Detailed information for compound 1377856

Basic information

Technical information
  • TDR Targets ID: 1377856
  • Name: 2-(4,9-dimethyl-7-oxo-3-phenylpyrano[6,5-g][1 ]benzoxol-8-yl)acetic acid
  • MW: 348.349 | Formula: C21H16O5
  • H donors: 1 H acceptors: 3 LogP: 3.69 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1c(=O)oc2c(c1C)c1occ(c1c(c2)C)c1ccccc1
  • InChi: 1S/C21H16O5/c1-11-8-16-19(12(2)14(9-17(22)23)21(24)26-16)20-18(11)15(10-25-20)13-6-4-3-5-7-13/h3-8,10H,9H2,1-2H3,(H,22,23)
  • InChiKey: WJQHNEWGCZKROX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(4,9-dimethyl-7-oxo-3-phenyl-pyrano[6,5-g]benzofuran-8-yl)acetic acid
  • 2-(4,9-dimethyl-7-oxo-3-phenyl-8-pyrano[6,5-g]benzofuranyl)acetic acid
  • 2-(7-keto-4,9-dimethyl-3-phenyl-pyrano[6,5-g]benzofuran-8-yl)acetic acid
  • 2-(4,9-dimethyl-7-oxo-3-phenyl-pyrano[6,5-g][1]benzoxol-8-yl)ethanoic acid
  • BB_NC-1679
  • D129-0125
  • NCGC00116341-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA damage repair protein, putative 0.0035 0.0056 0.0225
Echinococcus multilocularis alkaline phosphatase 0.0187 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.1213 0.4714 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0056 0.0118
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0058 0.0148 0.0148
Echinococcus granulosus alkaline phosphatase 0.0187 0.0655 0.0655
Loa Loa (eye worm) glutaminase 0.0314 0.1158 0.2457
Toxoplasma gondii hypothetical protein 0.0104 0.0329 0.2422
Loa Loa (eye worm) hypothetical protein 0.0076 0.0216 0.0458
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0216 0.0458
Loa Loa (eye worm) hypothetical protein 0.0054 0.0129 0.0274
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0114 0.0366 0.0776
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0228 0.1678
Loa Loa (eye worm) hypothetical protein 0.0168 0.0582 0.1234
Mycobacterium ulcerans hypothetical protein 0.0077 0.0221 0.0469
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0103 0.0417
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0221 0.0469
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0221 0.1629
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0098 0.0098
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.0944 0.6952
Loa Loa (eye worm) hypothetical protein 0.0054 0.0129 0.0274
Mycobacterium ulcerans hypothetical protein 0.0072 0.0201 0.0427
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0077 0.0565
Echinococcus granulosus expressed protein 0.0038 0.0068 0.0068
Onchocerca volvulus 0.0281 0.1027 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0079 0.0228 0.0228
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.011 0.0807
Entamoeba histolytica phosphoglycerate kinase, putative 0.0365 0.1358 0.288
Entamoeba histolytica hypothetical protein 0.011 0.0351 0.0744
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0228 0.1678
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0066 0.0139
Entamoeba histolytica hypothetical protein 0.0038 0.0066 0.0139
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0077 0.0565
Loa Loa (eye worm) hypothetical protein 0.0151 0.0515 0.1093
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0079 0.0228 0.0483
Trypanosoma brucei DNA polymerase IV, putative 0.0171 0.0591 0.2389
Trypanosoma cruzi DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Schistosoma mansoni hypothetical protein 0.0056 0.0139 0.0139
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0365 0.1358 0.288
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0057 0.014 0.014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0197 0.0197
Trichomonas vaginalis bmru protein, putative 0.0047 0.0103 0.076
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0282 0.114
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0221 0.0221
Leishmania major diacylglycerol kinase-like protein 0.0047 0.0103 0.0417
Trichomonas vaginalis DNA polymerase eta, putative 0.0171 0.0591 0.4353
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0187 0.0655 0.0655
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0647 0.2474 1
Echinococcus granulosus bloom syndrome protein 0.0073 0.0206 0.0206
Onchocerca volvulus 0.0077 0.0221 0.2155
Schistosoma mansoni hypothetical protein 0.0082 0.0241 0.0241
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0201 0.0427
Echinococcus granulosus cpg binding protein 0.0193 0.0681 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0365 0.1358 1
Treponema pallidum phosphoglycerate kinase 0.0365 0.1358 1
Echinococcus granulosus transcription factor Dp 1 0.0082 0.024 0.024
Echinococcus multilocularis tumor protein p63 0.0408 0.153 0.153
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0057 0.014 0.014
Trypanosoma brucei phosphoglycerate kinase, putative 0.0134 0.0445 0.18
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0565
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0141 0.0475 0.1921
Echinococcus multilocularis expressed protein 0.0049 0.011 0.011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0046 0.0097 0.0097
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0019 0.0143
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0134 0.0445 0.18
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0173
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0079 0.0228 0.0483
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0647 0.2474 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.008 0.0592
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0128 0.0422 0.1704
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0077 0.0565
Onchocerca volvulus 0.0072 0.0201 0.1962
Entamoeba histolytica hypothetical protein 0.011 0.0351 0.0744
Trypanosoma cruzi DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Loa Loa (eye worm) hypothetical protein 0.0054 0.0129 0.0274
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0201 0.1484
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0216 0.1589
Schistosoma mansoni cpg binding protein 0.0193 0.0681 0.0681
Trichomonas vaginalis esterase, putative 0.0077 0.0221 0.1629
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0216 0.1466
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0058 0.0148 0.0148
Trypanosoma brucei diacylglycerol kinase, putative 0.0047 0.0103 0.0417
Toxoplasma gondii ABC1 family protein 0.0077 0.0221 0.1629
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0079 0.0228 0.1452
Trypanosoma cruzi ISWI complex protein 0.0033 0.0046 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.0944 0.6952
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0042 0.008 0.0592
Onchocerca volvulus 0.0077 0.0221 0.2155
Echinococcus granulosus dna polymerase kappa 0.0171 0.0591 0.0591
Mycobacterium ulcerans DNA polymerase IV 0.0171 0.0591 0.1254
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0141 0.0475 0.1008
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.2662 0.2662
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0056 0.0225
Loa Loa (eye worm) hypothetical protein 0.0276 0.1009 0.2141
Onchocerca volvulus 0.0056 0.0139 0.1356
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0201 0.0427
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0047 0.0103 0.0417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0098 0.0098
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0036 0.0264
Toxoplasma gondii histone lysine methyltransferase SET1 0.0346 0.1283 0.9447
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0469
Leishmania major diacylglycerol kinase, putative 0.0047 0.0103 0.0417
Schistosoma mansoni bromodomain containing protein 0.0146 0.0493 0.0493
Leishmania major hypothetical protein, conserved 0.0047 0.0103 0.0417
Echinococcus multilocularis bloom syndrome protein 0.0073 0.0206 0.0206
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.008 0.0592
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0113 0.0239
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0114 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0469
Schistosoma mansoni sphingosine kinase A B 0.1213 0.4714 0.4714
Mycobacterium tuberculosis Diacylglycerol kinase 0.0047 0.0103 0.0219
Brugia malayi PHD-finger family protein 0.0064 0.0168 0.1235
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0201 0.0427
Schistosoma mansoni transcription factor btf3 0.0038 0.0066 0.0066
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0049 0.011 0.011
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0216 0.0458
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0113 0.0113
Loa Loa (eye worm) RNA binding protein 0.0065 0.0173 0.0367
Trichomonas vaginalis hypothetical protein 0.0022 0.0002 0.0017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0241 0.1778
Entamoeba histolytica hypothetical protein 0.0025 0.0016 0.0034
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0079 0.0228 0.0483
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0098 0.0724
Schistosoma mansoni myst-related protein 0.0025 0.0016 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0201 0.0427
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0228 0.1678
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0066 0.0139
Brugia malayi hypothetical protein 0.0047 0.0103 0.076
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0047 0.0103 0.0103
Schistosoma mansoni phosphoglycerate kinase 0.0365 0.1358 0.1358
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0077 0.0565
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0091 0.0276 0.1115
Mycobacterium leprae Probable lipase LipE 0.0077 0.0221 0.1629
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0221 0.0894
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0064 0.0137
Loa Loa (eye worm) hypothetical protein 0.006 0.0152 0.0323
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0197 0.0197
Treponema pallidum exodeoxyribonuclease (exoA) 0.0079 0.0228 0.1557
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0129 0.0274
Onchocerca volvulus 0.0047 0.0103 0.1005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0077 0.0565
Trichomonas vaginalis DNA helicase recq1, putative 0.0073 0.0206 0.1518
Schistosoma mansoni hypothetical protein 0.0047 0.0103 0.0103
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0103 0.0219
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0221 0.1629
Echinococcus granulosus microtubule associated protein 2 0.0694 0.2662 0.2662
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.008 0.008
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.0103 0.0103
Echinococcus granulosus Diacylglycerol kinase theta 0.0047 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0002 0.0017
Schistosoma mansoni cpg binding protein 0.0193 0.0681 0.0681
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0197 0.0418
Mycobacterium ulcerans DNA polymerase IV 0.0171 0.0591 0.1254
Mycobacterium tuberculosis Conserved protein 0.0077 0.0221 0.0469
Loa Loa (eye worm) hypothetical protein 0.0072 0.0201 0.0427
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0046 0.0097 0.0097
Echinococcus granulosus expressed protein 0.0049 0.011 0.011
Echinococcus granulosus phosphoglycerate kinase 1 0.0365 0.1358 0.1358
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0066 0.0483
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0365 0.1358 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0068 0.0501
Loa Loa (eye worm) hypothetical protein 0.0072 0.0201 0.0427
Mycobacterium ulcerans hypothetical protein 0.0341 0.1264 0.2681
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0141 0.0475 0.1008
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0103 0.076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0128 0.0422 0.0895
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0221 0.0221
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0221 0.0469
Trypanosoma brucei DNA damage repair protein, putative 0.0035 0.0056 0.0225
Mycobacterium ulcerans lipase LipD 0.0077 0.0221 0.0469
Brugia malayi Pre-SET motif family protein 0.0039 0.007 0.0513
Toxoplasma gondii TIM10 family protein, putative 0.0049 0.011 0.0807
Schistosoma mansoni blooms syndrome DNA helicase 0.0058 0.0145 0.0145
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0216 0.0703
Trypanosoma cruzi DNA polymerase eta, putative 0.0168 0.0582 0.235
Schistosoma mansoni hypothetical protein 0.255 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0075 0.0214 0.0214
Brugia malayi Bromodomain containing protein 0.0082 0.0241 0.1772
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0221 0.0469
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0039 0.007 0.007
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0047 0.0103 0.0103
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0365 0.1358 0.5488
Leishmania major mitochondrial DNA polymerase beta 0.0647 0.2474 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.007 0.007
Loa Loa (eye worm) ceramide kinase 0.0047 0.0103 0.0219
Echinococcus granulosus tar DNA binding protein 0.0065 0.0173 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0098 0.0098
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0049 0.0049
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0228 0.1678
Loa Loa (eye worm) hypothetical protein 0.0075 0.0214 0.0454
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0077 0.0565
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0047 0.0103 0.0219
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0469
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0201 0.1484
Schistosoma mansoni hypothetical protein 0.0097 0.03 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0282 0.114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0381 0.1423 0.1423
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0061 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0056 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0066 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0351 0.0351
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0066 0.014
Echinococcus granulosus sphingosine kinase 1 0.1213 0.4714 0.4714
Toxoplasma gondii diacylglycerol kinase, putative 0.0047 0.0103 0.076
Leishmania major hypothetical protein, conserved 0.0077 0.0221 0.0894
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0306 0.1127 0.4554
Trichomonas vaginalis DNA helicase recq, putative 0.0039 0.0071 0.0524
Trypanosoma brucei unspecified product 0.0157 0.0535 0.2163
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0064 0.0171 0.1258
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0047 0.0103 0.0417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0098 0.0098
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0036 0.0036
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0049 0.011 0.0233
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0077 0.0565
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0365 0.1358 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0141 0.0475 0.1921
Trypanosoma brucei DNA polymerase eta, putative 0.0168 0.0582 0.235
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0221 0.1629
Brugia malayi Ceramide kinase 0.0047 0.0103 0.076
Schistosoma mansoni hypothetical protein 0.0164 0.0564 0.0564
Mycobacterium ulcerans hypothetical protein 0.1213 0.4714 1
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0221 0.0894
Leishmania major hypothetical protein, conserved 0.0047 0.0103 0.0417
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0036 0.0036
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0049 0.0112 0.0822
Trichomonas vaginalis diacylglycerol kinase, putative 0.0047 0.0103 0.076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0241 0.0241
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0134 0.0445 0.18
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0118 0.025
Schistosoma mansoni DNA helicase recq1 0.003 0.0036 0.0036
Plasmodium falciparum diacylglycerol kinase, putative 0.0047 0.0103 0.076
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0216 0.1589
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0036 0.0264
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0241 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0068 0.0501
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0134 0.0445 0.18
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0221 0.0469
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0201 0.0427
Onchocerca volvulus Ceramide kinase 1 homolog 0.0047 0.0103 0.1005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0221 0.0221
Schistosoma mansoni zinc finger protein 0.0033 0.0046 0.0046
Leishmania major hypothetical protein, conserved 0.0033 0.0046 0.0185
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0216 0.0216
Toxoplasma gondii exonuclease III APE 0.0079 0.0228 0.1678
Loa Loa (eye worm) beta-lactamase 0.0077 0.0221 0.0469
Trichomonas vaginalis diacylglycerol kinase, putative 0.0047 0.0103 0.076
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0023 0.0023
Trypanosoma brucei Sphingosine kinase 0.0047 0.0103 0.0417
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0201 0.0814
Schistosoma mansoni ap endonuclease 0.0079 0.0228 0.0228
Brugia malayi F/Y-rich N-terminus family protein 0.006 0.0154 0.1132
Trypanosoma cruzi diacylglycerol kinase, putative 0.0047 0.0103 0.0417
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0247 0.0894 0.1896
Trichomonas vaginalis sphingosine kinase, putative 0.0047 0.0103 0.076
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0076
Entamoeba histolytica deoxycytidyl transferase, putative 0.0114 0.0366 0.0776
Brugia malayi hypothetical protein 0.0037 0.0065 0.0475
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0201 0.0814
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0064 0.0475
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0306 0.1127 0.4554
Schistosoma mansoni alkaline phosphatase 0.0187 0.0655 0.0655
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0365 0.1358 0.5488
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0276 0.1115
Plasmodium falciparum phosphoglycerate kinase 0.0365 0.1358 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0075 0.0214 0.0214
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0079 0.0228 0.0921
Plasmodium vivax diacylglycerol kinase, putative 0.0047 0.0103 0.076
Loa Loa (eye worm) hypothetical protein 0.0054 0.0129 0.0274
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0047 0.0103 0.0417
Schistosoma mansoni phosphoglycerate kinase 0.0365 0.1358 0.1358
Trypanosoma brucei chrX additional, unordered contigs 0.0035 0.0056 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Echinococcus multilocularis expressed protein 0.0038 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0054 0.0129 0.0274
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0098 0.0208
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.008 0.0592
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0103 0.0219
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0241 0.0512
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0129 0.0953
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0019 0.0143
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.0619 0.4557
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0173
Leishmania major DNA polymerase eta, putative 0.009 0.0272 0.1097
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0047 0.0103 0.076
Schistosoma mansoni hypothetical protein 0.011 0.0351 0.0351
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0173 0.0173
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0079 0.0228 0.0228
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0066 0.0265
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0197 0.0418
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0071 0.0287
Onchocerca volvulus 0.006 0.0152 0.1485
Trypanosoma cruzi Sphingosine kinase 0.0047 0.0103 0.0417
Trypanosoma cruzi DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0221 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Echinococcus granulosus fetal alzheimer antigen falz 0.0058 0.0148 0.0148
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.3143 0.3143
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0365 0.1358 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0077 0.0565
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0046 0.0097 0.0097
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0091 0.0276 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0565
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0216 0.0216
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0197 0.0418
Trichomonas vaginalis rotamase, putative 0.0038 0.0068 0.0501
Trypanosoma brucei unspecified product 0.0078 0.0226 0.0914
Echinococcus granulosus ceramide kinase 0.0047 0.0103 0.0103
Giardia lamblia DNA damage repair protein 0.0035 0.0056 0.015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0201 0.1484
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0281 0.1136
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0091 0.0193
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0071 0.0287
Echinococcus granulosus zinc finger protein 0.0052 0.0122 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0469
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0173
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0036 0.0264
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0068 0.0144
Mycobacterium tuberculosis Conserved hypothetical protein 0.0341 0.1264 0.2681
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0187 0.0655 0.0655
Mycobacterium tuberculosis Conserved protein 0.0077 0.0221 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0565
Brugia malayi Bromodomain containing protein 0.0171 0.0592 0.4359
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0241 0.0241
Giardia lamblia Phosphoglycerate kinase 0.0365 0.1358 1
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0129 0.0953
Leishmania major DNA polymerase kappa, putative 0.0128 0.0422 0.1704
Schistosoma mansoni hypothetical protein 0.0178 0.0619 0.0619
Echinococcus multilocularis dna polymerase kappa 0.0171 0.0591 0.0591
Brugia malayi Probable ClpP-like protease 0.0076 0.0216 0.1589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0098 0.0098
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0241 0.0241
Mycobacterium tuberculosis Conserved protein 0.0077 0.0221 0.0469
Echinococcus multilocularis ceramide kinase 0.0047 0.0103 0.0103
Brugia malayi beta-lactamase family protein 0.0077 0.0221 0.1629
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Echinococcus granulosus geminin 0.0164 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0365 0.1358 0.288
Leishmania major phosphoglycerate kinase C, glycosomal 0.0365 0.1358 0.5488
Brugia malayi Bloom's syndrome protein homolog 0.0073 0.0206 0.1518
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.011 0.0807
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0036 0.0036
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0047 0.0103 0.0103
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0036 0.0264
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0197 0.145
Entamoeba histolytica recQ family helicase, putative 0.0039 0.0071 0.0151
Schistosoma mansoni cpg binding protein 0.0179 0.0624 0.0624
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0173 0.0367
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0141 0.0475 0.3501
Loa Loa (eye worm) glutaminase 2 0.0314 0.1158 0.2457
Mycobacterium tuberculosis Conserved protein 0.1213 0.4714 1
Giardia lamblia DINP protein human, muc B family 0.0128 0.0422 0.2918
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0276 0.1115
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0049 0.011 0.0807
Schistosoma mansoni rotamase 0.0038 0.0068 0.0068
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0047 0.0103 0.0417
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0103 0.0417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0098 0.0098
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0103 0.0219
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0019 0.0143
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0141 0.0475 0.0475
Mycobacterium ulcerans diacylglycerol kinase 0.0047 0.0103 0.0219
Brugia malayi RNA binding protein 0.0065 0.0173 0.1273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0118 0.025
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.011 0.0807
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0064 0.026
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0365 0.1358 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0039 0.007 0.007
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0216 0.1589
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.1009 0.1009
Schistosoma mansoni survival motor neuron protein 0.0056 0.0139 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0201 0.1484
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Plasmodium falciparum zinc finger protein, putative 0.0025 0.0016 0.0118
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0216 0.0216
Echinococcus multilocularis transcription factor Dp 1 0.0082 0.024 0.024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0049 0.011 0.0809
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0201 0.0814
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0221 0.0469
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0216 0.1589
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0103 0.0219
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0216 0.1589
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0075 0.0214 0.0214
Leishmania major sphingosine kinase A, B, putative 0.0047 0.0103 0.0417
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0351 0.0351
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0201 0.0427
Trypanosoma brucei unspecified product 0.0078 0.0226 0.0914
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0351 0.0351
Schistosoma mansoni DNA helicase recq5 0.003 0.0036 0.0036
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0134 0.0445 0.18
Trichomonas vaginalis set domain proteins, putative 0.0281 0.1027 0.756
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.008 0.0592
Trichomonas vaginalis rotamase, putative 0.0037 0.0064 0.0475
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0118 0.025
Toxoplasma gondii hypothetical protein 0.0026 0.0019 0.0143
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0221 0.0469
Brugia malayi Phosphoglycerate kinase 0.0134 0.0445 0.3281
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0221 0.1629
Echinococcus multilocularis dnaJ subfamily B 0.255 1 1
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0047 0.0103 0.076
Brugia malayi hypothetical protein 0.0276 0.1009 0.7432
Brugia malayi polk-prov protein 0.0092 0.0281 0.207
Plasmodium vivax DNA repair protein REV1, putative 0.0035 0.0056 0.0411
Toxoplasma gondii ImpB/MucB/SamB family protein 0.009 0.0272 0.2
Echinococcus granulosus intestinal type alkaline phosphatase 0.0187 0.0655 0.0655
Echinococcus granulosus GPCR family 2 0.0082 0.0241 0.0241
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0064 0.026
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0221 0.0221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Schistosoma mansoni zinc finger protein 0.0052 0.0122 0.0122
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0171 0.0591 0.4353
Trichomonas vaginalis bmru protein, putative 0.0047 0.0103 0.076
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0241 0.1778
Brugia malayi diacylglycerol kinase 0.0047 0.0103 0.076
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.0103 0.0103
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0134 0.0445 0.18
Onchocerca volvulus 0.0077 0.0221 0.2155
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0066 0.0483
Trypanosoma brucei ISWI complex protein 0.0033 0.0046 0.0185
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0201 0.0427
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.005 0.0112 0.0826
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0173 0.0367
Loa Loa (eye worm) hypothetical protein 0.0082 0.0241 0.0512
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0647 0.2474 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0079 0.0228 0.0483
Brugia malayi Eye-specific diacylglycerol kinase 0.0047 0.0103 0.076
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0187 0.0655 0.0655
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0197 0.0418
Trypanosoma cruzi diacylglycerol kinase, putative 0.0047 0.0103 0.0417
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0064 0.026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0201 0.0427
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0064 0.026
Entamoeba histolytica hypothetical protein, conserved 0.1213 0.4714 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0042 0.008 0.008
Echinococcus granulosus dna polymerase eta 0.0168 0.0582 0.0582
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0197 0.0796
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0422 0.1704
Leishmania major DNA polymerase eta, putative 0.0168 0.0582 0.235
Entamoeba histolytica hypothetical protein 0.011 0.0351 0.0744
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0216 0.0703
Brugia malayi TAR-binding protein 0.0065 0.0173 0.1273
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0047 0.0103 0.0103
Brugia malayi hypothetical protein 0.011 0.0351 0.2584
Loa Loa (eye worm) diacylglycerol kinase 2 0.0047 0.0103 0.0219
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0079 0.0228 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0056 0.0225
Brugia malayi beta-NAC-like protein 0.0038 0.0066 0.0483
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0493 0.1865 0.3956
Loa Loa (eye worm) histone methyltransferase 0.0057 0.014 0.0298
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0114 0.0366 0.0366
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0046 0.0097 0.0097
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0201 0.1484
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0066 0.0265
Brugia malayi CXXC zinc finger family protein 0.0179 0.0624 0.4598
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0201 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0565
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.2662 0.2662
Entamoeba histolytica hypothetical protein 0.011 0.0351 0.0744
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0141 0.0475 0.0475
Leishmania major phosphoglycerate kinase B, cytosolic 0.0365 0.1358 0.5488
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0061 0.0061
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.0171
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.1009 0.1009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0098 0.0098
Schistosoma mansoni glutaminase 0.0314 0.1158 0.1158
Echinococcus multilocularis dna polymerase eta 0.0168 0.0582 0.0582
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0138 0.0462 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0565
Trichomonas vaginalis glutaminase, putative 0.0314 0.1158 0.853
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0036 0.0076
Loa Loa (eye worm) hypothetical protein 0.0047 0.0103 0.0219
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0221 0.0894
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0173 0.1273
Brugia malayi glutaminase DH11.1 0.0314 0.1158 0.853
Plasmodium falciparum DNA repair protein REV1, putative 0.0035 0.0056 0.0411
Onchocerca volvulus 0.0039 0.007 0.0679
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0079 0.0228 0.0921
Trypanosoma brucei DNA polymerase IV, putative 0.0157 0.0535 0.2163
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0113 0.0113
Trichomonas vaginalis sphingosine kinase, putative 0.0047 0.0103 0.076
Schistosoma mansoni myst-related protein 0.0025 0.0016 0.0016
Echinococcus multilocularis geminin 0.0164 0.0564 0.0564
Trypanosoma cruzi DNA polymerase eta, putative 0.009 0.0272 0.1097
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0066 0.0483
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0469
Trypanosoma brucei phosphoglycerate kinase 0.0134 0.0445 0.18
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0565
Echinococcus granulosus tumor protein p63 0.0408 0.153 0.153
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0173
Schistosoma mansoni alkaline phosphatase 0.0187 0.0655 0.0655
Onchocerca volvulus 0.0179 0.0624 0.6081
Echinococcus multilocularis GPCR, family 2 0.0082 0.0241 0.0241
Leishmania major basic transcription factor 3a, putative 0.0038 0.0066 0.0265
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0221 0.1629
Schistosoma mansoni ap endonuclease 0.0079 0.0228 0.0228
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0141 0.0475 0.0475
Echinococcus multilocularis cpg binding protein 0.0193 0.0681 0.0681
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0066 0.0483
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0114 0.0366 0.0366
Mycobacterium tuberculosis Conserved hypothetical protein 0.0114 0.0366 0.0776
Schistosoma mansoni hypothetical protein 0.0164 0.0564 0.0564
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0141 0.0475 0.1921
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0087 0.0261 0.0554
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0187 0.0655 0.0655
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0221 0.0469
Mycobacterium ulcerans phosphoglycerate kinase 0.0365 0.1358 0.288
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0036 0.0264
Loa Loa (eye worm) hypothetical protein 0.0047 0.0103 0.0219
Brugia malayi beta-lactamase 0.0077 0.0221 0.1629
Brugia malayi Phosphoglycerate kinase 0.0365 0.1358 1
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0221 0.0469
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0221 0.0221
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0047 0.0103 0.0103
Mycobacterium ulcerans glutaminase 0.0314 0.1158 0.2457
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0056 0.0225
Mycobacterium ulcerans beta-lactamase 0.0077 0.0221 0.0469
Trypanosoma brucei DNA damage repair protein, putative 0.0035 0.0056 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0173 0.0173
Schistosoma mansoni sphingoid long chain base kinase 0.1213 0.4714 0.4714
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0139 0.1025
Plasmodium vivax diacylglycerol kinase, putative 0.0047 0.0103 0.076
Brugia malayi Diacylglycerol kinase protein 2 0.0047 0.0103 0.076
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0565
Trypanosoma brucei phosphoglycerate kinase 0.0365 0.1358 0.5488
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0111 0.0355 0.1433
Brugia malayi beta-lactamase family protein 0.0077 0.0221 0.1629
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.008 0.0592
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0306 0.1127 0.4554
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0039 0.007 0.0513
Schistosoma mansoni terminal deoxycytidyl transferase 0.0114 0.0366 0.0366
Echinococcus multilocularis Diacylglycerol kinase theta 0.0047 0.0103 0.0103
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0047 0.0103 0.076
Echinococcus granulosus transcription factor btf3 0.0038 0.0066 0.0066
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0066 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.0591 0.2389
Trypanosoma cruzi Sphingosine kinase 0.0047 0.0103 0.0417
Echinococcus multilocularis zinc finger protein 0.0052 0.0122 0.0122
Trypanosoma cruzi DNA damage repair protein, putative 0.0035 0.0056 0.0225
Schistosoma mansoni hypothetical protein 0.0033 0.0046 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0201 0.0427
Loa Loa (eye worm) hypothetical protein 0.0175 0.0609 0.1293
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0152 0.0152
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0113 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0075 0.0214 0.0214
Echinococcus multilocularis transcription factor btf3 0.0038 0.0066 0.0066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0002 0.0017
Brugia malayi hypothetical protein 0.0037 0.0065 0.0475
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0221 0.0469
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0201 0.0427
Echinococcus granulosus mixed lineage leukemia protein mll 0.0046 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0102 0.0318 0.0674
Loa Loa (eye worm) RecQ helicase 0.0073 0.0206 0.0437
Brugia malayi diacylglycerol kinase 0.0047 0.0103 0.076
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0365 0.1358 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0281 0.1136
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0056 0.0411
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0187 0.0655 0.0655
Leishmania major DNA polymerase kappa, putative 0.0035 0.0056 0.0225
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0221 0.1629
Brugia malayi ImpB/MucB/SamB family protein 0.0168 0.0582 0.4283
Brugia malayi exodeoxyribonuclease III family protein 0.0079 0.0228 0.1678
Schistosoma mansoni DNA polymerase eta 0.0168 0.0582 0.0582
Loa Loa (eye worm) CXXC zinc finger family protein 0.0179 0.0624 0.1324
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0141 0.0475 0.1921
Loa Loa (eye worm) hypothetical protein 0.0072 0.0201 0.0427
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0047 0.0103 0.0219
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0079 0.0228 0.0921
Echinococcus multilocularis phosphoglycerate kinase 1 0.0365 0.1358 0.1358
Plasmodium vivax phosphoglycerate kinase, putative 0.0365 0.1358 1
Schistosoma mansoni hypothetical protein 0.0082 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0178 0.0619 0.1313
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0071 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0066 0.0483
Loa Loa (eye worm) hypothetical protein 0.026 0.0944 0.2002
Trichomonas vaginalis DNA helicase recq, putative 0.0073 0.0206 0.1518
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0221 0.0221
Brugia malayi Pre-SET motif family protein 0.0247 0.0894 0.6581
Loa Loa (eye worm) hypothetical protein 0.0092 0.0281 0.0596
Trichomonas vaginalis helicase, putative 0.0041 0.0077 0.0565
Trypanosoma brucei DNA polymerase IV, putative 0.0171 0.0591 0.2389
Schistosoma mansoni DNA polymerase IV / kappa 0.0035 0.0056 0.0056
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0047 0.0103 0.076
Echinococcus multilocularis sphingosine kinase 1 0.1213 0.4714 0.4714
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0221 0.1629
Plasmodium falciparum diacylglycerol kinase, putative 0.0047 0.0103 0.076
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0469
Schistosoma mansoni hypothetical protein 0.0082 0.0241 0.0241
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0201 0.0427
Schistosoma mansoni hypothetical protein 0.0082 0.0241 0.0241
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0079 0.0228 0.0921
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0113 0.0829
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0118 0.025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.0944 0.2002
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0565
Leishmania major DNA damage repair protein, putative 0.0035 0.0056 0.0225
Loa Loa (eye worm) hypothetical protein 0.0082 0.0241 0.0512
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0221 0.1629
Chlamydia trachomatis phosphoglycerate kinase 0.0365 0.1358 1
Plasmodium vivax SET domain protein, putative 0.0039 0.007 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0282 0.114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0129 0.0274
Echinococcus granulosus Diacylglycerol kinase zeta 0.0047 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0044 0.0091 0.0091
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0134 0.0445 0.18
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0138 0.0462 0.0462
Trypanosoma brucei phosphoglycerate kinase 0.0365 0.1358 0.5488
Brugia malayi ImpB/MucB/SamB family protein 0.0114 0.0366 0.2694
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0047 0.0103 0.076
Trypanosoma cruzi ISWI complex protein 0.0033 0.0046 0.0185

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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