Detailed information for compound 1253929

Basic information

Technical information
  • TDR Targets ID: 1253929
  • Name: N-[2-[(4-methoxyphenyl)methylamino]-1-(4-meth ylphenyl)-2-oxoethyl]-N-(thiophen-2-ylmethyl) -2,3-dihydro-1,4-benzodioxine-7-carboxamide
  • MW: 542.645 | Formula: C31H30N2O5S
  • H donors: 1 H acceptors: 2 LogP: 5.18 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)CNC(=O)C(N(C(=O)c1ccc2c(c1)OCCO2)Cc1cccs1)c1ccc(cc1)C
  • InChi: 1S/C31H30N2O5S/c1-21-5-9-23(10-6-21)29(30(34)32-19-22-7-12-25(36-2)13-8-22)33(20-26-4-3-17-39-26)31(35)24-11-14-27-28(18-24)38-16-15-37-27/h3-14,17-18,29H,15-16,19-20H2,1-2H3,(H,32,34)
  • InChiKey: MXKVCRCITFDJEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(4-methoxyphenyl)methylamino]-1-(4-methylphenyl)-2-oxo-ethyl]-N-(2-thienylmethyl)-2,3-dihydro-1,4-benzodioxine-7-carboxamide
  • N-[2-[(4-methoxyphenyl)methylamino]-1-(4-methylphenyl)-2-oxoethyl]-N-(2-thienylmethyl)-2,3-dihydro-1,4-benzodioxine-7-carboxamide
  • N-[2-keto-2-[(4-methoxybenzyl)amino]-1-(4-methylphenyl)ethyl]-N-(2-thienylmethyl)-2,3-dihydro-1,4-benzodioxine-7-carboxamide
  • N-[2-[(4-methoxyphenyl)methylamino]-1-(4-methylphenyl)-2-oxo-ethyl]-N-(thiophen-2-ylmethyl)-2,3-dihydro-1,4-benzodioxine-7-carboxamide
  • Oprea1_815980
  • ASN 05344547
  • 2,3-Dihydro-benzo[1,4]dioxine-6-carboxylic acid [(4-methoxy-benzylcarbamoyl)-p-tolyl-methyl]-thiophen-2-ylmethyl-amide
  • MLS000568708
  • SMR000173059
  • Oprea1_594383

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0058 0.0403 0.2786
Brugia malayi Cytochrome P450 family protein 0.0097 0.0804 0.1598
Trichomonas vaginalis STE family protein kinase 0.0188 0.1759 0.5649
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0093 0.076 0.151
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.2923 1
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.076 0.0959
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0058 0.0403 0.0633
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0332 0.1767
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0863 0.1716
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.012 0.1048 0.4904
Loa Loa (eye worm) hypothetical protein 0.006 0.0423 0.0841
Onchocerca volvulus Glucosylceramidase homolog 0.0197 0.1848 1
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0402 0.0798
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.008 0.0626 0.0626
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0188 0.1759 0.1759
Schistosoma mansoni serine/threonine protein kinase 0.012 0.1048 0.1323
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0058 0.0403 0.0633
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.162 0.162
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0058 0.0403 0.0949
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0445 0.4434 0.8814
Plasmodium vivax serine/threonine kinase-1, putative 0.02 0.1879 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0368 0.0368
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.02 0.1879 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0368 0.0464
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0058 0.0403 0.2786
Brugia malayi Muscleblind-like protein 0.018 0.1675 0.333
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.2923 1
Echinococcus multilocularis tumor protein p63 0.0336 0.3297 0.3297
Giardia lamblia Kinase, CMGC MAPK 0.012 0.1048 0.4781
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.008 0.0626 0.1412
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1848 0.5979
Onchocerca volvulus 0.0058 0.0402 0.2174
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0631 0.2346
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0332 0.0419
Giardia lamblia Kinase, STE STE20 0.0188 0.1759 0.925
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0058 0.0403 0.2786
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0096 0.0795 0.0795
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0058 0.0403 0.0633
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.012 0.1048 0.4904
Echinococcus granulosus intermediate filament protein 0.0058 0.0402 0.0507
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0287 0.153
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.012 0.1048 0.4904
Loa Loa (eye worm) hypothetical protein 0.0043 0.0249 0.0494
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0631 0.2346
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0058 0.0403 0.0633
Entamoeba histolytica p21-activated kinase 0.0188 0.1759 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0058 0.0403 0.0633
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1848 0.5979
Loa Loa (eye worm) inositol-1 0.008 0.0631 0.1255
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0188 0.1759 0.1759
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0058 0.0403 0.2786
Echinococcus multilocularis muscleblind protein 0.018 0.1675 0.1675
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.008 0.0626 0.2317
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0058 0.0403 0.2786
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0423 0.0841
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.2923 1
Schistosoma mansoni protein kinase 0.0188 0.1759 0.2221
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0248 0.0248
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0058 0.0403 0.0633
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0096 0.0795 0.1004
Echinococcus multilocularis musashi 0.0058 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0043 0.0249 0.0494
Echinococcus multilocularis muscleblind protein 1 0.018 0.1675 0.1675
Brugia malayi MAP kinase sur-1 0.012 0.1048 0.2083
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0332 0.0311
Brugia malayi hypothetical protein 0.0502 0.5031 1
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1848 0.5979
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0446
Loa Loa (eye worm) hypothetical protein 0.0038 0.0196 0.039
Trichomonas vaginalis CMGC family protein kinase 0.012 0.1048 0.2989
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0058 0.0403 0.2786
Brugia malayi Protein kinase domain containing protein 0.02 0.1879 0.3734
Brugia malayi WH1 domain containing protein 0.0096 0.0795 0.1581
Loa Loa (eye worm) hypothetical protein 0.0502 0.5031 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0058 0.0403 0.2786
Schistosoma mansoni inositol monophosphatase 0.008 0.0631 0.0797
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0093 0.076 0.3135
Schistosoma mansoni protein kinase 0.0096 0.0795 0.1004
Schistosoma mansoni protein kinase 0.0188 0.1759 0.2221
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.269 1
Trichomonas vaginalis STE family protein kinase 0.0188 0.1759 0.5649
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0058 0.0403 0.2786
Brugia malayi P21-Rho-binding domain containing protein 0.0096 0.0795 0.1581
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0049 0.0308 0.0613
Entamoeba histolytica protein kinase, putative 0.01 0.0842 0.3926
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0058 0.0403 0.2786
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0058 0.0403 0.2786
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.012 0.0239
Echinococcus granulosus ubiquitin specific protease 41 0.008 0.0626 0.0791
Echinococcus multilocularis ubiquitin specific protease 41 0.008 0.0626 0.0626
Echinococcus multilocularis lamin dm0 0.0058 0.0402 0.0402
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0349 0.3435 0.3435
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.008 0.0626 0.2317
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0058 0.0403 0.0633
Echinococcus multilocularis 0.0195 0.1832 0.1832
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0248 0.0314
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.012 0.0239
Loa Loa (eye worm) hypothetical protein 0.008 0.0626 0.1245
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0058 0.0403 0.0949
Trichomonas vaginalis CMGC family protein kinase 0.012 0.1048 0.2989
Echinococcus multilocularis PAK box P21 Rho binding 0.0096 0.0795 0.0795
Brugia malayi serine/threonine-protein kinase PAK 7 0.0445 0.4434 0.8814
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0248 0.0314
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.008 0.0626 0.0626
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.008 0.0626 0.2131
Trichomonas vaginalis CMGC family protein kinase 0.012 0.1048 0.2989
Echinococcus multilocularis lamin 0.0058 0.0402 0.0402
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0058 0.0403 0.0633
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0058 0.0403 0.0633
Schistosoma mansoni lipoxygenase 0.0055 0.0368 0.0464
Schistosoma mansoni hypothetical protein 0.0096 0.0795 0.1004
Trypanosoma cruzi cytochrome P450, putative 0.0097 0.0804 0.3406
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0058 0.0403 0.2786
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.008 0.0626 0.1245
Echinococcus multilocularis dual specificity protein kinase clk2 0.02 0.1879 0.1879
Schistosoma mansoni hypothetical protein 0.0102 0.0863 0.109
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.056 0.0707
Mycobacterium leprae putative cytochrome p450 0.0058 0.0403 0.5245
Trichomonas vaginalis STE family protein kinase 0.0188 0.1759 0.5649
Trypanosoma brucei protein kinase, putative 0.012 0.1048 0.4904
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.02 0.1879 1
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.2923 1
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1848 0.5979
Echinococcus granulosus lamin 0.0058 0.0402 0.0507
Entamoeba histolytica protein kinase, putative 0.01 0.0842 0.3926
Brugia malayi Cytochrome P450 family protein 0.0097 0.0804 0.1598
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0332 0.0511
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0058 0.0403 0.0633
Loa Loa (eye worm) hypothetical protein 0.018 0.1675 0.333
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0058 0.0403 0.2786
Echinococcus multilocularis mitogen activated protein kinase 3 0.012 0.1048 0.1048
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0188 0.1759 0.2221
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0058 0.0403 0.2786
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0287 0.0258
Schistosoma mansoni hypothetical protein 0.0058 0.0403 0.0509
Onchocerca volvulus 0.0043 0.0249 0.1346
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.008 0.0631 0.5
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.02 0.1879 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0058 0.0403 0.2786
Toxoplasma gondii cytochrome p450 superfamily protein 0.0058 0.0403 0.0949
Echinococcus multilocularis mitogen activated protein kinase 0.012 0.1048 0.1048
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.056 0.056
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1848 0.5979
Echinococcus granulosus dual specificity protein kinase clk2 0.02 0.1879 0.2371
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0058 0.0403 0.0633
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.008 0.0626 0.0791
Giardia lamblia Kinase, CMGC CLK 0.02 0.1879 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.02 0.1879 0.3734
Echinococcus granulosus mitogen activated protein kinase 0.012 0.1048 0.1323
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0188 0.1759 0.2221
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.012 0.1048 0.2083
Loa Loa (eye worm) hypothetical protein 0.0184 0.1713 0.3405
Entamoeba histolytica protein kinase, putative 0.0188 0.1759 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0402 0.0798
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0423 0.0841
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.03 0.2923 0.581
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0631 0.2346
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0096 0.0795 0.1581
Schistosoma mansoni hypothetical protein 0.0096 0.0795 0.1004
Trypanosoma brucei cytochrome P450, putative 0.0097 0.0804 0.3406
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0072 0.0544 0.1208
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0249 0.0494
Schistosoma mansoni hypothetical protein 0.0205 0.1928 0.2434
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0058 0.0403 0.0633
Echinococcus granulosus hypothetical protein 0.0195 0.1832 0.2313
Loa Loa (eye worm) hypothetical protein 0.018 0.1675 0.333
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0332 0.0311
Echinococcus granulosus microtubule associated protein 2 0.078 0.7922 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0077 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1713 0.5475
Loa Loa (eye worm) acetyltransferase 0.0175 0.162 0.3219
Echinococcus multilocularis microtubule associated protein 2 0.078 0.7922 0.7922
Echinococcus multilocularis 0.0058 0.0403 0.0403
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.008 0.0626 0.0791
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.008 0.0626 0.2502
Echinococcus granulosus lamin dm0 0.0058 0.0402 0.0507
Schistosoma mansoni tyrosine kinase 0.0096 0.0795 0.1004
Echinococcus multilocularis inositol monophosphatase 1 0.008 0.0631 0.0631
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0058 0.0403 0.2786
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0058 0.0403 0.0949
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0058 0.0403 0.0633
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0096 0.0795 0.1004
Loa Loa (eye worm) cytochrome P450 family protein 0.0097 0.0804 0.1598
Onchocerca volvulus 0.0058 0.0402 0.2174
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0096 0.0795 0.1004
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0058 0.0403 0.2786
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0058 0.0403 0.0633
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0093 0.076 0.151
Brugia malayi beta-lactamase 0.0043 0.0249 0.0494
Loa Loa (eye worm) hypothetical protein 0.0043 0.0249 0.0494
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.1958 0.6392
Onchocerca volvulus 0.0102 0.0863 0.4674
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1848 0.5979
Leishmania major protein kinase, putative 0.02 0.1879 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0097 0.0804 0.1598
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0058 0.0403 0.0633
Echinococcus granulosus cytochrome P450 2K1 0.0058 0.0403 0.0509
Echinococcus multilocularis geminin 0.0205 0.1928 0.1928
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0349 0.3435 0.4336
Brugia malayi Cytochrome P450 family protein 0.0164 0.1507 0.2995
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0072 0.0544 1
Trichomonas vaginalis STE family protein kinase 0.0188 0.1759 0.5649
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.162 0.2044
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0093 0.076 0.151
Entamoeba histolytica hypothetical protein 0.0096 0.0795 0.3619
Mycobacterium leprae Conserved hypothetical protein 0.0058 0.0403 0.5245
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.008 0.0631 0.2346
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.056 0.5602
Brugia malayi Inositol-1 0.008 0.0631 0.1255
Schistosoma mansoni protein kinase 0.01 0.0842 0.1062
Trichomonas vaginalis inositol monophosphatase, putative 0.008 0.0631 0.143
Loa Loa (eye worm) hypothetical protein 0.0043 0.0249 0.0494
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0631 0.143
Trypanosoma cruzi p21-activated kinase 3, putative 0.0093 0.076 0.3135
Leishmania major cytochrome p450-like protein 0.0058 0.0403 0.0949
Echinococcus granulosus PAK box P21 Rho binding 0.0096 0.0795 0.1004
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0058 0.0403 0.0633
Echinococcus multilocularis PAK box P21 Rho binding 0.01 0.0842 0.0842
Echinococcus granulosus muscleblind protein 0.018 0.1675 0.2115
Echinococcus granulosus tumor protein p63 0.0336 0.3297 0.4162
Entamoeba histolytica hypothetical protein 0.0096 0.0795 0.3619
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0249 0.0314
Schistosoma mansoni inositol monophosphatase 0.008 0.0631 0.0797
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.056 0.5602
Brugia malayi intermediate filament protein 0.0058 0.0402 0.0798
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0332 0.0511
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0058 0.0403 0.0949
Leishmania major protein kinase, putative 0.02 0.1879 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0249 0.0249
Brugia malayi Cytochrome P450 family protein 0.0058 0.0403 0.0802
Schistosoma mansoni hypothetical protein 0.0096 0.0795 0.1004
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.02 0.1879 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0249 0.0494
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.012 0.1048 0.4904
Onchocerca volvulus 0.0043 0.0249 0.1346
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.056 0.1274
Schistosoma mansoni survival motor neuron protein 0.0102 0.0863 0.109
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0188 0.1759 0.1759
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0402 0.0798
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.056 0.1908
Brugia malayi hypothetical protein 0.0043 0.0248 0.0494
Schistosoma mansoni lamin 0.0058 0.0402 0.0507
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.056 0.1908
Brugia malayi cytochrome P450 0.0058 0.0403 0.0802
Trichomonas vaginalis CMGC family protein kinase 0.02 0.1879 0.6095
Schistosoma mansoni intermediate filament proteins 0.0058 0.0402 0.0507
Schistosoma mansoni hypothetical protein 0.0043 0.0248 0.0314
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.012 0.1048 0.4904
Loa Loa (eye worm) hypothetical protein 0.0028 0.0088 0.0175
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.076 0.0959
Loa Loa (eye worm) hypothetical protein 0.0027 0.0077 0.0153
Echinococcus multilocularis survival motor neuron protein 1 0.0502 0.5031 0.5031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.056 0.5602
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.008 0.0626 0.2317
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0626 0.1412
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0058 0.0403 0.2786
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1848 0.5979
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.008 0.0626 0.0791
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.2923 1
Trichomonas vaginalis STE family protein kinase 0.01 0.0842 0.2217
Brugia malayi beta-lactamase family protein 0.0043 0.0249 0.0494
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0058 0.0403 0.2786
Loa Loa (eye worm) hypothetical protein 0.0195 0.1832 0.3642
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0058 0.0403 0.2786
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0308 0.0389
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.008 0.0631 0.6888
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0188 0.1759 0.2221
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.02 0.1879 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0058 0.0403 0.0633
Loa Loa (eye worm) cytochrome P450 family protein 0.0164 0.1507 0.2995
Schistosoma mansoni hypothetical protein 0.0041 0.0225 0.0283
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0058 0.0403 0.0633
Loa Loa (eye worm) hypothetical protein 0.0057 0.0391 0.0776
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0058 0.0403 0.0633
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.02 0.1879 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0088 0.0111
Loa Loa (eye worm) CYP4Cod1 0.0097 0.0804 0.1598
Schistosoma mansoni hypothetical protein 0.0205 0.1928 0.2434
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0249 0.1324
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.056 0.0707
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0249 0.0314
Echinococcus granulosus mitogen activated protein kinase 3 0.012 0.1048 0.1323
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0631 0.143
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0097 0.0804 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.056 0.0707
Onchocerca volvulus 0.0043 0.0249 0.1346
Loa Loa (eye worm) beta-lactamase 0.0043 0.0249 0.0494
Leishmania major cytochrome p450-like protein 0.0097 0.0804 0.3406
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0093 0.076 0.1911
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1568 0.198
Brugia malayi Protein kinase domain 0.0188 0.1759 0.3497
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0631 0.2346
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.008 0.0626 0.0791
Plasmodium falciparum protein serine/threonine kinase-1 0.02 0.1879 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0225 0.0446
Leishmania major cytochrome p450-like protein 0.0058 0.0403 0.0949
Trichomonas vaginalis CMGC family protein kinase 0.012 0.1048 0.2989
Entamoeba histolytica myo-inositol monophosphatase, putative 0.008 0.0631 0.2533
Brugia malayi beta-lactamase family protein 0.0043 0.0249 0.0494
Schistosoma mansoni serine/threonine protein kinase 0.02 0.1879 0.2371
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0058 0.0403 0.0949
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.008 0.0626 0.1412
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0088 0.0713 0.0901
Loa Loa (eye worm) cytochrome P450 0.0058 0.0403 0.0802
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.162 0.3219
Onchocerca volvulus 0.0049 0.0308 0.1668
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.012 0.1048 0.4904
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0423 0.0841
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.1958 0.6392
Echinococcus granulosus inositol monophosphatase 1 0.008 0.0631 0.0797
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0058 0.0403 0.0633
Brugia malayi P21-Rho-binding domain containing protein 0.0096 0.0795 0.1581
Loa Loa (eye worm) hypothetical protein 0.0058 0.0402 0.0798
Trypanosoma cruzi cytochrome P450, putative 0.0097 0.0804 0.3406
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0058 0.0403 0.2786
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.2923 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0249 0.0494
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.03 0.2923 0.581
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.012 0.1048 0.4904
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.008 0.0626 0.2317
Entamoeba histolytica protein kinase, putative 0.01 0.0842 0.3926
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0249 0.0314
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.02 0.1879 1
Schistosoma mansoni cytochrome P450 0.0058 0.0403 0.0509
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.012 0.1048 0.4904
Echinococcus granulosus geminin 0.0205 0.1928 0.2434
Schistosoma mansoni serine/threonine protein kinase 0.02 0.1879 0.2371
Echinococcus granulosus survival motor neuron protein 1 0.0502 0.5031 0.6351
Loa Loa (eye worm) hypothetical protein 0.0043 0.0249 0.0494
Schistosoma mansoni microtubule-associated protein tau 0.078 0.7922 1
Schistosoma mansoni lamin 0.0058 0.0402 0.0507
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0795 0.1004

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.818382931 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.079457844 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.1259 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 0.1853 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.636 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.1962 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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