Detailed information for compound 1159190

Basic information

Technical information
  • TDR Targets ID: 1159190
  • Name: methyl (1R,2S)-2-[(4-hydroxy-4-phenylpiperidi n-1-yl)methyl]-1-(4-methylphenyl)cyclopropane -1-carboxylate
  • MW: 379.492 | Formula: C24H29NO3
  • H donors: 1 H acceptors: 2 LogP: 3.51 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@@]1(C[C@@H]1CN1CCC(CC1)(O)c1ccccc1)c1ccc(cc1)C
  • InChi: 1S/C24H29NO3/c1-18-8-10-20(11-9-18)24(22(26)28-2)16-21(24)17-25-14-12-23(27,13-15-25)19-6-4-3-5-7-19/h3-11,21,27H,12-17H2,1-2H3/t21-,24+/m1/s1
  • InChiKey: BDSYECBSUUOPCT-QPPBQGQZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (1R,2S)-2-[(4-hydroxy-4-phenyl-1-piperidyl)methyl]-1-(4-methylphenyl)cyclopropane-1-carboxylate
  • (1R,2S)-2-[(4-hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-1-cyclopropanecarboxylic acid methyl ester
  • (1R,2S)-2-[(4-hydroxy-4-phenyl-1-piperidyl)methyl]-1-(4-methylphenyl)cyclopropane-1-carboxylic acid methyl ester
  • methyl (1R,2S)-2-[(4-hydroxy-4-phenyl-piperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropane-1-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Sigma-1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0031 0.0059 0.0057
Schistosoma mansoni smad1 5 8 and 0.0018 0.0012 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0098 0.0096
Echinococcus multilocularis serotonin receptor 0.0042 0.0098 0.0096
Trichomonas vaginalis esterase, putative 0.0042 0.0098 0.0218
Trypanosoma brucei alpha tubulin 0.0847 0.2985 0.7497
Echinococcus granulosus g protein coupled receptor 0.0042 0.0098 0.0096
Schistosoma mansoni neuropeptide receptor 0.0042 0.0098 0.0096
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0292 0.029
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0223 0.5012
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0243 0.0821 0.8262
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0059 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0133 0.0305
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0012 0.0029
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0098 0.0711
Toxoplasma gondii ABC1 family protein 0.0042 0.0098 0.0218
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0063 0.0158
Onchocerca volvulus Huntingtin homolog 0.0125 0.0395 0.3346
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0038 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0221 0.0526
Brugia malayi Tubulin gamma chain 0.0691 0.2425 0.6098
Trichomonas vaginalis tubulin epsilon chain, putative 0.029 0.0987 0.246
Schistosoma mansoni hypothetical protein 0.0047 0.0117 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.004 0.007
Trichomonas vaginalis tubulin alpha chain, putative 0.0342 0.1175 0.2934
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0098 0.0096
Echinococcus granulosus beta tubulin 0.1124 0.3977 0.3976
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0117 0.0295
Mycobacterium ulcerans lipase LipD 0.0042 0.0098 0.0711
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0036 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0063 0.0128
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0002 0.0005
Echinococcus multilocularis cpg binding protein 0.0031 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0227 0.0763 0.1918
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0223 0.2015
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0059 0.0057
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0046
Brugia malayi sulfakinin receptor protein 0.0042 0.0098 0.0247
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0051 0.0132 0.1057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0203 0.0481
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0132 0.1057
Schistosoma mansoni amine GPCR 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0248
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0098 0.0096
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0063 0.0128
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0015 0.0002 0.0005
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0013 0.0032
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0223 0.2015
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0292 0.0707
Onchocerca volvulus 0.0042 0.0098 0.0819
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0067 0.0065
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0059 0.0057
Echinococcus granulosus tubulin subunit TubB 0.0847 0.2985 0.2983
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0132 0.1057
Plasmodium vivax tubulin alpha chain, putative 0.0847 0.2985 0.7498
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0051 0.0132 0.1057
Echinococcus multilocularis GPCR, family 2 0.0047 0.0117 0.0115
Loa Loa (eye worm) tubulin alpha chain 0.0847 0.2985 0.7505
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0098 0.0096
Trichomonas vaginalis tubulin, putative 0.0349 0.1198 0.299
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0098 0.0096
Schistosoma mansoni sodium/chloride dependent transporter 0.0182 0.0602 0.06
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0067 0.0139
Loa Loa (eye worm) hypothetical protein 0.0149 0.0483 0.1214
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0243 0.0821 0.8247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0002
Leishmania major delta tubulin, putative 0.0652 0.2287 0.5738
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Schistosoma mansoni ran 0.0021 0.0023 0.0021
Brugia malayi Probable ClpP-like protease 0.0077 0.0223 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0021
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0096 0.0291 0.0703
Plasmodium vivax tubulin beta chain, putative 0.1124 0.3977 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0015 0.0002 0.0005
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0098 0.0096
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0067 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0174 0.0573 0.5673
Loa Loa (eye worm) tubulin alpha-3 chain 0.0505 0.1757 0.4419
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0023 0.0027
Mycobacterium tuberculosis Probable reductase 0.0219 0.0733 0.7346
Brugia malayi tubulin alpha-2 chain 0.0847 0.2985 0.7505
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0174 0.0573 0.1441
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0069 0.0405
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0002 0.0005
Leishmania major beta tubulin 0.1124 0.3977 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0059 0.0057
Echinococcus multilocularis tubulin alpha 3 chain 0.0847 0.2985 0.2983
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0098 0.0096
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.013 0.0415 0.4021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0002
Onchocerca volvulus 0.0027 0.0045 0.0367
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0098 0.0247
Loa Loa (eye worm) hypothetical protein 0.0157 0.0511 0.1284
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0015 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0102 0.0314 0.0312
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0069 0.0067
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0015 0.0002 0.0005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0059 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0098 0.0218
Trypanosoma brucei alpha tubulin 0.0847 0.2985 0.7497
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0067 0.0139
Brugia malayi MH1 domain containing protein 0.0018 0.0012 0.0029
Trypanosoma brucei tubulin gamma chain 0.0691 0.2425 0.6085
Schistosoma mansoni microtubule-associated protein tau 0.2804 1 1
Toxoplasma gondii hypothetical protein 0.0031 0.0059 0.0119
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Echinococcus multilocularis Tubulin beta 2C chain 0.1124 0.3977 0.3976
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Echinococcus granulosus tubulin gamma 1 chain 0.0691 0.2425 0.2424
Trypanosoma brucei beta tubulin 0.1124 0.3977 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis lamin 0.0027 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0182 0.0602 0.1514
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0223 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0063 0.0128
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0098 0.0096
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0031 0.0059 0.0057
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0096 0.0291 0.0289
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0098 0.0096
Trypanosoma brucei beta tubulin 0.1124 0.3977 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Leishmania major beta tubulin 0.1124 0.3977 1
Echinococcus granulosus tm gpcr rhodopsin 0.1042 0.3683 0.3682
Loa Loa (eye worm) hypothetical protein 0.013 0.0415 0.1044
Echinococcus multilocularis tubulin alpha chain 0.0847 0.2985 0.2983
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0098 0.0247
Loa Loa (eye worm) phosphatidylinositol 3 0.0096 0.0291 0.0731
Plasmodium falciparum thioredoxin reductase 0.0033 0.0067 0.0139
Loa Loa (eye worm) ctsf protein 0.0018 0.0012 0.003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0268 0.0909 0.9186
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0213 0.0211
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0223 0.0533
Trypanosoma brucei beta tubulin 0.1124 0.3977 1
Schistosoma mansoni tubulin subunit epsilon 0.069 0.2422 0.2421
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.0027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0098 0.0096
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0098 0.0096
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0032
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0248
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0063 0.0128
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0015 0.0002 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0483 0.1214
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0096 0.0291 0.0701
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0067 0.0307
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0012 0.001
Leishmania major beta tubulin 0.1124 0.3977 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0053 0.0133
Onchocerca volvulus 0.0042 0.0098 0.0819
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0096
Schistosoma mansoni tubulin subunit beta 0.1124 0.3977 0.3976
Trypanosoma brucei zeta tubulin 0.0896 0.316 0.794
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0067 0.0139
Toxoplasma gondii beta tubulin 0.1124 0.3977 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0069 0.0142
Trypanosoma cruzi tubulin delta chain 0.0652 0.2287 0.5738
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0098 0.0819
Schistosoma mansoni opsin-like receptor 0.0042 0.0098 0.0096
Brugia malayi RE15519p 0.0042 0.0098 0.0247
Echinococcus granulosus tubulin alpha 1C chain 0.0847 0.2985 0.2983
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0098 0.0096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0013 0.0032
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0051 0.0132 0.1057
Echinococcus multilocularis tubulin alpha chain 0.0847 0.2985 0.2983
Schistosoma mansoni single-minded 0.0052 0.0134 0.0132
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0098 0.0096
Giardia lamblia Beta tubulin 0.1124 0.3977 1
Plasmodium vivax delta tubulin, putative 0.029 0.0987 0.246
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0098 0.0096
Trichomonas vaginalis tubulin, putative 0.0342 0.1175 0.2934
Loa Loa (eye worm) hypothetical protein 0.0174 0.0573 0.1441
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0098 0.0096
Mycobacterium tuberculosis Probable oxidoreductase 0.0243 0.0821 0.8262
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0013 0.0011
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0069 0.0067
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0117 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Trichomonas vaginalis tubulin gamma chain, putative 0.1124 0.3977 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0051 0.0132 0.1057
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0098 0.0096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0296 0.0745
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0067 0.0385
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0045 0.0113
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0059 0.0119
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0098 0.0247
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0063 0.0061
Brugia malayi Tubulin alpha-2 chain 0.0847 0.2985 0.7505
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0015 0.0002 0.0005
Echinococcus granulosus nmda type glutamate receptor 0.0032 0.0063 0.0061
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0098 0.0096
Brugia malayi G protein-coupled receptor 0.0042 0.0098 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0213 0.0211
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0223 0.0533
Brugia malayi AMP-binding enzyme family protein 0.0174 0.0573 0.1441
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0098 0.0096
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0557 0.1946 0.4892
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0098 0.0096
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.1542 0.3859
Mycobacterium tuberculosis Conserved protein 0.0042 0.0098 0.0711
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.013 0.0415 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0051 0.0132 0.03
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0069 0.0067
Leishmania major beta tubulin 0.1124 0.3977 1
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0132 0.0331
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0098 0.0711
Trichomonas vaginalis tubulin alpha chain, putative 0.0632 0.2215 0.5555
Trichomonas vaginalis tubulin beta chain, putative 0.0342 0.1175 0.2934
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0048 0.0121
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0182 0.0602 0.06
Onchocerca volvulus 0.0051 0.0132 0.1105
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0012 0.001
Leishmania major epsilon tubulin, putative 0.069 0.2422 0.6078
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0048 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0291 0.0703
Brugia malayi Tubulin alpha chain 0.029 0.0987 0.2483
Trypanosoma cruzi beta tubulin, putative 0.1124 0.3977 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0174 0.0573 0.5673
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0067 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0151 0.035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0296 0.0294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Echinococcus multilocularis Tubulin beta 2C chain 0.1124 0.3977 0.3976
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0847 0.2985 0.7498
Trichomonas vaginalis antibiotic synthetase, putative 0.0051 0.0132 0.0301
Loa Loa (eye worm) hypothetical protein 0.0051 0.0132 0.0331
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0296 0.0294
Schistosoma mansoni alpha tubulin 0.0847 0.2985 0.2983
Echinococcus multilocularis tubulin alpha chain 0.0847 0.2985 0.2983
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Schistosoma mansoni opsin-like receptor 0.0042 0.0098 0.0096
Schistosoma mansoni tubulin subunit gamma 0.0691 0.2425 0.2424
Onchocerca volvulus 0.0042 0.0098 0.0819
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0067 0.0139
Schistosoma mansoni amine GPCR 0.0042 0.0098 0.0096
Leishmania major beta tubulin 0.1124 0.3977 1
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0096
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0223 0.5012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0098 0.0096
Echinococcus multilocularis Tubulin beta 2C chain 0.1124 0.3977 0.3976
Mycobacterium ulcerans acyl-CoA synthetase 0.0174 0.0573 0.5673
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0098 0.0096
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Loa Loa (eye worm) tubulin beta chain 0.029 0.0987 0.2483
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0051 0.0132 0.1057
Brugia malayi hypothetical protein 0.0125 0.0395 0.0992
Plasmodium vivax tubulin alpha chain, putative 0.0847 0.2985 0.7498
Brugia malayi Smad1 0.0018 0.0012 0.0029
Loa Loa (eye worm) alpha-tubulin 0.0847 0.2985 0.7505
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0223 0.0221
Echinococcus multilocularis beta tubulin 0.1124 0.3977 0.3976
Onchocerca volvulus 0.0174 0.0573 0.4869
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0051 0.0132 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0132 0.0985
Echinococcus granulosus tumor protein p63 0.1073 0.3793 0.3792
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0182 0.0602 0.1514
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0059 0.0119
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0213 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.029 0.0987 0.246
Loa Loa (eye worm) hypothetical protein 0.0125 0.0395 0.0992
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0038 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Loa Loa (eye worm) serotonin transporter b 0.0182 0.0602 0.1514
Brugia malayi hypothetical protein 0.0077 0.0224 0.0563
Loa Loa (eye worm) Smad1 0.0018 0.0012 0.0029
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0043 0.013
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0098 0.0096
Echinococcus granulosus dnaJ subfamily B 0.0416 0.1439 0.1437
Toxoplasma gondii thioredoxin reductase 0.0096 0.0292 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0291 0.0703
Schistosoma mansoni lamin 0.0027 0.0045 0.0043
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0292 0.0707
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0059 0.0149
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0292 0.2737
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0002 0.0005
Onchocerca volvulus 0.0157 0.0511 0.4337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0296 0.0294
Leishmania major GTP-binding protein, putative 0.0021 0.0023 0.0027
Schistosoma mansoni alpha tubulin 0.0847 0.2985 0.2983
Brugia malayi MH1 domain containing protein 0.0018 0.0012 0.0029
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0051 0.0132 0.0301
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0012 0.001
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0038 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0123 0.039 0.3755
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0117 0.0295
Trichomonas vaginalis tubulin beta chain, putative 0.0847 0.2985 0.7498
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0069 0.0142
Echinococcus granulosus Tubulin beta 2C chain 0.1124 0.3977 0.3976
Plasmodium vivax tubulin epsilon chain, putative 0.069 0.2422 0.6078
Leishmania major beta tubulin 0.1124 0.3977 1
Schistosoma mansoni tubulin subunit beta 0.1124 0.3977 0.3976
Echinococcus multilocularis Tubulin alpha 1 chain 0.0847 0.2985 0.2983
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0098 0.0247
Echinococcus granulosus tubulin alpha 0.0632 0.2215 0.2213
Echinococcus multilocularis Tubulin beta 2C chain 0.1124 0.3977 0.3976
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0098 0.0247
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0149
Echinococcus multilocularis cysteine protease 0.0018 0.0012 0.001
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0051 0.0132 0.1057
Trichomonas vaginalis tubulin beta chain, putative 0.1124 0.3977 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0296 0.0294
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0098 0.0636
Schistosoma mansoni histamine h1 receptor 0.0042 0.0098 0.0096
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0051 0.0132 0.1057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Trichomonas vaginalis tubulin epsilon chain, putative 0.0847 0.2985 0.7498
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0067 0.0139
Entamoeba histolytica hypothetical protein 0.0077 0.0224 0.0534
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Echinococcus multilocularis tubulin subunit TubB 0.0847 0.2985 0.2983
Schistosoma mansoni adenoreceptor 0.0042 0.0098 0.0096
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0098 0.0096
Schistosoma mansoni smad1 5 8 and 0.0018 0.0012 0.001
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis smad 0.0018 0.0012 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0002 0.0005
Toxoplasma gondii FATC domain-containing protein 0.0018 0.0013 0.0002
Treponema pallidum NADH oxidase 0.0033 0.0067 0.0385
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0002 0.0005
Echinococcus granulosus lamin dm0 0.0027 0.0045 0.0043
Schistosoma mansoni glutaminase 0.0273 0.0926 0.0924
Loa Loa (eye worm) hypothetical protein 0.0089 0.0268 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0178 0.0418
Toxoplasma gondii target of rapamycin (TOR), putative 0.0071 0.0203 0.0481
Plasmodium vivax importin-beta 2, putative 0.0028 0.0049 0.0094
Loa Loa (eye worm) hypothetical protein 0.0047 0.0117 0.0295
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0048 0.009
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0051 0.0132 0.0985
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Brugia malayi Melatonin receptor type 1A 0.0042 0.0098 0.0247
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.003
Schistosoma mansoni tubulin subunit alpha 0.0847 0.2985 0.2983
Echinococcus granulosus Tubulin alpha 1 chain 0.0847 0.2985 0.2983
Trichomonas vaginalis tubulin alpha chain, putative 0.0342 0.1175 0.2934
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0059 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0203 0.0481
Leishmania major gamma-tubulin 0.0691 0.2425 0.6086
Brugia malayi Dopamine receptor protein 1 0.0042 0.0098 0.0247
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0296 0.0745
Loa Loa (eye worm) solute carrier family 6 member 4 0.0182 0.0602 0.1514
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Brugia malayi RNA, U transporter 1 0.0081 0.0237 0.0595
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Onchocerca volvulus 0.0018 0.0012 0.0086
Brugia malayi G-protein coupled receptor 0.0042 0.0098 0.0247
Echinococcus multilocularis lamin dm0 0.0027 0.0045 0.0043
Loa Loa (eye worm) fibroinase 0.0018 0.0012 0.003
Loa Loa (eye worm) tubulin beta chain 0.1124 0.3977 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0051 0.0132 0.0301
Echinococcus granulosus hypothetical protein 0.0042 0.0098 0.0096
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0098 0.0096
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0057
Schistosoma mansoni amine GPCR 0.0042 0.0098 0.0096
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0051 0.0132 0.0301
Echinococcus granulosus tubulin delta chain 0.029 0.0987 0.0986
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0098 0.0247
Entamoeba histolytica acyl-coA synthetase, putative 0.0174 0.0573 0.1415
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0012 0.001
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0018 0.0013 0.0002
Echinococcus multilocularis tubulin alpha chain 0.0847 0.2985 0.2983
Trypanosoma cruzi epsilon tubulin, putative 0.069 0.2422 0.6078
Schistosoma mansoni sodium-dependent amino acid transporter 0.0031 0.0059 0.0057
Loa Loa (eye worm) tubulin alpha 2 0.0557 0.1946 0.4892
Echinococcus granulosus tubulin subunit beta 0.1124 0.3977 0.3976
Loa Loa (eye worm) hypothetical protein 0.0557 0.1946 0.4892
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0098 0.0096
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0059 0.0057
Plasmodium falciparum acyl-CoA synthetase 0.013 0.0415 0.1017
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Onchocerca volvulus 0.0042 0.0098 0.0822
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0012 0.0086
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0098 0.0096
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0132 0.0331
Onchocerca volvulus 0.0042 0.0098 0.0819
Brugia malayi beta-lactamase family protein 0.0042 0.0098 0.0248
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0002 0.0005
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0098 0.0096
Schistosoma mansoni tubulin subunit beta 0.1124 0.3977 0.3976
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0098 0.0096
Echinococcus granulosus tar DNA binding protein 0.0074 0.0213 0.0211
Leishmania major beta tubulin 0.1124 0.3977 1
Loa Loa (eye worm) norepinephrine transporter 0.0182 0.0602 0.1514
Trypanosoma brucei epsilon tubulin 0.0632 0.2215 0.5554
Schistosoma mansoni tubulin subunit alpha 0.0847 0.2985 0.2983
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.003 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0174 0.0573 0.1415
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.029 0.0987 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.0063 0.0126
Schistosoma mansoni hypothetical protein 0.0302 0.1031 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0203 0.0481
Brugia malayi AKH receptor 0.0042 0.0098 0.0247
Leishmania major beta tubulin 0.1124 0.3977 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.003
Echinococcus multilocularis tubulin alpha 1C chain 0.0847 0.2985 0.2983
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0032 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0049 0.0092
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0096 0.0291 0.0289
Onchocerca volvulus 0.0018 0.0012 0.0086
Entamoeba histolytica hypothetical protein 0.0018 0.0013 0.0002
Brugia malayi beta-lactamase 0.0042 0.0098 0.0248
Plasmodium vivax tubulin gamma chain, putative 0.0691 0.2425 0.6086
Trichomonas vaginalis tubulin epsilon chain, putative 0.0847 0.2985 0.7498
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0223 0.0221
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0098 0.0096
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0096 0.0291 0.0703
Loa Loa (eye worm) glutaminase 0.0273 0.0926 0.2327
Echinococcus granulosus tubulin alpha 3 chain 0.0847 0.2985 0.2983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.017 0.04
Trypanosoma cruzi tubulin gamma chain 0.0691 0.2425 0.6086
Leishmania major hypothetical protein, conserved 0.0042 0.0098 0.0218
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0013 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0096 0.0291 0.0731
Brugia malayi larval opioid receptor 0.0042 0.0098 0.0247
Brugia malayi beta-lactamase family protein 0.0042 0.0098 0.0248
Trypanosoma cruzi epsilon tubulin, putative 0.069 0.2422 0.6078
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0067 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0132 0.1057
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0096 0.0291 0.0289
Mycobacterium tuberculosis Probable dehydrogenase 0.0219 0.0733 0.7346
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.017 0.0168
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0132 0.1057
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0015 0.0002 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0098 0.0711
Brugia malayi Cation transporter family protein 0.0015 0.0002 0.0005
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0348 0.1195 0.2983
Loa Loa (eye worm) MH2 domain-containing protein 0.026 0.0882 0.2217
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Schistosoma mansoni opsin-like receptor 0.0042 0.0098 0.0096
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0192 0.0454
Leishmania major acetyl-CoA synthetase, putative 0.0051 0.0132 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Schistosoma mansoni tubulin subunit beta 0.1124 0.3977 0.3976
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0048 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0098 0.0218
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0268 0.0267
Echinococcus multilocularis tubulin delta chain 0.029 0.0987 0.0986
Brugia malayi Tubulin beta-1 chain 0.1124 0.3977 1
Echinococcus multilocularis serotonin transporter 0.0182 0.0602 0.06
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0652 0.2287 0.5738
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0015 0.0002 0.0005
Onchocerca volvulus 0.0031 0.0059 0.0487
Trichomonas vaginalis tubulin beta chain, putative 0.0847 0.2985 0.7498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0296 0.0294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trichomonas vaginalis tubulin alpha chain, putative 0.1124 0.3977 1
Echinococcus granulosus serotonin transporter 0.0182 0.0602 0.06
Loa Loa (eye worm) hypothetical protein 0.0077 0.0223 0.0561
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0012 0.003
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0076 0.0221 0.0525
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.1031 0.2594
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0192 0.0454
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0031 0.0059 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0174 0.0572 0.1439
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0048 0.009
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0086 0.0578
Brugia malayi AMP-binding enzyme family protein 0.0174 0.0573 0.1441
Onchocerca volvulus 0.0042 0.0098 0.0819
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0171 0.0401
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0248
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0098 0.0711
Loa Loa (eye worm) tubulin beta-2A chain 0.1124 0.3977 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0067 0.0065
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0098 0.0711
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0051 0.0132 0.0331
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0043 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0048 0.009
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0098 0.0096
Echinococcus granulosus tubulin alpha chain 0.0847 0.2985 0.2983
Echinococcus granulosus tubulin alpha 1C chain 0.0847 0.2985 0.2983
Loa Loa (eye worm) hypothetical protein 0.0051 0.0132 0.0331
Schistosoma mansoni intermediate filament proteins 0.0027 0.0045 0.0043
Brugia malayi Cation transporter family protein 0.0015 0.0002 0.0005
Onchocerca volvulus 0.0042 0.0098 0.0819
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0038 0.0066
Leishmania major trypanothione reductase 0.0096 0.0292 0.0707
Onchocerca volvulus 0.0018 0.0012 0.0086
Brugia malayi Importin beta-1 subunit 0.0028 0.0049 0.0124
Brugia malayi neuropeptide F receptor 0.0042 0.0098 0.0247
Onchocerca volvulus 0.0031 0.0059 0.0487
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.003
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0632 0.2215 0.5555
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0223 0.0533
Echinococcus multilocularis microtubule associated protein 2 0.2804 1 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.029 0.0987 0.246
Onchocerca volvulus 0.0089 0.0268 0.2271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0098 0.0096
Loa Loa (eye worm) glutaminase 2 0.0273 0.0926 0.2327
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0045 0.0113
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0015 0.0002 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0098 0.0218
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0043 0.0078
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0132 0.0331
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0557 0.1946 0.4876
Echinococcus granulosus allatostatin A receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0149
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0031 0.0059 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0002 0.0005
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Echinococcus granulosus cpg binding protein 0.0031 0.0059 0.0057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0483 0.1214
Onchocerca volvulus 0.0018 0.0012 0.0086
Loa Loa (eye worm) hypothetical protein 0.013 0.0415 0.1044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0221 0.0526
Trichomonas vaginalis importin beta-1, putative 0.0023 0.003 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0153 0.0355
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0063 0.0061
Onchocerca volvulus 0.0031 0.0059 0.0487
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0067 0.0139
Trichomonas vaginalis tubulin, putative 0.0342 0.1175 0.2934
Brugia malayi Tubulin alpha chain 0.0847 0.2985 0.7505
Brugia malayi putative neuropeptide receptor 0.0042 0.0098 0.0247
Plasmodium falciparum tubulin delta chain, putative 0.029 0.0987 0.246
Echinococcus multilocularis Tubulin alpha 1 chain 0.0847 0.2985 0.2983
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0098 0.0096
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.009 0.0196
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0051 0.0132 0.1057
Leishmania major beta tubulin 0.1124 0.3977 1
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Toxoplasma gondii propionate-CoA ligase 0.0051 0.0132 0.0301
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0098 0.0247
Schistosoma mansoni hypothetical protein 0.0047 0.0117 0.0115
Echinococcus granulosus serotonin receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0031 0.0059 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0048 0.009
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0098 0.0096
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0067 0.0137
Brugia malayi G-protein coupled receptor 0.0042 0.0098 0.0247
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Echinococcus multilocularis somatostatin receptor 0.0042 0.0098 0.0096
Echinococcus granulosus tubulin alpha chain 0.0847 0.2985 0.2983
Toxoplasma gondii beta-1 tubulin, putative 0.1124 0.3977 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0133 0.0305
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0292 0.029
Leishmania major beta tubulin 0.1124 0.3977 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0098 0.0096
Schistosoma mansoni Smad4 0.0018 0.0012 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Echinococcus multilocularis geminin 0.0175 0.0576 0.0574
Toxoplasma gondii tubulin, putative 0.0058 0.0155 0.0361
Loa Loa (eye worm) BEN-1 protein 0.1124 0.3977 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0098 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0117 0.0115
Brugia malayi CXXC zinc finger family protein 0.0029 0.0053 0.0133
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0002 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0063 0.0128
Plasmodium falciparum importin beta, putative 0.0028 0.0049 0.0094
Loa Loa (eye worm) hypothetical protein 0.0182 0.0602 0.1514
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0067 0.0139
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0098 0.0218
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0098 0.0096
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0023 0.0027
Echinococcus multilocularis snurportin 1 0.0302 0.1031 0.103
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0051 0.0132 0.1057
Schistosoma mansoni tubulin subunit delta 0.029 0.0987 0.0986
Leishmania major zeta tubulin, putative 0.0896 0.316 0.794
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0051 0.0132 0.1057
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0059 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Leishmania major beta tubulin 0.1124 0.3977 1
Loa Loa (eye worm) tubulin alpha 2 0.0215 0.0718 0.1806
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0219 0.0733 0.7346
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Onchocerca volvulus 0.0042 0.0098 0.0819
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0098 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0133 0.0305
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0013 0.0002
Schistosoma mansoni cellular tumor antigen P53 0.0157 0.0511 0.0509
Loa Loa (eye worm) transcription factor SMAD2 0.026 0.0882 0.2217
Brugia malayi ORL1-like opioid receptor 0.0042 0.0098 0.0247
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0174 0.0573 0.5638
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0098 0.0096
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0067 0.0169
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0098 0.0096
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0098 0.0096
Plasmodium falciparum glutathione reductase 0.0033 0.0067 0.0139
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0098 0.0247
Onchocerca volvulus 0.0042 0.0098 0.0822
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0098 0.0247
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0098 0.0247
Echinococcus multilocularis musashi 0.0027 0.0045 0.0043
Onchocerca volvulus 0.0042 0.0098 0.0819
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0098 0.0096
Mycobacterium tuberculosis Conserved protein 0.0042 0.0098 0.0711
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0098 0.0711
Trichomonas vaginalis tubulin beta chain, putative 0.0847 0.2985 0.7498
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0049 0.0092
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0069 0.0067
Trypanosoma brucei alpha tubulin, putative 0.0342 0.1175 0.2933
Onchocerca volvulus 0.0042 0.0098 0.0819
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0069 0.0144
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0098 0.0711
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0132 0.1057
Leishmania major beta tubulin 0.1124 0.3977 1
Trypanosoma brucei epsilon tubulin 0.069 0.2422 0.6077
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0505 0.1757 0.4419
Echinococcus granulosus beta tubulin 0.1124 0.3977 0.3976
Schistosoma mansoni acetyl-CoA synthetase 0.0051 0.0132 0.013
Schistosoma mansoni hypothetical protein 0.0175 0.0576 0.0574
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0149
Brugia malayi Dopamine receptor 0.0042 0.0098 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Brugia malayi hypothetical protein 0.0028 0.0048 0.012
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0182 0.0602 0.1514
Entamoeba histolytica hypothetical protein 0.0077 0.0224 0.0534
Echinococcus granulosus snurportin 1 0.0302 0.1031 0.103
Onchocerca volvulus 0.0051 0.0132 0.1105
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0051 0.0132 0.1057
Onchocerca volvulus 0.0018 0.0012 0.0086
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0002 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0051 0.0132 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0133 0.0305
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0098 0.0096
Brugia malayi RNA binding protein 0.0074 0.0213 0.0535
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0063 0.0061
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0023 0.0021
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0076 0.0221 0.0527
Echinococcus granulosus tubulin epsilon chain 0.069 0.2422 0.2421
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0059 0.0149
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0067 0.0139
Echinococcus granulosus importin subunit beta 1 0.0028 0.0049 0.0048
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0067 0.0065
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Plasmodium falciparum glutathione reductase 0.0096 0.0292 0.0707
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0151 0.035
Onchocerca volvulus 0.0042 0.0098 0.0819
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Schistosoma mansoni cpg binding protein 0.0031 0.0059 0.0057
Echinococcus multilocularis tubulin subunit beta 0.1124 0.3977 0.3976
Trichomonas vaginalis antibiotic synthetase, putative 0.0051 0.0132 0.0301
Mycobacterium tuberculosis Cell division protein FtsZ 0.029 0.0987 1
Echinococcus granulosus smad 0.0018 0.0012 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0098 0.0248
Entamoeba histolytica protein kinase rad3, putative 0.0018 0.0013 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Loa Loa (eye worm) tubulin beta-4 chain 0.1124 0.3977 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0059 0.0057
Mycobacterium leprae cell division protein FtsZ 0.029 0.0987 1
Brugia malayi TAR-binding protein 0.0074 0.0213 0.0535
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0296 0.0294
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0132 0.1057
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0223 0.2015
Plasmodium falciparum tubulin gamma chain 0.0691 0.2425 0.6086
Echinococcus multilocularis Smad4 0.0018 0.0012 0.001
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0012 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0213 0.0211
Trichomonas vaginalis tubulin epsilon chain, putative 0.1124 0.3977 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Echinococcus multilocularis serotonin receptor 0.0042 0.0098 0.0096
Onchocerca volvulus 0.0042 0.0098 0.0819
Onchocerca volvulus 0.0042 0.0098 0.0822
Leishmania major beta tubulin 0.1124 0.3977 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0051 0.0132 0.013
Toxoplasma gondii alpha-tubulin I, putative 0.0847 0.2985 0.7498
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0098 0.0218
Leishmania major 4-coumarate:coa ligase-like protein 0.0174 0.0573 0.1415
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0098 0.0218
Schistosoma mansoni biogenic amine receptor 0.0042 0.0098 0.0096
Echinococcus granulosus Tubulin alpha 1 chain 0.0847 0.2985 0.2983
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0098 0.0247
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0098 0.0096
Trypanosoma brucei trypanothione reductase 0.0096 0.0292 0.0705
Echinococcus granulosus g protein coupled receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0098 0.0096
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0223 0.195
Schistosoma mansoni hypothetical protein 0.0047 0.0117 0.0115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0149
Brugia malayi Tubulin alpha-2 chain 0.0847 0.2985 0.7505
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Leishmania major beta tubulin 0.1124 0.3977 1
Leishmania major acetyl-CoA synthetase, putative 0.0051 0.0132 0.0301
Schistosoma mansoni tubulin subunit beta 0.1124 0.3977 0.3976
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0132 0.1057
Plasmodium falciparum thioredoxin reductase 0.0096 0.0292 0.0707
Brugia malayi alpha-tubulin 0.0847 0.2985 0.7505
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0051 0.0132 0.0985
Giardia lamblia Delta tubulin 0.029 0.0987 0.2439
Echinococcus multilocularis tubulin gamma 1 chain 0.0691 0.2425 0.2424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0292 0.0735
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0248
Entamoeba histolytica hypothetical protein 0.0077 0.0224 0.0534
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0098 0.0096
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0098 0.0247
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0098 0.0096
Loa Loa (eye worm) oxidoreductase 0.0051 0.0132 0.0331
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0134 0.0132
Loa Loa (eye worm) hypothetical protein 0.013 0.0415 0.1044
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0031 0.0059 0.0149
Treponema pallidum sodium- and chloride- dependent transporter 0.0182 0.0602 0.5976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0133 0.0305
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.011 0.0245
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0059 0.0119
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Trichomonas vaginalis tubulin beta chain, putative 0.0847 0.2985 0.7498
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0096 0.0291 0.0703
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0224 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0153 0.0355
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0483 0.1214
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0224 0.0222
Brugia malayi hypoxia-induced factor 1 0.0161 0.0524 0.1317
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0015 0.0002 0.0005
Giardia lamblia Beta tubulin 0.1124 0.3977 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0069 0.0067
Schistosoma mansoni smad 0.0018 0.0012 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0049 0.0094
Loa Loa (eye worm) tubulin alpha 2 0.0557 0.1946 0.4892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0291 0.0703
Loa Loa (eye worm) tubulin alpha chain 0.0847 0.2985 0.7505
Brugia malayi intermediate filament protein 0.0027 0.0045 0.0113
Echinococcus granulosus Smad4 0.0018 0.0012 0.001
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0069 0.0144
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0051 0.0132 0.0301
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0098 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0153 0.0355
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0038 0.0066
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0248
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0012 0.001
Plasmodium falciparum transporter, putative 0.0031 0.0059 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0221 0.0526
Echinococcus granulosus Tubulin beta 2C chain 0.1124 0.3977 0.3976
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0098 0.0096
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0098 0.0096
Schistosoma mansoni hypothetical protein 0.0175 0.0576 0.0574
Schistosoma mansoni alpha tubulin 0.0847 0.2985 0.2983
Brugia malayi Dopamine receptor protein 2 0.0042 0.0098 0.0247
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0224 0.0222
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0213 0.0535
Loa Loa (eye worm) hypothetical protein 0.0445 0.1542 0.3878
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0174 0.0573 0.5673
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0117 0.0115
Echinococcus granulosus tubulin alpha chain 0.0847 0.2985 0.2983
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1124 0.3977 0.3976
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.0789
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0059 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0059 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0098 0.0096
Trypanosoma cruzi tubulin delta chain 0.0652 0.2287 0.5738
Loa Loa (eye worm) hypothetical protein 0.0847 0.2985 0.7505
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0192 0.0454
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0213 0.0535
Trypanosoma brucei alpha tubulin 0.0847 0.2985 0.7497
Loa Loa (eye worm) hypothetical protein 0.013 0.0415 0.1044
Onchocerca volvulus 0.0042 0.0098 0.0819
Trichomonas vaginalis tubulin beta chain, putative 0.0847 0.2985 0.7498
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0174 0.0573 0.5673
Toxoplasma gondii hypothetical protein 0.0026 0.0043 0.0078
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0043 0.005
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.0025
Echinococcus granulosus intermediate filament protein 0.0027 0.0045 0.0043
Plasmodium vivax amine transporter, putative 0.0031 0.0059 0.0119
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0098 0.0216
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0098 0.0096
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0098 0.0096
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0069 0.0144
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0342 0.1175 0.2934
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0098 0.0097
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0067 0.0385
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0069 0.0144
Echinococcus granulosus Tubulin beta 2C chain 0.1124 0.3977 0.3976
Mycobacterium ulcerans hypothetical protein 0.0042 0.0098 0.0711
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0051 0.0132 0.03
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0098 0.0096
Echinococcus granulosus tubulin beta 4A class IVa 0.1124 0.3977 0.3976
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0031 0.0059 0.0057
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0505 0.1757 0.4402
Loa Loa (eye worm) beta-lactamase 0.0042 0.0098 0.0248
Onchocerca volvulus 0.0042 0.0098 0.0819
Mycobacterium ulcerans beta-lactamase 0.0042 0.0098 0.0711
Mycobacterium ulcerans hypothetical protein 0.0174 0.0573 0.5673
Echinococcus granulosus GPCR family 2 0.0047 0.0117 0.0115
Leishmania major cathepsin L-like protease 0.0068 0.0192 0.0454
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0287 0.0978 0.2459
Echinococcus granulosus alpha tubulin 0.0847 0.2985 0.2983
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0268 0.0267
Mycobacterium ulcerans glutaminase 0.0273 0.0926 0.9356
Loa Loa (eye worm) beta-tubulin 0.1124 0.3977 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0012 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0067 0.0139
Brugia malayi Tubulin beta chain 0.0342 0.1175 0.2955
Trichomonas vaginalis tubulin alpha chain, putative 0.0342 0.1175 0.2934
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0098 0.0096
Entamoeba histolytica hypothetical protein 0.0077 0.0224 0.0534
Onchocerca volvulus 0.0038 0.0086 0.0714
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0069 0.0144
Brugia malayi GnHR receptor homolog 0.0042 0.0098 0.0247
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0132 0.1057
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis nmda type glutamate receptor 0.0032 0.0063 0.0061
Echinococcus granulosus tubulin beta 1 chain 0.1124 0.3977 0.3976
Echinococcus granulosus single minded 2 0.0038 0.0086 0.0084
Schistosoma mansoni amine GPCR 0.0042 0.0098 0.0096
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0069 0.0144
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.1439 0.1437
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0096 0.0291 0.0701
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0023 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0117 0.0115
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.1542 0.3878
Entamoeba histolytica tubulin gamma chain 0.0691 0.2425 0.6086
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0063 0.0126
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0098 0.0097
Brugia malayi Cytochrome P450 family protein 0.0028 0.0048 0.0121
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0059 0.0057
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0012 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0002 0.0005
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0067 0.0139
Brugia malayi hypothetical protein 0.0018 0.0013 0.0031
Schistosoma mansoni tubulin subunit beta 0.1124 0.3977 0.3976
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0051
Schistosoma mansoni neuropeptide receptor 0.0042 0.0098 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0213 0.0211
Onchocerca volvulus 0.0051 0.0132 0.1105
Onchocerca volvulus 0.0027 0.0045 0.0367
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0098 0.0247
Echinococcus granulosus g protein coupled receptor 0.0042 0.0098 0.0096
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0132 0.1057
Trypanosoma cruzi alpha tubulin, putative 0.0847 0.2985 0.7498
Trypanosoma cruzi zeta tubulin, putative 0.0896 0.316 0.794
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0096 0.0291 0.0703
Loa Loa (eye worm) RNA binding protein 0.0074 0.0213 0.0535
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0069 0.0144
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0051 0.0132 0.0301
Loa Loa (eye worm) tubulin alpha-2 chain 0.0847 0.2985 0.7505
Trichomonas vaginalis tubulin gamma chain, putative 0.0691 0.2425 0.6086
Entamoeba histolytica hypothetical protein 0.0025 0.0038 0.0066
Onchocerca volvulus 0.0042 0.0098 0.0819
Onchocerca volvulus 0.0051 0.0132 0.1105
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.1542 0.3858
Brugia malayi MH2 domain containing protein 0.026 0.0882 0.2217
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0098 0.0096
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0117 0.0295
Brugia malayi Cation transporter family protein 0.0015 0.0002 0.0005
Onchocerca volvulus 0.0042 0.0098 0.0819
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0051 0.0132 0.0331
Echinococcus multilocularis hypothetical protein 0.0847 0.2985 0.2983
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0069 0.0174
Echinococcus granulosus peroxisome assembly protein 26 0.0847 0.2985 0.2983
Plasmodium falciparum alpha tubulin 1 0.0847 0.2985 0.7498
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0223 0.0221
Echinococcus granulosus neuropeptide receptor 0.0042 0.0098 0.0096
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0132 0.0331
Echinococcus multilocularis beta tubulin 0.1124 0.3977 0.3976
Onchocerca volvulus 0.0029 0.0053 0.0432
Trypanosoma brucei alpha tubulin 0.0847 0.2985 0.7497
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0012 0.001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0827 0.2912 0.2911
Schistosoma mansoni tubulin subunit alpha 0.0847 0.2985 0.2983
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0314 0.0789
Brugia malayi MH2 domain containing protein 0.0018 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Onchocerca volvulus 0.0042 0.0098 0.0819
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Echinococcus granulosus Tubulin beta 2C chain 0.1124 0.3977 0.3976
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0098 0.0097
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0132 0.1057
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0059 0.0057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0098 0.0711
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0046
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0098 0.0247
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0051 0.0132 0.0331
Plasmodium falciparum tubulin epsilon chain, putative 0.069 0.2422 0.6078
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0174 0.0573 0.5638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Giardia lamblia Alpha-tubulin 0.0847 0.2985 0.7491
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0049 0.0048
Brugia malayi glutathione reductase 0.0096 0.0292 0.0735
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.014 0.0322
Onchocerca volvulus 0.0018 0.0012 0.0086
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0067 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0098 0.0096
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0098 0.0711
Schistosoma mansoni ran 0.0021 0.0023 0.0021
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0098 0.0096
Mycobacterium ulcerans cell division protein FtsZ 0.029 0.0987 1
Loa Loa (eye worm) tubulin beta-1 chain 0.1124 0.3977 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0098 0.0248
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.0027
Echinococcus granulosus orexin receptor type 2 0.0042 0.0098 0.0096
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0098 0.0247
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0015 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0203 0.0481
Echinococcus multilocularis tubulin alpha 0.0632 0.2215 0.2213
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0146 0.0339
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0012 0.0029
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) BEN-1 protein 0.1124 0.3977 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0067 0.0139
Schistosoma mansoni neuropeptide receptor 0.0042 0.0098 0.0096
Trypanosoma brucei tubulin delta chain 0.0652 0.2287 0.5737
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0015 0.0002 0.0005
Brugia malayi Serotonin receptor 0.0597 0.209 0.5255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0133 0.0305
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0098 0.0819
Brugia malayi MH2 domain containing protein 0.0018 0.0012 0.0029
Trypanosoma brucei epsilon tubulin 0.069 0.2422 0.6077
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0012 0.0086
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0067 0.0307
Plasmodium falciparum tubulin beta chain 0.1124 0.3977 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0012 0.001
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0027
Leishmania major hypothetical protein, conserved 0.0028 0.0048 0.009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0067 0.0385
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0012 0.001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0098 0.0247
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0038 0.0066
Leishmania major cathepsin L-like protease 0.0068 0.0192 0.0454
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0012 0.003
Leishmania major cathepsin L-like protease 0.0068 0.0192 0.0454
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1042 0.3683 0.3682
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0296 0.0294
Brugia malayi glutaminase DH11.1 0.0273 0.0926 0.2327
Giardia lamblia Gamma tubulin 0.0691 0.2425 0.6076
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0038 0.0066
Echinococcus multilocularis peroxisome assembly protein 26 0.0847 0.2985 0.2983
Toxoplasma gondii beta-tubulin, putative 0.1124 0.3977 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0221 0.0526
Trichomonas vaginalis tubulin gamma chain, putative 0.069 0.2422 0.6078
Echinococcus multilocularis tubulin beta 1 chain 0.1124 0.3977 0.3976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0221 0.0526
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0098 0.0218
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0059 0.0149
Trichomonas vaginalis glutaminase, putative 0.0273 0.0926 0.2304
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0109
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0002
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Schistosoma mansoni myosin xvIII 0.0042 0.0098 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0038 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0132 0.1057
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0059 0.0149
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0098 0.0096
Brugia malayi neuropeptide F receptor 0.0042 0.0098 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0063 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0063 0.0128
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0241 0.0576
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0213 0.0535
Giardia lamblia Epsilon tubulin 0.0348 0.1195 0.2964
Echinococcus multilocularis tubulin alpha 1C chain 0.0847 0.2985 0.2983
Schistosoma mansoni tubulin subunit beta 0.029 0.0987 0.0986
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.0063 0.0128
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0219 0.0733 0.7324
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0219 0.0733 0.7346
Trypanosoma cruzi zeta tubulin, putative 0.0896 0.316 0.794
Schistosoma mansoni biogenic amine receptor 0.0042 0.0098 0.0096
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0067 0.0385
Schistosoma mansoni hypothetical protein 0.0047 0.0117 0.0115
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0067 0.0137
Loa Loa (eye worm) hypothetical protein 0.0028 0.0049 0.0124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0123 0.039 0.3755
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0098 0.0247
Brugia malayi follicle stimulating hormone receptor 0.0287 0.0978 0.2459
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0268 0.0267
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0069 0.0067
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.013 0.0415 0.1044
Echinococcus multilocularis tubulin alpha 3 chain 0.0847 0.2985 0.2983
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trypanosoma brucei beta tubulin 0.0632 0.2215 0.5554
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0067 0.0139
Echinococcus multilocularis sex peptide receptor 0.0042 0.0098 0.0096
Brugia malayi Tubulin beta chain 0.029 0.0987 0.2483
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0051 0.0132 0.013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0123 0.039 0.3755
Brugia malayi isocitrate dehydrogenase 0.0034 0.0069 0.0174
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0243 0.0821 0.8262
Trichomonas vaginalis conserved hypothetical protein 0.029 0.0987 0.246
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0051 0.0132 0.0301
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0098 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Brugia malayi tubulin alpha chain - mouse 0.0847 0.2985 0.7505
Brugia malayi hypothetical protein 0.0031 0.0059 0.0149
Onchocerca volvulus Huntingtin homolog 0.0125 0.0395 0.3346
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0063 0.0158
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0051 0.0132 0.1057
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0038 0.0081
Trypanosoma brucei zeta tubulin, putative 0.0896 0.316 0.794
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.1542 0.3859
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Leishmania major beta tubulin 0.1124 0.3977 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Brugia malayi PAS domain containing protein 0.0052 0.0134 0.0337
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0067 0.0137
Echinococcus granulosus Tubulin alpha 1 chain 0.0847 0.2985 0.2983
Echinococcus multilocularis tubulin epsilon chain 0.069 0.2422 0.2421
Onchocerca volvulus 0.0182 0.0602 0.5116
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0012 0.001
Mycobacterium leprae Probable lipase LipE 0.0042 0.0098 0.0636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0203 0.0481
Echinococcus granulosus tubulin alpha chain 0.0847 0.2985 0.2983
Mycobacterium ulcerans acyl-CoA synthetase 0.0174 0.0573 0.5673
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.002 0.0021
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0219 0.0733 0.7346
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0038 0.0081
Trichomonas vaginalis tubulin, putative 0.1124 0.3977 1
Schistosoma mansoni lamin 0.0027 0.0045 0.0043
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0128 0.0126
Echinococcus granulosus geminin 0.0175 0.0576 0.0574
Trypanosoma brucei beta tubulin 0.1124 0.3977 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0059 0.0057
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0063 0.0128
Loa Loa (eye worm) hypoxia-induced factor 1 0.0161 0.0524 0.1317
Mycobacterium ulcerans fatty-acid-CoA ligase 0.013 0.0415 0.4021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0174 0.0573 0.1415
Echinococcus granulosus somatostatin receptor 0.0042 0.0098 0.0096
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0174 0.0573 0.1441
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0067 0.0139
Leishmania major beta tubulin 0.1124 0.3977 1
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0098 0.0096
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0086 0.0084
Brugia malayi hypothetical protein 0.0174 0.0572 0.1439
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0174 0.0573 0.5673
Brugia malayi Thioredoxin reductase 0.0096 0.0292 0.0735
Giardia lamblia GTOR 0.0096 0.0291 0.0678
Echinococcus multilocularis cysteine protease 0.0018 0.0012 0.001
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0098 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0133 0.0305
Loa Loa (eye worm) LGC-31 protein 0.0015 0.0002 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0067 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0174 0.0573 0.1441
Echinococcus multilocularis tumor protein p63 0.1073 0.3793 0.3792
Echinococcus granulosus tubulin alpha chain 0.0847 0.2985 0.2983
Echinococcus granulosus Tubulin beta 2C chain 0.1124 0.3977 0.3976
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0067 0.0113
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0067 0.0139
Trichomonas vaginalis tubulin gamma chain, putative 0.029 0.0987 0.246
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Plasmodium vivax glutathione reductase, putative 0.0096 0.0292 0.0707
Loa Loa (eye worm) alpha-tubulin 0.0847 0.2985 0.7505
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0069 0.0067
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0098 0.0096
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0036 0.009
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0069 0.0174
Entamoeba histolytica tubulin family protein 0.1124 0.3977 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0128 0.0951
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Trypanosoma cruzi target of rapamycin kinase 3 0.0076 0.0221 0.0527
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0268 0.0675
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0067 0.0139
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0044 0.0106 0.0791
Echinococcus granulosus sex peptide receptor 0.0042 0.0098 0.0096
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Schistosoma mansoni biogenic amine receptor 0.0042 0.0098 0.0096
Entamoeba histolytica tubulin alpha chain, putative 0.0847 0.2985 0.7498
Echinococcus granulosus fmrfamide receptor 0.0042 0.0098 0.0096
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0051 0.0132 0.0301
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0051 0.0132 0.0301
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0213 0.0211
Loa Loa (eye worm) cysteine protease 0.0018 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0048 0.012
Loa Loa (eye worm) tubulin gamma chain 0.0691 0.2425 0.6098
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0067 0.0139
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0096 0.0291 0.0703
Leishmania major beta tubulin 0.1124 0.3977 1
Toxoplasma gondii hypothetical protein 0.0031 0.0059 0.0119
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0223 0.195
Toxoplasma gondii alpha tubulin TUBA1 0.0847 0.2985 0.7498
Brugia malayi hypothetical protein 0.0042 0.0098 0.0247
Plasmodium vivax acyl-CoA synthetase, putative 0.013 0.0415 0.1017
Schistosoma mansoni hypothetical protein 0.0416 0.1439 0.1437
Leishmania major beta tubulin 0.1124 0.3977 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Schistosoma mansoni neuropeptide receptor 0.0042 0.0098 0.0096
Treponema pallidum cell division protein FtsZ 0.029 0.0987 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0015 0.0002 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0098 0.0096
Onchocerca volvulus 0.0042 0.0098 0.0819
Onchocerca volvulus 0.0342 0.1175 1
Plasmodium falciparum alpha tubulin 2 0.0847 0.2985 0.7498
Trichomonas vaginalis tubulin epsilon chain, putative 0.1124 0.3977 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0174 0.0573 0.1415
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0098 0.0096
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0059 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.0132 0.1057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0123 0.039 0.3755
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0128 0.1024
Echinococcus granulosus lamin 0.0027 0.0045 0.0043
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0098 0.0097
Loa Loa (eye worm) hypothetical protein 0.0125 0.0395 0.0992
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0219 0.0733 0.7346
Trichomonas vaginalis tubulin beta chain, putative 0.0847 0.2985 0.7498
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0174 0.0573 0.5673
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0018 0.0013 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0096 0.0291 0.0703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0203 0.0481
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.003
Schistosoma mansoni amine GPCR 0.0042 0.0098 0.0096
Echinococcus multilocularis tubulin alpha chain 0.0847 0.2985 0.2983
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0013 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0098 0.0096
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0013 0.0011
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0128 0.0126
Schistosoma mansoni importin beta-1 0.0028 0.0049 0.0048
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0015 0.0002 0.0005
Trichomonas vaginalis ran, putative 0.0021 0.0023 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0192 0.0454
Echinococcus granulosus cathepsin l1 0.0018 0.0012 0.001
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0086 0.0216
Plasmodium falciparum amino acid transporter, putative 0.0031 0.0059 0.0119
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0098 0.0096
Entamoeba histolytica tubulin alpha-1 chain 0.0847 0.2985 0.7498
Brugia malayi Serotonin receptor 0.0042 0.0098 0.0247
Schistosoma mansoni tubulin subunit alpha 0.029 0.0987 0.0986
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0067 0.0959
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0038 0.02
Giardia lamblia Beta tubulin 0.1124 0.3977 1
Loa Loa (eye worm) glutathione reductase 0.0096 0.0292 0.0735
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Echinococcus granulosus tubulin alpha 3 chain 0.0847 0.2985 0.2983
Entamoeba histolytica tubulin family protein 0.1124 0.3977 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0174 0.0573 0.5673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0192 0.0452
Giardia lamblia Alpha-tubulin 0.0847 0.2985 0.7491
Echinococcus multilocularis Tubulin alpha 1 chain 0.0847 0.2985 0.2983
Mycobacterium ulcerans acetyl-CoA synthetase 0.0051 0.0132 0.1057
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0048 0.009
Schistosoma mansoni cpg binding protein 0.0029 0.0053 0.0051
Schistosoma mansoni hypothetical protein 0.0077 0.0224 0.0222
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0098 0.0247
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0098 0.0096
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Leishmania major importin beta-1 subunit, putative 0.0023 0.003 0.0046
Plasmodium vivax acetyl-CoA synthetase, putative 0.0051 0.0132 0.0301
Brugia malayi Cell division protein ftsZ 0.029 0.0987 0.2483
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0031 0.0059 0.0744
Mycobacterium tuberculosis Conserved protein 0.0042 0.0098 0.0711
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0059 0.0149
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0051 0.0132 0.1057
Onchocerca volvulus 0.0018 0.0012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Leishmania major alpha tubulin 0.0847 0.2985 0.7498
Echinococcus multilocularis Tubulin beta 2C chain 0.1124 0.3977 0.3976
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0128 0.1024
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0132 0.1057
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0051 0.0132 0.1057
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0067 0.0139
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0149
Echinococcus granulosus neuropeptide receptor 0.0042 0.0098 0.0096
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0098 0.0096
Entamoeba histolytica acyl-CoA synthetase, putative 0.0174 0.0573 0.1415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0203 0.0481
Brugia malayi beta-tubulin, identical 0.1124 0.3977 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0045 0.0113
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0012 0.001
Entamoeba histolytica Ran family GTPase 0.0021 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0247
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0013 0.0011

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.9 nM Displacement of [3H](+)-pentazocine from guinea pig sigma1 opioid receptor by liquid scintillation counting ChEMBL. 20684615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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