Detailed information for compound 1322706

Basic information

Technical information
  • TDR Targets ID: 1322706
  • Name: N-[(2,3-dimethoxyphenyl)methyl]-2-(1-oxopyrro lo[1,2-d][1,2,4]triazin-2-yl)propanamide
  • MW: 356.376 | Formula: C18H20N4O4
  • H donors: 1 H acceptors: 2 LogP: 1.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(cccc1OC)CNC(=O)C(n1ncn2c(c1=O)ccc2)C
  • InChi: 1S/C18H20N4O4/c1-12(22-18(24)14-7-5-9-21(14)11-20-22)17(23)19-10-13-6-4-8-15(25-2)16(13)26-3/h4-9,11-12H,10H2,1-3H3,(H,19,23)
  • InChiKey: LQMCSSDSLRUFSA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(2,3-dimethoxyphenyl)methyl]-2-(1-oxo-2-pyrrolo[1,2-d][1,2,4]triazinyl)propanamide
  • N-(2,3-dimethoxybenzyl)-2-(1-ketopyrrolo[1,2-d][1,2,4]triazin-2-yl)propionamide
  • E020-1813
  • NCGC00120277-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0138 0.1486 0.2839
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.0137 0.1915
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0148 0.1618 0.3093
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1884 0.6195
Trichomonas vaginalis esterase, putative 0.0036 0.0146 0.0478
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0141 0.1524 0.2912
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0715 0.0715
Onchocerca volvulus 0.0054 0.0381 0.2023
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.0379 0.0725
Brugia malayi Cell death protein 3 precursor 0.0063 0.0506 0.0968
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0146 0.0867
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0715 0.2351
Loa Loa (eye worm) notch protein 0.0054 0.0381 0.0729
Toxoplasma gondii calcium binding egf domain-containing protein 0.0141 0.1524 0.9417
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0454 0.0454
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.0379 0.0725
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0425 0.3787
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1123 0.6834
Echinococcus granulosus delta-like protein 1 0.0054 0.0381 0.0729
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0174 0.0174
Onchocerca volvulus 0.0079 0.0715 0.3795
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.2823 0.5395
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0384 0.0384
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.024 0.0458
Brugia malayi Bromodomain containing protein 0.0038 0.0175 0.0335
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Brugia malayi Cathepsin L-like precursor 0.0079 0.0715 0.1367
Echinococcus granulosus Mastin 0.0043 0.024 0.0458
Brugia malayi 6-phosphofructokinase 0.011 0.1123 0.2146
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1884 0.6195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.029 0.1511
Onchocerca volvulus Arrow homolog 0.0141 0.1524 0.8087
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.024 0.0458
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0043 0.024 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0148 0.1618 0.532
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0146 0.0278
Leishmania major cysteine peptidase A (CPA) 0.0079 0.0715 0.4231
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Onchocerca volvulus 0.0043 0.024 0.1271
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0053 0.0379 0.3052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0262
Loa Loa (eye worm) trypsin family protein 0.0043 0.024 0.0458
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0043 0.024 0.024
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.0379 0.0725
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0715 0.1367
Schistosoma mansoni notch 0.0054 0.0381 0.0729
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0146 0.0867
Echinococcus granulosus cysteine protease 0.0047 0.029 0.0554
Plasmodium vivax vivapain-2 0.0079 0.0715 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0715 0.2351
Echinococcus granulosus transmembrane protease serine 3 0.0043 0.024 0.0458
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0283 0.054
Brugia malayi Cytochrome P450 family protein 0.0048 0.0312 0.0596
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0067 0.0221
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0053 0.0101
Schistosoma mansoni hypothetical protein 0.0138 0.1486 0.2839
Toxoplasma gondii kringle domain-containing protein 0.0035 0.0137 0.0846
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0278
Echinococcus multilocularis Tolloid protein 1 0.0141 0.1524 0.1524
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0715 0.0715
Onchocerca volvulus 0.0043 0.024 0.1271
Brugia malayi Cathepsin L-like precursor 0.0079 0.0715 0.1367
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Schistosoma mansoni survival motor neuron protein 0.0049 0.0318 0.0608
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Giardia lamblia Cathepsin B precursor 0.0148 0.1618 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0174 0.0332
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0174 0.0772
Loa Loa (eye worm) hypothetical protein 0.0141 0.1524 0.2912
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0067 0.0939
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0715 0.1367
Plasmodium vivax vivapain-1 0.0047 0.029 0.4054
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Loa Loa (eye worm) hypothetical protein 0.0141 0.1524 0.2912
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0067 0.0939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.024 0.0458
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0257 0.0492
Echinococcus multilocularis cathepsin L 0.0047 0.029 0.029
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0425 0.0813
Brugia malayi Calcium binding EGF domain containing protein 0.0054 0.0381 0.0729
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0053 0.047
Echinococcus granulosus slit 2 protein 0.0054 0.0381 0.0729
Brugia malayi Fibulin-1 precursor 0.0141 0.1524 0.2912
Loa Loa (eye worm) hypothetical protein 0.0063 0.0506 0.0968
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0138 0.1486 0.1486
Echinococcus multilocularis cysteine protease 0.0079 0.0715 0.0715
Onchocerca volvulus 0.0138 0.1486 0.7884
Echinococcus granulosus tumor protein p63 0.0408 0.5041 0.9635
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0053 0.047
Brugia malayi hypothetical protein 0.0153 0.1687 0.3224
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0174 0.5
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1123 0.2146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Echinococcus multilocularis glycoprotein Antigen 5 0.0043 0.024 0.024
Giardia lamblia Cathepsin B precursor 0.0148 0.1618 1
Leishmania major cathepsin L-like protease 0.0079 0.0715 0.4231
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0138 0.1486 0.2839
Onchocerca volvulus 0.0054 0.0381 0.2023
Loa Loa (eye worm) hypothetical protein 0.0153 0.1687 0.3224
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Loa Loa (eye worm) hypothetical protein 0.0138 0.1486 0.2839
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.029 0.0554
Echinococcus multilocularis cathepsin b 0.0423 0.5232 0.5232
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.029 0.4054
Loa Loa (eye worm) hypothetical protein 0.0042 0.0232 0.0444
Schistosoma mansoni hypothetical protein 0.0054 0.0381 0.0729
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.2003 0.6586
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0079 0.0715 1
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0379 0.2344
Loa Loa (eye worm) hypothetical protein 0.0141 0.1524 0.2912
Plasmodium vivax vivapain-2 0.0079 0.0715 1
Echinococcus granulosus glycoprotein Antigen 5 0.0043 0.024 0.0458
Echinococcus multilocularis snurportin 1 0.0306 0.3701 0.3701
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Schistosoma mansoni ap endonuclease 0.0038 0.0174 0.0332
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0379 0.0725
Brugia malayi Cathepsin L-like precursor 0.0057 0.0425 0.0813
Echinococcus multilocularis cathepsin b 0.0423 0.5232 0.5232
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0174 0.0769
Schistosoma mansoni hypothetical protein 0.0043 0.024 0.0458
Loa Loa (eye worm) cathepsin B 0.0148 0.1618 0.3093
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0146 0.0278
Brugia malayi EGF-like domain containing protein 0.0054 0.0381 0.0729
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0715 0.6369
Brugia malayi 6-phosphofructokinase 0.011 0.1123 0.2146
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0137 0.0137
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0174 0.0571
Schistosoma mansoni importin beta-1 0.0029 0.0053 0.0102
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0715 0.1367
Giardia lamblia Cathepsin B precursor 0.0148 0.1618 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0174 0.0332
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3042 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0067 0.0221
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0425 0.0813
Onchocerca volvulus 0.006 0.0462 0.2449
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1123 0.3691
Loa Loa (eye worm) hypothetical protein 0.0046 0.0283 0.054
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Echinococcus multilocularis neurogenic locus notch protein 4 0.0054 0.0381 0.0381
Mycobacterium ulcerans beta-lactamase 0.0036 0.0146 0.0867
Trypanosoma brucei cysteine peptidase C (CPC) 0.0148 0.1618 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1123 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Loa Loa (eye worm) beta-lactamase 0.0036 0.0146 0.0278
Onchocerca volvulus 0.0036 0.0146 0.0772
Brugia malayi Bromodomain containing protein 0.0074 0.0654 0.1249
Leishmania major cathepsin L-like protease 0.0079 0.0715 0.4231
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0146 0.0478
Brugia malayi beta-lactamase 0.0036 0.0146 0.0278
Brugia malayi Calcium binding EGF domain containing protein 0.0141 0.1524 0.2912
Echinococcus multilocularis fibrillin 1 0.0141 0.1524 0.1524
Loa Loa (eye worm) hypothetical protein 0.006 0.0462 0.0882
Brugia malayi Cathepsin L-like precursor 0.0079 0.0715 0.1367
Trypanosoma cruzi cysteine protease, putative 0.0047 0.029 0.0554
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.3701 0.7074
Plasmodium falciparum cysteine proteinase falcipain 3 0.0079 0.0715 1
Echinococcus multilocularis slit 2 protein 0.0054 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0079 0.0715 0.1367
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0298 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0715 0.2351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Onchocerca volvulus 0.0079 0.0715 0.3795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0425 0.1398
Loa Loa (eye worm) hypothetical protein 0.0047 0.0298 0.0569
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0318 0.0608
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.2226 0.4255
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.2823 0.2823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.024 0.0458
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0715 0.3795
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0257 0.0492
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.029 0.0554
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0053 0.0101
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0148 0.1618 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0141 0.1524 0.2912
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2674 1
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.029 0.0554
Echinococcus multilocularis inhibitor of apoptosis protein 0.0138 0.1486 0.1486
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0067 0.0221
Brugia malayi Trypsin family protein 0.0043 0.024 0.0458
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0379 0.1247
Loa Loa (eye worm) hypothetical protein 0.0043 0.024 0.0458
Echinococcus granulosus neurogenic locus notch protein 0.0054 0.0381 0.0729
Leishmania major fk506-binding protein 1-like protein 0.0053 0.0379 0.2086
Loa Loa (eye worm) Notch2 0.0054 0.0381 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Toxoplasma gondii cathepsin B 0.0148 0.1618 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0063 0.0506 0.0968
Brugia malayi RNA, U transporter 1 0.0082 0.0748 0.1431
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0067 0.5
Loa Loa (eye worm) MBCTL1 0.0054 0.0384 0.0734
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0257 0.0492
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3042 1
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1123 0.3691
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0715 0.1367
Schistosoma mansoni hypothetical protein 0.0173 0.1949 0.3725
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0054 0.0381 0.2023
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0174 0.0332
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0423 0.5232 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0384 0.0734
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Brugia malayi Muscle positioning protein 4 0.0054 0.0381 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0298 0.1581
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.3042 0.5813
Echinococcus granulosus cathepsin l1 0.0079 0.0715 0.1367
Loa Loa (eye worm) hypothetical protein 0.007 0.0598 0.1143
Echinococcus granulosus snurportin 1 0.0306 0.3701 0.7074
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Echinococcus multilocularis enteropeptidase 0.0043 0.024 0.024
Echinococcus granulosus protein jagged 2 0.0054 0.0381 0.0729
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0146 0.0278
Echinococcus multilocularis geminin 0.0173 0.1949 0.1949
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0174 0.113
Leishmania major cathepsin L-like protease 0.0079 0.0715 0.4231
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0715 0.2351
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0138 0.1486 0.2839
Echinococcus granulosus neurogenic locus notch protein 0.0054 0.0381 0.0729
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.029 0.0554
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0102
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.024 0.0458
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0054 0.0381 0.0729
Brugia malayi PHD-finger family protein 0.0025 0.0001 0.0002
Echinococcus multilocularis neurogenic locus protein delta 0.0054 0.0381 0.0381
Schistosoma mansoni inhibitor of apoptosis protein 0.0138 0.1486 0.2839
Trypanosoma cruzi cruzipain precursor, putative 0.0079 0.0715 0.1367
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0257 0.0492
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0141 0.1524 0.2912
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1123 0.2146
Schistosoma mansoni egf-like domain protein 0.0141 0.1524 0.2912
Brugia malayi notch-like transmembrane receptor 0.0054 0.0381 0.0729
Echinococcus multilocularis tumor protein p63 0.0408 0.5041 0.5041
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0715 0.0715
Onchocerca volvulus 0.0049 0.0318 0.1688
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0146 0.0478
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.029 0.0554
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.029 0.2582
Brugia malayi hypothetical protein 0.0043 0.024 0.0458
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0715 0.1367
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0043 0.024 0.0458
Brugia malayi phosphofructokinase 0.011 0.1123 0.2146
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0054 0.0381 0.0729
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0298 0.0569
Onchocerca volvulus 0.0079 0.0715 0.3795
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0145 0.0276
Onchocerca volvulus Deterin homolog 0.0138 0.1486 0.7884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0715 0.2351
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0379 0.2083
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0146 0.0278
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.029 0.2582
Leishmania major cathepsin L-like protease 0.0079 0.0715 0.4231
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0379 0.2083
Onchocerca volvulus 0.0054 0.0381 0.2023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.029 0.0953
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.029 0.0554
Echinococcus multilocularis protein jagged 1 0.0054 0.0381 0.0381
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0379 0.5305
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0148 0.1618 0.3093
Toxoplasma gondii ABC1 family protein 0.0036 0.0146 0.0899
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.3042 0.5813
Brugia malayi mbt repeat family protein 0.0047 0.0298 0.0569
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0053 0.0379 0.3379
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1123 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Echinococcus multilocularis neurogenic locus protein delta 0.0054 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0101
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0174 0.0332
Trichomonas vaginalis immunophilin, putative 0.0053 0.0379 0.1247
Echinococcus granulosus cathepsin b 0.0423 0.5232 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0053 0.0379 0.3379
Toxoplasma gondii exonuclease III APE 0.0038 0.0174 0.1073
Onchocerca volvulus Putative cubilin 0.0054 0.0381 0.2023
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0174 0.1009
Echinococcus multilocularis fibropellin Ia 0.0054 0.0381 0.0381
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0043 0.024 0.0458
Echinococcus granulosus importin subunit beta 1 0.0029 0.0053 0.0102
Toxoplasma gondii cathepsin CPL 0.0079 0.0715 0.4419
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0174 0.1547
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0715 0.0715
Brugia malayi Cadherin domain containing protein 0.0054 0.0381 0.0729
Onchocerca volvulus 0.0043 0.024 0.1271
Schistosoma mansoni hypothetical protein 0.0054 0.0381 0.0729
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0146 0.0354
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1884 0.6195
Loa Loa (eye worm) fibroinase 0.0079 0.0715 0.1367
Schistosoma mansoni hypothetical protein 0.0054 0.0381 0.0729
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0053 0.0379 0.2958
Toxoplasma gondii EGF family domain-containing protein 0.0054 0.0381 0.2356
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1123 0.3691
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0141 0.1524 0.2912
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.029 0.0554
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0298 0.0298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Schistosoma mansoni hypothetical protein 0.0173 0.1949 0.3725
Schistosoma mansoni notch 0.0054 0.0381 0.0729
Brugia malayi Cathepsin L-like precursor 0.0079 0.0715 0.1367
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1884 0.6195
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1123 1
Echinococcus multilocularis laminin 0.0141 0.1524 0.1524
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0067 0.0598
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1123 0.1123
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0141 0.1524 0.2912
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0146 0.0354
Brugia malayi mbt repeat family protein 0.0047 0.0298 0.0569
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0715 0.2351
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.024 0.0458
Schistosoma mansoni septate junction protein 0.0054 0.0381 0.0729
Loa Loa (eye worm) hypothetical protein 0.0043 0.024 0.0458
Loa Loa (eye worm) hypothetical protein 0.0141 0.1524 0.2912
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0146 0.0354
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Leishmania major hypothetical protein, conserved 0.0036 0.0146 0.0593
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0379 0.0379
Onchocerca volvulus Cell death protein 3 homolog 0.0063 0.0506 0.2688
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0715 0.2351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Plasmodium vivax vivapain-3 0.0047 0.029 0.4054
Echinococcus granulosus caspase 2 0.0063 0.0506 0.0968
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0379 0.0725
Onchocerca volvulus 0.0054 0.0381 0.2023
Onchocerca volvulus 0.0035 0.0137 0.0727
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1123 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.029 0.0953
Loa Loa (eye worm) hypothetical protein 0.0043 0.024 0.0458
Schistosoma mansoni hypothetical protein 0.0306 0.3701 0.7074
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.2226 0.2226
Echinococcus multilocularis Mastin 0.0043 0.024 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0715 0.2351
Echinococcus granulosus inhibitor of apoptosis protein 0.0138 0.1486 0.2839
Echinococcus granulosus neural cadherin 0.0054 0.0381 0.0729
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0146 0.0867
Brugia malayi hypothetical protein 0.0063 0.0506 0.0968
Schistosoma mansoni bromodomain containing protein 0.0063 0.0501 0.0957
Loa Loa (eye worm) cysteine protease 0.0079 0.0715 0.1367
Loa Loa (eye worm) hypothetical protein 0.0057 0.0425 0.0813
Onchocerca volvulus 0.0043 0.024 0.1271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.029 0.1511
Onchocerca volvulus 0.0054 0.0381 0.2023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Echinococcus multilocularis neurogenic locus notch protein 0.0054 0.0381 0.0381
Echinococcus multilocularis neurogenic locus notch protein 0.0054 0.0381 0.0381
Echinococcus granulosus cathepsin b 0.0423 0.5232 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0146 0.0278
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Brugia malayi cathepsin B-like cysteine proteinase 0.0423 0.5232 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0063 0.0506 0.0968
Brugia malayi Kringle domain containing protein 0.0035 0.0137 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.029 0.2582
Loa Loa (eye worm) hypothetical protein 0.0057 0.0425 0.0813
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0146 0.0354
Schistosoma mansoni notch 0.0054 0.0381 0.0729
Echinococcus multilocularis transmembrane protease serine 3 0.0043 0.024 0.024
Brugia malayi hypothetical protein 0.0239 0.2823 0.5395
Echinococcus multilocularis apoptotic protease activating factor 1 0.0063 0.0506 0.0506
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3042 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0145 0.0145
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0079 0.0715 0.1367
Echinococcus granulosus cathepsin l cysteine peptidase 0.0079 0.0715 0.1367
Echinococcus granulosus enteropeptidase 0.0043 0.024 0.0458
Schistosoma mansoni hypothetical protein 0.0035 0.0137 0.0262
Onchocerca volvulus 0.0079 0.0715 0.3795
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Brugia malayi EGF-like domain containing protein 0.0054 0.0381 0.0729
Loa Loa (eye worm) hypothetical protein 0.0043 0.024 0.0458
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0379 0.0725
Brugia malayi EGF-like domain containing protein 0.0054 0.0381 0.0729
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1123 0.4082
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0079 0.0715 1
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.0379 0.1247
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1123 0.2146
Echinococcus granulosus cathepsin l1 0.0057 0.0425 0.0813
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0257 0.0492
Schistosoma mansoni notch 0.0054 0.0381 0.0729
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3042 1
Brugia malayi beta-lactamase family protein 0.0036 0.0146 0.0278
Leishmania major cathepsin L-like protease 0.0079 0.0715 0.4231
Echinococcus granulosus protein jagged 1 0.0054 0.0381 0.0729
Onchocerca volvulus 0.0079 0.0715 0.3795
Brugia malayi Trypsin-like protease protein 5 0.0043 0.024 0.0458
Loa Loa (eye worm) hypothetical protein 0.0057 0.0425 0.0813
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0384 0.0734
Mycobacterium tuberculosis Conserved protein 0.0036 0.0146 0.0354
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0174 0.1073
Echinococcus granulosus geminin 0.0173 0.1949 0.3725
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0146 0.0478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Echinococcus multilocularis fat cadherin tumor suppressor 0.0054 0.0381 0.0381
Schistosoma mansoni notch 0.0054 0.0381 0.0729
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1123 1
Brugia malayi Trypsin family protein 0.0043 0.024 0.0458
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0715 0.1367
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Leishmania major cathepsin L-like protease 0.0079 0.0715 0.4231
Echinococcus multilocularis cysteine protease 0.0079 0.0715 0.0715
Echinococcus multilocularis caspase 2 0.0063 0.0506 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0425 0.1398
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0067 0.0415
Brugia malayi Cadherin domain containing protein 0.0054 0.0381 0.0729
Brugia malayi Delta serrate ligand family protein 0.0054 0.0381 0.0729
Echinococcus multilocularis protein jagged 1 0.0054 0.0381 0.0381
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0137 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0423 0.5232 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0174 0.0571
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.029 0.0554
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0278
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0423 0.5232 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0462 0.0882
Loa Loa (eye worm) ctsf protein 0.0079 0.0715 0.1367
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0715 0.1367
Echinococcus granulosus Tolloid protein 1 0.0141 0.1524 0.2912
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.0379 0.0725
Schistosoma mansoni cell polarity protein 0.0054 0.0381 0.0729
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1123 0.2146
Schistosoma mansoni hypothetical protein 0.0054 0.0381 0.0729
Plasmodium vivax importin-beta 2, putative 0.0029 0.0053 0.0746
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0067 0.0221
Echinococcus granulosus laminin 0.0141 0.1524 0.2912
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0312 0.0596
Brugia malayi EGF-like domain containing protein 0.0054 0.0381 0.0729
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0053 0.0101
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0067 0.0415
Schistosoma mansoni laminin gamma-3 chain 0.0054 0.0381 0.0729
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0053 0.0379 0.5305
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 0.5232 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0067 0.0221
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0146 0.0354
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.029 0.2582
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0067 0.0221
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0298 0.0569
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0146 0.0478
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0715 0.6369
Plasmodium falciparum importin beta, putative 0.0029 0.0053 0.0746
Loa Loa (eye worm) hypothetical protein 0.0239 0.2823 0.5395
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.0379 0.0725
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0257 0.0257
Onchocerca volvulus 0.0153 0.1687 0.8953
Brugia malayi Cathepsin L-like precursor 0.0057 0.0425 0.0813
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0298 0.0569
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0067 0.0415
Toxoplasma gondii calcium binding egf domain-containing protein 0.0141 0.1524 0.9417
Echinococcus granulosus neurogenic locus protein delta 0.0054 0.0381 0.0729
Onchocerca volvulus 0.0057 0.0425 0.2256
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0379 0.0725
Loa Loa (eye worm) hypothetical protein 0.0043 0.024 0.0458
Schistosoma mansoni slit 0.0054 0.0381 0.0729
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.029 0.0554
Echinococcus multilocularis protein jagged 2 0.0054 0.0381 0.0381
Mycobacterium ulcerans hypothetical protein 0.0043 0.024 0.1746
Loa Loa (eye worm) hypothetical protein 0.0043 0.024 0.0458
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Loa Loa (eye worm) phosphofructokinase 0.011 0.1123 0.2146
Leishmania major peptidylprolyl isomerase-like protein 0.0053 0.0379 0.2086
Mycobacterium tuberculosis Conserved protein 0.0036 0.0146 0.0354
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0257 0.0257
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0053 0.047
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0146 0.2035
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0298 0.0298
Schistosoma mansoni notch 0.0054 0.0381 0.0729
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0278
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Brugia malayi cathepsin L-like precursor 0.0057 0.0425 0.0813
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0278
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Brugia malayi Trypsin family protein 0.0043 0.024 0.0458
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0379 0.1247
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0278
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Leishmania major hypothetical protein, conserved 0.0035 0.0137 0.0538
Schistosoma mansoni hypothetical protein 0.0054 0.0381 0.0729
Mycobacterium tuberculosis Conserved protein 0.0036 0.0146 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0454 0.0868
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0174 0.2428
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Brugia malayi beta-lactamase family protein 0.0036 0.0146 0.0278
Giardia lamblia High cysteine protein 0.0054 0.0381 0.2356
Schistosoma mansoni hypothetical protein 0.0054 0.0381 0.0729
Onchocerca volvulus 0.0079 0.0715 0.3795
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0146 0.0278
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0715 0.3795
Onchocerca volvulus 0.0029 0.0053 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.0262
Onchocerca volvulus 0.0036 0.0146 0.0772
Schistosoma mansoni hypothetical protein 0.0295 0.3555 0.6795
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0146 0.0354
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Brugia malayi Protein kinase domain containing protein 0.0035 0.0137 0.0262
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1123 0.3691
Echinococcus granulosus cathepsin L 0.0047 0.029 0.0554
Mycobacterium ulcerans lipase LipD 0.0036 0.0146 0.0867
Echinococcus multilocularis notch 0.0054 0.0381 0.0381
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1123 0.2146
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1884 0.6195
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3042 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.029 0.2582
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 0.5232 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0067 0.5
Onchocerca volvulus 0.0036 0.0146 0.0772
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0715 0.2351
Onchocerca volvulus 0.0079 0.0715 0.3795
Schistosoma mansoni caspase-7 (C14 family) 0.0063 0.0506 0.0968
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0067 0.0221
Echinococcus granulosus protein jagged 1 0.0054 0.0381 0.0729
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0101
Schistosoma mansoni immunophilin 0.0046 0.0283 0.054
Leishmania major cathepsin L-like protease 0.0079 0.0715 0.4231
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0379 0.0725
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0146 0.0278
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.0137 0.1915
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0283 0.0283
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Brugia malayi EGF-like domain containing protein 0.0054 0.0381 0.0729
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1123 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0043 0.024 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0715 0.2351
Brugia malayi Trypsin family protein 0.0043 0.024 0.0458
Brugia malayi Cathepsin L-like precursor 0.0079 0.0715 0.1367
Schistosoma mansoni hypothetical protein 0.0043 0.024 0.0458
Loa Loa (eye worm) hypothetical protein 0.0038 0.0176 0.0337
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0043 0.024 0.0458
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1884 0.6195
Echinococcus granulosus neurogenic locus notch protein 4 0.0054 0.0381 0.0729
Loa Loa (eye worm) hypothetical protein 0.0138 0.1486 0.2839
Brugia malayi EGF-like domain containing protein 0.0054 0.0381 0.0729
Onchocerca volvulus 0.0063 0.0506 0.2688
Echinococcus granulosus cathepsin L cysteine proteinase 0.0079 0.0715 0.1367
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.024 0.0458
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0715 0.2351
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0384 0.0384
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0257 0.0492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0715 0.4229
Onchocerca volvulus Neurogenic locus notch homolog 0.0054 0.0381 0.2023
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0174 0.0332
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0715 0.1367
Onchocerca volvulus 0.0043 0.024 0.1271
Schistosoma mansoni immunophilin 0.0053 0.0379 0.0725
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0298 0.0569
Schistosoma mansoni ap endonuclease 0.0038 0.0174 0.0332
Brugia malayi Cathepsin L-like precursor 0.0079 0.0715 0.1367
Brugia malayi GCC2 and GCC3 family protein 0.0054 0.0381 0.0729
Leishmania major cathepsin L-like protease 0.0079 0.0715 0.4231
Entamoeba histolytica cysteine protease, putative 0.0079 0.0715 0.6369
Loa Loa (eye worm) hypothetical protein 0.0141 0.1524 0.2912
Mycobacterium leprae Probable lipase LipE 0.0036 0.0146 0.0867
Schistosoma mansoni immunophilin 0.0053 0.0379 0.0725
Brugia malayi Calcium binding EGF domain containing protein 0.0054 0.0381 0.0729
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0298 0.0569
Echinococcus multilocularis fk506 binding protein 0.0053 0.0379 0.0379
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0146 0.0478
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0278
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0174 0.2428
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0053 0.0379 0.2344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Schistosoma mansoni hypothetical protein 0.0049 0.0318 0.0608
Schistosoma mansoni hypothetical protein 0.0063 0.0506 0.0968
Schistosoma mansoni hypothetical protein 0.0054 0.0381 0.0729
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0384 0.0734
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3042 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1123 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0146 0.0867
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0067 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1884 0.6195
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.0425 0.0813
Echinococcus granulosus fibropellin Ia 0.0054 0.0381 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 0.5232 1
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0138 0.1486 0.2839
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0146 0.0354
Brugia malayi EGF-like domain containing protein 0.0054 0.0381 0.0729
Echinococcus granulosus protein jagged 2 0.0054 0.0381 0.0729
Entamoeba histolytica cysteine protease, putative 0.0047 0.029 0.2582
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0053 0.033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0715 0.2351
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0067 0.0939
Onchocerca volvulus 0.0047 0.0298 0.1581
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0174 0.0461
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.029 0.0554
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.2003 0.6586
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0067 0.0939
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.024 0.0458
Loa Loa (eye worm) hypothetical protein 0.0043 0.024 0.0458
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0137 0.0262
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0257 0.0492
Echinococcus granulosus notch 0.0054 0.0381 0.0729
Loa Loa (eye worm) FKBP5 protein 0.0053 0.0379 0.0725
Onchocerca volvulus Cathepsin F homolog 0.0079 0.0715 0.3795
Plasmodium vivax unspecified product 0.0047 0.029 0.4054
Echinococcus multilocularis neural cadherin 0.0054 0.0381 0.0381
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0384 0.0734
Onchocerca volvulus Slit protein homolog 0.0054 0.0381 0.2023
Onchocerca volvulus 0.0043 0.024 0.1271
Brugia malayi Calcium binding EGF domain containing protein 0.0054 0.0381 0.0729
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1884 1
Entamoeba histolytica cysteine proteinase 2 0.0047 0.029 0.2582
Loa Loa (eye worm) hypothetical protein 0.0054 0.0384 0.0734
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0729
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0146 0.0589
Brugia malayi Importin beta-1 subunit 0.0029 0.0053 0.0102
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1123 0.6835

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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