Detailed information for compound 1213111

Basic information

Technical information
  • TDR Targets ID: 1213111
  • Name: N-(1,1-dioxothiolan-3-yl)-2-(4-ethylphenoxy)- N-methylacetamide
  • MW: 311.397 | Formula: C15H21NO4S
  • H donors: 0 H acceptors: 3 LogP: 1.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)OCC(=O)N(C1CCS(=O)(=O)C1)C
  • InChi: 1S/C15H21NO4S/c1-3-12-4-6-14(7-5-12)20-10-15(17)16(2)13-8-9-21(18,19)11-13/h4-7,13H,3,8-11H2,1-2H3
  • InChiKey: LKPOBHQMUOURDX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(1,1-dioxothiolan-3-yl)-2-(4-ethylphenoxy)-N-methyl-acetamide
  • N-(1,1-dioxo-3-thiolanyl)-2-(4-ethylphenoxy)-N-methylacetamide
  • N-(1,1-diketothiolan-3-yl)-2-(4-ethylphenoxy)-N-methyl-acetamide
  • N-(1,1-dioxothiolan-3-yl)-2-(4-ethylphenoxy)-N-methyl-ethanamide
  • Oprea1_270596
  • Enamine_000012
  • Oprea1_398069
  • BAS 00355368
  • MLS000097818
  • SMR000059921

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0319 0.0605 0.227
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.0022 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0221 0.0409 0.0408
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.0225 0.0841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.001 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0278 0.0523 0.1402
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0019 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0377 0.0723 0.0722
Schistosoma mansoni hypothetical protein 0.0404 0.0776 0.0775
Echinococcus granulosus methyl CpG binding domain protein 2 0.0073 0.0112 0.0111
Brugia malayi Cytochrome P450 family protein 0.0018 0.0001 0.0003
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0028 0.0023 0.0045
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.1343 0.2661 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.001 0.0027
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0319 0.0605 0.0604
Leishmania major hypothetical protein, conserved 0.0027 0.0019 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0219 0.082
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0294 0.0555 0.2068
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Mycobacterium tuberculosis Probable lipase LipE 0.0377 0.0723 0.1503
Trypanosoma cruzi hypothetical protein, conserved 0.0377 0.0723 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.001 0.0025
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.0088 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.001 0.0025
Echinococcus multilocularis musashi 0.0059 0.0084 0.0083
Trichomonas vaginalis glutaminase, putative 0.0266 0.05 0.1876
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0114 0.1562
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0698 0.1366 0.3657
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0055
Schistosoma mansoni ferritin 0.0028 0.0023 0.0022
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0085 0.0084
Echinococcus multilocularis sterol regulatory element binding protein 0.0126 0.0219 0.0218
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0006 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0006 0.0075
Loa Loa (eye worm) transcription factor SMAD2 0.0878 0.1726 0.4623
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0012 0.0011
Echinococcus granulosus expressed protein 0.0028 0.0023 0.0022
Leishmania major hypothetical protein, conserved 0.0377 0.0723 0.2714
Loa Loa (eye worm) MH2 domain-containing protein 0.0878 0.1726 0.4623
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0319 0.0605 0.0604
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0029 0.0075
Brugia malayi RNA recognition motif domain containing protein 0.053 0.103 0.2758
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0006 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.001 0.0027
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0018 0.0238
Plasmodium vivax macrophage migration inhibitory factor, putative 0.1343 0.2661 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0028 0.0102
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0018 0.0064
Loa Loa (eye worm) TAR-binding protein 0.053 0.103 0.2757
Echinococcus multilocularis protein patched 0.0126 0.0219 0.0218
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0066
Echinococcus granulosus geminin 0.1225 0.2424 0.2423
Brugia malayi Patched related family protein 12 0.0018 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0319 0.0605 0.1619
Plasmodium vivax importin-beta 2, putative 0.003 0.0026 0.0091
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0006 0.0017
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0049 0.0065 0.0241
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Brugia malayi Smad1 0.006 0.0086 0.0229
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0098 0.0203
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0114 0.0424
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0006 0.002
Brugia malayi cytochrome P450 0.0018 0.0001 0.0003
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3449 0.6886 0.6885
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0006 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0055
Loa Loa (eye worm) hypothetical protein 0.0126 0.0219 0.0583
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0018 0.0066
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0638 0.1246 0.3335
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0049 0.0065 0.0881
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.001 0.0027
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0006 0.0005
Brugia malayi hypothetical protein 0.0163 0.0292 0.0783
Loa Loa (eye worm) hypothetical protein 0.0154 0.0275 0.0736
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.001 0.0009
Echinococcus granulosus neuropeptide s receptor 0.0933 0.1837 0.1836
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0002 0.0007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0014 0.0052
Schistosoma mansoni smad1 5 8 and 0.006 0.0086 0.0085
Schistosoma mansoni patched 1 0.0126 0.0219 0.0218
Trichomonas vaginalis set domain proteins, putative 0.1015 0.2002 0.7525
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0126 0.0219 0.0583
Echinococcus multilocularis Niemann Pick C1 protein 0.0294 0.0555 0.0554
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.0776 0.0775
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0005 0.0004
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0114 0.0113
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0377 0.0723 0.1503
Toxoplasma gondii hypothetical protein 0.0319 0.0605 0.2272
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0319 0.0605 0.0604
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0005 0.0004
Onchocerca volvulus 0.0458 0.0884 0.2366
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0319 0.0605 0.1619
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0148 0.2036
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0114 0.1562
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.001 0.0027
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0006 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.0607 0.1623
Trichomonas vaginalis penicillin-binding protein, putative 0.0377 0.0723 0.2716
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0221 0.0409 0.1095
Mycobacterium tuberculosis Conserved protein 0.0377 0.0723 0.1503
Loa Loa (eye worm) hypothetical protein 0.0163 0.0292 0.0781
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0018 0.0046
Onchocerca volvulus 0.0377 0.0723 0.1935
Schistosoma mansoni cellular tumor antigen P53 0.0458 0.0884 0.0883
Plasmodium falciparum amino acid transporter, putative 0.0319 0.0605 0.227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0055
Echinococcus granulosus FTZ F1 alpha 0.0022 0.001 0.0009
Loa Loa (eye worm) macrophage migration inhibitory factor 0.1343 0.2661 0.7127
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0098 0.0163 0.0433
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0085 0.0175
Echinococcus granulosus snurportin 1 0.0319 0.0607 0.0606
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0042 0.0111
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0148 0.0553
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0025
Onchocerca volvulus Huntingtin homolog 0.0148 0.0262 0.0701
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0018 0.0238
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0052
Onchocerca volvulus 0.0098 0.0163 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.001 0.0027
Brugia malayi Heterochromatin protein 1 0.0068 0.0102 0.0274
Trichomonas vaginalis penicillin-binding protein, putative 0.0377 0.0723 0.2716
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Brugia malayi MAP kinase sur-1 0.0061 0.0088 0.0236
Brugia malayi Flap endonuclease-1 0.0026 0.0018 0.0048
Leishmania major importin beta-1 subunit, putative 0.0024 0.0014 0.005
Brugia malayi RNA, U transporter 1 0.0085 0.0136 0.0365
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0088 0.0087
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0084 0.0225
Echinococcus granulosus dna polymerase kappa 0.002 0.0006 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0377 0.0723 1
Onchocerca volvulus 0.0059 0.0084 0.0222
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.0019 0.0018
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.0019 0.0018
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0049 0.0065 0.0241
Schistosoma mansoni nuclear hormone receptor 0.0022 0.001 0.0009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0319 0.0605 0.1621
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0006 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0019 0.0251
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0049 0.0065 0.0064
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0014 0.0185
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.1343 0.2661 1
Schistosoma mansoni hypothetical protein 0.0319 0.0607 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0065 0.0241
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0028 0.0102
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0319 0.0605 0.0604
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0319 0.0605 0.1621
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0096 0.131
Loa Loa (eye worm) hypothetical protein 0.0319 0.0605 0.1619
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0019 0.0251
Echinococcus granulosus survival motor neuron protein 1 0.1275 0.2524 0.2523
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0006 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.0523 0.0523
Brugia malayi Pre-SET motif family protein 0.0129 0.0225 0.0602
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.0055
Schistosoma mansoni tar DNA-binding protein 0.053 0.103 0.1029
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0066
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0025
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0006 0.0014
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.001 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.0202 0.0371 0.037
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) glutaminase 2 0.0266 0.05 0.1336
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0048 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.0523 0.0523
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.014 0.0247 0.0246
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0148 0.0147
Brugia malayi protein C24B5.3 0.0018 0.0001 0.0004
Onchocerca volvulus Huntingtin homolog 0.0148 0.0262 0.0701
Onchocerca volvulus 0.1878 0.3733 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0006 0.0022
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0018 0.0236
Schistosoma mansoni lamin 0.0059 0.0084 0.0083
Brugia malayi nuclear receptor NHR-88 0.0022 0.001 0.0027
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0319 0.0605 0.0604
Mycobacterium ulcerans esterase/lipase LipP 0.0377 0.0723 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.001 0.0009
Schistosoma mansoni ferritin light chain 0.0028 0.0023 0.0022
Schistosoma mansoni tar DNA-binding protein 0.053 0.103 0.1029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0019 0.0067
Onchocerca volvulus 0.0098 0.0163 0.0433
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0213 0.0212
Echinococcus multilocularis tar DNA binding protein 0.053 0.103 0.1029
Trichomonas vaginalis D-aminoacylase, putative 0.0377 0.0723 0.2716
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0028 0.0023 0.0045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0278 0.0523 0.0523
Echinococcus multilocularis survival motor neuron protein 1 0.1275 0.2524 0.2523
Brugia malayi hypothetical protein 0.1275 0.2524 0.6761
Onchocerca volvulus 0.026 0.0487 0.1304
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis lamin 0.0059 0.0084 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.1343 0.2661 1
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0006 0.0075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1016 0.2005 0.537
Trichomonas vaginalis esterase, putative 0.0377 0.0723 0.2716
Mycobacterium tuberculosis Probable esterase LipL 0.0377 0.0723 0.1503
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0202 0.0371 0.037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0278 0.0523 0.14
Echinococcus granulosus intermediate filament protein 0.0059 0.0084 0.0083
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.0225 0.0224
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0042 0.011
Echinococcus granulosus fetal alzheimer antigen falz 0.01 0.0167 0.0166
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0006 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.001 0.0025
Mycobacterium ulcerans lipase LipD 0.0377 0.0723 1
Trichomonas vaginalis D-aminoacylase, putative 0.0377 0.0723 0.2716
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0006 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0088 0.0329
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0319 0.0605 0.0604
Brugia malayi protein C24B5.3 0.0018 0.0001 0.0004
Mycobacterium ulcerans glutaminase 0.0266 0.05 0.6906
Echinococcus multilocularis neuropeptide s receptor 0.0933 0.1837 0.1836
Loa Loa (eye worm) hypothetical protein 0.0377 0.0723 0.1934
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0023 0.0022
Echinococcus multilocularis Niemann Pick C1 protein 0.042 0.0808 0.0807
Loa Loa (eye worm) hypothetical protein 0.0148 0.0262 0.0701
Brugia malayi MH2 domain containing protein 0.0878 0.1726 0.4624
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0072
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0049
Schistosoma mansoni chromobox protein 0.0068 0.0102 0.0101
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0221 0.0829
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0018 0.0001 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0018 0.0238
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Mycobacterium ulcerans hypothetical protein 0.0377 0.0723 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.001 0.0009
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.0088 0.1207
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.001 0.0027
Schistosoma mansoni apoferritin-2 0.0028 0.0023 0.0022
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.001 0.0009
Plasmodium falciparum transporter, putative 0.0319 0.0605 0.227
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.001 0.0009
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0028 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0072
Leishmania major cytochrome p450-like protein 0.0026 0.0018 0.0064
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0148 0.2036
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0049 0.0065 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0202 0.0371 0.0993
Schistosoma mansoni hypothetical protein 0.0114 0.0195 0.0194
Loa Loa (eye worm) glutaminase 0.0266 0.05 0.1336
Onchocerca volvulus 0.0022 0.001 0.0025
Mycobacterium leprae conserved hypothetical protein 0.0377 0.0723 1
Onchocerca volvulus Protein patched homolog 0.0018 0.0001 0.0001
Echinococcus multilocularis zinc finger protein 0.0087 0.0141 0.014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0058
Entamoeba histolytica hypothetical protein 0.0114 0.0195 0.071
Brugia malayi RNA binding protein 0.053 0.103 0.2758
Schistosoma mansoni zinc finger protein 0.0066 0.0097 0.0096
Echinococcus multilocularis mothers against decapentaplegic 5 0.006 0.0086 0.0085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.001 0.0025
Brugia malayi Cytochrome P450 family protein 0.0026 0.0018 0.0048
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1223 0.2419 0.648
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0088 0.1207
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Trypanosoma brucei unspecified product 0.002 0.0006 0.0072
Schistosoma mansoni cpg binding protein 0.0071 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.001 0.0027
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0353 0.0674 0.1806
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0085 0.1166
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0000050139
Echinococcus granulosus lamin 0.0059 0.0084 0.0083
Toxoplasma gondii hypothetical protein 0.0031 0.0028 0.0103
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0032
Brugia malayi MH1 domain containing protein 0.006 0.0086 0.0229
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.001 0.0009
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0085 0.0084
Schistosoma mansoni ap endonuclease 0.002 0.0006 0.0005
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0019 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.001 0.0027
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.0088 0.0328
Brugia malayi nuclear hormone receptor 0.0022 0.001 0.0027
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0319 0.0605 0.0604
Onchocerca volvulus 0.0319 0.0605 0.1619
Leishmania major DNA polymerase kappa, putative 0.002 0.0006 0.002
Brugia malayi ecdysteroid receptor 0.0022 0.001 0.0027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.2412 0.4804 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0319 0.0605 0.1619
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0638 0.1246 0.3335
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0114 0.0426
Loa Loa (eye worm) hypothetical protein 0.0377 0.0723 0.1934
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.001 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.001 0.0025
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0114 0.1562
Trichomonas vaginalis ferritin, putative 0.0028 0.0023 0.0084
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.001 0.0009
Brugia malayi Patched protein homolog 1 0.0018 0.0001 0.0004
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0023 0.0011 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0084 0.0222
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.001 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0072
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.0088 0.1207
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0098 0.0163 0.0436
Schistosoma mansoni hypothetical protein 0.0089 0.0143 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni Smad4 0.0027 0.0019 0.0018
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0014 0.0052
Brugia malayi steroid hormone receptor 0.0022 0.001 0.0027
Schistosoma mansoni hypothetical protein 0.0122 0.0209 0.0209
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0319 0.0605 0.1621
Loa Loa (eye worm) hypothetical protein 0.0049 0.0065 0.017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni smad1 5 8 and 0.006 0.0086 0.0085
Entamoeba histolytica Ran family GTPase 0.0022 0.001 0.0014
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0049 0.0065 0.022
Brugia malayi glutaminase DH11.1 0.0266 0.05 0.1338
Echinococcus multilocularis beta LACTamase domain containing family member 0.0377 0.0723 0.0722
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0088 0.0329
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0006 0.0017
Onchocerca volvulus Protein patched homolog 0.0018 0.0001 0.0001
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0216 0.0215
Mycobacterium leprae Probable lipase LipE 0.0377 0.0723 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0006 0.0011
Plasmodium falciparum flap endonuclease 1 0.0026 0.0018 0.0063
Brugia malayi Niemann-Pick C1 protein precursor 0.0294 0.0555 0.1487
Echinococcus granulosus Niemann Pick C1 protein 0.042 0.0808 0.0807
Loa Loa (eye worm) hypothetical protein 0.0294 0.0555 0.1485
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Brugia malayi Cytochrome P450 family protein 0.0026 0.0018 0.0048
Echinococcus granulosus tar DNA binding protein 0.053 0.103 0.1029
Loa Loa (eye worm) hypothetical protein 0.0319 0.0605 0.1619
Brugia malayi intermediate filament protein 0.0059 0.0084 0.0225
Schistosoma mansoni microtubule-associated protein tau 0.5002 1 1
Schistosoma mansoni hypothetical protein 0.0122 0.0209 0.0209
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.001 0.0123
Echinococcus granulosus Protein patched homolog 1 0.0126 0.0219 0.0218
Plasmodium vivax amine transporter, putative 0.0319 0.0605 0.227
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0088 0.0329
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0018 0.0046
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0319 0.0605 0.2272
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0026 0.0342
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi TAR-binding protein 0.053 0.103 0.2758
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.001 0.0027
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0319 0.0605 0.1621
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0202 0.0371 0.0371
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0085 0.0175
Loa Loa (eye worm) hypothetical protein 0.0091 0.0148 0.0394
Onchocerca volvulus 0.0319 0.0605 0.1619
Toxoplasma gondii patched family protein 0.0018 0.0001 0.0002
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0098 0.0163 0.0436
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0049 0.0065 0.0881
Onchocerca volvulus 0.0098 0.0163 0.0433
Brugia malayi PHD-finger family protein 0.011 0.0187 0.0501
Brugia malayi Bromodomain containing protein 0.0164 0.0295 0.0791
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0086 0.0227
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.001 0.0009
Echinococcus granulosus zinc finger protein 0.0087 0.0141 0.014
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0148 1
Schistosoma mansoni ferritin 0.0028 0.0023 0.0022
Schistosoma mansoni sodium/chloride dependent transporter 0.0319 0.0606 0.0605
Loa Loa (eye worm) solute carrier family 6 member 4 0.1878 0.3733 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0319 0.0605 0.0604
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0052
Echinococcus granulosus beta LACTamase domain containing family member 0.0377 0.0723 0.0722
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Brugia malayi Probable ClpP-like protease 0.0091 0.0148 0.0396
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0028 0.0381
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0006 0.0005
Toxoplasma gondii hypothetical protein 0.0319 0.0605 0.2272
Trypanosoma brucei ISWI complex protein 0.0066 0.0097 0.1335
Loa Loa (eye worm) serotonin transporter b 0.1878 0.3733 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0055
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0019 0.0049
Loa Loa (eye worm) hypothetical protein 0.0221 0.0409 0.1092
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Schistosoma mansoni TGF-beta signal transducer Smad2 0.006 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0025
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0049 0.0065 0.0064
Echinococcus granulosus sodium and chloride dependent glycine 0.0319 0.0605 0.0604
Schistosoma mansoni methyl-cpg binding protein mbd 0.0073 0.0112 0.0112
Brugia malayi hypothetical protein 0.0114 0.0195 0.0521
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0319 0.0605 1
Mycobacterium tuberculosis Probable lipase LipD 0.0377 0.0723 0.1503
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0114 0.0405
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0319 0.0605 0.2272
Onchocerca volvulus 0.0377 0.0723 0.1935
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0028 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Echinococcus granulosus serotonin transporter 0.1878 0.3733 0.3733
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Leishmania major GTP-binding protein, putative 0.0022 0.001 0.0033
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0148 0.0551
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0018 0.0045
Brugia malayi MH1 domain containing protein 0.006 0.0086 0.0229
Trichomonas vaginalis D-aminoacylase, putative 0.0377 0.0723 0.2716
Echinococcus multilocularis smad 0.006 0.0086 0.0085
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0114 0.0113
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0018 0.0064
Schistosoma mansoni cytochrome P450 0.0018 0.0001 0.0000050139
Schistosoma mansoni sodium/chloride dependent transporter 0.1878 0.3733 0.3733
Brugia malayi Latrophilin receptor protein 2 0.0221 0.0409 0.1095
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.001 0.0009
Schistosoma mansoni methyl-cpg binding protein mbd 0.0073 0.0112 0.0112
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0278 0.0523 0.0523
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0072
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.0088 0.0087
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0019 0.0067
Brugia malayi beta-lactamase 0.0377 0.0723 0.1937
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0018 0.0238
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0018 0.0063
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0319 0.0605 0.0604
Leishmania major macrophage migration inhibitory factor-like protein 0.1343 0.2661 1
Brugia malayi Patched related family protein 10 0.0018 0.0001 0.0004
Echinococcus multilocularis sodium and chloride dependent glycine 0.0319 0.0605 0.0604
Schistosoma mansoni inositol monophosphatase 0.0074 0.0114 0.0113
Plasmodium vivax SET domain protein, putative 0.0129 0.0225 0.0839
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis Smad4 0.006 0.0086 0.0085
Echinococcus multilocularis expressed protein 0.0028 0.0023 0.0022
Onchocerca volvulus 0.0098 0.0163 0.0433
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni survival motor neuron protein 0.026 0.0487 0.0487
Loa Loa (eye worm) nuclear factor I 0.0033 0.0032 0.0083
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.0055
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1878 0.3733 0.3733
Treponema pallidum bacterioferrin (TpF1) 0.0028 0.0023 0.0044
Echinococcus multilocularis chromobox protein 1 0.0068 0.0102 0.0101
Brugia malayi MH2 domain containing protein 0.006 0.0086 0.0229
Schistosoma mansoni bromodomain containing protein 0.0022 0.0009 0.0008
Schistosoma mansoni ran 0.0022 0.001 0.0009
Echinococcus multilocularis geminin 0.1225 0.2424 0.2423
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0086 0.0227
Schistosoma mansoni bromodomain containing protein 0.0275 0.0517 0.0516
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0098 0.0163 0.0433
Echinococcus multilocularis microtubule associated protein 2 0.5002 1 1
Schistosoma mansoni ran 0.0022 0.001 0.0009
Brugia malayi N-terminal motif family protein 0.0199 0.0366 0.098
Echinococcus granulosus ferritin 0.0028 0.0023 0.0022
Mycobacterium tuberculosis Conserved protein 0.0377 0.0723 0.1503
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.001 0.0009
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0098 0.1347
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.001 0.0009
Echinococcus multilocularis dna polymerase eta 0.002 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0098 0.0163 0.0433
Echinococcus granulosus mothers against decapentaplegic 5 0.006 0.0086 0.0085
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0028 0.0023 0.0302
Brugia malayi CHE-14 protein 0.0126 0.0219 0.0586
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0055
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 0.0366 0.0977
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Echinococcus multilocularis protein dispatched 1 0.0144 0.0254 0.0253
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0005 0.0004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0006 0.0075
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0026
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0319 0.0605 0.1619
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0049 0.0065 0.022
Schistosoma mansoni zinc finger protein 0.0087 0.0141 0.014
Brugia malayi secreted modular calcium-binding protein 1 0.0098 0.0163 0.0436
Brugia malayi CHD4 protein 0.0023 0.0011 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0019 0.0049
Schistosoma mansoni glutaminase 0.0266 0.05 0.0499
Loa Loa (eye worm) hypothetical protein 0.0165 0.0296 0.079
Loa Loa (eye worm) hypothetical protein 0.0319 0.0605 0.1619
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0012 0.0011
Brugia malayi CXXC zinc finger family protein 0.0059 0.0085 0.0227
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0319 0.0605 0.0604
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.0088 0.1207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0278 0.0523 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.001 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0048 0.0178
Loa Loa (eye worm) CHromoDomain protein family member 0.0023 0.0011 0.0027
Trypanosoma brucei protein kinase, putative 0.0061 0.0088 0.1207
Schistosoma mansoni thyroid hormone receptor 0.0147 0.026 0.026
Schistosoma mansoni smad1 5 8 and 0.006 0.0086 0.0085
Echinococcus multilocularis serotonin transporter 0.1878 0.3733 0.3733
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.001 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0377 0.0723 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0084 0.0222
Onchocerca volvulus 0.0018 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0377 0.0723 0.1503
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.026 0.0259
Brugia malayi hypothetical protein 0.0319 0.0605 0.1621
Echinococcus multilocularis importin subunit beta 1 0.003 0.0026 0.0025
Brugia malayi MH2 domain containing protein 0.006 0.0086 0.0229
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.1343 0.2661 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.001 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.001 0.0027
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0042 0.0157
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.001 0.0123
Echinococcus granulosus chromobox protein 1 0.0068 0.0102 0.0101
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0005 0.0004
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0072 0.0191
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0377 0.0723 0.1937
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0539 0.1047 0.1047
Echinococcus multilocularis ferritin 0.0028 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0122 0.0209 0.0209
Echinococcus granulosus Smad4 0.006 0.0086 0.0085
Echinococcus granulosus tumor protein p63 0.3127 0.6239 0.6239
Echinococcus granulosus sodium and chloride dependent glycine 0.0319 0.0605 0.0604
Brugia malayi mothers against decapentaplegic homolog 3 0.0027 0.0019 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0018 0.0046
Loa Loa (eye worm) hypothetical protein 0.0377 0.0723 0.1934
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0006 0.0072
Brugia malayi Bm-MIF-1, identical 0.1343 0.2661 0.7128
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0096 0.0095
Schistosoma mansoni cpg binding protein 0.0059 0.0085 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis TGF beta signal transducer SmadC 0.006 0.0086 0.0085
Onchocerca volvulus 0.0319 0.0605 0.1619
Onchocerca volvulus 0.1015 0.2002 0.5362
Loa Loa (eye worm) hypothetical protein 0.0098 0.0163 0.0433
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0072
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.026 0.0486 0.0485
Echinococcus multilocularis neuropeptide receptor A26 0.0933 0.1837 0.1836
Onchocerca volvulus 0.0018 0.0001 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0539 0.1047 0.1047
Plasmodium vivax hypothetical protein, conserved 0.0377 0.0723 0.2713
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0148 0.0553
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0018 0.0046
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0018 0.0236
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0072
Onchocerca volvulus 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0319 0.0605 0.1619
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0006 0.0072
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0049 0.0065 0.0064
Onchocerca volvulus 0.0018 0.0001 0.0001
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0023 0.0011 0.001
Schistosoma mansoni Smad4 0.006 0.0086 0.0085
Schistosoma mansoni tar DNA-binding protein 0.053 0.103 0.1029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.001 0.0027
Brugia malayi hypothetical protein 0.0018 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0221 0.0409 0.0408
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0102 0.0382
Brugia malayi SET domain containing protein 0.0018 0.0001 0.0002
Schistosoma mansoni inositol monophosphatase 0.0074 0.0114 0.0113
Echinococcus multilocularis lamin dm0 0.0059 0.0084 0.0083
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.001 0.0025
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0216 0.0215
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0049 0.0065 0.0173
Entamoeba histolytica hypothetical protein 0.0114 0.0195 0.071
Schistosoma mansoni flap endonuclease-1 0.0024 0.0013 0.0012
Schistosoma mansoni hypothetical protein 0.0221 0.0409 0.0408
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0154 0.0275 0.0274
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0014 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.002 0.0073
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0023 0.0022
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0298 0.0564 0.0563
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0195 0.0194
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0114 0.0426
Brugia malayi chromobox protein homolog 3 0.0038 0.0042 0.0113
Schistosoma mansoni apoferritin-2 0.0028 0.0023 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.1275 0.2524 0.676
Schistosoma mansoni chromobox protein 0.0068 0.0102 0.0101
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.1878 0.3733 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0006 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.001 0.0027
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0006 0.0011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0377 0.0723 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.0366 0.0977
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Toxoplasma gondii ABC1 family protein 0.0377 0.0723 0.2714
Echinococcus granulosus lamin dm0 0.0059 0.0084 0.0083
Echinococcus granulosus chromobox protein 1 0.0068 0.0102 0.0101
Brugia malayi hypothetical protein 0.0027 0.0019 0.0051
Brugia malayi Inositol-1 0.0074 0.0114 0.0305
Schistosoma mansoni ferritin light chain 0.0028 0.0023 0.0022
Echinococcus granulosus cpg binding protein 0.0071 0.0108 0.0107
Leishmania major DNA polymerase eta, putative 0.002 0.0006 0.002
Echinococcus multilocularis GPCR, family 2 0.0221 0.0409 0.0408
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0319 0.0605 0.2272
Echinococcus multilocularis dna polymerase kappa 0.002 0.0006 0.0005
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0025
Onchocerca volvulus 0.0059 0.0085 0.0225
Echinococcus granulosus Niemann Pick C1 protein 0.0294 0.0555 0.0554
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.001 0.0009
Brugia malayi Myosin head containing protein 0.0018 0.0001 0.0004
Echinococcus multilocularis cpg binding protein 0.0071 0.0108 0.0107
Brugia malayi hypothetical protein 0.0018 0.0001 0.0004
Brugia malayi beta-lactamase family protein 0.0377 0.0723 0.1937
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.001 0.0025
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.0088 0.0234
Schistosoma mansoni intermediate filament proteins 0.0059 0.0084 0.0083
Brugia malayi Patched related family protein 4 0.0018 0.0001 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.0523 0.0523
Brugia malayi Importin beta-1 subunit 0.003 0.0026 0.0069
Brugia malayi MH1 domain containing protein 0.0033 0.0032 0.0086
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0096 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0114 0.1562
Loa Loa (eye worm) hypothetical protein 0.1878 0.3733 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.0316 0.0845
Echinococcus multilocularis expressed conserved protein 0.0276 0.0519 0.0518
Loa Loa (eye worm) hypothetical protein 0.0098 0.0163 0.0433
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0377 0.0723 0.0722
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0377 0.0723 0.1934
Brugia malayi hypothetical protein 0.0148 0.0262 0.0703
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.001 0.0009
Schistosoma mansoni smad 0.006 0.0086 0.0085
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0319 0.0605 0.0604
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0078 0.0205
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0114 0.0426
Schistosoma mansoni hypothetical protein 0.0066 0.0097 0.0096
Schistosoma mansoni hypothetical protein 0.1225 0.2424 0.2423
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0096 0.0256
Toxoplasma gondii patched family protein 0.0018 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0377 0.0723 0.1934
Loa Loa (eye worm) latrophilin receptor protein 2 0.0221 0.0409 0.1092
Mycobacterium tuberculosis Conserved protein 0.0377 0.0723 0.1503
Mycobacterium ulcerans bacterioferritin BfrA 0.0028 0.0023 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Onchocerca volvulus 0.0377 0.0723 0.1935
Brugia malayi follicle stimulating hormone receptor 0.1223 0.2419 0.6481
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0221 0.0409 0.0408
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0319 0.0605 0.0604
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0019 0.0068
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.0019 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0202 0.0371 0.0371
Loa Loa (eye worm) Smad1 0.006 0.0086 0.0227
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0006 0.0014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.053 0.103 0.2757
Schistosoma mansoni smad 0.0027 0.0019 0.0018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0148 0.0551
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0096 0.0095
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0028 0.0023 0.1158
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0029 0.0078
Schistosoma mansoni tar DNA-binding protein 0.053 0.103 0.1029
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.001 0.0009
Echinococcus granulosus sterol regulatory element binding protein 0.0126 0.0219 0.0218
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0154 0.0275 0.0274
Loa Loa (eye worm) hypothetical protein 0.0186 0.034 0.0907
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0049 0.0065 0.0064
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.001 0.0033
Schistosoma mansoni sodium/chloride dependent transporter 0.0319 0.0605 0.0604
Trichomonas vaginalis ran, putative 0.0022 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.026 0.0486 0.0485
Mycobacterium tuberculosis Probable hydrolase 0.0377 0.0723 0.1503
Toxoplasma gondii hypothetical protein 0.0018 0.0001 0.0002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.0096 0.0197
Echinococcus multilocularis fetal alzheimer antigen, falz 0.01 0.0167 0.0166
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0319 0.0605 0.0604
Entamoeba histolytica hypothetical protein 0.0114 0.0195 0.071
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0698 0.1366 0.3659
Echinococcus granulosus dnaJ subfamily B 0.0404 0.0776 0.0775
Toxoplasma gondii patched family protein 0.0018 0.0001 0.0002
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Brugia malayi hypothetical protein 0.0018 0.0001 0.0004
Echinococcus multilocularis tumor protein p63 0.3127 0.6239 0.6239
Trypanosoma cruzi ISWI complex protein 0.0066 0.0097 0.1335
Echinococcus granulosus flap endonuclease 1 0.0026 0.0018 0.0017
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0458 0.0884 0.2366
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0377 0.0723 0.1503
Loa Loa (eye worm) RNA binding protein 0.053 0.103 0.2757
Loa Loa (eye worm) hypothetical protein 0.0377 0.0723 0.1934
Loa Loa (eye worm) hypothetical protein 0.0148 0.0262 0.0701
Echinococcus granulosus importin subunit beta 1 0.003 0.0026 0.0025
Entamoeba histolytica hypothetical protein 0.0024 0.0014 0.0031
Echinococcus granulosus ubiquitin specific protease 41 0.0049 0.0065 0.0064
Schistosoma mansoni hypothetical protein 0.0125 0.0216 0.0215
Schistosoma mansoni hypothetical protein 0.0221 0.0409 0.0408
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0102 0.0271
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.01 0.0167 0.0166
Brugia malayi latrophilin 2 splice variant baaae 0.0477 0.0923 0.2472
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0006 0.0075
Schistosoma mansoni hypothetical protein 0.0122 0.0209 0.0209
Entamoeba histolytica hypothetical protein 0.0114 0.0195 0.071
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0148 0.0147
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.001 0.0009
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.0096 0.0356
Mycobacterium ulcerans beta-lactamase 0.0377 0.0723 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0072
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0148 0.2036
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0319 0.0605 0.0604
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0025
Schistosoma mansoni importin beta-1 0.003 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0006 0.0072
Loa Loa (eye worm) hypothetical protein 0.0319 0.0605 0.1619
Onchocerca volvulus 0.003 0.0026 0.0066
Treponema pallidum sodium- and chloride- dependent transporter 0.1878 0.3733 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.001 0.0027
Echinococcus multilocularis snurportin 1 0.0319 0.0607 0.0606
Schistosoma mansoni cpg binding protein 0.0071 0.0108 0.0107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0221 0.0409 0.0408
Schistosoma mansoni ap endonuclease 0.002 0.0006 0.0005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0319 0.0605 0.0604
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0088 0.0329
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0048 0.0126
Schistosoma mansoni ferritin 0.0028 0.0023 0.0022
Echinococcus granulosus expressed conserved protein 0.0276 0.0519 0.0518
Leishmania major macrophage migration inhibitory factor-like protein 0.1343 0.2661 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0319 0.0605 0.0604
Leishmania major hypothetical protein, conserved 0.0066 0.0097 0.0362
Toxoplasma gondii patched family protein 0.0018 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.1016 0.2005 0.5369
Plasmodium falciparum macrophage migration inhibitory factor 0.1343 0.2661 1
Loa Loa (eye worm) beta-lactamase 0.0377 0.0723 0.1934
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0006 0.0021
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0477 0.0923 0.0922
Echinococcus granulosus dna polymerase eta 0.002 0.0006 0.0005
Schistosoma mansoni DNA polymerase eta 0.002 0.0006 0.0005
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0027 0.0019 0.0049
Onchocerca volvulus 0.0059 0.0084 0.0222
Schistosoma mansoni hypothetical protein 0.026 0.0487 0.0487
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0148 0.0147
Brugia malayi MH1 domain containing protein 0.0033 0.0032 0.0086
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0022
Echinococcus granulosus GPCR family 2 0.0221 0.0409 0.0408
Brugia malayi hypothetical protein 0.0018 0.0001 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.001 0.0027
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0073 0.0112 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0278 0.0523 0.0523
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0195 0.0194
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.0088 0.0328
Schistosoma mansoni Smad4 0.0027 0.0019 0.0018
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.0088 0.0087
Echinococcus multilocularis chromobox protein 1 0.0068 0.0102 0.0101
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0114 0.0424
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1878 0.3733 1
Brugia malayi Cytochrome P450 family protein 0.0056 0.0078 0.0208
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0319 0.0605 0.0604
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0195 0.0194
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.001 0.0009
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.0088 0.0328
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0026 0.0093
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0006 0.0072
Loa Loa (eye worm) hypothetical protein 0.0098 0.0163 0.0433
Toxoplasma gondii exonuclease III APE 0.002 0.0006 0.002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0049 0.0065 0.0881
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0353 0.0674 0.1804
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0084 0.0222
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0006 0.0005
Onchocerca volvulus 0.0018 0.0001 0.0001
Onchocerca volvulus 0.014 0.0247 0.0659
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0892 0.1755 0.4701
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0011 0.001
Echinococcus granulosus smad 0.006 0.0086 0.0085
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.001 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0042 0.0157
Trypanosoma cruzi ISWI complex protein 0.0066 0.0097 0.1335
Loa Loa (eye worm) bromodomain containing protein 0.0076 0.0118 0.0313
Loa Loa (eye worm) norepinephrine transporter 0.1878 0.3733 1
Schistosoma mansoni tar DNA-binding protein 0.053 0.103 0.1029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0055
Brugia malayi Bromodomain containing protein 0.0325 0.0618 0.1656
Loa Loa (eye worm) hypothetical protein 0.0377 0.0723 0.1934
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0049 0.0065 0.0064
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0344 0.0655 0.246
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0025
Brugia malayi Pre-SET motif family protein 0.0892 0.1755 0.4702
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0143 0.0381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0049
Brugia malayi MH2 domain containing protein 0.0027 0.0019 0.0052
Schistosoma mansoni hypothetical protein 0.1225 0.2424 0.2423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.001 0.0025
Echinococcus granulosus neuropeptide receptor A26 0.0933 0.1837 0.1836
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0088 0.1207
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0083
Onchocerca volvulus 0.0163 0.0292 0.0781
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0148 0.038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0018 0.0001 0.0001
Mycobacterium ulcerans bacterioferritin BfrB 0.0028 0.0023 0.0302
Loa Loa (eye worm) hypothetical protein 0.0477 0.0923 0.247
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.001 0.0027
Brugia malayi beta-lactamase family protein 0.0377 0.0723 0.1937
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0114 0.7584
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0049 0.0065 0.0064
Brugia malayi Patched family protein 0.0018 0.0001 0.0004
Echinococcus multilocularis ubiquitin specific protease 41 0.0049 0.0065 0.0064
Plasmodium falciparum importin beta, putative 0.003 0.0026 0.0091
Loa Loa (eye worm) hypothetical protein 0.1878 0.3733 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0147 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0058 0.0082 0.0216
Schistosoma mansoni lamin 0.0059 0.0084 0.0083
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0098 0.0163 0.0436
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0096 0.0095
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0085 0.0225
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0026 0.0342
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.026 0.0487 0.1306
Loa Loa (eye worm) inositol-1 0.0074 0.0114 0.0302
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0102 0.0382
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0006 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0006 0.0017
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0018 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0228 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0225 0.0224
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0303 0.0574 0.1537
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.001 0.0123
Giardia lamblia Macrophage migration inhibitory factor 0.1343 0.2661 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.001 0.0009
Echinococcus granulosus TGF beta signal transducer SmadC 0.006 0.0086 0.0085
Schistosoma mansoni ferritin 0.0028 0.0023 0.0022

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.2995 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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