Detailed information for compound 112114

Basic information

Technical information
  • TDR Targets ID: 112114
  • Name: (5Z)-5-[(E)-3-(5-nitrofuran-2-yl)prop-2-enyli dene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • MW: 282.296 | Formula: C10H6N2O4S2
  • H donors: 1 H acceptors: 3 LogP: 2.7 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1NC(=O)/C(=C/C=C/c2ccc(o2)[N+](=O)[O-])/S1
  • InChi: 1S/C10H6N2O4S2/c13-9-7(18-10(17)11-9)3-1-2-6-4-5-8(16-6)12(14)15/h1-5H,(H,11,13,17)/b2-1+,7-3-
  • InChiKey: VGDGBMXDKZEVTF-YDCWOTKKSA-N  


Substructure search Similarity search

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Synonyms

  • (5Z)-5-[(E)-3-(5-nitro-2-furyl)prop-2-enylidene]-2-thioxo-thiazolidin-4-one
  • (5Z)-5-[(E)-3-(5-nitro-2-furyl)prop-2-enylidene]-2-thioxo-4-thiazolidinone
  • 5-[3-(5-nitrofuran-2-yl)prop-2-enylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • 5-[3-(5-nitro-2-furyl)prop-2-enylidene]-2-thioxo-thiazolidin-4-one
  • 5-[3-(5-nitro-2-furyl)prop-2-enylidene]-2-thioxo-4-thiazolidinone
  • P00052
  • (5Z)-5-[(2E)-3-(5-nitro-2-furyl)prop-2-enylidene]-2-thioxo-1,3-thiazolidin-4-one
  • MLS000722913
  • SMR000304908
  • ZINC05172555

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Plasmodium falciparum heat shock protein 90, putative Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens myeloid cell leukemia 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Enterobacter cloacae Beta-lactamase Starlite/ChEMBL References
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens X-box binding protein 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Mus musculus DNA-damage inducible transcript 3 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Human immunodeficiency virus type 1 Tat protein Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase Get druggable targets OG5_131193 All targets in OG5_131193
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase Get druggable targets OG5_131193 All targets in OG5_131193
Echinococcus multilocularis X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii heat shock protein 83 Get druggable targets OG5_144951 All targets in OG5_144951
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134980 All targets in OG5_134980
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii Hsp90 domain-containing protein Get druggable targets OG5_144951 All targets in OG5_144951
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis heat shock protein 90 Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU Get druggable targets OG5_131193 All targets in OG5_131193
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU Get druggable targets OG5_131193 All targets in OG5_131193
Plasmodium vivax heat shock protein, putative Get druggable targets OG5_144951 All targets in OG5_144951
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Echinococcus multilocularis squamous cell carcinoma antigen Human immunodeficiency virus type 1 Tat protein   86 aa 79 aa 30.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0079 0.0633 0.3687
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0123 0.0117
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0178 0.2033
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0178 0.0173
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0062 0.018
Brugia malayi Hsp90 protein 0.0037 0.019 0.1059
Treponema pallidum phosphoglycerate kinase 0.0103 0.0877 0.779
Echinococcus granulosus expressed conserved protein 0.0112 0.097 0.1717
Mycobacterium tuberculosis Conserved protein 0.0043 0.026 0.0367
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.252 0.3631
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0103 0.0877 0.439
Leishmania major DNA polymerase eta, putative 0.0051 0.0335 0.3817
Brugia malayi jmjC domain containing protein 0.003 0.0123 0.0673
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0475 0.4302
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0006 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0062 0.032
Echinococcus multilocularis peregrin 0.0038 0.0204 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Echinococcus granulosus zinc finger protein 0.0024 0.0054 0.0085
Plasmodium vivax endoplasmin, putative 0.0055 0.0384 0.1902
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0178 0.1612
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0103 0.0877 0.439
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0062 0.0328
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.139 0.1385
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.02 0.2283
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0178 0.2033
Plasmodium vivax heat shock protein, putative 0.021 0.199 1
Toxoplasma gondii ABC1 family protein 0.0043 0.026 0.128
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0348 0.365
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Plasmodium falciparum phd finger protein, putative 0.0035 0.0174 0.0846
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.026 0.0367
Echinococcus granulosus heat shock protein 90 0.0047 0.03 0.0525
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0037 0.019 0.0781
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0178 0.2033
Echinococcus multilocularis zinc finger protein 0.0024 0.0054 0.0048
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0015 0.0043
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.026 0.0367
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0684 0.693 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0006 0.0072
Brugia malayi beta-lactamase 0.0043 0.026 0.146
Plasmodium vivax phosphoglycerate kinase, putative 0.0103 0.0877 0.439
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0178 0.1898
Brugia malayi Endoplasmin precursor 0.0055 0.0384 0.2169
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0062 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0328
Onchocerca volvulus 0.0043 0.026 0.1206
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0038 0.02 0.2283
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0022 0.0064
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0062 0.0458 0.2659
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.008 0.0425
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.026 0.2594
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0017
Echinococcus multilocularis thyroid hormone receptor alpha 0.0176 0.1644 0.1639
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0434 0.2518
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1045 0.1851
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0178 0.099
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0178 0.0237
Schistosoma mansoni phosphoglycerate kinase 0.0103 0.0877 0.2559
Brugia malayi Bromodomain containing protein 0.0038 0.0204 0.1137
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0288 0.0502
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0689
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0339 0.1956
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0434 0.246
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0057 0.0153
Brugia malayi Bromodomain containing protein 0.0046 0.0289 0.1626
Echinococcus multilocularis dna polymerase eta 0.0095 0.0795 0.0789
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Schistosoma mansoni apoptosis regulator bax 0.01 0.0849 0.2475
Trypanosoma brucei heat shock protein 84, putative 0.0037 0.019 0.2169
Loa Loa (eye worm) hypothetical protein 0.01 0.0849 0.4953
Schistosoma mansoni hypothetical protein 0.0205 0.1938 0.5651
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0125 0.1419
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0178 0.0868
Plasmodium vivax heat shock protein 86, putative 0.0055 0.0384 0.1902
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0006 0.0072
Brugia malayi jmjC domain containing protein 0.0186 0.1747 1
Plasmodium vivax heat shock protein 90, putative 0.0037 0.019 0.0928
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0186 0.1747 0.1742
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1045 0.104
Echinococcus multilocularis phosphoglycerate kinase 1 0.0103 0.0877 0.0872
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0178 0.0249
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0178 0.2033
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0015 0.0168
Plasmodium falciparum heat shock protein 90, putative 0.0032 0.0143 0.0686
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.03 0.3424
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1308 0.7656
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0884 0.1564
Leishmania major DNA damage repair protein, putative 0.002 0.0015 0.0168
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Onchocerca volvulus Huntingtin homolog 0.0148 0.1348 0.7815
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0475 0.0835
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0044 0.0502
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0236 0.1321
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0123 0.0689
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0022 0.0029
Schistosoma mansoni protein phosphatase 2C 0.003 0.0123 0.0359
Schistosoma mansoni hypothetical protein 0.0043 0.026 0.0758
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.02 0.2283
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0384 0.4372
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.008 0.0425
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0259 0.0254
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0057 0.0153
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.562 0.5617
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0062 0.018
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0809 0.9219
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0178 0.2033
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.2248 0.3238
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.0147 0.0141
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0259 0.0451
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0348 0.3969
Brugia malayi Muscleblind-like protein 0.018 0.1685 0.9645
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0006 0.0072
Trypanosoma brucei phosphoglycerate kinase 0.0103 0.0877 0.9998
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0558 0.0552
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.0849 0.4839
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.252 0.3631
Plasmodium falciparum heat shock protein 90, putative 0.021 0.199 1
Schistosoma mansoni hypothetical protein 0.0035 0.0174 0.0508
Trypanosoma brucei heat shock protein, putative 0.0055 0.0384 0.4372
Onchocerca volvulus Alhambra homolog 0.0035 0.0174 0.0683
Loa Loa (eye worm) endoplasmin 0.0055 0.0384 0.222
Entamoeba histolytica phosphoglycerate kinase, putative 0.0103 0.0877 0.8323
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0022 0.0064
Loa Loa (eye worm) hypothetical protein 0.018 0.1685 0.9872
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0062 0.018
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0348 0.0132
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0123 0.0117
Loa Loa (eye worm) hypothetical protein 0.0043 0.026 0.1495
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.0795 0.9059
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0178 0.0307
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0637 0.3627
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0057 0.0488
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0125 0.1114 0.1589
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0123 0.0209
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0072 0.0558 0.0796
Entamoeba histolytica hypothetical protein 0.0043 0.026 0.2156
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0006 0.0001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0091 0.0085
Loa Loa (eye worm) beta-lactamase 0.0043 0.026 0.1495
Loa Loa (eye worm) glutathione reductase 0.0103 0.0877 0.5124
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0047 0.03 0.0525
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Trypanosoma brucei heat shock protein, putative 0.0055 0.0384 0.4372
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1045 0.5969
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0015 0.0168
Loa Loa (eye worm) hypothetical protein 0.0043 0.026 0.1495
Toxoplasma gondii exonuclease III APE 0.0023 0.0044 0.0191
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.1014 0.2959
Schistosoma mansoni heat shock protein 0.0037 0.019 0.0555
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0143 0.1181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0062 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0809 0.9219
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0062 0.0056
Schistosoma mansoni hypothetical protein 0.0152 0.139 0.4054
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0103 0.0877 0.9998
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0015 0.0168
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2699 0.3889
Chlamydia trachomatis phosphoglycerate kinase 0.0103 0.0877 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0057 0.0299
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0178 0.0868
Echinococcus granulosus X box binding protein 1 0.0348 0.3429 0.6097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0178 0.2033
Onchocerca volvulus 0.0182 0.1707 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.032 0.1845
Echinococcus multilocularis heat shock protein 90 0.0055 0.0384 0.0378
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0125 0.0596
Leishmania major trypanothione reductase 0.0103 0.0877 1
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0877 0.5124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0178 0.2033
Schistosoma mansoni jumonji domain containing protein 0.0163 0.15 0.4376
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0637 0.5927
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0125 0.1114 0.5581
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0349 0.3977
Mycobacterium ulcerans phosphoglycerate kinase 0.0103 0.0877 0.1247
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0062 0.0056
Leishmania major DNA polymerase eta, putative 0.0095 0.0795 0.9059
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.0384 0.1902
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.252 0.3631
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0062 0.0056
Mycobacterium ulcerans hypothetical protein 0.0125 0.1114 0.1589
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.0849 0.2475
Brugia malayi Phosphoglycerate kinase 0.0038 0.02 0.1116
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0335 0.1656
Entamoeba histolytica hypothetical protein 0.0043 0.026 0.2156
Leishmania major phosphoglycerate kinase B, cytosolic 0.0103 0.0877 0.9998
Echinococcus granulosus dna polymerase kappa 0.0096 0.0809 0.143
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0091 0.0266
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0057 0.0153
Schistosoma mansoni hypothetical protein 0.0348 0.3429 1
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0057 0.0255
Trypanosoma brucei phosphoglycerate kinase 0.0038 0.02 0.2283
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0062 0.0099
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1308 0.7656
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0044 0.034
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0384 0.4075
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0328
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.2248 0.3238
Brugia malayi heat shock protein 90 0.0055 0.0384 0.2169
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0637 0.7264
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0015 0.0043
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0057 0.0255
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0062 0.0056
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0044 0.0055
Brugia malayi MH2 domain containing protein 0.0144 0.1308 0.748
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Trypanosoma brucei heat shock protein, putative 0.0055 0.0384 0.4372
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0062 0.0099
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0057 0.0091
Entamoeba histolytica hypothetical protein 0.0043 0.026 0.2156
Toxoplasma gondii thioredoxin reductase 0.0103 0.0877 0.4391
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0017
Brugia malayi PHD-finger family protein 0.003 0.0121 0.066
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0174 0.0846
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0174 0.03
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0877 0.1258
Brugia malayi hypothetical protein 0.0148 0.1348 0.7705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0062 0.0328
Mycobacterium ulcerans beta-lactamase 0.0043 0.026 0.0355
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.2248 0.3238
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0178 0.2033
Giardia lamblia DINP protein human, muc B family 0.0072 0.0558 0.6295
Schistosoma mansoni heat shock protein 0.0055 0.0384 0.1119
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0288 0.0282
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0006 0.0002
Schistosoma mansoni DNA helicase recq5 0.0024 0.0057 0.0166
Brugia malayi steroid hormone receptor 0.0024 0.0062 0.032
Leishmania major DNA polymerase kappa, putative 0.002 0.0015 0.0168
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.0726 0.8274
Echinococcus multilocularis expressed conserved protein 0.0112 0.097 0.0965
Echinococcus granulosus lysine specific demethylase 5A 0.0116 0.1014 0.1796
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0339 0.0333
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Brugia malayi jmjC domain containing protein 0.0116 0.1014 0.5792
Loa Loa (eye worm) hypothetical protein 0.0103 0.0877 0.5122
Echinococcus multilocularis protein dispatched 1 0.0058 0.0414 0.0408
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0057 0.0292
Echinococcus granulosus muscleblind protein 0.018 0.1685 0.2991
Loa Loa (eye worm) hypothetical protein 0.0148 0.1348 0.7887
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0044 0.0038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0328
Loa Loa (eye worm) heat shock protein 90 0.0055 0.0384 0.222
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0123 0.0359
Trypanosoma brucei unspecified product 0.0044 0.0268 0.3051
Echinococcus granulosus geminin 0.0205 0.1938 0.3441
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0558 0.6355
Schistosoma mansoni hypothetical protein 0.0049 0.032 0.0932
Leishmania major phosphoglycerate kinase C, glycosomal 0.0103 0.0877 0.9998
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0062 0.032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0178 0.2033
Brugia malayi beta-lactamase family protein 0.0043 0.026 0.146
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0877 1
Leishmania major hypothetical protein, conserved 0.0043 0.026 0.2966
Echinococcus multilocularis lysine specific demethylase 5A 0.0114 0.099 0.0985
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1064 0.3104
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0689
Loa Loa (eye worm) hypothetical protein 0.0148 0.1348 0.7887
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0062 0.0328
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0328
Leishmania major DNA polymerase kappa, putative 0.0072 0.0558 0.6355
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0057 0.0051
Brugia malayi CHE-14 protein 0.0051 0.0339 0.1911
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0057 0.0647
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0178 0.2033
Loa Loa (eye worm) hypothetical protein 0.006 0.0434 0.2518
Echinococcus multilocularis muscleblind protein 0.018 0.1685 0.168
Plasmodium falciparum phosphoglycerate kinase 0.0103 0.0877 0.439
Plasmodium vivax JmjC domain containing protein 0.003 0.0123 0.0589
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0299
Brugia malayi jmjC domain containing protein 0.003 0.0123 0.0673
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.026 0.0355
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0637 0.1859
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.026 0.2966
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.0147 0.0251
Schistosoma mansoni hypothetical protein 0.0025 0.0067 0.0196
Echinococcus multilocularis protein patched 0.0051 0.0339 0.0333
Trypanosoma brucei unspecified product 0.0088 0.0726 0.8274
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0123 0.0589
Leishmania major heat shock protein, putative 0.0037 0.019 0.2169
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0809 0.1149
Schistosoma mansoni hypothetical protein 0.01 0.0849 0.2475
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0062 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0178 0.2033
Loa Loa (eye worm) hypothetical protein 0.0051 0.0339 0.1956
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0125 0.0596
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0564 0.3283
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0015 0.0043
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0044 0.0191
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0037 0.019 0.1461
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0062 0.032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.1014 0.2959
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0062 0.0328
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0103 0.0877 0.121
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0037 0.019 0.0184
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0103 0.0877 1
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0057 0.0292
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0057 0.0255
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0178 0.0195
Onchocerca volvulus Huntingtin homolog 0.0148 0.1348 0.7815
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.026 0.2594
Echinococcus multilocularis phd:f box containing protein 0.003 0.0123 0.0117
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0178 0.0237
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0049 0.0557
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0809 0.1149
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0475 0.0677
Loa Loa (eye worm) hypothetical protein 0.0043 0.026 0.1495
Schistosoma mansoni phd/f-box containing protein 0.003 0.0123 0.0359
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0123 0.0689
Schistosoma mansoni jumonji domain containing protein 0.003 0.0123 0.0359
Echinococcus multilocularis heat shock protein 0.0055 0.0384 0.0378
Schistosoma mansoni hypothetical protein 0.01 0.0849 0.2475
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.0795 0.4531
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0062 0.032
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.0809 0.918
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0637 0.7264
Loa Loa (eye worm) hypothetical protein 0.0043 0.026 0.1495
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0178 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0351 0.3996
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0434 0.246
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0178 0.2033
Trypanosoma brucei phosphoglycerate kinase, putative 0.0038 0.02 0.2283
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0123 0.0589
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0558 0.0983
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0057 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Schistosoma mansoni DNA helicase recq1 0.0024 0.0057 0.0166
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.02 0.2283
Toxoplasma gondii heat shock protein 75, putative 0.0037 0.019 0.0928
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0062 0.032
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.1114 0.1599
Mycobacterium ulcerans hypothetical protein 0.0043 0.026 0.0355
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0062 0.018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0328
Treponema pallidum NADH oxidase 0.0036 0.0178 0.1256
Brugia malayi hypothetical protein 0.0043 0.026 0.1458
Mycobacterium ulcerans lipase LipD 0.0043 0.026 0.0355
Loa Loa (eye worm) hypothetical protein 0.018 0.1685 0.9872
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0062 0.0328
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0022 0.0064
Trypanosoma brucei phosphoglycerate kinase 0.0103 0.0877 0.9998
Brugia malayi Phosphoglycerate kinase 0.0103 0.0877 0.5004
Echinococcus multilocularis X box binding protein 1 0.0348 0.3429 0.3425
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0174 0.0508
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0348 0.0442
Schistosoma mansoni hypothetical protein 0.01 0.0849 0.2475
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0384 0.4372
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.0384 0.4372
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.2248 0.3238
Onchocerca volvulus 0.0043 0.026 0.1206
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.026 0.0367
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.026 0.0759
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0178 0.0237
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0044 0.0068
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0057 0.0127
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.026 0.2594
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0062 0.018
Loa Loa (eye worm) hypothetical protein 0.0095 0.0795 0.4638
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0015 0.0168
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0178 0.2033
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.026 0.0367
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.003 0.014
Brugia malayi hypothetical protein 0.0182 0.1707 0.977
Giardia lamblia PHD finger protein 15 0.0035 0.0174 0.1848
Brugia malayi ecdysteroid receptor 0.0024 0.0062 0.032
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0062 0.018
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0057 0.0647
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0348 0.0482
Entamoeba histolytica hypothetical protein 0.0043 0.026 0.2156
Loa Loa (eye worm) hypothetical protein 0.0052 0.0349 0.2016
Schistosoma mansoni hypothetical protein 0.0041 0.0236 0.0688
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.0384 0.4372
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0123 0.1403
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0178 0.2033
Plasmodium falciparum heat shock protein 90 0.0055 0.0384 0.1902
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0062 0.018
Schistosoma mansoni phosphoglycerate kinase 0.0103 0.0877 0.2559
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0015 0.0168
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0123 0.0689
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.0384 0.4277
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0318 0.0312
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0178 0.2033
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0006 0.0018
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0339 0.0593
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1576 0.2797
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0062 0.0099
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.1353
Giardia lamblia Phosphoglycerate kinase 0.0103 0.0877 1
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0015 0.0168
Echinococcus granulosus phd:f box containing protein 0.003 0.0123 0.0209
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.026 0.0367
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0178 0.0868
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0125 0.0596
Brugia malayi jmjC domain containing protein 0.003 0.0123 0.0673
Trypanosoma brucei unspecified product 0.0044 0.0268 0.3051
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0174 0.0168
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0125 0.1419
Brugia malayi hypothetical protein 0.003 0.0125 0.0681
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.026 0.2594
Brugia malayi nuclear receptor NHR-88 0.0024 0.0062 0.032
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0062 0.032
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.026 0.2966
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0339 0.3536
Mycobacterium tuberculosis Conserved protein 0.0043 0.026 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0062 0.032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0062 0.032
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0178 0.0868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0062 0.0328
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.026 0.0453
Trypanosoma brucei heat shock protein, putative 0.0055 0.0384 0.4372
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0123 0.0589
Schistosoma mansoni zinc finger protein 0.0024 0.0054 0.0157
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.026 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0351 0.3996
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0062 0.032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0062 0.0099
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.026 0.2966
Schistosoma mansoni heat shock protein 0.0055 0.0384 0.1119
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0637 0.0632
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.026 0.2594
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0062 0.032
Mycobacterium tuberculosis Probable reductase 0.0234 0.2248 0.3238
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0044 0.0224
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0328
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0475 0.2756
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0015 0.0168
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0475 0.1385
Schistosoma mansoni coup transcription factor 0.0024 0.0062 0.018
Echinococcus granulosus dna polymerase eta 0.0095 0.0795 0.1405
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0062 0.032
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0178 0.1612
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.0989
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.693 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0884 0.0878
Trypanosoma cruzi heat shock protein, putative 0.0037 0.019 0.2169
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0176 0.1644 0.4795
Toxoplasma gondii Hsp90 domain-containing protein 0.021 0.199 1
Brugia malayi glutathione reductase 0.0103 0.0877 0.5005
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.03 0.3424
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0328
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.026 0.0758
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0174 0.0846
Brugia malayi hypothetical protein 0.002 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0062 0.032
Echinococcus granulosus heat shock protein 90 0.0055 0.0384 0.0673
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0022 0.0016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0475 0.0469
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0335 0.3817
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.03 0.3312
Brugia malayi PHD-finger family protein 0.0035 0.0174 0.0966
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.0098 0.0461
Brugia malayi jmjC domain containing protein 0.003 0.0123 0.0673
Trypanosoma brucei trypanothione reductase 0.0103 0.0877 1
Brugia malayi beta-lactamase family protein 0.0043 0.026 0.146
Brugia malayi Bromodomain containing protein 0.0091 0.075 0.4275
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0328
Brugia malayi nuclear hormone receptor 0.0024 0.0062 0.032
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0072 0.0558 0.6355
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0125 0.0596
Loa Loa (eye worm) hypothetical protein 0.0043 0.026 0.1495
Loa Loa (eye worm) hypothetical protein 0.0052 0.0344 0.1986
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0103 0.0877 1
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0067 0.0359
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1576 0.1571
Leishmania major hypothetical protein, conserved 0.003 0.0123 0.1403
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0062 0.0099
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0877 0.4391
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Trypanosoma brucei heat shock protein, putative 0.0055 0.0384 0.4372
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0103 0.0877 0.0925
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0038 0.02 0.2283
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0637 0.7264
Trichomonas vaginalis endoplasmin, putative 0.004 0.0226 0.218
Schistosoma mansoni hypothetical protein 0.0049 0.032 0.0932
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0062 0.0056
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.0384 0.3392
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0178 0.2033
Echinococcus granulosus phosphoglycerate kinase 1 0.0103 0.0877 0.1552
Schistosoma mansoni patched 1 0.0051 0.0339 0.0988
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0637 0.7264
Echinococcus granulosus endoplasmin 0.0052 0.0348 0.061
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0062 0.032
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.2248 0.3238
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0339 0.0593
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0123 0.1403
Loa Loa (eye worm) hypothetical protein 0.0085 0.0697 0.406
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0057 0.0255
Giardia lamblia Grp94/Hsp90 0.0052 0.0348 0.3867
Loa Loa (eye worm) hypothetical protein 0.0182 0.1707 1
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0123 0.0209
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0062 0.018
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.026 0.0759
Schistosoma mansoni hypothetical protein 0.0049 0.032 0.0932
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0384 0.4372
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0123 0.0209
Plasmodium falciparum glutathione reductase 0.0103 0.0877 0.4391
Leishmania major hypothetical protein, conserved 0.003 0.0125 0.1419
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0057 0.0091
Schistosoma mansoni DNA polymerase eta 0.0095 0.0795 0.2318
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0044 0.0502
Loa Loa (eye worm) hypothetical protein 0.0046 0.029 0.167
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.026 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0062 0.0328
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0006 0.0072
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0062 0.0099
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0178 0.0868
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.562 1
Schistosoma mansoni endoplasmin 0.0055 0.0384 0.1119
Schistosoma mansoni bromodomain containing protein 0.0076 0.0603 0.1759
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0637 0.1125
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0475 0.2692
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.026 0.0254
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0022 0.0029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.026 0.0452
Schistosoma mansoni endoplasmin 0.0055 0.0384 0.1119
Mycobacterium ulcerans hypothetical protein 0.0125 0.1114 0.1589
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0038 0.02 0.2283
Echinococcus multilocularis dna polymerase kappa 0.0096 0.0809 0.0804
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0017
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0044 0.0219
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0015 0.0168
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.026 0.1495
Plasmodium vivax glutathione reductase, putative 0.0103 0.0877 0.4391
Echinococcus multilocularis heat shock protein 90 0.0047 0.03 0.0295
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.562 0.5617
Trypanosoma brucei heat shock protein, putative 0.0055 0.0384 0.4372
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.0849 0.1501
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0022 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0174 0.0846
Echinococcus granulosus bloom syndrome protein 0.0024 0.0057 0.0091
Trichomonas vaginalis esterase, putative 0.0043 0.026 0.2594
Schistosoma mansoni hypothetical protein 0.0205 0.1938 0.5651
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0015 0.0168
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0062 0.018
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0178 0.052
Echinococcus granulosus neuropeptide s receptor 0.0558 0.562 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.026 0.146
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0318 0.0555
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0015 0.0043
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0044 0.0042
Onchocerca volvulus 0.0043 0.026 0.1206
Loa Loa (eye worm) jmjC domain-containing protein 0.0116 0.1014 0.5929
Loa Loa (eye worm) heat shock protein 75 0.0037 0.019 0.1084
Schistosoma mansoni ap endonuclease 0.0023 0.0044 0.0129
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0044 0.0502
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0091 0.0152
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Trichomonas vaginalis heat shock protein, putative 0.004 0.0226 0.218
Echinococcus multilocularis endoplasmin 0.0052 0.0348 0.0342
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.1114 0.1599
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.139 0.2465
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0125 0.1419
Echinococcus granulosus peregrin 0.0038 0.0204 0.0353
Plasmodium falciparum thioredoxin reductase 0.0036 0.0178 0.0868
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.0384 0.4372
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0022 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0176 0.1644 0.4795
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0103 0.0877 0.9998
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1045 1
Treponema pallidum licC protein (licC) 0.0125 0.1114 1
Plasmodium falciparum thioredoxin reductase 0.0103 0.0877 0.4391
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0475 0.1385
Echinococcus multilocularis muscleblind protein 1 0.018 0.1685 0.168
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0351 0.3996
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.026 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0062 0.0328
Loa Loa (eye worm) hypothetical protein 0.0119 0.1045 0.6109
Trichomonas vaginalis heat shock protein, putative 0.0047 0.03 0.3077
Brugia malayi polk-prov protein 0.0052 0.0349 0.197
Plasmodium vivax hypothetical protein, conserved 0.0043 0.026 0.128
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0062 0.032
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.0384 0.4372
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0062 0.0099
Treponema pallidum heat shock protein 90 0.0052 0.0348 0.2844
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0849 0.0843
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0037 0.019 0.0328
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0062 0.0099
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0123 0.1403
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0062 0.0056
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0174 0.0989
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0103 0.0877 0.1258
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0044 0.0502
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0123 0.0117
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0186 0.1747 0.3101
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.252 0.3389
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.0384 0.4372
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0178 0.0868
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.0849 0.0843
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.0849 0.4953
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0348 0.0494
Plasmodium falciparum endoplasmin, putative 0.004 0.0226 0.1106
Loa Loa (eye worm) RecQ helicase 0.0024 0.0057 0.0299
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0348 0.365
Echinococcus granulosus heat shock protein 0.0055 0.0384 0.0673
Leishmania major heat shock protein 83-1 0.0055 0.0384 0.4372
Brugia malayi Thioredoxin reductase 0.0103 0.0877 0.5005
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.0795 0.9059
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0349 0.3977
Mycobacterium tuberculosis Conserved protein 0.0043 0.026 0.0367
Toxoplasma gondii heat shock protein HSP90 0.0055 0.0384 0.1902
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.0809 0.918
Loa Loa (eye worm) hypothetical protein 0.003 0.0125 0.0697
Plasmodium falciparum glutathione reductase 0.0036 0.0178 0.0868
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0178 0.2033
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0637 0.3712
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0062 0.0099
Trypanosoma brucei heat shock protein, putative 0.0055 0.0384 0.4372
Brugia malayi isocitrate dehydrogenase 0.0019 0.0006 0.0002
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0057 0.0647
Schistosoma mansoni hypothetical protein 0.0049 0.032 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0062 0.032
Loa Loa (eye worm) hypothetical protein 0.0043 0.026 0.1495
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.693 1
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.0384 0.3392
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0044 0.0191
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0684 0.693 1
Trypanosoma brucei heat shock protein, putative 0.0055 0.0384 0.4372
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0123 0.0359
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.026 0.0367
Echinococcus multilocularis geminin 0.0205 0.1938 0.1933
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0057 0.0051
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0849 0.1501
Schistosoma mansoni ap endonuclease 0.0023 0.0044 0.0129
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.2248 0.298
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0006 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0809 0.9219
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0062 0.032

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 1.731 uM PUBCHEM_BIOASSAY: HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 2.45 uM PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 12.502 uM PUBCHEM_BIOASSAY: 24 hour HeLa Cytotox assay Measured in Cell-Based System Using Plate Reader - 2117-03_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
AC50 (binding) = 71.417 uM PUBCHEM_BIOASSAY: C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
IC50 (binding) = 0.45 uM Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacae ChEMBL. 11012024
IC50 (binding) = 0.45 uM Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacae ChEMBL. 11012024
IC50 (functional) = 1.920964755 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] ChEMBL. No reference
IC50 (functional) 2.759 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 9.29 uM PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (functional) > 9.63 uM PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (binding) = 19.07 um PUBCHEM_BIOASSAY: Inhibitors of Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU). Secondary screen. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 37.73 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 40.212 uM PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493244, AID504337, AID504635] ChEMBL. No reference
IC50 (functional) > 94.096 uM PubChem BioAssay. Counterscreen for inhibitors of T-cell receptor (TCR)-CD3 interaction: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 100 uM Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli ChEMBL. 11012024
IC50 (binding) = 100 uM Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli ChEMBL. 11012024
IC50 (binding) 122.468 uM PubChem BioAssay. Counterscreen for inhibitors of phospholipase C isozymes (PLC-B3): Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) 122.468 uM PubChem BioAssay. Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-B3). (Class of assay: confirmatory) ChEMBL. No reference
MIC (functional) = 2 ug ml-1 The compound was evaluated for antimicrobial activity against Escherichia coli OC 4075 by inhibiting enzyme TEM-1 ChEMBL. 11012024
MIC (functional) = 2 ug ml-1 The compound was evaluated for antimicrobial activity against Enterobacter cloacae OC 4080 by inhibiting enzyme P99 ChEMBL. 11012024
MIC (functional) = 2 ug ml-1 The compound was evaluated for antimicrobial activity against Escherichia coli OC 4075 by inhibiting enzyme TEM-1 ChEMBL. 11012024
MIC (functional) = 8 ug ml-1 The compound was evaluated for antimicrobial activity against S. marcescens OC 4101 by inhibiting enzyme AmpC(ind) ChEMBL. 11012024
MIC (functional) = 8 ug ml-1 The compound was evaluated for antimicrobial activity against S. marcescens OC 4294 by inhibiting enzyme AmpC(const) ChEMBL. 11012024
MIC (functional) = 32 ug ml-1 The compound was evaluated for antimicrobial activity against P. aeruginosa OC 4270 by inhibiting enzyme AmpC(ind) ChEMBL. 11012024
MIC (functional) = 32 ug ml-1 The compound was evaluated for antimicrobial activity against P. aeruginosa OC 4290 by inhibiting enzyme AmpC(const) ChEMBL. 11012024
MIC (functional) = 32 ug ml-1 The compound was evaluated for antimicrobial activity against Enterobacter cloacae OC 4092 by inhibiting enzyme E2 (ind) ChEMBL. 11012024
MIC (functional) = 32 ug ml-1 The compound was evaluated for antimicrobial activity against Enterobacter cloacae OC 4081 by inhibiting enzyme E2 (const) ChEMBL. 11012024
Potency (functional) 0.2936 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.2936 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.3256 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.631 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.6513 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 2.5902 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6679 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2629 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 3.2885 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.7444 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.7755 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2549 (qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 58.4789 uM PubChem BioAssay. qHTS for Inhibitors of Cell Surface uPA Generation: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Ratio (functional) NA 0 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against Escherichia coli OC 4075 by inhibiting enzyme TEM-1 at 4 ug/mL; not applicable ChEMBL. 11012024
Ratio (functional) NA 0 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against Enterobacter cloacae OC 4080 by inhibiting enzyme P99 at 4 ug/mL; not applicable ChEMBL. 11012024
Ratio (functional) = 2 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against S. marcescens OC 4101 by inhibiting enzyme AmpC(ind) at 1 ug/mL ChEMBL. 11012024
Ratio (functional) = 2 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against S. marcescens OC 4101 by inhibiting enzyme AmpC(ind) at 4 ug/mL ChEMBL. 11012024
Ratio (functional) = 4 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against P. aeruginosa OC 4270 by inhibiting enzyme AmpC(ind) at 1 ug/mL ChEMBL. 11012024
Ratio (functional) = 4 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against P. aeruginosa OC 4270 by inhibiting enzyme AmpC(ind) at 4 ug/mL ChEMBL. 11012024
Ratio (functional) = 8 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against S. marcescens OC 4294 by inhibiting enzyme AmpC(const) at 4 ug/mL ChEMBL. 11012024
Ratio (functional) = 8 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against P. aeruginosa OC 4290 by inhibiting enzyme AmpC(const) at 4 ug/mL ChEMBL. 11012024
Ratio (functional) = 16 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against P. aeruginosa OC 4290 by inhibiting enzyme AmpC(const) at 1 ug/mL ChEMBL. 11012024
Ratio (functional) = 32 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against S. marcescens OC 4294 by inhibiting enzyme AmpC(const) at 1 ug/mL ChEMBL. 11012024
Ratio (functional) = 64 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against Escherichia coli OC 4075 by inhibiting enzyme TEM-1 at 1 ug/mL ChEMBL. 11012024
Ratio (functional) = 64 The ratio of compound to that of piperacillin was evaluated for antimicrobial activity against Enterobacter cloacae OC 4080 by inhibiting enzyme P99 at 1 ug/mL ChEMBL. 11012024

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23
Giardia lamblia

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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