Detailed information for compound 1176496

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1507.85 | Formula: C75H122N14O18
  • H donors: 15 H acceptors: 17 LogP: 3.68 Rotable bonds: 43
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCC[C@@H](C(=O)N[C@@H](C(=O)N[C@@H]1[C@H](C)OC(=O)[C@@H](NC(=O)/C(=C/C)/NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)[C@@H](CC)C)C(C)C)Cc1ccccc1)C(C)C)[C@@H](CC)C)NC(=O)[C@H]1CCCN1C(=O)[C@@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](C(C)C)NC(=O)CCCC(C)C)CCC(=O)O
  • InChi: 1S/C75H122N14O18/c1-18-43(14)59(71(102)88-62-46(17)107-75(106)58(42(12)13)84-63(94)48(20-3)77-66(97)51(37-47-28-22-21-23-29-47)80-68(99)56(40(8)9)82-70(101)60(44(15)19-2)86-73(62)104)85-64(95)49(30-25-35-76)78-67(98)52-31-26-36-89(52)74(105)57(41(10)11)83-65(96)50(33-34-54(92)93)79-72(103)61(45(16)90)87-69(100)55(39(6)7)81-53(91)32-24-27-38(4)5/h20-23,28-29,38-46,49-52,55-62,90H,18-19,24-27,30-37,76H2,1-17H3,(H,77,97)(H,78,98)(H,79,103)(H,80,99)(H,81,91)(H,82,101)(H,83,96)(H,84,94)(H,85,95)(H,86,104)(H,87,100)(H,88,102)(H,92,93)/b48-20-/t43-,44-,45-,46+,49+,50+,51+,52-,55-,56-,57-,58+,59-,60-,61+,62-/m1/s1
  • InChiKey: YXLHZSWDNMYIJO-MSGJRUJVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Echinococcus multilocularis RUN 0.0019 0.0112 0.0112
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0068 0.0288
Leishmania major cathepsin L-like protease 0.0018 0.0097 0.112
Trypanosoma brucei heat shock protein, putative 0.0037 0.0297 0.4161
Loa Loa (eye worm) hypothetical protein 0.0075 0.0707 0.248
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0006 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0225 0.0327
Onchocerca volvulus 0.0028 0.0203 0.123
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0108 0.0177
Entamoeba histolytica hypothetical protein 0.0077 0.0731 0.6434
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.007 0.0914
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trypanosoma brucei heat shock protein, putative 0.0037 0.0297 0.4161
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0112 0.0112
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0108 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0117 0.0193
Loa Loa (eye worm) heat shock protein 75 0.0015 0.0068 0.0237
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0108 0.1284
Leishmania major cathepsin L-like protease 0.0018 0.0097 0.112
Echinococcus granulosus solute carrier family 22 0.003 0.0225 0.045
Plasmodium falciparum endoplasmin, putative 0.0022 0.0147 0.0149
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0366 0.1673
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0218 0.0987
Giardia lamblia Hexose transporter 0.003 0.0225 0.351
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Schistosoma mansoni sugar transporter 0.003 0.0225 0.045
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0297 0.4161
Loa Loa (eye worm) hypothetical protein 0.0028 0.0203 0.0713
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0598 0.0626
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0598 0.0925
Brugia malayi CXXC zinc finger family protein 0.0034 0.0266 0.0932
Brugia malayi Ets-domain containing protein 0.0074 0.0697 0.2446
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0012 0.0035 0.0217
Schistosoma mansoni hypothetical protein 0.0372 0.3875 0.7752
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0035 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.002 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0097 0.0425
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0143 0.0246
Trypanosoma brucei glucose transporter 2A 0.0066 0.0607 0.8572
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0097 0.0425
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0598 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.5011 1
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0035 0.0258
Mycobacterium ulcerans hypothetical protein 0.0075 0.0707 1
Giardia lamblia DINP protein human, muc B family 0.0022 0.0143 0.2032
Plasmodium falciparum hexose transporter 0.0211 0.2161 0.2278
Brugia malayi latrophilin 2 splice variant baaae 0.0115 0.1136 0.3985
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0108 0.0177
Toxoplasma gondii sugar transporter ST1 0.003 0.0225 0.0327
Onchocerca volvulus 0.003 0.0225 0.1385
Entamoeba histolytica hypothetical protein 0.0011 0.0031 0.0223
Leishmania major hypothetical protein, conserved 0.0075 0.0707 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0434 0.1988
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.2161 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0031 0.0117
Loa Loa (eye worm) cytochrome P450 0.0019 0.0108 0.038
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0297 0.4161
Trypanosoma brucei unspecified product 0.001 0.002 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0203 0.0713
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0607 0.279
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0035 0.0123
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0297 0.4161
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0607 0.279
Onchocerca volvulus 0.003 0.0225 0.1385
Brugia malayi Ets-domain containing protein 0.0011 0.0023 0.008
Plasmodium vivax vivapain-2 0.0018 0.0097 0.0097
Onchocerca volvulus Huntingtin homolog 0.0143 0.1433 1
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0031 0.0153
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0598 0.0626
Mycobacterium ulcerans heat shock protein 90 0.0029 0.0218 0.2883
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0035 0.0419
Toxoplasma gondii protein kinase, putative 0.0597 0.6273 1
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0097 0.0341
Echinococcus multilocularis heat shock protein 0.0037 0.0297 0.0297
Entamoeba histolytica hypothetical protein 0.0077 0.0731 0.6434
Schistosoma mansoni sugar transporter 0.003 0.0225 0.045
Trypanosoma brucei glucose transporter, putative 0.0066 0.0607 0.8572
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0108 0.1284
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0696 0.073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0035 0.0135
Schistosoma mansoni hypothetical protein 0.0053 0.0477 0.0954
Giardia lamblia Grp94/Hsp90 0.0029 0.0218 0.3387
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0108 0.0177
Brugia malayi beta-lactamase family protein 0.0075 0.0707 0.248
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0097 0.0194
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0411 0.5781
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Echinococcus multilocularis solute carrier family 22 0.003 0.0225 0.0225
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0411 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0108 0.1284
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0097 0.1306
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0218 0.3387
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0108 0.1466
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0112 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Loa Loa (eye worm) histone methyltransferase 0.001 0.0019 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0122
Echinococcus multilocularis solute carrier family 22 0.003 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0108 0.0177
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0584 0.1168
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0598 0.0626
Loa Loa (eye worm) endoplasmin 0.0037 0.0297 0.1043
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0031 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Trypanosoma brucei glucose transporter 1E 0.0066 0.0607 0.8572
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0225 0.2981
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0035 0.0419
Trypanosoma cruzi hexose transporter 0.0066 0.0607 0.8572
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0108 0.1284
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.2851 0.2851
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0335 0.4587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Echinococcus granulosus solute carrier family 22 0.003 0.0225 0.045
Onchocerca volvulus 0.0056 0.0508 0.3407
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0225 0.045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0097 0.0341
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0108 0.1284
Toxoplasma gondii cathepsin CPL 0.0018 0.0097 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0707 0.3254
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0023 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0097 0.0812
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0411 0.0822
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0598 0.1196
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0143 0.1791
Brugia malayi Sugar transporter family protein 0.0211 0.2161 0.7579
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0411 0.5691
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0225 0.1018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0566 0.7984
Echinococcus granulosus geminin 0.0372 0.3875 0.7752
Schistosoma mansoni cpg binding protein 0.0034 0.0266 0.0531
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0015 0.0068 0.0068
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0607 0.8572
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0225 0.0225
Plasmodium falciparum protein kinase 6 0.0897 0.9469 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0122
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0129 0.013
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0225 0.0789
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.007 0.0099
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0696 0.9844
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0023 0.0045
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0023 0.0023
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0031 0.0153
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0297 0.0443
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0035 0.0123
Brugia malayi hypothetical protein 0.0019 0.0112 0.0392
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0307 0.4305
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0477 0.0954
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Schistosoma mansoni patched 1 0.0049 0.0434 0.0868
Schistosoma mansoni hypothetical protein 0.0053 0.0477 0.0954
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0297 0.2588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Loa Loa (eye worm) hypothetical protein 0.0063 0.0584 0.2048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0255 0.0894
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0628 0.8874
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Loa Loa (eye worm) fibroinase 0.0018 0.0097 0.0341
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0023 0.0023
Trypanosoma brucei glucose transporter, putative 0.0066 0.0607 0.8572
Echinococcus multilocularis Niemann Pick C1 protein 0.0164 0.1659 0.1659
Brugia malayi hypothetical protein 0.0019 0.0112 0.0392
Echinococcus multilocularis protein C ets 2 0.0011 0.0023 0.0023
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0035 0.0123
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0023 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0117 0.0193
Echinococcus multilocularis heat shock protein 90 0.0037 0.0297 0.0297
Entamoeba histolytica protein kinase, putative 0.0065 0.0598 0.5253
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0035 0.0035
Leishmania major cathepsin L-like protease 0.0068 0.0628 0.885
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0598 0.0925
Trypanosoma brucei unspecified product 0.001 0.002 0.0199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0451
Entamoeba histolytica hypothetical protein 0.0077 0.0731 0.6434
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0584 0.821
Onchocerca volvulus Putative transporter 0.003 0.0225 0.1385
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0023 0.0045
Leishmania major glucose transporter, lmgt2 0.0066 0.0607 0.8542
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0108 0.0177
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0147 0.6199
Loa Loa (eye worm) hypothetical protein 0.0075 0.0707 0.248
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0607 0.8572
Mycobacterium ulcerans hypothetical protein 0.0028 0.0203 0.2666
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0366 0.1673
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.007 0.007
Brugia malayi Cathepsin L-like precursor 0.0018 0.0097 0.0341
Brugia malayi Cathepsin L-like precursor 0.0018 0.0097 0.0341
Schistosoma mansoni protein kinase 0.0065 0.0598 0.1196
Onchocerca volvulus 0.0075 0.0707 0.4823
Brugia malayi Hsp90 protein 0.0015 0.0068 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0108 0.1284
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0035 0.0215
Onchocerca volvulus 0.0012 0.0035 0.0028
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Echinococcus multilocularis solute carrier family 22 0.003 0.0225 0.0225
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0147 0.0656
Echinococcus multilocularis solute carrier family 22 0.003 0.0225 0.0225
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0607 0.8572
Trypanosoma brucei glucose transporter, putative 0.0066 0.0607 0.8572
Brugia malayi Doublecortin family protein 0.0019 0.0112 0.0392
Leishmania major cytochrome p450-like protein 0.0019 0.0108 0.1284
Schistosoma mansoni hypothetical protein 0.0048 0.0415 0.083
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0097 0.0097
Brugia malayi Cam kinase protein 1 0.0065 0.0598 0.2097
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0108 0.0177
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0218 0.2883
Echinococcus multilocularis ets variant gene 4 0.0011 0.0023 0.0023
Brugia malayi Cathepsin L-like precursor 0.0018 0.0097 0.0341
Trypanosoma brucei heat shock protein, putative 0.0037 0.0297 0.4161
Echinococcus multilocularis expressed conserved protein 0.0108 0.1059 0.1059
Plasmodium falciparum mitogen-activated protein kinase 2 0.0342 0.3548 0.3744
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0451
Loa Loa (eye worm) hypothetical protein 0.0063 0.0583 0.2044
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0707 0.1376
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0411 0.0822
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0108 0.1284
Brugia malayi DKFZp564C0469 protein 0.0011 0.0031 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0203 0.2666
Onchocerca volvulus 0.003 0.0225 0.1385
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0266 0.0932
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0031 0.0117
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0342 0.3548 0.5643
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0628 0.8874
Echinococcus multilocularis cpg binding protein 0.0035 0.0286 0.0286
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0477 0.1672
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0255 0.3554
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.002 0.0209
Brugia malayi Endoplasmin precursor 0.0037 0.0297 0.1043
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0035 0.0215
Loa Loa (eye worm) hypothetical protein 0.0115 0.1133 0.3976
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0029 0.0218 0.9651
Loa Loa (eye worm) hypothetical protein 0.0075 0.0707 0.248
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0225 0.3128
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Onchocerca volvulus 0.0018 0.0097 0.0474
Loa Loa (eye worm) hypothetical protein 0.0028 0.0203 0.0713
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0097 0.0097
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0006 0.0011
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0342 0.3548 0.3744
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0255 0.3554
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0478 0.0956
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0203 0.2666
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2161 0.2161
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Loa Loa (eye worm) hypothetical protein 0.0063 0.0584 0.2048
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0097 0.0341
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0411 0.0822
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Echinococcus multilocularis protein patched 0.0049 0.0434 0.0434
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0108 0.0177
Onchocerca volvulus 0.003 0.0225 0.1385
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0607 0.8572
Echinococcus granulosus expressed conserved protein 0.0108 0.1059 0.2119
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Echinococcus granulosus General substrate transporter 0.0182 0.1844 0.3689
Echinococcus multilocularis geminin 0.0372 0.3875 0.3875
Brugia malayi Fli-1 protein 0.0225 0.2304 0.8081
Echinococcus granulosus dna polymerase kappa 0.0043 0.0366 0.0733
Onchocerca volvulus 0.003 0.0225 0.1385
Trypanosoma brucei heat shock protein, putative 0.0037 0.0297 0.4161
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0031 0.0108
Schistosoma mansoni heat shock protein 0.0037 0.0297 0.0595
Schistosoma mansoni protein kinase 0.0065 0.0598 0.1196
Schistosoma mansoni ets-related 0.0011 0.0023 0.0045
Brugia malayi Cathepsin L-like precursor 0.0012 0.0035 0.0122
Schistosoma mansoni heat shock protein 0.0015 0.0068 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0108 0.0177
Schistosoma mansoni rab6-interacting 0.0019 0.0112 0.0223
Toxoplasma gondii ABC1 family protein 0.0075 0.0707 0.1098
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.002 0.0068
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0225 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0035 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0707 0.3254
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0707 0.1376
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0035 0.0123
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0225 0.045
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0607 0.8572
Brugia malayi hypothetical protein 0.0011 0.0031 0.0108
Echinococcus granulosus cysteine protease 0.0009 0.0006 0.0011
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0015 0.0068 0.0135
Schistosoma mansoni topbp1 0.0011 0.0031 0.0062
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0411 0.5691
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0598 0.0626
Echinococcus granulosus endoplasmin 0.0029 0.0218 0.0436
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0707 0.248
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0108 0.0177
Onchocerca volvulus 0.003 0.0225 0.1385
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0023 0.0045
Schistosoma mansoni rab6-interacting 0.0019 0.0112 0.0223
Brugia malayi hypothetical protein 0.0276 0.2851 1
Entamoeba histolytica hypothetical protein 0.0047 0.0411 0.3595
Schistosoma mansoni ets-related 0.0225 0.2304 0.4609
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0108 0.1284
Brugia malayi heat shock protein 90 0.0037 0.0297 0.1043
Plasmodium vivax endoplasmin, putative 0.0037 0.0297 0.0308
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0297 0.4161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0707 0.1414
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0203 0.0367
Loa Loa (eye worm) beta-lactamase 0.0075 0.0707 0.248
Onchocerca volvulus 0.0018 0.0097 0.0474
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0411 0.5781
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0023 0.0023
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0108 0.1284
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0032 0.0019
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0122
Leishmania major glucose transporter, lmgt3 0.0066 0.0607 0.8542
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0031 0.0117
Schistosoma mansoni hypothetical protein 0.0053 0.0477 0.0954
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0045
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0218 0.0987
Mycobacterium tuberculosis Conserved protein 0.0075 0.0707 0.1376
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0209
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0031 0.0359
Onchocerca volvulus 0.003 0.0225 0.1385
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0598 0.0626
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0411 0.0411
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0117 0.0193
Brugia malayi major facilitator superfamily protein 0.003 0.0225 0.0789
Onchocerca volvulus 0.0018 0.0097 0.0474
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0451
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0108 0.1466
Schistosoma mansoni hypothetical protein 0.0053 0.0477 0.0954
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0474 0.6678
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0696 0.073
Trypanosoma brucei sugar transporter, putative 0.003 0.0225 0.3128
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0696 0.9844
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.1196
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.1196
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0366 0.5037
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0707 1
Brugia malayi MH2 domain containing protein 0.0126 0.1255 0.4403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Brugia malayi Calcitonin receptor-like protein seb-1 0.0169 0.1705 0.5979
Brugia malayi cathepsin L-like precursor 0.0012 0.0035 0.0122
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0203 0.2666
Brugia malayi Cathepsin L-like precursor 0.0018 0.0097 0.0341
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0411 0.0625
Schistosoma mansoni cpg binding protein 0.0035 0.0286 0.0572
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0138 0.1888
Echinococcus multilocularis endoplasmin 0.0029 0.0218 0.0218
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0707 0.1376
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.1196
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.1133 0.3976
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0598 0.8446
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0093 0.1248
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0023 0.0045
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0434 0.0434
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0108 0.0217
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0411 0.5691
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0297 0.4161
Brugia malayi Cathepsin L-like precursor 0.0012 0.0035 0.0122
Loa Loa (eye worm) hypothetical protein 0.0049 0.0434 0.1522
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0584 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0203 0.1753
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0108
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0023 0.0023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0169 0.1705 0.5979
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0225 0.1018
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0035 0.0122
Plasmodium falciparum heat shock protein 90 0.0037 0.0297 0.0308
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0035 0.0215
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Trypanosoma cruzi glucose transporter, putative 0.003 0.0225 0.3128
Schistosoma mansoni sugar transporter 0.003 0.0225 0.045
Onchocerca volvulus 0.003 0.0225 0.1385
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0097 0.0097
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0129 0.2575
Trypanosoma cruzi hexose transporter, putative 0.0036 0.029 0.4057
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0225 0.0789
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0129 0.0217
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0598 0.0626
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0031 0.0359
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0584 0.2048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Leishmania major cathepsin L-like protease 0.0068 0.0628 0.885
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.007 0.0568
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0097 0.0425
Mycobacterium tuberculosis Conserved protein 0.0075 0.0707 0.1376
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0366 0.5141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0029 0.0218 0.2883
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0203 0.0713
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0097 0.0425
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0203 0.2666
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0555 0.0555
Brugia malayi Cathepsin L-like precursor 0.0018 0.0097 0.0341
Trypanosoma cruzi hexose transporter, putative 0.003 0.0225 0.3128
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0707 0.1376
Treponema pallidum threonyl-tRNA synthetase 0.0012 0.0035 0.0225
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0097 0.112
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0225 0.0232
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0707 0.3254
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0628 0.8874
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0203 0.0367
Brugia malayi beta-lactamase 0.0075 0.0707 0.248
Echinococcus granulosus RUN 0.0019 0.0112 0.0223
Schistosoma mansoni elf1 0.0011 0.0023 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0006 0.0011
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0031 0.0117
Mycobacterium tuberculosis Conserved protein 0.0075 0.0707 0.1376
Brugia malayi Ets-domain containing protein 0.0074 0.0697 0.2446
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Onchocerca volvulus 0.0034 0.0266 0.1675
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0203 0.0713
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trypanosoma brucei heat shock protein, putative 0.0037 0.0297 0.4161
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.007 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0097 0.0425
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0707 0.0707
Schistosoma mansoni gabp alpha 0.0074 0.0697 0.1395
Toxoplasma gondii Hsp90 domain-containing protein 0.0015 0.0068 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0108
Mycobacterium leprae putative cytochrome p450 0.0019 0.0108 0.1284
Plasmodium falciparum protein kinase 7 0.0597 0.6273 0.6622
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0225 0.2981
Schistosoma mansoni lipoxygenase 0.0053 0.0478 0.0956
Echinococcus multilocularis cysteine protease 0.0018 0.0097 0.0097
Echinococcus multilocularis nibrin 0.0011 0.0031 0.0031
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0598 0.2097
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0097 0.0194
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2161 0.2161
Schistosoma mansoni glucose transporter 0.003 0.0225 0.045
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0203 0.2666
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.0218 0.0397
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.0108 0.1284
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0035 0.007
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.0108 0.1284
Onchocerca volvulus 0.0018 0.0097 0.0474
Trypanosoma brucei glucose transporter, putative 0.0066 0.0607 0.8572
Schistosoma mansoni hypothetical protein 0.0048 0.0415 0.083
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Schistosoma mansoni hypothetical protein 0.0019 0.0108 0.0217
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0097 0.0194
Echinococcus granulosus nibrin 0.0011 0.0031 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0349 0.1594
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0031 0.0117
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0218 0.0987
Brugia malayi Sugar transporter family protein 0.003 0.0225 0.0789
Leishmania major cathepsin L-like protease 0.0018 0.0097 0.112
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0112 0.0223
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0112 0.0112
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0006 0.0011
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Plasmodium vivax heat shock protein, putative 0.0015 0.0068 0.0066
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0584 0.0584
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0017 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0023 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0097 0.0425
Loa Loa (eye worm) fli-1 protein 0.0225 0.2304 0.8081
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0112 0.0112
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0203 0.1753
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0097 0.0474
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0035 0.0069
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0707 0.1376
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0225 0.1018
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0108 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0607 0.279
Treponema pallidum heat shock protein 90 0.0029 0.0218 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.032 0.1124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Trypanosoma cruzi sugar transporter, putative 0.003 0.0225 0.3128
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0186 0.0651
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0035 0.0261
Loa Loa (eye worm) sugar transporter 0.0211 0.2161 0.7579
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0023 0.008
Schistosoma mansoni ets 0.0011 0.0023 0.0045
Schistosoma mansoni hypothetical protein 0.0048 0.0415 0.083
Plasmodium vivax hexose transporter 0.0211 0.2161 0.2278
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0731 0.0731
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0108 0.0177
Echinococcus granulosus cathepsin l1 0.0018 0.0097 0.0194
Echinococcus granulosus dna polymerase eta 0.0015 0.007 0.0139
Loa Loa (eye worm) hypothetical protein 0.0047 0.0411 0.1442
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0225 0.0789
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0031 0.0062
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0696 0.1081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2161 0.2161
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0031 0.0117
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0297 0.2588
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0297 0.4161
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.007 0.0914
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0697 0.1395
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0035 0.007
Trypanosoma cruzi heat shock protein, putative 0.0015 0.0068 0.0886
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0218 0.3031
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0411 0.0428
Onchocerca volvulus 0.0075 0.0707 0.4823
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0117 0.0193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0097 0.0425
Trypanosoma brucei unspecified product 0.0036 0.0293 0.4092
Trypanosoma brucei heat shock protein 84, putative 0.0015 0.0068 0.0886
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0225 0.041
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0097 0.0474
Entamoeba histolytica protein kinase, putative 0.0065 0.0598 0.5253
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0244
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2161 0.4323
Loa Loa (eye worm) hypothetical protein 0.0075 0.0707 0.248
Trypanosoma brucei heat shock protein, putative 0.0037 0.0297 0.4161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0392
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0203 0.2666
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0584 0.1168
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0108 0.0177
Brugia malayi Cytochrome P450 family protein 0.0019 0.0108 0.038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0019 0.0038
Onchocerca volvulus 0.003 0.0225 0.1385
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Leishmania major cytochrome p450-like protein 0.0019 0.0108 0.1284
Trypanosoma brucei heat shock protein, putative 0.0037 0.0297 0.4161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0411 0.1442
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0108
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.2851 0.5704
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0031 0.0117
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0307 0.1078
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0225 0.045
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0023 0.008
Echinococcus multilocularis dnaJ subfamily B 0.0478 0.4999 0.4999
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0584 0.2684
Loa Loa (eye worm) ctsf protein 0.0018 0.0097 0.0341
Plasmodium vivax vivapain-2 0.0018 0.0097 0.0097
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0031 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0225 0.1018
Brugia malayi Cytochrome P450 family protein 0.0037 0.0307 0.1078
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0031 0.0117
Trypanosoma brucei heat shock protein, putative 0.0037 0.0297 0.4161
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0108 0.0141
Trypanosoma brucei glucose transporter, putative 0.0066 0.0607 0.8572
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0598 0.2097
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0335 0.0631
Leishmania major cathepsin L-like protease 0.0018 0.0097 0.112
Schistosoma mansoni sugar transporter 0.003 0.0225 0.045
Schistosoma mansoni topbp1 0.0011 0.0031 0.0062
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.007 0.0139
Trypanosoma brucei glucose transporter, putative 0.0066 0.0607 0.8572
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0031 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0707 1
Mycobacterium ulcerans lipase LipD 0.0075 0.0707 1
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0068 0.0066
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0108 0.0177
Toxoplasma gondii heat shock protein 75, putative 0.0015 0.0068 0.0076
Loa Loa (eye worm) hypothetical protein 0.0115 0.1136 0.3985
Onchocerca volvulus 0.003 0.0225 0.1385
Loa Loa (eye worm) hypothetical protein 0.0053 0.0477 0.1672
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0307 0.4305
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0203 0.2666
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.002 0.0209
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0108 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0225 0.1018
Brugia malayi transcription factor E74 isoform 0.0011 0.0023 0.008
Echinococcus multilocularis cysteine protease 0.0018 0.0097 0.0097
Echinococcus granulosus cpg binding protein 0.0035 0.0286 0.0572
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0117 0.1152 0.2306
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0031 0.0359
Schistosoma mansoni hypothetical protein 0.0056 0.0508 0.1017
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0108 0.1284
Schistosoma mansoni protein kinase 0.0065 0.0598 0.1196
Schistosoma mansoni glucose transport protein 0.0211 0.2161 0.4323
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0585 0.0904
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0035 0.0035
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0031 0.0108
Loa Loa (eye worm) hypothetical protein 0.0028 0.0203 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0031 0.0117
Echinococcus multilocularis 0.0019 0.0108 0.0108
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0293 0.4092
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0097 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Trichomonas vaginalis esterase, putative 0.0075 0.0707 0.3254
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0225 0.1018
Giardia lamblia Glycyl-tRNA synthetase 0.0012 0.0035 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0203 0.1753
Schistosoma mansoni loxhd1 0.0019 0.0112 0.0223
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0297 0.4161
Schistosoma mansoni hypothetical protein 0.0372 0.3875 0.7752
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0097 0.0194
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0108 0.1284
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0434 0.0868
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0598
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0108 0.0177
Brugia malayi beta-lactamase family protein 0.0075 0.0707 0.248
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0598
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0307 0.1078
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0376
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0035 0.0419
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0307 0.1078
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0307 0.4305
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0068 0.0066
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0108 0.1284
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0143 0.1433 0.5026
Schistosoma mansoni DNA polymerase eta 0.0015 0.007 0.0139
Schistosoma mansoni hypothetical protein 0.0115 0.1136 0.2273
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0411 0.5691
Onchocerca volvulus 0.0018 0.0097 0.0474
Echinococcus multilocularis heat shock protein 90 0.0029 0.0218 0.0218
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0696 0.9841
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0225 0.2981
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Onchocerca volvulus 0.003 0.0225 0.1385
Entamoeba histolytica cysteine protease, putative 0.0018 0.0097 0.0812
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0218 0.0436
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0598 0.1196
Schistosoma mansoni cpg binding protein 0.0035 0.0286 0.0572
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0707 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0108 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0707 0.3254
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0707 0.0741
Onchocerca volvulus 0.0075 0.0707 0.4823
Schistosoma mansoni DNA ligase IV 0.0011 0.0031 0.0062
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0147 0.3055
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0108 0.1284
Giardia lamblia Sugar-proton symporter 0.003 0.0225 0.351
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0108 0.1284
Toxoplasma gondii sugar transporter ST2 0.003 0.0225 0.0327
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0108 0.1466
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0451
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0035 0.007
Toxoplasma gondii facilitative glucose transporter GT1 0.0211 0.2161 0.3424
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0697 0.2446
Onchocerca volvulus 0.0018 0.0097 0.0474
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0225 0.0789
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0707 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0477 0.0954
Leishmania major DNA polymerase kappa, putative 0.0022 0.0143 0.1791
Schistosoma mansoni glucose transport protein 0.0211 0.2161 0.4323
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0031 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0108
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0411 0.6873
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0097 0.0097
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0598
Mycobacterium ulcerans beta-lactamase 0.0075 0.0707 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0203 0.2666
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0731 0.1463
Leishmania major cathepsin L-like protease 0.0068 0.0628 0.885
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0508 0.1783
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.002 0.0209
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0035 0.0419
Loa Loa (eye worm) hypothetical protein 0.0018 0.0097 0.0341
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0731 0.1463
Toxoplasma gondii sugar transporter ST3 0.003 0.0225 0.0327
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0598 0.2097
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0023 0.0023
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0225 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0696 0.9841
Echinococcus granulosus solute carrier family 22 0.003 0.0225 0.045
Entamoeba histolytica hypothetical protein 0.0077 0.0731 0.6434
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0584 0.2048
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0035 0.003
Leishmania major protein kinase, putative 0.0065 0.0598 0.8413
Onchocerca volvulus 0.0018 0.0097 0.0474
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0203 0.2666
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0225 0.2981
Mycobacterium ulcerans sugar transporter 0.003 0.0225 0.2981
Onchocerca volvulus 0.003 0.0225 0.1385
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0015 0.0068 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.1133 0.1133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Mycobacterium leprae Probable lipase LipE 0.0075 0.0707 1
Schistosoma mansoni lipoxygenase 0.0019 0.0112 0.0223
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0108 0.1284
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0108 0.0177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0666 0.1333
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0035 0.0261
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0108 0.1284
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0218 0.3031
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0297 0.482
Echinococcus granulosus protein C ets 2 0.0011 0.0023 0.0045
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2161 0.4323
Echinococcus granulosus GPCR family 2 0.0053 0.0477 0.0954
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0097 0.0474
Loa Loa (eye worm) hypothetical protein 0.0065 0.0598 0.2097
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0031 0.0223
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0097 0.0097
Brugia malayi CHE-14 protein 0.0049 0.0434 0.1522
Leishmania major heat shock protein 83-1 0.0037 0.0297 0.4037
Schistosoma mansoni hypothetical protein 0.0478 0.4999 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0897 0.9469 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0097 0.0425
Echinococcus granulosus Niemann Pick C1 protein 0.0164 0.1659 0.3319
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1255 0.4403
Loa Loa (eye worm) hypothetical protein 0.0169 0.1705 0.5979
Onchocerca volvulus 0.003 0.0225 0.1385
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.007 0.0139
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0035 0.0031
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0598 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.002 0.0068
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0297 0.1354
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0203 0.2666
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0707 0.1414
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0112 0.0112
Plasmodium vivax heat shock protein 90, putative 0.0015 0.0068 0.0066
Chlamydia trachomatis threonine--tRNA ligase 0.0012 0.0035 0.0111
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0108 0.1284
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0307 0.4183
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0707 0.1414
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0366 0.5141
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0707 0.248
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0147 0.1845
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0035 0.0031
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.1133 0.2268
Schistosoma mansoni glucose transport protein 0.0211 0.2161 0.4323
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0628 0.8874
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0297 0.1043
Loa Loa (eye worm) hypothetical protein 0.006 0.0552 0.1937
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0031 0.0359
Echinococcus granulosus cathepsin L 0.0009 0.0006 0.0011
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2161 0.4323
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0147 0.0656
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0707 1
Schistosoma mansoni heat shock protein 0.0037 0.0297 0.0595
Echinococcus granulosus heat shock protein 0.0037 0.0297 0.0595
Schistosoma mansoni hypothetical protein 0.0077 0.0731 0.1463
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0211 0.2161 0.2161
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0045
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0335 0.0631
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0607 0.279
Loa Loa (eye worm) hypothetical protein 0.0143 0.1433 0.5026
Loa Loa (eye worm) hypothetical protein 0.0075 0.0707 0.248
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0297 0.4161
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0035 0.0024
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0366 0.5037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0203 0.2666
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0108 0.1466
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0434 0.1522
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0607 0.279
Schistosoma mansoni polycystin 1-related 0.0019 0.0112 0.0223
Echinococcus multilocularis protein dispatched 1 0.0056 0.0508 0.0508
Onchocerca volvulus 0.003 0.0225 0.1385
Echinococcus multilocularis dna polymerase eta 0.0015 0.007 0.007
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0023 0.0045
Leishmania major heat shock protein, putative 0.0015 0.0068 0.0692
Onchocerca volvulus 0.0019 0.0112 0.0577
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0019 0.0112 0.0223
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0478 0.0478
Echinococcus multilocularis cathepsin L 0.0009 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Brugia malayi hypothetical protein 0.003 0.0225 0.0789
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0112 0.0223
Echinococcus granulosus dnaJ subfamily B 0.0478 0.4999 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0169 0.1705 0.5979
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0297 0.0443
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0108 0.1284
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0023 0.0023
Leishmania major cytochrome p450-like protein 0.0037 0.0307 0.4183
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0411 0.0428
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0108 0.1284
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0023 0.008
Brugia malayi major facilitator superfamily protein 0.003 0.0225 0.0789
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0093 0.1248
Trypanosoma brucei glucose transporter, putative 0.0066 0.0607 0.8572
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0555 0.1111
Trichomonas vaginalis glucose transporter, putative 0.003 0.0225 0.1018
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1255 0.4403
Onchocerca volvulus 0.0019 0.0112 0.0577
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0108
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0012 0.0035 0.0217
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0477 0.0477
Onchocerca volvulus Huntingtin homolog 0.0143 0.1433 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0097 0.0097
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0031 0.0027
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0035 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0097 0.0425
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0203 0.2666
Brugia malayi hypothetical protein 0.003 0.0225 0.0789
Leishmania major glucose transporter, lmgt1 0.0066 0.0607 0.8542
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Schistosoma mansoni hypothetical protein 0.0048 0.0415 0.083
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0108 0.0177
Schistosoma mansoni endoplasmin 0.0037 0.0297 0.0595
Trypanosoma brucei glucose transporter, putative 0.0066 0.0607 0.8572
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0607 0.279
Loa Loa (eye worm) hypothetical protein 0.0052 0.0457 0.1604
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0584 0.5129
Loa Loa (eye worm) hypothetical protein 0.0075 0.0707 0.248
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0123
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0789
Brugia malayi hypothetical protein 0.0143 0.1433 0.5026
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.007 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0209
Brugia malayi cytochrome P450 0.0019 0.0108 0.038
Brugia malayi Cytochrome P450 family protein 0.0037 0.0307 0.1078
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.008
Schistosoma mansoni hypothetical protein 0.0211 0.2161 0.4323
Schistosoma mansoni survival motor neuron protein 0.0056 0.0508 0.1017
Schistosoma mansoni endoplasmin 0.0037 0.0297 0.0595
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0477 0.1672
Echinococcus multilocularis General substrate transporter 0.0182 0.1844 0.1844
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0598 0.2749
Brugia malayi hypothetical protein 0.0077 0.0731 0.2565
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0093 0.1248
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0707 0.1376
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0031 0.0117
Loa Loa (eye worm) cysteine protease 0.0018 0.0097 0.0341
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0097 0.0812
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0696 0.9844
Echinococcus granulosus heat shock protein 90 0.0037 0.0297 0.0595
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Onchocerca volvulus 0.003 0.0225 0.1385
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0697 0.0697
Brugia malayi Sugar transporter family protein 0.003 0.0225 0.0789
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0451
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2161 0.4323
Giardia lamblia Threonyl-tRNA synthetase 0.0012 0.0035 0.0076
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0477 0.1672
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0607 0.8542
Echinococcus multilocularis GPCR, family 2 0.0053 0.0477 0.0477
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.1133 1
Brugia malayi Cytochrome P450 family protein 0.0039 0.032 0.1124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0628 0.8874
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0707 0.1376
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0434 0.0868
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0129 0.013
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0031 0.0017
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0225 0.0789
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0598 0.0626
Echinococcus granulosus solute carrier family 22 0.003 0.0225 0.045
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0598 0.0925
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0225 0.0225
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0598
Brugia malayi hypothetical protein 0.003 0.0225 0.0789
Brugia malayi Cathepsin L-like precursor 0.0018 0.0097 0.0341
Brugia malayi polk-prov protein 0.0033 0.0255 0.0894
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0035 0.0024
Leishmania major cathepsin L-like protease 0.0018 0.0097 0.112
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0143 0.1962
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0607 0.8572
Echinococcus granulosus cathepsin l1 0.0012 0.0035 0.0069
Loa Loa (eye worm) hypothetical protein 0.0276 0.2851 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0707 0.3254
Loa Loa (eye worm) sugar transporter 0.003 0.0225 0.0789
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0035 0.0031
Trichomonas vaginalis sugar transporter, putative 0.003 0.0225 0.1018
Leishmania major hypothetical protein, conserved 0.003 0.0225 0.2981
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0112 0.0392
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.007 0.0244
Leishmania major DNA polymerase eta, putative 0.0015 0.007 0.072
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0411 0.1881
Onchocerca volvulus 0.003 0.0225 0.1385
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0707 1
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0023 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0607 0.279
Plasmodium vivax sugar transporter, putative 0.003 0.0225 0.0232
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0015 0.0068 0.0551
Echinococcus granulosus heat shock protein 90 0.0029 0.0218 0.0436
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0297 0.0308
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0129 0.158
Brugia malayi topoisomerase 0.0011 0.0031 0.0108
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0097 0.0097
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0031 0.0031
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0108 0.1284
Brugia malayi hypothetical protein 0.0011 0.0031 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0097 0.0425
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0477 0.0477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0097 0.0425
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0584 0.1168
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.007 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Schistosoma mansoni cytochrome P450 0.0019 0.0108 0.0217
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0035 0.0123
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0225 0.1018
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0366 0.5141
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0108 0.0177

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 1.52 10'-5M Cytotoxicity against human SKBR3 cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 1.56 10'-5M Cytotoxicity against human doxorubicin resistant LoVo cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 1.63 10'-5M Cytotoxicity against human LoVo cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 1.93 10'-5M Cytotoxicity against human HT29 cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 5.3 10'-6M Cytotoxicity against human LNcaP cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 7.41 10'-6M Cytotoxicity against human A549 cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 7.48 10'-6M Cytotoxicity against human DU145 cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 7.58 10'-6M Cytotoxicity against human SK-MEL-28 cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 7.69 10'-6M Cytotoxicity against human HeLa cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 8.78 10'-6M Cytotoxicity against human PANC1 cells after 48 hrs by SRB assay ChEMBL. 18672864
GI50 (functional) = 9.64 10'-6M Cytotoxicity against human K562 cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 1.04 10'-6M Cytotoxicity against human SKBR3 cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 1.35 10'-6M Cytotoxicity against human HeLa cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 1.37 10'-6M Cytotoxicity against human LNcaP cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 1.66 10'-6M Cytotoxicity against human DU145 cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 1.79 10'-6M Cytotoxicity against human A549 cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 1.82 10'-6M Cytotoxicity against human SK-MEL-28 cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 1.89 10'-6M Cytotoxicity against human K562 cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 2.27 10'-6M Cytotoxicity against human PANC1 cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 2.33 10'-6M Cytotoxicity against human HT29 cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 3.67 10'-6M Cytotoxicity against human doxorubicin resistant LoVo cells after 48 hrs by SRB assay ChEMBL. 18672864
LC50 (functional) = 3.86 10'-6M Cytotoxicity against human LoVo cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 2.7 10'-6M Cytotoxicity against human LNcaP cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 3.23 10'-6M Cytotoxicity against human HeLa cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 3.53 10'-6M Cytotoxicity against human DU145 cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 3.64 10'-6M Cytotoxicity against human A549 cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 3.73 10'-6M Cytotoxicity against human SK-MEL-28 cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 3.77 10'-6M Cytotoxicity against human K562 cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 4.47 10'-6M Cytotoxicity against human PANC1 cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 6.24 10'-6M Cytotoxicity against human SKBR3 cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 7.58 10'-6M Cytotoxicity against human doxorubicin resistant LoVo cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 7.93 10'-6M Cytotoxicity against human LoVo cells after 48 hrs by SRB assay ChEMBL. 18672864
TGI (functional) = 8.7 10'-6M Cytotoxicity against human HT29 cells after 48 hrs by SRB assay ChEMBL. 18672864

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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