Detailed information for compound 1227601

Basic information

Technical information
  • TDR Targets ID: 1227601
  • Name: [2-oxo-4-(trifluoromethyl)chromen-7-yl] 2-[(4 -methylphenyl)sulfonylamino]-2-phenylacetate
  • MW: 517.474 | Formula: C25H18F3NO6S
  • H donors: 1 H acceptors: 4 LogP: 4.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(cc1)S(=O)(=O)NC(c1ccccc1)C(=O)Oc1ccc2c(c1)oc(=O)cc2C(F)(F)F
  • InChi: 1S/C25H18F3NO6S/c1-15-7-10-18(11-8-15)36(32,33)29-23(16-5-3-2-4-6-16)24(31)34-17-9-12-19-20(25(26,27)28)14-22(30)35-21(19)13-17/h2-14,23,29H,1H3
  • InChiKey: NNLCQIISQBEMGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-oxo-4-(trifluoromethyl)chromen-7-yl] 2-[(4-methylphenyl)sulfonylamino]-2-phenyl-acetate
  • 2-[(4-methylphenyl)sulfonylamino]-2-phenylacetic acid [2-oxo-4-(trifluoromethyl)-7-chromenyl] ester
  • 2-[(4-methylphenyl)sulfonylamino]-2-phenyl-acetic acid [2-keto-4-(trifluoromethyl)chromen-7-yl] ester
  • [2-oxo-4-(trifluoromethyl)chromen-7-yl] 2-[(4-methylphenyl)sulfonylamino]-2-phenyl-ethanoate
  • MLS000588644
  • Phenyl-(toluene-4-sulfonylamino)-acetic acid 2-oxo-4-trifluoromethyl-2H-chromen-7-yl ester
  • SMR000212243
  • STOCK1S-32726

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0093 0.0772
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Plasmodium falciparum DNA gyrase subunit A 0.0288 0.3244 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0154 0.0475
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0033 0.0101
Echinococcus multilocularis muscleblind protein 0.018 0.2008 0.2008
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0069 0.0569
Loa Loa (eye worm) hypothetical protein 0.0019 0.0166 0.0379
Loa Loa (eye worm) patched family protein 0.0006 0.0021 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0033 0.0101
Schistosoma mansoni rotamase 0.004 0.0408 0.0729
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0033 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0241 0.0548
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0093 0.0772
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013 0.0093 0.0287
Brugia malayi hypothetical protein 0.0006 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.018 0.2008 0.458
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0113
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.0093 0.0772
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0456 0.1407
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0093 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0069 0.0213
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0393 0.0702
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0059 0.0105
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0093 0.0287
Echinococcus granulosus expressed protein 0.001 0.0064 0.0114
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0062 0.066 0.2045
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0033 0.0059
Schistosoma mansoni ferritin 0.001 0.0064 0.0114
Loa Loa (eye worm) hypothetical protein 0.0026 0.0241 0.0548
Schistosoma mansoni ferritin 0.001 0.0064 0.0114
Schistosoma mansoni hypothetical protein 0.0494 0.5592 1
Loa Loa (eye worm) patched family protein 0.0006 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Trypanosoma brucei DNA topoisomerase ii 0.011 0.1205 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.001 0.006 0.0497
Plasmodium vivax DNA gyrase subunit B, putative 0.0139 0.1532 0.469
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0093 0.0212
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0166 0.0512
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0087 0.072
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0241 0.1584
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0033 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0093 0.0287
Schistosoma mansoni hypothetical protein 0.0044 0.0451 0.0807
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0069 0.0213
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0139 0.1532 0.4724
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0456 0.1407
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.006 0.006
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0397 0.3291
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0048 0.0493 0.3244
Loa Loa (eye worm) hypothetical protein 0.0056 0.0588 0.1342
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3224 1
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0288 0.3244 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0033 0.0101
Schistosoma mansoni cpg binding protein 0.0035 0.0343 0.0613
Loa Loa (eye worm) TOPoisomerase family member 0.0062 0.066 0.1504
Toxoplasma gondii patched family protein 0.0006 0.0021 0.0063
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0062 0.066 0.2045
Chlamydia trachomatis DNA gyrase subunit B 0.0139 0.1532 0.4724
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0802 0.1435
Loa Loa (eye worm) hypothetical protein 0.0019 0.0166 0.0379
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013 0.0093 0.0287
Onchocerca volvulus 0.0037 0.0367 0.1139
Brugia malayi topoisomerase 0.0011 0.0069 0.0157
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.001 0.006 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0113
Brugia malayi CXXC zinc finger family protein 0.0035 0.0343 0.0782
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013 0.0093 0.0287
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0456 0.1415
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Chlamydia trachomatis DNA gyrase subunit A 0.003 0.0289 0.0891
Schistosoma mansoni hypothetical protein 0.0044 0.0451 0.0807
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Schistosoma mansoni inositol monophosphatase 0.0045 0.0456 0.0816
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.0087 0.0084
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0069 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0157
Trypanosoma cruzi DNA topoisomerase IA, putative 0.001 0.006 0.0497
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2828 0.6448
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0456 0.0816
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0093 0.0287
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0033 0.0282
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0288 0.3244 1
Onchocerca volvulus 0.0008 0.0033 0.0102
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0033 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0093 0.0287
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.011 0.1205 1
Brugia malayi MH1 domain containing protein 0.001 0.0059 0.0134
Plasmodium falciparum DNA topoisomerase 3, putative 0.001 0.006 0.0122
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.0087 0.072
Brugia malayi protein C24B5.3 0.0006 0.0021 0.0047
Trypanosoma brucei DNA topoisomerase III, putative 0.001 0.006 0.0497
Loa Loa (eye worm) hypothetical protein 0.003 0.0289 0.0659
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0154 0.0475
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013 0.0093 0.0287
Plasmodium vivax DNA gyrase subunit A, putative 0.0288 0.3244 1
Echinococcus multilocularis 0.0013 0.0093 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0093 0.0287
Plasmodium vivax DNA topoisomerase II, putative 0.0062 0.066 0.1982
Brugia malayi MH2 domain containing protein 0.001 0.0059 0.0134
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0113
Loa Loa (eye worm) hypothetical protein 0.0107 0.1167 0.2662
Trypanosoma cruzi DNA topoisomerase III, putative 0.001 0.006 0.0497
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5592 0.5592
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.006 0.0108
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0064 0.0196
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0021 0.0064
Loa Loa (eye worm) patched family protein 0.0006 0.0021 0.0047
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0713 0.2197
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.001 0.006 0.0107
Echinococcus multilocularis protein dispatched 1 0.0052 0.0544 0.0544
Trypanosoma cruzi DNA topoisomerase II, putative 0.0052 0.0546 0.4531
Brugia malayi Inositol-1 0.0045 0.0456 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0408 0.1264
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0033 0.0102
Loa Loa (eye worm) hypothetical protein 0.0019 0.0166 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0113
Echinococcus multilocularis expressed protein 0.001 0.0064 0.0064
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.1691 0.3024
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0138 0.1518 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0069 0.0212
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.001 0.006 0.0185
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Echinococcus granulosus ferritin 0.001 0.0064 0.0114
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0064 0.0196
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0157
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0093 0.0772
Brugia malayi Cytochrome P450 family protein 0.0013 0.0093 0.0212
Toxoplasma gondii DNA topoisomerase family protein 0.001 0.006 0.0185
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0033 0.0075
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Brugia malayi Patched related family protein 4 0.0006 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Onchocerca volvulus Protein patched homolog 0.0006 0.0021 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0241 0.2061
Brugia malayi Patched related family protein 10 0.0006 0.0021 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0154 0.0475
Brugia malayi protein C24B5.3 0.0006 0.0021 0.0047
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0093 0.0287
Treponema pallidum DNA ligase (lig) 0.0011 0.0069 0.0027
Schistosoma mansoni smad1 5 8 and 0.001 0.0059 0.0105
Toxoplasma gondii patched family protein 0.0006 0.0021 0.0063
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0033 0.0101
Brugia malayi hypothetical protein 0.0006 0.0021 0.0047
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0069 0.0213
Echinococcus multilocularis protein patched 0.0046 0.047 0.047
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0084 0.0084
Echinococcus granulosus Smad4 0.001 0.0059 0.0105
Trypanosoma brucei DNA topoisomerase IA, putative 0.001 0.006 0.0497
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0033 0.0101
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0077 0.0826 0.2546
Toxoplasma gondii hypothetical protein 0.0006 0.0021 0.0063
Echinococcus multilocularis muscleblind protein 1 0.018 0.2008 0.2008
Echinococcus granulosus protein quaking 0.0033 0.0322 0.0576
Brugia malayi Probable DNA topoisomerase II 0.0062 0.066 0.1504
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0033 0.0101
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0456 0.1415
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0093 0.0287
Echinococcus granulosus geminin 0.0205 0.2285 0.4087
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.001 0.006 0.0186
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1594 0.3636
Giardia lamblia DNA topoisomerase III 0.001 0.006 0.0983
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0075
Loa Loa (eye worm) nuclear factor I 0.0005 0.0009 0.002
Brugia malayi MH2 domain containing protein 0.001 0.0059 0.0134
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.008 0.0863 0.2661
Leishmania major DNA topoisomerase 1A 0.001 0.006 0.0497
Onchocerca volvulus 0.0011 0.0069 0.0213
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0456 0.3785
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0403 0.2654
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0033 0.0101
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013 0.0093 0.0287
Echinococcus granulosus tumor protein p63 0.0408 0.461 0.8244
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0033 0.0273
Loa Loa (eye worm) tumor suppressor 0.0388 0.4385 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013 0.0093 0.0287
Brugia malayi MH1 domain containing protein 0.0005 0.0009 0.002
Schistosoma mansoni hypothetical protein 0.0039 0.0393 0.0702
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0069 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0113
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0241 0.1995
Echinococcus multilocularis cpg binding protein 0.0037 0.0366 0.0366
Trypanosoma cruzi DNA topoisomerase III, putative 0.001 0.006 0.0497
Loa Loa (eye worm) hypothetical protein 0.0019 0.0166 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0113
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0059 0.0059
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0052 0.0546 0.4531
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.1167 0.1167
Trypanosoma cruzi DNA topoisomerase IA, putative 0.001 0.006 0.0497
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0093 0.0287
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.016 0.1778 0.5482
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0033 0.0273
Giardia lamblia DNA topoisomerase III 0.001 0.006 0.0983
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0093 0.0167
Leishmania major cytochrome p450-like protein 0.0013 0.0093 0.0772
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0062 0.066 0.2045
Loa Loa (eye worm) hypothetical protein 0.018 0.2008 0.458
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0367 0.0837
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0033 0.0101
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0059 0.0105
Onchocerca volvulus 0.0287 0.3224 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0166 0.0512
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0033 0.0273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0033 0.0101
Brugia malayi hypothetical protein 0.0006 0.0021 0.0047
Onchocerca volvulus 0.0006 0.0021 0.0064
Chlamydia trachomatis DNA ligase 0.0011 0.0069 0.0212
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0456 0.3785
Brugia malayi hypothetical protein 0.0011 0.0069 0.0157
Echinococcus multilocularis expressed protein 0.004 0.0408 0.0408
Onchocerca volvulus 0.006 0.0629 0.1951
Brugia malayi hypothetical protein 0.0033 0.0322 0.0735
Brugia malayi cytochrome P450 0.0013 0.0093 0.0212
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0456 0.1415
Brugia malayi hypothetical protein 0.0006 0.0021 0.0047
Schistosoma mansoni cpg binding protein 0.0037 0.0366 0.0654
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0241 0.1995
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0241 0.0741
Onchocerca volvulus 0.0012 0.0086 0.0267
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013 0.0093 0.0287
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013 0.0093 0.0287
Mycobacterium ulcerans DNA gyrase subunit B 0.0139 0.1532 0.4724
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.062 0.1413
Schistosoma mansoni hypothetical protein 0.0044 0.0451 0.0807
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0069 0.0027
Loa Loa (eye worm) Smad1 0.001 0.0059 0.0134
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0241 0.0548
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0093 0.0287
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0456 0.3785
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0087 0.072
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0393 0.0393
Giardia lamblia DNA topoisomerase II 0.0058 0.061 1
Echinococcus granulosus hypothetical protein 0.0033 0.0322 0.0576
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0059 0.0059
Leishmania major cytochrome p450-like protein 0.0013 0.0093 0.0772
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0288 0.3244 1
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0069 0.0212
Entamoeba histolytica hypothetical protein 0.0011 0.0069 0.0588
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0062 0.066 0.1179
Toxoplasma gondii DNA topoisomerase 2, putative 0.0062 0.066 0.2033
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0069 0.0213
Schistosoma mansoni hypothetical protein 0.0205 0.2285 0.4087
Loa Loa (eye worm) hypothetical protein 0.006 0.0629 0.1435
Echinococcus granulosus cpg binding protein 0.0037 0.0366 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0069 0.0213
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0033 0.0273
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0059 0.0134
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.006 0.0108
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0343 0.0782
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0059 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0033 0.0075
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0343 0.0614
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0033 0.0101
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Trypanosoma brucei beta lactamase 0.0077 0.0826 0.685
Brugia malayi hypothetical protein 0.0039 0.0393 0.0895
Echinococcus granulosus expressed conserved protein 0.01 0.1093 0.1955
Brugia malayi Patched related family protein 12 0.0006 0.0021 0.0047
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0033 0.0038
Entamoeba histolytica hypothetical protein 0.0039 0.0393 0.3364
Mycobacterium ulcerans DNA gyrase subunit A 0.0288 0.3244 1
Schistosoma mansoni prokaryotic DNA topoisomerase 0.001 0.006 0.0107
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013 0.0093 0.0287
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Onchocerca volvulus 0.001 0.006 0.0186
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0033 0.0101
Echinococcus multilocularis tumor protein p63 0.0408 0.461 0.461
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0629 0.1125
Schistosoma mansoni apoferritin-2 0.001 0.0064 0.0114
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0093 0.0287
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0033 0.0273
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0033 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0033 0.0101
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0093 0.0772
Plasmodium falciparum DNA gyrase subunit B 0.0139 0.1532 0.469
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0052 0.0546 0.4531
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Schistosoma mansoni DNA ligase IV 0.0011 0.0069 0.0123
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0033 0.0101
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0084 0.0151
Entamoeba histolytica hypothetical protein 0.0039 0.0393 0.3364
Trichomonas vaginalis helicase, putative 0.0008 0.0036 0.0113
Brugia malayi hypothetical protein 0.0011 0.0069 0.0157
Toxoplasma gondii patched family protein 0.0006 0.0021 0.0063
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0033 0.0273
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0093 0.0287
Schistosoma mansoni inositol monophosphatase 0.0045 0.0456 0.0816
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0069 0.0213
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0241 0.2061
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0456 0.391
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0093 0.0287
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0408 0.0929
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0033 0.0075
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0241 0.0741
Loa Loa (eye worm) cytochrome P450 0.0013 0.0093 0.0212
Mycobacterium leprae putative cytochrome p450 0.0013 0.0093 0.0613
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0033 0.0102
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0397 0.3291
Onchocerca volvulus 0.0006 0.0021 0.0064
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0403 0.1242
Schistosoma mansoni smad 0.001 0.0059 0.0105
Schistosoma mansoni hypothetical protein 0.0044 0.0451 0.0807
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0241 0.2061
Leishmania major mitochondrial DNA topoisomerase II 0.011 0.1205 1
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0166 0.0512
Brugia malayi Pre-SET motif family protein 0.0037 0.0367 0.0837
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0166 0.0452
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Schistosoma mansoni ferritin light chain 0.001 0.0064 0.0114
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0069 0.0149
Loa Loa (eye worm) hypothetical protein 0.0026 0.0241 0.0548
Onchocerca volvulus 0.0026 0.0241 0.0746
Echinococcus multilocularis rho GTPase activating protein 20 0.001 0.006 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0033 0.0101
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0033 0.0075
Schistosoma mansoni hypothetical protein 0.0205 0.2285 0.4087
Mycobacterium ulcerans DNA topoisomerase I 0.001 0.006 0.0185
Loa Loa (eye worm) DNA topoisomerase III 0.001 0.006 0.0137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0322 0.0735
Schistosoma mansoni patched 1 0.0046 0.047 0.0841
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0033 0.0101
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0241 0.0741
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0113
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Plasmodium vivax DNA topoisomerase 3, putative 0.001 0.006 0.0122
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.001 0.006 0.0395
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013 0.0093 0.0287
Trichomonas vaginalis rotamase, putative 0.0039 0.0397 0.123
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0033 0.0101
Entamoeba histolytica DNA topoisomerase II, putative 0.0062 0.066 0.5651
Trypanosoma brucei DNA topoisomerase III, putative 0.001 0.006 0.0497
Echinococcus multilocularis geminin 0.0205 0.2285 0.2285
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0322 0.0735
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0033 0.0217
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0241 0.0741
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0033 0.0101
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013 0.0093 0.0287
Loa Loa (eye worm) hypothetical protein 0.0019 0.0166 0.0379
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013 0.0093 0.0287
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0069 0.0123
Brugia malayi CHE-14 protein 0.0046 0.047 0.1073
Brugia malayi Myosin head containing protein 0.0006 0.0021 0.0047
Schistosoma mansoni hypothetical protein 0.0033 0.0322 0.0576
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0033 0.0075
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.006 0.0108
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0075
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0033 0.0059
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013 0.0093 0.0287
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0113
Entamoeba histolytica hypothetical protein 0.0039 0.0393 0.3364
Brugia malayi DNA topoisomerase III 0.001 0.006 0.0137
Brugia malayi Patched protein homolog 1 0.0006 0.0021 0.0047
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0367 0.0657
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0077 0.0826 0.5438
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0008 0.0033 0.0217
Loa Loa (eye worm) inositol-1 0.0045 0.0456 0.1041
Leishmania major DNA topoisomerase III, putative 0.001 0.006 0.0497
Chlamydia trachomatis DNA gyrase subunit B 0.0091 0.0986 0.3041
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.1167 0.2662
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0241 0.1995
Brugia malayi DKFZp564C0469 protein 0.0011 0.0069 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0113
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0393 0.0702
Echinococcus granulosus Protein patched homolog 1 0.0046 0.047 0.0841
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0069 0.0588
Brugia malayi tumor suppressor. 0.0388 0.4385 1
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0157
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0093 0.0212
Trypanosoma cruzi DNA topoisomerase II, putative 0.0052 0.0546 0.4531
Onchocerca volvulus 0.0006 0.0021 0.0064
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.006 0.006
Onchocerca volvulus 0.0006 0.0021 0.0064
Schistosoma mansoni hypothetical protein 0.0033 0.0322 0.0576
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0093 0.0287
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0033 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0093 0.0287
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0062 0.066 0.066
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0241 0.0741
Mycobacterium ulcerans hypothetical protein 0.0026 0.0241 0.0741
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0113
Echinococcus granulosus smad 0.001 0.0059 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.047 0.1459
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0241 0.0548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0033 0.0101
Schistosoma mansoni Smad4 0.001 0.0059 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0113
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0069 0.0069
Schistosoma mansoni cpg binding protein 0.0037 0.0366 0.0654
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0033 0.0273
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0033 0.0101
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.002
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0062 0.066 0.1504
Chlamydia trachomatis DNA gyrase subunit A 0.0288 0.3244 1
Schistosoma mansoni topbp1 0.0011 0.0069 0.0123
Brugia malayi MH1 domain containing protein 0.001 0.0059 0.0134
Brugia malayi Cytochrome P450 family protein 0.0013 0.0093 0.0212
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0093 0.0287
Brugia malayi MH2 domain containing protein 0.0144 0.1594 0.3636
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.1186 0.2121
Schistosoma mansoni hypothetical protein 0.0013 0.0093 0.0167
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0069 0.0213
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0093 0.0287
Loa Loa (eye worm) hypothetical protein 0.0026 0.0241 0.0548
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5592 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.1691 0.1691
Mycobacterium ulcerans lipoprotein LpqF 0.0077 0.0826 0.2546
Echinococcus multilocularis smad 0.001 0.0059 0.0059
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.047 0.0841
Onchocerca volvulus 0.0006 0.0021 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0113
Loa Loa (eye worm) patched family protein 0.0006 0.0021 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0113
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0033 0.0075
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0154 0.0475
Chlamydia trachomatis DNA topoisomerase I 0.001 0.006 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0069 0.0569
Schistosoma mansoni ferritin 0.001 0.0064 0.0114
Leishmania major DNA topoisomerase ii 0.0052 0.0546 0.4531
Echinococcus multilocularis Smad4 0.001 0.0059 0.0059
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0069 0.0213
Loa Loa (eye worm) hypothetical protein 0.003 0.0289 0.0659
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0367 0.1132
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0069 0.0569
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0093 0.0287
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0069 0.0569
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0069 0.0212
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0139 0.1532 0.4625
Brugia malayi Pre-SET motif family protein 0.0252 0.2828 0.6448
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0019 0.0033
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013 0.0093 0.0287
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.0465
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0033 0.0038
Brugia malayi MH1 domain containing protein 0.0005 0.0009 0.002
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0397 0.3399
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0033 0.0273
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0241 0.1584
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0456 0.0456
Loa Loa (eye worm) patched family protein 0.0006 0.0021 0.0047
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0093 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0367 0.0657
Onchocerca volvulus 0.0008 0.0033 0.0102
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0033 0.0101
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0157
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0397 0.1223
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0288 0.3244 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Onchocerca volvulus 0.0006 0.0021 0.0064
Schistosoma mansoni prokaryotic DNA topoisomerase 0.001 0.006 0.0107
Trichomonas vaginalis ferritin, putative 0.001 0.0064 0.0197
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0033 0.0273
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Onchocerca volvulus 0.0012 0.0088 0.0272
Brugia malayi Cytochrome P450 family protein 0.0013 0.0093 0.0212
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0069 0.0452
Schistosoma mansoni smad1 5 8 and 0.001 0.0059 0.0105
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0093 0.0772
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0062 0.066 0.1504
Leishmania major DNA topoisomerase III, putative 0.001 0.006 0.0497
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0166 0.0452
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0093 0.0613
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0033 0.0101
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0397 0.3291
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Plasmodium vivax SET domain protein, putative 0.0037 0.0367 0.1075
Leishmania major cytochrome p450-like protein 0.0013 0.0093 0.0772
Echinococcus multilocularis expressed conserved protein 0.01 0.1093 0.1093
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0069 0.0569
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0033 0.0101
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.011 0.1205 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0397 0.3291
Onchocerca volvulus Protein patched homolog 0.0006 0.0021 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0033 0.0101
Schistosoma mansoni ferritin 0.001 0.0064 0.0114
Echinococcus granulosus muscleblind protein 0.018 0.2008 0.3591
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0093 0.0772
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013 0.0093 0.0287
Entamoeba histolytica hypothetical protein 0.0039 0.0393 0.3364
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0033 0.0101
Trichomonas vaginalis DNA topoisomerase II, putative 0.0062 0.066 0.2045
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.0033 0.0101
Schistosoma mansoni DNA topoisomerase II 0.0062 0.066 0.1179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0367 0.0657
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0033 0.0075
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013 0.0093 0.0287
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0093 0.0287
Brugia malayi Smad1 0.001 0.0059 0.0134
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.001 0.006 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0033 0.0101
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0069 0.0157
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013 0.0093 0.0287
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0113
Schistosoma mansoni smad1 5 8 and 0.001 0.0059 0.0105
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0367 0.0367
Brugia malayi GRF zinc finger family protein 0.001 0.006 0.0137
Echinococcus granulosus nibrin 0.0011 0.0069 0.0123
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013 0.0093 0.0287
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0241 0.0741
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0033 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0241 0.0741
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0033 0.0101
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0084 0.0192
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0059 0.0134
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0008 0.0033 0.0217
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.0087 0.0267
Brugia malayi Cytochrome P450 family protein 0.0059 0.062 0.1413
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0083 0.0189
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0087 0.072
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0093 0.0212
Echinococcus multilocularis ferritin 0.001 0.0064 0.0064
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0064 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0069 0.0213
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0113
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.1167 1
Schistosoma mansoni cytochrome P450 0.0013 0.0093 0.0167
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0093 0.0287
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0113
Trichomonas vaginalis rotamase, putative 0.004 0.0408 0.1264
Schistosoma mansoni ferritin light chain 0.001 0.0064 0.0114
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.1167 0.2087
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1594 0.3636
Plasmodium falciparum DNA topoisomerase 2 0.0062 0.066 0.1982
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.047 0.047
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0139 0.1532 0.4625
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013 0.0093 0.0287
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0456 0.3785
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0408 0.0929
Entamoeba histolytica DNA topoisomerase III, putative 0.001 0.006 0.0514
Echinococcus granulosus expressed protein 0.004 0.0408 0.0729
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0.0064 0.0011
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0069 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0241 0.0741
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.047 0.1073
Brugia malayi Muscleblind-like protein 0.018 0.2008 0.458
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Onchocerca volvulus 0.0035 0.0343 0.1064
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0367 0.0367
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0093 0.0772
Onchocerca volvulus 0.0008 0.0033 0.0102
Onchocerca volvulus 0.0006 0.0021 0.0064
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0069 0.0213
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0064 0.0011
Echinococcus granulosus DNA topoisomerase 3 alpha 0.001 0.006 0.0107
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0064 0.0196
Entamoeba histolytica DNA topoisomerase III, putative 0.001 0.006 0.0514
Loa Loa (eye worm) hypothetical protein 0.0046 0.047 0.1073
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0064 0.0196
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013 0.0093 0.0287
Schistosoma mansoni topbp1 0.0011 0.0069 0.0123
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.001 0.006 0.0186
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.0465
Brugia malayi Patched family protein 0.0006 0.0021 0.0047
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0069 0.1126
Loa Loa (eye worm) oxidoreductase 0.0008 0.0033 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0367 0.0657
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0367 0.0657
Brugia malayi DNA topoisomerase III beta-1 0.001 0.006 0.0137
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.016 0.1778 0.5482
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Toxoplasma gondii patched family protein 0.0006 0.0021 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0157
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0047
Echinococcus multilocularis nibrin 0.0011 0.0069 0.0069
Echinococcus multilocularis protein quaking 0.0033 0.0322 0.0322
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0093 0.0287
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0456 0.1245
Schistosoma mansoni apoferritin-2 0.001 0.0064 0.0114
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0241 0.0741

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (binding) 17.7828 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 25.7247 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2: Hit confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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