Detailed information for compound 1242123

Basic information

Technical information
  • TDR Targets ID: 1242123
  • Name: methyl 2-[[2-(4-chlorophenoxy)acetyl]amino]-1 -oxoisoquinoline-4-carboxylate
  • MW: 386.786 | Formula: C19H15ClN2O5
  • H donors: 1 H acceptors: 3 LogP: 2.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cn(NC(=O)COc2ccc(cc2)Cl)c(=O)c2c1cccc2
  • InChi: 1S/C19H15ClN2O5/c1-26-19(25)16-10-22(18(24)15-5-3-2-4-14(15)16)21-17(23)11-27-13-8-6-12(20)7-9-13/h2-10H,11H2,1H3,(H,21,23)
  • InChiKey: GPRLRCLKGCDSDY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • methyl 2-[[2-(4-chlorophenoxy)acetyl]amino]-1-oxo-isoquinoline-4-carboxylate
  • 2-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]-1-oxo-4-isoquinolinecarboxylic acid methyl ester
  • 2-[[2-(4-chlorophenoxy)acetyl]amino]-1-keto-isoquinoline-4-carboxylic acid methyl ester
  • methyl 2-[2-(4-chlorophenoxy)ethanoylamino]-1-oxo-isoquinoline-4-carboxylate
  • MLS000729872
  • SMR000308149
  • methyl 2-{[(4-chlorophenoxy)acetyl]amino}-1-oxo-1,2-dihydroisoquinoline-4-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei nitrate reductase, putative 0.0073 0.0562 0.0869
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0073 0.0562 0.0869
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0645 0.5523 1
Echinococcus granulosus cytochrome b5 reductase 4 0.0073 0.0562 0.1018
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0073 0.0562 0.1806
Leishmania major NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Leishmania major nitrate reductase, putative 0.0073 0.0562 0.0869
Brugia malayi PDZ domain containing protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0174 0.0174
Brugia malayi rho guanine nucleotide exchange factor 12 0.0017 0.0072 0.0072
Echinococcus multilocularis MAGUK p55 subfamily 0.0017 0.0072 0.0131
Schistosoma mansoni protein kinase 0.1161 1 1
Toxoplasma gondii flavodoxin domain-containing protein 0.032 0.2703 1
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0073 0.0562 0.1018
Leishmania major protein kinase, putative 0.0169 0.1395 0.2403
Brugia malayi jmjC domain containing protein 0.0019 0.009 0.009
Loa Loa (eye worm) flavodoxin family protein 0.0247 0.2067 0.2067
Brugia malayi Patj homolog 0.0017 0.0072 0.0072
Schistosoma mansoni jumonji domain containing protein 0.0019 0.009 0.009
Trypanosoma brucei eukaryotic translation initiation factor 2-alpha kinase 2 0.0143 0.1163 0.1974
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0111
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Schistosoma mansoni discs large 0.0017 0.0072 0.0072
Brugia malayi DIX domain containing protein 0.0017 0.0072 0.0072
Brugia malayi Guanylate kinase family protein 0.0021 0.0104 0.0104
Brugia malayi serine/threonine protein kinase 6 0.0061 0.0456 0.0456
Mycobacterium ulcerans monooxygenase 0.0073 0.0562 0.0833
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Echinococcus granulosus MAGUK p55 subfamily 0.0017 0.0072 0.0131
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0073 0.0562 0.0869
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0017 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Schistosoma mansoni cell polarity protein 0.0017 0.0072 0.0072
Plasmodium falciparum serine/threonine protein kinase, putative 0.0061 0.0456 0.0674
Echinococcus granulosus eukaryotic translation initiation factor 2 alpha 0.0169 0.1395 0.2527
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0073 0.0562 0.0869
Brugia malayi FAD binding domain containing protein 0.0398 0.3382 0.3382
Brugia malayi gopc protein 0.0017 0.0072 0.0072
Leishmania major reductase, putative 0.0073 0.0562 0.0869
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0017 0.0072 0.0131
Brugia malayi Peripheral plasma membrane protein CASK 0.0021 0.0104 0.0104
Brugia malayi RasGEF domain containing protein 0.0017 0.0072 0.0072
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0247 0.2067 0.3178
Trypanosoma brucei oxidoreductase-protein, putative 0.0073 0.0562 0.0869
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0542 0.0542
Echinococcus multilocularis cell polarity protein leucine rich repeat 0.0017 0.0072 0.0131
Schistosoma mansoni sh3 and multiple ankyrin repeat domains protein 12 (shank12) 0.0017 0.0072 0.0072
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0017 0.0072 0.0131
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0017 0.0072 0.0072
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.009 0.009
Echinococcus granulosus pdz domain containing protein 0.0017 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.009
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0073 0.0562 0.0869
Entamoeba histolytica protein kinase, putative 0.0061 0.0456 0.2206
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0072 0.0131
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0073 0.0562 0.0562
Trichomonas vaginalis STE family protein kinase 0.0143 0.1163 0.1394
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0072 0.0072
Toxoplasma gondii flavodoxin domain-containing protein 0.032 0.2703 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0073 0.0562 1
Brugia malayi flavodoxin family protein 0.0247 0.2067 0.2067
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0017 0.0072 0.0131
Plasmodium vivax flavodoxin domain containing protein 0.0572 0.4886 0.8829
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0072 0.0131
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0174 0.0116
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0073 0.0562 0.0869
Schistosoma mansoni cell polarity protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Schistosoma mansoni Patj homolog 0.0017 0.0072 0.0072
Echinococcus multilocularis Partitioning defective 3 protein B 0.0017 0.0072 0.0131
Loa Loa (eye worm) FAD binding domain-containing protein 0.0645 0.5523 0.5523
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0174 0.0116
Echinococcus multilocularis tight junction protein ZO 3 0.0017 0.0072 0.0131
Schistosoma mansoni leucine-rich repeat protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) PAR-6 protein 0.0017 0.0072 0.0072
Leishmania major protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative 0.0143 0.1163 0.1974
Plasmodium falciparum nitric oxide synthase, putative 0.0645 0.5523 1
Echinococcus multilocularis aurora kinase A 0.0061 0.0456 0.0827
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Echinococcus multilocularis MAGUK p55 subfamily 0.0017 0.0072 0.0131
Leishmania major NADH-dependent fumarate reductase-like protein 0.0073 0.0562 0.0869
Echinococcus granulosus partitioning defective 3 0.0017 0.0072 0.0131
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0645 0.5523 1
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0572 0.4886 0.8744
Schistosoma mansoni MAGUK homolog 0.0017 0.0072 0.0072
Echinococcus multilocularis eukaryotic translation initiation factor 2 alpha 0.0169 0.1395 0.2527
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0645 0.5523 1
Echinococcus granulosus disks large 1 0.0017 0.0072 0.0131
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.009 0.009
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0072 0.0131
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0017 0.0072 0.0131
Trypanosoma cruzi oxidoreductase-protein, putative 0.0073 0.0562 0.0869
Leishmania major NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Echinococcus granulosus glutamate receptor interacting protein 1 0.0017 0.0072 0.0131
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.009 0.0163
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0017 0.0072 0.0131
Schistosoma mansoni cell polarity protein 0.0017 0.0072 0.0072
Schistosoma mansoni protein kinase C alpha binding protein 0.0017 0.0072 0.0072
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0645 0.5523 1
Echinococcus granulosus multiple pdz domain protein 0.0017 0.0072 0.0131
Treponema pallidum flavodoxin 0.0247 0.2067 1
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0073 0.0562 0.0869
Brugia malayi Protein-tyrosine phosphatase 1 0.0017 0.0072 0.0072
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0174 0.084
Loa Loa (eye worm) PX domain-containing protein 0.0017 0.0072 0.0072
Onchocerca volvulus Huntingtin homolog 0.0148 0.121 1
Echinococcus granulosus myeloid:lymphoid or mixed lineage leukemia 0.0017 0.0072 0.0131
Brugia malayi serine/threonine-protein kinase 6 0.0061 0.0456 0.0456
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0247 0.2067 0.3638
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0017 0.0072 0.0131
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0247 0.2067 0.3638
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0017 0.0072 0.0072
Mycobacterium ulcerans electron transfer protein FdxB 0.0073 0.0562 0.0833
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0017 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Echinococcus granulosus Microtubule-associated serine/threonine-protein kinase 0.0022 0.0114 0.0207
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0017 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Brugia malayi hypothetical protein 0.0017 0.0072 0.0072
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0073 0.0562 0.0833
Chlamydia trachomatis sulfite reductase 0.0398 0.3382 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0072 0.0072
Echinococcus multilocularis 0.0017 0.0072 0.0131
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0017 0.0072 0.0131
Echinococcus granulosus amyloid beta A4 protein 0.0017 0.0072 0.0131
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.009 0.0163
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0174 0.1583
Echinococcus granulosus PRKCA binding protein 0.0017 0.0072 0.0131
Echinococcus granulosus rho guanine nucleotide exchange factor 12 0.0017 0.0072 0.0131
Loa Loa (eye worm) 9ORF binding protein 1 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Brugia malayi jmjC domain containing protein 0.0071 0.0542 0.0542
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0174 0.0155
Schistosoma mansoni protein kinase 0.0061 0.0456 0.0456
Brugia malayi PX domain containing protein 0.0017 0.0072 0.0072
Brugia malayi Syntrophin-1 0.0017 0.0072 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0174 0.0174
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0174 0.1583
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Echinococcus granulosus tight junction protein ZO 3 0.0017 0.0072 0.0131
Schistosoma mansoni pdz domain containing protein 0.0017 0.0072 0.0072
Echinococcus granulosus Rho GTPase activating protein 21 0.0017 0.0072 0.0131
Echinococcus granulosus beta 1 syntrophin 0.0017 0.0072 0.0131
Echinococcus multilocularis pdz domain containing protein 0.0017 0.0072 0.0131
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0645 0.5523 1
Echinococcus multilocularis myeloid:lymphoid or mixed lineage leukemia 0.0017 0.0072 0.0131
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0111 0.0119
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0072 0.0072
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0073 0.0562 0.0869
Schistosoma mansoni pdz and lim domain protein 0.0017 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Echinococcus multilocularis disks large 3 0.0017 0.0072 0.0131
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0111 0.022
Leishmania major protein kinase, putative 0.0061 0.0456 0.0674
Echinococcus granulosus ligand of numb protein x 2 0.0017 0.0072 0.0131
Echinococcus multilocularis partitioning defective 3 0.0017 0.0072 0.0131
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0073 0.0562 1
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0017 0.0072 0.0131
Brugia malayi Synapse defective protein 1 0.0017 0.0072 0.0072
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.009 0.0163
Schistosoma mansoni lim domain 0.0017 0.0072 0.0072
Loa Loa (eye worm) cell junction protein LIN-7 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0645 0.5523 0.5523
Echinococcus granulosus protein lin 7 B 0.0017 0.0072 0.0131
Schistosoma mansoni diflavin oxidoreductase 0.032 0.2703 0.2703
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0061 0.0456 0.2206
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0174 0.0116
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0017 0.0072 0.0131
Schistosoma mansoni syntrophin 0.0017 0.0072 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.009 0.009
Echinococcus multilocularis microtubule associated serine:threonine protein 0.0022 0.0114 0.0207
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0542 0.0982
Trypanosoma cruzi p450 reductase, putative 0.0073 0.0562 0.0869
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0073 0.0562 0.0562
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0017 0.0072 0.0131
Onchocerca volvulus 0.0073 0.0562 0.4307
Entamoeba histolytica type A flavoprotein, putative 0.0247 0.2067 1
Brugia malayi Ferm domain 0.0017 0.0072 0.0072
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0542 0.0982
Leishmania major p450 reductase, putative 0.0645 0.5523 1
Loa Loa (eye worm) AUR protein kinase 0.0061 0.0456 0.0456
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.0017 0.0072 0.0072
Schistosoma mansoni protein kinase 0.1161 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Echinococcus granulosus aurora kinase A 0.0061 0.0456 0.0827
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Giardia lamblia Nitric oxide synthase, inducible 0.0572 0.4886 1
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0073 0.0562 0.0869
Loa Loa (eye worm) AUR protein kinase 0.0061 0.0456 0.0456
Brugia malayi hypothetical protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0072 0.0072
Leishmania major NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Brugia malayi flavodoxin family protein 0.0645 0.5523 0.5523
Entamoeba histolytica type A flavoprotein, putative 0.0247 0.2067 1
Echinococcus multilocularis pdz domain containing protein 0.0017 0.0072 0.0131
Brugia malayi PDZ domain 0.0017 0.0072 0.0072
Mycobacterium tuberculosis Possible oxygenase 0.0073 0.0562 1
Entamoeba histolytica type A flavoprotein, putative 0.0247 0.2067 1
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0017 0.0072 0.0131
Schistosoma mansoni discs lost-related 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0029 0.0174 0.0174
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0017 0.0072 0.0072
Echinococcus granulosus multiple pdz domain protein 0.0017 0.0072 0.0131
Schistosoma mansoni leucine-rich repeat protein 0.0017 0.0072 0.0072
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0645 0.5523 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Echinococcus multilocularis protein piccolo 0.0017 0.0072 0.0131
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0073 0.0562 0.0833
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0061 0.0456 0.0827
Schistosoma mansoni ATP-dependent RNA Helicase 0.0017 0.0072 0.0072
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0247 0.2067 0.3638
Entamoeba histolytica type A flavoprotein, putative 0.0247 0.2067 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0174 0.084
Entamoeba histolytica protein kinase, putative 0.0061 0.0456 0.2206
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0073 0.0562 0.0869
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0542 0.0982
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Echinococcus granulosus multiple pdz domain protein 0.0017 0.0072 0.0131
Echinococcus multilocularis PDZ domain containing protein GIPC3 0.0017 0.0072 0.0131
Brugia malayi Hypothetical 13.5 kDa protein C45G9.7 in chromosome III 0.0017 0.0072 0.0072
Trypanosoma brucei protein kinase, putative 0.0169 0.1395 0.2403
Mycobacterium ulcerans oxidoreductase 0.0073 0.0562 0.0833
Brugia malayi cell junction protein LIN-7 0.0017 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0017 0.0072 0.0131
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0111 0.0039
Brugia malayi syntenin 0.0017 0.0072 0.0072
Loa Loa (eye worm) RasGEF domain-containing protein 0.0017 0.0072 0.0072
Brugia malayi Abnormal embryonic partitioning of cytoplasm protein 3 0.0017 0.0072 0.0072
Loa Loa (eye worm) DIX domain-containing protein 0.0017 0.0072 0.0072
Brugia malayi PDZ domain containing protein 0.0017 0.0072 0.0072
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.0456 0.2206
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0174 0.0174
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0017 0.0072 0.0131
Loa Loa (eye worm) FAD binding domain-containing protein 0.0398 0.3382 0.3382
Giardia lamblia Hypothetical protein 0.0572 0.4886 1
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0017 0.0072 0.0131
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0645 0.5523 1
Echinococcus granulosus cell polarity protein 0.0017 0.0072 0.0131
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0017 0.0072 0.0131
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0061 0.0456 0.2206
Echinococcus multilocularis cytochrome b5 reductase 4 0.0073 0.0562 0.1018
Brugia malayi jmjC domain containing protein 0.0019 0.009 0.009
Echinococcus granulosus cytochrome b5 reductase 4 0.0073 0.0562 0.1018
Schistosoma mansoni MAGUK homolog 0.0022 0.0114 0.0114
Brugia malayi PDZ domain containing protein 0.0017 0.0072 0.0072
Brugia malayi hypothetical protein 0.0169 0.1395 0.1395
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0022 0.0114 0.0207
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Plasmodium falciparum ferredoxin--NADP reductase 0.0073 0.0562 0.0869
Brugia malayi jmjC domain containing protein 0.0071 0.0542 0.0542
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0174 0.5
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0073 0.0562 0.0238
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0247 0.2067 0.3638
Brugia malayi Guanylate kinase family protein 0.0017 0.0072 0.0072
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.009 0.0163
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Echinococcus multilocularis rho guanine nucleotide exchange factor 12 0.0017 0.0072 0.0131
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0542 0.0542
Echinococcus granulosus methionine synthase reductase 0.0398 0.3382 0.6123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Trypanosoma brucei NADH-dependent fumarate reductase 0.0073 0.0562 0.0869
Loa Loa (eye worm) hypothetical protein 0.0029 0.0174 0.0174
Brugia malayi Neurabin protein 1 0.0017 0.0072 0.0072
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.009 0.0163
Echinococcus multilocularis neurabin 1 0.0017 0.0072 0.0131
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0542 0.0982
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0174 0.084
Echinococcus multilocularis multiple pdz domain protein 0.0017 0.0072 0.0131
Echinococcus granulosus MAGUK p55 subfamily 0.0017 0.0072 0.0131
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0017 0.0072 0.0131
Loa Loa (eye worm) gopc protein 0.0017 0.0072 0.0072
Echinococcus multilocularis Rho GTPase activating protein 21 0.0017 0.0072 0.0131
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0073 0.0562 0.0869
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.0143 0.1163 0.1974
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0645 0.5523 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.009
Brugia malayi diaphorase 0.0073 0.0562 0.0562
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0247 0.2067 0.3178
Echinococcus granulosus partitioning defective 3 0.0017 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0111
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Loa Loa (eye worm) syntrophin-1 0.0017 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Echinococcus multilocularis partitioning defective 3 0.0017 0.0072 0.0131
Echinococcus multilocularis pdz domain containing protein 0.0017 0.0072 0.0131
Schistosoma mansoni pdz domain containing protein 0.0017 0.0072 0.0072
Mycobacterium tuberculosis Probable oxidoreductase 0.0073 0.0562 1
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.0138 0.1121 0.1897
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.009 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0174 0.0116
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0247 0.2067 0.3178
Entamoeba histolytica protein kinase domain containing protein 0.0169 0.1395 0.6751
Echinococcus granulosus syndecan binding protein syntenin 0.0017 0.0072 0.0131
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0017 0.0072 0.0072
Trypanosoma cruzi aurora B kinase, putative 0.0061 0.0456 0.0674
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0073 0.0562 0.0869
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Echinococcus multilocularis methionine synthase reductase 0.0398 0.3382 0.6123
Echinococcus granulosus tyrosine protein kinase Lyn 0.0013 0.0042 0.0076
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Brugia malayi protein kinase C-binding protein PICK1 0.0017 0.0072 0.0072
Schistosoma mansoni tight junction protein 0.0017 0.0072 0.0072
Mycobacterium tuberculosis Probable monooxygenase 0.0073 0.0562 1
Entamoeba histolytica protein kinase domain containing protein 0.0169 0.1395 0.6751
Loa Loa (eye worm) hypothetical protein 0.0148 0.121 0.121
Schistosoma mansoni amyloid beta A4 protein related 0.0017 0.0072 0.0072
Loa Loa (eye worm) guanylate kinase 0.0021 0.0104 0.0104
Echinococcus granulosus phd:f box containing protein 0.0019 0.009 0.0163
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0017 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0017 0.0072 0.0131
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0022 0.0114 0.0207
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0111
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0398 0.3382 0.3382
Schistosoma mansoni dishevelled 0.0017 0.0072 0.0072
Echinococcus granulosus pdz domain containing protein 0.0017 0.0072 0.0131
Loa Loa (eye worm) PEK/PEK protein kinase 0.1161 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0174 0.0155
Trypanosoma cruzi p450 reductase, putative 0.0645 0.5523 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0174 0.0174
Echinococcus multilocularis MAGUK p55 subfamily 0.0017 0.0072 0.0131
Onchocerca volvulus 0.0029 0.0174 0.0898
Brugia malayi hypothetical protein 0.0017 0.0072 0.0072
Echinococcus granulosus MAGUK p55 subfamily 0.0017 0.0072 0.0131
Entamoeba histolytica protein kinase , putative 0.0061 0.0456 0.2206
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) X11 protein 0.0017 0.0072 0.0072
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0174 0.5
Echinococcus granulosus disks large 3 0.0017 0.0072 0.0131
Loa Loa (eye worm) guanylate kinase 0.0017 0.0072 0.0072
Brugia malayi hypothetical protein 0.0017 0.0072 0.0072
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0073 0.0562 0.0869
Onchocerca volvulus 0.0025 0.0146 0.0651
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0645 0.5523 1
Echinococcus multilocularis Na(+):H(+) exchange regulatory cofactor NHE RF2 0.0017 0.0072 0.0131
Schistosoma mansoni maguk P55 subfamily member 26 0.0017 0.0072 0.0072
Echinococcus granulosus Partitioning defective 3 protein B 0.0017 0.0072 0.0131
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0247 0.2067 0.3178
Echinococcus granulosus neurabin 1 0.0017 0.0072 0.0131
Brugia malayi PDZ domain 0.0017 0.0072 0.0072
Echinococcus multilocularis PRKCA binding protein 0.0017 0.0072 0.0131
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0061 0.0456 0.2206
Schistosoma mansoni maguk P55 subfamily member 35 0.0017 0.0072 0.0072
Schistosoma mansoni sap-97 0.0017 0.0072 0.0072
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0017 0.0072 0.0131
Plasmodium vivax serine/threonine protein kinase, putative 0.0143 0.1163 0.1974
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0073 0.0562 0.148
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Brugia malayi interleukin-16 0.0017 0.0072 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0542 0.0542
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0061 0.0456 0.0827
Brugia malayi PDZ domain containing protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0645 0.5523 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0073 0.0562 0.0869
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0017 0.0072 0.0072
Loa Loa (eye worm) AUR protein kinase 0.0061 0.0456 0.0456
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0072 0.0072
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0072 0.0072
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0174 0.0155
Echinococcus multilocularis pdz domain containing protein 0.0017 0.0072 0.0131
Entamoeba histolytica type A flavoprotein, putative 0.0247 0.2067 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0111
Schistosoma mansoni lin-7-like proteins 0.0017 0.0072 0.0072
Leishmania major cytochrome-b5 reductase, putative 0.0073 0.0562 0.0869
Echinococcus multilocularis ligand of numb protein x 2 0.0017 0.0072 0.0131
Loa Loa (eye worm) PEK/HRI protein kinase 0.0169 0.1395 0.1395
Schistosoma mansoni NADPH flavin oxidoreductase 0.0325 0.2745 0.2745
Schistosoma mansoni phd/f-box containing protein 0.0019 0.009 0.009
Echinococcus multilocularis protein lin 7 B 0.0017 0.0072 0.0131
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0456 0.0456
Loa Loa (eye worm) AGC/MAST/MAST protein kinase 0.0022 0.0114 0.0114
Echinococcus granulosus pdz domain containing protein 0.0017 0.0072 0.0131
Echinococcus multilocularis syndecan binding protein (syntenin) 0.0017 0.0072 0.0131
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Loa Loa (eye worm) hypothetical protein 0.0148 0.121 0.121
Loa Loa (eye worm) PDZ domain-containing protein 0.0017 0.0072 0.0072
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0061 0.0456 0.0674
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.009 0.009
Toxoplasma gondii aurora kinase 0.0061 0.0456 0.1402
Loa Loa (eye worm) diaphorase 0.0073 0.0562 0.0562
Leishmania major cytochrome P450 reductase, putative 0.0572 0.4886 0.8829
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0174 0.0116
Leishmania major NADH-dependent fumarate reductase, putative 0.0073 0.0562 0.0869
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0111
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0073 0.0562 0.1018
Schistosoma mansoni cytochrome P450 reductase 0.0645 0.5523 0.5523
Schistosoma mansoni syntenin 0.0017 0.0072 0.0072
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0542 0.0542
Brugia malayi gamma-syntrophin-like protein SYN2 0.0017 0.0072 0.0072
Echinococcus multilocularis phd:f box containing protein 0.0019 0.009 0.0163
Trypanosoma cruzi reductase, putative 0.0073 0.0562 0.0869
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0073 0.0562 0.0562
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0247 0.2067 0.3638
Echinococcus multilocularis amyloid beta A4 protein 0.0017 0.0072 0.0131
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0072 0.0131
Trichomonas vaginalis sulfite reductase, putative 0.0645 0.5523 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0645 0.5523 1
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0247 0.2067 0.3638
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0174 0.0116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Brugia malayi hypothetical protein 0.0017 0.0072 0.0072
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0073 0.0562 0.0869
Schistosoma mansoni afadin (af-6 protein) 0.0017 0.0072 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0247 0.2067 0.3638
Echinococcus multilocularis partitioning defective protein 6 0.0017 0.0072 0.0131
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0017 0.0072 0.0072
Brugia malayi hypothetical protein 0.0017 0.0072 0.0072
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0073 0.0562 0.1806
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0174 0.0116
Schistosoma mansoni protein phosphatase 2C 0.0019 0.009 0.009
Mycobacterium ulcerans hypothetical protein 0.0029 0.0174 0.0116
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0017 0.0072 0.0131
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0645 0.5523 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0645 0.5523 1
Trypanosoma brucei NADH-dependent fumarate reductase 0.0073 0.0562 0.0869
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0072 0.0131
Mycobacterium ulcerans oxygenase 0.0073 0.0562 0.0833
Trypanosoma brucei aurora B kinase 0.0061 0.0456 0.0674
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.009 0.0163
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Brugia malayi Partitioning defective-6 homolog alpha 0.0017 0.0072 0.0072
Brugia malayi FAD binding domain containing protein 0.0645 0.5523 0.5523
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.009
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0017 0.0072 0.0131
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.0143 0.1163 0.1974
Brugia malayi 9ORF binding protein 1 0.0017 0.0072 0.0072
Echinococcus granulosus Na:H exchange regulatory cofactor NHE RF2 0.0017 0.0072 0.0131
Schistosoma mansoni cell polarity protein 0.0017 0.0072 0.0072
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0017 0.0072 0.0072
Schistosoma mansoni PDZ domain protein 0.0017 0.0072 0.0072
Onchocerca volvulus Huntingtin homolog 0.0148 0.121 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Brugia malayi Shank2E 0.0017 0.0072 0.0072
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0072 0.0131
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0072 0.0072
Echinococcus granulosus pdz domain containing protein 0.0017 0.0072 0.0131
Brugia malayi hypothetical protein 0.0148 0.121 0.121
Brugia malayi jmjC domain containing protein 0.0019 0.009 0.009
Brugia malayi jmjC domain containing protein 0.0019 0.009 0.009
Schistosoma mansoni dishevelled 0.0017 0.0072 0.0072
Brugia malayi C2 domain containing protein 0.0017 0.0072 0.0072
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Echinococcus multilocularis beta 1 syntrophin 0.0017 0.0072 0.0131
Leishmania major hypothetical protein, conserved 0.0247 0.2067 0.3638
Echinococcus multilocularis multiple pdz domain protein 0.0017 0.0072 0.0131
Schistosoma mansoni cytochrome B5 0.0073 0.0562 0.0562
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0072
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0073 0.0562 0.0869
Trichomonas vaginalis AGC family protein kinase 0.0143 0.1163 0.1394
Echinococcus multilocularis disks large 1 0.0017 0.0072 0.0131
Brugia malayi PDZ-domain protein scribble 0.0017 0.0072 0.0072
Leishmania major oxidoreductase-like protein 0.0073 0.0562 0.0869
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.009 0.0163
Brugia malayi serine/threonine kinase 12 0.0061 0.0456 0.0456
Leishmania major cytochrome-b5 reductase, putative 0.0073 0.0562 0.0869
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Echinococcus multilocularis multiple pdz domain protein 0.0017 0.0072 0.0131
Trypanosoma brucei eukaryotic translation initiation factor 2-alpha kinase 1, putative 0.0169 0.1395 0.2403
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0111 0.0039
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0645 0.5523 1
Brugia malayi microtubule-associated serine/threonine protein kinase 2 (MAST2) 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0072
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.009 0.0163
Trypanosoma cruzi nitrate reductase, putative 0.0073 0.0562 0.0869

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0891 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.5686 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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