Detailed information for compound 1287754

Basic information

Technical information
  • TDR Targets ID: 1287754
  • Name: N-[1-(phenylmethyl)piperidin-4-yl]-2,3-dihydr o-1,4-benzodioxine-2-carboxamide
  • MW: 352.427 | Formula: C21H24N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1COc2c(O1)cccc2)NC1CCN(CC1)Cc1ccccc1
  • InChi: 1S/C21H24N2O3/c24-21(20-15-25-18-8-4-5-9-19(18)26-20)22-17-10-12-23(13-11-17)14-16-6-2-1-3-7-16/h1-9,17,20H,10-15H2,(H,22,24)
  • InChiKey: RDOZZKMGMCJBJF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[1-(phenylmethyl)-4-piperidyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
  • N-[1-(phenylmethyl)-4-piperidinyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
  • N-[1-(benzyl)-4-piperidyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
  • Oprea1_624687
  • 2,3-Dihydro-benzo[1,4]dioxine-2-carboxylic acid (1-benzyl-piperidin-4-yl)-amide
  • MLS000031203
  • BAS 05990553
  • SMR000013557

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Macaaca fascicularis T-complex protein 1 subunit beta Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Toxoplasma gondii t-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei gambiense T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Cryptosporidium parvum GroEL-like chaperone (ATpase); T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Theileria parva T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania donovani T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Cryptosporidium hominis TCP-1/cpn60 chaperonin-related protein Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium yoelii putative T-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium falciparum T-complex protein 1 subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Babesia bovis T-complex protein beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica T-complex protein 1 beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania infantum T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis chaperonin-60kD, ch60, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium berghei T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Neospora caninum TCP-1/cpn60 family chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Giardia lamblia TCP-1 chaperonin subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum ko:K09494 T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium vivax T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 550 aa 32.9 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.4 %
Plasmodium vivax T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Brugia malayi T-complex protein 1, eta subunit T-complex protein 1 subunit beta   535 aa 534 aa 33.1 %
Trypanosoma brucei gambiense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Plasmodium berghei T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 523 aa 30.2 %
Entamoeba histolytica chaperonin containing TCP-1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 508 aa 32.7 %
Drosophila melanogaster T-complex Chaperonin 5 T-complex protein 1 subunit beta   535 aa 506 aa 34.6 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 533 aa 28.3 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Plasmodium knowlesi T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 33.7 %
Trypanosoma brucei gambiense T-complex protein 1, theta subunit, putative,CCT-theta, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Trypanosoma brucei T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Trypanosoma brucei T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Plasmodium vivax T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.3 %
Plasmodium knowlesi T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 544 aa 23.5 %
Trypanosoma congolense T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 28.6 %
Babesia bovis T-complex protein 1 zeta subunit T-complex protein 1 subunit beta   535 aa 532 aa 26.7 %
Toxoplasma gondii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 531 aa 29.2 %
Plasmodium vivax heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 540 aa 21.9 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Leishmania donovani chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Leishmania braziliensis T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Leishmania infantum chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Babesia bovis heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 530 aa 22.3 %
Dictyostelium discoideum chaperonin containing TCP1 eta subunit T-complex protein 1 subunit beta   535 aa 528 aa 33.5 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Leishmania infantum T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 546 aa 33.7 %
Leishmania major T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 28.8 %
Leishmania braziliensis T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Entamoeba histolytica T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 29.9 %
Leishmania donovani T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Plasmodium knowlesi T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.1 %
Echinococcus multilocularis t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Plasmodium falciparum T-complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 546 aa 34.4 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, gamma subunit, tcpg, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Plasmodium yoelii T-complex protein 1 epsilon subunit T-complex protein 1 subunit beta   535 aa 508 aa 32.9 %
Echinococcus multilocularis T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Giardia lamblia TCP-1 chaperonin subunit zeta T-complex protein 1 subunit beta   535 aa 516 aa 24.8 %
Dictyostelium discoideum chaperonin containing TCP1 alpha subunit T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Plasmodium berghei T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 537 aa 23.5 %
Brugia malayi T-complex protein 1, epsilon subunit T-complex protein 1 subunit beta   535 aa 513 aa 31.4 %
Babesia bovis t-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Giardia lamblia TCP-1 chaperonin subunit theta T-complex protein 1 subunit beta   535 aa 563 aa 25.2 %
Cryptosporidium parvum putative T complex chaperonin T-complex protein 1 subunit beta   535 aa 546 aa 25.1 %
Plasmodium falciparum T-complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 542 aa 34.9 %
Leishmania braziliensis chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Leishmania infantum chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, beta subunit, tcpb, putative T-complex protein 1 subunit beta   535 aa 541 aa 35.5 %
Schistosoma mansoni chaperonin containing t-complex protein 1 epsilon subunit tcpe T-complex protein 1 subunit beta   535 aa 505 aa 33.9 %
Echinococcus granulosus chaperonin containing TCP1 subunit 5 epsilon T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Trypanosoma brucei gambiense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Theileria parva chaperonin 60 kDa, putative T-complex protein 1 subunit beta   535 aa 544 aa 26.1 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Leishmania major chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.3 %
Plasmodium falciparum T-complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 23.1 %
Giardia lamblia TCP-1 chaperonin subunit eta T-complex protein 1 subunit beta   535 aa 543 aa 32.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 545 aa 29.7 %
Trypanosoma brucei T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Leishmania major chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.1 %
Plasmodium falciparum T-complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 539 aa 23.4 %
Plasmodium berghei T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 526 aa 25.7 %
Leishmania braziliensis T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 29.1 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.2 %
Entamoeba histolytica chaperonin-containing TCP-1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 550 aa 23.5 %
Trypanosoma cruzi T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 29.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Brugia malayi T-complex protein 1, zeta subunit T-complex protein 1 subunit beta   535 aa 517 aa 27.7 %
Giardia lamblia TCP-1 chaperonin subunit alpha T-complex protein 1 subunit beta   535 aa 528 aa 32.6 %
Toxoplasma gondii T-complex protein 1 delta subunit T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Schistosoma japonicum ko:K09498 T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 552 aa 25.7 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Plasmodium knowlesi T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 526 aa 31.0 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Cryptosporidium hominis CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 536 aa 28.4 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 33.5 %
Cryptosporidium hominis CCTepsilon subunit T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Toxoplasma gondii T complex chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.0 %
Leishmania braziliensis chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 542 aa 26.2 %
Echinococcus granulosus t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma japonicum ko:K09497 T-complex protein 1 subunit epsilon, putative T-complex protein 1 subunit beta   535 aa 505 aa 33.5 %
Entamoeba histolytica T-complex protein 1 theta subunit, putative T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 561 aa 23.0 %
Trypanosoma brucei t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.6 %
Leishmania major T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.8 %
Cryptosporidium parvum conserved probable chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.7 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 579 aa 23.1 %
Leishmania braziliensis chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Babesia bovis HSP60 fold T-complex protein 1, putative T-complex protein 1 subunit beta   535 aa 497 aa 28.0 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 542 aa 27.7 %
Trypanosoma brucei gambiense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Theileria parva T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 580 aa 33.3 %
Leishmania major T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.3 %
Leishmania infantum T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Entamoeba histolytica chaperonin containing TCP-1 delta subunit, putative T-complex protein 1 subunit beta   535 aa 531 aa 30.7 %
Theileria parva T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 522 aa 32.4 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 575 aa 23.1 %
Babesia bovis TCP-1/cpn60 chaperonin family protein T-complex protein 1 subunit beta   535 aa 538 aa 30.5 %
Leishmania infantum T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.4 %
Trypanosoma cruzi T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 29.7 %
Leishmania donovani chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.5 %
Leishmania donovani chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Babesia bovis T-complex protein 1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 32.6 %
Trypanosoma brucei T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Schistosoma japonicum ko:K09493 T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 585 aa 31.5 %
Theileria parva T-complex protein 1, alpha subunit , putative T-complex protein 1 subunit beta   535 aa 527 aa 34.9 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 561 aa 27.1 %
Leishmania mexicana chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 538 aa 26.8 %
Schistosoma mansoni chaperonin containing t-complex protein 1 gamma subunit tcpg T-complex protein 1 subunit beta   535 aa 552 aa 29.7 %
Echinococcus granulosus T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 34.0 %
Leishmania infantum T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Schistosoma mansoni chaperonin containing t-complex protein 1 theta subunit tcpq T-complex protein 1 subunit beta   535 aa 515 aa 27.2 %
Trypanosoma congolense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 32.2 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Trichomonas vaginalis rubisco subunit binding-protein alpha subunit, ruba, putative T-complex protein 1 subunit beta   535 aa 580 aa 23.3 %
Schistosoma mansoni T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-complex protein 1 subunit beta   535 aa 552 aa 33.5 %
Entamoeba histolytica T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 31.6 %
Echinococcus multilocularis T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 27.1 %
Trypanosoma congolense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 521 aa 29.6 %
Echinococcus granulosus T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.5 %
Leishmania donovani T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Echinococcus granulosus T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Trypanosoma cruzi chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 528 aa 33.0 %
Cryptosporidium parvum TCP-1/cpn60 chaperonin family, T-complex protein subunit 7 (eta) T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Cryptosporidium hominis t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Entamoeba histolytica hypothetical protein T-complex protein 1 subunit beta   535 aa 516 aa 22.5 %
Leishmania mexicana chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.6 %
Plasmodium vivax T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 539 aa 22.4 %
Trypanosoma cruzi T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Plasmodium vivax T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Schistosoma japonicum ko:K09496 T-complex protein 1 subunit delta, putative T-complex protein 1 subunit beta   535 aa 533 aa 32.1 %
Trypanosoma cruzi chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 547 aa 26.0 %
Schistosoma mansoni chaperonin containing t-complex protein 1 delta subunit tcpd T-complex protein 1 subunit beta   535 aa 530 aa 32.8 %
Dictyostelium discoideum chaperonin containing TCP1 epsilon subunit T-complex protein 1 subunit beta   535 aa 520 aa 34.4 %
Leishmania major T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.5 %
Cryptosporidium hominis T-complex protein 1 T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Echinococcus multilocularis T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Schistosoma mansoni chaperonin containing t-complex protein 1 zeta subunit tcpz T-complex protein 1 subunit beta   535 aa 544 aa 26.3 %
Loa Loa (eye worm) T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 514 aa 26.5 %
Trypanosoma brucei gambiense T-complex protein 1, eta subunit, putative,t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.4 %
Echinococcus granulosus T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 517 aa 27.1 %
Plasmodium yoelii T-complex protein 1 T-complex protein 1 subunit beta   535 aa 534 aa 26.2 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 549 aa 35.7 %
Cryptosporidium parvum t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Schistosoma mansoni chaperonin containing t-complex protein 1 eta subunit tcph T-complex protein 1 subunit beta   535 aa 536 aa 32.8 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Trypanosoma congolense t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Brugia malayi T-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 529 aa 28.4 %
Trypanosoma brucei gambiense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Leishmania donovani T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Plasmodium yoelii putative chaperonin T-complex protein 1 subunit beta   535 aa 497 aa 22.7 %
Trypanosoma cruzi chaperonin/T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 30.9 %
Neospora caninum hypothetical protein T-complex protein 1 subunit beta   535 aa 531 aa 29.0 %
Trichomonas vaginalis chaperonin-60kD, ch60, putative T-complex protein 1 subunit beta   535 aa 538 aa 33.6 %
Plasmodium berghei T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 604 aa 22.9 %
Theileria parva T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 27.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Leishmania donovani T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, epsilon subunit, tcpe, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 533 aa 33.8 %
Mycobacterium tuberculosis 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (a T-complex protein 1 subunit beta   535 aa 565 aa 23.5 %
Toxoplasma gondii TCP-1 chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 26.9 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Toxoplasma gondii T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.8 %
Brugia malayi T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 502 aa 26.3 %
Trypanosoma congolense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 525 aa 34.1 %
Echinococcus multilocularis chaperonin containing TCP1, subunit 5 (epsilon) T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Schistosoma japonicum ko:K09499 T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 528 aa 20.8 %
Trypanosoma brucei gambiense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Toxoplasma gondii T-complex protein 1 eta subunit T-complex protein 1 subunit beta   535 aa 546 aa 33.9 %
Trypanosoma brucei T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Cryptosporidium parvum putative t-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 545 aa 28.3 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 550 aa 32.0 %
Trypanosoma congolense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.4 %
Leishmania mexicana T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.2 %
Plasmodium knowlesi T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.7 %
Loa Loa (eye worm) CCT-5 protein T-complex protein 1 subunit beta   535 aa 521 aa 31.3 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Cryptosporidium hominis chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.9 %
Neospora caninum Thermosome subunit, related T-complex protein 1 subunit beta   535 aa 527 aa 31.3 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Plasmodium vivax T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Leishmania mexicana chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.3 %
Leishmania mexicana T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.6 %
Onchocerca volvulus Integrator complex subunit 3 homolog T-complex protein 1 subunit beta   535 aa 534 aa 35.8 %
Leishmania major chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Toxoplasma gondii T-complex protein 1, epsilon subunit (TCP-1-epsilon), putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Plasmodium berghei T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 539 aa 34.1 %
Cryptosporidium parvum T complex chaperonin T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Dictyostelium discoideum chaperonin containing TCP1 theta subunit T-complex protein 1 subunit beta   535 aa 501 aa 27.1 %
Neospora caninum GL18351, related T-complex protein 1 subunit beta   535 aa 530 aa 26.2 %
Giardia lamblia TCP-1 chaperonin subunit epsilon T-complex protein 1 subunit beta   535 aa 535 aa 31.6 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 29.8 %
Plasmodium yoelii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 523 aa 30.0 %
Giardia lamblia TCP-1 chaperonin subunit gamma T-complex protein 1 subunit beta   535 aa 561 aa 29.8 %
Leishmania infantum chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Leishmania mexicana T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 35.1 %
Plasmodium yoelii chaperonin, 60 kDa T-complex protein 1 subunit beta   535 aa 530 aa 34.9 %
Leishmania braziliensis T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 547 aa 32.7 %
Dictyostelium discoideum chaperonin containing TCP1 zeta subunit T-complex protein 1 subunit beta   535 aa 523 aa 26.6 %
Plasmodium falciparum T-complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 522 aa 29.9 %
Brugia malayi T-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 534 aa 35.6 %
Drosophila melanogaster CG8351 gene product from transcript CG8351-RA T-complex protein 1 subunit beta   535 aa 527 aa 32.3 %
Trypanosoma brucei T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.4 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 549 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) sugar transporter 0.0013 0.0084 0.014
Echinococcus granulosus General substrate transporter 0.0077 0.1821 0.8364
Echinococcus granulosus zinc finger protein 0.002 0.0268 0.0889
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Schistosoma mansoni hypothetical protein 0.009 0.216 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.216 0.6974
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0814 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1343 0.6063
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0018 0.0217 0.0641
Plasmodium vivax lysine--tRNA ligase, putative 0.002 0.0283 0.0201
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1129 0.3511
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.094 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.094 1
Brugia malayi MH2 domain containing protein 0.0124 0.306 1
Toxoplasma gondii protein kinase, putative 0.0255 0.6571 1
Onchocerca volvulus 0.0013 0.0084 0.5
Trypanosoma brucei glucose transporter, putative 0.0028 0.0493 0.4786
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.009 0.216 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0886 0.2798
Brugia malayi lysyl-tRNA synthetase 0.002 0.0283 0.0671
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0013 0.0084 0.0891
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0182 0.0466
Toxoplasma gondii facilitative glucose transporter GT1 0.009 0.216 0.3201
Plasmodium falciparum calcium-dependent protein kinase 4 0.0028 0.0484 0.0404
Plasmodium vivax calcium-dependent protein kinase, putative 0.0028 0.0484 0.0404
Schistosoma mansoni glucose transport protein 0.009 0.216 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.002 0.0283 0.3015
Trypanosoma brucei ISWI complex protein 0.0015 0.0154 0.0818
Loa Loa (eye worm) hypothetical protein 0.0038 0.0772 0.2418
Schistosoma mansoni protein kinase 0.0028 0.0484 0.1927
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0029 0.0528 0.2137
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.094 1
Schistosoma mansoni protein kinase 0.0028 0.0484 0.1927
Onchocerca volvulus 0.0013 0.0084 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.216 0.9997
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0691 0.2039
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0814 1
Trypanosoma brucei glucose transporter, putative 0.0028 0.0493 0.4786
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0201 0.0563
Plasmodium vivax proline--tRNA ligase, putative 0.0032 0.0589 0.051
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0493 0.1973
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0182 0.0474
Onchocerca volvulus 0.0013 0.0084 0.5
Leishmania major glucose transporter, lmgt1 0.0028 0.0493 0.4786
Onchocerca volvulus 0.0013 0.0084 0.5
Echinococcus multilocularis calcium dependent protein kinase 0.0026 0.0438 0.1707
Trypanosoma brucei glucose transporter 2A 0.0028 0.0493 0.4786
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1129 0.3602
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.306 1
Mycobacterium ulcerans sugar transporter 0.0013 0.0084 0.0891
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.009 0.216 1
Loa Loa (eye worm) sugar transporter 0.009 0.216 0.7019
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0028 0.0484 0.1465
Trypanosoma cruzi hexose transporter, putative 0.0028 0.0493 0.4786
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.094 0.4121
Loa Loa (eye worm) hypothetical protein 0.0028 0.0484 0.1465
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0028 0.0484 0.1927
Onchocerca volvulus 0.0013 0.0084 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0333 0.0965
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0201 0.0563
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.009 0.216 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0297 0.0845
Trypanosoma cruzi ISWI complex protein 0.0015 0.0154 0.0818
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0028 0.0484 0.0404
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.009 0.216 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0706 0.2998
Giardia lamblia TCP-1 chaperonin subunit beta 0.0029 0.0528 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0029 0.0528 0.2137
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0029 0.0528 0.0448
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0028 0.0484 0.1927
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0528 0.2137
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.009 0.216 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.094 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0032 0.0589 0.0779
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0028 0.0484 0.1927
Trichomonas vaginalis glucose transporter, putative 0.0028 0.0493 0.1973
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0028 0.0484 0.0404
Entamoeba histolytica protein kinase, putative 0.0028 0.0484 0.3056
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Echinococcus multilocularis GPCR, family 2 0.0016 0.0182 0.0474
Plasmodium falciparum hexose transporter 0.009 0.216 0.2094
Mycobacterium ulcerans integral membrane transport protein 0.0013 0.0084 0.0891
Echinococcus multilocularis zinc finger protein 0.002 0.0268 0.0889
Schistosoma mansoni lysyl-tRNA synthetase 0.002 0.0283 0.0961
Plasmodium falciparum calcium-dependent protein kinase 2 0.0028 0.0484 0.0404
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1343 0.6063
Onchocerca volvulus 0.0013 0.0084 0.5
Onchocerca volvulus 0.0013 0.0084 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0484 0.1927
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0706 0.2998
Chlamydia trachomatis lysine--tRNA ligase 0.002 0.0283 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.094 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0201 0.0563
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0032 0.0589 0.5904
Schistosoma mansoni hypothetical protein 0.0016 0.0182 0.0474
Trypanosoma brucei glucose transporter, putative 0.0028 0.0493 0.4786
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0028 0.0484 0.1344
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0027 0.0469 0.4359
Loa Loa (eye worm) hypothetical protein 0.0027 0.0469 0.1416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.216 0.9997
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1129 0.3511
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.094 0.4121
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0028 0.0484 0.1465
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.094 0.4121
Giardia lamblia Lysyl-tRNA synthetase 0.002 0.0283 0.4497
Echinococcus granulosus calcium dependent protein kinase 0.0026 0.0438 0.1707
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0154 0.0816
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.094 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0017 0.0202 0.1619
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Brugia malayi PHD-finger family protein 0.0025 0.0411 0.11
Plasmodium falciparum calcium-dependent protein kinase 3 0.0028 0.0484 0.0404
Onchocerca volvulus 0.0013 0.0084 0.5
Onchocerca volvulus 0.0013 0.0084 0.5
Onchocerca volvulus 0.0013 0.0084 0.5
Brugia malayi Inositol-1 0.0045 0.094 0.2875
Plasmodium falciparum calcium-dependent protein kinase 1 0.0028 0.0484 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0028 0.0484 0.1927
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0028 0.0484 0.0404
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0182 0.0331
Trypanosoma brucei glucose transporter, putative 0.0028 0.0493 0.4786
Onchocerca volvulus 0.0013 0.0084 0.5
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0493 0.1973
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0028 0.0484 0.0617
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0528 0.1491
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0348 0.1271
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0028 0.0484 0.1927
Trypanosoma cruzi hexose transporter, putative 0.0028 0.0493 0.4786
Plasmodium falciparum lysine--tRNA ligase 0.002 0.0283 0.0201
Leishmania major glucose transporter, lmgt3 0.0028 0.0493 0.4786
Trypanosoma brucei THT1 - hexose transporter, putative 0.0028 0.0493 0.4786
Schistosoma mansoni hypothetical protein 0.0016 0.0182 0.0474
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.002 0.0283 0.2332
Leishmania major T-complex protein 1, beta subunit, putative 0.0029 0.0528 0.5186
Schistosoma mansoni glucose transport protein 0.009 0.216 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0032 0.0589 0.5904
Plasmodium falciparum calcium-dependent protein kinase 5 0.0028 0.0484 0.0404
Leishmania major hypothetical protein, conserved 0.0015 0.0154 0.0818
Trypanosoma brucei glucose transporter, putative 0.0028 0.0493 0.4786
Loa Loa (eye worm) hypothetical protein 0.0041 0.0835 0.2628
Loa Loa (eye worm) major facilitator superfamily transporter 0.0013 0.0084 0.014
Loa Loa (eye worm) hypothetical protein 0.0052 0.1129 0.3602
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0027 0.0469 0.1855
Onchocerca volvulus 0.0013 0.0084 0.5
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0283 0.0961
Loa Loa (eye worm) hypothetical protein 0.0016 0.0182 0.0466
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0013 0.0084 0.0891
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0028 0.0484 0.1927
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.216 0.7017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0469 0.1416
Trypanosoma brucei glucose transporter, putative 0.0028 0.0493 0.4786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.216 0.9997
Schistosoma mansoni hypothetical protein 0.0021 0.0297 0.1025
Plasmodium falciparum T-complex protein 1 subunit beta 0.0029 0.0528 0.0448
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0146 0.3649 0.3595
Schistosoma mansoni hypothetical protein 0.0035 0.0691 0.2923
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.216 0.9997
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.002 0.0283 0.2332
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Brugia malayi Sugar transporter family protein 0.009 0.216 0.6976
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0217 0.0582
Schistosoma mansoni protein kinase 0.0028 0.0484 0.1927
Schistosoma mansoni hypothetical protein 0.0016 0.0182 0.0474
Leishmania major glucose transporter/membrane transporter D2, putative 0.0028 0.0493 0.4786
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0028 0.0484 0.4675
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0028 0.0484 0.1927
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0201 0.0563
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0027 0.0469 0.1855
Plasmodium falciparum proline--tRNA ligase 0.0032 0.0589 0.051
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0528 0.2137
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0146 0.3649 0.5495
Loa Loa (eye worm) hypothetical protein 0.0071 0.1638 0.5288
Echinococcus multilocularis lysyl tRNA synthetase 0.002 0.0283 0.0961
Onchocerca volvulus 0.0013 0.0084 0.5
Trypanosoma cruzi hexose transporter, putative 0.0028 0.0493 0.4786
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0032 0.0589 0.5904
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0182 0.0474
Plasmodium vivax hexose transporter 0.009 0.216 0.2094
Trypanosoma brucei glucose transporter 1E 0.0028 0.0493 0.4786
Plasmodium falciparum mitogen-activated protein kinase 2 0.0146 0.3649 0.3595
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0017 0.0202 0.1619
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.094 0.1319
Schistosoma mansoni bromodomain containing protein 0.0063 0.1439 0.6525
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0029 0.0528 0.5186
Onchocerca volvulus 0.0013 0.0084 0.5
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0028 0.0484 0.0617
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0027 0.0469 0.1855
Loa Loa (eye worm) hypothetical protein 0.0035 0.0691 0.215
Trichomonas vaginalis chaperonin, putative 0.0029 0.0528 0.2137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.216 0.9997
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0027 0.0469 0.1294
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0201 0.0563
Trypanosoma cruzi hexose transporter 0.0028 0.0493 0.4786
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.094 1
Echinococcus multilocularis General substrate transporter 0.0077 0.1821 0.8364
Brugia malayi Bromodomain containing protein 0.0075 0.1753 0.5606
Brugia malayi Cam kinase protein 1 0.0028 0.0484 0.1344
Entamoeba histolytica protein kinase, putative 0.0028 0.0484 0.3056
Trypanosoma brucei THT1 - hexose transporter, putative 0.0028 0.0493 0.4786
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0028 0.0484 0.1927
Trypanosoma brucei glucose transporter, putative 0.0028 0.0493 0.4786
Loa Loa (eye worm) hypothetical protein 0.0017 0.0201 0.0527
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Onchocerca volvulus 0.0013 0.0084 0.5
Trichomonas vaginalis conserved hypothetical protein 0.009 0.216 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.094 0.4121
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.009 0.216 1
Schistosoma mansoni zinc finger protein 0.002 0.0268 0.0889
Plasmodium falciparum protein kinase 7 0.0255 0.6571 0.6542
Giardia lamblia Prolyl-tRNA synthetase 0.0027 0.0469 0.8678
Schistosoma mansoni hypothetical protein 0.0016 0.0182 0.0474
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0201 0.0563
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.009 0.216 1
Onchocerca volvulus Putative transporter 0.0013 0.0084 0.5
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.009 0.216 1
Schistosoma mansoni zinc finger protein 0.0015 0.0154 0.0337
Schistosoma mansoni hypothetical protein 0.0015 0.0154 0.0337
Schistosoma mansoni glucose transport protein 0.009 0.216 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0348 0.1271
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.094 0.4121
Loa Loa (eye worm) major facilitator superfamily transporter 0.0013 0.0084 0.014
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0032 0.0589 0.5904
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0528 0.2137
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0032 0.0589 0.5904
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0027 0.0469 0.1294
Trypanosoma brucei glucose transporter, putative 0.0028 0.0493 0.4786
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.306 1
Echinococcus granulosus GPCR family 2 0.0016 0.0182 0.0474
Toxoplasma gondii lysine-tRNA ligase 0.002 0.0283 0.0308
Trypanosoma brucei THT1 - hexose transporter, putative 0.0028 0.0493 0.4786
Leishmania major protein kinase, putative 0.0028 0.0484 0.4675
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0182 0.0474
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0182 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0484 0.1927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.216 0.9997
Schistosoma mansoni lysyl-tRNA synthetase 0.002 0.0283 0.0961
Toxoplasma gondii t-complex protein beta subunit 0.0029 0.0528 0.0684
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0201 0.0563
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.216 0.9997
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.014
Onchocerca volvulus 0.0013 0.0084 0.5
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0027 0.0469 0.1855
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0029 0.0528 0.5186
Echinococcus granulosus lysyl tRNA synthetase 0.002 0.0283 0.0961
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0348 0.1271
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0029 0.0528 0.2137
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0029 0.0528 0.3722
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0493 0.1973
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0528 0.1491
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0201 0.0563
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0027 0.0469 0.1855
Mycobacterium ulcerans lysyl-tRNA synthetase 0.002 0.0283 0.3015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0182 0.0474
Brugia malayi Bromodomain containing protein 0.0038 0.077 0.2304
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0493 0.1973
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0493 0.1973
Loa Loa (eye worm) T-complex protein 1 0.0029 0.0528 0.161
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0028 0.0484 0.0617
Trypanosoma cruzi ISWI complex protein 0.0015 0.0154 0.0818
Trichomonas vaginalis glucose transporter, putative 0.0028 0.0493 0.1973
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.002 0.0283 0.1328
Leishmania major lysyl-tRNA synthetase, putative 0.002 0.0283 0.2332
Loa Loa (eye worm) inositol-1 0.0045 0.094 0.2975
Leishmania major glucose transporter, lmgt2 0.0028 0.0493 0.4786
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.0801
Schistosoma mansoni inositol monophosphatase 0.0045 0.094 0.4121
Schistosoma mansoni inositol monophosphatase 0.0045 0.094 0.4121
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0027 0.0469 0.2828

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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