Detailed information for compound 1359737

Basic information

Technical information
  • TDR Targets ID: 1359737
  • Name: 5-(azepan-1-ylsulfonyl)-N-[(2,4-dichloropheny l)methyl]-2-methoxy-N-methylbenzamide
  • MW: 485.424 | Formula: C22H26Cl2N2O4S
  • H donors: 0 H acceptors: 3 LogP: 4.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C(=O)N(Cc1ccc(cc1Cl)Cl)C)S(=O)(=O)N1CCCCCC1
  • InChi: 1S/C22H26Cl2N2O4S/c1-25(15-16-7-8-17(23)13-20(16)24)22(27)19-14-18(9-10-21(19)30-2)31(28,29)26-11-5-3-4-6-12-26/h7-10,13-14H,3-6,11-12,15H2,1-2H3
  • InChiKey: DORTVBIOHUBQMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(azepan-1-ylsulfonyl)-N-[(2,4-dichlorophenyl)methyl]-2-methoxy-N-methyl-benzamide
  • 5-(1-azepanylsulfonyl)-N-[(2,4-dichlorophenyl)methyl]-2-methoxy-N-methylbenzamide
  • 5-(azepan-1-ylsulfonyl)-N-(2,4-dichlorobenzyl)-2-methoxy-N-methyl-benzamide
  • T5534650

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone receptor 2 No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone binding protein No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus protein kinase c iota type 0.0322 0.2444 0.2423
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0518 0.427 0.4254
Brugia malayi serine/threonine protein kinase 6 0.0166 0.0998 0.1054
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0346 0.2668 0.3182
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0352 0.0404
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0191 0.1231 0.1207
Brugia malayi hypothetical protein 0.0115 0.052 0.0535
Plasmodium falciparum casein kinase 2, alpha subunit 0.0116 0.0529 0.0616
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0245 0.1729 0.205
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0954 0.8326 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0098 0.0359 0.0411
Loa Loa (eye worm) AGC/PKN protein kinase 0.0336 0.2574 0.2783
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0191 0.1231 0.1451
Echinococcus granulosus mitogen activated protein kinase 14 0.0182 0.114 0.1116
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0086 0.0248 0.0278
Echinococcus multilocularis N chimaerin 0.0101 0.0385 0.0432
Loa Loa (eye worm) thyroid receptor interactor 0.0126 0.0624 0.0675
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Leishmania major protein kinase A catalytic subunit isoform 2 0.0086 0.0248 0.0278
Brugia malayi Cam kinase protein 1 0.0117 0.0536 0.0552
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0287 0.2115 0.2094
Schistosoma mansoni tyrosine kinase 0.0284 0.2088 0.2492
Echinococcus granulosus mitogen activated protein kinase 11 0.0182 0.114 0.1116
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0287 0.2124 0.2527
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Trypanosoma cruzi casein kinase II, putative 0.0116 0.0529 0.0616
Brugia malayi probable protein kinase 0.0081 0.0206 0.0195
Trypanosoma brucei Casein kinase II 0.0116 0.0529 0.0616
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0098 0.0359 0.0411
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0223 0.1527 0.1504
Brugia malayi protein kinase C3,putative 0.0172 0.1046 0.1105
Echinococcus multilocularis casein kinase I gamma 0.0242 0.17 0.2016
Brugia malayi intracellular kinase 0.0148 0.0824 0.0865
Loa Loa (eye worm) CAMK/PKD protein kinase 0.017 0.1033 0.1117
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0673 0.5705 0.617
Brugia malayi Cyclin, N-terminal domain containing protein 0.0083 0.0226 0.0216
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0094 0.0323 0.0368
Brugia malayi Variant SH3 domain containing protein 0.0104 0.0418 0.0425
Echinococcus multilocularis protein kinase c epsilon type 0.0231 0.1598 0.1893
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.0418 0.0482
Giardia lamblia Aurora kinase 0.0166 0.0998 0.1181
Brugia malayi P38 map kinase family protein 2 0.0182 0.114 0.1207
Loa Loa (eye worm) hypothetical protein 0.0104 0.0418 0.0453
Brugia malayi Protein kinase domain containing protein 0.0316 0.239 0.2563
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0166 0.0998 0.0974
Entamoeba histolytica protein kinase, putative 0.0183 0.1156 0.1371
Brugia malayi SH2 domain containing protein 0.0115 0.052 0.0535
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0117 0.0536 0.0613
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0954 0.8326 1
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.01 0.0382 0.0439
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0287 0.2124 0.2527
Toxoplasma gondii AGC kinase 0.0086 0.0248 0.0278
Loa Loa (eye worm) casein kinase 0.0201 0.1317 0.1425
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0954 0.8326 0.8321
Brugia malayi phosphoinositide-dependent protein kinase I 0.0095 0.0336 0.0335
Plasmodium vivax tyrosine kinase-like protein, putative 0.0095 0.0331 0.0378
Echinococcus multilocularis rho associated protein kinase 0.0366 0.2859 0.3412
Echinococcus granulosus signal transduction protein lnk realted 0.0062 0.0031 0.0004
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0084 0.0235 0.0262
Echinococcus multilocularis roundabout 2 0.0155 0.0891 0.1041
Brugia malayi protein-tyrosine kinase 0.0246 0.1736 0.1854
Echinococcus multilocularis signal transduction protein lnk realted 0.0062 0.0031 0.0005
Schistosoma mansoni hypothetical protein 0.0205 0.1354 0.1609
Trichomonas vaginalis cyclins, putative 0.0083 0.0226 0.0272
Echinococcus granulosus rho-associated protein kinase 1 0.0366 0.2859 0.2839
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.1571 0.187
Echinococcus multilocularis NCK adaptor protein 0.0106 0.0439 0.0496
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0104 0.0418 0.0483
Entamoeba histolytica protein kinase, putative 0.0141 0.0758 0.0891
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0211 0.1416 0.1393
Schistosoma mansoni cell adhesion molecule 0.0062 0.0027 0.0012
Schistosoma mansoni protein kinase 0.01 0.0383 0.044
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0062 0.0031 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0179 0.1114 0.131
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0086 0.0248 0.0266
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0125 0.0617 0.0667
Loa Loa (eye worm) hypothetical protein 0.0287 0.2115 0.2288
Trichomonas vaginalis STE family protein kinase 0.0156 0.0902 0.1083
Loa Loa (eye worm) hypothetical protein 0.0113 0.0504 0.0545
Brugia malayi protein kinase C II. 0.0231 0.1598 0.1704
Echinococcus granulosus casein kinase I alpha 0.0125 0.0617 0.0592
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1053 0.9246 1
Brugia malayi Protein kinase domain containing protein 0.0191 0.1231 0.1306
Onchocerca volvulus 0.0137 0.0721 0.1337
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0117 0.0536 0.051
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.033 0.0396
Brugia malayi tRNA modification GTPase TrmE family protein 0.0062 0.0031 0.0004
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0179 0.1114 0.132
Echinococcus multilocularis tyrosine protein kinase 0.032 0.2423 0.2887
Loa Loa (eye worm) SH2 domain-containing protein 0.0062 0.0031 0.0033
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0094 0.0323 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0758 0.0891
Onchocerca volvulus 0.0115 0.052 0.0948
Trichomonas vaginalis AGC family protein kinase 0.0337 0.2583 0.3102
Brugia malayi Kinase associated domain 1 family protein 0.0113 0.0506 0.0519
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0097 0.0352 0.0404
Onchocerca volvulus 0.0083 0.0226 0.0379
Echinococcus granulosus growth factor receptor bound protein 2 0.0106 0.0439 0.0413
Echinococcus granulosus cyclin dependent kinase 0.0954 0.8326 0.8321
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.057 0.0589
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0097 0.0352 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0179 0.1114 0.109
Brugia malayi Protein kinase domain containing protein 0.0141 0.0758 0.0793
Brugia malayi SH2 domain containing protein 0.0062 0.0031 0.0004
Loa Loa (eye worm) AGC/PKA protein kinase 0.0086 0.0248 0.0268
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.033 0.0376
Loa Loa (eye worm) hypothetical protein 0.0137 0.0726 0.0786
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Trichomonas vaginalis cyclin B, putative 0.0083 0.0226 0.0272
Plasmodium falciparum casein kinase 1 0.0125 0.0617 0.0722
Echinococcus granulosus tyrosine protein kinase Blk 0.0246 0.1736 0.1714
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0359 0.0431
Trichomonas vaginalis AGC family protein kinase 0.0337 0.2583 0.3102
Brugia malayi MH2 domain containing protein 0.0144 0.0791 0.0829
Entamoeba histolytica casein kinase, putative 0.0116 0.0529 0.0616
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0397 0.3143 0.3755
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0098 0.0359 0.0411
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.2009 0.2397
Loa Loa (eye worm) hypothetical protein 0.0913 0.7943 0.8591
Brugia malayi Protein kinase domain containing protein 0.0212 0.1419 0.151
Echinococcus multilocularis casein kinase i 0.0125 0.0617 0.0711
Echinococcus multilocularis tyrosine protein kinase Blk 0.0246 0.1736 0.206
Schistosoma mansoni hypothetical protein 0.0113 0.0506 0.0588
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0062 0.0031 0.0033
Schistosoma mansoni tyrosine kinase 0.0088 0.0265 0.0298
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0086 0.0248 0.0278
Echinococcus granulosus neuroglian 0.0117 0.0539 0.0514
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0886 0.1045
Loa Loa (eye worm) hypothetical protein 0.0063 0.0035 0.0038
Giardia lamblia Kinase, AGC AKT 0.0135 0.0704 0.0827
Schistosoma mansoni hypothetical protein 0.0082 0.0216 0.0239
Entamoeba histolytica protein kinase, putative 0.0076 0.0158 0.017
Brugia malayi Immunoglobulin I-set domain containing protein 0.011 0.0477 0.0488
Brugia malayi SH2 domain containing protein 0.0062 0.0031 0.0004
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0173 0.1063 0.1248
Echinococcus multilocularis cyclin dependent kinase 1 0.0954 0.8326 1
Trichomonas vaginalis STE family protein kinase 0.01 0.0383 0.0459
Brugia malayi Casein kinase II, alpha chain 0.0116 0.0529 0.0544
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0117 0.0536 0.0625
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0156 0.0902 0.1065
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0176 0.1083 0.1283
Echinococcus multilocularis raf serine:threonine protein kinase 0.0091 0.0294 0.0322
Trichomonas vaginalis CK1 family protein kinase 0.0125 0.0617 0.0741
Echinococcus granulosus serine threonine protein kinase nrc 0.0179 0.1114 0.109
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0182 0.114 0.1233
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0888 0.1048
Schistosoma mansoni hypothetical protein 0.0062 0.0031 0.0017
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0116 0.0529 0.0572
Schistosoma mansoni signal transduction protein lnk-related 0.0062 0.0031 0.0017
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.01 0.0383 0.0428
Entamoeba histolytica casein kinase, putative 0.0125 0.0617 0.0722
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0064 0.0045 0.0054
Brugia malayi Protein kinase domain containing protein 0.0115 0.052 0.0535
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.033 0.0365
Schistosoma mansoni growth factor receptor-bound protein 0.0104 0.0418 0.0483
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0062 0.0031 0.0005
Schistosoma mansoni tyrosine kinase 0.0353 0.2731 0.3267
Echinococcus granulosus titin 0.0083 0.022 0.0194
Brugia malayi Temporarily assigned gene name protein 59 0.0144 0.0786 0.0824
Brugia malayi Protein kinase domain containing protein 0.0673 0.5705 0.6159
Entamoeba histolytica protein kinase, putative 0.01 0.0382 0.0439
Brugia malayi Protein kinase domain containing protein 0.0205 0.1356 0.1442
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0072 0.0116 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.1231 0.1461
Schistosoma mansoni protein kinase 0.0081 0.0206 0.0228
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0998 0.1199
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0228 0.157 0.1548
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0103 0.041 0.0443
Loa Loa (eye worm) STAT protein 0.0062 0.0031 0.0033
Loa Loa (eye worm) hypothetical protein 0.011 0.0477 0.0516
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.023 0.159 0.1883
Schistosoma mansoni SH2A 0.0062 0.0031 0.0017
Brugia malayi SH2 domain containing protein 0.026 0.1867 0.1996
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0382 0.0459
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Loa Loa (eye worm) hypothetical protein 0.016 0.0937 0.1014
Echinococcus granulosus tyrosine protein kinase HCK 0.0183 0.1156 0.1132
Echinococcus granulosus SH2 motif 0.0062 0.0031 0.0004
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.0027 0.0029
Echinococcus granulosus tyrosine protein kinase Fyn 0.0287 0.2124 0.2102
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.0323 0.0368
Loa Loa (eye worm) hypothetical protein 0.0132 0.0682 0.0738
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0287 0.2124 0.2527
Onchocerca volvulus 0.0104 0.0421 0.0756
Schistosoma mansoni serine/threonine-protein kinase 0.0186 0.1185 0.1406
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0148 0.0824 0.0799
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0245 0.1729 0.1706
Entamoeba histolytica protein kinase, putative 0.0104 0.0413 0.0477
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0421 0.0506
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.033 0.0376
Plasmodium vivax unspecified product 0.0116 0.0529 0.0616
Schistosoma mansoni neuroglian 0.0062 0.0027 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.1416 0.1683
Leishmania major protein kinase A catalytic subunit 0.0086 0.0248 0.0278
Trypanosoma cruzi cdc2-related kinase 1 0.0954 0.8326 1
Echinococcus granulosus tyrosine kinase 0.0246 0.1736 0.1714
Trypanosoma cruzi cyclin, putative 0.0083 0.0226 0.0252
Loa Loa (eye worm) TK protein kinase 0.0183 0.1156 0.125
Entamoeba histolytica cell division protein kinase 2, putative 0.0954 0.8326 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.065 0.0703
Leishmania major protein kinase, putative 0.0166 0.0998 0.1181
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0329 0.2512 0.2716
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0998 0.1181
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Brugia malayi Protein kinase domain containing protein 0.0504 0.4137 0.4458
Plasmodium falciparum serine/threonine protein kinase KIN 0.0104 0.0418 0.0482
Echinococcus multilocularis casein kinase I alpha 0.0125 0.0617 0.0711
Trypanosoma cruzi p21-activated kinase 3, putative 0.0065 0.0058 0.0049
Plasmodium falciparum calcium-dependent protein kinase 5 0.0117 0.0536 0.0625
Plasmodium vivax casein kinase 1, putative 0.0125 0.0617 0.0722
Echinococcus granulosus dual specificity protein kinase clk2 0.0176 0.1083 0.1059
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0176 0.1083 0.1283
Giardia lamblia Kinase, CMGC DYRK 0.01 0.0382 0.0439
Schistosoma mansoni protein kinase 0.0116 0.0529 0.0616
Trypanosoma cruzi casein kinase, putative 0.0125 0.0617 0.0722
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0205 0.1356 0.1333
Plasmodium falciparum cGMP-dependent protein kinase 0.0154 0.0886 0.1045
Brugia malayi SH2 domain containing protein 0.0062 0.0031 0.0004
Echinococcus multilocularis titin 0.0083 0.022 0.0233
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.052 0.0563
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0359 0.0431
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Echinococcus multilocularis casein kinase I delta 0.0125 0.0617 0.0711
Brugia malayi hypothetical protein 0.0062 0.0031 0.0004
Echinococcus granulosus SH2 domain containing adapter protein F 0.0062 0.0031 0.0004
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0062 0.0031 0.0005
Loa Loa (eye worm) TK/EGFR protein kinase 0.0682 0.5791 0.6263
Schistosoma mansoni tyrosine kinase 0.0397 0.3146 0.3766
Trichomonas vaginalis CMGC family protein kinase 0.0954 0.8326 1
Echinococcus multilocularis nervana 2 0.0138 0.0731 0.0849
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0211 0.1416 0.1531
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0154 0.0886 0.1035
Echinococcus multilocularis Immunoglobulin 0.0093 0.0315 0.0346
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.1231 0.1461
Onchocerca volvulus 0.0366 0.2859 0.5476
Schistosoma mansoni nck2/grb4 0.0104 0.0418 0.0483
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0176 0.1083 0.1283
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0101 0.0385 0.0432
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.1063 0.1259
Plasmodium falciparum calcium-dependent protein kinase 1 0.0117 0.0536 0.0625
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0117 0.0536 0.0625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.022 0.0209
Entamoeba histolytica protein kinase, putative 0.0118 0.0549 0.064
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0998 0.1199
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0176 0.1083 0.1283
Echinococcus multilocularis SH2 motif 0.0062 0.0031 0.0005
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0205 0.1356 0.1602
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0231 0.1598 0.1729
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0382 0.0459
Echinococcus multilocularis calcium dependent protein kinase 0.0076 0.0154 0.0152
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0062 0.0031 0.0005
Plasmodium vivax glycogen synthase kinase 3, putative 0.0148 0.0824 0.0972
Brugia malayi Protein kinase domain containing protein 0.0115 0.052 0.0535
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.1191 0.1413
Loa Loa (eye worm) hypothetical protein 0.0141 0.0761 0.0823
Schistosoma mansoni tensin-related 0.0062 0.0031 0.0017
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0186 0.1185 0.1406
Plasmodium falciparum calcium-dependent protein kinase 2 0.0117 0.0536 0.0625
Onchocerca volvulus 0.0115 0.052 0.0948
Echinococcus granulosus expressed conserved protein 0.0062 0.0031 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.2009 0.2397
Loa Loa (eye worm) hypothetical protein 0.0099 0.0375 0.0406
Trypanosoma cruzi cyclin 6, putative 0.0083 0.0226 0.0252
Brugia malayi SRC-1 0.0287 0.2124 0.2274
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0219 0.1489 0.161
Plasmodium falciparum calcium-dependent protein kinase 4 0.0117 0.0536 0.0625
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0182 0.114 0.1351
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0017 0.0021
Echinococcus multilocularis twitchin 0.0065 0.0058 0.0037
Echinococcus granulosus serine:threonine kinase SAD 1 0.0104 0.0418 0.0392
Brugia malayi Tensin 0.0062 0.0031 0.0004
Schistosoma mansoni protein kinase 0.0125 0.0617 0.0722
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0065 0.0058 0.0062
Loa Loa (eye worm) CDC7 protein kinase 0.0104 0.0421 0.0456
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0104 0.0418 0.0482
Brugia malayi putative serine/threonine kinase SADA gamma 0.0104 0.0418 0.0424
Echinococcus multilocularis neuroglian 0.0117 0.0539 0.0617
Schistosoma mansoni tensin 0.0062 0.0031 0.0017
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0104 0.0418 0.0453
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Loa Loa (eye worm) hypothetical protein 0.0132 0.0674 0.0729
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0133 0.0684 0.0658
Loa Loa (eye worm) TK/ALK protein kinase 0.0316 0.2389 0.2584
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0555 0.4611 0.4597
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.033 0.0357
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0397 0.3143 0.3124
Echinococcus granulosus SH2 domain containing protein 7 0.0062 0.0031 0.0004
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0187 0.1191 0.1167
Schistosoma mansoni cell adhesion molecule 0.0131 0.0666 0.0781
Brugia malayi C1-like domain containing protein 0.017 0.1033 0.1091
Echinococcus granulosus protein kinase c epsilon type 0.0231 0.1598 0.1576
Trypanosoma cruzi cdc2-related kinase 3 0.0954 0.8326 1
Echinococcus granulosus nervana 2 0.0138 0.0731 0.0706
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0336 0.0403
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.033 0.0396
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0245 0.1729 0.205
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.01 0.0383 0.0356
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0086 0.0248 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.0954 0.8326 1
Onchocerca volvulus 0.0325 0.2476 0.4735
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0421 0.0506
Trypanosoma cruzi casein kinase, putative 0.0125 0.0617 0.0722
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Echinococcus multilocularis insulin receptor 0.0501 0.4108 0.4917
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.3143 0.3762
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0225 0.0251
Schistosoma mansoni serine/threonine kinase 0.0246 0.1739 0.2072
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.052 0.0563
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0086 0.0248 0.0278
Giardia lamblia Kinase, CMGC GSK 0.0148 0.0824 0.0972
Loa Loa (eye worm) SH2 domain-containing protein 0.0062 0.0031 0.0033
Onchocerca volvulus 0.0125 0.0617 0.1135
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0182 0.114 0.1351
Schistosoma mansoni tyrosine kinase 0.0616 0.5181 0.6215
Trypanosoma brucei protein kinase, putative 0.0098 0.0359 0.0411
Loa Loa (eye worm) hypothetical protein 0.0673 0.5705 0.617
Schistosoma mansoni suppressor of cytokine signaling 0.0062 0.0031 0.0017
Brugia malayi Protein kinase domain containing protein 0.0246 0.1739 0.1857
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0443 0.3574 0.4274
Brugia malayi cell division control protein 2 homolog 0.0954 0.8326 0.9002
Loa Loa (eye worm) hypothetical protein 0.011 0.0477 0.0516
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0382 0.0439
Echinococcus multilocularis SH2 motif 0.0062 0.0031 0.0005
Onchocerca volvulus 0.0071 0.0114 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.1729 0.206
Schistosoma mansoni protein kinase 0.0488 0.3985 0.4776
Echinococcus multilocularis expressed protein 0.0097 0.0352 0.0392
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.033 0.0396
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0418 0.0482
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0148 0.0824 0.0972
Brugia malayi SH2 domain containing protein 0.0062 0.0031 0.0004
Entamoeba histolytica protein kinase domain containing protein 0.0166 0.0998 0.1181
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0336 0.0383
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0382 0.0459
Echinococcus granulosus hypothetical protein 0.0134 0.07 0.0675
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Trypanosoma cruzi aurora B kinase, putative 0.0166 0.0998 0.1181
Trichomonas vaginalis AGC family protein kinase 0.0337 0.2583 0.3102
Schistosoma mansoni serine/threonine protein kinase 0.0954 0.8326 1
Brugia malayi Protein kinase domain 0.01 0.0383 0.0386
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0397 0.3143 0.6026
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0062 0.0031 0.0004
Echinococcus multilocularis dual specificity 0.0141 0.0758 0.088
Brugia malayi Protein kinase domain containing protein 0.0214 0.1443 0.1536
Loa Loa (eye worm) hypothetical protein 0.0155 0.0888 0.096
Echinococcus multilocularis protein kinase shaggy 0.0148 0.0824 0.0961
Leishmania major casein kinase II, putative 0.0116 0.0529 0.0616
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0529 0.0635
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0117 0.0536 0.0625
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0017 0.0021
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0086 0.0248 0.0278
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0098 0.0359 0.0388
Plasmodium falciparum glycogen synthase kinase 3 0.0148 0.0824 0.0972
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0098 0.0359 0.0411
Entamoeba histolytica protein kinase, putative 0.01 0.0383 0.044
Echinococcus granulosus tyrosine protein kinase Fyn 0.0287 0.2124 0.2102
Schistosoma mansoni protein kinase 0.0205 0.1356 0.1612
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0017 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0205 0.1356 0.1467
Echinococcus multilocularis casein kinase I alpha 0.0125 0.0617 0.0711
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0104 0.0418 0.0471
Brugia malayi Hr1 repeat family protein 0.0336 0.2574 0.2762
Echinococcus multilocularis SHC transforming protein 3 0.0062 0.0031 0.0005
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0148 0.0824 0.0892
Echinococcus granulosus hypothetical protein 0.0062 0.0031 0.0004
Schistosoma mansoni tyrosine kinase 0.0273 0.1993 0.2378
Loa Loa (eye worm) TK protein kinase 0.032 0.2423 0.262
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0062 0.0031 0.0004
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0093 0.0315 0.0346
Echinococcus granulosus aurora kinase A 0.0166 0.0998 0.0974
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0888 0.1048
Echinococcus multilocularis serine:threonine protein kinase 0.0132 0.0674 0.0779
Trypanosoma cruzi casein kinase, putative 0.0125 0.0617 0.0722
Echinococcus granulosus suppressor of cytokine signaling 7 0.0062 0.0031 0.0004
Brugia malayi STAT protein, DNA binding domain containing protein 0.0062 0.0031 0.0004
Brugia malayi ephrin receptor 1 precursor 0.0086 0.0252 0.0244
Schistosoma mansoni tensin 0.0062 0.0031 0.0017
Giardia lamblia Kinase, NEK 0.0156 0.0902 0.1065
Echinococcus multilocularis 0.0193 0.1249 0.1472
Echinococcus multilocularis casein kinase I delta 0.0125 0.0617 0.0711
Entamoeba histolytica protein kinase, putative 0.0337 0.2583 0.3088
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0488 0.3985 0.477
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.1598 0.1903
Plasmodium vivax serine/threonine kinase-1, putative 0.0176 0.1083 0.1283
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0418 0.0482
Schistosoma mansoni protein kinase 0.0488 0.3985 0.4776
Trypanosoma brucei mitotic cyclin 6 0.0083 0.0226 0.0252
Loa Loa (eye worm) hypothetical protein 0.0082 0.0216 0.0233
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0104 0.0418 0.0482
Echinococcus multilocularis CDC7 cell division cycle 7 0.0104 0.0421 0.0475
Echinococcus multilocularis cyclin B 0.0083 0.0226 0.024
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0125 0.0617 0.0722
Brugia malayi Immunoglobulin I-set domain containing protein 0.0707 0.6023 0.6504
Plasmodium vivax calcium-dependent protein kinase, putative 0.0117 0.0536 0.0625
Entamoeba histolytica protein kinase, putative 0.0148 0.0824 0.0972
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0287 0.2124 0.2102
Trichomonas vaginalis cyclin A, putative 0.0083 0.0226 0.0272
Echinococcus granulosus NCK adaptor protein 0.0104 0.0418 0.0392
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1083 0.1283
Echinococcus granulosus mitogen activated protein kinase 0.0098 0.0359 0.0333
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0504 0.4137 0.4474
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0824 0.099
Entamoeba histolytica PH domain containing protein kinase, putative 0.0093 0.0319 0.0363
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0098 0.0359 0.0411
Loa Loa (eye worm) hypothetical protein 0.0137 0.0726 0.0786
Echinococcus multilocularis ephrin type A receptor 4 A 0.0124 0.0603 0.0694
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0104 0.0418 0.0482
Onchocerca volvulus Tyrosine kinase homolog 0.0618 0.5195 1
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.0674 0.0809
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0093 0.0315 0.0358
Brugia malayi hypothetical protein 0.0137 0.0726 0.0759
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0707 0.6023 0.6515
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0065 0.0058 0.0069
Echinococcus multilocularis tyrosine protein kinase shark 0.0353 0.2731 0.3259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Onchocerca volvulus 0.0104 0.0421 0.0756
Echinococcus granulosus serine:threonine protein kinase 0.0132 0.0674 0.0648
Entamoeba histolytica PH domain containing protein kinase, putative 0.0186 0.1185 0.1406
Brugia malayi SH2 domain containing protein 0.0062 0.0031 0.0004
Toxoplasma gondii aurora kinase 0.0166 0.0998 0.1181
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0336 0.0403
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0529 0.0635
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.01 0.0382 0.0439
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0101 0.0385 0.0443
Giardia lamblia Kinase, CMGC CLK 0.0176 0.1083 0.1283
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.052 0.0563
Trypanosoma brucei cdc2-related kinase 3 0.0954 0.8326 1
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.052 0.0563
Echinococcus multilocularis serine:threonine protein kinase N2 0.0191 0.1231 0.1451
Echinococcus multilocularis dual specificity 0.01 0.0382 0.0428
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0065 0.0058 0.0049
Echinococcus multilocularis hypothetical protein 0.0113 0.0506 0.0577
Schistosoma mansoni hypothetical protein 0.0205 0.1354 0.1609
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0148 0.0824 0.0961
Trypanosoma brucei polo-like protein kinase 0.0095 0.033 0.0376
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0191 0.1231 0.1451
Brugia malayi casein kinase I 0.0125 0.0617 0.064
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Loa Loa (eye worm) hypothetical protein 0.0093 0.0318 0.0344
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.0529 0.0616
Echinococcus granulosus raf serine:threonine protein kinase 0.0091 0.0294 0.0268
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Echinococcus multilocularis geminin 0.0205 0.1354 0.1599
Trichomonas vaginalis STE family protein kinase 0.0076 0.0158 0.019
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0141 0.0758 0.0891
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0285 0.2102 0.25
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.052 0.0563
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0101 0.0385 0.0443
Echinococcus multilocularis growth factor receptor bound protein 2 0.0104 0.0418 0.0472
Echinococcus granulosus casein kinase i 0.0125 0.0617 0.0592
Trichomonas vaginalis AGC family protein kinase 0.0156 0.0902 0.1083
Loa Loa (eye worm) hypothetical protein 0.0155 0.0888 0.096
Entamoeba histolytica protein kinase domain containing protein 0.0141 0.0758 0.0891
Loa Loa (eye worm) hypothetical protein 0.0083 0.0226 0.0245
Leishmania major cyclin 0.0083 0.0226 0.0252
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0359 0.0431
Brugia malayi Variant SH3 domain containing protein 0.0101 0.0385 0.0389
Loa Loa (eye worm) TK/ABL protein kinase 0.0346 0.2668 0.2886
Leishmania major protein kinase, putative 0.0176 0.1083 0.1283
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0673 0.5705 0.617
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0065 0.0058 0.0033
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0072 0.0116 0.014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.057 0.0617
Giardia lamblia Kinase, CMGC CDK 0.0954 0.8326 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Brugia malayi Egg laying defective protein 4 0.0154 0.0886 0.0931
Loa Loa (eye worm) hypothetical protein 0.0306 0.2293 0.248
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0176 0.1083 0.1283
Schistosoma mansoni kinase 0.0219 0.1488 0.1771
Echinococcus multilocularis dual specificity protein kinase clk2 0.0176 0.1083 0.1272
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0306 0.2293 0.2457
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0248 0.0298
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Schistosoma mansoni hypothetical protein 0.0062 0.0031 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0017 0.0021
Leishmania major protein kinase, putative 0.0094 0.0323 0.0368
Entamoeba histolytica SH2 domain containing protein 0.0062 0.0031 0.0017
Brugia malayi Serine/threonine-protein kinase SULU 0.0252 0.1793 0.1915
Schistosoma mansoni vav2 0.0108 0.0457 0.0529
Echinococcus granulosus tensin 0.0062 0.0031 0.0004
Trypanosoma brucei cdc2-related kinase 1 0.0954 0.8326 1
Trypanosoma cruzi casein kinase, putative 0.0125 0.0617 0.0722
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0125 0.0617 0.0667
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0418 0.0482
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0104 0.0418 0.0482
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.033 0.0376
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0156 0.0902 0.1065
Trypanosoma brucei protein kinase, putative 0.0148 0.0824 0.0972
Echinococcus granulosus cyclin dependent kinase 5 0.0954 0.8326 0.8321
Loa Loa (eye worm) hypothetical protein 0.0346 0.2668 0.2886
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0287 0.2124 0.2527
Mycobacterium ulcerans haloalkane dehalogenase 0.092 0.8008 1
Echinococcus multilocularis tyrosine kinase 0.0115 0.052 0.0594
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0211 0.1416 0.1673
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.2102 0.2509
Onchocerca volvulus 0.0541 0.4481 0.8617
Schistosoma mansoni serine/threonine-protein kinase 0.0186 0.1185 0.1406
Echinococcus granulosus tyrosine kinase 0.0115 0.052 0.0495
Echinococcus multilocularis rac serine:threonine kinase 0.0186 0.1185 0.1395
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.033 0.0328
Schistosoma mansoni serine/threonine protein kinase 0.0443 0.3574 0.4281
Brugia malayi hypothetical protein 0.011 0.0477 0.0488
Loa Loa (eye worm) hypothetical protein 0.0091 0.0296 0.032
Brugia malayi map kinase activated protein kinase protein 2 0.0443 0.3574 0.3847
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0382 0.0459
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0086 0.0248 0.0239
Giardia lamblia Kinase, CMGC CK2 0.0116 0.0529 0.0616
Onchocerca volvulus Serine\/threonine kinase homolog 0.0187 0.1191 0.2247
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.01 0.0382 0.0385
Echinococcus granulosus tyrosine protein kinase Src64B 0.0287 0.2124 0.2102
Loa Loa (eye worm) hypothetical protein 0.0155 0.0888 0.096
Schistosoma mansoni tensin 0.0062 0.0031 0.0017
Echinococcus multilocularis 0.0062 0.0031 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0337 0.2583 0.3102
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0086 0.0248 0.0278
Loa Loa (eye worm) TK/FER protein kinase 0.026 0.1867 0.2019
Echinococcus granulosus activin receptor type 0.0094 0.0323 0.0296
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.052 0.0563
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0294 0.0334
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0086 0.0248 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0058 0.0049
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0166 0.0992 0.0967
Echinococcus multilocularis cyclin dependent kinase 0.0954 0.8326 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0062 0.0031 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0216 0.0205
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0097 0.0352 0.0404
Loa Loa (eye worm) AGC/AKT protein kinase 0.0337 0.2583 0.2793
Echinococcus granulosus tyrosine protein kinase Fps85D 0.026 0.1867 0.1845
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.033 0.0579
Schistosoma mansoni adapter molecule crk 0.0104 0.0418 0.0483
Schistosoma mansoni vesicular amine transporter 0.0093 0.0315 0.0358
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0166 0.0998 0.1181
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0275 0.2009 0.2388
Brugia malayi Protein kinase domain containing protein 0.0337 0.2583 0.2772
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0062 0.0031 0.0004
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0246 0.1739 0.1881
Schistosoma mansoni protein kinase 0.0076 0.0158 0.017
Brugia malayi Sex muscle abnormal protein 5 0.0104 0.0418 0.0425
Loa Loa (eye worm) hypothetical protein 0.0071 0.0114 0.0123
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0173 0.1063 0.1039
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0138 0.0731 0.0849
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0115 0.0096
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0176 0.1083 0.1283
Trypanosoma brucei aurora B kinase 0.0166 0.0998 0.1181
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Brugia malayi Protein kinase domain containing protein 0.0104 0.0421 0.0428
Echinococcus granulosus roundabout 2 0.0155 0.0891 0.0866
Onchocerca volvulus 0.0083 0.022 0.0366
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0095 0.0336 0.0363
Echinococcus multilocularis protein tyrosine kinase 0.0616 0.5181 0.6211
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0191 0.1231 0.1207
Leishmania major protein kinase A catalytic subunit isoform 1 0.0086 0.0248 0.0278
Onchocerca volvulus 0.0115 0.052 0.0948
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0359 0.0431
Echinococcus multilocularis mitogen activated protein kinase 14 0.0182 0.114 0.1341
Echinococcus multilocularis activin receptor type 0.0094 0.0323 0.0356
Entamoeba histolytica cyclin, putative 0.0083 0.0226 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.0536 0.0644
Schistosoma mansoni tyrosine kinase 0.029 0.2151 0.2568
Trypanosoma cruzi cdc2-related kinase 1 0.0954 0.8326 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0166 0.0998 0.1171
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.052 0.0563
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.1729 0.206
Echinococcus granulosus protein kinase C gamma type 0.0237 0.1655 0.1632
Entamoeba histolytica protein kinase 2, putative 0.0179 0.1114 0.132
Loa Loa (eye worm) hypothetical protein 0.0514 0.4229 0.4574
Echinococcus multilocularis tensin 0.0062 0.0031 0.0005
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0138 0.0731 0.0706
Giardia lamblia Kinase, CAMK CAMKL 0.0104 0.0418 0.0482
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0062 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Trichomonas vaginalis CK1 family protein kinase 0.0125 0.0617 0.0741
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0154 0.0886 0.1045
Echinococcus granulosus casein kinase ii subunit alpha 0.0116 0.0529 0.0503
Echinococcus granulosus twitchin 0.0158 0.0922 0.0897
Echinococcus granulosus casein kinase I alpha 0.0125 0.0617 0.0592
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0529 0.0635
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0954 0.8326 0.9005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0488 0.3985 0.3969
Loa Loa (eye worm) hypothetical protein 0.0193 0.1242 0.1343
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1083 0.1283
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0117 0.0536 0.058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0223 0.1527 0.1808
Echinococcus granulosus protein kinase shaggy 0.0148 0.0824 0.0799
Trypanosoma cruzi casein kinase, putative 0.0125 0.0617 0.0722
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0086 0.0248 0.0278
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0062 0.0031 0.0017
Toxoplasma gondii AGC kinase 0.0086 0.0248 0.0278
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0287 0.2124 0.2102
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0287 0.2115 0.2516
Schistosoma mansoni protein kinase C mu 0.017 0.1033 0.1222
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Echinococcus granulosus casein kinase I gamma 0.0242 0.17 0.1678
Entamoeba histolytica protein kinase, putative 0.0095 0.0336 0.0383
Schistosoma mansoni serine/threonine kinase 0.0191 0.1231 0.1461
Loa Loa (eye worm) hypothetical protein 0.0134 0.07 0.0757
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0065 0.0058 0.0062
Brugia malayi Doublecortin family protein 0.0172 0.1054 0.1114
Echinococcus granulosus Immunoglobulin 0.0093 0.0315 0.0288
Loa Loa (eye worm) SH2 domain-containing protein 0.0062 0.0031 0.0033
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0195 0.1268 0.1495
Echinococcus granulosus tyrosine protein kinase ABL1 0.0346 0.2668 0.2648
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0141 0.0758 0.0891
Trypanosoma cruzi cyclin, putative 0.0083 0.0226 0.0252
Toxoplasma gondii casein kinase I 0.0125 0.0617 0.0722
Schistosoma mansoni serine/threonine protein kinase 0.0299 0.2228 0.2661
Trichomonas vaginalis CAMK family protein kinase 0.0133 0.0684 0.0821
Echinococcus multilocularis death associated protein kinase 1 0.0949 0.8277 0.9941
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0104 0.0418 0.0453
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0791 0.0856
Echinococcus granulosus defective proboscis extension response 0.0093 0.0315 0.0288
Plasmodium falciparum serine/threonine protein kinase 0.0097 0.0352 0.0404
Loa Loa (eye worm) protein kinase domain-containing protein 0.0242 0.17 0.1839
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0104 0.0418 0.0482
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0094 0.0323 0.0368
Entamoeba histolytica PH domain containing protein kinase, putative 0.0093 0.0319 0.0363
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0115 0.052 0.0606
Echinococcus multilocularis mitogen activated protein kinase 11 0.0182 0.114 0.1341
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0117 0.0536 0.0625
Brugia malayi Protein kinase domain containing protein 0.1053 0.9246 1
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0248 0.0278
Loa Loa (eye worm) hypothetical protein 0.0091 0.0296 0.032
Echinococcus multilocularis tyrosine protein kinase Srms 0.0246 0.1736 0.206
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0062 0.0031 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0222 0.1514 0.1818
Entamoeba histolytica protein kinase, putative 0.0329 0.2512 0.3002
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Brugia malayi Homeodomain interacting protein kinase protein 1 0.023 0.159 0.1696
Plasmodium falciparum serine/threonine protein kinase, putative 0.0166 0.0998 0.1181
Loa Loa (eye worm) hypothetical protein 0.0137 0.0729 0.0788
Brugia malayi Variant SH3 domain containing protein 0.0104 0.0418 0.0425
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0117 0.0536 0.051
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.052 0.0563
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Brugia malayi Protein kinase domain containing protein 0.032 0.2423 0.2599
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0246 0.1736 0.206
Loa Loa (eye worm) AGC/PKA protein kinase 0.0086 0.0248 0.0268
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0098 0.0359 0.0411
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0086 0.0248 0.0266
Echinococcus granulosus SH2 motif 0.0062 0.0031 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0954 0.8326 1
Echinococcus granulosus NDR protein kinase 0.0191 0.1231 0.1207
Brugia malayi Protein kinase domain containing protein 0.0501 0.4108 0.4426
Leishmania major protein kinase, putative 0.0176 0.1083 0.1283
Loa Loa (eye worm) hypothetical protein 0.0207 0.1377 0.149
Echinococcus granulosus cyclin B 0.0083 0.0226 0.02
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.01 0.0382 0.0439
Brugia malayi Protein kinase domain containing protein 0.0212 0.1427 0.1518
Brugia malayi casein kinase 1, delta 0.0125 0.0617 0.064
Brugia malayi Protein kinase domain containing protein 0.0176 0.1083 0.1145
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0125 0.0617 0.0667
Loa Loa (eye worm) hypothetical protein 0.0099 0.0375 0.0406
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0166 0.0998 0.1181
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0086 0.0248 0.0278
Echinococcus granulosus epidermal growth factor receptor 0.0682 0.5791 0.578
Loa Loa (eye worm) TK/INSR protein kinase 0.0501 0.4108 0.4443
Schistosoma mansoni growth factor receptor-bound protein 0.0106 0.0439 0.0508
Schistosoma mansoni tyrosine kinase 0.0397 0.3146 0.3766
Brugia malayi cytokine inducible SH2-containing protein 5 0.0062 0.0031 0.0004
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0518 0.427 0.5112
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0421 0.0487
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0071 0.0115 0.0125
Schistosoma mansoni protein kinase 0.0219 0.1489 0.1771
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0336 0.0403
Brugia malayi Tyrosine-protein kinase abl-1 0.0245 0.1729 0.1846
Entamoeba histolytica protein kinase, putative 0.0083 0.0225 0.0251
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0287 0.2115 0.2525
Brugia malayi Protein kinase domain containing protein 0.0397 0.3143 0.338
Onchocerca volvulus 0.0083 0.0221 0.0368
Giardia lamblia Kinase, CMGC SRPK 0.0097 0.0352 0.0404
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0371 0.29 0.3136
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0954 0.8326 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0954 0.8326 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0144 0.0793 0.0923
Echinococcus granulosus serine:threonine protein kinase N2 0.0336 0.2574 0.2553
Toxoplasma gondii histone kinase SNF1, putative 0.0104 0.0418 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0337 0.2583 0.3102
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.1739 0.2088
Echinococcus granulosus c src tyrosine kinase 0.0157 0.0908 0.0883
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0418 0.0482
Trichomonas vaginalis cyclin B, putative 0.0083 0.0226 0.0272
Trichomonas vaginalis AGC family protein kinase 0.0214 0.1443 0.1733
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0886 0.1045
Schistosoma mansoni ephrin receptor 0.007 0.0102 0.0102
Schistosoma mansoni nephrin 0.0134 0.0701 0.0824
Loa Loa (eye worm) hypothetical protein 0.0137 0.0721 0.078
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0086 0.0248 0.0278
Echinococcus granulosus CDC7 cell division cycle 7 0.0104 0.0421 0.0395
Loa Loa (eye worm) hypothetical protein 0.0117 0.0536 0.058
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0652 0.0765
Schistosoma mansoni protein kinase 0.0094 0.0323 0.0368
Loa Loa (eye worm) hypothetical protein 0.0093 0.0315 0.034
Echinococcus multilocularis SH2 domain containing protein 7 0.0062 0.0031 0.0005
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0098 0.0359 0.0411
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0299 0.2228 0.241
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.01 0.0383 0.0428
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0094 0.0323 0.0356
Trichomonas vaginalis cyclin B, putative 0.0083 0.0226 0.0272
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0095 0.0336 0.0363
Loa Loa (eye worm) hypothetical protein 0.0115 0.052 0.0563
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0086 0.0248 0.0221
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0187 0.1191 0.1288
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0214 0.1443 0.156
Brugia malayi Protein kinase domain containing protein 0.0219 0.1489 0.1585
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0058 0.0049
Trichomonas vaginalis cyclin B, putative 0.0083 0.0226 0.0272
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0173 0.106 0.1273
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0148 0.0824 0.0972
Schistosoma mansoni GTPase activating protein 0.0062 0.0031 0.0017
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0113 0.0504 0.0478
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.033 0.0396
Trypanosoma brucei casein kinase I, isoform 2 0.0125 0.0617 0.0722
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0083 0.0225 0.0239
Schistosoma mansoni tyrosine kinase 0.0287 0.2124 0.2536
Brugia malayi Stress-activated protein kinase jnk-1 0.0299 0.2228 0.2388
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0273 0.1993 0.2369
Trichomonas vaginalis AGC family protein kinase 0.0214 0.1443 0.1733
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0083 0.0225 0.0199
Echinococcus granulosus calcium activated potassium channel 0.0155 0.0888 0.0864
Echinococcus granulosus dual specificity 0.0141 0.0758 0.0733
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.017 0.1033 0.1091
Echinococcus multilocularis aurora kinase A 0.0166 0.0998 0.1171
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0097 0.0352 0.0381
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0148 0.0824 0.0892
Giardia lamblia Kinase, CAMK CAMKL 0.0104 0.0418 0.0482
Schistosoma mansoni serine/threonine protein kinase 0.0336 0.2574 0.3077
Entamoeba histolytica protein kinase domain containing protein 0.0148 0.0824 0.0972
Brugia malayi SH2 domain containing protein 0.0062 0.0031 0.0004
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0104 0.0418 0.0452
Echinococcus granulosus tyrosine protein kinase Lyn 0.0329 0.2506 0.2486
Echinococcus granulosus tyrosine protein kinase shark 0.0353 0.2731 0.2712
Brugia malayi Furin-like cysteine rich region family protein 0.0682 0.5791 0.6252
Schistosoma mansoni ephrin receptor 0.0124 0.0603 0.0705
Schistosoma mansoni serine/threonine protein kinase 0.023 0.159 0.1893
Trichomonas vaginalis AGC family protein kinase 0.0337 0.2583 0.3102
Echinococcus granulosus cGMP dependent protein kinase 1 0.0154 0.0886 0.0861
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0443 0.3574 0.3557
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0062 0.0031 0.0005
Echinococcus multilocularis dual specificity 0.01 0.0382 0.0428
Plasmodium falciparum protein serine/threonine kinase-1 0.0176 0.1083 0.1283
Echinococcus multilocularis mitogen activated protein kinase 0.0098 0.0359 0.04
Echinococcus multilocularis mitogen activated protein kinase 3 0.0098 0.0359 0.04
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0176 0.1083 0.1171
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0179 0.1114 0.132
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.033 0.0396
Schistosoma mansoni tyrosine kinase 0.0157 0.0908 0.1072
Onchocerca volvulus 0.0084 0.0235 0.0394
Onchocerca volvulus 0.0115 0.052 0.0948
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0529 0.0635
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0154 0.0886 0.1035
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0093 0.0315 0.0358
Echinococcus granulosus mitogen activated protein kinase 3 0.0098 0.0359 0.0333
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Echinococcus granulosus Protein kinase C brain isozyme 0.0275 0.2009 0.1987
Echinococcus multilocularis protein kinase c iota type 0.0322 0.2444 0.2912
Loa Loa (eye worm) hypothetical protein 0.0063 0.0035 0.0038
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0245 0.1729 0.1706
Toxoplasma gondii CMGC kinase, CK2 family 0.0116 0.0529 0.0616
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0098 0.0359 0.0411
Echinococcus granulosus dual specificity 0.01 0.0382 0.0356
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Giardia lamblia Kinase, NEK 0.0156 0.0902 0.1065
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.033 0.0376
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0095 0.0331 0.0378
Plasmodium falciparum protein kinase 5 0.0954 0.8326 1
Plasmodium vivax serine/threonine protein kinase, putative 0.0097 0.0352 0.0404
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Giardia lamblia Kinase, CMGC MAPK 0.0098 0.0359 0.0411
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0166 0.0998 0.1181
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0371 0.29 0.3116
Loa Loa (eye worm) AGC/NDR protein kinase 0.0191 0.1231 0.1331
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Loa Loa (eye worm) TK/EPH protein kinase 0.0143 0.0785 0.0849
Entamoeba histolytica protein kinase domain containing protein 0.01 0.0382 0.0439
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.01 0.0383 0.0356
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0285 0.2102 0.2081
Onchocerca volvulus 0.0129 0.065 0.1199
Entamoeba histolytica hypothetical protein 0.0141 0.0758 0.0891
Echinococcus multilocularis epidermal growth factor receptor 0.0682 0.5791 0.6946
Schistosoma mansoni tyrosine kinase 0.0414 0.3303 0.3955
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0182 0.114 0.1351
Onchocerca volvulus 0.0115 0.052 0.0948
Entamoeba histolytica protein kinase, putative 0.0337 0.2583 0.3088
Echinococcus granulosus c-Jun N-terminal kinases 0.0299 0.2228 0.2207
Echinococcus granulosus Glutaredoxin protein 5 0.0138 0.0731 0.0706
Brugia malayi Fibronectin type III domain containing protein 0.011 0.0477 0.0488
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0141 0.0758 0.0891
Schistosoma mansoni tyrosine kinase 0.0287 0.2124 0.2536
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0083 0.0225 0.0239
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0117 0.0536 0.0552
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0117 0.0536 0.0625
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Trypanosoma brucei protein kinase, putative 0.0094 0.0323 0.0368
Trypanosoma brucei SNF1-related protein kinases, putative 0.0104 0.0418 0.0482
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0141 0.0758 0.0819
Brugia malayi Tyrosine-protein kinase abl-1 0.0143 0.0777 0.0814
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0187 0.1191 0.1403
Echinococcus granulosus ephrin type A receptor 4 A 0.0124 0.0603 0.0577
Echinococcus multilocularis mitogen activated protein kinase 14 0.0182 0.114 0.1341
Plasmodium falciparum calcium-dependent protein kinase 3 0.0117 0.0536 0.0625
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.1063 0.1259
Schistosoma mansoni tyrosine kinase 0.0397 0.3146 0.3766
Trichomonas vaginalis CK1 family protein kinase 0.0125 0.0617 0.0741
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0062 0.0031 0.0005
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.01 0.0382 0.0439
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0178 0.1109 0.12
Echinococcus granulosus cGMP dependent protein kinase 1 0.0154 0.0886 0.0861
Echinococcus granulosus dual specificity 0.01 0.0382 0.0356
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0888 0.1048
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0791 0.0856
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0094 0.0323 0.0368
Echinococcus granulosus cyclin dependent kinase 1 0.0954 0.8326 0.8321
Brugia malayi Protein kinase c protein 2 0.0125 0.0611 0.0634
Leishmania major protein kinase, putative 0.0117 0.0536 0.0625
Echinococcus granulosus fibroblast growth factor receptor 4 0.0273 0.1993 0.1971
Brugia malayi Protein kinase domain containing protein 0.0115 0.052 0.0535
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0081 0.0206 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0536 0.0625
Echinococcus granulosus casein kinase I delta 0.0125 0.0617 0.0592
Echinococcus granulosus serine:threonine protein kinase N2 0.0144 0.0793 0.0768
Brugia malayi Fes/CIP4 homology domain containing protein 0.0126 0.0624 0.0647
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0086 0.0248 0.0221
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.01 0.0383 0.0356
Schistosoma mansoni protein kinase 0.0094 0.0323 0.0368
Entamoeba histolytica p21-activated kinase 0.0108 0.0454 0.0526
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0176 0.1083 0.1283
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.033 0.0304
Loa Loa (eye worm) SRC-1 0.0287 0.2124 0.2297
Brugia malayi Protein kinase domain containing protein 0.0242 0.17 0.1815
Entamoeba histolytica cell division protein kinase 2, putative 0.0954 0.8326 1
Trichomonas vaginalis CAMK family protein kinase 0.0133 0.0684 0.0821
Echinococcus granulosus homeodomain interacting protein kinase 3 0.023 0.159 0.1567
Echinococcus multilocularis tyrosine protein kinase Abl 0.0245 0.1729 0.2051
Entamoeba histolytica protein kinase, putative 0.0117 0.0536 0.0625
Trichomonas vaginalis cyclins, putative 0.0083 0.0226 0.0272
Schistosoma mansoni cell adhesion molecule 0.0062 0.0027 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0529 0.0635
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0287 0.2124 0.2527
Trypanosoma cruzi CYC2-like cyclin, putative 0.0083 0.0226 0.0252
Echinococcus granulosus dual specificity 0.01 0.0382 0.0356
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Echinococcus granulosus geminin 0.0205 0.1354 0.133
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Brugia malayi p70 ribosomal S6 kinase beta 0.0329 0.2512 0.2695
Leishmania major casein kinase, putative 0.0125 0.0617 0.0722
Echinococcus granulosus tyrosine protein kinase Srms 0.0569 0.4742 0.4728
Echinococcus granulosus casein kinase I delta 0.0125 0.0617 0.0592
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0285 0.2102 0.2273
Giardia lamblia Kinase, NEK 0.0156 0.0902 0.1065
Entamoeba histolytica protein kinase, putative 0.0084 0.0229 0.0255
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.1793 0.2137
Echinococcus multilocularis serine:threonine protein kinase 38 0.0191 0.1231 0.1451
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.052 0.0563
Loa Loa (eye worm) TK/ROR protein kinase 0.0077 0.0165 0.0178
Echinococcus granulosus tyrosine protein kinase Src42A 0.0287 0.2124 0.2102
Brugia malayi Protein kinase domain containing protein 0.0115 0.052 0.0535
Echinococcus granulosus casein kinase I alpha 0.0125 0.0617 0.0592
Trichomonas vaginalis STE family protein kinase 0.01 0.0383 0.0459
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0454 0.367 0.439
Giardia lamblia Kinase, AGC PKA 0.0179 0.1114 0.132
Giardia lamblia Kinase, CK1 Casein kinase 0.0125 0.0617 0.0722
Echinococcus multilocularis casein kinase I alpha 0.0125 0.0617 0.0711
Brugia malayi Protein kinase domain containing protein 0.0073 0.0133 0.0114
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0389 0.3069 0.3319
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Loa Loa (eye worm) AGC/PKG protein kinase 0.0154 0.0886 0.0958
Echinococcus multilocularis expressed conserved protein 0.0154 0.0886 0.1035
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0086 0.0248 0.0221
Loa Loa (eye worm) hypothetical protein 0.0082 0.0216 0.0234
Echinococcus granulosus N chimaerin 0.0101 0.0385 0.0359
Echinococcus granulosus SHC transforming protein 3 0.0062 0.0031 0.0004
Brugia malayi Protein kinase domain containing protein 0.0132 0.0674 0.0701
Schistosoma mansoni tyrosine kinase 0.045 0.3635 0.4355
Brugia malayi Protein kinase domain containing protein 0.0115 0.052 0.0535
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0064 0.0045 0.0054
Loa Loa (eye worm) hypothetical protein 0.0232 0.1606 0.1737
Entamoeba histolytica protein kinase, putative 0.0191 0.1231 0.1461
Echinococcus multilocularis tyrosine protein kinase HCK 0.0183 0.1156 0.136
Echinococcus multilocularis casein kinase ii subunit alpha 0.0116 0.0529 0.0604
Schistosoma mansoni tyrosine kinase 0.0501 0.4108 0.4923
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0062 0.0031 0.0033
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0117 0.0536 0.0613
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0101 0.0385 0.0417
Echinococcus multilocularis serine:threonine protein kinase N2 0.0336 0.2574 0.3069
Loa Loa (eye worm) hypothetical protein 0.0137 0.0729 0.0788
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0104 0.0418 0.0482
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0299 0.2228 0.2653
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0086 0.0248 0.0278
Plasmodium falciparum protein kinase, putative 0.0094 0.0323 0.0368
Loa Loa (eye worm) hypothetical protein 0.0093 0.0315 0.034
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0252 0.1793 0.2128
Schistosoma mansoni serine/threonine protein kinase 0.0536 0.4431 0.5312
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0135 0.0704 0.0734
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0166 0.0992 0.1162
Trypanosoma cruzi cdc2-related kinase 3 0.0954 0.8326 1
Echinococcus multilocularis calcium activated potassium channel 0.0155 0.0888 0.1038
Echinococcus multilocularis 0.0134 0.07 0.0811
Echinococcus granulosus tyrosine protein kinase Src42A 0.0195 0.1268 0.1244
Loa Loa (eye worm) CAMK protein kinase 0.0083 0.022 0.0238
Echinococcus multilocularis cyclin dependent kinase 1 0.0954 0.8326 1
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0252 0.1793 0.1771
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0555 0.4611 0.5524
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0397 0.3143 0.338
Echinococcus granulosus tyrosine protein kinase Fyn 0.0287 0.2124 0.2102
Brugia malayi Protein kinase domain containing protein 0.0673 0.5705 0.6159
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.045 0.3635 0.3618
Brugia malayi hypothetical protein 0.0063 0.0035 0.0009
Loa Loa (eye worm) hypothetical protein 0.0113 0.0506 0.0547
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0287 0.2124 0.2527
Schistosoma mansoni tyrosine kinase 0.0097 0.0354 0.0406
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0359 0.0411
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0094 0.0323 0.0368
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0095 0.0336 0.0309
Entamoeba histolytica protein kinase , putative 0.0166 0.0998 0.1181
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.033 0.0396
Echinococcus granulosus epidermal growth factor receptor 0.045 0.3635 0.3618
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0117 0.0536 0.0625
Schistosoma mansoni protein kinase 0.0488 0.3985 0.4776
Schistosoma mansoni protein kinase 0.0094 0.0323 0.0368
Brugia malayi MAP kinase sur-1 0.0098 0.0359 0.036
Trichomonas vaginalis STE family protein kinase 0.0061 0.0017 0.0021
Echinococcus multilocularis nervana 2 0.0138 0.0731 0.0849
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0166 0.0998 0.1181
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0141 0.0758 0.0891
Brugia malayi SH2 domain containing protein 0.0062 0.0031 0.0004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0157 0.0908 0.1072
Echinococcus granulosus tyrosine protein kinase 0.032 0.2423 0.2402
Echinococcus multilocularis c src tyrosine kinase 0.0157 0.0908 0.1061
Echinococcus multilocularis Immunoglobulin 0.0093 0.0315 0.0346
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0117 0.0536 0.058
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0248 0.0278
Echinococcus granulosus protein tyrosine kinase 0.0616 0.5181 0.5168
Schistosoma mansoni tyrosine kinase 0.045 0.3635 0.4355
Echinococcus multilocularis tensin 0.0062 0.0031 0.0005
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.026 0.1867 0.2217
Trypanosoma cruzi Protein kinase B 0.0186 0.1185 0.1406
Entamoeba histolytica protein kinase domain containing protein 0.023 0.159 0.1893
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0132 0.0674 0.0729
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0083 0.0226 0.0252
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0077 0.0165 0.0166
Onchocerca volvulus 0.0115 0.052 0.0948
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0083 0.0225 0.0199
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0954 0.8326 0.9005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0287 0.2124 0.2527
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.033 0.0396
Brugia malayi Protein kinase domain containing protein 0.0187 0.1191 0.1263
Echinococcus multilocularis PAK box P21 Rho binding 0.0076 0.0158 0.0158
Entamoeba histolytica protein kinase domain containing protein 0.0148 0.0824 0.0972
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Trichomonas vaginalis cyclins, putative 0.0083 0.0226 0.0272
Loa Loa (eye worm) TK protein kinase 0.0246 0.1736 0.1878
Schistosoma mansoni protein kinase 0.01 0.0383 0.044
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.1083 0.1301
Echinococcus granulosus suppressor of cytokine signaling 6 0.0062 0.0031 0.0004
Brugia malayi Protein kinase domain containing protein 0.0097 0.0352 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.17 0.2025
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0397 0.3143 0.3399
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.022 0.0244
Loa Loa (eye worm) hypothetical protein 0.007 0.0102 0.011
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0077 0.0165 0.0138
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Schistosoma mansoni shc transforming protein 0.0062 0.0031 0.0017
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0252 0.1793 0.1939
Loa Loa (eye worm) hypothetical protein 0.0207 0.1377 0.149
Trichomonas vaginalis cyclins, putative 0.0083 0.0226 0.0272
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0263 0.1895 0.205
Entamoeba histolytica hypothetical protein 0.0423 0.3386 0.4055
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0117 0.0536 0.051
Loa Loa (eye worm) TK/FAK protein kinase 0.0623 0.5244 0.5671
Schistosoma mansoni titin 0.0083 0.022 0.0244
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0081 0.0206 0.018
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0179 0.1114 0.132
Entamoeba histolytica protein kinase, putative 0.0141 0.0758 0.0891
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0087 0.0257 0.0278
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Schistosoma mansoni cyclin B 0.0083 0.0226 0.0252
Plasmodium vivax protein kinase, putative 0.0069 0.0096 0.0095
Loa Loa (eye worm) TK protein kinase 0.0197 0.1286 0.1391
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0287 0.2124 0.2527
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0421 0.0506
Loa Loa (eye worm) hypothetical protein 0.0062 0.0027 0.0029
Brugia malayi serine/threonine-protein kinase PAK 7 0.0263 0.1895 0.2026
Entamoeba histolytica protein kinase, putative 0.0166 0.0998 0.1181
Echinococcus granulosus serine:threonine protein kinase 0.0132 0.0674 0.0648
Brugia malayi Protein kinase domain containing protein 0.0228 0.1571 0.1675
Giardia lamblia G2/mitotic-specific cyclin B 0.0083 0.0226 0.0252
Echinococcus multilocularis mitogen activated protein kinase 11 0.0182 0.114 0.1341
Brugia malayi protein unc-22 0.0083 0.022 0.0209
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0133 0.0684 0.0791
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0397 0.3143 0.3399
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0998 0.1199
Schistosoma mansoni tyrosine kinase 0.0682 0.5791 0.6949
Schistosoma mansoni atypical protein kinase C 0.0329 0.2507 0.2997
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0182 0.114 0.1351
Brugia malayi serine/threonine kinase 12 0.0166 0.0998 0.1054
Schistosoma mansoni serine/threonine protein kinase 0.0366 0.2859 0.342
Schistosoma mansoni tyrosine kinase 0.0157 0.0908 0.1072
Echinococcus granulosus insulin receptor 0.0501 0.4108 0.4092
Plasmodium falciparum NIMA related kinase 1 0.0156 0.0902 0.1065
Loa Loa (eye worm) hypothetical protein 0.0267 0.1933 0.2091
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0273 0.1993 0.2369
Loa Loa (eye worm) hypothetical protein 0.0086 0.0248 0.0268
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0273 0.1993 0.1971
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0132 0.0678 0.0734
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0058 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Echinococcus multilocularis Glutaredoxin protein 5 0.0138 0.0731 0.0849
Entamoeba histolytica protein kinase, putative 0.0097 0.0352 0.0404
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.01 0.0382 0.0413
Trypanosoma brucei rac serine-threonine kinase, putative 0.0337 0.2583 0.3088
Brugia malayi RhoGAP domain containing protein 0.0101 0.0385 0.0389
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0062 0.0031 0.0017
Entamoeba histolytica protein kinase, putative 0.0083 0.0225 0.0251
Echinococcus granulosus titin 0.0083 0.022 0.0194
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0287 0.2124 0.2527
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0045 0.0054
Schistosoma mansoni protein kinase 0.0166 0.0998 0.1181
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0083 0.022 0.0238
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0101 0.0385 0.0359
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0454 0.367 0.3653
Brugia malayi Protein kinase domain containing protein 0.0954 0.8326 0.9002
Schistosoma mansoni tensin-related 0.0062 0.0031 0.0017
Giardia lamblia Kinase, CDC7 0.0104 0.0421 0.0487
Loa Loa (eye worm) AUR protein kinase 0.0166 0.0998 0.108
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0172 0.1054 0.114
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.033 0.0376
Loa Loa (eye worm) hypothetical protein 0.011 0.0477 0.0516
Schistosoma mansoni suppressor of cytokine signaling 0.0062 0.0031 0.0017
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0998 0.1199
Trichomonas vaginalis AGC family protein kinase 0.0191 0.1231 0.1478
Entamoeba histolytica protein kinase, putative 0.0166 0.0998 0.1181
Schistosoma mansoni nephrin 0.0062 0.0027 0.0012
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0117 0.0536 0.0625
Brugia malayi serine/threonine-protein kinase 6 0.0166 0.0998 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Schistosoma mansoni hypothetical protein 0.0113 0.0506 0.0588
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0248 0.0278
Echinococcus multilocularis dual specificity 0.01 0.0382 0.0428
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.0983 0.1162
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0086 0.0248 0.0278
Brugia malayi hypothetical protein 0.0252 0.1793 0.1915
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.0617 0.0722
Echinococcus multilocularis epidermal growth factor receptor 0.045 0.3635 0.4348
Giardia lamblia Kinase, PLK 0.0095 0.033 0.0376
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0246 0.1736 0.1714
Trichomonas vaginalis AGC family protein kinase 0.0337 0.2583 0.3102
Plasmodium vivax protein kinase Crk2 0.0954 0.8326 1
Giardia lamblia Kinase, STE STE20 0.01 0.0383 0.044
Echinococcus granulosus cGMP dependent protein kinase 0.0154 0.0886 0.0861
Giardia lamblia Kinase, CMGC CDK 0.0954 0.8326 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0083 0.0226 0.0216
Echinococcus granulosus serine/threonine protein kinase 0.0186 0.1185 0.1161
Brugia malayi Protein kinase domain containing protein 0.0095 0.0336 0.0335
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0228 0.157 0.186
Toxoplasma gondii AGC kinase 0.0329 0.2512 0.3002
Echinococcus granulosus calcium dependent protein kinase 0.0076 0.0154 0.0127
Entamoeba histolytica PH domain containing protein kinase, putative 0.0186 0.1185 0.1406
Echinococcus multilocularis SH2 motif 0.0062 0.0031 0.0005
Loa Loa (eye worm) hypothetical protein 0.0062 0.0031 0.0033
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0148 0.0824 0.0972
Echinococcus granulosus nervana 2 0.0138 0.0731 0.0706
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0228 0.1571 0.1699
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0382 0.0459
Onchocerca volvulus 0.0155 0.0888 0.1659
Onchocerca volvulus 0.0148 0.0824 0.1536
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0211 0.1416 0.1506
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.092 0.8008 0.5
Entamoeba histolytica casein kinase 1, putative 0.0125 0.0617 0.0722
Echinococcus multilocularis serine:threonine protein kinase 0.0132 0.0674 0.0779
Trichomonas vaginalis STE family protein kinase 0.01 0.0383 0.0459
Brugia malayi Immunoglobulin I-set domain containing protein 0.0298 0.2218 0.2376
Trichomonas vaginalis CMGC family protein kinase 0.0954 0.8326 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0104 0.0413 0.0477
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0824 0.099
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Echinococcus multilocularis serine threonine protein kinase 0.0237 0.1655 0.1961
Loa Loa (eye worm) AUR protein kinase 0.0166 0.0998 0.108
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0116 0.014
Onchocerca volvulus 0.0091 0.0296 0.0513
Loa Loa (eye worm) hypothetical protein 0.0083 0.0226 0.0245
Loa Loa (eye worm) TK protein kinase 0.0298 0.2218 0.2399
Echinococcus granulosus expressed protein 0.0097 0.0352 0.0326
Giardia lamblia Kinase, AGC PKA 0.0086 0.0248 0.0278
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0095 0.0331 0.0378
Trichomonas vaginalis STE family protein kinase 0.01 0.0383 0.0459
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0062 0.0031 0.0005
Brugia malayi Protein kinase domain containing protein 0.0623 0.5244 0.5659
Entamoeba histolytica protein kinase, putative 0.0097 0.0352 0.0404
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0529 0.0635
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0117 0.0536 0.0613
Loa Loa (eye worm) hypothetical protein 0.0104 0.0418 0.0452
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0142 0.0775 0.0913
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0116 0.0529 0.0616
Giardia lamblia Kinase, CMGC GSK 0.0148 0.0824 0.0972
Entamoeba histolytica protein kinase, putative 0.0084 0.0229 0.0255
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.023 0.159 0.172
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0095 0.0336 0.0372
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0418 0.0502
Schistosoma mansoni tyrosine kinase 0.0501 0.4108 0.4923
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0954 0.8326 0.9005
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.01 0.0383 0.0428
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0443 0.3574 0.3865
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0064 0.0045 0.0054
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0148 0.0824 0.0972
Loa Loa (eye worm) AUR protein kinase 0.0166 0.0998 0.108
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0529 0.0635
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0097 0.0352 0.0404
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0382 0.0459

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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