Detailed information for compound 1336294

Basic information

Technical information
  • TDR Targets ID: 1336294
  • Name: ethyl (Z)-2-cyano-3-(2-ethoxy-1-ethylindol-3- yl)prop-2-enoate
  • MW: 312.363 | Formula: C18H20N2O3
  • H donors: 0 H acceptors: 2 LogP: 3.55 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)/C(=C\c1c(OCC)n(c2c1cccc2)CC)/C#N
  • InChi: 1S/C18H20N2O3/c1-4-20-16-10-8-7-9-14(16)15(17(20)22-5-2)11-13(12-19)18(21)23-6-3/h7-11H,4-6H2,1-3H3/b13-11-
  • InChiKey: OHGSVGPEOIZQDE-QBFSEMIESA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl (Z)-2-cyano-3-(2-ethoxy-1-ethyl-indol-3-yl)prop-2-enoate
  • (Z)-2-cyano-3-(2-ethoxy-1-ethyl-3-indolyl)prop-2-enoic acid ethyl ester
  • (Z)-2-cyano-3-(2-ethoxy-1-ethyl-indol-3-yl)acrylic acid ethyl ester
  • STOCK1S-37585
  • (Z)-2-Cyano-3-(2-ethoxy-1-ethyl-1H-indol-3-yl)-acrylic acid ethyl ester
  • MLS000588957
  • SMR000212593

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0205 0.2037 0.2037
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0011 0.004 0.0093
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0011 0.004 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0081 0.0096
Onchocerca volvulus 0.0072 0.0669 0.2245
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0074
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0081 0.0081
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0128 0.035
Onchocerca volvulus 0.0015 0.0081 0.0176
Giardia lamblia Phosphatidylinositol 4-kinase 0.0011 0.004 0.0692
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0926 0.0926
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0055 0.0494 0.1337
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0926 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0249 0.081
Brugia malayi Carboxylesterase family protein 0.0011 0.0046 0.0126
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0475 0.0559
Brugia malayi PHD-finger family protein 0.0024 0.0184 0.0503
Schistosoma mansoni zinc finger protein 0.0015 0.0086 0.0102
Echinococcus granulosus tar DNA binding protein 0.0076 0.0718 0.0845
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0669 0.0787
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0015 0.0081 0.0081
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0046 0.01
Brugia malayi AKH receptor 0.0015 0.0081 0.0223
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0055 0.0494 0.1337
Plasmodium vivax hypothetical protein, conserved 0.0011 0.004 0.0509
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.004 0.011
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.004 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0074
Schistosoma mansoni ferritin 0.0008 0.0018 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0407 0.0407
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0031 0.0000038564
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.016 0.016
Brugia malayi G-protein coupled receptor 0.0015 0.0081 0.0223
Onchocerca volvulus 0.0015 0.0081 0.0176
Schistosoma mansoni acetylcholinesterase 0.0011 0.0046 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0686 0.0807
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0081 0.0096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0407 0.1114
Schistosoma mansoni intermediate filament proteins 0.0033 0.0267 0.0314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0081 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0285 0.0937
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0031 0.0048
Trypanosoma brucei unspecified product 0.0023 0.0172 0.0453
Schistosoma mansoni hypothetical protein 0.004 0.0343 0.0404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0081 0.0096
Echinococcus multilocularis sex peptide receptor 0.0015 0.0081 0.0081
Echinococcus granulosus intermediate filament protein 0.0033 0.0267 0.0314
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Echinococcus granulosus dna polymerase kappa 0.0023 0.0172 0.0202
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0081 0.0223
Schistosoma mansoni tyrosine kinase 0.0202 0.2007 0.2361
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0011 0.004 0.0047
Echinococcus multilocularis serotonin receptor 0.0015 0.0081 0.0081
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.004 0.011
Brugia malayi Smad1 0.0008 0.0014 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0141 0.0431
Leishmania major phosphatidylinositol kinase, putative 0.0011 0.004 0.0093
Loa Loa (eye worm) hypothetical protein 0.0421 0.4264 1
Onchocerca volvulus 0.0015 0.0081 0.0176
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0669 0.1411
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0359 0.1195
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.004 0.0097
Brugia malayi Carboxylesterase family protein 0.0011 0.0046 0.0126
Brugia malayi G-protein coupled receptor 0.0015 0.0081 0.0223
Loa Loa (eye worm) beta-lactamase 0.0072 0.0669 0.157
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0014 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0407 0.0479
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.004 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0081 0.0223
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0172 0.0453
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0081 0.0223
Echinococcus multilocularis expressed protein 0.0008 0.0018 0.0018
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.016 0.0188
Echinococcus granulosus nibrin 0.001 0.0031 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0081 0.0081
Brugia malayi RE15519p 0.0015 0.0081 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Leishmania major phosphatidylinositol kinase related protein, putative 0.0011 0.004 0.0093
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.004 0.0047
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0128 0.035
Loa Loa (eye worm) hypothetical protein 0.0072 0.0669 0.157
Schistosoma mansoni amine GPCR 0.0015 0.0081 0.0096
Leishmania major DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Echinococcus granulosus replication factor c subunit 1 0.001 0.0031 0.0037
Echinococcus granulosus neuropeptide FF receptor 2 0.0015 0.0081 0.0096
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.004 0.0094
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0018 0.0071
Brugia malayi larval opioid receptor 0.0015 0.0081 0.0223
Echinococcus multilocularis zinc finger protein 0.0019 0.013 0.013
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0205
Echinococcus multilocularis nibrin 0.001 0.0031 0.0031
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0081 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0081 0.0096
Echinococcus granulosus sex peptide receptor 0.0015 0.0081 0.0096
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0669 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Schistosoma mansoni topbp1 0.001 0.0031 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Loa Loa (eye worm) hypothetical protein 0.0286 0.2868 0.6726
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0289 0.034
Schistosoma mansoni Smad4 0.0008 0.0014 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0172 0.1048
Loa Loa (eye worm) hypothetical protein 0.0053 0.0475 0.1114
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0031 0.0048
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0031 0.0069
Schistosoma mansoni fkbp-rapamycin associated protein 0.0031 0.0249 0.0293
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0031 1
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0081 0.0081
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0015 0.0081 0.0191
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0011 0.004 0.0093
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.1208 0.331
Echinococcus granulosus peptide allatostatin:somatostatin 0.0015 0.0081 0.0096
Brugia malayi Dopamine receptor protein 2 0.0015 0.0081 0.0223
Trypanosoma brucei C-8 sterol isomerase, putative 0.0362 0.3651 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0172 0.0539
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Schistosoma mansoni growth hormone secretagogue receptor 0.0015 0.0081 0.0096
Chlamydia trachomatis DNA ligase 0.001 0.0031 0.5
Loa Loa (eye worm) PHD-finger family protein 0.002 0.014 0.0329
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0081 0.0223
Toxoplasma gondii FATC domain-containing protein 0.0031 0.0249 0.3569
Loa Loa (eye worm) carboxylesterase 0.0011 0.0046 0.0108
Trichomonas vaginalis esterase, putative 0.0072 0.0669 0.2283
Leishmania major hypothetical protein, conserved 0.0015 0.0086 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0249 0.081
Echinococcus granulosus dna polymerase eta 0.0054 0.0488 0.0574
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.85 0.85
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0359 0.0422
Schistosoma mansoni amine GPCR 0.0015 0.0081 0.0096
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0011 0.004 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0074
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0359 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0303 0.0356
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0081 0.0096
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0034 0.0285 0.4101
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0081 0.0096
Loa Loa (eye worm) Smad1 0.0008 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0108
Echinococcus granulosus dro:myosuppressin receptor 0.0015 0.0081 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0046 0.0054
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0015 0.0081 0.0096
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0081 0.0081
Schistosoma mansoni opsin-like receptor 0.0015 0.0081 0.0096
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0031 0.0249 0.0665
Loa Loa (eye worm) hypothetical protein 0.0041 0.0355 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Schistosoma mansoni DNA polymerase eta 0.0054 0.0488 0.0574
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0015 0.0081 0.0096
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0172 0.0172
Echinococcus multilocularis neuropeptide FF receptor 2 0.0015 0.0081 0.0081
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0046 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0081 0.0096
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0531 0.1454
Brugia malayi polk-prov protein 0.0007 0.0006 0.0017
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0104 0.0123
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Brugia malayi Pre-SET motif family protein 0.0036 0.0303 0.0829
Loa Loa (eye worm) hypothetical protein 0.0016 0.0094 0.0219
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0074
Loa Loa (eye worm) melatonin receptor type 1A 0.0015 0.0081 0.0191
Onchocerca volvulus 0.0015 0.0081 0.0176
Loa Loa (eye worm) hypothetical protein 0.0066 0.0608 0.1426
Schistosoma mansoni smad1 5 8 and 0.0008 0.0014 0.0017
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0011 0.004 0.0047
Echinococcus multilocularis neuropeptide s receptor 0.057 0.5793 0.5793
Onchocerca volvulus 0.0015 0.0081 0.0176
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0081 0.0081
Brugia malayi hypothetical protein 0.0286 0.2868 0.7854
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0551 0.1509
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.004 0.0097
Onchocerca volvulus 0.0072 0.0669 0.2245
Plasmodium vivax SET domain protein, putative 0.0036 0.0303 0.4468
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0011 0.004 0.0047
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0081 0.0081
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0081 0.0081
Brugia malayi ORL1-like opioid receptor 0.0015 0.0081 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0031 0.0048
Echinococcus granulosus neuropeptide receptor 0.0015 0.0081 0.0096
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0015 0.0081 0.0096
Schistosoma mansoni smad1 5 8 and 0.0008 0.0014 0.0017
Schistosoma mansoni apoferritin-2 0.0008 0.0018 0.0021
Echinococcus multilocularis musashi 0.0033 0.0267 0.0267
Brugia malayi MH1 domain containing protein 0.0008 0.0014 0.0039
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0718 0.0845
Echinococcus granulosus acetylcholinesterase 0.0066 0.0608 0.0715
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.004 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0081 0.0096
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0784 0.7996 0.9408
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0014 0.0014
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0015 0.0081 0.0081
Echinococcus multilocularis orexin receptor type 2 0.0015 0.0081 0.0081
Onchocerca volvulus Neuropeptide F receptor homolog 0.0015 0.0081 0.0176
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0415
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0475 0.0559
Echinococcus granulosus tachykinin peptides receptor 99D 0.0015 0.0081 0.0096
Echinococcus multilocularis serotonin receptor 0.0015 0.0081 0.0081
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0011 0.004 0.0509
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.004 0.0094
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.011 0.0259
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0267 0.0731
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0081 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0055 0.0494 0.1337
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Echinococcus multilocularis protein dispatched 1 0.0047 0.0419 0.0419
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.004 0.0079
Trypanosoma cruzi target of rapamycin kinase 3 0.0055 0.0494 0.1337
Schistosoma mansoni lamin 0.0033 0.0267 0.0314
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0011 0.004 0.0097
Onchocerca volvulus 0.0015 0.0081 0.0176
Echinococcus granulosus neuropeptide s receptor 0.057 0.5793 0.6816
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0172 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0097 0.0249
Brugia malayi G protein-coupled receptor 0.0015 0.0081 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.004 0.0079
Loa Loa (eye worm) hypothetical protein 0.0031 0.0249 0.0584
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0097 0.0249
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.004 0.0093
Echinococcus granulosus orexin receptor type 2 0.0015 0.0081 0.0096
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0018 0.0071
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0046 0.0065
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0081 0.0081
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0608 0.0608
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0081 0.0081
Echinococcus multilocularis tyrosine protein kinase Abl 0.0083 0.079 0.079
Onchocerca volvulus 0.0036 0.0303 0.0954
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.004 0.0079
Schistosoma mansoni hypothetical protein 0.0019 0.0128 0.015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Onchocerca volvulus 0.0011 0.0046 0.0052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0081 0.0223
Onchocerca volvulus 0.0072 0.0669 0.2245
Brugia malayi MH1 domain containing protein 0.0008 0.0014 0.0039
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0018 0.0003
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0608 0.0715
Loa Loa (eye worm) hypothetical protein 0.0421 0.4264 1
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0018 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0081 0.0096
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0718 0.1685
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0031 0.0048
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0046 0.0054
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0011 0.004 0.0093
Brugia malayi Tyrosine-protein kinase abl-1 0.0083 0.079 0.2164
Loa Loa (eye worm) hypothetical protein 0.0066 0.0608 0.1426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0081 0.0081
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0011 0.004 0.0692
Echinococcus granulosus expressed conserved protein 0.0091 0.0866 0.1019
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1353 0.1353
Schistosoma mansoni adenoreceptor 0.0015 0.0081 0.0096
Leishmania major hypothetical protein, unknown function 0.0011 0.004 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0081 0.0096
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0172 0.0336
Loa Loa (eye worm) phosphatidylinositol kinase 0.0011 0.004 0.0094
Schistosoma mansoni hypothetical protein 0.004 0.0343 0.0404
Entamoeba histolytica protein kinase rad3, putative 0.0031 0.0249 0.2429
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0097 0.0249
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0081 0.0081
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0686 1
Echinococcus granulosus g protein coupled receptor 0.0015 0.0081 0.0096
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0669 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0172 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.004 0.0079
Brugia malayi MH2 domain containing protein 0.0008 0.0014 0.0039
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0011 0.004 0.0079
Echinococcus multilocularis dro:myosuppressin receptor 0.0015 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0303 0.0303
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0015 0.0081 0.0081
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0362 0.3651 1
Brugia malayi topoisomerase 0.001 0.0031 0.0086
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.004 0.0079
Echinococcus multilocularis somatostatin receptor 0.0015 0.0081 0.0081
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0108
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.016 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0475 0.0559
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Echinococcus granulosus GPCR family 2 0.0019 0.0128 0.015
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0081 0.0191
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0015 0.0081 0.0081
Echinococcus granulosus smad 0.0008 0.0014 0.0017
Echinococcus multilocularis serine protein kinase ATM 0.0031 0.0249 0.0249
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0031 0.0048
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0011 0.004 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Brugia malayi hypothetical protein 0.0035 0.0295 0.0809
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0295 0.0347
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0081 0.0096
Loa Loa (eye worm) TK/ABL protein kinase 0.0205 0.2037 0.4778
Trypanosoma brucei ISWI complex protein 0.0015 0.0086 0.022
Onchocerca volvulus 0.0015 0.0081 0.0176
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0081 0.0081
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0031 0.0069
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0015 0.0081 0.0096
Echinococcus granulosus Smad4 0.0008 0.0014 0.0017
Mycobacterium tuberculosis Conserved protein 0.0072 0.0669 0.1411
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0016 0.0063
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0046 0.0065
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0669 1
Schistosoma mansoni ferritin 0.0008 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0362 0.3651 0.8564
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0494 0.1158
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0355 0.0972
Echinococcus granulosus serine protein kinase ATM 0.0031 0.0249 0.0293
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0172 0.0202
Schistosoma mansoni gliotactin 0.0011 0.0046 0.0054
Echinococcus granulosus ferritin 0.0008 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Loa Loa (eye worm) hypothetical protein 0.0038 0.032 0.0749
Schistosoma mansoni hypothetical protein 0.0011 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0669 0.157
Brugia malayi MH2 domain containing protein 0.0117 0.1138 0.3116
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0128 0.0128
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0011 0.004 0.0079
Echinococcus granulosus neuroligin 0.0011 0.0046 0.0054
Schistosoma mansoni hypothetical protein 0.0019 0.0128 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0407 0.0479
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1138 0.2669
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Echinococcus granulosus g protein coupled receptor 0.0015 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0011 0.004 0.0093
Loa Loa (eye worm) carboxylesterase 0.0066 0.0608 0.1426
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0841
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0669 0.2283
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0108
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0718 0.1685
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0081 0.0096
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0015 0.0081 0.0176
Schistosoma mansoni patched 1 0.0042 0.0359 0.0422
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0018 0.0003
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0055 0.0494 0.0581
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0031 0.0048
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.004 0.0047
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0669 0.1411
Loa Loa (eye worm) hypothetical protein 0.0054 0.0488 0.1144
Entamoeba histolytica hypothetical protein 0.0035 0.0295 0.2949
Echinococcus multilocularis protein patched 0.0042 0.0359 0.0359
Leishmania major DNA polymerase eta, putative 0.0038 0.0323 0.0868
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Onchocerca volvulus 0.0011 0.0046 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0081 0.0081
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0081 0.0096
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0686 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0249 0.081
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0128 0.015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0267 0.0626
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0031 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0249 0.081
Giardia lamblia Hypothetical protein 0.0011 0.004 0.0692
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.03
Brugia malayi beta-lactamase 0.0072 0.0669 0.1833
Schistosoma mansoni hypothetical protein 0.0015 0.0086 0.0102
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0784 0.7996 0.7996
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.004 0.0094
Schistosoma mansoni biogenic amine receptor 0.0015 0.0081 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0141 0.0431
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0669 0.2283
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0108
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0031 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0718 0.0845
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0015 0.0081 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0669 0.2283
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0686 0.431
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0323 0.4654
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0669 0.1411
Entamoeba histolytica hypothetical protein 0.0011 0.004 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0407 0.0479
Echinococcus granulosus lamin dm0 0.0033 0.0267 0.0314
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Entamoeba histolytica hypothetical protein 0.0031 0.0249 0.2429
Schistosoma mansoni hypothetical protein 0.002 0.014 0.0165
Echinococcus multilocularis GPCR, family 2 0.0019 0.0128 0.0128
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0011 0.004 0.0093
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0024 0.0177 0.0208
Schistosoma mansoni lamin 0.0033 0.0267 0.0314
Echinococcus multilocularis neuroligin 0.0011 0.0046 0.0046
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0686 0.0807
Echinococcus multilocularis lamin 0.0033 0.0267 0.0267
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0055 0.0494 0.1337
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0031 0.0069
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0046 0.0054
Echinococcus multilocularis G-protein coupled receptor, putative 0.0015 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0024 0.0177 0.0208
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0081 0.0096
Toxoplasma gondii target of rapamycin (TOR), putative 0.0055 0.0494 0.7174
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0011 0.004 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0669 0.1819
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0015 0.0081 0.0191
Onchocerca volvulus 0.0015 0.0081 0.0176
Schistosoma mansoni bromodomain containing protein 0.0062 0.0571 0.0672
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Schistosoma mansoni survival motor neuron protein 0.0058 0.0531 0.0624
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0015 0.0081 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0407 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Echinococcus multilocularis 0.0011 0.004 0.004
Leishmania major C-8 sterol isomerase-like protein 0.0362 0.3651 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0011 0.004 0.0079
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0055 0.0494 0.1337
Echinococcus granulosus zinc finger protein 0.0019 0.013 0.0153
Onchocerca volvulus 0.0286 0.2873 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0055 0.0494 0.1337
Schistosoma mansoni ferritin 0.0008 0.0018 0.0021
Schistosoma mansoni ferritin light chain 0.0008 0.0018 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.004 0.011
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0011 0.004 0.0093
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0686 0.0807
Echinococcus multilocularis smad 0.0008 0.0014 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0669 0.1411
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2516 0.5901
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0942 0.1108
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0669 0.2283
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.004 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0551 0.1509
Brugia malayi FAT domain containing protein 0.0024 0.0177 0.0484
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0172 0.0172
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Mycobacterium ulcerans hypothetical protein 0.0072 0.0669 0.4205
Loa Loa (eye worm) hypothetical protein 0.004 0.0343 0.0805
Schistosoma mansoni biogenic amine receptor 0.0015 0.0081 0.0096
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0669 0.1411
Loa Loa (eye worm) hypothetical protein 0.0051 0.0455 0.1066
Mycobacterium tuberculosis Conserved protein 0.0072 0.0669 0.1411
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0015 0.0081 0.0081
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0046 0.0046
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0031 0.0249 0.0293
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0055 0.0494 0.1337
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Leishmania major hypothetical protein, conserved 0.0285 0.2861 0.7831
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0011 0.004 0.0079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0494 0.1352
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.004 0.0509
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0015 0.0081 0.0096
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0011 0.004 0.0692
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0249 0.0681
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0081 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0249 0.081
Echinococcus granulosus hypothetical protein 0.0015 0.0081 0.0096
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0081 0.0096
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0081 0.0223
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0303 0.436
Onchocerca volvulus 0.0011 0.0046 0.0052
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0669 0.4205
Onchocerca volvulus 0.0015 0.0081 0.0176
Echinococcus multilocularis Smad4 0.0008 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0019 0.0128 0.015
Schistosoma mansoni alpha-1 adrenergic receptor 0.0015 0.0081 0.0096
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0172 0.0402
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0669 0.0787
Loa Loa (eye worm) hypothetical protein 0.002 0.0141 0.033
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0031 0.0048
Trypanosoma brucei unspecified product 0.0016 0.0097 0.0249
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0031 0.0159
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0081 0.0096
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0015 0.0081 0.0191
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0081 0.0081
Schistosoma mansoni amine GPCR 0.0015 0.0081 0.0096
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0081 0.0096
Brugia malayi Carboxylesterase family protein 0.0011 0.0046 0.0126
Brugia malayi neuropeptide F receptor 0.0015 0.0081 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0019 0.0128 0.015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0055 0.0494 0.0494
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Brugia malayi Pre-SET motif family protein 0.0251 0.2516 0.689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0015 0.0081 0.0191
Brugia malayi Serotonin receptor 0.0015 0.0081 0.0223
Echinococcus multilocularis Zinc finger, PHD finger 0.0011 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Entamoeba histolytica hypothetical protein 0.0035 0.0295 0.2949
Loa Loa (eye worm) hypothetical protein 0.0185 0.1833 0.4299
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.004 0.0496
Schistosoma mansoni opsin-like receptor 0.0015 0.0081 0.0096
Brugia malayi MH2 domain containing protein 0.0008 0.0014 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.004 0.011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0359 0.0841
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0011 0.004 0.0047
Trypanosoma brucei unspecified product 0.0016 0.0097 0.0249
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0104 0.0104
Onchocerca volvulus 0.0011 0.0046 0.0052
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0011 0.004 0.0093
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.004 0.0079
Entamoeba histolytica hypothetical protein 0.0011 0.004 0.0097
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0686 0.1447
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0015 0.0081 0.0096
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0323 0.0868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0303 0.0356
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0031 0.0249 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0031 0.0048
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0488 0.1336
Echinococcus granulosus serotonin receptor 0.0015 0.0081 0.0096
Onchocerca volvulus 0.0015 0.0081 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0081 0.0096
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.4643 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0011 0.004 0.0093
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0669 0.4205
Brugia malayi Dopamine receptor 0.0015 0.0081 0.0223
Brugia malayi Dopamine receptor protein 1 0.0015 0.0081 0.0223
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0046 0.0054
Entamoeba histolytica hypothetical protein 0.0011 0.004 0.0097
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0686 0.0686
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0031 0.0249 0.0249
Echinococcus multilocularis lamin dm0 0.0033 0.0267 0.0267
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0686 0.431
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0055 0.0494 0.0581
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0669 0.1819
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.004 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0011 0.004 0.0047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0475 0.0475
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0055 0.0494 0.0494
Mycobacterium ulcerans epoxide hydrolase EphA 0.0161 0.1583 1
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0161 0.1583 0.3386
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0015 0.0081 0.0081
Brugia malayi DKFZp564C0469 protein 0.001 0.0031 0.0086
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0011 0.004 0.004
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0055 0.0494 0.0581
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0014 0.0033
Echinococcus granulosus fmrfamide receptor 0.0015 0.0081 0.0096
Entamoeba histolytica hypothetical protein 0.0035 0.0295 0.2949
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0011 0.004 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0407 0.0479
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0551 0.1292
Brugia malayi hypothetical protein 0.001 0.0031 0.0086
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0669 0.0787
Brugia malayi beta-lactamase family protein 0.0072 0.0669 0.1833
Onchocerca volvulus 0.0058 0.0531 0.1757
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2868 0.3374
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0081 0.0223
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0172 0.0453
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0031 0.0031
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0494 0.1158
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0034 0.0285 0.0668
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Loa Loa (eye worm) RNA binding protein 0.0076 0.0718 0.1685
Schistosoma mansoni neuropeptide receptor 0.0015 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Leishmania major DNA polymerase eta, putative 0.0054 0.0488 0.1321
Brugia malayi Carboxylesterase family protein 0.0066 0.0608 0.1665
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0111 0.0261
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0015 0.0081 0.0096
Leishmania major phosphatidylinositol 3-kinase, putative 0.0011 0.004 0.0093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0081 0.0081
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0608 0.1426
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0108
Onchocerca volvulus 0.0011 0.004 0.003
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0011 0.004 0.0509
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0295 0.0347
Brugia malayi TAR-binding protein 0.0076 0.0718 0.1968
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0669 0.2283
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0535 0.0629
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0081 0.0081
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0718 0.1968
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0081 0.0096
Trypanosoma cruzi ISWI complex protein 0.0015 0.0086 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0081 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0274 0.2753 0.7534
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0081 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0718 0.0845
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0081 0.0081
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0011 0.004 0.0093
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0031 0.7437
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1353 0.1592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0034 0.0285 0.0765
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0081 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0718 0.0845
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0046 0.0054
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.004 0.0496
Onchocerca volvulus 0.0015 0.0081 0.0176
Schistosoma mansoni amine GPCR 0.0015 0.0081 0.0096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.004 0.011
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.004 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Echinococcus granulosus microtubule associated protein 2 0.0833 0.85 1
Loa Loa (eye worm) carboxylesterase 0.0011 0.0046 0.0108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0128 0.015
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0046 0.01
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0014 0.0017
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0081 0.0191
Schistosoma mansoni hypothetical protein 0.004 0.0343 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0718 0.0845
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0081 0.0096
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0011 0.004 0.0047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0081 0.0096
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0011 0.004 0.0047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0295 0.0295
Echinococcus multilocularis expressed conserved protein 0.0091 0.0866 0.0866
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0011 0.004 0.0097
Brugia malayi putative neuropeptide receptor 0.0015 0.0081 0.0223
Schistosoma mansoni hypothetical protein 0.004 0.0343 0.0404
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0014 0.0033
Brugia malayi Serotonin receptor 0.0015 0.0081 0.0223
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0015 0.0081 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0285 0.0937
Giardia lamblia GTOR 0.0055 0.0494 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0011 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0072 0.0669 0.157
Schistosoma mansoni hypothetical protein 0.0035 0.0295 0.0347
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0926 0.2537
Toxoplasma gondii ABC1 family protein 0.0072 0.0669 0.9758
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0015 0.0081 0.0096
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0055 0.0494 0.5166
Schistosoma mansoni apoferritin-2 0.0008 0.0018 0.0021
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.004 0.0047
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0608 0.0608
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0055 0.0494 0.1337
Loa Loa (eye worm) hypothetical protein 0.006 0.0551 0.1292
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0172 0.047
Onchocerca volvulus 0.0015 0.0081 0.0176
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0031 0.0069
Echinococcus granulosus G protein coupled receptor 139 0.0015 0.0081 0.0096
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0267 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Brugia malayi GnHR receptor homolog 0.0015 0.0081 0.0223
Treponema pallidum DNA ligase (lig) 0.001 0.0031 1
Schistosoma mansoni neuropeptide receptor 0.0015 0.0081 0.0096
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0172 0.1048
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.004 0.0097
Schistosoma mansoni zinc finger protein 0.0019 0.013 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0094
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0011 0.004 0.0094
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0015 0.0081 0.0081
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0488 0.1321
Loa Loa (eye worm) hypothetical protein 0.0072 0.0669 0.157
Schistosoma mansoni DNA ligase IV 0.001 0.0031 0.0037
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0011 0.004 1
Onchocerca volvulus 0.0015 0.0081 0.0176
Echinococcus granulosus 7TM GPCR rhodopsin 0.0015 0.0081 0.0096
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0031 0.0369
Echinococcus granulosus expressed protein 0.0008 0.0018 0.0021
Mycobacterium leprae conserved hypothetical protein 0.0011 0.004 0.0364
Brugia malayi intermediate filament protein 0.0033 0.0267 0.0731
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0669 0.1411
Echinococcus multilocularis allatostatin A receptor 0.0015 0.0081 0.0081
Brugia malayi Bromodomain containing protein 0.0074 0.069 0.1888
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0055 0.0494 0.1337
Schistosoma mansoni neuropeptide f receptor 76f 0.0015 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0015
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0055 0.0494 0.0581
Brugia malayi hypothetical protein 0.0011 0.0046 0.0126
Loa Loa (eye worm) hypothetical protein 0.0072 0.0669 0.157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Echinococcus granulosus neuropeptide receptor 0.0015 0.0081 0.0096
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0111 0.0305
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0295 0.0295
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0081 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Echinococcus granulosus lamin 0.0033 0.0267 0.0314
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.85 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Schistosoma mansoni biogenic amine receptor 0.0015 0.0081 0.0096
Schistosoma mansoni hypothetical protein 0.0058 0.0531 0.0624
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Brugia malayi RNA binding protein 0.0076 0.0718 0.1968
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0046 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0205
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0249 0.0681
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.004 0.0097
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0031 0.0249 0.0665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0081 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0177 0.0558
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0359 0.0422
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0011 0.004 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Schistosoma mansoni hypothetical protein 0.0041 0.0355 0.0418
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0249 0.081
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0011 0.004 0.004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0072 0.0669 0.157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0249 0.081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0362 0.3651 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0608 0.0715
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0141 0.0369
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0108
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0055 0.0494 0.1337
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0407 0.0479
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0031 0.0069
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0096
Brugia malayi sulfakinin receptor protein 0.0015 0.0081 0.0223
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2868 0.2868
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0172 0.0539
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0011 0.004 0.0093
Onchocerca volvulus 0.0015 0.0081 0.0176
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0172 0.1566
Leishmania major hypothetical protein, conserved 0.0072 0.0669 0.1819
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0494 0.1352
Loa Loa (eye worm) hypothetical protein 0.0069 0.0646 0.1516
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0011 0.004 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0031 0.0369
Onchocerca volvulus 0.0033 0.0267 0.0828
Echinococcus multilocularis ferritin 0.0008 0.0018 0.0018
Echinococcus granulosus 7tm_1 domain containing protein 0.0015 0.0081 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0249 0.081
Echinococcus multilocularis neuropeptide receptor A26 0.057 0.5793 0.5793
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0046 0.0054
Schistosoma mansoni neuropeptide receptor 0.0015 0.0081 0.0096
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0046 0.0046
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.004 0.0079
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0081 0.0191
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2873 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0407 0.0954
Loa Loa (eye worm) hypothetical protein 0.0072 0.0669 0.157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Schistosoma mansoni topbp1 0.001 0.0031 0.0037
Loa Loa (eye worm) TYRA-2 protein 0.0015 0.0081 0.0191
Echinococcus granulosus g protein coupled receptor 0.0015 0.0081 0.0096
Schistosoma mansoni smad 0.0008 0.0014 0.0017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0094 0.011
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0046 0.0054
Schistosoma mansoni ferritin light chain 0.0008 0.0018 0.0021
Giardia lamblia DINP protein human, muc B family 0.0023 0.0172 0.339
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0055 0.0494 0.1337
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.004 0.011
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0926 0.109
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0011 0.004 0.0047
Echinococcus granulosus tyrosine protein kinase ABL1 0.0205 0.2037 0.2397
Echinococcus granulosus somatostatin receptor 0.0015 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0494 0.1668
Brugia malayi CHE-14 protein 0.0042 0.0359 0.0982
Entamoeba histolytica hypothetical protein 0.0035 0.0295 0.2949
Onchocerca volvulus 0.0015 0.0081 0.0176
Mycobacterium tuberculosis Conserved protein 0.0072 0.0669 0.1411
Brugia malayi Carboxylesterase family protein 0.0066 0.0608 0.1665
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0128 0.03
Brugia malayi Carboxylesterase family protein 0.0011 0.0046 0.0126
Leishmania major phosphatidylinositol 3-kinase, putative 0.0055 0.0494 0.1337
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0031 0.0086
Brugia malayi beta-lactamase family protein 0.0072 0.0669 0.1833
Brugia malayi follicle stimulating hormone receptor 0.0015 0.0081 0.0223
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0011 0.004 0.0079
Mycobacterium leprae Probable lipase LipE 0.0072 0.0669 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0031 0.0249 0.0665
Schistosoma mansoni ferritin 0.0008 0.0018 0.0021
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0015 0.0081 0.0191
Giardia lamblia Replication factor C, subunit 1 0.001 0.0031 0.0515
Mycobacterium ulcerans lipase LipD 0.0072 0.0669 0.4205
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0488 0.1321
Loa Loa (eye worm) hypothetical protein 0.0097 0.0926 0.2173
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0011 0.004 0.0093
Echinococcus granulosus g-protein coupled receptor 0.0015 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0078 0.0731 0.1714
Plasmodium vivax hypothetical protein 0.0011 0.004 0.0509
Schistosoma mansoni smad1 5 8 and 0.0008 0.0014 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0669 0.1819
Brugia malayi Bromodomain containing protein 0.0038 0.0319 0.0873
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0015 0.0081 0.0096
Entamoeba histolytica hypothetical protein 0.0011 0.004 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.004 0.0079
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0014 0.0014
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0295 0.0347
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0081 0.0096
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0172 0.0202
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0031 0.0048
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0046 0.0253
Schistosoma mansoni amine GPCR 0.0015 0.0081 0.0096
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0104 0.0123
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0081 0.0096
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.004 0.0094
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0669 0.1833
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0081 0.0096
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.004 0.0079
Loa Loa (eye worm) hypothetical protein 0.0042 0.0363 0.0851
Echinococcus multilocularis g-protein coupled receptor 0.0015 0.0081 0.0081
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0011 0.004 0.0093
Schistosoma mansoni opsin-like receptor 0.0015 0.0081 0.0096
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0024 0.0177 0.0177
Brugia malayi neuropeptide F receptor 0.0015 0.0081 0.0223
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0055 0.0494 0.5166
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0096
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0669 0.1411
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.0626
Echinococcus multilocularis dna polymerase eta 0.0054 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Leishmania major phosphatidylinositol 4-kinase, putative 0.0011 0.004 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1138 0.2669
Schistosoma mansoni myosin xvIII 0.0015 0.0081 0.0096
Schistosoma mansoni histamine h1 receptor 0.0015 0.0081 0.0096
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0128 0.0128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0686 0.431
Onchocerca volvulus 0.0033 0.0267 0.0828
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0031 0.0048
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0011 0.004 0.0097
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0172 0.0453
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0031 0.0378
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0081 0.0096
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0608 0.0608
Onchocerca volvulus 0.0015 0.0081 0.0176
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.004 0.0496
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.004 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0104 0.0123
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0074
Echinococcus multilocularis G protein coupled receptor 139 0.0015 0.0081 0.0081
Echinococcus granulosus alpha 1A adrenergic receptor 0.0015 0.0081 0.0096
Onchocerca volvulus 0.0015 0.0081 0.0176
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0074
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0081 0.0081
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0081 0.0096
Onchocerca volvulus 0.0011 0.004 0.003
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0191
Echinococcus granulosus acetylcholinesterase 0.0066 0.0608 0.0715
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0718 0.0718
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Echinococcus granulosus neuropeptide receptor A26 0.057 0.5793 0.6816
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0055 0.0494 0.1337
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0055 0.0494 0.1337
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0011 0.004 0.0509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0081 0.0081
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0081 0.0096
Trypanosoma cruzi ISWI complex protein 0.0015 0.0086 0.022
Onchocerca volvulus 0.0011 0.0046 0.0052
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0172 0.0453
Brugia malayi hypothetical protein 0.0015 0.0081 0.0223
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0081 0.0223
Mycobacterium ulcerans beta-lactamase 0.0072 0.0669 0.4205
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0172 0.0453
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0031 0.0249 0.2429
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0031 0.0231
Mycobacterium tuberculosis Conserved hypothetical protein 0.0011 0.004 0.0051
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0094 0.0094
Schistosoma mansoni neuropeptide receptor 0.0015 0.0081 0.0096
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.004 0.0047
Echinococcus granulosus allatostatin A receptor 0.0015 0.0081 0.0096
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0081 0.0081
Brugia malayi hypothetical protein 0.001 0.0031 0.0086
Brugia malayi Melatonin receptor type 1A 0.0015 0.0081 0.0223

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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