schistosoma mansoni alpha tubulin 0.0368 0.4929 0.4912
Loa Loa (eye worm) beta-lactamase 0.0038 0.0322 0.0485
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.1884 0.1857
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.1944 0.2949
Brugia malayi Tubulin beta chain 0.0114 0.1388 0.2104
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0052 0.0142
Echinococcus multilocularis beta tubulin 0.0486 0.6585 0.6574
Leishmania major beta tubulin 0.0486 0.6585 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0263 0.3471 0.5248
Trichomonas vaginalis tubulin, putative 0.0114 0.1388 0.2068
Entamoeba histolytica tubulin family protein 0.0486 0.6585 1
Echinococcus granulosus tubulin alpha chain 0.0368 0.4929 0.4912
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0253 0.333 0.5033
Toxoplasma gondii alpha tubulin TUBA1 0.0368 0.4929 0.7485
Toxoplasma gondii beta tubulin 0.0486 0.6585 1
Schistosoma mansoni tubulin subunit beta 0.0114 0.1388 0.136
Echinococcus multilocularis Tubulin beta 2C chain 0.0486 0.6585 0.6574
Loa Loa (eye worm) tubulin alpha-3 chain 0.0219 0.2846 0.4319
Echinococcus granulosus peroxisome assembly protein 26 0.0368 0.4929 0.4912
Plasmodium falciparum tubulin beta chain 0.0486 0.6585 1
Leishmania major beta tubulin 0.0486 0.6585 1
Trichomonas vaginalis tubulin beta chain, putative 0.0149 0.1872 0.2808
Brugia malayi Tubulin alpha-2 chain 0.0368 0.4929 0.7484
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0062 0.0214
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.0485
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.1393 0.4304
Echinococcus granulosus Tubulin alpha 1 chain 0.0368 0.4929 0.4912
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0322 0.0441
Schistosoma mansoni calcium-activated potassium channel 0.0158 0.2003 0.1977
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Brugia malayi hypothetical protein 0.0053 0.0537 0.0811
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0312 0.0469
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0105 0.0155
Echinococcus multilocularis tubulin delta chain 0.0114 0.1388 0.136
Brugia malayi glutathione reductase 0.005 0.0492 0.0743
Echinococcus granulosus tubulin epsilon chain 0.0263 0.3471 0.345
Brugia malayi Tubulin beta-1 chain 0.0486 0.6585 1
Brugia malayi Tubulin alpha chain 0.0114 0.1388 0.2104
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.0485
Onchocerca volvulus 0.0161 0.2036 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0062 0.0214
Echinococcus multilocularis beta tubulin 0.0486 0.6585 0.6574
Brugia malayi Cell division protein ftsZ 0.0114 0.1388 0.2104
Onchocerca volvulus 0.0051 0.0503 0.1703
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.0485
Trichomonas vaginalis tubulin alpha chain, putative 0.0486 0.6585 1
Trypanosoma brucei trypanothione reductase 0.005 0.0492 0.0701
Mycobacterium tuberculosis Conserved protein 0.0038 0.0322 0.0915
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0052 0.0142
Echinococcus granulosus survival motor neuron protein 1 0.025 0.3288 0.3266
Echinococcus granulosus beta tubulin 0.0486 0.6585 0.6574
Schistosoma mansoni ap endonuclease 0.0019 0.0062 0.0029
Brugia malayi Tubulin alpha-2 chain 0.0368 0.4929 0.7484
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.1944 0.1918
Leishmania major cytochrome p450-like protein 0.0037 0.0312 0.0426
Trypanosoma brucei tubulin gamma chain 0.0263 0.3471 0.5248
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Trypanosoma brucei beta tubulin 0.0486 0.6585 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0033 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.0044
Echinococcus multilocularis tubulin alpha chain 0.0368 0.4929 0.4912
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0105 0.011
Schistosoma mansoni hypothetical protein 0.0024 0.0124 0.0092
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0052 0.0142
Loa Loa (eye worm) hypothetical protein 0.0083 0.0956 0.1448
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0188 0.0281
Echinococcus multilocularis tubulin alpha chain 0.0368 0.4929 0.4912
Echinococcus multilocularis tubulin alpha 3 chain 0.0368 0.4929 0.4912
Trichomonas vaginalis tubulin beta chain, putative 0.0368 0.4929 0.7473
Echinococcus multilocularis geminin 0.0355 0.4753 0.4736
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0324 0.0292
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0052 0.0142
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.1393 0.4304
Plasmodium vivax delta tubulin, putative 0.0114 0.1388 0.2104
Onchocerca volvulus 0.0038 0.0322 0.0724
Trypanosoma cruzi zeta tubulin, putative 0.0114 0.1388 0.2068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0058
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0052 0.0061
Schistosoma mansoni tubulin subunit beta 0.0486 0.6585 0.6574
Trichomonas vaginalis tubulin beta chain, putative 0.0368 0.4929 0.7473
Schistosoma mansoni microtubule-associated protein tau 0.073 1 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.1944 0.1918
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0537 0.0769
Echinococcus multilocularis microtubule associated protein 2 0.073 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.0485
Brugia malayi Cytochrome P450 family protein 0.0037 0.0312 0.0469
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.1393 0.8823
Schistosoma mansoni tubulin subunit epsilon 0.0263 0.3471 0.345
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0052 0.0061
Trypanosoma brucei epsilon tubulin 0.0263 0.3471 0.5248
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0062 0.0044
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0324 0.0292
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0322 0.0915
Brugia malayi beta-lactamase family protein 0.0038 0.0322 0.0485
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0124 0.0092
Brugia malayi tubulin alpha chain - mouse 0.0368 0.4929 0.7484
Loa Loa (eye worm) hypothetical protein 0.025 0.3288 0.4991
Echinococcus multilocularis tubulin subunit beta 0.0486 0.6585 0.6574
Echinococcus multilocularis musashi 0.0029 0.0188 0.0156
Brugia malayi Cytochrome P450 family protein 0.0037 0.0312 0.0469
Trichomonas vaginalis tubulin beta chain, putative 0.0368 0.4929 0.7473
Mycobacterium leprae Probable lipase LipE 0.0038 0.0322 0.1776
Toxoplasma gondii ABC1 family protein 0.0038 0.0322 0.0489
Loa Loa (eye worm) alpha-tubulin 0.0368 0.4929 0.7484
Onchocerca volvulus 0.0051 0.0506 0.1721
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0312 0.0426
Schistosoma mansoni intermediate filament proteins 0.0029 0.0188 0.0156
Leishmania major beta tubulin 0.0486 0.6585 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0423 0.0391
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0322 0.0485
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0322 0.0441
Loa Loa (eye worm) hypothetical protein 0.0161 0.2036 0.3088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0062 0.0029
Trypanosoma cruzi tubulin delta chain 0.0114 0.1388 0.2068
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0322 0.0915
Echinococcus multilocularis tubulin alpha chain 0.0368 0.4929 0.4912
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Trypanosoma brucei zeta tubulin 0.0114 0.1388 0.2068
Giardia lamblia Beta tubulin 0.0486 0.6585 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0114 0.1388 1
Leishmania major beta tubulin 0.0486 0.6585 1
Brugia malayi beta-lactamase family protein 0.0038 0.0322 0.0485
Echinococcus granulosus tubulin alpha 1C chain 0.0368 0.4929 0.4912
Schistosoma mansoni lamin 0.0029 0.0188 0.0156
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0052 0.0061
Schistosoma mansoni tubulin subunit beta 0.0486 0.6585 0.6574
Echinococcus granulosus Tubulin alpha 1 chain 0.0368 0.4929 0.4912
Giardia lamblia Beta tubulin 0.0486 0.6585 1
Leishmania major beta tubulin 0.0486 0.6585 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0322 0.029
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0052 0.0142
Trichomonas vaginalis tubulin, putative 0.0149 0.1872 0.2808
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Echinococcus granulosus tubulin alpha chain 0.0368 0.4929 0.4912
Trichomonas vaginalis tubulin beta chain, putative 0.0368 0.4929 0.7473
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0052 0.0029
Entamoeba histolytica hypothetical protein 0.0038 0.0324 0.0402
Toxoplasma gondii exonuclease III APE 0.0019 0.0062 0.0094
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0062 0.0214
Schistosoma mansoni ap endonuclease 0.0019 0.0062 0.0029
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0052 0.0029
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0492 0.0461
Plasmodium vivax tubulin epsilon chain, putative 0.0263 0.3471 0.5269
Giardia lamblia Gamma tubulin 0.0263 0.3471 0.5248
Entamoeba histolytica hypothetical protein 0.0038 0.0324 0.0402
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0188 0.0281
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0052 0.0142
Trichomonas vaginalis tubulin gamma chain, putative 0.0114 0.1388 0.2068
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0052 0.0142
Trypanosoma brucei beta tubulin 0.0263 0.3471 0.5248
Trichomonas vaginalis tubulin gamma chain, putative 0.0263 0.3471 0.5248
Schistosoma mansoni hypothetical protein 0.0019 0.0052 0.0019
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0423 0.0642
Trypanosoma brucei epsilon tubulin 0.0263 0.3471 0.5248
Echinococcus multilocularis Tubulin alpha 1 chain 0.0368 0.4929 0.4912
Loa Loa (eye worm) hypothetical protein 0.0075 0.0836 0.1266
Plasmodium vivax tubulin alpha chain, putative 0.0368 0.4929 0.7484
Schistosoma mansoni hypothetical protein 0.0355 0.4753 0.4736
Loa Loa (eye worm) tubulin alpha 2 0.0253 0.333 0.5055
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0052 0.0142
Brugia malayi intermediate filament protein 0.0029 0.0188 0.0281
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0322 0.029
Mycobacterium ulcerans cell division protein FtsZ 0.0114 0.1388 1
Leishmania major cytochrome p450-like protein 0.0019 0.0052 0.0029
Echinococcus granulosus tubulin gamma 1 chain 0.0263 0.3471 0.345
Trichomonas vaginalis tubulin epsilon chain, putative 0.0114 0.1388 0.2068
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0492 0.0744
Leishmania major delta tubulin, putative 0.0114 0.1388 0.2068
Echinococcus multilocularis lamin 0.0029 0.0188 0.0156
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0537 0.0815
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0506 0.0475
Trichomonas vaginalis tubulin epsilon chain, putative 0.0486 0.6585 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0114 0.1388 0.4288
Treponema pallidum cell division protein FtsZ 0.0114 0.1388 1
Loa Loa (eye worm) tubulin alpha 2 0.0253 0.333 0.5055
Loa Loa (eye worm) cytochrome P450 0.0019 0.0052 0.0075
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0052 0.0029
Schistosoma mansoni tubulin subunit alpha 0.0114 0.1388 0.136
Echinococcus granulosus tubulin alpha 3 chain 0.0368 0.4929 0.4912
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0322 0.0441
Loa Loa (eye worm) hypothetical protein 0.0051 0.0506 0.0765
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0253 0.333 0.5055
Echinococcus granulosus alpha tubulin 0.0368 0.4929 0.4912
Echinococcus granulosus bloom syndrome protein 0.0023 0.0105 0.0072
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0124 0.0092
Echinococcus granulosus Tubulin beta 2C chain 0.0486 0.6585 0.6574
Echinococcus granulosus tubulin alpha 3 chain 0.0368 0.4929 0.4912
Leishmania major beta tubulin 0.0486 0.6585 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0423 0.0642
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.0485
Echinococcus multilocularis peroxisome assembly protein 26 0.0368 0.4929 0.4912
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0062 0.0044
Echinococcus multilocularis lamin dm0 0.0029 0.0188 0.0156
Echinococcus granulosus Tubulin alpha 1 chain 0.0368 0.4929 0.4912
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0322 0.2134
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0322 0.029
Leishmania major beta tubulin 0.0486 0.6585 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0322 0.0441
Loa Loa (eye worm) RecQ helicase 0.0023 0.0105 0.0155
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0322 0.0485
Schistosoma mansoni hypothetical protein 0.0038 0.0324 0.0292
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0033 0.0046
Brugia malayi Thioredoxin reductase 0.005 0.0492 0.0743
Trichomonas vaginalis tubulin beta chain, putative 0.0486 0.6585 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0052 0.0061
Giardia lamblia Epsilon tubulin 0.0114 0.1388 0.2068
Echinococcus multilocularis Tubulin beta 2C chain 0.0486 0.6585 0.6574
Onchocerca volvulus 0.0149 0.1872 0.9116
Schistosoma mansoni hypothetical protein 0.0051 0.0503 0.0472
Plasmodium falciparum tubulin epsilon chain, putative 0.0263 0.3471 0.5248
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0322 0.0915
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0188 0.0281
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0052 0.0061
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0368 0.4929 0.7473
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0052 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1388 0.2068
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.037 0.0473
Echinococcus granulosus beta tubulin 0.0486 0.6585 0.6574
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0062 0.0089
Trichomonas vaginalis tubulin, putative 0.0486 0.6585 1
Plasmodium falciparum alpha tubulin 2 0.0368 0.4929 0.7473
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0038 0.0006
Trichomonas vaginalis esterase, putative 0.0038 0.0322 0.0441
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0322 0.0915
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1388 0.2068
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0052 0.0142
Leishmania major gamma-tubulin 0.0263 0.3471 0.5248
Trypanosoma cruzi epsilon tubulin, putative 0.0263 0.3471 0.5248
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0052 0.0019
Brugia malayi hypothetical protein 0.0038 0.0324 0.0488
Echinococcus multilocularis Tubulin beta 2C chain 0.0486 0.6585 0.6574
Trypanosoma brucei beta tubulin 0.0486 0.6585 1
Trypanosoma cruzi epsilon tubulin, putative 0.0263 0.3471 0.5248
Trypanosoma brucei alpha tubulin 0.0368 0.4929 0.7473
Plasmodium vivax glutathione reductase, putative 0.005 0.0492 0.0744
Loa Loa (eye worm) acetyltransferase 0.0154 0.1944 0.2949
Leishmania major trypanothione reductase 0.005 0.0492 0.0701
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0052 0.0061
Brugia malayi Cytochrome P450 family protein 0.0019 0.0052 0.0075
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0052 0.0061
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0052 0.0142
Mycobacterium tuberculosis Conserved protein 0.0038 0.0322 0.0915
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0312 0.0426
Echinococcus multilocularis hypothetical protein 0.0368 0.4929 0.4912
Brugia malayi cytochrome P450 0.0019 0.0052 0.0075
Brugia malayi hypothetical protein 0.025 0.3288 0.4991
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0322 0.0441
Toxoplasma gondii alpha-tubulin I, putative 0.0368 0.4929 0.7485
Echinococcus multilocularis tubulin alpha chain 0.0368 0.4929 0.4912
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.1393 0.4304
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0312 0.0426
Trypanosoma cruzi beta tubulin, putative 0.0486 0.6585 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0322 0.0915
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.1572 0.487
Echinococcus granulosus lamin 0.0029 0.0188 0.0156
Brugia malayi Cytochrome P450 family protein 0.0059 0.0619 0.0936
Schistosoma mansoni lamin 0.0029 0.0188 0.0156
Onchocerca volvulus 0.0038 0.0322 0.0724
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0492 0.0461
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.3288 0.3266
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0322 0.0485
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0052 0.0029
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Brugia malayi beta-tubulin, identical 0.0486 0.6585 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0052 0.0142
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0052 0.0142
Plasmodium falciparum tubulin gamma chain 0.0263 0.3471 0.5248
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0052 0.0079
Echinococcus multilocularis tubulin alpha chain 0.0368 0.4929 0.4912
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0052 0.0029
Schistosoma mansoni hypothetical protein 0.0355 0.4753 0.4736
Toxoplasma gondii thioredoxin reductase 0.005 0.0492 0.0747
Giardia lamblia Beta tubulin 0.0486 0.6585 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0322 0.2134
Trypanosoma brucei tubulin delta chain 0.0114 0.1388 0.2068
Entamoeba histolytica tubulin alpha chain, putative 0.0368 0.4929 0.7462
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0052 0.0142
Trypanosoma brucei zeta tubulin, putative 0.0114 0.1388 0.2068
Echinococcus granulosus tubulin subunit TubB 0.0368 0.4929 0.4912
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0052 0.0061
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0052 0.0142
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0537 0.0769
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0052 0.0061
Plasmodium falciparum alpha tubulin 1 0.0368 0.4929 0.7473
Schistosoma mansoni tubulin subunit alpha 0.0368 0.4929 0.4912
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0492 0.1454
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0052 0.0142
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0423 0.0595
Echinococcus multilocularis tubulin subunit TubB 0.0368 0.4929 0.4912
Loa Loa (eye worm) BEN-1 protein 0.0486 0.6585 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0033 0.005
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0052 0.0142
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.037 0.0515
Brugia malayi alpha-tubulin 0.0368 0.4929 0.7484
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0114 0.1388 0.2107
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0062 0.0044
Brugia malayi Tubulin gamma chain 0.0263 0.3471 0.5269
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.0044
Echinococcus granulosus Tubulin beta 2C chain 0.0486 0.6585 0.6574
Trichomonas vaginalis tubulin alpha chain, putative 0.0263 0.3471 0.5248
Echinococcus granulosus tubulin alpha chain 0.0368 0.4929 0.4912
Leishmania major epsilon tubulin, putative 0.0263 0.3471 0.5248
Schistosoma mansoni survival motor neuron protein 0.0051 0.0503 0.0472
Leishmania major beta tubulin 0.0486 0.6585 1
Leishmania major beta tubulin 0.0486 0.6585 1
Plasmodium falciparum tubulin delta chain, putative 0.0114 0.1388 0.2068
Giardia lamblia Alpha-tubulin 0.0368 0.4929 0.7473
Entamoeba histolytica tubulin family protein 0.0486 0.6585 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0052 0.0061
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0492 0.0743
Echinococcus granulosus Tubulin beta 2C chain 0.0486 0.6585 0.6574
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0312 0.206
Trichomonas vaginalis tubulin epsilon chain, putative 0.0368 0.4929 0.7473
Trypanosoma cruzi tubulin delta chain 0.0114 0.1388 0.2068
Leishmania major beta tubulin 0.0486 0.6585 1
Loa Loa (eye worm) hypothetical protein 0.0368 0.4929 0.7484
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0105 0.0072
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0062 0.009
Leishmania major beta tubulin 0.0486 0.6585 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0066 0.0052
Plasmodium falciparum thioredoxin reductase 0.005 0.0492 0.0701
Leishmania major alpha tubulin 0.0368 0.4929 0.7473
Schistosoma mansoni tubulin subunit delta 0.0114 0.1388 0.136
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0263 0.3471 0.5271
Trypanosoma brucei alpha tubulin, putative 0.0149 0.1872 0.2808
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0052 0.0061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.3193 1
Leishmania major beta tubulin 0.0486 0.6585 1
Trypanosoma brucei beta tubulin 0.0486 0.6585 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0052 0.0061
Mycobacterium tuberculosis Conserved protein 0.0038 0.0322 0.0915
Schistosoma mansoni calcium-activated potassium channel 0.0166 0.2117 0.2091
Echinococcus multilocularis tubulin alpha 3 chain 0.0368 0.4929 0.4912

Activities

Activity type Activity value Assay description Source Reference
dP/dt (functional) = 43 % Inotropic activity measured as % increase in dP/dt maximum in Anesthetized dog at the dose of 50 microg/Kg administered intravenously ChEMBL. 2845085
Relative potency (functional) = 1.3 Percentage increase in dP/dt maximum observed with 4-[4-[2-(1,1-dioxo-2-isothiazolidinyl)-ethyl]-1-dimethoxyquinazoline (50 microg/Kg) in dog ChEMBL. 2845085

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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