Detailed information for compound 1181770

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 722.602 | Formula: C35H30O17
  • H donors: 10 H acceptors: 13 LogP: 2.66 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 4
  • SMILES: O[C@H]1[C@H](Oc2cc(O)c(c(c2)O)C(=O)CCc2ccccc2)O[C@H]2[C@H]([C@@H]1O)OC(=O)c1cc(O)c(c(c1c1c(C(=O)OC2)cc(c(c1O)O)O)O)O
  • InChi: 1S/C35H30O17/c36-17(7-6-13-4-2-1-3-5-13)25-18(37)8-14(9-19(25)38)50-35-31(46)30(45)32-22(51-35)12-49-33(47)15-10-20(39)26(41)28(43)23(15)24-16(34(48)52-32)11-21(40)27(42)29(24)44/h1-5,8-11,22,30-32,35,37-46H,6-7,12H2/t22-,30-,31-,32-,35-/m1/s1
  • InChiKey: UJNCWORGHSATHA-XWSAIMBSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus NS3 protease/helicase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei gambiense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium vivax RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Theileria parva RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Treponema pallidum ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium berghei eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium knowlesi eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium parvum eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Onchocerca volvulus Eukaryotic initiation factor 4A homolog Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium hominis eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-III, putative Get druggable targets OG5_126984 All targets in OG5_126984
Babesia bovis eukaryotic translation initiation factor 4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Toxoplasma gondii eukaryotic initiation factor-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Giardia lamblia Translation initiation factor eIF-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium yoelii RNA helicase-1 Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum ATP-dependent RNA helicase eIF4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma congolense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Neospora caninum DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium falciparum eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-II, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania mexicana Get druggable targets OG5_126984 All targets in OG5_126984
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0027 0.0044
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0027 0.0048
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0074 0.0074
Brugia malayi phosphofructokinase 0.0114 0.0235 0.0412
Schistosoma mansoni hypothetical protein 0.0048 0.0074 0.013
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0029 0.005
Onchocerca volvulus Protein ultraspiracle homolog 0.0072 0.0131 0.0924
Echinococcus multilocularis ubiquitin specific protease 41 0.0194 0.0428 0.0428
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0045 0.0066 0.0868
Brugia malayi Cytochrome P450 family protein 0.011 0.0224 0.0393
Brugia malayi nuclear receptor NHR-67 0.0034 0.0039 0.0069
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0235 0.0412
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0235 0.3184
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0056 0.0098
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0877 0.209 0.3668
Echinococcus multilocularis zinc finger protein 0.0028 0.0025 0.0025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0072 0.0131 0.0231
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0072 0.0131 0.0131
Plasmodium falciparum thioredoxin reductase 0.0048 0.0074 1
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0056 0.0098
Brugia malayi Bromodomain containing protein 0.0087 0.0169 0.0297
Entamoeba histolytica hypothetical protein 0.0229 0.0515 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0056 0.0098
Brugia malayi Cytochrome P450 family protein 0.0045 0.0066 0.0116
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0045 0.0066 0.0111
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.011 0.011
Loa Loa (eye worm) cytochrome P450 0.0045 0.0066 0.0116
Schistosoma mansoni hypothetical protein 0.0045 0.0066 0.0116
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0877 0.209 0.3668
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0008 0.0008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.002 0.0157
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0235 0.2025
Plasmodium falciparum eukaryotic initiation factor 4A 0.003 0.0029 0.3644
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0049 0.0086
Loa Loa (eye worm) hypothetical protein 0.0072 0.0131 0.0231
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.0258 0.0449
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0064 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0367 0.3179
Echinococcus granulosus jumonji domain containing protein 0.004 0.0055 0.0097
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0074 0.013
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.0224 0.0393
Schistosoma mansoni transcription factor LCR-F1 0.0229 0.0515 0.0905
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0229 0.0515 0.0905
Brugia malayi Protein kinase domain containing protein 0.0556 0.1309 0.2299
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.014 0.0246
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0194 0.0428 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0367 0.3179
Brugia malayi nuclear hormone receptor 0.0072 0.0131 0.0231
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0039 0.0069
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0045 0.0066 0.0868
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0367 0.3179
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0556 0.1309 0.2299
Loa Loa (eye worm) glutaminase 0.0315 0.0723 0.1271
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0582 0.1023
Onchocerca volvulus 0.0061 0.0105 0.0692
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0039 0.0069
Trichomonas vaginalis glutaminase, putative 0.0315 0.0723 0.6278
Echinococcus granulosus FTZ F1 alpha 0.0072 0.0131 0.0231
Echinococcus multilocularis eukaryotic initiation factor 4A 0.003 0.0029 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0582 0.5051
Brugia malayi PHD-finger family protein 0.0034 0.0039 0.0068
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0131 0.0231
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0072 0.0131 0.0231
Brugia malayi Steroid receptor seven-up type 2 0.0072 0.0131 0.0231
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0131 0.0231
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0045 0.0066 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0045 0.0066 0.0868
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0072 0.0131 0.0231
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0045 0.0066 0.0868
Giardia lamblia PHD finger protein 15 0.0029 0.0027 0.0353
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0086
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0024 0.0042
Brugia malayi glutathione reductase 0.0048 0.0074 0.0131
Brugia malayi hypothetical protein 0.0038 0.0049 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0072 0.0131 0.0231
Brugia malayi ecdysone receptor 0.0034 0.0039 0.0069
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0045 0.0066 0.0868
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0235 0.0412
Loa Loa (eye worm) CYP4Cod1 0.011 0.0224 0.0393
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0131 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0049 0.0086
Loa Loa (eye worm) hypothetical protein 0.005 0.0078 0.0137
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0039 0.0069
Brugia malayi Cytochrome P450 family protein 0.011 0.0224 0.0393
Echinococcus multilocularis FTZ F1 alpha 0.0072 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0059 0.0491
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0039 0.0069
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0255 0.3463
Echinococcus multilocularis ecdysone induced protein 78C 0.0072 0.0131 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0582 0.5051
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0305 0.0536
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.003 0.0029 0.0046
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0049 0.0049
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.031 0.0711 0.1245
Echinococcus granulosus peregrin 0.0035 0.0042 0.0074
Schistosoma mansoni tyrosine kinase 0.0925 0.2206 0.3876
Brugia malayi nuclear receptor NHR-88 0.0072 0.0131 0.0231
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0072 0.0131 0.0231
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0039 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0045 0.0066 0.0868
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0131 0.0231
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0271 0.3687
Mycobacterium ulcerans glutaminase 0.0315 0.0723 0.988
Echinococcus multilocularis GPCR, family 2 0.0034 0.0039 0.0039
Onchocerca volvulus 0.0491 0.1151 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.011 0.0194
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0032 0.0052
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0277 0.0487
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0049 0.0909
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0157
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.0271 0.3687
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0072 0.0131 0.0131
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.031 0.0711 0.1245
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0045 0.0066 0.0868
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0155 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0131 0.0231
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0049 0.6472
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0039 0.0069
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0027 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0045 0.0066 0.0868
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0045 0.0066 0.0868
Loa Loa (eye worm) hypothetical protein 0.0072 0.0131 0.0231
Onchocerca volvulus 0.0075 0.014 0.1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0049 0.0658
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0066 0.0346
Loa Loa (eye worm) glutathione reductase 0.0048 0.0074 0.0131
Loa Loa (eye worm) hypothetical protein 0.0154 0.0332 0.0583
Echinococcus granulosus fructose 16 bisphosphatase 1 0.2358 0.5692 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0157
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0045 0.0066 0.0868
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0032 0.0259
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0271 0.3687
Brugia malayi photoreceptor-specific nuclear receptor 0.0072 0.0131 0.0231
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0039 0.0039
Giardia lamblia Translation initiation factor eIF-4A, putative 0.003 0.0029 0.0371
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0018 0.2147
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0305 0.0305
Echinococcus granulosus eukaryotic initiation factor 4A 0.003 0.0029 0.005
Schistosoma mansoni nuclear receptor 0.0034 0.0039 0.0069
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0188 0.0331
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0194 0.0428 0.0752
Echinococcus multilocularis geminin 0.1047 0.2505 0.2505
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0072 0.0131 0.0231
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0029 0.0231
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0129 0.0129
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0018 0.2147
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0125
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0556 0.1309 0.1309
Echinococcus granulosus cpg binding protein 0.0066 0.0119 0.0208
Leishmania major cytochrome p450-like protein 0.0045 0.0066 0.0111
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0235 0.0235
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0255 1
Brugia malayi Thioredoxin reductase 0.0048 0.0074 0.0131
Brugia malayi ecdysteroid receptor 0.0072 0.0131 0.0231
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0138 0.0243
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0045 0.0066 0.0868
Schistosoma mansoni cpg binding protein 0.0061 0.0105 0.0185
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0018 0.0027
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0064 0.0535
Loa Loa (eye worm) hypothetical protein 0.0236 0.053 0.0931
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.005 0.005
Brugia malayi hypothetical protein 0.0229 0.0515 0.0905
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0032 0.0052
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0039 0.0039
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0039 0.0104
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.003 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0029 0.0046
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0002 0.0004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0072 0.0131 0.0231
Brugia malayi jmjC domain containing protein 0.0095 0.0188 0.0331
Leishmania major 0.2358 0.5692 1
Brugia malayi follicle stimulating hormone receptor 0.0709 0.1681 0.2954
Trichomonas vaginalis CMGC family protein kinase 0.031 0.0711 0.617
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0072 0.0131 0.0231
Echinococcus granulosus insulin receptor 0.0556 0.1309 0.2299
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0072 0.0131 0.0231
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0319 0.0732 1
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0138 0.1186
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0131 0.0231
Echinococcus multilocularis mitogen activated protein kinase 3 0.031 0.0711 0.0711
Schistosoma mansoni tyrosine kinase 0.1739 0.4188 0.7357
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0055 0.0055
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0074 0.0987
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.0271 0.0473
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0018 0.0027
Schistosoma mansoni nuclear receptor 0.0034 0.0039 0.0069
Onchocerca volvulus 0.0034 0.0039 0.0104
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0064 0.0108
Loa Loa (eye worm) DR-78 0.0034 0.0039 0.0069
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0039 0.0104
Leishmania major trypanothione reductase 0.0048 0.0074 0.0127
Onchocerca volvulus 0.0034 0.0039 0.0104
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0045 0.0066 0.0868
Entamoeba histolytica hypothetical protein 0.0229 0.0515 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0217 0.0382
Trypanosoma brucei cytochrome P450, putative 0.011 0.0224 0.0389
Loa Loa (eye worm) hypothetical protein 0.0107 0.0217 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0021
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0072 0.0131 0.0231
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0039 0.0069
Giardia lamblia Kinase, CMGC MAPK 0.031 0.0711 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0032 0.2738
Schistosoma mansoni RAR-like nuclear receptor 0.0072 0.0131 0.0231
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0235 0.4532
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0019
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0008 0.0015
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.2358 0.5692 0.5692
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0045 0.0066 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0029 0.0233
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0101 0.0178
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0029 0.0046
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.053 0.053
Schistosoma mansoni chromobox protein 0.0075 0.0138 0.0243
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0032 0.2738
Loa Loa (eye worm) hypothetical protein 0.0042 0.0059 0.0103
Echinococcus multilocularis cpg binding protein 0.0066 0.0119 0.0119
Brugia malayi conserved hypotetical protein 0.0034 0.0039 0.0069
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0002 0.0004
Loa Loa (eye worm) acetyltransferase 0.0143 0.0305 0.0536
Entamoeba histolytica hypothetical protein 0.0229 0.0515 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0194 0.0428 0.6007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0008 0.0015
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0045 0.0066 0.0868
Echinococcus granulosus mitogen activated protein kinase 0.031 0.0711 0.1249
Loa Loa (eye worm) glutaminase 2 0.0315 0.0723 0.1271
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0225 0.3052
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0235 0.2025
Echinococcus granulosus mitogen activated protein kinase 3 0.031 0.0711 0.1249
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0039 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0027 0.2323
Echinococcus multilocularis muscleblind protein 0.0154 0.0332 0.0332
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0049 0.0086
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0032 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0157
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0064 0.0535
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0039 0.0069
Brugia malayi nuclear receptor RXR 0.0034 0.0039 0.0069
Brugia malayi hypothetical protein 0.0034 0.0039 0.0069
Loa Loa (eye worm) steroid hormone receptor 0.0072 0.0131 0.0231
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0032 0.1269
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0235 0.0408
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0039 0.0069
Brugia malayi nuclear hormone receptor 0.0034 0.0039 0.0069
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0045 0.0066 0.0868
Brugia malayi 6-phosphofructokinase 0.0114 0.0235 0.0412
Schistosoma mansoni tyrosine kinase 0.0934 0.223 0.3918
Trypanosoma cruzi cytochrome P450, putative 0.011 0.0224 0.0389
Brugia malayi hypothetical protein 0.0038 0.0049 0.0086
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0072 0.0131 0.0231
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0018 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0155 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0072 0.0131 0.0231
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0074 0.0127
Schistosoma mansoni hypothetical protein 0.0229 0.0515 0.0905
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0131 0.0231
Brugia malayi hypothetical protein 0.0034 0.0039 0.0069
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.031 0.0711 0.1245
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0289 0.0508
Echinococcus granulosus cytochrome P450 2K1 0.0045 0.0066 0.0116
Leishmania major cytochrome p450-like protein 0.0045 0.0066 0.0111
Entamoeba histolytica hypothetical protein 0.0229 0.0515 1
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0235 0.4532
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0039 0.0069
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.011 0.0224 0.3034
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0032 0.0052
Brugia malayi Bromodomain containing protein 0.0044 0.0065 0.0114
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Echinococcus multilocularis epidermal growth factor receptor 0.0934 0.223 0.223
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0045 0.0066 0.0868
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0045 0.0066 0.0868
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0022 0.0039
Loa Loa (eye worm) hypothetical protein 0.0053 0.0085 0.0149
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0235 0.0412
Trypanosoma cruzi cytochrome P450, putative 0.011 0.0224 0.0389
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0155 0.0272
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0029 0.0046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.002 0.0157
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0002 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0045 0.0066 0.0868
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0367 0.3179
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0032 0.0259
Leishmania major cytochrome p450-like protein 0.011 0.0224 0.0389
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0389 0.3371
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0045 0.0066 0.0868
Mycobacterium ulcerans epoxide hydrolase EphA 0.0319 0.0732 1
Echinococcus granulosus zinc finger protein 0.0028 0.0025 0.0043
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0235 0.0412
Echinococcus granulosus chromobox protein 1 0.0075 0.0138 0.0243
Brugia malayi hypothetical protein 0.0025 0.0018 0.0031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0217 0.0382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0072 0.0131 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0131 0.0231
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0039 0.0069
Echinococcus granulosus muscleblind protein 0.0154 0.0332 0.0583
Echinococcus granulosus ubiquitin specific protease 41 0.0194 0.0428 0.0752
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0072 0.0131 0.0131
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0194 0.0428 0.0752
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0072 0.0131 0.0231
Plasmodium vivax SET domain protein, putative 0.0063 0.011 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0225 0.3052
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0045 0.0066 0.0868
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0039 0.0069
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0018 0.0027
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0154 0.0332 0.0583
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0072 0.0131 0.0231
Brugia malayi nuclear receptor RXR 0.0038 0.0049 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0131 0.0231
Schistosoma mansoni tyrosine kinase 0.0556 0.1309 0.2299
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0032 0.4094
Onchocerca volvulus Huntingtin homolog 0.0256 0.0578 0.4904
Schistosoma mansoni survival motor neuron protein 0.0048 0.0074 0.013
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2358 0.5692 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0582 0.1023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0039 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0045 0.0066 0.0868
Schistosoma mansoni hypothetical protein 0.0073 0.0135 0.0237
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0024 0.0042
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0045 0.0066 0.0868
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0049 0.0086
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0039 0.0069
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0305 0.0536
Echinococcus granulosus epidermal growth factor receptor 0.1739 0.4188 0.7357
Onchocerca volvulus 0.0033 0.0037 0.0081
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0029 0.0231
Schistosoma mansoni serine/threonine protein kinase 0.031 0.0711 0.1249
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.0271 0.0477
Trichomonas vaginalis CMGC family protein kinase 0.031 0.0711 0.617
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0032 0.4094
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0235 0.3184
Brugia malayi Bromodomain containing protein 0.0035 0.0042 0.0074
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0029 0.005
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0045 0.0066 0.0868
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0064 0.5679
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0032 0.0259
Brugia malayi 6-phosphofructokinase 0.0114 0.0235 0.0412
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0039 0.0069
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0045 0.0066 0.0868
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0255 0.3463
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.011 0.0189
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.0069
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.031 0.0711 0.1249
Brugia malayi steroid hormone receptor 0.0072 0.0131 0.0231
Schistosoma mansoni tyrosine kinase 0.0934 0.223 0.3918
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0582 0.5051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0131 0.0231
Brugia malayi Furin-like cysteine rich region family protein 0.1739 0.4188 0.7357
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0074 0.0131
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0045 0.0066 0.0868
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.031 0.0711 0.1245
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0131 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0428 0.3707
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0072 0.0131 0.0231
Onchocerca volvulus Huntingtin homolog 0.0256 0.0578 0.4904
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.0271 0.0271
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0235 0.0412
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0582 0.5051
Echinococcus multilocularis 0.0538 0.1266 0.1266
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0194 0.0428 0.0748
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0105 0.0185
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0225 0.3052
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0045 0.0066 0.0868
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0135 0.0237
Loa Loa (eye worm) hypothetical protein 0.0073 0.0135 0.0237
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0255 0.3463
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0029 0.0046
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0225 0.3052
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0235 0.8925
Schistosoma mansoni coup transcription factor 0.0072 0.0131 0.0231
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0235 0.0408
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0582 0.5051
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0002 0.0002
Onchocerca volvulus 0.0072 0.0131 0.0924
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0194 0.0428 0.0428
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0024 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0032 0.0259
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0194 0.0428 0.8301
Brugia malayi CXXC zinc finger family protein 0.0061 0.0105 0.0185
Schistosoma mansoni cpg binding protein 0.0066 0.0119 0.0208
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0001 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0367 0.3179
Echinococcus granulosus geminin 0.1047 0.2505 0.4401
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0162 0.0284
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.0069
Schistosoma mansoni zinc finger protein 0.0034 0.0039 0.0069
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0032 0.0259
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0032 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0005 0.0021
Schistosoma mansoni peptidase 0.0018 0.0002 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.0271 0.0477
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0045 0.0066 0.0111
Schistosoma mansoni steroid hormone receptor ad4bp 0.0072 0.0131 0.0231
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0072 0.0131 0.0231
Echinococcus multilocularis mitogen activated protein kinase 0.031 0.0711 0.0711
Schistosoma mansoni tyrosine kinase 0.0925 0.2206 0.3876
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0039 0.0039
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0049 0.0086
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.003 0.0029 0.0011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0001 0.0002
Brugia malayi glutaminase DH11.1 0.0315 0.0723 0.1271
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0066 0.0559
Echinococcus multilocularis thyroid hormone receptor alpha 0.0072 0.0131 0.0131
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0877 0.209 0.3668
Schistosoma mansoni hypothetical protein 0.0029 0.0027 0.0048
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0235 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0045 0.0066 0.0868
Brugia malayi Cytochrome P450 family protein 0.0084 0.0162 0.0284
Brugia malayi chromobox protein homolog 3 0.0042 0.0059 0.0103
Brugia malayi tailless protein 0.0034 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0256 0.0578 0.1016
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.0271 0.0473
Leishmania major hypothetical protein, conserved 0.0025 0.0018 0.0027
Schistosoma mansoni bromodomain containing protein 0.0075 0.0139 0.0243
Trypanosoma brucei trypanothione reductase 0.0048 0.0074 0.0127
Mycobacterium tuberculosis Probable reductase 0.011 0.0225 0.3052
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0039 0.0069
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0042 0.0042
Schistosoma mansoni chromobox protein 0.0075 0.0138 0.0243
Schistosoma mansoni fructose-16-bisphosphatase-related 0.2358 0.5692 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0039 0.0069
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.2358 0.5692 1
Brugia malayi eukaryotic initiation factor 4A 0.003 0.0029 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0367 0.3179
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0049 0.0086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0031
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0002 0.5
Trichomonas vaginalis CMGC family protein kinase 0.031 0.0711 0.617
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0045 0.0066 0.0868
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0194 0.0428 0.0748
Onchocerca volvulus 0.0048 0.0074 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0059 0.0491
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0086
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0709 0.1681 0.2954
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0039 0.0069
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0027 0.0048
Schistosoma mansoni tyrosine kinase 0.0925 0.2206 0.3876
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0235 0.4532
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.031 0.0711 0.1245
Echinococcus multilocularis peregrin 0.0035 0.0042 0.0042
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0934 0.223 0.3918
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0194 0.0428 0.0752
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0131 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0131 0.0231
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0229 0.0515 0.0515
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0045 0.0066 0.0868
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0045 0.0066 0.0868
Echinococcus granulosus GPCR family 2 0.0034 0.0039 0.0069
Brugia malayi MAP kinase sur-1 0.031 0.0711 0.1249
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0027 0.0048
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.005 0.0089
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0064
Schistosoma mansoni cpg binding protein 0.0066 0.0119 0.0208
Plasmodium vivax glutathione reductase, putative 0.0048 0.0074 0.6688
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0018 0.1436
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0045 0.0066 0.0868
Plasmodium falciparum phd finger protein, putative 0.0029 0.0027 0.3474
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0217 0.0382
Echinococcus multilocularis chromobox protein 1 0.0075 0.0138 0.0138
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0039 0.0069
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0032 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0072 0.0131 0.0231
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.003 0.0029 0.036
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0032 0.0259
Echinococcus granulosus eukaryotic initiation factor 4A III 0.003 0.0029 0.005
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0029 0.0233
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0066 0.0559
Toxoplasma gondii thioredoxin reductase 0.0048 0.0074 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0072 0.0131 0.0231
Onchocerca volvulus Bile acid receptor homolog 0.0072 0.0131 0.0924
Toxoplasma gondii cytochrome p450 superfamily protein 0.0045 0.0066 0.0111
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0045 0.0066 0.0868
Brugia malayi PHD-finger family protein 0.0029 0.0027 0.0048
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0045 0.0066 0.0111
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0076 0.0141 0.0248
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0002 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0039 0.0069
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0056 0.0098
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0877 0.209 0.3668
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.003 0.0029 0.0512
Trichomonas vaginalis set domain proteins, putative 0.0491 0.1151 1
Plasmodium falciparum glutathione reductase 0.0048 0.0074 1
Brugia malayi hypothetical protein 0.0256 0.0578 0.1016
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.053 0.0931
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0194 0.0428 0.0752
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0367 0.3179
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0157
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0157
Trypanosoma brucei protein kinase, putative 0.031 0.0711 0.1245
Brugia malayi cytochrome P450 0.0045 0.0066 0.0116
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0045 0.0066 0.0868
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0001 0.0002
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0045 0.0066 0.0868
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.031 0.0711 0.1245
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0002 0.0003
Brugia malayi nuclear receptor NHR-88 0.0034 0.0039 0.0069
Brugia malayi jmjC domain containing protein 0.0041 0.0056 0.0098
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0045 0.0066 0.0868
Schistosoma mansoni glutaminase 0.0315 0.0723 0.1271
Trypanosoma brucei fructose-1,6-bisphosphatase 0.2358 0.5692 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0072 0.0131 0.0231
Loa Loa (eye worm) hypothetical protein 0.0072 0.0131 0.0231
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.01
Schistosoma mansoni retinoic acid receptor RXR 0.0072 0.0131 0.0231
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0032 0.0575
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0235 0.2025
Brugia malayi Heterochromatin protein 1 0.0075 0.0138 0.0243
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0045 0.0066 0.0868
Echinococcus multilocularis chromobox protein 1 0.0075 0.0138 0.0138
Echinococcus multilocularis epidermal growth factor receptor 0.1739 0.4188 0.4188
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0059 0.0277
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0039 0.0069
Loa Loa (eye worm) TK/EGFR protein kinase 0.1739 0.4188 0.7357
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0072 0.0131 0.0231
Brugia malayi Pre-SET motif family protein 0.0431 0.1006 0.1768
Schistosoma mansoni hypothetical protein 0.1047 0.2505 0.4401
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0194 0.0428 0.0752
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0072 0.0131 0.0924
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0039 0.0069
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0072 0.0131 0.0231
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0103 0.018
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0074 0.0131
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0045 0.0066 0.0868
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0194 0.0428 0.3707
Treponema pallidum ATP-dependent RNA helicase 0.003 0.0029 0.113
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0194 0.0428 0.3707
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0194 0.0428 0.0748
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0036 0.0063
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0235 0.0412
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0045 0.0066 0.0868
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0235 0.2025
Echinococcus granulosus ecdysone induced protein 78C 0.0072 0.0131 0.0231
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.031 0.0711 0.1245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0155 0.0272
Loa Loa (eye worm) hypothetical protein 0.0072 0.0131 0.0231
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.0271 0.0477
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0129 0.0227
Trichomonas vaginalis CMGC family protein kinase 0.031 0.0711 0.617
Schistosoma mansoni tyrosine kinase 0.0556 0.1309 0.2299
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0235 0.0408
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0582 0.5051
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0027 0.0027
Brugia malayi hypothetical protein 0.0236 0.053 0.0931
Loa Loa (eye worm) hypothetical protein 0.0256 0.0578 0.1016
Schistosoma mansoni hypothetical protein 0.1047 0.2505 0.4401
Brugia malayi fructose-1,6-bisphosphatase 0.2358 0.5692 1
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.0069
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0074 0.6688
Loa Loa (eye worm) TK/INSR protein kinase 0.0556 0.1309 0.2299
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0194 0.0428 0.0752
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0045 0.0066 0.0868
Brugia malayi Muscleblind-like protein 0.0154 0.0332 0.0583
Echinococcus multilocularis insulin receptor 0.0556 0.1309 0.1309
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0131 0.0231
Loa Loa (eye worm) hypothetical protein 0.0081 0.0155 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0072 0.0131 0.0231
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0225 0.3052
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0039 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0072 0.0131 0.0231
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0389 0.3371
Plasmodium vivax RNA helicase-1, putative 0.003 0.0029 0.2437
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.003 0.0029 0.0046
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0431 0.1006 0.1768
Echinococcus multilocularis 0.0045 0.0066 0.0066
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.031 0.0711 0.1245
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0039 0.0039
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0064 0.0112
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0225 0.8418
Schistosoma mansoni cytochrome P450 0.0045 0.0066 0.0116
Toxoplasma gondii fructose-bisphospatase II 0.2358 0.5692 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0029 0.0231
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.0202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0271 0.3687
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0045 0.0066 0.0111
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0138 0.1186
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0045 0.0066 0.0868
Schistosoma mansoni zinc finger protein 0.0028 0.0025 0.0043
Echinococcus granulosus epidermal growth factor receptor 0.0934 0.223 0.3918
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0072 0.0131 0.0231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0131 0.0131
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0194 0.0428 0.0748
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0039 0.0069
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.0224 0.0393
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0072 0.0131 0.0231
Loa Loa (eye worm) hypothetical protein 0.0072 0.0131 0.0231
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0141 0.0247
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.005
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0039 0.0039
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0367 0.3025
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0069
Toxoplasma gondii fructose-bisphospatase I 0.0877 0.209 0.3668
Brugia malayi Pre-SET motif family protein 0.0063 0.011 0.0194
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0072 0.0131 0.0131
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0032 0.0416
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2358 0.5692 1
Echinococcus granulosus chromobox protein 1 0.0075 0.0138 0.0243

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.8 uM Inhibitory activity of the compound evaluated in the HCV NS3 protease assay ChEMBL. 14611859

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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