Detailed information for compound 1311943

Basic information

Technical information
  • TDR Targets ID: 1311943
  • Name: 1-[3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a] pyrimidin-6-yl]ethanone
  • MW: 285.728 | Formula: C15H12ClN3O
  • H donors: 0 H acceptors: 3 LogP: 2.66 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1cnn2c1ncc(c2C)C(=O)C
  • InChi: 1S/C15H12ClN3O/c1-9-13(10(2)20)7-17-15-14(8-18-19(9)15)11-3-5-12(16)6-4-11/h3-8H,1-2H3
  • InChiKey: GJIFEOFGHNWOJK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[3-(4-chlorophenyl)-7-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]ethanone
  • 1-[3-(4-chlorophenyl)-7-methyl-6-pyrazolo[1,5-a]pyrimidinyl]ethanone
  • MLS000528735
  • SMR000121210
  • 1-[3-(4-Chloro-phenyl)-7-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]-ethanone
  • BAS 05427521
  • ST062550
  • ZINC00794229

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0208
Echinococcus granulosus geminin 0.0337 0.079 0.3937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0025 0.0146
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.015 0.0879
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.015 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0142 0.0823
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0088 0.0509
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0021 0.0016 0.0079
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0073 0.0143 0.083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0088 0.0509
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0021 0.0016 0.0093
Schistosoma mansoni inositol monophosphatase 0.0038 0.0058 0.0286
Onchocerca volvulus 0.0099 0.0209 0.1226
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0121 0.06
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0088 0.0509
Loa Loa (eye worm) hypothetical protein 0.0072 0.0142 0.0823
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0036 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0088 0.0087
Brugia malayi Serine carboxypeptidase S28 family protein 0.0021 0.0016 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Schistosoma mansoni synaptojanin 0.0015 0.0003 0.0013
Trypanosoma brucei glucosidase, putative 0.0038 0.0059 0.3912
Trypanosoma brucei RNA editing exonuclease 2 0.0015 0.0003 0.0161
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0009 0.0562
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0088 0.0087
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0059 0.3912
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0058 0.0057
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0006 0.0118
Toxoplasma gondii cathepsin CPL 0.0016 0.0006 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0088 0.0509
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0009 0.0562
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0002
Onchocerca volvulus 0.0016 0.0006 0.0034
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0009 0.0043
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0036 0.0046
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0106 0.0226 0.1309
Toxoplasma gondii ABC1 family protein 0.0072 0.0142 0.7648
Loa Loa (eye worm) hypothetical protein 0.012 0.0258 0.1497
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0015 0.0003 0.0161
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0208
Onchocerca volvulus 0.0089 0.0185 0.1083
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0004 0.0004
Echinococcus granulosus neutral sphingomyelinase 0.0015 0.0003 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0509
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0009 0.0562
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0075 0.015 0.015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0009 0.0053
Onchocerca volvulus 0.0021 0.0016 0.0093
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0176
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0075 0.015 0.0378
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0088 0.0087
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0015 0.0003 0.0013
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0015 0.0003 0.0003
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0371
Schistosoma mansoni hypothetical protein 0.0337 0.079 0.3937
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0058
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.0387 0.2239
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0371
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0023 0.0136
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0059 0.011 0.7303
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0003 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Schistosoma mansoni inositol monophosphatase 0.0038 0.0058 0.0286
Plasmodium vivax SET domain protein, putative 0.0089 0.0185 1
Loa Loa (eye worm) hypothetical protein 0.02 0.0455 0.2634
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0328 0.0769 0.4451
Echinococcus granulosus histone lysine methyltransferase setb 0.0089 0.0185 0.092
Leishmania major hypothetical protein, conserved 0.0015 0.0003 0.0161
Schistosoma mansoni lamin 0.0106 0.0226 0.1126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0328 0.0769 0.3832
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0018 0.0835
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0142 0.0357
Loa Loa (eye worm) hypothetical protein 0.0102 0.0215 0.1242
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0059 0.0346
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0059 0.0346
Schistosoma mansoni alpha-glucosidase 0.0148 0.0328 0.1634
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0088 0.0087
Loa Loa (eye worm) DR-78 0.0024 0.0023 0.0136
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0088 0.0436
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0509
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Giardia lamblia Serine peptidase, putative 0.0021 0.0016 0.089
Brugia malayi nuclear hormone receptor 0.005 0.0088 0.0509
Brugia malayi Smad1 0.0025 0.0028 0.0159
Schistosoma mansoni transcription factor LCR-F1 0.0217 0.0498 0.2482
Echinococcus granulosus cathepsin l1 0.0016 0.0006 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0023 0.0023
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0018
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0 0.0002
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0059 0.1183
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0003 0.0054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0088 0.0436
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0036 0.0715
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0075 0.015 0.0747
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0208
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0142 0.0832
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0088 0.0087
Onchocerca volvulus Putative neutral sphingomyelinase 0.0015 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0063 0.0121 0.0699
Schistosoma mansoni Smad4 0.0025 0.0028 0.0135
Loa Loa (eye worm) hypothetical protein 0.0072 0.0142 0.0823
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0208
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.003 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0088 0.0436
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0058 0.3008
Brugia malayi tailless protein 0.0024 0.0023 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0371
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0387 0.0386
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0001 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.012 0.7938
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.015 1
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0025 0.1218
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0015 0.0003 0.0161
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0034
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0003 0.0161
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0059 0.011 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Brugia malayi MH2 domain containing protein 0.037 0.087 0.5039
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0003 0.0054
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0003 0.0161
Brugia malayi RNA binding protein 0.0198 0.0451 0.2611
Brugia malayi MH1 domain containing protein 0.0025 0.0028 0.0159
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0 0.0002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0075 0.015 0.9974
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0021 0.0016 0.0317
Brugia malayi nuclear receptor RXR 0.0026 0.003 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0088 0.0436
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0028 0.0027
Schistosoma mansoni hypothetical protein 0.0217 0.0498 0.2482
Treponema pallidum exodeoxyribonuclease (exoA) 0.0075 0.015 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0025 0.1638
Leishmania major cathepsin L-like protease 0.0063 0.012 0.7938
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0003 0.0161
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0075 0.015 0.3008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.0455 0.2634
Echinococcus granulosus Smad4 0.0025 0.0028 0.0135
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0 0.0002
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0006 0.0214
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0059 0.309
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0034
Loa Loa (eye worm) RNA binding protein 0.0198 0.0451 0.2611
Brugia malayi hypothetical protein 0.0049 0.0085 0.0493
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0142 0.9444
Schistosoma mansoni hypothetical protein 0.0063 0.0121 0.06
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0009 0.0562
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0004 0.0231
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0009 0.033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0075 0.015 0.0869
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0013
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0176
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0049 0.0241
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0106
Schistosoma mansoni neutral sphingomyelinase 0.0015 0.0003 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.003 0.0176
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0153 0.0886
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0088 0.0509
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0088 0.0436
Echinococcus multilocularis survival motor neuron protein 1 0.072 0.1727 0.1726
Loa Loa (eye worm) cysteine protease 0.0016 0.0006 0.0036
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0009 0.0053
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0021 0.0016 0.0093
Leishmania major endonuclease/exonuclease protein-like protein 0.0015 0.0003 0.0161
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0059 0.0346
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0142 0.0357
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0088 0.0436
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0088 0.0513
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0004 0.0231
Mycobacterium ulcerans hypothetical protein 0.0029 0.0036 0.0046
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0025 0.0124
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0021 0.0016 0.1034
Brugia malayi MH2 domain containing protein 0.0025 0.0028 0.0159
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0002
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0059 0.011 0.5885
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0075 0.015 1
Leishmania major hypothetical protein, conserved 0.0015 0.0003 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0006 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0004 0.0058
Brugia malayi Pre-SET motif family protein 0.0624 0.1492 0.8643
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0009 0.0175
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0018 0.0039
Schistosoma mansoni zinc finger protein 0.0024 0.0023 0.0115
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Mycobacterium leprae Probable lipase LipE 0.0072 0.0142 0.0275
Echinococcus granulosus intermediate filament protein 0.0106 0.0226 0.1126
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0142 0.0823
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0028 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0003 0.0054
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0015 0.0003 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.015 0.0879
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0143 0.0713
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.015 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Brugia malayi steroid hormone receptor 0.005 0.0088 0.0509
Schistosoma mansoni hypothetical protein 0.0063 0.0121 0.06
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0009 0.0562
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0059 0.0346
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0088 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0088 0.0509
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0328 0.0769 0.4451
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0018
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0018
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0018 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0088 0.0509
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0006 0.0352
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0009 0.0053
Brugia malayi hypothetical protein 0.0024 0.0023 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Echinococcus multilocularis traf and tnf receptor associated protein 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0106
Brugia malayi MH2 domain containing protein 0.0025 0.0028 0.0159
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0017 0.1084
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0046
Onchocerca volvulus Huntingtin homolog 0.012 0.0258 0.1515
Schistosoma mansoni nuclear receptor 0.0024 0.0023 0.0115
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0 0.0002
Giardia lamblia GTOR 0.0018 0.0009 0.0409
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0049 0.0048
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.03 0.1738
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0142 0.0357
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0088 0.0436
Schistosoma mansoni thyroid hormone receptor 0.005 0.0088 0.0436
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0003 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0142 0.9444
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0088 0.0436
Leishmania major cathepsin L-like protease 0.0063 0.012 0.7938
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0328 0.0769 0.0768
Brugia malayi prolyl oligopeptidase family protein 0.0059 0.011 0.0637
Brugia malayi hypothetical protein 0.0217 0.0498 0.2883
Brugia malayi TAR-binding protein 0.0198 0.0451 0.2611
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0003 0.0161
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0009 0.0009
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0004 0.0019
Echinococcus granulosus Dipeptidyl peptidase 9 0.0059 0.011 0.0547
Loa Loa (eye worm) hypothetical protein 0.0072 0.0142 0.0823
Mycobacterium ulcerans TetR family transcriptional regulator 0.1606 0.3894 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0328 0.0769 0.3832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0023 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0034
Brugia malayi ecdysone receptor 0.0024 0.0023 0.0136
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.015 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.072 0.1727 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0018
Brugia malayi nuclear receptor NHR-88 0.005 0.0088 0.0509
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0036 0.0046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0198 0.0451 0.2611
Loa Loa (eye worm) hypothetical protein 0.012 0.0258 0.1497
Brugia malayi beta-lactamase family protein 0.0072 0.0142 0.0823
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0006
Brugia malayi MH1 domain containing protein 0.0025 0.0028 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0059 0.3912
Leishmania major RNA-editing complex protein MP100, putative 0.0015 0.0003 0.0161
Schistosoma mansoni smad 0.0025 0.0028 0.0135
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0048 0.0116
Schistosoma mansoni smad1 5 8 and 0.0025 0.0028 0.0135
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0028 0.0135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0088 0.0509
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0175 0.0395 0.2315
Schistosoma mansoni cript-related 0.0015 0.0003 0.0013
Schistosoma mansoni coup transcription factor 0.005 0.0088 0.0436
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0023 0.0135
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0009 0.0009
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0036
Onchocerca volvulus 0.0016 0.0006 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0072 0.0142 0.0823
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0142 0.0707
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0094
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0142 0.0357
Loa Loa (eye worm) hypothetical protein 0.0137 0.03 0.1738
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0036 0.0715
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0015 0.0003 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0088 0.0509
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0006 0.0034
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2005 0.2005
Schistosoma mansoni nuclear hormone receptor 0.005 0.0088 0.0436
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0106
Schistosoma mansoni thyroid hormone receptor 0.005 0.0088 0.0436
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0143 0.9528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0009 0.0562
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0006
Schistosoma mansoni nuclear receptor 0.0024 0.0023 0.0115
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0059 0.0346
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0003 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.0455 0.2634
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0451 0.2247
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0006
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0142 0.032
Onchocerca volvulus 0.0102 0.0215 0.1257
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0009 0.0562
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Echinococcus multilocularis lamin dm0 0.0106 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0509
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0025 0.0146
Loa Loa (eye worm) hypothetical protein 0.0075 0.015 0.0871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0046
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0023 0.0136
Brugia malayi Ets-domain containing protein 0.0076 0.0153 0.0886
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0231
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0036
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0023 0.0136
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0004 0.0003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0075 0.015 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0003 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0451 0.2247
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Brugia malayi CCR4 0.0015 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0106
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0143 0.0143
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0006 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0048 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0034
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0015 0.0003 0.0054
Echinococcus multilocularis smad 0.0025 0.0028 0.0027
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0 0.0002
Brugia malayi beta-lactamase 0.0072 0.0142 0.0823
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Brugia malayi nuclear receptor RXR 0.0024 0.0023 0.0136
Brugia malayi RNA recognition motif domain containing protein 0.0198 0.0451 0.2611
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0075 0.015 0.034
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0028 0.0027
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0121 0.012
Loa Loa (eye worm) fibroinase 0.0016 0.0006 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0142 0.0832
Loa Loa (eye worm) hypothetical protein 0.0065 0.0126 0.0729
Schistosoma mansoni hypothetical protein 0.0063 0.0121 0.06
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0088 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Onchocerca volvulus Huntingtin homolog 0.012 0.0258 0.1515
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0143 0.084
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0087 0.5743
Mycobacterium tuberculosis Possible penicillin-binding protein 0.046 0.1092 0.2797
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0073 0.0143 0.083
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.003 0.0149
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0073 0.0143 0.9545
Brugia malayi intermediate filament protein 0.0106 0.0226 0.1309
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Brugia malayi hypothetical protein 0.0026 0.003 0.0176
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0142 0.0707
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0106
Leishmania major hypothetical protein, conserved 0.0015 0.0003 0.0161
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0003 0.0161
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0016 0.0006 0.0032
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0059 0.1183
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0058 0.1153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Echinococcus granulosus ubiquitin specific protease 41 0.0073 0.0143 0.0713
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0143 0.9528
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0009 0.0175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0034
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0509
Echinococcus multilocularis neutral sphingomyelinase 0.0015 0.0003 0.0003
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0028 0.0159
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0624 0.1492 0.8643
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0025 0.1638
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0059 0.3912
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0059 0.0346
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0036 0.0715
Entamoeba histolytica hypothetical protein 0.0217 0.0498 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0032
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0142 0.0357
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.015 0.8106
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0021 0.0016 0.0016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0177 0.088
Trichomonas vaginalis esterase, putative 0.0072 0.0142 0.0832
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0059 0.0346
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.0185 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0019
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.3812
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0142 0.032
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0009 0.0043
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0003 0.0161
Schistosoma mansoni intermediate filament proteins 0.0106 0.0226 0.1126
Brugia malayi Ets-domain containing protein 0.0076 0.0153 0.0886
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0023 0.0023
Echinococcus granulosus GPCR family 2 0.0063 0.0121 0.06
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0121 0.0699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0153 0.0761
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0006 0.0029
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0023 0.0136
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0009 0.0053
Loa Loa (eye worm) beta-lactamase 0.0072 0.0142 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0023 0.0115
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0088 0.0509
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0009 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Onchocerca volvulus 0.005 0.0088 0.0513
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0142 0.0832
Echinococcus granulosus traf and tnf receptor associated protein 0.0015 0.0003 0.0013
Trichomonas vaginalis Phospholipase C precursor, putative 0.0015 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0051 0.0091 0.053
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0 0.0002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0001 0.0004
Loa Loa (eye worm) intermediate filament protein 0.0106 0.0226 0.1309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Schistosoma mansoni ets-related 0.0232 0.0534 0.266
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0098
Onchocerca volvulus 0.0147 0.0325 0.1907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0509
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.003 0.003
Echinococcus multilocularis GPCR, family 2 0.0063 0.0121 0.012
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0003 0.0003
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0006 0.0214
Brugia malayi ecdysteroid receptor 0.005 0.0088 0.0509
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0153 0.0153
Entamoeba histolytica hypothetical protein 0.0024 0.0025 0.0499
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0032
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0059 0.0346
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0176
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.3812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Mycobacterium ulcerans beta-lactamase 0.0072 0.0142 0.032
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0036
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0003 0.0054
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0023 0.0115
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0028 0.0159
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0371
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1606 0.3894 1
Brugia malayi hypothetical protein 0.0026 0.003 0.0176
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.0387 0.1927
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0 0.0002
Leishmania major cathepsin L-like protease 0.0063 0.012 0.7938
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0006 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.0093
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0004 0.0004
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0018
Brugia malayi hypothetical protein 0.0014 0 0.0002
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0009 0.0562
Brugia malayi exodeoxyribonuclease III family protein 0.0075 0.015 0.0869
Trichomonas vaginalis set domain proteins, putative 0.071 0.1703 1
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0023 0.0115
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0015 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Brugia malayi hypothetical protein 0.0075 0.015 0.0871
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.003 0.0149
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0003 0.0054
Schistosoma mansoni ap endonuclease 0.0075 0.015 0.0747
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.0455 0.2634
Echinococcus multilocularis tar DNA binding protein 0.0198 0.0451 0.045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0088 0.0087
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0023 0.0115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0075 0.015 0.9974
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0015 0.0003 0.0054
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0023 0.0023
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.015 0.9974
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0058 0.0337
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0023 0.0023
Brugia malayi Cytochrome P450 family protein 0.0047 0.0081 0.0472
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0018
Plasmodium vivax vivapain-2 0.0016 0.0006 0.0174
Schistosoma mansoni hypothetical protein 0.0034 0.0049 0.0241
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0509
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0003 0.0054
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0175 0.0395 0.0394
Echinococcus multilocularis deoxyribonuclease 1 2 0.0015 0.0003 0.0003
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0059 0.011 0.7303
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0088 0.0509
Brugia malayi hypothetical protein 0.072 0.1727 1
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0015 0.0003 0.0161
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0382 0.0901 0.4493
Brugia malayi hypothetical protein 0.016 0.0358 0.2074
Brugia malayi prolyl oligopeptidase family protein 0.0175 0.0395 0.2286
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0088 0.0087
Brugia malayi Pre-SET motif family protein 0.0089 0.0185 0.1071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0088 0.0509
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0081 0.0472
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0142 0.7648
Onchocerca volvulus 0.016 0.0358 0.21
Loa Loa (eye worm) fli-1 protein 0.0232 0.0534 0.309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Schistosoma mansoni alpha-glucosidase 0.0148 0.0328 0.1634
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.015 0.8106
Loa Loa (eye worm) ctsf protein 0.0016 0.0006 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0143 0.084
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0015 0.0003 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0089 0.0185 0.0184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0088 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0075 0.015 0.9974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0143 0.9528
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0143 0.0143
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0088 0.0436
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0009 0.0562
Onchocerca volvulus 0.0072 0.0142 0.0832
Leishmania major hypothetical protein, conserved 0.0072 0.0142 0.9444
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0371
Loa Loa (eye worm) hypothetical protein 0.0104 0.0221 0.1282
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0509
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0088 0.0436
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0006 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0185 0.092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0121 0.06
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0032
Echinococcus granulosus lamin 0.0106 0.0226 0.1126
Loa Loa (eye worm) hypothetical protein 0.016 0.0358 0.2074
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0073 0.0143 0.0713
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0034
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0004 0.0072
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0015 0.0003 0.0016
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0006 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0142 0.0832
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0023 0.0115
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0003 0.0161
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0023 0.0115
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Echinococcus multilocularis tumor protein p63 0.0694 0.1664 0.1664
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0231
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0006 0.0352
Loa Loa (eye worm) prolyl oligopeptidase 0.0175 0.0395 0.2286
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.037 0.087 0.5039
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0051 0.0091 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0057 0.0105 0.061
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0023 0.0115
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0075 0.015 0.9974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0023 0.0115
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0059 0.0343
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0002
Schistosoma mansoni hypothetical protein 0.0063 0.0121 0.06
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Schistosoma mansoni hypothetical protein 0.0337 0.079 0.3937
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0015 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0217 0.0498 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0003 0.0161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0034
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.3812
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0009 0.0562
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0003 0.0161
Brugia malayi nuclear hormone receptor 0.0024 0.0023 0.0136
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0231
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.003 0.0149
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0021 0.0016 0.0317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0088 0.0509
Mycobacterium ulcerans lipase LipD 0.0072 0.0142 0.032
Onchocerca volvulus 0.0024 0.0023 0.0135
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0015 0.0003 0.0161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0142 0.9444
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0009 0.0567
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.015 1
Echinococcus multilocularis synaptojanin 1 0.0015 0.0003 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0036 0.2356
Echinococcus granulosus smad 0.0025 0.0028 0.0135
Schistosoma mansoni hypothetical protein 0.0147 0.0325 0.162
Schistosoma mansoni ap endonuclease 0.0075 0.015 0.0747
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0058 0.0102
Loa Loa (eye worm) hypothetical protein 0.0072 0.0142 0.0823
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0089 0.0185 0.1071
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0018
Brugia malayi Serine protease Z688.6 precursor 0.0021 0.0016 0.0094
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2005 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0176
Mycobacterium tuberculosis Conserved protein 0.0072 0.0142 0.0357
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0 0.0002
Mycobacterium ulcerans transcriptional regulator 0.1606 0.3894 1
Brugia malayi nuclear receptor NHR-88 0.0024 0.0023 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0328 0.0769 0.3832
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0036 0.2356
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0036 0.2356
Plasmodium vivax vivapain-2 0.0016 0.0006 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0451 0.2247
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0088 0.0509
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0215 0.1068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0088 0.0509
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0003 0.0161
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0009 0.0043
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0036 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.3812
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0088 0.0513
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0023 0.0136
Loa Loa (eye worm) TAR-binding protein 0.0198 0.0451 0.2611
Onchocerca volvulus 0.0106 0.0226 0.1325
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0088 0.0436
Echinococcus granulosus tar DNA binding protein 0.0198 0.0451 0.2247
Loa Loa (eye worm) Smad1 0.0025 0.0028 0.0159
Onchocerca volvulus 0.0106 0.0226 0.1325
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0382 0.0901 0.4493
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0106 0.7048
Brugia malayi Serine protease Z688.6 precursor 0.0021 0.0016 0.0094
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0058
Loa Loa (eye worm) transcription factor SMAD2 0.037 0.087 0.5039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0143 0.084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0088 0.0509
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0009 0.0567
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0088 0.0509
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.003 0.0176
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0509
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0021 0.0016 0.072
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0 0.0002
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0015 0.0003 0.0016
Onchocerca volvulus 0.0016 0.0006 0.0034
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0023 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0094
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Entamoeba histolytica cysteine protease, putative 0.0016 0.0006 0.0118
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0021 0.0016 0.0093
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0023 0.0023
Brugia malayi beta-lactamase family protein 0.0072 0.0142 0.0823
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0025 0.0025
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0051 0.0091 0.0091
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0001 0.0002
Schistosoma mansoni synaptojanin 0.0015 0.0003 0.0013
Brugia malayi G-protein alpha subunit 0.0014 0 0.0002
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0018 0.103
Loa Loa (eye worm) hypothetical protein 0.0072 0.0142 0.0823
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0021 0.0016 0.0079
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.0003 0.0018
Schistosoma mansoni alpha glucosidase 0.0038 0.0059 0.0294
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0059 0.0294
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0059 0.011 0.0547
Brugia malayi cytoplasmic intermediate filament protein 0.0057 0.0105 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0058 0.0337
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0006 0.0036
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0003 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0088 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0088 0.0509
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0185 0.092
Schistosoma mansoni survival motor neuron protein 0.0147 0.0325 0.162
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0003 0.0161
Schistosoma mansoni hypothetical protein 0.0137 0.03 0.1495
Schistosoma mansoni lamin 0.0106 0.0226 0.1126
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0328 0.0769 0.3832
Entamoeba histolytica hypothetical protein 0.0217 0.0498 1
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0021 0.0016 0.1034
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0088 0.0513
Brugia malayi hypothetical protein 0.0024 0.0023 0.0136
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0142 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Brugia malayi conserved hypotetical protein 0.0024 0.0023 0.0136
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0059 0.0346
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0006 0.0371
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0059 0.0343
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0009 0.0562
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0451 0.2247
Loa Loa (eye worm) inositol-1 0.0038 0.0058 0.0335
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0015 0.0003 0.0013
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0009 0.0562
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0023 0.0135
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0059 0.011 0.7303
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.012 0.7938
Entamoeba histolytica hypothetical protein 0.0217 0.0498 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0441
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1606 0.3894 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0175 0.0395 0.1967
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0009 0.0043
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0208
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0036 0.0084
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0006 0.0214
Onchocerca volvulus 0.0016 0.0006 0.0034
Schistosoma mansoni carbon catabolite repressor protein 0.0015 0.0003 0.0013
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0003 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0088 0.0509
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0073 0.0143 0.0713
Onchocerca volvulus 0.0072 0.0142 0.0832
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0142 0.0357
Onchocerca volvulus 0.071 0.1703 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0036 0.0084
Onchocerca volvulus 0.0016 0.0006 0.0034
Echinococcus granulosus FTZ F1 alpha 0.005 0.0088 0.0436
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0023 0.0115
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0121 0.0699
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0023 0.0136
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0018
Brugia malayi follicle stimulating hormone receptor 0.068 0.163 0.9442
Echinococcus multilocularis musashi 0.0106 0.0226 0.0226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0217 0.0498 0.2482
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0029
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0028 0.0135
Echinococcus granulosus tumor protein p63 0.0694 0.1664 0.8301
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0023 0.0115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0034
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Echinococcus multilocularis lamin 0.0106 0.0226 0.0226
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0015 0.0003 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0185 0.092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0088 0.0509
Brugia malayi hypothetical protein 0.0045 0.0076 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0088 0.0436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0088 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Leishmania major hypothetical protein, conserved 0.0075 0.015 1
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0121 0.0699
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0087 0.0502
Schistosoma mansoni smad1 5 8 and 0.0025 0.0028 0.0135
Loa Loa (eye worm) hypothetical protein 0.0106 0.0226 0.1309
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0143 0.0713
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0023 0.0136
Brugia malayi Fli-1 protein 0.0232 0.0534 0.309
Schistosoma mansoni nocturnin 0.0015 0.0003 0.0013
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0175 0.0395 0.1967
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.015 0.8085
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0088 0.0436
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0015 0.0003 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0451 0.2247
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0142 0.0832
Onchocerca volvulus 0.0016 0.0006 0.0034
Onchocerca volvulus 0.0015 0.0003 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.012 0.7938
Echinococcus multilocularis Smad4 0.0025 0.0028 0.0027
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0 0.0002
Brugia malayi hypothetical protein 0.012 0.0258 0.1497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0147 0.0325 0.1883
Loa Loa (eye worm) follicle stimulating hormone receptor 0.068 0.163 0.9442
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0001 0.0002
Echinococcus granulosus survival motor neuron protein 1 0.072 0.1727 0.8612
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0387 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.0093
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0001 0.0006
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0073 0.0143 0.2874
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0089 0.0185 0.092
Onchocerca volvulus 0.0016 0.0006 0.0034
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0021 0.0016 0.1034
Onchocerca volvulus 0.0072 0.0142 0.0832
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0088 0.0436
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0142 0.0275
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0328 0.0769 0.0768
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0015 0.0003 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0088 0.0436
Brugia malayi nuclear receptor NHR-67 0.0024 0.0023 0.0136
Echinococcus multilocularis ubiquitin specific protease 41 0.0073 0.0143 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0328 0.0769 0.3832
Echinococcus granulosus lamin dm0 0.0106 0.0226 0.1126
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0058 0.0286
Schistosoma mansoni gabp alpha 0.0076 0.0153 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0088 0.0509
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0034
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1606 0.3894 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Onchocerca volvulus 0.0024 0.0023 0.0135
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.0387 0.2239
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0003 0.0161
Onchocerca volvulus 0.0029 0.0036 0.0209
Brugia malayi isocitrate dehydrogenase 0.0016 0.0004 0.0024
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0073 0.0143 0.9528
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0217 0.0498 0.0497
Loa Loa (eye worm) hypothetical protein 0.0049 0.0087 0.0502
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0 0.0002
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0016 0.0093
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0009 0.0562
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.012 0.7938
Brugia malayi Intermediate filament tail domain containing protein 0.0106 0.0226 0.1309
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0059 0.011 0.7303
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0015 0.0003 0.0161
Giardia lamblia Thymus-specific serine protease precursor 0.0021 0.0016 0.089
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0382 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0136
Toxoplasma gondii exonuclease III APE 0.0075 0.015 0.8085
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0058 0.0337
Mycobacterium tuberculosis Conserved protein 0.0072 0.0142 0.0357
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0036
Brugia malayi Inositol-1 0.0038 0.0058 0.0335
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0003 0.0016
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0088 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0002
Echinococcus granulosus synaptojanin 1 0.0015 0.0003 0.0013
Schistosoma mansoni smad1 5 8 and 0.0025 0.0028 0.0135
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.0185 0.0184
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0004 0.0024
Mycobacterium ulcerans hypothetical protein 0.0072 0.0142 0.032
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0021 0.0016 0.0317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0034
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0059 0.011 0.7303
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.012 0.7938
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0023 0.0136
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0142 0.0707
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2005 1
Onchocerca volvulus 0.0015 0.0003 0.0016
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0018
Mycobacterium tuberculosis Conserved protein 0.0072 0.0142 0.0357
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0121 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0051
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0009 0.0562
Echinococcus multilocularis geminin 0.0337 0.079 0.0789
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0015 0.0003 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0088 0.0436
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0025 0.0124

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.636 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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